ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	5.35862253
2	ribosomal small subunit assembly (GO:0000028)	5.09230530
3	chaperone-mediated protein transport (GO:0072321)	4.92846251
4	chromatin remodeling at centromere (GO:0031055)	4.69142979
5	CENP-A containing nucleosome assembly (GO:0034080)	4.66431891
6	proteasome assembly (GO:0043248)	4.58684516
7	purine nucleobase biosynthetic process (GO:0009113)	4.08978898
8	kinetochore assembly (GO:0051382)	4.08797535
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.08059536
10	histone exchange (GO:0043486)	3.90214606
11	ribosomal large subunit biogenesis (GO:0042273)	3.90161634
12	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.89549237
13	DNA deamination (GO:0045006)	3.83271001
14	kinetochore organization (GO:0051383)	3.83094130
15	ATP synthesis coupled proton transport (GO:0015986)	3.78970873
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.78970873
17	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.65889696
18	behavioral response to nicotine (GO:0035095)	3.52938265
19	maturation of 5.8S rRNA (GO:0000460)	3.49411642
20	rRNA modification (GO:0000154)	3.47460214
21	rRNA processing (GO:0006364)	3.46820396
22	establishment of integrated proviral latency (GO:0075713)	3.46519963
23	cullin deneddylation (GO:0010388)	3.46395718
24	rRNA metabolic process (GO:0016072)	3.41341167
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.36307042
26	protein complex biogenesis (GO:0070271)	3.34274979
27	DNA replication checkpoint (GO:0000076)	3.33694943
28	spliceosomal snRNP assembly (GO:0000387)	3.31609420
29	DNA replication-independent nucleosome assembly (GO:0006336)	3.25613785
30	DNA replication-independent nucleosome organization (GO:0034724)	3.25613785
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.22809830
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.22809830
33	NADH dehydrogenase complex assembly (GO:0010257)	3.22809830
34	nucleobase biosynthetic process (GO:0046112)	3.19055866
35	mitochondrial respiratory chain complex assembly (GO:0033108)	3.18961051
36	heme transport (GO:0015886)	3.18239297
37	protein neddylation (GO:0045116)	3.16637570
38	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.16535507
39	peptidyl-histidine modification (GO:0018202)	3.16454043
40	water-soluble vitamin biosynthetic process (GO:0042364)	3.16230672
41	rRNA methylation (GO:0031167)	3.15074517
42	protein targeting to mitochondrion (GO:0006626)	3.13429444
43	protein deneddylation (GO:0000338)	3.11896552
44	platelet dense granule organization (GO:0060155)	3.09553089
45	protein K6-linked ubiquitination (GO:0085020)	3.03653711
46	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.03279774
47	ubiquinone metabolic process (GO:0006743)	3.02658639
48	ribonucleoprotein complex biogenesis (GO:0022613)	2.96686995
49	respiratory electron transport chain (GO:0022904)	2.94039756
50	ribosome assembly (GO:0042255)	2.93927929
51	protein localization to kinetochore (GO:0034501)	2.93898516
52	cellular component biogenesis (GO:0044085)	2.92697288
53	electron transport chain (GO:0022900)	2.91079967
54	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.90280918
55	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.90280918
56	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.90280918
57	spindle assembly involved in mitosis (GO:0090307)	2.89456267
58	termination of RNA polymerase III transcription (GO:0006386)	2.89188630
59	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.89188630
60	protein localization to mitochondrion (GO:0070585)	2.86642057
61	neuron fate determination (GO:0048664)	2.84833222
62	ribosomal small subunit biogenesis (GO:0042274)	2.84252070
63	pseudouridine synthesis (GO:0001522)	2.81645765
64	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.77282057
65	DNA replication-dependent nucleosome organization (GO:0034723)	2.77078803
66	DNA replication-dependent nucleosome assembly (GO:0006335)	2.77078803
67	mitochondrial RNA metabolic process (GO:0000959)	2.76792069
68	establishment of protein localization to mitochondrion (GO:0072655)	2.76300532
69	negative regulation of T cell differentiation in thymus (GO:0033085)	2.74741744
70	translational termination (GO:0006415)	2.72420665
71	peptidyl-threonine dephosphorylation (GO:0035970)	2.71439517
72	ribosome biogenesis (GO:0042254)	2.70317685
73	GMP metabolic process (GO:0046037)	2.70010220
74	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.69528038
75	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.67648363
76	IMP biosynthetic process (GO:0006188)	2.66741165
77	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.65757020
78	regulation of mitotic spindle checkpoint (GO:1903504)	2.65757020
79	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.65405752
80	viral transcription (GO:0019083)	2.65211363
81	positive regulation of chromosome segregation (GO:0051984)	2.64566925
82	GPI anchor metabolic process (GO:0006505)	2.64520536
83	ncRNA metabolic process (GO:0034660)	2.63917616
84	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.63746491
85	DNA damage response, detection of DNA damage (GO:0042769)	2.61850468
86	guanosine-containing compound biosynthetic process (GO:1901070)	2.59702106
87	regulation of mitotic spindle organization (GO:0060236)	2.57482859
88	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.56883225
89	translation (GO:0006412)	2.56832940
90	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.56690640
91	ncRNA processing (GO:0034470)	2.56321627
92	formation of translation preinitiation complex (GO:0001731)	2.55792213
93	regulation of spindle organization (GO:0090224)	2.54706970
94	neuron remodeling (GO:0016322)	2.54118491
95	DNA ligation (GO:0006266)	2.53561752
96	respiratory chain complex IV assembly (GO:0008535)	2.51518238
97	DNA catabolic process, exonucleolytic (GO:0000738)	2.50449314
98	GTP biosynthetic process (GO:0006183)	2.48654176
99	translational initiation (GO:0006413)	2.46928196
100	L-fucose metabolic process (GO:0042354)	2.46752337

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.43196890
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.89670717
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.87877485
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.68261111
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.12193213
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.08808401
7	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.91643961
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.90217487
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.89741268
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.89218350
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.88841559
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.82751946
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.72157532
14	VDR_22108803_ChIP-Seq_LS180_Human	2.67290020
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.67257143
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.66094741
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.55147251
18	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.54508912
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.51885637
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.25988618
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.24239240
22	EWS_26573619_Chip-Seq_HEK293_Human	2.15426936
23	FOXP3_21729870_ChIP-Seq_TREG_Human	2.05901451
24	TTF2_22483619_ChIP-Seq_HELA_Human	1.98884755
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.95122909
26	FUS_26573619_Chip-Seq_HEK293_Human	1.87732221
27	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.86632553
28	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.86402980
29	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.85979727
30	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.85856312
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.84522376
32	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.82724294
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.80636111
34	ZNF274_21170338_ChIP-Seq_K562_Hela	1.78904221
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.76018999
36	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.74537653
37	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68094967
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.64849810
39	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.64194848
40	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.56068159
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.55617497
42	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.55056264
43	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.53977221
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.47211783
45	XRN2_22483619_ChIP-Seq_HELA_Human	1.45686619
46	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.44894187
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.44606750
48	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43084594
49	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.42785211
50	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.35161692
51	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.35019931
52	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.33675859
53	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.33258924
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31885428
55	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.31741774
56	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.26602829
57	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.26580622
58	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.26128083
59	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.24565118
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21187189
61	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.20060305
62	P300_19829295_ChIP-Seq_ESCs_Human	1.19232793
63	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.19039650
64	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.16695804
65	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.16477292
66	TAF15_26573619_Chip-Seq_HEK293_Human	1.14255691
67	IGF1R_20145208_ChIP-Seq_DFB_Human	1.13967753
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.12214438
69	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11405589
70	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.10260807
71	GABP_19822575_ChIP-Seq_HepG2_Human	1.06216552
72	GBX2_23144817_ChIP-Seq_PC3_Human	1.06157441
73	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.06025277
74	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.05596347
75	TP53_22573176_ChIP-Seq_HFKS_Human	1.04891900
76	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04739839
77	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.03067595
78	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.02309349
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01822139
80	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.01644665
81	ER_23166858_ChIP-Seq_MCF-7_Human	0.99951863
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99468620
83	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98970319
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97595586
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97595586
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96690668
87	AR_21909140_ChIP-Seq_LNCAP_Human	0.93857605
88	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.93596333
89	SOX2_19829295_ChIP-Seq_ESCs_Human	0.92852537
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.92852537
91	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.92750705
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92293931
93	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.90551508
94	NCOR_22424771_ChIP-Seq_293T_Human	0.90391672
95	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.89023292
96	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.88373530
97	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.86656706
98	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.85779593
99	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.83477710
100	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.81546863

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.84866015
2	MP0001188_hyperpigmentation	4.17267323
3	MP0004147_increased_porphyrin_level	3.37720370
4	MP0005187_abnormal_penis_morphology	3.08754080
5	MP0002102_abnormal_ear_morphology	2.91459555
6	MP0006292_abnormal_olfactory_placode	2.82853243
7	MP0005174_abnormal_tail_pigmentation	2.74067814
8	MP0008877_abnormal_DNA_methylation	2.61806626
9	MP0003693_abnormal_embryo_hatching	2.54370943
10	MP0010094_abnormal_chromosome_stability	2.45172947
11	MP0000537_abnormal_urethra_morphology	2.32894682
12	MP0002160_abnormal_reproductive_system	2.21840393
13	MP0008058_abnormal_DNA_repair	2.17846247
14	MP0008057_abnormal_DNA_replication	2.16751578
15	MP0002938_white_spotting	2.10573379
16	MP0006072_abnormal_retinal_apoptosis	2.10310301
17	MP0004885_abnormal_endolymph	2.04346734
18	MP0003718_maternal_effect	2.01366618
19	MP0003880_abnormal_central_pattern	1.89301682
20	MP0002638_abnormal_pupillary_reflex	1.89041200
21	MP0008872_abnormal_physiological_respon	1.88324926
22	MP0003111_abnormal_nucleus_morphology	1.84201980
23	MP0008007_abnormal_cellular_replicative	1.82055651
24	MP0000372_irregular_coat_pigmentation	1.78089721
25	MP0003786_premature_aging	1.76580491
26	MP0003937_abnormal_limbs/digits/tail_de	1.72947185
27	MP0004957_abnormal_blastocyst_morpholog	1.72604984
28	MP0002736_abnormal_nociception_after	1.55789929
29	MP0003077_abnormal_cell_cycle	1.53144831
30	MP0003315_abnormal_perineum_morphology	1.52246973
31	MP0002751_abnormal_autonomic_nervous	1.51520198
32	MP0005646_abnormal_pituitary_gland	1.50100194
33	MP0008875_abnormal_xenobiotic_pharmacok	1.43479063
34	MP0002138_abnormal_hepatobiliary_system	1.40672539
35	MP0005389_reproductive_system_phenotype	1.40142544
36	MP0001984_abnormal_olfaction	1.37225066
37	MP0002095_abnormal_skin_pigmentation	1.36688192
38	MP0008932_abnormal_embryonic_tissue	1.36582500
39	MP0001485_abnormal_pinna_reflex	1.34829152
40	MP0010386_abnormal_urinary_bladder	1.33806354
41	MP0000647_abnormal_sebaceous_gland	1.31240434
42	MP0001293_anophthalmia	1.28490211
43	MP0000049_abnormal_middle_ear	1.25370890
44	MP0009053_abnormal_anal_canal	1.23888096
45	MP0005253_abnormal_eye_physiology	1.23512092
46	MP0008789_abnormal_olfactory_epithelium	1.21071112
47	MP0001968_abnormal_touch/_nociception	1.18884829
48	MP0005084_abnormal_gallbladder_morpholo	1.17111916
49	MP0008873_increased_physiological_sensi	1.16258336
50	MP0002277_abnormal_respiratory_mucosa	1.15463486
51	MP0004133_heterotaxia	1.12916313
52	MP0003119_abnormal_digestive_system	1.11906593
53	MP0001348_abnormal_lacrimal_gland	1.09398207
54	MP0005085_abnormal_gallbladder_physiolo	1.07687213
55	MP0001502_abnormal_circadian_rhythm	1.07678665
56	MP0001730_embryonic_growth_arrest	1.07113558
57	MP0005551_abnormal_eye_electrophysiolog	1.07032903
58	MP0000015_abnormal_ear_pigmentation	1.07021394
59	MP0006036_abnormal_mitochondrial_physio	1.05424306
60	MP0003567_abnormal_fetal_cardiomyocyte	1.01655616
61	MP0000653_abnormal_sex_gland	0.96863994
62	MP0009250_abnormal_appendicular_skeleto	0.96476148
63	MP0001145_abnormal_male_reproductive	0.90957176
64	MP0001905_abnormal_dopamine_level	0.89361733
65	MP0003938_abnormal_ear_development	0.86300628
66	MP0002254_reproductive_system_inflammat	0.86263398
67	MP0001764_abnormal_homeostasis	0.86237764
68	MP0002210_abnormal_sex_determination	0.85905843
69	MP0000631_abnormal_neuroendocrine_gland	0.85017481
70	MP0001697_abnormal_embryo_size	0.84036256
71	MP0006035_abnormal_mitochondrial_morpho	0.83097821
72	MP0001929_abnormal_gametogenesis	0.82301769
73	MP0002272_abnormal_nervous_system	0.78678253
74	MP0002932_abnormal_joint_morphology	0.78428669
75	MP0002282_abnormal_trachea_morphology	0.78351445
76	MP0001119_abnormal_female_reproductive	0.77976833
77	MP0001529_abnormal_vocalization	0.75535111
78	MP0003941_abnormal_skin_development	0.74763139
79	MP0002876_abnormal_thyroid_physiology	0.74358163
80	MP0003122_maternal_imprinting	0.73441091
81	MP0005395_other_phenotype	0.68386623
82	MP0005645_abnormal_hypothalamus_physiol	0.67654891
83	MP0002177_abnormal_outer_ear	0.67113827
84	MP0003698_abnormal_male_reproductive	0.66183596
85	MP0005391_vision/eye_phenotype	0.65813073
86	MP0003878_abnormal_ear_physiology	0.65405351
87	MP0005377_hearing/vestibular/ear_phenot	0.65405351
88	MP0004142_abnormal_muscle_tone	0.62494237
89	MP0004145_abnormal_muscle_electrophysio	0.62349573
90	MP0001286_abnormal_eye_development	0.61219955
91	MP0009765_abnormal_xenobiotic_induced	0.60416541
92	MP0003942_abnormal_urinary_system	0.59940781
93	MP0001963_abnormal_hearing_physiology	0.59614520
94	MP0000026_abnormal_inner_ear	0.59368530
95	MP0001881_abnormal_mammary_gland	0.58196611
96	MP0004782_abnormal_surfactant_physiolog	0.58004784
97	MP0000538_abnormal_urinary_bladder	0.57460383
98	MP0002085_abnormal_embryonic_tissue	0.56609605
99	MP0006276_abnormal_autonomic_nervous	0.56319478
100	MP0003186_abnormal_redox_activity	0.56269802

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.92772766
2	Acute necrotizing encephalopathy (HP:0006965)	3.85563892
3	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.54762749
4	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.38378445
5	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.38378445
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.38109463
7	Acute encephalopathy (HP:0006846)	3.37317058
8	Progressive macrocephaly (HP:0004481)	3.28577936
9	Mitochondrial inheritance (HP:0001427)	3.03274626
10	Pancreatic cysts (HP:0001737)	2.93359007
11	Increased CSF lactate (HP:0002490)	2.87662056
12	Abnormality of the middle phalanges of the toes (HP:0010183)	2.82690631
13	Absent/shortened dynein arms (HP:0200106)	2.82059356
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.82059356
15	Bile duct proliferation (HP:0001408)	2.79136950
16	Abnormal biliary tract physiology (HP:0012439)	2.79136950
17	Pancreatic fibrosis (HP:0100732)	2.74459362
18	Pendular nystagmus (HP:0012043)	2.70868743
19	Methylmalonic acidemia (HP:0002912)	2.64668488
20	Medial flaring of the eyebrow (HP:0010747)	2.59612215
21	Reticulocytopenia (HP:0001896)	2.57354321
22	Neonatal respiratory distress (HP:0002643)	2.57342631
23	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.53252267
24	Abnormality of alanine metabolism (HP:0010916)	2.52874304
25	Hyperalaninemia (HP:0003348)	2.52874304
26	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.52874304
27	Macrocytic anemia (HP:0001972)	2.50553816
28	Cerebral edema (HP:0002181)	2.49843007
29	Increased hepatocellular lipid droplets (HP:0006565)	2.48550470
30	Methylmalonic aciduria (HP:0012120)	2.48451335
31	Abnormality of midbrain morphology (HP:0002418)	2.48071321
32	Molar tooth sign on MRI (HP:0002419)	2.48071321
33	Hepatocellular necrosis (HP:0001404)	2.45001633
34	Abnormality of the labia minora (HP:0012880)	2.42019380
35	Hepatic necrosis (HP:0002605)	2.39546961
36	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.39540816
37	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.37663760
38	Colon cancer (HP:0003003)	2.37398175
39	Lactic acidosis (HP:0003128)	2.36465340
40	True hermaphroditism (HP:0010459)	2.35804787
41	Esophageal atresia (HP:0002032)	2.32108135
42	Sensory axonal neuropathy (HP:0003390)	2.31815447
43	Respiratory failure (HP:0002878)	2.31806318
44	Increased serum lactate (HP:0002151)	2.29845537
45	Abnormality of serum amino acid levels (HP:0003112)	2.29613750
46	Hyperglycinemia (HP:0002154)	2.28660359
47	Hypochromic microcytic anemia (HP:0004840)	2.27331906
48	Abnormal number of erythroid precursors (HP:0012131)	2.23241405
49	Ectopic kidney (HP:0000086)	2.16382359
50	Lipid accumulation in hepatocytes (HP:0006561)	2.15759605
51	Chronic otitis media (HP:0000389)	2.15200019
52	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.10769632
53	Pancytopenia (HP:0001876)	2.10162451
54	Optic disc pallor (HP:0000543)	2.06695229
55	Keratoconus (HP:0000563)	2.06626614
56	Increased corneal curvature (HP:0100692)	2.06626614
57	Leukodystrophy (HP:0002415)	2.05925646
58	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.05350106
59	Supernumerary spleens (HP:0009799)	2.04899780
60	Nephronophthisis (HP:0000090)	2.02547491
61	Hypothermia (HP:0002045)	2.02528294
62	Lethargy (HP:0001254)	2.01227279
63	Meckel diverticulum (HP:0002245)	1.99618764
64	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.98394367
65	Abolished electroretinogram (ERG) (HP:0000550)	1.97432481
66	Abnormality of the renal cortex (HP:0011035)	1.97054803
67	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.96123260
68	Postaxial foot polydactyly (HP:0001830)	1.94785669
69	Chromsome breakage (HP:0040012)	1.93922442
70	Degeneration of anterior horn cells (HP:0002398)	1.92405795
71	Abnormality of the anterior horn cell (HP:0006802)	1.92405795
72	Ependymoma (HP:0002888)	1.92321926
73	Aplastic anemia (HP:0001915)	1.91392407
74	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.89375996
75	Abnormality of the ileum (HP:0001549)	1.87985910
76	Absent thumb (HP:0009777)	1.87863092
77	Triphalangeal thumb (HP:0001199)	1.87832504
78	Absent radius (HP:0003974)	1.86765403
79	Confusion (HP:0001289)	1.86499420
80	Congenital primary aphakia (HP:0007707)	1.84837889
81	Abnormality of methionine metabolism (HP:0010901)	1.83431406
82	Abnormality of cells of the erythroid lineage (HP:0012130)	1.83234952
83	Cleft eyelid (HP:0000625)	1.78816442
84	Aplasia involving forearm bones (HP:0009822)	1.78017409
85	Absent forearm bone (HP:0003953)	1.78017409
86	Exercise intolerance (HP:0003546)	1.76373663
87	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.75206793
88	Carpal bone hypoplasia (HP:0001498)	1.74521576
89	Gait imbalance (HP:0002141)	1.74006853
90	Anencephaly (HP:0002323)	1.73055994
91	Tubular atrophy (HP:0000092)	1.72022185
92	Increased intramyocellular lipid droplets (HP:0012240)	1.71660030
93	Acute myeloid leukemia (HP:0004808)	1.70883883
94	Short hallux (HP:0010109)	1.70414389
95	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.69664420
96	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.69290027
97	Megaloblastic anemia (HP:0001889)	1.68486127
98	Hyperglycinuria (HP:0003108)	1.68125198
99	Glioma (HP:0009733)	1.65866843
100	Nephrogenic diabetes insipidus (HP:0009806)	1.65630668

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	4.48891067
2	ZAK	3.68420029
3	CDC7	3.48195606
4	TLK1	3.12936087
5	VRK2	2.74644801
6	NUAK1	2.66610499
7	TSSK6	2.65742249
8	PBK	2.36680290
9	TNIK	2.34087238
10	PLK3	2.28536290
11	SRPK1	2.11943038
12	MKNK1	2.06599569
13	DYRK3	2.04892024
14	VRK1	1.92174859
15	GRK1	1.92038960
16	STK16	1.89789403
17	EIF2AK1	1.83159971
18	INSRR	1.81243073
19	BMPR1B	1.78026492
20	EIF2AK3	1.66966028
21	NEK1	1.66721580
22	TAOK3	1.55937768
23	EPHA4	1.55772314
24	TRIM28	1.55596722
25	WEE1	1.51790165
26	MAP4K2	1.51504947
27	PINK1	1.48003046
28	ADRBK2	1.47023696
29	TTK	1.41398874
30	CSNK1G1	1.40058311
31	NME2	1.40009861
32	MKNK2	1.38425276
33	CSNK1G3	1.37019084
34	PLK4	1.32538512
35	TAF1	1.27776860
36	FRK	1.26655070
37	ATR	1.22185999
38	PLK1	1.17662421
39	CSNK1A1L	1.16375860
40	PLK2	1.12255841
41	RPS6KA4	1.10899492
42	STK39	1.06363831
43	KIT	1.03670894
44	MST4	1.02788650
45	WNK4	1.00312335
46	ALK	0.98101422
47	PDK2	0.97711893
48	ACVR1B	0.96018957
49	CSNK1G2	0.95437895
50	MATK	0.91891457
51	WNK3	0.89518700
52	EIF2AK2	0.85549018
53	OXSR1	0.82888007
54	MUSK	0.75856394
55	AURKB	0.75455776
56	RPS6KA5	0.74849147
57	MINK1	0.74584343
58	CSNK2A1	0.73135079
59	CCNB1	0.72596719
60	CHEK2	0.70163784
61	FGFR2	0.67620516
62	FLT3	0.63843935
63	ERBB3	0.61265179
64	CDK19	0.60725565
65	CSNK2A2	0.60289400
66	CDK3	0.58733774
67	PNCK	0.56993030
68	ATM	0.56648369
69	BCR	0.56202713
70	MAP3K5	0.54408177
71	MAP3K4	0.54027676
72	PASK	0.53694469
73	MAP2K7	0.53581942
74	PKN1	0.51780443
75	PTK2B	0.49065237
76	DYRK2	0.48570226
77	RIPK4	0.48473017
78	AURKA	0.47303898
79	OBSCN	0.46044547
80	NEK2	0.45832426
81	TEC	0.45460401
82	CSNK1A1	0.44093324
83	CSNK1E	0.41438310
84	PRKCG	0.40867082
85	RPS6KB2	0.40552428
86	MAP3K8	0.40283089
87	NME1	0.39683262
88	ADRBK1	0.39649909
89	CHEK1	0.38866165
90	CDK9	0.38781517
91	TIE1	0.37476087
92	GRK5	0.36895013
93	FGFR1	0.35947972
94	PRKDC	0.33035819
95	MAPK7	0.31926490
96	IKBKB	0.31623384
97	ITK	0.31573398
98	STK4	0.31151729
99	PRKG1	0.28312337
100	NLK	0.27792902

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.38810795
2	Ribosome_Homo sapiens_hsa03010	3.30709515
3	Proteasome_Homo sapiens_hsa03050	3.26434225
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.10233814
5	Protein export_Homo sapiens_hsa03060	3.03787225
6	DNA replication_Homo sapiens_hsa03030	2.91464211
7	Parkinsons disease_Homo sapiens_hsa05012	2.70639964
8	RNA polymerase_Homo sapiens_hsa03020	2.45361269
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.35717649
10	Homologous recombination_Homo sapiens_hsa03440	2.25049761
11	Mismatch repair_Homo sapiens_hsa03430	2.07913492
12	RNA degradation_Homo sapiens_hsa03018	1.95437023
13	Huntingtons disease_Homo sapiens_hsa05016	1.95304715
14	Basal transcription factors_Homo sapiens_hsa03022	1.94602228
15	Spliceosome_Homo sapiens_hsa03040	1.88206687
16	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.83190916
17	One carbon pool by folate_Homo sapiens_hsa00670	1.81315263
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.79097603
19	RNA transport_Homo sapiens_hsa03013	1.79077855
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.66413917
21	Base excision repair_Homo sapiens_hsa03410	1.66359992
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59714106
23	Alzheimers disease_Homo sapiens_hsa05010	1.58091582
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.56082100
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.49231518
26	Propanoate metabolism_Homo sapiens_hsa00640	1.46586652
27	Pyruvate metabolism_Homo sapiens_hsa00620	1.46337205
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45875669
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.37578870
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.37386625
31	Asthma_Homo sapiens_hsa05310	1.31655745
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24767302
33	Purine metabolism_Homo sapiens_hsa00230	1.24662160
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.23188558
35	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.22457702
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.17605433
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.14210739
38	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.11074606
39	Cell cycle_Homo sapiens_hsa04110	1.10919814
40	Cardiac muscle contraction_Homo sapiens_hsa04260	1.10807194
41	Phototransduction_Homo sapiens_hsa04744	1.06263396
42	Sulfur metabolism_Homo sapiens_hsa00920	1.01949949
43	Arginine and proline metabolism_Homo sapiens_hsa00330	1.00981230
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.99364567
45	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.99128064
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.98422816
47	Fatty acid elongation_Homo sapiens_hsa00062	0.96426638
48	Peroxisome_Homo sapiens_hsa04146	0.92132355
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.88141722
50	Fatty acid degradation_Homo sapiens_hsa00071	0.82663990
51	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.80249804
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.78886061
53	Folate biosynthesis_Homo sapiens_hsa00790	0.78754551
54	Caffeine metabolism_Homo sapiens_hsa00232	0.78297654
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.76230614
56	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.75370965
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74564457
58	Allograft rejection_Homo sapiens_hsa05330	0.73885064
59	p53 signaling pathway_Homo sapiens_hsa04115	0.73731164
60	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.73426601
61	Olfactory transduction_Homo sapiens_hsa04740	0.72626072
62	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.70708481
63	Metabolic pathways_Homo sapiens_hsa01100	0.66298217
64	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65440272
65	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.64083610
66	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.63845132
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.62926084
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62025308
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60823060
70	ABC transporters_Homo sapiens_hsa02010	0.60549895
71	mRNA surveillance pathway_Homo sapiens_hsa03015	0.60404728
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59649172
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.58103123
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57838415
75	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.57209135
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.56668084
77	Retinol metabolism_Homo sapiens_hsa00830	0.54750794
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52231947
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50014320
80	Alcoholism_Homo sapiens_hsa05034	0.48021579
81	Carbon metabolism_Homo sapiens_hsa01200	0.44620582
82	Oocyte meiosis_Homo sapiens_hsa04114	0.44438084
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41351536
84	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.39542813
85	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.37955864
86	Histidine metabolism_Homo sapiens_hsa00340	0.37306161
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36446138
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.36365507
89	Linoleic acid metabolism_Homo sapiens_hsa00591	0.35269329
90	Butanoate metabolism_Homo sapiens_hsa00650	0.33978968
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31912242
92	Tyrosine metabolism_Homo sapiens_hsa00350	0.29001642
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.28657274
94	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.28180411
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.26792860
96	Glutathione metabolism_Homo sapiens_hsa00480	0.25477283
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.25215773
98	Arginine biosynthesis_Homo sapiens_hsa00220	0.24689911
99	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.24655852
100	Chemical carcinogenesis_Homo sapiens_hsa05204	0.23984440

HNRNPA1P53

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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