HNRNPA1P49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.74391911
2modulation by symbiont of host immune response (GO:0052553)5.18829037
3positive regulation by symbiont of host defense response (GO:0052509)5.18829037
4modulation by symbiont of host defense response (GO:0052031)5.18829037
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.18829037
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.18829037
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.18829037
8response to peptidoglycan (GO:0032494)5.00733394
9cellular extravasation (GO:0045123)4.86614937
10regulation of B cell receptor signaling pathway (GO:0050855)4.85073065
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.54362227
12detection of molecule of bacterial origin (GO:0032490)4.45721747
13response to muramyl dipeptide (GO:0032495)4.40330472
14B cell receptor signaling pathway (GO:0050853)4.30386121
15regulation of gamma-delta T cell activation (GO:0046643)4.13052634
16germinal center formation (GO:0002467)4.09067811
17neutrophil activation involved in immune response (GO:0002283)4.06282959
18regulation of interferon-beta biosynthetic process (GO:0045357)4.05209822
19macrophage activation involved in immune response (GO:0002281)3.99721997
20response to host immune response (GO:0052572)3.94537699
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.94537699
22negative regulation of erythrocyte differentiation (GO:0045647)3.90692792
23negative regulation of interleukin-12 production (GO:0032695)3.84943020
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.83532914
25negative regulation of cell killing (GO:0031342)3.83532914
26response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.79864347
27response to host (GO:0075136)3.79864347
28response to host defenses (GO:0052200)3.79864347
29detection of other organism (GO:0098543)3.77871236
30response to interleukin-15 (GO:0070672)3.62761800
31detection of external biotic stimulus (GO:0098581)3.58523758
32positive regulation of B cell differentiation (GO:0045579)3.56345498
33positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.51166978
34regulation of gamma-delta T cell differentiation (GO:0045586)3.48708181
35neutrophil activation (GO:0042119)3.46837093
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40249698
37detection of bacterium (GO:0016045)3.32028476
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30197478
39negative thymic T cell selection (GO:0045060)3.23287110
40B cell homeostasis (GO:0001782)3.22469067
41regulation of B cell differentiation (GO:0045577)3.21467673
42granulocyte activation (GO:0036230)3.19836298
43antigen processing and presentation of endogenous antigen (GO:0019883)3.19544114
44detection of biotic stimulus (GO:0009595)3.19294281
45nuclear pore complex assembly (GO:0051292)3.18787989
46macrophage activation (GO:0042116)3.18551869
47negative regulation of toll-like receptor signaling pathway (GO:0034122)3.18310634
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16451517
49negative regulation of T cell mediated immunity (GO:0002710)3.16226854
50myeloid cell activation involved in immune response (GO:0002275)3.15579237
51lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08598086
52histone H3-K4 trimethylation (GO:0080182)3.07099830
53cellular response to interleukin-15 (GO:0071350)3.05334813
54regulation of mast cell degranulation (GO:0043304)3.04195326
55neutrophil mediated immunity (GO:0002446)3.03481601
56negative T cell selection (GO:0043383)3.03358402
57positive regulation of interferon-alpha production (GO:0032727)3.03039253
58T-helper 1 type immune response (GO:0042088)3.02776014
59immunoglobulin mediated immune response (GO:0016064)3.02305128
60embryonic process involved in female pregnancy (GO:0060136)3.00890090
61negative regulation of lymphocyte mediated immunity (GO:0002707)2.99859243
62positive regulation of granulocyte differentiation (GO:0030854)2.97513471
63antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94590576
64regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93068816
65microglial cell activation (GO:0001774)2.90518978
66regulation of histone H3-K27 methylation (GO:0061085)2.90261699
67leukocyte aggregation (GO:0070486)2.87808096
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.87341055
69T cell migration (GO:0072678)2.87182405
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86136052
71positive thymic T cell selection (GO:0045059)2.84556051
72response to protozoan (GO:0001562)2.81412065
73regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.81194968
74regulation of mast cell activation involved in immune response (GO:0033006)2.81173115
75defense response to protozoan (GO:0042832)2.79002860
76regulation of interferon-alpha production (GO:0032647)2.76573251
77tolerance induction (GO:0002507)2.75883894
78cellular response to ethanol (GO:0071361)2.74471412
79regulation of interleukin-12 biosynthetic process (GO:0045075)2.74393063
80NIK/NF-kappaB signaling (GO:0038061)2.72984334
81negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.72842211
82leukocyte degranulation (GO:0043299)2.72706128
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.71445094
84production of molecular mediator involved in inflammatory response (GO:0002532)2.70307223
85regulation of toll-like receptor signaling pathway (GO:0034121)2.69627103
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68656541
87negative regulation of T-helper cell differentiation (GO:0045623)2.68656541
88regulation of mast cell activation (GO:0033003)2.68470560
89regulation of leukocyte degranulation (GO:0043300)2.67457487
90JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.67321606
91histone H3-K36 demethylation (GO:0070544)2.66498848
92positive regulation of toll-like receptor signaling pathway (GO:0034123)2.65653006
93leukocyte migration involved in inflammatory response (GO:0002523)2.65579684
94megakaryocyte development (GO:0035855)2.64542858
95regulation of myeloid leukocyte mediated immunity (GO:0002886)2.64315413
96regulation of dendritic cell antigen processing and presentation (GO:0002604)2.62438759
97B cell mediated immunity (GO:0019724)2.61324814
98mannose metabolic process (GO:0006013)2.61324704
99positive regulation of cellular amide metabolic process (GO:0034250)2.60490563
100respiratory burst (GO:0045730)2.60186570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.60339544
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.32130178
3MYC_22102868_ChIP-Seq_BL_Human3.93272034
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.73761822
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.67389638
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.55122786
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20846899
8MYB_21317192_ChIP-Seq_ERMYB_Mouse3.09041209
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.02852027
10VDR_21846776_ChIP-Seq_THP-1_Human2.94973774
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88447944
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.86477705
13E2F7_22180533_ChIP-Seq_HELA_Human2.74324179
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63160943
15VDR_24763502_ChIP-Seq_THP-1_Human2.59890392
16RUNX_20019798_ChIP-Seq_JUKART_Human2.59865143
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.58618105
18SPI1_23547873_ChIP-Seq_NB4_Human2.57628211
19MYB_26560356_Chip-Seq_TH2_Human2.57273082
20MAF_26560356_Chip-Seq_TH1_Human2.54028010
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.47580569
22MYB_26560356_Chip-Seq_TH1_Human2.37207159
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31938082
24SPI1_23127762_ChIP-Seq_K562_Human2.31453039
25TCF7_22412390_ChIP-Seq_EML_Mouse2.28567228
26SCL_19346495_ChIP-Seq_HPC-7_Human2.27988453
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27612296
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.26860053
29BP1_19119308_ChIP-ChIP_Hs578T_Human2.24842538
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20705727
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.18456640
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.16813908
33STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12395393
34UTX_26944678_Chip-Seq_JUKART_Human2.11934767
35GATA1_22025678_ChIP-Seq_K562_Human2.01204553
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99718904
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.98607871
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.94516555
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91291717
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.88365527
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84001879
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.77693265
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76095186
44TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.74994623
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74235394
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71650076
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69301016
48MAF_26560356_Chip-Seq_TH2_Human1.68229577
49KDM2B_26808549_Chip-Seq_DND41_Human1.63007542
50CIITA_25753668_ChIP-Seq_RAJI_Human1.61114917
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58367388
52GATA3_27048872_Chip-Seq_THYMUS_Human1.55432998
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.54281762
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.53174987
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49353959
56VDR_24787735_ChIP-Seq_THP-1_Human1.48956700
57PU_27001747_Chip-Seq_BMDM_Mouse1.47843318
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47764290
59GATA1_19941826_ChIP-Seq_K562_Human1.46949718
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.45039149
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42209747
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.40344071
63NCOR1_26117541_ChIP-Seq_K562_Human1.30772635
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.28314786
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28304958
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28136005
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27304905
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.23242510
69GATA2_19941826_ChIP-Seq_K562_Human1.21373347
70TFEB_21752829_ChIP-Seq_HELA_Human1.19084344
71GATA3_26560356_Chip-Seq_TH2_Human1.16136279
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11525078
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10417653
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10332585
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07292123
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03527899
77RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01499210
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00200140
79ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96310421
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95723260
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94456086
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94338423
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93608957
84HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92942379
85ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91993733
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91196354
87E2F4_17652178_ChIP-ChIP_JURKAT_Human0.89167808
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88794478
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88659809
90STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88656849
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88012960
92GATA2_21666600_ChIP-Seq_HMVEC_Human0.86817972
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86362998
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85523392
95PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84768267
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83707661
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82801446
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81644430
99PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81063871
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.77201044

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.97094105
2MP0003436_decreased_susceptibility_to3.65739298
3MP0001835_abnormal_antigen_presentation3.46693708
4MP0003724_increased_susceptibility_to3.21969007
5MP0002396_abnormal_hematopoietic_system3.17456404
6MP0001800_abnormal_humoral_immune2.84478014
7MP0000685_abnormal_immune_system2.82529152
8MP0002419_abnormal_innate_immunity2.66858478
9MP0005000_abnormal_immune_tolerance2.56447549
10MP0005387_immune_system_phenotype2.47932299
11MP0001790_abnormal_immune_system2.47932299
12MP0005451_abnormal_body_composition2.43986992
13MP0002452_abnormal_antigen_presenting2.40769441
14MP0002723_abnormal_immune_serum2.36963470
15MP0002420_abnormal_adaptive_immunity2.32723523
16MP0001819_abnormal_immune_cell2.29241961
17MP0005025_abnormal_response_to2.26578365
18MP0005671_abnormal_response_to2.24709715
19MP0003763_abnormal_thymus_physiology2.22305175
20MP0002398_abnormal_bone_marrow2.15271027
21MP0008260_abnormal_autophagy2.11944214
22MP0003300_gastrointestinal_ulcer2.09807713
23MP0008057_abnormal_DNA_replication2.08132899
24MP0005464_abnormal_platelet_physiology2.04404971
25MP0003172_abnormal_lysosome_physiology1.96862098
26MP0002166_altered_tumor_susceptibility1.91595602
27MP0000716_abnormal_immune_system1.90425805
28MP0009278_abnormal_bone_marrow1.87688205
29MP0003656_abnormal_erythrocyte_physiolo1.86537371
30MP0004947_skin_inflammation1.84564937
31MP0004808_abnormal_hematopoietic_stem1.82302734
32MP0002405_respiratory_system_inflammati1.81400820
33MP0002722_abnormal_immune_system1.80535496
34MP0000689_abnormal_spleen_morphology1.77984347
35MP0005076_abnormal_cell_differentiation1.77719186
36MP0009785_altered_susceptibility_to1.75278558
37MP0005397_hematopoietic_system_phenotyp1.67757055
38MP0001545_abnormal_hematopoietic_system1.67757055
39MP0000703_abnormal_thymus_morphology1.66226039
40MP0002429_abnormal_blood_cell1.63096504
41MP0002148_abnormal_hypersensitivity_rea1.62725950
42MP0003828_pulmonary_edema1.54770675
43MP0002006_tumorigenesis1.53606613
44MP0002009_preneoplasia1.53075295
45MP0005310_abnormal_salivary_gland1.50500660
46MP0010155_abnormal_intestine_physiology1.50094415
47MP0010352_gastrointestinal_tract_polyps1.49301203
48MP0001853_heart_inflammation1.49033564
49MP0001533_abnormal_skeleton_physiology1.47066094
50MP0002132_abnormal_respiratory_system1.45112232
51MP0001845_abnormal_inflammatory_respons1.41593063
52MP0004381_abnormal_hair_follicle1.37657850
53MP0003221_abnormal_cardiomyocyte_apopto1.28078795
54MP0006082_CNS_inflammation1.22009222
55MP0009764_decreased_sensitivity_to1.21836656
56MP0009333_abnormal_splenocyte_physiolog1.20757319
57MP0000858_altered_metastatic_potential1.18414899
58MP0003091_abnormal_cell_migration1.16598847
59MP0003191_abnormal_cellular_cholesterol1.13866080
60MP0002998_abnormal_bone_remodeling1.12653679
61MP0008469_abnormal_protein_level1.08535419
62MP0001851_eye_inflammation1.08454672
63MP0003183_abnormal_peptide_metabolism1.08005374
64MP0003045_fibrosis1.05415243
65MP0002138_abnormal_hepatobiliary_system1.03264820
66MP0000465_gastrointestinal_hemorrhage1.01015843
67MP0001873_stomach_inflammation1.00457267
68MP0010094_abnormal_chromosome_stability0.97119416
69MP0003075_altered_response_to0.95290221
70MP0003866_abnormal_defecation0.94057951
71MP0004883_abnormal_blood_vessel0.93074100
72MP0008004_abnormal_stomach_pH0.91566175
73MP0010307_abnormal_tumor_latency0.90315577
74MP0009763_increased_sensitivity_to0.89855136
75MP0004510_myositis0.88548303
76MP0002019_abnormal_tumor_incidence0.88220036
77MP0005164_abnormal_response_to0.87358755
78MP0003111_abnormal_nucleus_morphology0.86112360
79MP0000569_abnormal_digit_pigmentation0.84711417
80MP0000609_abnormal_liver_physiology0.82404809
81MP0001915_intracranial_hemorrhage0.82170482
82MP0005058_abnormal_lysosome_morphology0.82013891
83MP0005621_abnormal_cell_physiology0.81499048
84MP0009765_abnormal_xenobiotic_induced0.79772890
85MP0000313_abnormal_cell_death0.78053453
86MP0008007_abnormal_cellular_replicative0.77510842
87MP0003566_abnormal_cell_adhesion0.77168554
88MP0002877_abnormal_melanocyte_morpholog0.77145115
89MP0008961_abnormal_basal_metabolism0.72774787
90MP0003077_abnormal_cell_cycle0.71955509
91MP0000015_abnormal_ear_pigmentation0.71893839
92MP0009115_abnormal_fat_cell0.70818844
93MP0003448_altered_tumor_morphology0.69236225
94MP0000350_abnormal_cell_proliferation0.62308291
95MP0002332_abnormal_exercise_endurance0.62110969
96MP0005409_darkened_coat_color0.61701031
97MP0003705_abnormal_hypodermis_morpholog0.61322082
98MP0002933_joint_inflammation0.60668261
99MP0000249_abnormal_blood_vessel0.60324393
100MP0000598_abnormal_liver_morphology0.60042165

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.47791691
2Recurrent abscess formation (HP:0002722)4.35125681
3Abnormal delayed hypersensitivity skin test (HP:0002963)4.29094779
4Eczematoid dermatitis (HP:0000976)4.21987961
5Optic neuritis (HP:0100653)4.11121762
6Retrobulbar optic neuritis (HP:0100654)4.11121762
7Orchitis (HP:0100796)4.01030915
8Myositis (HP:0100614)3.92680075
9Recurrent viral infections (HP:0004429)3.82166903
10Recurrent cutaneous fungal infections (HP:0011370)3.77083490
11Chronic mucocutaneous candidiasis (HP:0002728)3.77083490
12Recurrent fungal infections (HP:0002841)3.77005315
13Panhypogammaglobulinemia (HP:0003139)3.72162265
14Colitis (HP:0002583)3.60810256
15Meningitis (HP:0001287)3.60742202
16Abnormality of macrophages (HP:0004311)3.48282525
17Viral hepatitis (HP:0006562)3.44401574
18Recurrent skin infections (HP:0001581)3.35116737
19Encephalitis (HP:0002383)3.24563174
20Mediastinal lymphadenopathy (HP:0100721)3.22458854
21Gastrointestinal infarctions (HP:0005244)3.19923052
22Recurrent gram-negative bacterial infections (HP:0005420)3.16241888
23Vasculitis (HP:0002633)3.15856173
24Abnormality of the fingertips (HP:0001211)3.15150617
25Agammaglobulinemia (HP:0004432)3.13580996
26Keratoconjunctivitis sicca (HP:0001097)3.12712909
27Inflammation of the large intestine (HP:0002037)3.10244435
28Spontaneous hematomas (HP:0007420)3.00891418
29Cellulitis (HP:0100658)2.99042521
30Gastrointestinal inflammation (HP:0004386)2.96953887
31Obstructive lung disease (HP:0006536)2.88484660
32Chronic obstructive pulmonary disease (HP:0006510)2.88484660
33Gastrointestinal stroma tumor (HP:0100723)2.86443607
34Prolonged bleeding time (HP:0003010)2.81712700
35Keratoconjunctivitis (HP:0001096)2.74662816
36Arterial thrombosis (HP:0004420)2.73647903
37T lymphocytopenia (HP:0005403)2.71466691
38Increased IgE level (HP:0003212)2.65993123
39Abnormality of T cell physiology (HP:0011840)2.62698745
40Abnormality of T cell number (HP:0011839)2.62669731
41Abnormality of the peritoneum (HP:0002585)2.59651017
42Autoimmune hemolytic anemia (HP:0001890)2.58501033
43Abnormality of T cells (HP:0002843)2.54818722
44Elevated erythrocyte sedimentation rate (HP:0003565)2.52695401
45Epistaxis (HP:0000421)2.52300553
46Subacute progressive viral hepatitis (HP:0006572)2.41565344
47Gingival bleeding (HP:0000225)2.41030338
48Stomatitis (HP:0010280)2.40635556
49Granulocytopenia (HP:0001913)2.38752703
50Gingivitis (HP:0000230)2.38084608
51Urticaria (HP:0001025)2.37294687
52Fatigue (HP:0012378)2.32457440
53Osteomyelitis (HP:0002754)2.31759680
54Slow saccadic eye movements (HP:0000514)2.31336652
55Chest pain (HP:0100749)2.28518867
56Lymphopenia (HP:0001888)2.26530448
57Autoimmune thrombocytopenia (HP:0001973)2.26129576
58IgM deficiency (HP:0002850)2.25990767
59Pulmonary infiltrates (HP:0002113)2.23677817
60Episodic fever (HP:0001954)2.21863692
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.21074325
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.17976279
63Hemoptysis (HP:0002105)2.15240042
64Acute lymphatic leukemia (HP:0006721)2.14906149
65Peritonitis (HP:0002586)2.14608982
66Syringomyelia (HP:0003396)2.14007768
67Spinal cord lesions (HP:0100561)2.14007768
68Pulmonary embolism (HP:0002204)2.10238886
69Pustule (HP:0200039)2.08026988
70Verrucae (HP:0200043)2.03043888
71Papilloma (HP:0012740)2.03043888
72Abnormal platelet volume (HP:0011876)2.00066421
73IgA deficiency (HP:0002720)1.98573477
74Leukocytosis (HP:0001974)1.98002838
75Deep philtrum (HP:0002002)1.97947216
76Abnormality of the common coagulation pathway (HP:0010990)1.97851301
77Gangrene (HP:0100758)1.96503496
78Hepatitis (HP:0012115)1.96269887
79Dislocated radial head (HP:0003083)1.93543294
80Lymphoma (HP:0002665)1.93183543
81Anorexia (HP:0002039)1.93113406
82Abnormality of B cell number (HP:0010975)1.92376942
83Aplasia/Hypoplasia of the thymus (HP:0010515)1.89966672
84Eosinophilia (HP:0001880)1.88708020
85Abnormality of the pleura (HP:0002103)1.88630215
86Menorrhagia (HP:0000132)1.88451347
87Acute myeloid leukemia (HP:0004808)1.86507923
88B lymphocytopenia (HP:0010976)1.84834171
89Deep venous thrombosis (HP:0002625)1.84776424
90Segmental peripheral demyelination/remyelination (HP:0003481)1.84229360
91Recurrent sinusitis (HP:0011108)1.83964672
92Somatic mutation (HP:0001428)1.83076325
93Glomerulopathy (HP:0100820)1.81742177
94Sepsis (HP:0100806)1.80822514
95Abnormality of the endocardium (HP:0004306)1.77695439
96Dysmetric saccades (HP:0000641)1.76384683
97Recurrent bronchitis (HP:0002837)1.75192377
98Thrombophlebitis (HP:0004418)1.73906070
99Papilledema (HP:0001085)1.73905447
100Basal cell carcinoma (HP:0002671)1.73585931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.55852836
2PRPF4B3.27373118
3CDK122.99770640
4MAP4K12.95604333
5MAP3K142.91254593
6IRAK42.69299192
7BLK2.47950605
8MAP2K32.38962262
9TYK22.08984469
10BMPR21.99536114
11SIK21.88897284
12ERN11.87635886
13BTK1.76679992
14IRAK31.72144762
15MAP3K131.70251447
16CSK1.69899507
17JAK11.65822930
18BRD41.64985104
19TRIB31.62168017
20ZAP701.62144348
21JAK31.58165915
22SYK1.56541332
23TAOK31.44788072
24IKBKE1.42134745
25IRAK11.41157221
26FGFR31.40631003
27HCK1.40505939
28KSR21.40120504
29SIK31.36820599
30IRAK21.33807760
31FGFR41.29305115
32MAP3K101.28033154
33TEC1.25175119
34GRK61.22234673
35SMG11.20807271
36FES1.19766586
37FGR1.18507475
38TBK11.14528449
39IKBKB1.14375512
40JAK21.13238826
41WNK11.10915689
42MATK1.09303192
43YES11.07455785
44NEK91.06864584
45ITK1.03884329
46KIT1.02946829
47LYN0.99080130
48ICK0.98640451
49CDC42BPA0.97158280
50TNK20.96638938
51TXK0.94567286
52MAP3K10.93178738
53CDK40.92377220
54AKT30.91209012
55EPHB10.91173305
56MARK30.87435449
57LCK0.86344022
58MAP3K70.86064977
59SIK10.85591073
60CDK60.84459991
61MARK20.83326898
62STK100.82977662
63MAP3K20.82275592
64PIK3CG0.81312091
65MAPK110.79913431
66CHUK0.76514516
67EEF2K0.75516345
68CLK10.75137812
69TAOK10.74779437
70TAOK20.73642508
71MAP3K30.73164714
72PIM10.70224684
73CSF1R0.67659182
74MELK0.65374390
75MAP3K60.64409172
76CAMK1D0.64175651
77RAF10.61697784
78SGK30.61513412
79MAPK120.60037416
80TRPM70.59624299
81RET0.57606085
82PDK10.56812190
83MAP3K50.56211483
84PKN20.55252723
85MTOR0.53106972
86MKNK10.52681845
87SGK20.50152296
88NLK0.48805789
89ALK0.48784954
90MAPK70.48058336
91MAP3K80.47906175
92PDPK10.47846716
93PRKCQ0.47328696
94PTK60.44617439
95KSR10.42483216
96PDGFRB0.39606080
97CAMK1G0.39016353
98PRKD20.37671277
99PRKAA20.35427039
100RPS6KB20.33934827

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.85201560
2Leishmaniasis_Homo sapiens_hsa051402.58869222
3Osteoclast differentiation_Homo sapiens_hsa043802.41403495
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.19742556
5Acute myeloid leukemia_Homo sapiens_hsa052212.12506634
6Staphylococcus aureus infection_Homo sapiens_hsa051501.99879268
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98275394
8Non-small cell lung cancer_Homo sapiens_hsa052231.95295257
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85334420
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.83804448
11Chronic myeloid leukemia_Homo sapiens_hsa052201.82449787
12Measles_Homo sapiens_hsa051621.81313897
13Primary immunodeficiency_Homo sapiens_hsa053401.76869695
14Tuberculosis_Homo sapiens_hsa051521.75104089
15Influenza A_Homo sapiens_hsa051641.71903164
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71183007
17Hepatitis B_Homo sapiens_hsa051611.69706541
18Pancreatic cancer_Homo sapiens_hsa052121.69061222
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60882004
20T cell receptor signaling pathway_Homo sapiens_hsa046601.60349952
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55597275
22Toxoplasmosis_Homo sapiens_hsa051451.52334983
23Graft-versus-host disease_Homo sapiens_hsa053321.51361273
24Herpes simplex infection_Homo sapiens_hsa051681.49356797
25TNF signaling pathway_Homo sapiens_hsa046681.49196404
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.48283089
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46406398
28Allograft rejection_Homo sapiens_hsa053301.42220090
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.38155831
30Hematopoietic cell lineage_Homo sapiens_hsa046401.35674921
31Other glycan degradation_Homo sapiens_hsa005111.32543663
32Autoimmune thyroid disease_Homo sapiens_hsa053201.27364294
33Apoptosis_Homo sapiens_hsa042101.25659567
34Hepatitis C_Homo sapiens_hsa051601.25263717
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.18588553
36Legionellosis_Homo sapiens_hsa051341.18134316
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17491500
38Chemokine signaling pathway_Homo sapiens_hsa040621.17270922
39Viral carcinogenesis_Homo sapiens_hsa052031.16308834
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15945461
41Malaria_Homo sapiens_hsa051441.15610106
42Renal cell carcinoma_Homo sapiens_hsa052111.14019971
43Prolactin signaling pathway_Homo sapiens_hsa049171.12487684
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09315244
45VEGF signaling pathway_Homo sapiens_hsa043701.06800889
46Platelet activation_Homo sapiens_hsa046111.05308185
47Epstein-Barr virus infection_Homo sapiens_hsa051691.01176711
48Endometrial cancer_Homo sapiens_hsa052130.99126866
49Antigen processing and presentation_Homo sapiens_hsa046120.97893415
50Dorso-ventral axis formation_Homo sapiens_hsa043200.97441777
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97219066
52Prostate cancer_Homo sapiens_hsa052150.96688806
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96506164
54Viral myocarditis_Homo sapiens_hsa054160.96314617
55mTOR signaling pathway_Homo sapiens_hsa041500.95248187
56Colorectal cancer_Homo sapiens_hsa052100.95148861
57FoxO signaling pathway_Homo sapiens_hsa040680.94733433
58Asthma_Homo sapiens_hsa053100.94281532
59Type I diabetes mellitus_Homo sapiens_hsa049400.92988110
60Choline metabolism in cancer_Homo sapiens_hsa052310.91232233
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91145322
62Notch signaling pathway_Homo sapiens_hsa043300.89054301
63Small cell lung cancer_Homo sapiens_hsa052220.89008226
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.85771044
65Inositol phosphate metabolism_Homo sapiens_hsa005620.84097556
66Bladder cancer_Homo sapiens_hsa052190.83432060
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81877359
68Insulin resistance_Homo sapiens_hsa049310.78146962
69Type II diabetes mellitus_Homo sapiens_hsa049300.77914692
70Glioma_Homo sapiens_hsa052140.77818013
71Shigellosis_Homo sapiens_hsa051310.76533129
72HIF-1 signaling pathway_Homo sapiens_hsa040660.76371429
73HTLV-I infection_Homo sapiens_hsa051660.75706769
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.75604023
75ErbB signaling pathway_Homo sapiens_hsa040120.75030395
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.73479644
77MicroRNAs in cancer_Homo sapiens_hsa052060.72758064
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71678053
79Pertussis_Homo sapiens_hsa051330.70645658
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.70203736
81GnRH signaling pathway_Homo sapiens_hsa049120.69306500
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68802860
83African trypanosomiasis_Homo sapiens_hsa051430.65163013
84Amoebiasis_Homo sapiens_hsa051460.62046401
85Thyroid cancer_Homo sapiens_hsa052160.59924778
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58124783
87Insulin signaling pathway_Homo sapiens_hsa049100.53843904
88MAPK signaling pathway_Homo sapiens_hsa040100.51921723
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51306657
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51210303
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50850067
92Phagosome_Homo sapiens_hsa041450.50582009
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.49202677
94Lysine degradation_Homo sapiens_hsa003100.47833363
95Estrogen signaling pathway_Homo sapiens_hsa049150.47520200
96Non-homologous end-joining_Homo sapiens_hsa034500.46699091
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46507968
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45593922
99Complement and coagulation cascades_Homo sapiens_hsa046100.44266111
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44097007

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