ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.41330221
2	response to pheromone (GO:0019236)	5.39353173
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.40119895
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.05894284
5	DNA double-strand break processing (GO:0000729)	3.99999479
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.93747981
7	ATP synthesis coupled proton transport (GO:0015986)	3.93747981
8	regulation of chronic inflammatory response (GO:0002676)	3.88992808
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.86267009
10	proteasome assembly (GO:0043248)	3.65773092
11	cytidine catabolic process (GO:0006216)	3.61132291
12	cytidine deamination (GO:0009972)	3.61132291
13	cytidine metabolic process (GO:0046087)	3.61132291
14	ribosomal small subunit assembly (GO:0000028)	3.60849851
15	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.57389264
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.55190112
17	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.54021793
18	urate metabolic process (GO:0046415)	3.50588798
19	platelet dense granule organization (GO:0060155)	3.48949052
20	regulation of cellular amino acid metabolic process (GO:0006521)	3.48615583
21	protein neddylation (GO:0045116)	3.41813801
22	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.40759223
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.35626880
24	rRNA modification (GO:0000154)	3.31865159
25	mitochondrial respiratory chain complex assembly (GO:0033108)	3.28491743
26	actin nucleation (GO:0045010)	3.28020128
27	base-excision repair, AP site formation (GO:0006285)	3.24864186
28	protein complex biogenesis (GO:0070271)	3.23537034
29	adenosine metabolic process (GO:0046085)	3.19999068
30	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.19620623
31	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.18450676
32	cornea development in camera-type eye (GO:0061303)	3.13278614
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.11052707
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.11052707
35	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.11020059
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.10630872
37	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.10630872
38	NADH dehydrogenase complex assembly (GO:0010257)	3.10630872
39	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.09664543
40	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.09664543
41	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.09664543
42	negative regulation of mast cell activation (GO:0033004)	3.07464266
43	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.07349623
44	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.07349623
45	DNA catabolic process, exonucleolytic (GO:0000738)	3.04005242
46	GTP biosynthetic process (GO:0006183)	3.01381449
47	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.98049679
48	negative regulation of ligase activity (GO:0051352)	2.96399107
49	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.96399107
50	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.92772896
51	pseudouridine synthesis (GO:0001522)	2.92182605
52	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.91211189
53	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.90275445
54	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.90275445
55	purine-containing compound salvage (GO:0043101)	2.90159218
56	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.87402470
57	mitochondrial RNA metabolic process (GO:0000959)	2.83016138
58	protein-cofactor linkage (GO:0018065)	2.82409678
59	replication fork processing (GO:0031297)	2.77521603
60	L-fucose metabolic process (GO:0042354)	2.74214229
61	L-fucose catabolic process (GO:0042355)	2.74214229
62	fucose catabolic process (GO:0019317)	2.74214229
63	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.72312315
64	purine nucleotide salvage (GO:0032261)	2.69723782
65	chaperone-mediated protein transport (GO:0072321)	2.68530784
66	protein polyglutamylation (GO:0018095)	2.66986606
67	sequestering of actin monomers (GO:0042989)	2.66052871
68	positive regulation of prostaglandin secretion (GO:0032308)	2.64470466
69	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.63641871
70	rRNA methylation (GO:0031167)	2.63635966
71	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.63408551
72	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.61435117
73	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.61174103
74	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.57932759
75	rRNA catabolic process (GO:0016075)	2.57749383
76	electron transport chain (GO:0022900)	2.56172689
77	purine deoxyribonucleotide catabolic process (GO:0009155)	2.55886104
78	S-adenosylmethionine metabolic process (GO:0046500)	2.55820609
79	cellular ketone body metabolic process (GO:0046950)	2.55540875
80	tRNA processing (GO:0008033)	2.55475761
81	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.54265343
82	respiratory electron transport chain (GO:0022904)	2.54159846
83	response to interferon-beta (GO:0035456)	2.53978643
84	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.52346778
85	cullin deneddylation (GO:0010388)	2.51958317
86	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.51901650
87	positive regulation of ligase activity (GO:0051351)	2.51122212
88	regulation of cellular amine metabolic process (GO:0033238)	2.47501607
89	negative T cell selection (GO:0043383)	2.47469138
90	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.47417613
91	IMP biosynthetic process (GO:0006188)	2.47051149
92	tRNA modification (GO:0006400)	2.46830558
93	protein deneddylation (GO:0000338)	2.46811794
94	adaptation of signaling pathway (GO:0023058)	2.45760622
95	peptidyl-histidine modification (GO:0018202)	2.45532511
96	iron-sulfur cluster assembly (GO:0016226)	2.45061838
97	metallo-sulfur cluster assembly (GO:0031163)	2.45061838
98	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.44770272
99	GMP metabolic process (GO:0046037)	2.43427767
100	guanosine-containing compound biosynthetic process (GO:1901070)	2.42570436

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.69405428
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.68833002
3	VDR_22108803_ChIP-Seq_LS180_Human	3.36660970
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.12385211
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.01752247
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.75539591
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.75384439
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.74453066
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.61341893
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.51514954
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.49913613
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.42617053
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.41446084
14	EWS_26573619_Chip-Seq_HEK293_Human	2.10671756
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.07909488
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.06028743
17	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.04400171
18	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.03370504
19	MYC_18940864_ChIP-ChIP_HL60_Human	2.00356182
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.94982645
21	EZH2_22144423_ChIP-Seq_EOC_Human	1.94470634
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.94068063
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.93268084
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.92562094
25	FUS_26573619_Chip-Seq_HEK293_Human	1.90706206
26	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.90641086
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.89833643
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.87250208
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86382226
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.80949609
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.80173477
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.79492871
33	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.77695764
34	P300_19829295_ChIP-Seq_ESCs_Human	1.76840819
35	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.71987637
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.71497020
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.64450392
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54156451
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.52059721
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.52059721
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.50564769
42	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.48743368
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.48740801
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.47306164
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.46105415
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46105415
47	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.44952891
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43818230
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43818230
50	GATA3_26560356_Chip-Seq_TH2_Human	1.39313740
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.38917587
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38553951
53	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.35178690
54	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.33119921
55	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.29685890
56	AR_20517297_ChIP-Seq_VCAP_Human	1.28072208
57	MYB_26560356_Chip-Seq_TH2_Human	1.21421324
58	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.21006618
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19323606
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18856383
61	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.16850049
62	NCOR_22424771_ChIP-Seq_293T_Human	1.16334857
63	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.15738269
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15627956
65	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.15357698
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15235789
67	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.14095933
68	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.14093643
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.13767285
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12242517
71	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11864486
72	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11666852
73	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.10737251
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09742032
75	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09504149
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.08824981
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08470072
78	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.08314855
79	BCAT_22108803_ChIP-Seq_LS180_Human	1.05273629
80	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.04927229
81	DCP1A_22483619_ChIP-Seq_HELA_Human	1.03562184
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02985010
83	GBX2_23144817_ChIP-Seq_PC3_Human	1.02578916
84	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.01769004
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00201464
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98564998
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.97419665
88	GABP_19822575_ChIP-Seq_HepG2_Human	0.94815360
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.94465211
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.92718207
91	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.92356052
92	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92115360
93	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91944119
94	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.91308712
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.90897769
96	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90868060
97	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.90321089
98	CDX2_22108803_ChIP-Seq_LS180_Human	0.89572232
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.87843577
100	AR_25329375_ChIP-Seq_VCAP_Human	0.87472491

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.74748038
2	MP0008877_abnormal_DNA_methylation	3.39920019
3	MP0006072_abnormal_retinal_apoptosis	3.14759892
4	MP0004147_increased_porphyrin_level	3.07846849
5	MP0006292_abnormal_olfactory_placode	3.03215317
6	MP0001835_abnormal_antigen_presentation	2.60989199
7	MP0002166_altered_tumor_susceptibility	2.31499529
8	MP0003011_delayed_dark_adaptation	2.28563054
9	MP0008058_abnormal_DNA_repair	2.15930344
10	MP0003786_premature_aging	2.15009410
11	MP0003195_calcinosis	2.06926458
12	MP0005551_abnormal_eye_electrophysiolog	2.01118112
13	MP0009785_altered_susceptibility_to	1.95499446
14	MP0000372_irregular_coat_pigmentation	1.94545292
15	MP0008872_abnormal_physiological_respon	1.87820042
16	MP0002006_tumorigenesis	1.83102186
17	MP0005084_abnormal_gallbladder_morpholo	1.82319011
18	MP0002736_abnormal_nociception_after	1.80605015
19	MP0001968_abnormal_touch/_nociception	1.79261894
20	MP0005645_abnormal_hypothalamus_physiol	1.77992343
21	MP0005253_abnormal_eye_physiology	1.72148248
22	MP0003646_muscle_fatigue	1.71900306
23	MP0001986_abnormal_taste_sensitivity	1.66665878
24	MP0002102_abnormal_ear_morphology	1.59965783
25	MP0003787_abnormal_imprinting	1.58989109
26	MP0001873_stomach_inflammation	1.57734079
27	MP0000685_abnormal_immune_system	1.53905983
28	MP0010094_abnormal_chromosome_stability	1.48948553
29	MP0002160_abnormal_reproductive_system	1.46785148
30	MP0003567_abnormal_fetal_cardiomyocyte	1.46766819
31	MP0002148_abnormal_hypersensitivity_rea	1.46544756
32	MP0005389_reproductive_system_phenotype	1.45199395
33	MP0001800_abnormal_humoral_immune	1.40337344
34	MP0001919_abnormal_reproductive_system	1.37341462
35	MP0008995_early_reproductive_senescence	1.35017280
36	MP0009333_abnormal_splenocyte_physiolog	1.34634765
37	MP0002138_abnormal_hepatobiliary_system	1.33546968
38	MP0003763_abnormal_thymus_physiology	1.33427522
39	MP0006036_abnormal_mitochondrial_physio	1.32294751
40	MP0001764_abnormal_homeostasis	1.31627509
41	MP0005000_abnormal_immune_tolerance	1.27215488
42	MP0002638_abnormal_pupillary_reflex	1.24660201
43	MP0008875_abnormal_xenobiotic_pharmacok	1.24339793
44	MP0009697_abnormal_copulation	1.22818555
45	MP0005646_abnormal_pituitary_gland	1.22118097
46	MP0004145_abnormal_muscle_electrophysio	1.17361516
47	MP0002723_abnormal_immune_serum	1.16342140
48	MP0002163_abnormal_gland_morphology	1.12989127
49	MP0002420_abnormal_adaptive_immunity	1.12851153
50	MP0002876_abnormal_thyroid_physiology	1.11640738
51	MP0003866_abnormal_defecation	1.11125684
52	MP0001819_abnormal_immune_cell	1.10248289
53	MP0005085_abnormal_gallbladder_physiolo	1.08229390
54	MP0004885_abnormal_endolymph	1.07633795
55	MP0006276_abnormal_autonomic_nervous	1.06091917
56	MP0001293_anophthalmia	1.04830531
57	MP0001486_abnormal_startle_reflex	1.03159301
58	MP0000689_abnormal_spleen_morphology	1.00461486
59	MP0005387_immune_system_phenotype	0.99675316
60	MP0001790_abnormal_immune_system	0.99675316
61	MP0003718_maternal_effect	0.98590200
62	MP0005410_abnormal_fertilization	0.97540654
63	MP0002398_abnormal_bone_marrow	0.94747439
64	MP0000716_abnormal_immune_system	0.94340156
65	MP0005379_endocrine/exocrine_gland_phen	0.92971062
66	MP0002272_abnormal_nervous_system	0.92365730
67	MP0002452_abnormal_antigen_presenting	0.92000751
68	MP0000703_abnormal_thymus_morphology	0.91415462
69	MP0003186_abnormal_redox_activity	0.91141070
70	MP0001529_abnormal_vocalization	0.90462223
71	MP0003806_abnormal_nucleotide_metabolis	0.89443218
72	MP0002837_dystrophic_cardiac_calcinosis	0.88392736
73	MP0005025_abnormal_response_to	0.88100497
74	MP0005075_abnormal_melanosome_morpholog	0.87771780
75	MP0003121_genomic_imprinting	0.87564122
76	MP0001905_abnormal_dopamine_level	0.86886325
77	MP0006035_abnormal_mitochondrial_morpho	0.86777359
78	MP0005636_abnormal_mineral_homeostasis	0.85074342
79	MP0002733_abnormal_thermal_nociception	0.84338960
80	MP0003693_abnormal_embryo_hatching	0.84318766
81	MP0002722_abnormal_immune_system	0.84309612
82	MP0004142_abnormal_muscle_tone	0.83305350
83	MP0001929_abnormal_gametogenesis	0.83013640
84	MP0000631_abnormal_neuroendocrine_gland	0.82364607
85	MP0003724_increased_susceptibility_to	0.81697992
86	MP0003137_abnormal_impulse_conducting	0.81041637
87	MP0002090_abnormal_vision	0.79061929
88	MP0009643_abnormal_urine_homeostasis	0.78163813
89	MP0010155_abnormal_intestine_physiology	0.75975952
90	MP0002429_abnormal_blood_cell	0.75698928
91	MP0001970_abnormal_pain_threshold	0.73382883
92	MP0001501_abnormal_sleep_pattern	0.73273808
93	MP0006082_CNS_inflammation	0.73123299
94	MP0001661_extended_life_span	0.72794074
95	MP0001845_abnormal_inflammatory_respons	0.72581946
96	MP0005310_abnormal_salivary_gland	0.72466864
97	MP0001485_abnormal_pinna_reflex	0.70936306
98	MP0009745_abnormal_behavioral_response	0.70826289
99	MP0002210_abnormal_sex_determination	0.70481005
100	MP0002938_white_spotting	0.70360683

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abolished electroretinogram (ERG) (HP:0000550)	4.06553231
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.89114598
3	Methylmalonic acidemia (HP:0002912)	3.71285265
4	Congenital stationary night blindness (HP:0007642)	3.53648952
5	3-Methylglutaconic aciduria (HP:0003535)	3.53477963
6	Acute necrotizing encephalopathy (HP:0006965)	3.52565066
7	IgG deficiency (HP:0004315)	3.34114675
8	Severe combined immunodeficiency (HP:0004430)	3.28284357
9	Mitochondrial inheritance (HP:0001427)	3.26270890
10	True hermaphroditism (HP:0010459)	3.25122379
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.23362960
12	Methylmalonic aciduria (HP:0012120)	3.23144558
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.19134426
14	Hypoproteinemia (HP:0003075)	3.19117647
15	Pancreatic cysts (HP:0001737)	3.03125358
16	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.01524284
17	Abnormality of alanine metabolism (HP:0010916)	3.01524284
18	Hyperalaninemia (HP:0003348)	3.01524284
19	Abnormality of B cell number (HP:0010975)	2.97546806
20	Pancreatic fibrosis (HP:0100732)	2.95813190
21	Increased CSF lactate (HP:0002490)	2.95323349
22	Progressive macrocephaly (HP:0004481)	2.94813427
23	Increased hepatocellular lipid droplets (HP:0006565)	2.92014532
24	Acute encephalopathy (HP:0006846)	2.90911097
25	Stomatitis (HP:0010280)	2.86530366
26	Aplastic anemia (HP:0001915)	2.86216311
27	Panhypogammaglobulinemia (HP:0003139)	2.80806345
28	Attenuation of retinal blood vessels (HP:0007843)	2.74786510
29	B lymphocytopenia (HP:0010976)	2.73243565
30	Nephronophthisis (HP:0000090)	2.69580748
31	Molar tooth sign on MRI (HP:0002419)	2.69454581
32	Abnormality of midbrain morphology (HP:0002418)	2.69454581
33	Renal cortical cysts (HP:0000803)	2.66290605
34	Hepatocellular necrosis (HP:0001404)	2.65518783
35	Lipid accumulation in hepatocytes (HP:0006561)	2.59148007
36	T lymphocytopenia (HP:0005403)	2.58293319
37	Thyroiditis (HP:0100646)	2.58061014
38	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.53002670
39	Decreased central vision (HP:0007663)	2.51221171
40	Cerebral edema (HP:0002181)	2.51162960
41	Abnormality of T cell number (HP:0011839)	2.50297367
42	Autoimmune hemolytic anemia (HP:0001890)	2.49677635
43	Combined immunodeficiency (HP:0005387)	2.49112183
44	Increased intramyocellular lipid droplets (HP:0012240)	2.48353200
45	Abnormality of vitamin B metabolism (HP:0004340)	2.39093674
46	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.36468968
47	Dicarboxylic aciduria (HP:0003215)	2.36468968
48	Abnormality of T cells (HP:0002843)	2.36252312
49	Renal Fanconi syndrome (HP:0001994)	2.35991795
50	Chronic hepatic failure (HP:0100626)	2.34238760
51	Increased serum lactate (HP:0002151)	2.33913363
52	Hepatic necrosis (HP:0002605)	2.33649814
53	Asplenia (HP:0001746)	2.31619326
54	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.31245159
55	Optic disc pallor (HP:0000543)	2.28776553
56	Dyschromatopsia (HP:0007641)	2.28635272
57	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.24040673
58	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.17629163
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.15453559
60	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.15453559
61	Abnormality of serum amino acid levels (HP:0003112)	2.13963285
62	Lactic acidosis (HP:0003128)	2.12728997
63	Pendular nystagmus (HP:0012043)	2.10547696
64	Aplasia/hypoplasia of the uterus (HP:0008684)	2.10219447
65	Hypoplasia of the uterus (HP:0000013)	2.08664491
66	Autoimmune thrombocytopenia (HP:0001973)	2.04057026
67	Elevated erythrocyte sedimentation rate (HP:0003565)	2.03901447
68	Abnormality of the renal medulla (HP:0100957)	1.98277596
69	Type I transferrin isoform profile (HP:0003642)	1.98256912
70	Exertional dyspnea (HP:0002875)	1.97828426
71	Lethargy (HP:0001254)	1.97594174
72	Abnormal protein glycosylation (HP:0012346)	1.96260193
73	Abnormal glycosylation (HP:0012345)	1.96260193
74	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.96260193
75	Abnormal protein N-linked glycosylation (HP:0012347)	1.96260193
76	Abnormality of eosinophils (HP:0001879)	1.95993490
77	Abnormality of the renal cortex (HP:0011035)	1.95070906
78	Abnormality of the prostate (HP:0008775)	1.94530500
79	Abnormality of T cell physiology (HP:0011840)	1.91758716
80	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.91572444
81	Confusion (HP:0001289)	1.91046059
82	Increased muscle lipid content (HP:0009058)	1.89326343
83	Prostate neoplasm (HP:0100787)	1.86605286
84	Testicular atrophy (HP:0000029)	1.86312342
85	Hyperglycinemia (HP:0002154)	1.83009311
86	Pancytopenia (HP:0001876)	1.81443391
87	Chronic diarrhea (HP:0002028)	1.80766415
88	Eosinophilia (HP:0001880)	1.79038939
89	Microvesicular hepatic steatosis (HP:0001414)	1.77922100
90	Supernumerary spleens (HP:0009799)	1.76950502
91	Short tibia (HP:0005736)	1.76358571
92	Cerebral palsy (HP:0100021)	1.75884973
93	Male pseudohermaphroditism (HP:0000037)	1.75028020
94	Exercise intolerance (HP:0003546)	1.74932585
95	Medial flaring of the eyebrow (HP:0010747)	1.74179329
96	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.73727334
97	Colon cancer (HP:0003003)	1.73624355
98	Abnormality of purine metabolism (HP:0004352)	1.70704068
99	Congenital, generalized hypertrichosis (HP:0004540)	1.69062452
100	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.69015124

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	3.58834351
2	TXK	3.34793199
3	PBK	2.88147934
4	GRK1	2.78443285
5	ZAK	2.71477389
6	TAOK3	2.46838401
7	EIF2AK3	2.37017784
8	MST4	2.17036499
9	KDR	2.15996372
10	BCKDK	2.11634877
11	VRK2	2.07688507
12	TNIK	2.05933453
13	ADRBK2	2.00612227
14	VRK1	1.89426959
15	TLK1	1.80483013
16	NUAK1	1.79560316
17	MAP4K2	1.79348245
18	TSSK6	1.74184863
19	PLK4	1.73762147
20	MKNK1	1.69437202
21	BUB1	1.68016305
22	WNK4	1.50332690
23	TRIM28	1.49809031
24	FRK	1.47990141
25	SRPK1	1.42099218
26	TAF1	1.31164830
27	TEC	1.26896704
28	ITK	1.25307683
29	OXSR1	1.20634917
30	STK39	1.18490079
31	NEK1	1.16872165
32	ERBB3	1.16675887
33	GRK6	1.12728270
34	PINK1	1.09152531
35	BMPR1B	1.07883225
36	STK16	0.98476716
37	KIT	0.96811047
38	ACVR1B	0.96235191
39	MAP3K4	0.94703769
40	WNK3	0.94667052
41	PLK3	0.94016606
42	MAP4K1	0.93710000
43	PASK	0.93527053
44	INSRR	0.90250953
45	RPS6KA5	0.87451916
46	IKBKE	0.87341500
47	PDK2	0.83711289
48	MAP3K12	0.81109712
49	IKBKB	0.80950525
50	TIE1	0.79180856
51	CSNK1G1	0.78376509
52	EIF2AK1	0.77865614
53	BTK	0.77522181
54	NLK	0.77410127
55	MKNK2	0.76273916
56	CSNK1G3	0.74458831
57	PLK2	0.73965635
58	BMPR2	0.73518905
59	MAP2K6	0.71965987
60	MAP3K5	0.67965560
61	SYK	0.67296137
62	MAPK13	0.65134887
63	LCK	0.63631368
64	TGFBR1	0.61784648
65	DAPK1	0.61141373
66	DYRK2	0.60521656
67	EIF2AK2	0.59559524
68	PKN1	0.59256913
69	CSNK1G2	0.58042688
70	PRKCE	0.57659144
71	WEE1	0.57453734
72	SCYL2	0.55865695
73	PRKCQ	0.55771493
74	CSNK1A1L	0.54903369
75	GRK7	0.54707643
76	LYN	0.53776542
77	RPS6KA4	0.52830331
78	CDC7	0.52548276
79	ATR	0.51412116
80	PIM1	0.49270841
81	JAK3	0.48701965
82	PAK3	0.48597466
83	CSNK2A1	0.47741804
84	ADRBK1	0.45373297
85	IGF1R	0.45275517
86	CLK1	0.45163395
87	EPHA3	0.44679432
88	BCR	0.44274465
89	NME1	0.43767489
90	MAPK7	0.43719467
91	PIK3CG	0.43574684
92	FLT3	0.42087954
93	ALK	0.39990947
94	OBSCN	0.39370911
95	MATK	0.39222639
96	PLK1	0.39108784
97	AURKA	0.38632640
98	CDK19	0.38019838
99	TBK1	0.36724740
100	EPHA4	0.36594677

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.63457918
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.03277231
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.70364997
4	Protein export_Homo sapiens_hsa03060	2.58243514
5	Parkinsons disease_Homo sapiens_hsa05012	2.28761513
6	RNA polymerase_Homo sapiens_hsa03020	2.12830197
7	Ribosome_Homo sapiens_hsa03010	2.12822791
8	Sulfur metabolism_Homo sapiens_hsa00920	2.10354864
9	Asthma_Homo sapiens_hsa05310	2.07539167
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.04384579
11	Phototransduction_Homo sapiens_hsa04744	1.92722539
12	RNA degradation_Homo sapiens_hsa03018	1.89348626
13	Homologous recombination_Homo sapiens_hsa03440	1.86503986
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.81282008
15	Allograft rejection_Homo sapiens_hsa05330	1.80571345
16	Basal transcription factors_Homo sapiens_hsa03022	1.75872515
17	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.74534837
18	One carbon pool by folate_Homo sapiens_hsa00670	1.72056619
19	Antigen processing and presentation_Homo sapiens_hsa04612	1.58056581
20	Mismatch repair_Homo sapiens_hsa03430	1.57782208
21	Butanoate metabolism_Homo sapiens_hsa00650	1.56024193
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.52778724
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50867723
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.49640637
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.47808243
26	Propanoate metabolism_Homo sapiens_hsa00640	1.46908674
27	DNA replication_Homo sapiens_hsa03030	1.46301720
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.43219880
29	Huntingtons disease_Homo sapiens_hsa05016	1.41947023
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.41181355
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.39267734
32	Graft-versus-host disease_Homo sapiens_hsa05332	1.34902903
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.34685414
34	Base excision repair_Homo sapiens_hsa03410	1.34602145
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.33731421
36	Spliceosome_Homo sapiens_hsa03040	1.33666882
37	Alzheimers disease_Homo sapiens_hsa05010	1.33374323
38	RNA transport_Homo sapiens_hsa03013	1.28140401
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.28064946
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26542978
41	Peroxisome_Homo sapiens_hsa04146	1.24361288
42	Type I diabetes mellitus_Homo sapiens_hsa04940	1.23582083
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.15827163
44	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.14650134
45	Purine metabolism_Homo sapiens_hsa00230	1.13281788
46	Retinol metabolism_Homo sapiens_hsa00830	1.12170909
47	Caffeine metabolism_Homo sapiens_hsa00232	1.09086827
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.07600958
49	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.07258108
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.05636378
51	Nucleotide excision repair_Homo sapiens_hsa03420	1.02757162
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00522460
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.92954281
54	Olfactory transduction_Homo sapiens_hsa04740	0.91934742
55	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.91492550
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.91149028
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.89529060
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82708599
59	Rheumatoid arthritis_Homo sapiens_hsa05323	0.82661663
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.81630820
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80520629
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78074235
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.77198309
64	Cardiac muscle contraction_Homo sapiens_hsa04260	0.76611480
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.75950865
66	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.75828788
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.72145412
68	Taste transduction_Homo sapiens_hsa04742	0.67361776
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65197390
70	Fatty acid elongation_Homo sapiens_hsa00062	0.62087917
71	Metabolic pathways_Homo sapiens_hsa01100	0.60968043
72	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.60467268
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.59810797
74	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59211475
75	Steroid biosynthesis_Homo sapiens_hsa00100	0.56513945
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52695853
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.52539148
78	Glutathione metabolism_Homo sapiens_hsa00480	0.51552592
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.51277886
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.49438537
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.49389124
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48924298
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46369885
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46178796
85	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.45426096
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45369425
87	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.45188254
88	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.42729105
89	mRNA surveillance pathway_Homo sapiens_hsa03015	0.42572109
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41954494
91	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.40223079
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.39455752
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38628092
94	Folate biosynthesis_Homo sapiens_hsa00790	0.38021002
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37034122
96	Fatty acid degradation_Homo sapiens_hsa00071	0.36233484
97	ABC transporters_Homo sapiens_hsa02010	0.34373327
98	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.33412397
99	Morphine addiction_Homo sapiens_hsa05032	0.29624486
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29210500

HNRNPA1P50

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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