ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	6.03752027
2	regulation of mitotic spindle checkpoint (GO:1903504)	6.03752027
3	DNA deamination (GO:0045006)	4.86419779
4	mannosylation (GO:0097502)	4.83817235
5	chaperone-mediated protein transport (GO:0072321)	4.43837391
6	nucleotide transmembrane transport (GO:1901679)	4.07862327
7	negative regulation of telomere maintenance (GO:0032205)	3.96277053
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.94675335
9	detection of light stimulus involved in visual perception (GO:0050908)	3.66978930
10	detection of light stimulus involved in sensory perception (GO:0050962)	3.66978930
11	preassembly of GPI anchor in ER membrane (GO:0016254)	3.65979875
12	multicellular organismal aging (GO:0010259)	3.64060952
13	protein polyglutamylation (GO:0018095)	3.61376396
14	GPI anchor metabolic process (GO:0006505)	3.60285235
15	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.59639489
16	pyrimidine dimer repair (GO:0006290)	3.58663711
17	dendritic spine morphogenesis (GO:0060997)	3.53037672
18	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.48619583
19	DNA excision (GO:0044349)	3.46325741
20	nucleotide-excision repair, DNA damage removal (GO:0000718)	3.46325741
21	GPI anchor biosynthetic process (GO:0006506)	3.46193135
22	neural tube formation (GO:0001841)	3.44706800
23	S-adenosylmethionine metabolic process (GO:0046500)	3.43993123
24	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.43291409
25	regulation of cilium movement (GO:0003352)	3.42037595
26	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.38230599
27	replication fork processing (GO:0031297)	3.37003439
28	termination of RNA polymerase I transcription (GO:0006363)	3.35312076
29	protein deneddylation (GO:0000338)	3.33937595
30	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.31460211
31	centriole replication (GO:0007099)	3.27892752
32	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.21773284
33	negative regulation of heart rate (GO:0010459)	3.17427242
34	kynurenine metabolic process (GO:0070189)	3.16260038
35	organelle disassembly (GO:1903008)	3.14621939
36	peptidyl-histidine modification (GO:0018202)	3.14019826
37	nonmotile primary cilium assembly (GO:0035058)	3.11798269
38	C-terminal protein lipidation (GO:0006501)	3.06386656
39	endoderm formation (GO:0001706)	3.04954901
40	ATP synthesis coupled proton transport (GO:0015986)	2.97196835
41	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.97196835
42	platelet dense granule organization (GO:0060155)	2.95911068
43	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.93210953
44	ribonucleoprotein complex disassembly (GO:0032988)	2.92848661
45	negative regulation of response to food (GO:0032096)	2.92582631
46	negative regulation of appetite (GO:0032099)	2.92582631
47	detection of temperature stimulus involved in sensory perception (GO:0050961)	2.91638375
48	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	2.91638375
49	amino acid salvage (GO:0043102)	2.91276776
50	L-methionine salvage (GO:0071267)	2.91276776
51	L-methionine biosynthetic process (GO:0071265)	2.91276776
52	C-terminal protein amino acid modification (GO:0018410)	2.90605516
53	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.88979926
54	multicellular organism reproduction (GO:0032504)	2.88872379
55	fucose catabolic process (GO:0019317)	2.88355274
56	L-fucose metabolic process (GO:0042354)	2.88355274
57	L-fucose catabolic process (GO:0042355)	2.88355274
58	ubiquinone biosynthetic process (GO:0006744)	2.87549413
59	retinal ganglion cell axon guidance (GO:0031290)	2.87275307
60	sympathetic nervous system development (GO:0048485)	2.86600831
61	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.86452455
62	behavioral response to nicotine (GO:0035095)	2.85819398
63	maturation of SSU-rRNA (GO:0030490)	2.83380044
64	cilium morphogenesis (GO:0060271)	2.82549865
65	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.82202465
66	cardiac right ventricle morphogenesis (GO:0003215)	2.81317948
67	transcription from RNA polymerase I promoter (GO:0006360)	2.81108930
68	regulation of microtubule-based movement (GO:0060632)	2.79076544
69	tryptophan catabolic process (GO:0006569)	2.78057458
70	indole-containing compound catabolic process (GO:0042436)	2.78057458
71	indolalkylamine catabolic process (GO:0046218)	2.78057458
72	wound healing, spreading of epidermal cells (GO:0035313)	2.78046039
73	regulation of spindle checkpoint (GO:0090231)	2.76957250
74	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.75409500
75	regulation of coenzyme metabolic process (GO:0051196)	2.74010656
76	regulation of cofactor metabolic process (GO:0051193)	2.74010656
77	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.73521534
78	ubiquinone metabolic process (GO:0006743)	2.73357436
79	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.70873117
80	mitotic cell cycle arrest (GO:0071850)	2.68563548
81	cellular ketone body metabolic process (GO:0046950)	2.67813167
82	glycolipid biosynthetic process (GO:0009247)	2.67757847
83	photoreceptor cell maintenance (GO:0045494)	2.64613751
84	respiratory chain complex IV assembly (GO:0008535)	2.63402638
85	metallo-sulfur cluster assembly (GO:0031163)	2.62989316
86	iron-sulfur cluster assembly (GO:0016226)	2.62989316
87	aggressive behavior (GO:0002118)	2.57569456
88	reciprocal meiotic recombination (GO:0007131)	2.56912431
89	reciprocal DNA recombination (GO:0035825)	2.56912431
90	indolalkylamine metabolic process (GO:0006586)	2.55084221
91	regulation of telomere maintenance (GO:0032204)	2.54983232
92	rRNA modification (GO:0000154)	2.54880457
93	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.54349680
94	cullin deneddylation (GO:0010388)	2.53738084
95	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.53418910
96	termination of RNA polymerase III transcription (GO:0006386)	2.53418910
97	7-methylguanosine mRNA capping (GO:0006370)	2.49812557
98	positive regulation of mitochondrial fission (GO:0090141)	2.49390908
99	urogenital system development (GO:0001655)	2.49205653
100	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.47540813

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.15198423
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.88188435
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.51466455
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.34993196
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.17983743
6	VDR_22108803_ChIP-Seq_LS180_Human	2.78966050
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.78060202
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.67899585
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.62709222
10	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.47193735
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.40210168
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.32443344
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.31164105
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.26959840
15	EWS_26573619_Chip-Seq_HEK293_Human	2.18379161
16	IRF1_19129219_ChIP-ChIP_H3396_Human	2.17122522
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.13321221
18	EZH2_22144423_ChIP-Seq_EOC_Human	2.10339175
19	TP53_22573176_ChIP-Seq_HFKS_Human	1.98211085
20	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.90064975
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.89798853
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.88489405
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.87831806
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.83560348
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.83401037
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.81631537
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78888175
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.70295905
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.68899170
30	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.68589401
31	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.61737408
32	P300_19829295_ChIP-Seq_ESCs_Human	1.56503031
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.55659053
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.53132262
35	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.50630531
36	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.43646373
37	IGF1R_20145208_ChIP-Seq_DFB_Human	1.32766845
38	FUS_26573619_Chip-Seq_HEK293_Human	1.31034607
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30113477
40	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.27302738
41	TAF15_26573619_Chip-Seq_HEK293_Human	1.27158619
42	ERA_21632823_ChIP-Seq_H3396_Human	1.27071511
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26308269
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.26199531
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.24476966
46	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.21094575
47	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19159792
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18262951
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18262951
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17299601
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.17253783
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17181721
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17181721
54	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.16063549
55	STAT1_20625510_ChIP-Seq_HELA_Human	1.15693085
56	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.15246565
57	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.15052505
58	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14919686
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.14511361
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.14241200
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14241200
62	CIITA_25753668_ChIP-Seq_RAJI_Human	1.14163082
63	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.14014726
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.10874073
65	NCOR_22424771_ChIP-Seq_293T_Human	1.10497404
66	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.10323944
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09887887
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09153148
69	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.08725729
70	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.08494096
71	RBPJ_21746931_ChIP-Seq_IB4_Human	1.08356545
72	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.07360292
73	GATA3_26560356_Chip-Seq_TH2_Human	1.06757078
74	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05476510
75	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.04562219
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04529196
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.04488569
78	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03310366
79	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02679070
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02055038
81	AR_20517297_ChIP-Seq_VCAP_Human	1.01304325
82	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00591752
83	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.99497555
84	CDX2_22108803_ChIP-Seq_LS180_Human	0.99080569
85	RNF2_27304074_Chip-Seq_NSC_Mouse	0.98946757
86	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97670095
87	AR_25329375_ChIP-Seq_VCAP_Human	0.97626602
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96533479
89	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.95074882
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95025379
91	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.94512377
92	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94456469
93	GBX2_23144817_ChIP-Seq_PC3_Human	0.93808715
94	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.92272786
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.92179981
96	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.91634474
97	PHF8_20622853_ChIP-Seq_HELA_Human	0.91186810
98	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.90960749
99	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.90716028
100	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.89475401

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.43894557
2	MP0006072_abnormal_retinal_apoptosis	3.99552140
3	MP0004147_increased_porphyrin_level	3.37011543
4	MP0008877_abnormal_DNA_methylation	3.21954891
5	MP0003880_abnormal_central_pattern	2.72994908
6	MP0003787_abnormal_imprinting	2.69222258
7	MP0002138_abnormal_hepatobiliary_system	2.61589229
8	MP0006276_abnormal_autonomic_nervous	2.37780401
9	MP0003724_increased_susceptibility_to	2.31822725
10	MP0005423_abnormal_somatic_nervous	2.22578367
11	MP0002837_dystrophic_cardiac_calcinosis	2.13887650
12	MP0001661_extended_life_span	2.13317534
13	MP0006292_abnormal_olfactory_placode	2.03654342
14	MP0004133_heterotaxia	2.00194351
15	MP0008789_abnormal_olfactory_epithelium	1.98120657
16	MP0005253_abnormal_eye_physiology	1.89569992
17	MP0005551_abnormal_eye_electrophysiolog	1.88369962
18	MP0008775_abnormal_heart_ventricle	1.87326847
19	MP0001529_abnormal_vocalization	1.85424360
20	MP0004145_abnormal_muscle_electrophysio	1.85062943
21	MP0002751_abnormal_autonomic_nervous	1.83729357
22	MP0003646_muscle_fatigue	1.78142468
23	MP0002928_abnormal_bile_duct	1.77629949
24	MP0000372_irregular_coat_pigmentation	1.75448933
25	MP0004885_abnormal_endolymph	1.72897971
26	MP0002736_abnormal_nociception_after	1.67525746
27	MP0008058_abnormal_DNA_repair	1.64509795
28	MP0005367_renal/urinary_system_phenotyp	1.63204746
29	MP0000516_abnormal_urinary_system	1.63204746
30	MP0001968_abnormal_touch/_nociception	1.57253237
31	MP0003252_abnormal_bile_duct	1.56120138
32	MP0003786_premature_aging	1.50699916
33	MP0002090_abnormal_vision	1.49895721
34	MP0002272_abnormal_nervous_system	1.40657910
35	MP0001293_anophthalmia	1.40583081
36	MP0006036_abnormal_mitochondrial_physio	1.40506836
37	MP0005499_abnormal_olfactory_system	1.40468557
38	MP0005394_taste/olfaction_phenotype	1.40468557
39	MP0006035_abnormal_mitochondrial_morpho	1.36407666
40	MP0003011_delayed_dark_adaptation	1.36402660
41	MP0001986_abnormal_taste_sensitivity	1.36112957
42	MP0008872_abnormal_physiological_respon	1.33085171
43	MP0002234_abnormal_pharynx_morphology	1.32939782
44	MP0004142_abnormal_muscle_tone	1.31432211
45	MP0001835_abnormal_antigen_presentation	1.30931534
46	MP0003567_abnormal_fetal_cardiomyocyte	1.30269516
47	MP0002095_abnormal_skin_pigmentation	1.30152510
48	MP0005377_hearing/vestibular/ear_phenot	1.30149469
49	MP0003878_abnormal_ear_physiology	1.30149469
50	MP0001485_abnormal_pinna_reflex	1.26250173
51	MP0009046_muscle_twitch	1.25943380
52	MP0004043_abnormal_pH_regulation	1.23227126
53	MP0005075_abnormal_melanosome_morpholog	1.18808255
54	MP0002638_abnormal_pupillary_reflex	1.18726856
55	MP0002396_abnormal_hematopoietic_system	1.17869246
56	MP0008007_abnormal_cellular_replicative	1.16133596
57	MP0005084_abnormal_gallbladder_morpholo	1.14011459
58	MP0000230_abnormal_systemic_arterial	1.08412893
59	MP0005671_abnormal_response_to	1.05454574
60	MP0005391_vision/eye_phenotype	1.03907052
61	MP0008875_abnormal_xenobiotic_pharmacok	1.03249452
62	MP0001502_abnormal_circadian_rhythm	1.01347439
63	MP0010386_abnormal_urinary_bladder	0.98489400
64	MP0001800_abnormal_humoral_immune	0.95911780
65	MP0005171_absent_coat_pigmentation	0.93870924
66	MP0002938_white_spotting	0.93713893
67	MP0000778_abnormal_nervous_system	0.92784939
68	MP0004924_abnormal_behavior	0.88273654
69	MP0005386_behavior/neurological_phenoty	0.88273654
70	MP0008260_abnormal_autophagy	0.84974922
71	MP0005085_abnormal_gallbladder_physiolo	0.84353710
72	MP0005410_abnormal_fertilization	0.82476332
73	MP0001486_abnormal_startle_reflex	0.81553531
74	MP0000358_abnormal_cell_content/	0.81417836
75	MP0002733_abnormal_thermal_nociception	0.81318660
76	MP0000538_abnormal_urinary_bladder	0.79402277
77	MP0003718_maternal_effect	0.73796016
78	MP0002653_abnormal_ependyma_morphology	0.72990296
79	MP0001919_abnormal_reproductive_system	0.71647128
80	MP0005195_abnormal_posterior_eye	0.71351873
81	MP0001905_abnormal_dopamine_level	0.71237497
82	MP0003195_calcinosis	0.70119535
83	MP0005389_reproductive_system_phenotype	0.69878665
84	MP0000955_abnormal_spinal_cord	0.68710013
85	MP0003186_abnormal_redox_activity	0.67216316
86	MP0002009_preneoplasia	0.66074027
87	MP0005332_abnormal_amino_acid	0.65835727
88	MP0000685_abnormal_immune_system	0.64884931
89	MP0004215_abnormal_myocardial_fiber	0.64351511
90	MP0005220_abnormal_exocrine_pancreas	0.63035051
91	MP0009379_abnormal_foot_pigmentation	0.62909487
92	MP0002752_abnormal_somatic_nervous	0.61549740
93	MP0003866_abnormal_defecation	0.60003480
94	MP0002909_abnormal_adrenal_gland	0.59781143
95	MP0001501_abnormal_sleep_pattern	0.59155377
96	MP0000631_abnormal_neuroendocrine_gland	0.59055843
97	MP0002557_abnormal_social/conspecific_i	0.59000549
98	MP0005670_abnormal_white_adipose	0.58833785
99	MP0002876_abnormal_thyroid_physiology	0.58581927
100	MP0002723_abnormal_immune_serum	0.57335206

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.46948356
2	Type II lissencephaly (HP:0007260)	3.63289876
3	Thyroid-stimulating hormone excess (HP:0002925)	3.47419888
4	Acute necrotizing encephalopathy (HP:0006965)	3.29861656
5	Abnormal rod and cone electroretinograms (HP:0008323)	3.21745540
6	Abnormality of the labia minora (HP:0012880)	3.20323700
7	Cerebellar dysplasia (HP:0007033)	3.09315607
8	Duplicated collecting system (HP:0000081)	3.01255554
9	Mitochondrial inheritance (HP:0001427)	3.01106538
10	Abnormality of DNA repair (HP:0003254)	3.00606106
11	Increased CSF lactate (HP:0002490)	2.95485202
12	Hypomagnesemia (HP:0002917)	2.91387844
13	Acute encephalopathy (HP:0006846)	2.88822978
14	Bilateral microphthalmos (HP:0007633)	2.87678300
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.86800686
16	Hepatocellular necrosis (HP:0001404)	2.82221105
17	Type I transferrin isoform profile (HP:0003642)	2.77108555
18	Bony spicule pigmentary retinopathy (HP:0007737)	2.76674461
19	Stomach cancer (HP:0012126)	2.75881905
20	Abnormality of the renal collecting system (HP:0004742)	2.75122907
21	Pancreatic fibrosis (HP:0100732)	2.73594142
22	Chromsome breakage (HP:0040012)	2.71799583
23	Progressive macrocephaly (HP:0004481)	2.69395819
24	Medial flaring of the eyebrow (HP:0010747)	2.67619082
25	Stomatitis (HP:0010280)	2.66441189
26	Gait imbalance (HP:0002141)	2.62326781
27	Abnormal protein N-linked glycosylation (HP:0012347)	2.56794897
28	Abnormal protein glycosylation (HP:0012346)	2.56794897
29	Abnormal glycosylation (HP:0012345)	2.56794897
30	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.56794897
31	Abolished electroretinogram (ERG) (HP:0000550)	2.55111883
32	Constricted visual fields (HP:0001133)	2.53872248
33	Nephrogenic diabetes insipidus (HP:0009806)	2.50055470
34	Congenital primary aphakia (HP:0007707)	2.47956115
35	Pancreatic cysts (HP:0001737)	2.45013032
36	Molar tooth sign on MRI (HP:0002419)	2.42615177
37	Abnormality of midbrain morphology (HP:0002418)	2.42615177
38	Nephronophthisis (HP:0000090)	2.42056452
39	Increased serum lactate (HP:0002151)	2.40280562
40	Abnormality of the prostate (HP:0008775)	2.39876574
41	Anterior segment dysgenesis (HP:0007700)	2.32616627
42	Hepatic necrosis (HP:0002605)	2.31343648
43	Increased serum pyruvate (HP:0003542)	2.30989873
44	Reticulocytopenia (HP:0001896)	2.30404337
45	Inability to walk (HP:0002540)	2.29817109
46	Prostate neoplasm (HP:0100787)	2.27549766
47	Abnormality of the renal medulla (HP:0100957)	2.25806599
48	Absent thumb (HP:0009777)	2.23949214
49	CNS hypomyelination (HP:0003429)	2.23885582
50	Chorioretinal atrophy (HP:0000533)	2.23206458
51	Neonatal respiratory distress (HP:0002643)	2.19726046
52	True hermaphroditism (HP:0010459)	2.17126055
53	Retinal dysplasia (HP:0007973)	2.15307642
54	Parakeratosis (HP:0001036)	2.14230631
55	Lipid accumulation in hepatocytes (HP:0006561)	2.12313887
56	Anomalous pulmonary venous return (HP:0010772)	2.10904182
57	Hyperuricemia (HP:0002149)	2.09213781
58	Increased purine levels (HP:0004368)	2.09213781
59	Abnormality of magnesium homeostasis (HP:0004921)	2.07637767
60	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.03018563
61	Methylmalonic acidemia (HP:0002912)	2.01729847
62	Megalencephaly (HP:0001355)	2.01085854
63	Metaphyseal dysplasia (HP:0100255)	1.99396278
64	Cerebral edema (HP:0002181)	1.98290837
65	Abnormality of alanine metabolism (HP:0010916)	1.97812925
66	Hyperalaninemia (HP:0003348)	1.97812925
67	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.97812925
68	Abnormality of glycolysis (HP:0004366)	1.97452697
69	Neutropenia (HP:0001875)	1.95846242
70	Abnormality of purine metabolism (HP:0004352)	1.95696912
71	Renal Fanconi syndrome (HP:0001994)	1.95643534
72	Lactic acidosis (HP:0003128)	1.94763708
73	Abnormality of cochlea (HP:0000375)	1.93235237
74	Poikiloderma (HP:0001029)	1.91793278
75	Asplenia (HP:0001746)	1.91789100
76	Increased hepatocellular lipid droplets (HP:0006565)	1.91354308
77	Alveolar cell carcinoma (HP:0006519)	1.89301511
78	Attenuation of retinal blood vessels (HP:0007843)	1.86885543
79	Genital tract atresia (HP:0001827)	1.86853291
80	Horseshoe kidney (HP:0000085)	1.86553603
81	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.86440815
82	Optic disc pallor (HP:0000543)	1.86188677
83	Lissencephaly (HP:0001339)	1.85213609
84	Vaginal atresia (HP:0000148)	1.85015654
85	IgG deficiency (HP:0004315)	1.84466183
86	Cortical visual impairment (HP:0100704)	1.83391885
87	Hypothermia (HP:0002045)	1.82249264
88	Abnormality of the metopic suture (HP:0005556)	1.81061628
89	Polydipsia (HP:0001959)	1.81018047
90	Abnormal drinking behavior (HP:0030082)	1.81018047
91	Supernumerary spleens (HP:0009799)	1.80363742
92	Abnormality of the pulmonary veins (HP:0011718)	1.79749696
93	Progressive microcephaly (HP:0000253)	1.79014122
94	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.78842903
95	Polyphagia (HP:0002591)	1.78109216
96	Disproportionate short-trunk short stature (HP:0003521)	1.76579081
97	Hydroxyprolinuria (HP:0003080)	1.75677486
98	Abnormality of proline metabolism (HP:0010907)	1.75677486
99	Polyuria (HP:0000103)	1.75034347
100	Postaxial hand polydactyly (HP:0001162)	1.74551507

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK8	3.75374224
2	MST4	3.73436088
3	PDK2	3.41144239
4	PLK4	3.12902316
5	NUAK1	3.12894262
6	WNK4	2.75184257
7	ADRBK2	2.74770949
8	ZAK	2.68064686
9	TIE1	2.63634119
10	PLK2	2.16815824
11	MAP2K2	2.14299332
12	FLT3	2.08053145
13	TLK1	1.98183332
14	DYRK3	1.90792829
15	GRK1	1.89668332
16	SIK3	1.79293062
17	BMPR1B	1.63849612
18	MAP4K2	1.63447492
19	WNK3	1.62897814
20	DYRK2	1.58899264
21	MATK	1.54326067
22	STK39	1.50358153
23	FRK	1.50103760
24	MAP4K1	1.43896181
25	TSSK6	1.38375913
26	KIT	1.24789845
27	OXSR1	1.24136936
28	PAK3	1.14676476
29	TXK	1.12372533
30	TNK2	1.12090210
31	ERBB2	1.10857629
32	NTRK2	1.10149850
33	STK16	1.09980858
34	PRKCQ	1.03391960
35	SIK2	1.01906652
36	EIF2AK3	1.00743786
37	VRK1	0.98017313
38	TESK1	0.97567971
39	EPHB2	0.93373803
40	MAPK13	0.93321161
41	PLK3	0.91569713
42	EIF2AK2	0.91218712
43	GRK6	0.88700783
44	MARK1	0.86478883
45	NTRK3	0.85447075
46	TEC	0.79358456
47	MAP2K1	0.78826413
48	INSRR	0.78671524
49	SRPK1	0.75818688
50	BMPR2	0.74782525
51	ILK	0.73562229
52	PHKG1	0.73439735
53	PHKG2	0.73439735
54	IKBKE	0.69167877
55	DAPK2	0.67707202
56	RPS6KA2	0.66496964
57	PINK1	0.65402856
58	VRK2	0.65101391
59	PRKCE	0.64477582
60	BCKDK	0.62293464
61	NTRK1	0.61559712
62	CSNK1G3	0.60380427
63	CSNK1G1	0.60059464
64	TAOK3	0.60004955
65	PIK3CG	0.57935890
66	CSNK1A1L	0.56642155
67	CSNK1G2	0.56302883
68	IKBKB	0.52728046
69	RPS6KA4	0.52152872
70	ITK	0.51187197
71	IRAK4	0.50503144
72	ERBB3	0.50265883
73	STK10	0.50236610
74	PAK6	0.50012494
75	ATR	0.48977636
76	TRPM7	0.48700322
77	TRIM28	0.48329128
78	SYK	0.44921892
79	RPS6KB2	0.44739665
80	RPS6KA5	0.44518484
81	SGK223	0.44007782
82	SGK494	0.44007782
83	CDK9	0.42625892
84	ADRBK1	0.42351635
85	PRKG1	0.42079630
86	MAP3K8	0.41601270
87	PKN1	0.40799795
88	MAPK12	0.35808350
89	LCK	0.35628399
90	IGF1R	0.35464892
91	CSF1R	0.35210344
92	CAMK1D	0.34038897
93	ATM	0.32540499
94	PRKCG	0.32254109
95	MKNK1	0.30830308
96	NEK6	0.30766877
97	CSNK2A1	0.30722240
98	ROCK2	0.28836320
99	CSNK1A1	0.28055231
100	CAMK2A	0.27117798

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.14690677
2	Asthma_Homo sapiens_hsa05310	3.13933954
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.12310498
4	Protein export_Homo sapiens_hsa03060	2.73219344
5	Basal transcription factors_Homo sapiens_hsa03022	2.58822713
6	Allograft rejection_Homo sapiens_hsa05330	2.56298896
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.45114641
8	Proteasome_Homo sapiens_hsa03050	2.44193089
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.41811958
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.35622490
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.27257941
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.19772070
13	RNA polymerase_Homo sapiens_hsa03020	2.16136218
14	Parkinsons disease_Homo sapiens_hsa05012	2.11561564
15	Homologous recombination_Homo sapiens_hsa03440	2.07307929
16	RNA degradation_Homo sapiens_hsa03018	2.04157970
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.03236122
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.95378288
19	Propanoate metabolism_Homo sapiens_hsa00640	1.86539332
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.79605907
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.72912745
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.61262908
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.54311265
24	Regulation of autophagy_Homo sapiens_hsa04140	1.53091500
25	Sulfur metabolism_Homo sapiens_hsa00920	1.43267715
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40818371
27	Butanoate metabolism_Homo sapiens_hsa00650	1.30645841
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.27927842
29	Ribosome_Homo sapiens_hsa03010	1.19763578
30	One carbon pool by folate_Homo sapiens_hsa00670	1.16398421
31	Sulfur relay system_Homo sapiens_hsa04122	1.15128646
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.14572920
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.11628527
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.11040492
35	Huntingtons disease_Homo sapiens_hsa05016	1.09149373
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.08081796
37	Non-homologous end-joining_Homo sapiens_hsa03450	1.06709092
38	Alzheimers disease_Homo sapiens_hsa05010	1.03007716
39	Pyruvate metabolism_Homo sapiens_hsa00620	0.99994883
40	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99213186
41	Fatty acid degradation_Homo sapiens_hsa00071	0.98819822
42	Antigen processing and presentation_Homo sapiens_hsa04612	0.98208601
43	Folate biosynthesis_Homo sapiens_hsa00790	0.97138356
44	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.95845429
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.95613450
46	Viral myocarditis_Homo sapiens_hsa05416	0.94573736
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.94434747
48	Steroid biosynthesis_Homo sapiens_hsa00100	0.91493276
49	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.91379600
50	Phototransduction_Homo sapiens_hsa04744	0.90261252
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87635710
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.87042119
53	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.83391150
54	RNA transport_Homo sapiens_hsa03013	0.82745226
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80984634
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.80974795
57	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.78629867
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.76959292
59	Fatty acid elongation_Homo sapiens_hsa00062	0.74460006
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.74366742
61	Morphine addiction_Homo sapiens_hsa05032	0.71972376
62	Peroxisome_Homo sapiens_hsa04146	0.71685703
63	Primary immunodeficiency_Homo sapiens_hsa05340	0.68643094
64	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.68609378
65	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.67700366
66	Selenocompound metabolism_Homo sapiens_hsa00450	0.66670882
67	Purine metabolism_Homo sapiens_hsa00230	0.63624207
68	Taste transduction_Homo sapiens_hsa04742	0.61900816
69	Serotonergic synapse_Homo sapiens_hsa04726	0.61339927
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61259111
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.61192277
72	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60935532
73	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.60460513
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58028161
75	Arginine biosynthesis_Homo sapiens_hsa00220	0.57687821
76	Caffeine metabolism_Homo sapiens_hsa00232	0.56578820
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56090913
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.55101581
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55056013
80	Metabolic pathways_Homo sapiens_hsa01100	0.53762004
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52522461
82	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.51725499
83	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.51554298
84	Retinol metabolism_Homo sapiens_hsa00830	0.49739174
85	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49439682
86	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.49324752
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47100238
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.46674555
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46589788
90	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46532868
91	Mismatch repair_Homo sapiens_hsa03430	0.44288623
92	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.42039580
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41695247
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.37788365
95	Olfactory transduction_Homo sapiens_hsa04740	0.33602276
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32873872
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.32466900
98	Renin secretion_Homo sapiens_hsa04924	0.32180022
99	Leishmaniasis_Homo sapiens_hsa05140	0.31274428
100	Nicotine addiction_Homo sapiens_hsa05033	0.30794619

HNRNPA1P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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