ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.13490967
2	DNA double-strand break processing (GO:0000729)	3.93180906
3	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.78818283
4	ribosomal small subunit assembly (GO:0000028)	3.77749401
5	base-excision repair, AP site formation (GO:0006285)	3.69987830
6	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.67524042
7	cullin deneddylation (GO:0010388)	3.59355164
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.57883634
9	ATP synthesis coupled proton transport (GO:0015986)	3.57883634
10	protein deneddylation (GO:0000338)	3.57218166
11	proteasome assembly (GO:0043248)	3.44296154
12	protein neddylation (GO:0045116)	3.42469339
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.42029161
14	protein complex biogenesis (GO:0070271)	3.36924267
15	L-fucose catabolic process (GO:0042355)	3.35314799
16	fucose catabolic process (GO:0019317)	3.35314799
17	L-fucose metabolic process (GO:0042354)	3.35314799
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.34670447
19	chaperone-mediated protein transport (GO:0072321)	3.31306182
20	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.30108599
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.30036853
22	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.30036853
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.29913635
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.29913635
25	NADH dehydrogenase complex assembly (GO:0010257)	3.29913635
26	pseudouridine synthesis (GO:0001522)	3.25413696
27	protein-cofactor linkage (GO:0018065)	3.18075456
28	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.16346050
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.15554562
30	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.13420417
31	preassembly of GPI anchor in ER membrane (GO:0016254)	3.12646507
32	platelet dense granule organization (GO:0060155)	3.11457857
33	rRNA modification (GO:0000154)	3.08600140
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.08156922
35	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.07297341
36	iron-sulfur cluster assembly (GO:0016226)	3.05944040
37	metallo-sulfur cluster assembly (GO:0031163)	3.05944040
38	behavioral response to nicotine (GO:0035095)	3.04287221
39	GTP biosynthetic process (GO:0006183)	3.02938943
40	response to pheromone (GO:0019236)	3.01002793
41	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.98814363
42	DNA catabolic process, exonucleolytic (GO:0000738)	2.94521105
43	isotype switching (GO:0045190)	2.92793035
44	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.92793035
45	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.92793035
46	mannosylation (GO:0097502)	2.90121662
47	GPI anchor metabolic process (GO:0006505)	2.89168255
48	replication fork processing (GO:0031297)	2.88148159
49	DNA damage response, detection of DNA damage (GO:0042769)	2.85553972
50	chromatin remodeling at centromere (GO:0031055)	2.85491127
51	ribosomal large subunit biogenesis (GO:0042273)	2.83917226
52	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.81678947
53	termination of RNA polymerase III transcription (GO:0006386)	2.81678947
54	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.77280609
55	regulation of mitotic spindle checkpoint (GO:1903504)	2.77280609
56	respiratory chain complex IV assembly (GO:0008535)	2.76718262
57	kynurenine metabolic process (GO:0070189)	2.75874301
58	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.74115675
59	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.74115675
60	CENP-A containing nucleosome assembly (GO:0034080)	2.73001972
61	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.70028414
62	tRNA processing (GO:0008033)	2.69893174
63	L-methionine salvage (GO:0071267)	2.68943614
64	L-methionine biosynthetic process (GO:0071265)	2.68943614
65	amino acid salvage (GO:0043102)	2.68943614
66	maturation of 5.8S rRNA (GO:0000460)	2.68556765
67	GPI anchor biosynthetic process (GO:0006506)	2.68308173
68	DNA demethylation (GO:0080111)	2.66888690
69	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.66234203
70	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.65769737
71	peptidyl-histidine modification (GO:0018202)	2.64189612
72	indolalkylamine metabolic process (GO:0006586)	2.61350819
73	deoxyribonucleotide catabolic process (GO:0009264)	2.59541368
74	tryptophan catabolic process (GO:0006569)	2.59402182
75	indole-containing compound catabolic process (GO:0042436)	2.59402182
76	indolalkylamine catabolic process (GO:0046218)	2.59402182
77	rRNA methylation (GO:0031167)	2.59304675
78	cytochrome complex assembly (GO:0017004)	2.58952120
79	recombinational repair (GO:0000725)	2.58134273
80	ubiquinone biosynthetic process (GO:0006744)	2.56745282
81	regulation of cellular amino acid metabolic process (GO:0006521)	2.56095699
82	pyrimidine nucleotide catabolic process (GO:0006244)	2.55868692
83	negative regulation of telomere maintenance (GO:0032205)	2.55424519
84	ubiquinone metabolic process (GO:0006743)	2.52908847
85	double-strand break repair via homologous recombination (GO:0000724)	2.52042428
86	cytidine metabolic process (GO:0046087)	2.50850617
87	cytidine catabolic process (GO:0006216)	2.50850617
88	cytidine deamination (GO:0009972)	2.50850617
89	deoxyribose phosphate catabolic process (GO:0046386)	2.50518929
90	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.49927794
91	UTP metabolic process (GO:0046051)	2.49658018
92	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.49546271
93	branched-chain amino acid catabolic process (GO:0009083)	2.49077483
94	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.48684752
95	mismatch repair (GO:0006298)	2.48381682
96	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.48165725
97	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.48165725
98	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.48165725
99	UTP biosynthetic process (GO:0006228)	2.45804033
100	histone exchange (GO:0043486)	2.45568375

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.04052001
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.90025517
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.47923385
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.40348934
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.12131497
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.93220900
7	VDR_22108803_ChIP-Seq_LS180_Human	2.85706977
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.80588183
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.79793540
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.76956934
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.63251597
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.60838233
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.59270601
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.58451045
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.43674130
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.29497877
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.29029052
18	EWS_26573619_Chip-Seq_HEK293_Human	2.28996528
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.20276157
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.18106379
21	MYC_18940864_ChIP-ChIP_HL60_Human	2.09047746
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05527711
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.00910989
24	FUS_26573619_Chip-Seq_HEK293_Human	1.93205941
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.91242329
26	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.81489150
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.80737636
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.80470134
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.78808407
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.71267339
31	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68795173
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.67198272
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66629214
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.60808705
35	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.58977320
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57886194
37	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.53327394
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.52453968
39	P300_19829295_ChIP-Seq_ESCs_Human	1.51238956
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50702015
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.50529956
42	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50428866
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.44700263
44	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.39684701
45	GBX2_23144817_ChIP-Seq_PC3_Human	1.32391643
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32001751
47	GABP_19822575_ChIP-Seq_HepG2_Human	1.30704051
48	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.30648299
49	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29859477
50	TTF2_22483619_ChIP-Seq_HELA_Human	1.28231965
51	ER_23166858_ChIP-Seq_MCF-7_Human	1.28090030
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27105138
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27105138
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25587270
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25587270
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23861477
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23367363
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.23367363
59	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.22921182
60	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22459706
61	DCP1A_22483619_ChIP-Seq_HELA_Human	1.20476323
62	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.18641394
63	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.17821529
64	AR_20517297_ChIP-Seq_VCAP_Human	1.16137065
65	E2F7_22180533_ChIP-Seq_HELA_Human	1.14326377
66	NCOR_22424771_ChIP-Seq_293T_Human	1.13456582
67	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.12068414
68	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.09366110
69	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.07747143
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05569172
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04285200
72	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.03762835
73	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03135477
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02990597
75	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.02059140
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01068500
77	GATA3_26560356_Chip-Seq_TH2_Human	0.99601948
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.98070596
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97870912
80	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.97445391
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96508819
82	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.95990539
83	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.95168741
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.94961162
85	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.94856236
86	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.94298003
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93350520
88	RNF2_27304074_Chip-Seq_NSC_Mouse	0.92516048
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.90422830
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.90172782
91	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.88998387
92	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.88851998
93	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.88279973
94	BCAT_22108803_ChIP-Seq_LS180_Human	0.88238663
95	TCF4_22108803_ChIP-Seq_LS180_Human	0.87704913
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.87549094
97	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87425785
98	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87355579
99	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.85273290
100	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.84898545

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.40950809
2	MP0002102_abnormal_ear_morphology	3.17007218
3	MP0008877_abnormal_DNA_methylation	3.03860481
4	MP0008058_abnormal_DNA_repair	2.93746144
5	MP0006072_abnormal_retinal_apoptosis	2.52100722
6	MP0005671_abnormal_response_to	2.37020218
7	MP0004147_increased_porphyrin_level	2.16710650
8	MP0002736_abnormal_nociception_after	2.04971467
9	MP0008875_abnormal_xenobiotic_pharmacok	1.93912864
10	MP0000372_irregular_coat_pigmentation	1.91114317
11	MP0005551_abnormal_eye_electrophysiolog	1.88658259
12	MP0003787_abnormal_imprinting	1.87512874
13	MP0008995_early_reproductive_senescence	1.87049952
14	MP0003786_premature_aging	1.86202459
15	MP0008872_abnormal_physiological_respon	1.85262256
16	MP0005084_abnormal_gallbladder_morpholo	1.84010280
17	MP0010094_abnormal_chromosome_stability	1.83814819
18	MP0005645_abnormal_hypothalamus_physiol	1.83163273
19	MP0001529_abnormal_vocalization	1.75667711
20	MP0001968_abnormal_touch/_nociception	1.74839716
21	MP0005646_abnormal_pituitary_gland	1.71887934
22	MP0003195_calcinosis	1.71076230
23	MP0003011_delayed_dark_adaptation	1.68249503
24	MP0005253_abnormal_eye_physiology	1.67555072
25	MP0003693_abnormal_embryo_hatching	1.67188796
26	MP0008789_abnormal_olfactory_epithelium	1.62199468
27	MP0003880_abnormal_central_pattern	1.53196146
28	MP0003646_muscle_fatigue	1.49159047
29	MP0001764_abnormal_homeostasis	1.44624426
30	MP0002876_abnormal_thyroid_physiology	1.44201213
31	MP0002163_abnormal_gland_morphology	1.41325103
32	MP0002234_abnormal_pharynx_morphology	1.40022635
33	MP0005389_reproductive_system_phenotype	1.39714632
34	MP0004885_abnormal_endolymph	1.39238346
35	MP0002160_abnormal_reproductive_system	1.36958097
36	MP0005075_abnormal_melanosome_morpholog	1.36243529
37	MP0006276_abnormal_autonomic_nervous	1.35781804
38	MP0003718_maternal_effect	1.35075486
39	MP0003121_genomic_imprinting	1.33679683
40	MP0002837_dystrophic_cardiac_calcinosis	1.33047076
41	MP0003567_abnormal_fetal_cardiomyocyte	1.32282311
42	MP0001293_anophthalmia	1.22164384
43	MP0001835_abnormal_antigen_presentation	1.21485889
44	MP0000631_abnormal_neuroendocrine_gland	1.21354491
45	MP0009379_abnormal_foot_pigmentation	1.21112427
46	MP0001919_abnormal_reproductive_system	1.18040008
47	MP0001873_stomach_inflammation	1.17767578
48	MP0000049_abnormal_middle_ear	1.17379419
49	MP0005499_abnormal_olfactory_system	1.15238523
50	MP0005394_taste/olfaction_phenotype	1.15238523
51	MP0001986_abnormal_taste_sensitivity	1.14843945
52	MP0006036_abnormal_mitochondrial_physio	1.14517508
53	MP0009785_altered_susceptibility_to	1.09544679
54	MP0004133_heterotaxia	1.08187674
55	MP0002938_white_spotting	1.07129530
56	MP0001188_hyperpigmentation	1.06674474
57	MP0002751_abnormal_autonomic_nervous	1.05879198
58	MP0005379_endocrine/exocrine_gland_phen	1.05562532
59	MP0004145_abnormal_muscle_electrophysio	1.05518435
60	MP0002095_abnormal_skin_pigmentation	1.05396153
61	MP0004142_abnormal_muscle_tone	1.04348485
62	MP0006035_abnormal_mitochondrial_morpho	1.04095698
63	MP0001929_abnormal_gametogenesis	1.02171801
64	MP0002210_abnormal_sex_determination	0.99541899
65	MP0004957_abnormal_blastocyst_morpholog	0.98097724
66	MP0001984_abnormal_olfaction	0.94509426
67	MP0003186_abnormal_redox_activity	0.92876278
68	MP0003806_abnormal_nucleotide_metabolis	0.92546330
69	MP0001905_abnormal_dopamine_level	0.91750721
70	MP0009697_abnormal_copulation	0.91042207
71	MP0002638_abnormal_pupillary_reflex	0.90639473
72	MP0001119_abnormal_female_reproductive	0.90467440
73	MP0009333_abnormal_splenocyte_physiolog	0.89967348
74	MP0002272_abnormal_nervous_system	0.89549168
75	MP0002148_abnormal_hypersensitivity_rea	0.89386680
76	MP0000653_abnormal_sex_gland	0.88528903
77	MP0001145_abnormal_male_reproductive	0.86848709
78	MP0002138_abnormal_hepatobiliary_system	0.85761598
79	MP0003119_abnormal_digestive_system	0.84448479
80	MP0001800_abnormal_humoral_immune	0.83016113
81	MP0003698_abnormal_male_reproductive	0.82361522
82	MP0008007_abnormal_cellular_replicative	0.80098205
83	MP0003878_abnormal_ear_physiology	0.79256665
84	MP0005377_hearing/vestibular/ear_phenot	0.79256665
85	MP0001501_abnormal_sleep_pattern	0.79232683
86	MP0003763_abnormal_thymus_physiology	0.78097124
87	MP0008932_abnormal_embryonic_tissue	0.77817686
88	MP0003937_abnormal_limbs/digits/tail_de	0.76201165
89	MP0005085_abnormal_gallbladder_physiolo	0.75396950
90	MP0005410_abnormal_fertilization	0.75329280
91	MP0000689_abnormal_spleen_morphology	0.75034884
92	MP0001485_abnormal_pinna_reflex	0.75007935
93	MP0003111_abnormal_nucleus_morphology	0.74032687
94	MP0002653_abnormal_ependyma_morphology	0.74020930
95	MP0001486_abnormal_startle_reflex	0.73091058
96	MP0005195_abnormal_posterior_eye	0.72636902
97	MP0005636_abnormal_mineral_homeostasis	0.71911622
98	MP0009745_abnormal_behavioral_response	0.71654037
99	MP0002277_abnormal_respiratory_mucosa	0.71590746
100	MP0002822_catalepsy	0.71007575

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.45223211
2	Acute necrotizing encephalopathy (HP:0006965)	3.38711613
3	True hermaphroditism (HP:0010459)	3.16490976
4	Mitochondrial inheritance (HP:0001427)	3.13822704
5	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.12383961
6	Acute encephalopathy (HP:0006846)	3.04612324
7	Molar tooth sign on MRI (HP:0002419)	3.04320435
8	Abnormality of midbrain morphology (HP:0002418)	3.04320435
9	Pancreatic fibrosis (HP:0100732)	3.02534481
10	Increased CSF lactate (HP:0002490)	3.00437729
11	Congenital stationary night blindness (HP:0007642)	2.98220941
12	Increased hepatocellular lipid droplets (HP:0006565)	2.95275247
13	Abnormal mitochondria in muscle tissue (HP:0008316)	2.95179379
14	Abolished electroretinogram (ERG) (HP:0000550)	2.87221959
15	Methylmalonic acidemia (HP:0002912)	2.85394868
16	Progressive macrocephaly (HP:0004481)	2.84483886
17	Lipid accumulation in hepatocytes (HP:0006561)	2.77883820
18	Colon cancer (HP:0003003)	2.75005548
19	Attenuation of retinal blood vessels (HP:0007843)	2.73517202
20	Nephronophthisis (HP:0000090)	2.73427821
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.70717967
22	3-Methylglutaconic aciduria (HP:0003535)	2.69156966
23	IgG deficiency (HP:0004315)	2.67738436
24	Pendular nystagmus (HP:0012043)	2.54678544
25	Hyperglycinemia (HP:0002154)	2.52447008
26	Hepatocellular necrosis (HP:0001404)	2.51900702
27	Renal Fanconi syndrome (HP:0001994)	2.48238326
28	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.47221070
29	Severe combined immunodeficiency (HP:0004430)	2.43817585
30	Medial flaring of the eyebrow (HP:0010747)	2.41606396
31	Optic disc pallor (HP:0000543)	2.40226285
32	Constricted visual fields (HP:0001133)	2.35156502
33	Increased serum lactate (HP:0002151)	2.34346696
34	Hepatic necrosis (HP:0002605)	2.33560740
35	Abnormality of the renal cortex (HP:0011035)	2.32980117
36	Cerebral edema (HP:0002181)	2.32430385
37	Abnormality of B cell number (HP:0010975)	2.29860684
38	Abnormality of alanine metabolism (HP:0010916)	2.28592830
39	Hyperalaninemia (HP:0003348)	2.28592830
40	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.28592830
41	Renal cortical cysts (HP:0000803)	2.27182442
42	Methylmalonic aciduria (HP:0012120)	2.23315219
43	Abnormality of the labia minora (HP:0012880)	2.21975380
44	Type II lissencephaly (HP:0007260)	2.18586082
45	Abnormality of the renal medulla (HP:0100957)	2.17869128
46	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.14692232
47	Decreased central vision (HP:0007663)	2.13726172
48	Type 2 muscle fiber atrophy (HP:0003554)	2.12953940
49	Lactic acidosis (HP:0003128)	2.11635791
50	B lymphocytopenia (HP:0010976)	2.10690458
51	Abnormality of macular pigmentation (HP:0008002)	2.08117102
52	Sclerocornea (HP:0000647)	2.07971820
53	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.07025139
54	Thyroiditis (HP:0100646)	2.05051835
55	Abnormal biliary tract physiology (HP:0012439)	2.04363458
56	Bile duct proliferation (HP:0001408)	2.04363458
57	Abnormality of the ileum (HP:0001549)	2.03969019
58	Increased intramyocellular lipid droplets (HP:0012240)	2.02843528
59	Abnormal protein glycosylation (HP:0012346)	2.00663079
60	Abnormal glycosylation (HP:0012345)	2.00663079
61	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.00663079
62	Abnormal protein N-linked glycosylation (HP:0012347)	2.00663079
63	Hypoproteinemia (HP:0003075)	1.99537413
64	Meckel diverticulum (HP:0002245)	1.99390927
65	Aplasia/hypoplasia of the uterus (HP:0008684)	1.98886653
66	Type I transferrin isoform profile (HP:0003642)	1.96895307
67	Exertional dyspnea (HP:0002875)	1.96342039
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96117377
69	Asplenia (HP:0001746)	1.95149817
70	Volvulus (HP:0002580)	1.94794141
71	Lethargy (HP:0001254)	1.93175279
72	Abnormality of glycine metabolism (HP:0010895)	1.93108633
73	Abnormality of serine family amino acid metabolism (HP:0010894)	1.93108633
74	Abnormality of serum amino acid levels (HP:0003112)	1.92911523
75	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.90902324
76	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.90902324
77	Combined immunodeficiency (HP:0005387)	1.87380375
78	Hypoplasia of the uterus (HP:0000013)	1.86113829
79	Thyroid-stimulating hormone excess (HP:0002925)	1.86043203
80	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.85739059
81	Cystic liver disease (HP:0006706)	1.83605799
82	Absent thumb (HP:0009777)	1.82987530
83	Lissencephaly (HP:0001339)	1.82851317
84	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.82850361
85	Absent/shortened dynein arms (HP:0200106)	1.82850361
86	Postaxial foot polydactyly (HP:0001830)	1.81702711
87	Chronic hepatic failure (HP:0100626)	1.79069050
88	Carpal bone hypoplasia (HP:0001498)	1.79024672
89	Abnormal drinking behavior (HP:0030082)	1.78298037
90	Polydipsia (HP:0001959)	1.78298037
91	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.77191592
92	Congenital primary aphakia (HP:0007707)	1.75284327
93	Increased corneal curvature (HP:0100692)	1.75051398
94	Keratoconus (HP:0000563)	1.75051398
95	Hyperglycinuria (HP:0003108)	1.74504382
96	Abnormality of the prostate (HP:0008775)	1.73603648
97	Pancytopenia (HP:0001876)	1.73485548
98	Gait imbalance (HP:0002141)	1.72671504
99	Anencephaly (HP:0002323)	1.72031447
100	Abnormal number of erythroid precursors (HP:0012131)	1.71761900

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.69968668
2	ZAK	3.17041625
3	BCKDK	2.92056515
4	NUAK1	2.75100116
5	TXK	2.73845006
6	ADRBK2	2.46919729
7	WNK3	2.24650276
8	VRK2	2.20403658
9	TRIM28	2.10960788
10	CDK19	2.08753224
11	EIF2AK3	1.97406058
12	GRK1	1.96875706
13	FRK	1.89755476
14	TAOK3	1.85251304
15	PINK1	1.84503794
16	TLK1	1.80315039
17	SRPK1	1.74920229
18	MKNK1	1.74812138
19	WNK4	1.69435446
20	MST4	1.59415906
21	MAP3K4	1.57441278
22	VRK1	1.54968743
23	STK16	1.53580188
24	BUB1	1.52239001
25	KIT	1.44856816
26	PLK4	1.42574452
27	PLK3	1.35771909
28	ERBB3	1.32959012
29	MAPK13	1.28381707
30	DYRK2	1.26469957
31	KDR	1.26180014
32	NEK1	1.25559994
33	BCR	1.23994926
34	MAP2K7	1.22141805
35	BMPR1B	1.18404469
36	TSSK6	1.18369080
37	TEC	1.16803993
38	FLT3	1.12756377
39	OXSR1	1.11207119
40	CDC7	1.08095427
41	INSRR	1.05398398
42	CSNK1G3	1.04920428
43	PASK	1.04914292
44	TIE1	1.00476157
45	MAP4K1	0.99953207
46	RPS6KA4	0.99388472
47	TAF1	0.98184755
48	MKNK2	0.94823040
49	CSNK1G1	0.94822039
50	CSNK1G2	0.93396630
51	EIF2AK2	0.85884052
52	ITK	0.82512334
53	PBK	0.81923843
54	STK39	0.81289904
55	TESK2	0.80545697
56	ATR	0.80445990
57	CSNK1A1L	0.78481678
58	BRSK2	0.78417305
59	PLK1	0.78372691
60	ACVR1B	0.76087456
61	IKBKB	0.73923860
62	CDK3	0.68279082
63	MUSK	0.64514596
64	PRKCQ	0.63935548
65	NME1	0.63579666
66	SYK	0.62883980
67	GRK6	0.61667321
68	WEE1	0.61341875
69	RPS6KA5	0.59129778
70	TNIK	0.58899653
71	PLK2	0.57099465
72	CHEK2	0.56105659
73	ADRBK1	0.55749230
74	DAPK1	0.53518223
75	NEK2	0.52379979
76	EIF2AK1	0.52316299
77	CSNK2A1	0.52011633
78	PRKCE	0.51926096
79	CSF1R	0.50529990
80	IKBKE	0.49020567
81	TTK	0.48386167
82	ATM	0.46593140
83	AURKB	0.46277197
84	MAPKAPK5	0.45561855
85	CAMKK2	0.43784313
86	MATK	0.43569833
87	DYRK3	0.42645990
88	PRKCG	0.42268776
89	NME2	0.41066200
90	CSNK2A2	0.40110778
91	IGF1R	0.39543643
92	LYN	0.38604507
93	TGFBR1	0.38038734
94	EPHA4	0.37943107
95	OBSCN	0.37610833
96	CSNK1A1	0.37158180
97	FES	0.36652366
98	LCK	0.36560854
99	CCNB1	0.36240868
100	PHKG2	0.36074126

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.39897758
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.65646710
3	Ribosome_Homo sapiens_hsa03010	2.60608576
4	RNA polymerase_Homo sapiens_hsa03020	2.48016898
5	Protein export_Homo sapiens_hsa03060	2.43492936
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.41375276
7	Homologous recombination_Homo sapiens_hsa03440	2.24896370
8	Parkinsons disease_Homo sapiens_hsa05012	2.23747164
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.10937188
10	Mismatch repair_Homo sapiens_hsa03430	2.08005829
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.03009835
12	Basal transcription factors_Homo sapiens_hsa03022	1.93752838
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.91042105
14	RNA degradation_Homo sapiens_hsa03018	1.87796234
15	DNA replication_Homo sapiens_hsa03030	1.87585511
16	Asthma_Homo sapiens_hsa05310	1.84152537
17	Base excision repair_Homo sapiens_hsa03410	1.82878532
18	Phototransduction_Homo sapiens_hsa04744	1.82248419
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.81089154
20	Primary immunodeficiency_Homo sapiens_hsa05340	1.80635242
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.78508723
22	Propanoate metabolism_Homo sapiens_hsa00640	1.60163530
23	One carbon pool by folate_Homo sapiens_hsa00670	1.57905521
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.55983912
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.55366927
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.50633349
27	Caffeine metabolism_Homo sapiens_hsa00232	1.49035688
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.47459192
29	Allograft rejection_Homo sapiens_hsa05330	1.45774237
30	Spliceosome_Homo sapiens_hsa03040	1.45210116
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43570271
32	RNA transport_Homo sapiens_hsa03013	1.40175375
33	Huntingtons disease_Homo sapiens_hsa05016	1.39158651
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.37079166
35	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.31718224
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.30965817
37	Graft-versus-host disease_Homo sapiens_hsa05332	1.29539962
38	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.26556687
39	Butanoate metabolism_Homo sapiens_hsa00650	1.24922901
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.24708925
41	Purine metabolism_Homo sapiens_hsa00230	1.22839098
42	Alzheimers disease_Homo sapiens_hsa05010	1.22193256
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.21544594
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.16787586
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.14772319
46	Tryptophan metabolism_Homo sapiens_hsa00380	1.13711082
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.13461234
48	Peroxisome_Homo sapiens_hsa04146	1.13275425
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.11294167
50	Sulfur metabolism_Homo sapiens_hsa00920	1.09611992
51	Nitrogen metabolism_Homo sapiens_hsa00910	1.07847210
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.05365508
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03266407
54	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.03108096
55	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00941350
56	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.95000114
57	Olfactory transduction_Homo sapiens_hsa04740	0.91282410
58	Antigen processing and presentation_Homo sapiens_hsa04612	0.87705557
59	Steroid biosynthesis_Homo sapiens_hsa00100	0.82550987
60	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.82388069
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.81126663
62	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.80155804
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.79896224
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74798553
65	Fatty acid elongation_Homo sapiens_hsa00062	0.74314449
66	Metabolic pathways_Homo sapiens_hsa01100	0.73106698
67	Sulfur relay system_Homo sapiens_hsa04122	0.72796310
68	Retinol metabolism_Homo sapiens_hsa00830	0.72723192
69	Rheumatoid arthritis_Homo sapiens_hsa05323	0.72472096
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.68169130
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67313717
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65509571
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65158247
74	Cardiac muscle contraction_Homo sapiens_hsa04260	0.64449153
75	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.64169426
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62600328
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.61980636
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61819441
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.60864935
80	Regulation of autophagy_Homo sapiens_hsa04140	0.58354613
81	Nicotine addiction_Homo sapiens_hsa05033	0.57848789
82	Pyruvate metabolism_Homo sapiens_hsa00620	0.57594200
83	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.56382243
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56133736
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53176191
86	Taste transduction_Homo sapiens_hsa04742	0.50669238
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45371504
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44069362
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42331355
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38855819
91	Collecting duct acid secretion_Homo sapiens_hsa04966	0.37086706
92	Glutathione metabolism_Homo sapiens_hsa00480	0.36864244
93	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.34600958
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.32051220
95	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30727223
96	Fatty acid degradation_Homo sapiens_hsa00071	0.26420433
97	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.25991819
98	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.25849548
99	Cell cycle_Homo sapiens_hsa04110	0.25336494
100	p53 signaling pathway_Homo sapiens_hsa04115	0.25134598

HNRNPA1P48

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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