HNRNPA1P51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.46511546
2proteasome assembly (GO:0043248)5.38570473
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.35890628
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.19131901
5regulation of isotype switching to IgG isotypes (GO:0048302)4.82442769
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.56280009
7cytidine metabolic process (GO:0046087)4.50314484
8cytidine catabolic process (GO:0006216)4.50314484
9cytidine deamination (GO:0009972)4.50314484
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.43993523
11positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.41191921
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.27539973
13ATP synthesis coupled proton transport (GO:0015986)4.27539973
14regulation of cellular amino acid metabolic process (GO:0006521)4.24642647
15nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.20599827
16positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.07891996
17exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.06459783
18rRNA modification (GO:0000154)4.05723288
19negative regulation of ligase activity (GO:0051352)4.03470139
20negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.03470139
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.97758445
22protein neddylation (GO:0045116)3.97510327
23signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.97150229
24signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.97150229
25signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.97150229
26regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.95829855
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.92691294
28intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.88134782
29signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.88134782
30rRNA methylation (GO:0031167)3.84001248
31regulation of immunoglobulin secretion (GO:0051023)3.81976425
32signal transduction involved in DNA integrity checkpoint (GO:0072401)3.78327472
33signal transduction involved in DNA damage checkpoint (GO:0072422)3.78327472
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.75197552
35termination of RNA polymerase III transcription (GO:0006386)3.75197552
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.74935716
37RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.72865551
38pyrimidine ribonucleoside catabolic process (GO:0046133)3.72313597
39DNA catabolic process, exonucleolytic (GO:0000738)3.68117359
40ribosome assembly (GO:0042255)3.61313551
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.61026720
42water-soluble vitamin biosynthetic process (GO:0042364)3.54138870
43regulation of podosome assembly (GO:0071801)3.52670683
44platelet dense granule organization (GO:0060155)3.48908551
45ribosomal small subunit assembly (GO:0000028)3.45476131
46cullin deneddylation (GO:0010388)3.43828627
47positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.42605725
48DNA double-strand break processing (GO:0000729)3.36444598
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.36236915
50NADH dehydrogenase complex assembly (GO:0010257)3.36236915
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36236915
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34770158
53positive regulation of isotype switching (GO:0045830)3.34522674
54intracellular protein transmembrane import (GO:0044743)3.34243272
55L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.34082638
56respiratory chain complex IV assembly (GO:0008535)3.30761002
57positive regulation of ligase activity (GO:0051351)3.29544262
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.24078171
59protein complex biogenesis (GO:0070271)3.22501713
60chaperone-mediated protein transport (GO:0072321)3.18882828
61regulation of regulatory T cell differentiation (GO:0045589)3.13553704
62mitochondrial respiratory chain complex assembly (GO:0033108)3.10666536
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09963648
64tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09963648
65signal peptide processing (GO:0006465)3.09184835
66positive regulation of DNA recombination (GO:0045911)3.03653523
67protein deneddylation (GO:0000338)3.02405792
68regulation of cellular amine metabolic process (GO:0033238)3.01915011
69base-excision repair, AP site formation (GO:0006285)3.01581766
70negative regulation of protein ubiquitination (GO:0031397)3.00368238
71positive regulation of cell cycle arrest (GO:0071158)3.00217499
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.98329969
73DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.97275480
74respiratory electron transport chain (GO:0022904)2.93186321
75regulation of ubiquitin-protein transferase activity (GO:0051438)2.93146218
76electron transport chain (GO:0022900)2.89558147
77spliceosomal snRNP assembly (GO:0000387)2.88323681
78peptidyl-histidine modification (GO:0018202)2.85718367
79regulation of chronic inflammatory response (GO:0002676)2.85323686
80regulation of ligase activity (GO:0051340)2.84349063
81histone H2A acetylation (GO:0043968)2.81352800
82pseudouridine synthesis (GO:0001522)2.77664865
83negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.75672591
84L-methionine salvage (GO:0071267)2.74886371
85L-methionine biosynthetic process (GO:0071265)2.74886371
86amino acid salvage (GO:0043102)2.74886371
87DNA damage response, detection of DNA damage (GO:0042769)2.71492731
88rRNA processing (GO:0006364)2.69121049
89deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.65333855
90transcription elongation from RNA polymerase I promoter (GO:0006362)2.65153448
91cytochrome complex assembly (GO:0017004)2.65149202
92protein targeting to mitochondrion (GO:0006626)2.64950000
93rRNA metabolic process (GO:0016072)2.63397953
94amino acid activation (GO:0043038)2.61766801
95tRNA aminoacylation (GO:0043039)2.61766801
96termination of RNA polymerase I transcription (GO:0006363)2.59154621
97regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.58639518
98positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.58639518
99protein localization to mitochondrion (GO:0070585)2.53789973
100positive regulation of immunoglobulin production (GO:0002639)2.52238071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.00377273
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.30836097
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.98960559
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.57536482
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.13124854
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01130367
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97919187
8VDR_22108803_ChIP-Seq_LS180_Human2.82911447
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73878747
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.71144194
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67115789
12VDR_23849224_ChIP-Seq_CD4+_Human2.63828076
13ELK1_19687146_ChIP-ChIP_HELA_Human2.55444186
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55097572
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54664579
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53982536
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.49470224
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.43060335
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.36626692
20FOXP3_21729870_ChIP-Seq_TREG_Human2.29760086
21E2F7_22180533_ChIP-Seq_HELA_Human2.23444800
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12310975
23EWS_26573619_Chip-Seq_HEK293_Human2.10763905
24TAF15_26573619_Chip-Seq_HEK293_Human2.09945963
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.00772531
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92328766
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91259092
28ZNF274_21170338_ChIP-Seq_K562_Hela1.89291196
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84705990
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82052592
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80755494
32MYC_18940864_ChIP-ChIP_HL60_Human1.71305529
33FUS_26573619_Chip-Seq_HEK293_Human1.68069090
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66258524
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.63785024
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59904631
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56510534
38TTF2_22483619_ChIP-Seq_HELA_Human1.55373157
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51454622
40DCP1A_22483619_ChIP-Seq_HELA_Human1.50208151
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48018336
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46668211
43P300_19829295_ChIP-Seq_ESCs_Human1.44209109
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38119160
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37656390
46NANOG_19829295_ChIP-Seq_ESCs_Human1.26758064
47SOX2_19829295_ChIP-Seq_ESCs_Human1.26758064
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26687919
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26420431
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26183912
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23871507
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23799977
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22720018
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19465332
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17888557
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17632004
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17579771
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17531641
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17204158
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.16547193
61IGF1R_20145208_ChIP-Seq_DFB_Human1.15782325
62GABP_19822575_ChIP-Seq_HepG2_Human1.15687453
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15674647
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.14729823
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14039243
66TP53_22573176_ChIP-Seq_HFKS_Human1.12700537
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12158613
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.10906167
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.10558503
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08622911
71IRF1_19129219_ChIP-ChIP_H3396_Human1.07109728
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06270889
73ER_23166858_ChIP-Seq_MCF-7_Human1.05763077
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03004730
75GATA3_26560356_Chip-Seq_TH2_Human1.02949410
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02290188
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99968460
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99822522
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99181552
80CBP_20019798_ChIP-Seq_JUKART_Human0.99181552
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97600396
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96953100
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.96953100
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96180578
85CRX_20693478_ChIP-Seq_RETINA_Mouse0.95980912
86AR_20517297_ChIP-Seq_VCAP_Human0.95296643
87IRF8_21731497_ChIP-ChIP_J774_Mouse0.94589096
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94010404
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92939939
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92341018
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92195451
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89939392
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.89453068
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87602238
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.86257847
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85438916
97XRN2_22483619_ChIP-Seq_HELA_Human0.85215233
98NCOR_22424771_ChIP-Seq_293T_Human0.84707071
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84350170
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83994442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.52098762
2MP0001835_abnormal_antigen_presentation4.19722503
3MP0005671_abnormal_response_to3.38508218
4MP0001873_stomach_inflammation3.33405174
5MP0005084_abnormal_gallbladder_morpholo2.72941821
6MP0006292_abnormal_olfactory_placode2.54034577
7MP0002102_abnormal_ear_morphology2.44869688
8MP0008058_abnormal_DNA_repair2.26246878
9MP0006072_abnormal_retinal_apoptosis2.19187406
10MP0003786_premature_aging2.17050177
11MP0009785_altered_susceptibility_to2.12285593
12MP0004957_abnormal_blastocyst_morpholog2.03678658
13MP0003195_calcinosis2.01642234
14MP0004145_abnormal_muscle_electrophysio1.92673436
15MP0010094_abnormal_chromosome_stability1.87779098
16MP0003567_abnormal_fetal_cardiomyocyte1.87012571
17MP0003693_abnormal_embryo_hatching1.84060048
18MP0006036_abnormal_mitochondrial_physio1.74966788
19MP0005551_abnormal_eye_electrophysiolog1.73906030
20MP0002148_abnormal_hypersensitivity_rea1.71699898
21MP0008872_abnormal_physiological_respon1.71143040
22MP0002234_abnormal_pharynx_morphology1.69568026
23MP0008875_abnormal_xenobiotic_pharmacok1.68475267
24MP0002277_abnormal_respiratory_mucosa1.65075526
25MP0005377_hearing/vestibular/ear_phenot1.64138329
26MP0003878_abnormal_ear_physiology1.64138329
27MP0003718_maternal_effect1.62077787
28MP0001293_anophthalmia1.61885865
29MP0006035_abnormal_mitochondrial_morpho1.60071394
30MP0002138_abnormal_hepatobiliary_system1.58646556
31MP0009697_abnormal_copulation1.57066644
32MP0004142_abnormal_muscle_tone1.57020566
33MP0002736_abnormal_nociception_after1.54957928
34MP0005310_abnormal_salivary_gland1.54945198
35MP0003283_abnormal_digestive_organ1.49821168
36MP0003186_abnormal_redox_activity1.47761227
37MP0005387_immune_system_phenotype1.46910661
38MP0001790_abnormal_immune_system1.46910661
39MP0004147_increased_porphyrin_level1.38929539
40MP0001485_abnormal_pinna_reflex1.38336277
41MP0005451_abnormal_body_composition1.34144063
42MP0001853_heart_inflammation1.32321244
43MP0002166_altered_tumor_susceptibility1.30105114
44MP0002653_abnormal_ependyma_morphology1.29345246
45MP0003880_abnormal_central_pattern1.27130826
46MP0000631_abnormal_neuroendocrine_gland1.23692384
47MP0004742_abnormal_vestibular_system1.23197771
48MP0002006_tumorigenesis1.21481557
49MP0008877_abnormal_DNA_methylation1.17879378
50MP0008995_early_reproductive_senescence1.14104292
51MP0005253_abnormal_eye_physiology1.09741021
52MP0001968_abnormal_touch/_nociception1.07861932
53MP0010386_abnormal_urinary_bladder1.07563015
54MP0008789_abnormal_olfactory_epithelium1.04032369
55MP0001800_abnormal_humoral_immune1.02734656
56MP0002938_white_spotting1.01628798
57MP0001663_abnormal_digestive_system0.99731797
58MP0003137_abnormal_impulse_conducting0.97553160
59MP0002405_respiratory_system_inflammati0.96142631
60MP0003136_yellow_coat_color0.96039138
61MP0000383_abnormal_hair_follicle0.95137779
62MP0009765_abnormal_xenobiotic_induced0.91806566
63MP0005645_abnormal_hypothalamus_physiol0.91316675
64MP0000427_abnormal_hair_cycle0.89272318
65MP0005646_abnormal_pituitary_gland0.88814937
66MP0001905_abnormal_dopamine_level0.88164118
67MP0005000_abnormal_immune_tolerance0.88127862
68MP0003866_abnormal_defecation0.87145963
69MP0004215_abnormal_myocardial_fiber0.86322478
70MP0003111_abnormal_nucleus_morphology0.85634200
71MP0005395_other_phenotype0.85005736
72MP0000685_abnormal_immune_system0.84120569
73MP0002733_abnormal_thermal_nociception0.83996442
74MP0009333_abnormal_splenocyte_physiolog0.79944586
75MP0002751_abnormal_autonomic_nervous0.79783851
76MP0002282_abnormal_trachea_morphology0.79482227
77MP0006276_abnormal_autonomic_nervous0.75232221
78MP0001764_abnormal_homeostasis0.74365408
79MP0009745_abnormal_behavioral_response0.72099423
80MP0003119_abnormal_digestive_system0.71684441
81MP0006082_CNS_inflammation0.71644450
82MP0005195_abnormal_posterior_eye0.70453766
83MP0000358_abnormal_cell_content/0.68776821
84MP0005381_digestive/alimentary_phenotyp0.68644766
85MP0001929_abnormal_gametogenesis0.68313039
86MP0002420_abnormal_adaptive_immunity0.68037121
87MP0008007_abnormal_cellular_replicative0.67699332
88MP0001819_abnormal_immune_cell0.67597046
89MP0002272_abnormal_nervous_system0.66962546
90MP0002723_abnormal_immune_serum0.66413361
91MP0010307_abnormal_tumor_latency0.66286117
92MP0010155_abnormal_intestine_physiology0.66123188
93MP0002210_abnormal_sex_determination0.64397297
94MP0000467_abnormal_esophagus_morphology0.64291711
95MP0003938_abnormal_ear_development0.64119236
96MP0001286_abnormal_eye_development0.63165609
97MP0003937_abnormal_limbs/digits/tail_de0.63042055
98MP0001986_abnormal_taste_sensitivity0.62571291
99MP0004133_heterotaxia0.62556930
100MP0001970_abnormal_pain_threshold0.62308200

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.66802228
2Acute necrotizing encephalopathy (HP:0006965)3.93955096
3Increased hepatocellular lipid droplets (HP:0006565)3.77333349
4Mitochondrial inheritance (HP:0001427)3.63910406
5Abnormality of midbrain morphology (HP:0002418)3.58149398
6Molar tooth sign on MRI (HP:0002419)3.58149398
7Stomatitis (HP:0010280)3.57291834
8Acute encephalopathy (HP:0006846)3.53888816
9Increased CSF lactate (HP:0002490)3.44568245
10Colon cancer (HP:0003003)3.41228162
11Hepatocellular necrosis (HP:0001404)3.31364290
12Pancreatic cysts (HP:0001737)3.27468942
13Lipid accumulation in hepatocytes (HP:0006561)3.26607497
143-Methylglutaconic aciduria (HP:0003535)3.23861700
15True hermaphroditism (HP:0010459)3.21532212
16Abnormal mitochondria in muscle tissue (HP:0008316)3.21293251
17Increased IgM level (HP:0003496)3.19951478
18IgG deficiency (HP:0004315)3.17230797
19Progressive macrocephaly (HP:0004481)3.14401254
20Abnormality of alanine metabolism (HP:0010916)3.14076068
21Hyperalaninemia (HP:0003348)3.14076068
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.14076068
23Methylmalonic acidemia (HP:0002912)2.98927831
24Hepatic necrosis (HP:0002605)2.95400764
25Pancreatic fibrosis (HP:0100732)2.88638838
26Pancytopenia (HP:0001876)2.81540995
27Increased serum lactate (HP:0002151)2.79684077
28Optic disc pallor (HP:0000543)2.78786789
29Renal Fanconi syndrome (HP:0001994)2.75549053
30Cerebral edema (HP:0002181)2.70663195
31Microvesicular hepatic steatosis (HP:0001414)2.69001243
32Abnormality of the labia minora (HP:0012880)2.58979187
33Nephronophthisis (HP:0000090)2.53985993
34Hypoproteinemia (HP:0003075)2.52623334
35Type I transferrin isoform profile (HP:0003642)2.52110596
36Abnormality of serum amino acid levels (HP:0003112)2.49218439
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49142581
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.42956719
39Abolished electroretinogram (ERG) (HP:0000550)2.42835491
40Exertional dyspnea (HP:0002875)2.40934095
41Increased serum pyruvate (HP:0003542)2.37230847
42Lactic acidosis (HP:0003128)2.33788256
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31801430
44Leukodystrophy (HP:0002415)2.24255470
45Lethargy (HP:0001254)2.22824399
46Methylmalonic aciduria (HP:0012120)2.22004970
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19108458
48Aplasia/hypoplasia of the uterus (HP:0008684)2.17270083
49Congenital, generalized hypertrichosis (HP:0004540)2.17007420
50Attenuation of retinal blood vessels (HP:0007843)2.10404052
51Abnormality of methionine metabolism (HP:0010901)2.10403214
52Congenital stationary night blindness (HP:0007642)2.10052747
53Pendular nystagmus (HP:0012043)2.09259855
54Renal cortical cysts (HP:0000803)2.08542234
55Large for gestational age (HP:0001520)2.07715650
56Respiratory failure (HP:0002878)2.05772919
57Severe combined immunodeficiency (HP:0004430)2.03806126
58B lymphocytopenia (HP:0010976)2.03748596
59Abnormality of the ileum (HP:0001549)2.01690264
60Abnormality of B cell number (HP:0010975)1.98130604
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97473501
62Bile duct proliferation (HP:0001408)1.97039919
63Abnormal biliary tract physiology (HP:0012439)1.97039919
64Hyperglycinemia (HP:0002154)1.96653552
65Sclerocornea (HP:0000647)1.95866211
66Hyperglycinuria (HP:0003108)1.94958730
67Respiratory difficulties (HP:0002880)1.94497739
68Panhypogammaglobulinemia (HP:0003139)1.94123088
69Constricted visual fields (HP:0001133)1.92829809
70Meckel diverticulum (HP:0002245)1.92471439
71Hypoplasia of the uterus (HP:0000013)1.89055245
72Oral leukoplakia (HP:0002745)1.88787388
73Abnormality of the prostate (HP:0008775)1.86185117
74Homocystinuria (HP:0002156)1.86057347
75Abnormality of homocysteine metabolism (HP:0010919)1.86057347
76Elevated erythrocyte sedimentation rate (HP:0003565)1.85693190
77Abnormal rod and cone electroretinograms (HP:0008323)1.84441822
78Abnormality of glycolysis (HP:0004366)1.83058075
79Abnormality of the vitamin B12 metabolism (HP:0004341)1.82728883
80Cerebral hypomyelination (HP:0006808)1.82630029
81Exercise intolerance (HP:0003546)1.82409542
82Type 2 muscle fiber atrophy (HP:0003554)1.81686310
83Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81558443
84Abnormality of the renal medulla (HP:0100957)1.78460099
85Carpal bone hypoplasia (HP:0001498)1.76897269
86Abnormality of macular pigmentation (HP:0008002)1.76649740
87Abnormality of renal resorption (HP:0011038)1.76645671
88Increased intramyocellular lipid droplets (HP:0012240)1.76286816
89Cellular immunodeficiency (HP:0005374)1.76240085
90Increased corneal curvature (HP:0100692)1.74037182
91Keratoconus (HP:0000563)1.74037182
92Abnormal glycosylation (HP:0012345)1.73916351
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73916351
94Abnormal protein N-linked glycosylation (HP:0012347)1.73916351
95Abnormal protein glycosylation (HP:0012346)1.73916351
96Progressive inability to walk (HP:0002505)1.73787341
97CNS demyelination (HP:0007305)1.73261727
98Abnormality of the renal collecting system (HP:0004742)1.70465577
99Megaloblastic anemia (HP:0001889)1.70041595
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.70021187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.62520645
2MST43.93102238
3MAP4K23.40896530
4VRK23.36378384
5EIF2AK32.90576863
6EIF2AK12.74515571
7TSSK62.67851000
8NUAK12.67687993
9NME12.54626443
10TLK12.53170202
11BUB12.50734709
12PBK2.31209302
13MKNK12.19310376
14VRK12.15525035
15TRIM282.07309335
16WNK31.98420961
17TXK1.93022030
18TNIK1.87015694
19BMPR1B1.81677566
20ADRBK21.78939043
21TAF11.74426756
22BCKDK1.72555054
23PLK31.72117821
24TEC1.65927170
25PLK41.61651757
26MAP3K121.48200885
27SRPK11.34492211
28MKNK21.25110994
29GRK11.22033766
30PASK1.20514948
31KDR1.13486665
32NEK11.12004538
33ITK1.06431684
34PDK21.06364367
35RPS6KA41.04758953
36EIF2AK20.98922286
37DYRK20.95930518
38OXSR10.95026535
39STK38L0.93175539
40PLK10.93033899
41MYLK0.90937230
42ERBB30.89066058
43STK390.88641764
44PIK3CG0.86081294
45CDK80.84338609
46DAPK10.83474832
47CDC70.81071853
48TTK0.75726064
49INSRR0.75472409
50TGFBR10.75340774
51MAPKAPK50.72846594
52WNK40.70898214
53ATR0.69895193
54IKBKB0.66557491
55PLK20.62464259
56PKN10.59485095
57TIE10.57891277
58MAPK130.54817405
59PRKCE0.54759348
60AURKB0.53958972
61STK160.53478789
62PAK40.53154795
63RPS6KA50.52494395
64STK40.49602388
65MAP2K60.48982327
66PINK10.47689403
67NME20.44957177
68EPHA30.44295889
69CHEK20.43418015
70CSNK2A10.41464914
71WEE10.39879783
72FLT30.39228135
73LIMK10.39093261
74PRKCQ0.38946295
75FRK0.38678483
76ALK0.37795721
77STK30.36192707
78MAP2K70.35074092
79CSNK2A20.34369023
80IGF1R0.32272346
81SYK0.31975023
82BTK0.29061051
83TAOK30.28971329
84CSF1R0.28824114
85PRKCG0.28263006
86GRK50.27483899
87CSNK1G10.27093732
88ATM0.25860278
89AURKA0.25373842
90BCR0.24922891
91LYN0.24720508
92CSNK1A10.23249434
93OBSCN0.22585741
94DYRK30.22474382
95LCK0.22383176
96ROCK10.22021504
97PIM10.21506464
98CSNK1G30.21421907
99DAPK30.21030542
100PHKG20.19551573

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.44821533
2Protein export_Homo sapiens_hsa030603.38966699
3Oxidative phosphorylation_Homo sapiens_hsa001902.84456390
4RNA polymerase_Homo sapiens_hsa030202.82372276
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69570154
6Asthma_Homo sapiens_hsa053102.53364309
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48880790
8Parkinsons disease_Homo sapiens_hsa050122.42617421
9Allograft rejection_Homo sapiens_hsa053302.34673606
10Ribosome_Homo sapiens_hsa030102.17460958
11Primary immunodeficiency_Homo sapiens_hsa053402.09068557
12Autoimmune thyroid disease_Homo sapiens_hsa053202.05828085
13Propanoate metabolism_Homo sapiens_hsa006401.98189700
14Basal transcription factors_Homo sapiens_hsa030221.92140461
15RNA degradation_Homo sapiens_hsa030181.88438473
16DNA replication_Homo sapiens_hsa030301.80873745
17Non-homologous end-joining_Homo sapiens_hsa034501.78413931
18Homologous recombination_Homo sapiens_hsa034401.76729534
19Mismatch repair_Homo sapiens_hsa034301.75847130
20Graft-versus-host disease_Homo sapiens_hsa053321.73746722
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.71990282
22Fanconi anemia pathway_Homo sapiens_hsa034601.66714278
23One carbon pool by folate_Homo sapiens_hsa006701.64253852
24Base excision repair_Homo sapiens_hsa034101.62821215
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58044036
26Huntingtons disease_Homo sapiens_hsa050161.55347417
27RNA transport_Homo sapiens_hsa030131.51795584
28Spliceosome_Homo sapiens_hsa030401.46830678
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45497303
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44327004
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34772000
32Type I diabetes mellitus_Homo sapiens_hsa049401.33383805
33Pyrimidine metabolism_Homo sapiens_hsa002401.32671857
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.29287219
35Alzheimers disease_Homo sapiens_hsa050101.28979355
36Nucleotide excision repair_Homo sapiens_hsa034201.26864529
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23019541
38Regulation of autophagy_Homo sapiens_hsa041401.22286222
39Butanoate metabolism_Homo sapiens_hsa006501.19284381
40Antigen processing and presentation_Homo sapiens_hsa046121.17003282
41Purine metabolism_Homo sapiens_hsa002301.14648121
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09761039
43Linoleic acid metabolism_Homo sapiens_hsa005911.09388601
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00605295
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97925418
46Phototransduction_Homo sapiens_hsa047440.96371459
47Peroxisome_Homo sapiens_hsa041460.92181797
48Steroid biosynthesis_Homo sapiens_hsa001000.91671328
49Hematopoietic cell lineage_Homo sapiens_hsa046400.91662031
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90449484
51Rheumatoid arthritis_Homo sapiens_hsa053230.87170719
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86153367
53Folate biosynthesis_Homo sapiens_hsa007900.82569837
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75730782
55Selenocompound metabolism_Homo sapiens_hsa004500.71927038
56T cell receptor signaling pathway_Homo sapiens_hsa046600.71286301
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71081207
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.70902191
59Pyruvate metabolism_Homo sapiens_hsa006200.68659445
60Cardiac muscle contraction_Homo sapiens_hsa042600.68329269
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68019654
62Caffeine metabolism_Homo sapiens_hsa002320.67694826
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67599917
64Ether lipid metabolism_Homo sapiens_hsa005650.66873902
65Sulfur metabolism_Homo sapiens_hsa009200.64396324
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63224363
67Collecting duct acid secretion_Homo sapiens_hsa049660.59256286
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59126624
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58928324
70Glutathione metabolism_Homo sapiens_hsa004800.58111593
71Metabolic pathways_Homo sapiens_hsa011000.56049107
72Tryptophan metabolism_Homo sapiens_hsa003800.55506453
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55274696
74Olfactory transduction_Homo sapiens_hsa047400.52157603
75Epstein-Barr virus infection_Homo sapiens_hsa051690.49373437
76Fat digestion and absorption_Homo sapiens_hsa049750.48568593
77Arachidonic acid metabolism_Homo sapiens_hsa005900.47290263
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47118682
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.43824233
80Nitrogen metabolism_Homo sapiens_hsa009100.43268676
81Carbon metabolism_Homo sapiens_hsa012000.43105853
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42446877
83Biosynthesis of amino acids_Homo sapiens_hsa012300.38824933
84Fatty acid elongation_Homo sapiens_hsa000620.38573444
85Cell cycle_Homo sapiens_hsa041100.38030262
86mRNA surveillance pathway_Homo sapiens_hsa030150.36871761
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.36497787
88Fatty acid degradation_Homo sapiens_hsa000710.36214783
89Chemical carcinogenesis_Homo sapiens_hsa052040.35439488
90Measles_Homo sapiens_hsa051620.34769792
91Retinol metabolism_Homo sapiens_hsa008300.32888754
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30845078
93Systemic lupus erythematosus_Homo sapiens_hsa053220.30462567
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29567126
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.29306491
96Vitamin B6 metabolism_Homo sapiens_hsa007500.29005914
97beta-Alanine metabolism_Homo sapiens_hsa004100.26062598
98Taste transduction_Homo sapiens_hsa047420.26055097
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23629899
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.23149825

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