ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	5.06089230
2	protein neddylation (GO:0045116)	4.82313282
3	DNA deamination (GO:0045006)	4.66150067
4	GTP biosynthetic process (GO:0006183)	4.39386297
5	ATP synthesis coupled proton transport (GO:0015986)	4.36185716
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.36185716
7	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	4.14498635
8	regulation of mitotic spindle checkpoint (GO:1903504)	4.14498635
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.98851276
10	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.97883342
11	cullin deneddylation (GO:0010388)	3.95210040
12	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.83551896
13	UTP biosynthetic process (GO:0006228)	3.82708854
14	protein deneddylation (GO:0000338)	3.80814430
15	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.78385144
16	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.78385144
17	UTP metabolic process (GO:0046051)	3.65350414
18	proteasome assembly (GO:0043248)	3.63485547
19	chaperone-mediated protein transport (GO:0072321)	3.63300513
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.59321564
21	NADH dehydrogenase complex assembly (GO:0010257)	3.59321564
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.59321564
23	DNA replication-dependent nucleosome organization (GO:0034723)	3.58937693
24	DNA replication-dependent nucleosome assembly (GO:0006335)	3.58937693
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.54416950
26	spliceosomal snRNP assembly (GO:0000387)	3.40731129
27	maturation of 5.8S rRNA (GO:0000460)	3.39509265
28	DNA damage response, detection of DNA damage (GO:0042769)	3.38881905
29	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.31576089
30	histone mRNA metabolic process (GO:0008334)	3.31525836
31	pseudouridine synthesis (GO:0001522)	3.30780116
32	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.21734031
33	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.17409684
34	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.16642699
35	purine nucleobase biosynthetic process (GO:0009113)	3.11156968
36	nucleobase biosynthetic process (GO:0046112)	3.10541778
37	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.07172886
38	DNA double-strand break processing (GO:0000729)	3.06337410
39	rRNA modification (GO:0000154)	3.06107789
40	guanosine-containing compound biosynthetic process (GO:1901070)	3.05908705
41	regulation of helicase activity (GO:0051095)	3.05464167
42	chromatin remodeling at centromere (GO:0031055)	3.04595542
43	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.02100304
44	CTP metabolic process (GO:0046036)	3.02049288
45	CTP biosynthetic process (GO:0006241)	3.02049288
46	IMP biosynthetic process (GO:0006188)	2.98032455
47	protein complex biogenesis (GO:0070271)	2.97815433
48	CENP-A containing nucleosome assembly (GO:0034080)	2.96091018
49	spliceosomal complex assembly (GO:0000245)	2.93772444
50	peptidyl-histidine modification (GO:0018202)	2.93078373
51	ribosomal small subunit assembly (GO:0000028)	2.92661276
52	DNA replication checkpoint (GO:0000076)	2.88982294
53	mitochondrial respiratory chain complex assembly (GO:0033108)	2.88449546
54	IMP metabolic process (GO:0046040)	2.85235821
55	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.81883032
56	7-methylguanosine mRNA capping (GO:0006370)	2.81610253
57	tRNA processing (GO:0008033)	2.80640798
58	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.77006269
59	attachment of spindle microtubules to kinetochore (GO:0008608)	2.76633465
60	7-methylguanosine RNA capping (GO:0009452)	2.75083879
61	RNA capping (GO:0036260)	2.75083879
62	electron transport chain (GO:0022900)	2.74908722
63	nucleoside diphosphate phosphorylation (GO:0006165)	2.74427736
64	respiratory electron transport chain (GO:0022904)	2.74110752
65	maturation of SSU-rRNA (GO:0030490)	2.70427198
66	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	2.69483734
67	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	2.69483734
68	ribosome assembly (GO:0042255)	2.69168589
69	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.68745413
70	neural tube formation (GO:0001841)	2.68223842
71	sequestering of actin monomers (GO:0042989)	2.67189745
72	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.66333419
73	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.64949360
74	protein localization to kinetochore (GO:0034501)	2.64621992
75	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.61960662
76	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.61953059
77	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.60064517
78	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.60064517
79	DNA catabolic process, exonucleolytic (GO:0000738)	2.59368945
80	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.59300759
81	ATP biosynthetic process (GO:0006754)	2.58746833
82	mitochondrial RNA metabolic process (GO:0000959)	2.56832522
83	urate metabolic process (GO:0046415)	2.56582938
84	adenosine metabolic process (GO:0046085)	2.56254041
85	regulation of cellular amino acid metabolic process (GO:0006521)	2.56045222
86	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.55427908
87	tRNA metabolic process (GO:0006399)	2.55013360
88	ncRNA catabolic process (GO:0034661)	2.53226542
89	recombinational repair (GO:0000725)	2.52691526
90	histone exchange (GO:0043486)	2.52156081
91	rRNA processing (GO:0006364)	2.51075215
92	nucleoside triphosphate biosynthetic process (GO:0009142)	2.50490300
93	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.49610721
94	termination of RNA polymerase III transcription (GO:0006386)	2.49610721
95	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.48125763
96	double-strand break repair via homologous recombination (GO:0000724)	2.47118023
97	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.46548390
98	rRNA metabolic process (GO:0016072)	2.45975034
99	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.45521063
100	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.44229807

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.66515357
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.43340941
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.55829964
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.30790900
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.16706725
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.01967232
7	VDR_23849224_ChIP-Seq_CD4+_Human	2.80761281
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.78681244
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.76669725
10	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.68479620
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.58731310
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.53524179
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.48803106
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.44808532
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.44519741
16	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.41817406
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.36729972
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.33257341
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.25445368
20	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.19328817
21	E2F7_22180533_ChIP-Seq_HELA_Human	2.18995325
22	EWS_26573619_Chip-Seq_HEK293_Human	2.08891296
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.03512744
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.01947490
25	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.93376390
26	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.91552617
27	VDR_22108803_ChIP-Seq_LS180_Human	1.88232849
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.86659224
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82503194
30	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.79829247
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.76393614
32	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.70783117
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.69692795
34	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.65813073
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.63689211
36	DCP1A_22483619_ChIP-Seq_HELA_Human	1.62588460
37	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.61812592
38	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.58304840
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.56593919
40	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.55069961
41	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.49048520
42	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.45574159
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.45521651
44	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.44394986
45	FUS_26573619_Chip-Seq_HEK293_Human	1.44249233
46	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.42613854
47	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.42104190
48	P300_19829295_ChIP-Seq_ESCs_Human	1.39774285
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38580667
50	IGF1R_20145208_ChIP-Seq_DFB_Human	1.35989986
51	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.35935898
52	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.35311620
53	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.32690402
54	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31377796
55	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.30431206
56	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30205914
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27628916
58	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.27467841
59	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.27255727
60	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.26952942
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25027815
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24335053
63	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.19650483
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18929423
65	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.18106745
66	ER_23166858_ChIP-Seq_MCF-7_Human	1.16595108
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.16152510
68	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.15871180
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.15627761
70	XRN2_22483619_ChIP-Seq_HELA_Human	1.14960613
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13476117
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13295559
73	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.12105754
74	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.09871016
75	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.08952431
76	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.08868499
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08489584
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08489584
79	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.08378666
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08206214
81	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.06305960
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02503586
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02503586
84	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.01651649
85	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.01226304
86	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.99861236
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99460343
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98961448
89	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.97860679
90	GATA3_26560356_Chip-Seq_TH2_Human	0.96257692
91	AR_20517297_ChIP-Seq_VCAP_Human	0.95839081
92	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.95732831
93	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.93529786
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91811221
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.91058418
96	CBP_20019798_ChIP-Seq_JUKART_Human	0.91058418
97	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.90656570
98	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.90357192
99	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.89605940
100	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.89552774

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.51594794
2	MP0006072_abnormal_retinal_apoptosis	3.08295379
3	MP0006292_abnormal_olfactory_placode	2.58220274
4	MP0003693_abnormal_embryo_hatching	2.54818355
5	MP0003786_premature_aging	2.52260283
6	MP0005084_abnormal_gallbladder_morpholo	2.51706304
7	MP0001529_abnormal_vocalization	2.49396965
8	MP0005646_abnormal_pituitary_gland	2.47265794
9	MP0008058_abnormal_DNA_repair	2.38343670
10	MP0008995_early_reproductive_senescence	2.30461735
11	MP0003787_abnormal_imprinting	2.26177679
12	MP0010094_abnormal_chromosome_stability	2.24933647
13	MP0003646_muscle_fatigue	2.16386710
14	MP0003195_calcinosis	2.06062977
15	MP0006035_abnormal_mitochondrial_morpho	2.05434454
16	MP0002736_abnormal_nociception_after	2.02072065
17	MP0004957_abnormal_blastocyst_morpholog	1.98841336
18	MP0002102_abnormal_ear_morphology	1.97639179
19	MP0008875_abnormal_xenobiotic_pharmacok	1.88784865
20	MP0005253_abnormal_eye_physiology	1.79679695
21	MP0002234_abnormal_pharynx_morphology	1.68518619
22	MP0002277_abnormal_respiratory_mucosa	1.67431883
23	MP0008872_abnormal_physiological_respon	1.62129215
24	MP0001293_anophthalmia	1.60018527
25	MP0005551_abnormal_eye_electrophysiolog	1.55768202
26	MP0002090_abnormal_vision	1.54020111
27	MP0005645_abnormal_hypothalamus_physiol	1.53710436
28	MP0003122_maternal_imprinting	1.48649291
29	MP0001919_abnormal_reproductive_system	1.47995429
30	MP0000372_irregular_coat_pigmentation	1.45663481
31	MP0006276_abnormal_autonomic_nervous	1.45144716
32	MP0005671_abnormal_response_to	1.43131013
33	MP0003121_genomic_imprinting	1.39933167
34	MP0003567_abnormal_fetal_cardiomyocyte	1.37184606
35	MP0003111_abnormal_nucleus_morphology	1.34545943
36	MP0003077_abnormal_cell_cycle	1.32474307
37	MP0000631_abnormal_neuroendocrine_gland	1.28912712
38	MP0002822_catalepsy	1.28588377
39	MP0006036_abnormal_mitochondrial_physio	1.27645394
40	MP0009764_decreased_sensitivity_to	1.25751554
41	MP0008932_abnormal_embryonic_tissue	1.24804872
42	MP0002638_abnormal_pupillary_reflex	1.23445134
43	MP0001968_abnormal_touch/_nociception	1.23167607
44	MP0000537_abnormal_urethra_morphology	1.22130039
45	MP0008007_abnormal_cellular_replicative	1.19751879
46	MP0002653_abnormal_ependyma_morphology	1.17382028
47	MP0003718_maternal_effect	1.15116136
48	MP0009785_altered_susceptibility_to	1.14900040
49	MP0005389_reproductive_system_phenotype	1.13081646
50	MP0003806_abnormal_nucleotide_metabolis	1.12986336
51	MP0003724_increased_susceptibility_to	1.12247823
52	MP0000049_abnormal_middle_ear	1.11351220
53	MP0001835_abnormal_antigen_presentation	1.09381053
54	MP0008789_abnormal_olfactory_epithelium	1.07623483
55	MP0005187_abnormal_penis_morphology	1.06469291
56	MP0003186_abnormal_redox_activity	1.06061767
57	MP0002163_abnormal_gland_morphology	1.06024990
58	MP0002138_abnormal_hepatobiliary_system	1.04837933
59	MP0001800_abnormal_humoral_immune	1.03556309
60	MP0003011_delayed_dark_adaptation	1.03365773
61	MP0003878_abnormal_ear_physiology	1.02667215
62	MP0005377_hearing/vestibular/ear_phenot	1.02667215
63	MP0005085_abnormal_gallbladder_physiolo	1.01630930
64	MP0000647_abnormal_sebaceous_gland	0.98678307
65	MP0003119_abnormal_digestive_system	0.97521675
66	MP0001764_abnormal_homeostasis	0.97075200
67	MP0003937_abnormal_limbs/digits/tail_de	0.94957342
68	MP0006054_spinal_hemorrhage	0.94756381
69	MP0009333_abnormal_splenocyte_physiolog	0.93329911
70	MP0009697_abnormal_copulation	0.93313670
71	MP0004142_abnormal_muscle_tone	0.93107818
72	MP0005167_abnormal_blood-brain_barrier	0.90376106
73	MP0001984_abnormal_olfaction	0.89278942
74	MP0001119_abnormal_female_reproductive	0.88753109
75	MP0001905_abnormal_dopamine_level	0.87341211
76	MP0003938_abnormal_ear_development	0.86938914
77	MP0000358_abnormal_cell_content/	0.84689212
78	MP0000490_abnormal_crypts_of	0.84298637
79	MP0004147_increased_porphyrin_level	0.83096078
80	MP0001929_abnormal_gametogenesis	0.83002107
81	MP0000653_abnormal_sex_gland	0.80651808
82	MP0002837_dystrophic_cardiac_calcinosis	0.79681161
83	MP0002723_abnormal_immune_serum	0.78916545
84	MP0001145_abnormal_male_reproductive	0.78771744
85	MP0001873_stomach_inflammation	0.78580922
86	MP0002751_abnormal_autonomic_nervous	0.78261862
87	MP0004133_heterotaxia	0.76972948
88	MP0005195_abnormal_posterior_eye	0.74348919
89	MP0005391_vision/eye_phenotype	0.73990834
90	MP0002095_abnormal_skin_pigmentation	0.73796821
91	MP0004885_abnormal_endolymph	0.71410379
92	MP0002210_abnormal_sex_determination	0.71219189
93	MP0002148_abnormal_hypersensitivity_rea	0.70905458
94	MP0002282_abnormal_trachea_morphology	0.69868243
95	MP0004043_abnormal_pH_regulation	0.68254847
96	MP0003045_fibrosis	0.67352317
97	MP0005379_endocrine/exocrine_gland_phen	0.67174157
98	MP0001485_abnormal_pinna_reflex	0.66675255
99	MP0005310_abnormal_salivary_gland	0.65054675
100	MP0001819_abnormal_immune_cell	0.65031466

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperglycinemia (HP:0002154)	5.00135492
2	Methylmalonic acidemia (HP:0002912)	4.44399757
3	Acute necrotizing encephalopathy (HP:0006965)	4.00389033
4	Acute encephalopathy (HP:0006846)	3.82710228
5	Progressive macrocephaly (HP:0004481)	3.42719144
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.39681608
7	Methylmalonic aciduria (HP:0012120)	3.38915496
8	Mitochondrial inheritance (HP:0001427)	3.36485249
9	Increased hepatocellular lipid droplets (HP:0006565)	3.26188438
10	Increased CSF lactate (HP:0002490)	3.22899776
11	Abnormality of serine family amino acid metabolism (HP:0010894)	3.17063187
12	Abnormality of glycine metabolism (HP:0010895)	3.17063187
13	Stomatitis (HP:0010280)	3.11912818
14	Lipid accumulation in hepatocytes (HP:0006561)	3.09354763
15	Pancreatic fibrosis (HP:0100732)	3.08204245
16	Abnormality of the ileum (HP:0001549)	3.00061128
17	Hepatocellular necrosis (HP:0001404)	2.96405144
18	Meckel diverticulum (HP:0002245)	2.93210349
19	Pancreatic cysts (HP:0001737)	2.90072415
20	Pendular nystagmus (HP:0012043)	2.82439758
21	Abnormality of serum amino acid levels (HP:0003112)	2.82192672
22	True hermaphroditism (HP:0010459)	2.80998873
23	Congenital stationary night blindness (HP:0007642)	2.79942200
24	3-Methylglutaconic aciduria (HP:0003535)	2.79171601
25	Cerebral edema (HP:0002181)	2.76869408
26	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.73625712
27	Hepatic necrosis (HP:0002605)	2.72281703
28	Hyperglycinuria (HP:0003108)	2.63167632
29	Abnormality of vitamin B metabolism (HP:0004340)	2.56512305
30	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.56288516
31	Abolished electroretinogram (ERG) (HP:0000550)	2.55004378
32	Colon cancer (HP:0003003)	2.54801693
33	Abnormality of alanine metabolism (HP:0010916)	2.54755998
34	Hyperalaninemia (HP:0003348)	2.54755998
35	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.54755998
36	Pancytopenia (HP:0001876)	2.46968724
37	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.43439639
38	Dicarboxylic aciduria (HP:0003215)	2.43439639
39	Hypoproteinemia (HP:0003075)	2.43018339
40	Abnormality of the preputium (HP:0100587)	2.40858044
41	Lethargy (HP:0001254)	2.39143765
42	Attenuation of retinal blood vessels (HP:0007843)	2.37510993
43	Renal Fanconi syndrome (HP:0001994)	2.36801738
44	Abnormality of methionine metabolism (HP:0010901)	2.34063008
45	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.29362294
46	Aplasia/hypoplasia of the uterus (HP:0008684)	2.29083734
47	Congenital, generalized hypertrichosis (HP:0004540)	2.27111054
48	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.26369042
49	IgG deficiency (HP:0004315)	2.24268889
50	Increased serum lactate (HP:0002151)	2.24003050
51	Renal cortical cysts (HP:0000803)	2.23829111
52	Abnormality of DNA repair (HP:0003254)	2.23309885
53	Decreased central vision (HP:0007663)	2.20585984
54	Optic disc pallor (HP:0000543)	2.19594501
55	Reduced antithrombin III activity (HP:0001976)	2.17057532
56	Lactic acidosis (HP:0003128)	2.16590179
57	Increased intramyocellular lipid droplets (HP:0012240)	2.13147829
58	Type I transferrin isoform profile (HP:0003642)	2.11526070
59	Medial flaring of the eyebrow (HP:0010747)	2.10576237
60	Thyroid-stimulating hormone excess (HP:0002925)	2.10176172
61	Abnormality of the renal cortex (HP:0011035)	2.09771713
62	Exertional dyspnea (HP:0002875)	2.07809064
63	Progressive inability to walk (HP:0002505)	2.04919581
64	Abnormality of chromosome stability (HP:0003220)	2.04449175
65	Leukodystrophy (HP:0002415)	2.04229911
66	Clubbing of toes (HP:0100760)	2.04189683
67	Abnormal glycosylation (HP:0012345)	2.01545956
68	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.01545956
69	Abnormal protein N-linked glycosylation (HP:0012347)	2.01545956
70	Abnormal protein glycosylation (HP:0012346)	2.01545956
71	Absent thumb (HP:0009777)	1.99773171
72	Nephronophthisis (HP:0000090)	1.98156146
73	Type 2 muscle fiber atrophy (HP:0003554)	1.96379524
74	Abnormality of the labia minora (HP:0012880)	1.94367700
75	Increased serum pyruvate (HP:0003542)	1.92113643
76	Abnormality of midbrain morphology (HP:0002418)	1.90482906
77	Molar tooth sign on MRI (HP:0002419)	1.90482906
78	Pancreatic islet-cell hyperplasia (HP:0004510)	1.89810205
79	Abnormality of the pons (HP:0007361)	1.88047626
80	Hypoplasia of the pons (HP:0012110)	1.88016062
81	Exercise intolerance (HP:0003546)	1.87880447
82	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.87029233
83	Hypoplasia of the uterus (HP:0000013)	1.85776173
84	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.84512916
85	Chromsome breakage (HP:0040012)	1.84435719
86	Respiratory difficulties (HP:0002880)	1.82031219
87	CNS demyelination (HP:0007305)	1.80786439
88	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.80644342
89	Respiratory failure (HP:0002878)	1.80331969
90	Duodenal stenosis (HP:0100867)	1.80031271
91	Small intestinal stenosis (HP:0012848)	1.80031271
92	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78793604
93	Muscle fiber atrophy (HP:0100295)	1.75542066
94	Abnormality of macular pigmentation (HP:0008002)	1.75332927
95	Abnormality of the renal collecting system (HP:0004742)	1.74130413
96	Triphalangeal thumb (HP:0001199)	1.74004979
97	Opisthotonus (HP:0002179)	1.73962086
98	Megaloblastic anemia (HP:0001889)	1.73466193
99	Congenital primary aphakia (HP:0007707)	1.72532446
100	Emotional lability (HP:0000712)	1.71930960

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.95808774
2	SRPK1	3.03191645
3	VRK2	2.79378097
4	PBK	2.67430727
5	TLK1	2.66373857
6	MKNK1	2.53790876
7	TSSK6	2.49556010
8	TXK	2.37570435
9	BCKDK	2.37313042
10	BCR	2.33933430
11	MAP4K2	2.28366084
12	BUB1	2.19677096
13	NUAK1	2.10992283
14	VRK1	2.05693797
15	STK16	2.01855971
16	ADRBK2	1.92961602
17	TAOK3	1.79867884
18	CDC7	1.74464138
19	EIF2AK3	1.72370733
20	WNK3	1.67480050
21	CAMKK2	1.64865404
22	TRIM28	1.55930800
23	PLK3	1.55777179
24	PINK1	1.55476819
25	CSNK1G3	1.50732795
26	MST4	1.49877528
27	CSNK1G2	1.36800375
28	CSNK1A1L	1.32007499
29	ERBB3	1.30699397
30	NEK9	1.28978063
31	CSNK1G1	1.28946557
32	TAF1	1.26560090
33	INSRR	1.25901771
34	EIF2AK2	1.24734676
35	BRD4	1.24475369
36	GRK1	1.22917175
37	MAP4K1	1.21990697
38	NEK1	1.21660321
39	EPHA4	1.10775154
40	IKBKE	1.03174898
41	DYRK2	1.02717014
42	RPS6KA5	1.01794052
43	GRK6	0.87901817
44	PLK1	0.87818867
45	WEE1	0.87450541
46	DYRK3	0.85487610
47	ATR	0.85078285
48	TIE1	0.83804410
49	TEC	0.83040500
50	MAPK13	0.82657065
51	MKNK2	0.81630865
52	RPS6KA4	0.81549077
53	NME1	0.78555337
54	AURKB	0.75603984
55	CHEK2	0.72808942
56	TNIK	0.68884112
57	ERBB2	0.68347371
58	STK4	0.67697186
59	KIT	0.67465359
60	MATK	0.64028532
61	FRK	0.63653139
62	KDR	0.63085319
63	IKBKB	0.63026701
64	ITK	0.60278822
65	CAMK4	0.57648473
66	ALK	0.54999531
67	OXSR1	0.53491484
68	PASK	0.53468336
69	PLK2	0.53300689
70	CSNK2A1	0.53082559
71	PKN1	0.52943037
72	PIM1	0.46728121
73	AURKA	0.45488505
74	PAK4	0.43743805
75	MAP2K7	0.42957942
76	SYK	0.42123412
77	ATM	0.41435317
78	CSNK1A1	0.40420963
79	BTK	0.39710152
80	CSNK2A2	0.38840422
81	LYN	0.38689554
82	PRKCE	0.38306380
83	BMPR1B	0.36762972
84	UHMK1	0.35890634
85	PLK4	0.35839133
86	TAOK1	0.35483978
87	PDK2	0.35202692
88	CAMK1	0.34201847
89	MAP3K4	0.33681383
90	IGF1R	0.32092024
91	CHUK	0.30746787
92	CHEK1	0.30125016
93	JAK3	0.29128741
94	PRKCQ	0.29039721
95	WNK4	0.28210283
96	DAPK1	0.26256437
97	CSF1R	0.26032618
98	SIK3	0.25443367
99	EIF2AK1	0.24276077
100	HCK	0.24256625

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.47224675
2	Protein export_Homo sapiens_hsa03060	3.36498644
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.95182488
4	Spliceosome_Homo sapiens_hsa03040	2.75929736
5	Parkinsons disease_Homo sapiens_hsa05012	2.65453689
6	RNA polymerase_Homo sapiens_hsa03020	2.56512592
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.51765003
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.49142451
9	Homologous recombination_Homo sapiens_hsa03440	2.45821567
10	Mismatch repair_Homo sapiens_hsa03430	2.41106009
11	Ribosome_Homo sapiens_hsa03010	2.39048172
12	Sulfur metabolism_Homo sapiens_hsa00920	2.33054384
13	Non-homologous end-joining_Homo sapiens_hsa03450	2.22664057
14	DNA replication_Homo sapiens_hsa03030	2.20000659
15	One carbon pool by folate_Homo sapiens_hsa00670	2.09154496
16	RNA degradation_Homo sapiens_hsa03018	2.01054521
17	Propanoate metabolism_Homo sapiens_hsa00640	2.00273585
18	RNA transport_Homo sapiens_hsa03013	1.95729758
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.89604004
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.86961134
21	Basal transcription factors_Homo sapiens_hsa03022	1.82915744
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.78141760
23	Base excision repair_Homo sapiens_hsa03410	1.73806653
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.67469066
25	Huntingtons disease_Homo sapiens_hsa05016	1.66116327
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.55842475
27	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.53162511
28	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.44279081
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.41588598
30	Alzheimers disease_Homo sapiens_hsa05010	1.38381804
31	Purine metabolism_Homo sapiens_hsa00230	1.36836290
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.31931551
33	Phototransduction_Homo sapiens_hsa04744	1.28811228
34	Asthma_Homo sapiens_hsa05310	1.27982199
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.27570285
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.25722089
37	Peroxisome_Homo sapiens_hsa04146	1.17527771
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14002065
39	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.06181844
40	Allograft rejection_Homo sapiens_hsa05330	1.04878671
41	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.04824482
42	Primary immunodeficiency_Homo sapiens_hsa05340	1.03492529
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.02554318
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.02033999
45	Butanoate metabolism_Homo sapiens_hsa00650	1.01315917
46	Selenocompound metabolism_Homo sapiens_hsa00450	1.00371070
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.97979718
48	Caffeine metabolism_Homo sapiens_hsa00232	0.92878453
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.88977991
50	Alcoholism_Homo sapiens_hsa05034	0.84883216
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.83377537
52	Steroid biosynthesis_Homo sapiens_hsa00100	0.80413319
53	Pyruvate metabolism_Homo sapiens_hsa00620	0.77532903
54	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.75062227
55	Linoleic acid metabolism_Homo sapiens_hsa00591	0.74610300
56	Glutathione metabolism_Homo sapiens_hsa00480	0.74171099
57	mRNA surveillance pathway_Homo sapiens_hsa03015	0.73599459
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.70888281
59	Sulfur relay system_Homo sapiens_hsa04122	0.70762487
60	Metabolic pathways_Homo sapiens_hsa01100	0.69826503
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.69668415
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66023227
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.61545267
64	Fatty acid elongation_Homo sapiens_hsa00062	0.59100963
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.58576265
66	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.56190568
67	Graft-versus-host disease_Homo sapiens_hsa05332	0.54193323
68	Regulation of autophagy_Homo sapiens_hsa04140	0.54180369
69	Folate biosynthesis_Homo sapiens_hsa00790	0.52729503
70	Type I diabetes mellitus_Homo sapiens_hsa04940	0.52346356
71	Cell cycle_Homo sapiens_hsa04110	0.51539120
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50335018
73	Retinol metabolism_Homo sapiens_hsa00830	0.49528002
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48510026
75	Nicotine addiction_Homo sapiens_hsa05033	0.45063335
76	Carbon metabolism_Homo sapiens_hsa01200	0.44206038
77	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.44141904
78	Olfactory transduction_Homo sapiens_hsa04740	0.43218409
79	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.42814411
80	Antigen processing and presentation_Homo sapiens_hsa04612	0.42173310
81	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.41721444
82	Viral carcinogenesis_Homo sapiens_hsa05203	0.41440599
83	Cardiac muscle contraction_Homo sapiens_hsa04260	0.40434456
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39977373
85	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39813862
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39535069
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38752085
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37057382
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36582348
90	Ether lipid metabolism_Homo sapiens_hsa00565	0.35116242
91	p53 signaling pathway_Homo sapiens_hsa04115	0.34327464
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.33809189
93	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.32439683
94	Chemical carcinogenesis_Homo sapiens_hsa05204	0.32131857
95	Collecting duct acid secretion_Homo sapiens_hsa04966	0.31449506
96	Taste transduction_Homo sapiens_hsa04742	0.27873125
97	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.26524988
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.23081458
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.22873882
100	Rheumatoid arthritis_Homo sapiens_hsa05323	0.21095221

HNRNPA1P52

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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