ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	7.21055780
2	indolalkylamine metabolic process (GO:0006586)	5.08340325
3	indole-containing compound catabolic process (GO:0042436)	4.85342292
4	indolalkylamine catabolic process (GO:0046218)	4.85342292
5	tryptophan catabolic process (GO:0006569)	4.85342292
6	kynurenine metabolic process (GO:0070189)	4.81103289
7	serotonin metabolic process (GO:0042428)	4.54612264
8	sulfation (GO:0051923)	4.50391343
9	primary amino compound metabolic process (GO:1901160)	4.27979700
10	indole-containing compound metabolic process (GO:0042430)	4.15123615
11	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.07667935
12	tryptophan metabolic process (GO:0006568)	4.00156458
13	gamma-aminobutyric acid transport (GO:0015812)	3.94295218
14	regulation of hippo signaling (GO:0035330)	3.86651932
15	L-fucose catabolic process (GO:0042355)	3.85552716
16	fucose catabolic process (GO:0019317)	3.85552716
17	L-fucose metabolic process (GO:0042354)	3.85552716
18	regulation of posttranscriptional gene silencing (GO:0060147)	3.82328722
19	regulation of gene silencing by miRNA (GO:0060964)	3.82328722
20	regulation of gene silencing by RNA (GO:0060966)	3.82328722
21	cell proliferation in forebrain (GO:0021846)	3.77081260
22	cellular response to ATP (GO:0071318)	3.58977574
23	negative regulation of systemic arterial blood pressure (GO:0003085)	3.51984140
24	interkinetic nuclear migration (GO:0022027)	3.37403613
25	positive regulation of fatty acid oxidation (GO:0046321)	3.25967343
26	detection of light stimulus involved in sensory perception (GO:0050962)	3.25809855
27	detection of light stimulus involved in visual perception (GO:0050908)	3.25809855
28	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.23737178
29	reflex (GO:0060004)	3.21958681
30	neuronal action potential (GO:0019228)	3.13682370
31	membrane depolarization during action potential (GO:0086010)	3.10353854
32	transmission of nerve impulse (GO:0019226)	3.09141554
33	amine catabolic process (GO:0009310)	3.07421286
34	cellular biogenic amine catabolic process (GO:0042402)	3.07421286
35	NAD biosynthetic process (GO:0009435)	3.05767309
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.05410658
37	snRNA transcription (GO:0009301)	3.03778448
38	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.01507170
39	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.00027785
40	protein polyglutamylation (GO:0018095)	2.97677622
41	cellular response to exogenous dsRNA (GO:0071360)	2.95430702
42	negative regulation of response to food (GO:0032096)	2.91632677
43	negative regulation of appetite (GO:0032099)	2.91632677
44	cilium or flagellum-dependent cell motility (GO:0001539)	2.90134542
45	water-soluble vitamin biosynthetic process (GO:0042364)	2.89947725
46	spinal cord motor neuron differentiation (GO:0021522)	2.86798113
47	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.86230093
48	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.86230093
49	regulation of mesoderm development (GO:2000380)	2.86084826
50	negative regulation of mast cell activation (GO:0033004)	2.81562879
51	cellular ketone body metabolic process (GO:0046950)	2.79419309
52	regulation of action potential (GO:0098900)	2.79059062
53	flavonoid metabolic process (GO:0009812)	2.78334523
54	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.74576408
55	response to pheromone (GO:0019236)	2.74195738
56	behavioral response to ethanol (GO:0048149)	2.72502715
57	oxidative demethylation (GO:0070989)	2.72043886
58	parturition (GO:0007567)	2.67888635
59	signal peptide processing (GO:0006465)	2.66196881
60	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.66062274
61	neural tube formation (GO:0001841)	2.63508491
62	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.63410037
63	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.63410037
64	regulation of translation, ncRNA-mediated (GO:0045974)	2.63410037
65	negative regulation of sodium ion transport (GO:0010766)	2.63147973
66	benzene-containing compound metabolic process (GO:0042537)	2.62662813
67	peristalsis (GO:0030432)	2.62613283
68	regulation of DNA endoreduplication (GO:0032875)	2.61824123
69	aromatic amino acid family metabolic process (GO:0009072)	2.61791286
70	somite development (GO:0061053)	2.57287060
71	protein K48-linked deubiquitination (GO:0071108)	2.55998114
72	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.55610319
73	kidney morphogenesis (GO:0060993)	2.55021957
74	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.54325790
75	aromatic amino acid family catabolic process (GO:0009074)	2.53035588
76	cardiovascular system development (GO:0072358)	2.53003598
77	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.52934782
78	cAMP catabolic process (GO:0006198)	2.51311463
79	response to misfolded protein (GO:0051788)	2.51124796
80	axoneme assembly (GO:0035082)	2.49130403
81	epithelial cilium movement (GO:0003351)	2.48805815
82	ketone body metabolic process (GO:1902224)	2.48266427
83	thyroid hormone metabolic process (GO:0042403)	2.46804639
84	DNA deamination (GO:0045006)	2.46437000
85	rhodopsin mediated signaling pathway (GO:0016056)	2.45902000
86	limb development (GO:0060173)	2.44160185
87	appendage development (GO:0048736)	2.44160185
88	nonmotile primary cilium assembly (GO:0035058)	2.43704514
89	membrane repolarization during action potential (GO:0086011)	2.42624332
90	cerebellar Purkinje cell differentiation (GO:0021702)	2.41968078
91	photoreceptor cell maintenance (GO:0045494)	2.41526345
92	regulation of sequestering of triglyceride (GO:0010889)	2.41065793
93	ovulation cycle (GO:0042698)	2.40686949
94	multicellular organism reproduction (GO:0032504)	2.39483031
95	positive regulation of action potential (GO:0045760)	2.38785349
96	cilium movement (GO:0003341)	2.37738372
97	synaptic transmission, cholinergic (GO:0007271)	2.37338999
98	regulation of collateral sprouting (GO:0048670)	2.36723805
99	DNA methylation involved in gamete generation (GO:0043046)	2.36320520
100	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.36311331

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.42008856
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.11074117
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97688681
4	VDR_22108803_ChIP-Seq_LS180_Human	2.86513364
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.64845141
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.42524671
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40741456
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.25612299
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18366421
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16103254
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.05565638
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91094476
13	TAF15_26573619_Chip-Seq_HEK293_Human	1.87720925
14	IGF1R_20145208_ChIP-Seq_DFB_Human	1.85607116
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.85075143
16	P300_19829295_ChIP-Seq_ESCs_Human	1.79030637
17	EWS_26573619_Chip-Seq_HEK293_Human	1.78435069
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76109805
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.74184209
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.72790775
21	FUS_26573619_Chip-Seq_HEK293_Human	1.71421435
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.70590500
23	STAT3_23295773_ChIP-Seq_U87_Human	1.70076974
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67059428
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66215375
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.65575035
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.64893309
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.64664578
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.62127463
30	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.57055933
31	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.56948085
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56543400
33	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.56514351
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.54867133
35	DROSHA_22980978_ChIP-Seq_HELA_Human	1.54330890
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53721673
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53721673
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.51715060
39	TCF4_23295773_ChIP-Seq_U87_Human	1.50953246
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49156818
41	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.48448287
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.47594228
43	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.47551488
44	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.46631815
45	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.45141334
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44908387
47	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.42293924
48	AR_25329375_ChIP-Seq_VCAP_Human	1.39333819
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.37754875
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.36803199
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36803199
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.32135241
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31722256
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31330394
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30830165
56	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.30752335
57	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.29641176
58	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.29603803
59	RNF2_27304074_Chip-Seq_NSC_Mouse	1.29495140
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28535307
61	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.26905885
62	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.25872905
63	TP53_16413492_ChIP-PET_HCT116_Human	1.25232419
64	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.21240257
65	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.20273655
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19669590
67	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.17382091
68	AHR_22903824_ChIP-Seq_MCF-7_Human	1.17352062
69	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.16781807
70	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.16036044
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.15690052
72	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15561027
73	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.15017400
74	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.12852532
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11686235
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10077284
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08790428
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07990915
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07990915
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.07647188
81	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.07564716
82	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.07564716
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.07400428
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06742940
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05683085
86	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.05634620
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05591462
88	KDM2B_26808549_Chip-Seq_REH_Human	1.05435646
89	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05360271
90	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.04948780
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.04754294
92	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.03066765
93	RXR_22108803_ChIP-Seq_LS180_Human	1.02986129
94	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02500910
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02135607
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02135607
97	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01422484
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01401558
99	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.01172423
100	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.01093910

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.41292605
2	MP0000569_abnormal_digit_pigmentation	3.29189719
3	MP0003195_calcinosis	2.98815904
4	MP0001485_abnormal_pinna_reflex	2.45424921
5	MP0005551_abnormal_eye_electrophysiolog	2.42526774
6	MP0002837_dystrophic_cardiac_calcinosis	2.32792804
7	MP0001968_abnormal_touch/_nociception	2.30610678
8	MP0006292_abnormal_olfactory_placode	2.25473798
9	MP0004130_abnormal_muscle_cell	2.17492443
10	MP0009046_muscle_twitch	2.14090913
11	MP0004145_abnormal_muscle_electrophysio	2.09854260
12	MP0005646_abnormal_pituitary_gland	2.08273058
13	MP0009745_abnormal_behavioral_response	2.07662398
14	MP0004885_abnormal_endolymph	2.00962388
15	MP0002102_abnormal_ear_morphology	1.97283284
16	MP0003136_yellow_coat_color	1.92759385
17	MP0002160_abnormal_reproductive_system	1.90427815
18	MP0002272_abnormal_nervous_system	1.89953886
19	MP0004142_abnormal_muscle_tone	1.85360773
20	MP0001501_abnormal_sleep_pattern	1.75767633
21	MP0002876_abnormal_thyroid_physiology	1.75332439
22	MP0008877_abnormal_DNA_methylation	1.74465753
23	MP0003879_abnormal_hair_cell	1.66558416
24	MP0000631_abnormal_neuroendocrine_gland	1.66220239
25	MP0002653_abnormal_ependyma_morphology	1.62220214
26	MP0006276_abnormal_autonomic_nervous	1.61933946
27	MP0008872_abnormal_physiological_respon	1.61620471
28	MP0002736_abnormal_nociception_after	1.59765560
29	MP0002733_abnormal_thermal_nociception	1.58800011
30	MP0002064_seizures	1.57311608
31	MP0002638_abnormal_pupillary_reflex	1.55271521
32	MP0006072_abnormal_retinal_apoptosis	1.54835904
33	MP0004043_abnormal_pH_regulation	1.54549663
34	MP0002735_abnormal_chemical_nociception	1.53583020
35	MP0005253_abnormal_eye_physiology	1.51633589
36	MP0003011_delayed_dark_adaptation	1.51015526
37	MP0005174_abnormal_tail_pigmentation	1.49321517
38	MP0000427_abnormal_hair_cycle	1.48271852
39	MP0001486_abnormal_startle_reflex	1.47699889
40	MP0005389_reproductive_system_phenotype	1.46379270
41	MP0004133_heterotaxia	1.45479628
42	MP0001970_abnormal_pain_threshold	1.45012753
43	MP0003787_abnormal_imprinting	1.43596118
44	MP0002572_abnormal_emotion/affect_behav	1.42611382
45	MP0001986_abnormal_taste_sensitivity	1.42280402
46	MP0004742_abnormal_vestibular_system	1.38549124
47	MP0003890_abnormal_embryonic-extraembry	1.36458703
48	MP0001440_abnormal_grooming_behavior	1.33423126
49	MP0003635_abnormal_synaptic_transmissio	1.33361921
50	MP0010386_abnormal_urinary_bladder	1.33240573
51	MP0002938_white_spotting	1.30875208
52	MP0002138_abnormal_hepatobiliary_system	1.28868656
53	MP0002557_abnormal_social/conspecific_i	1.28839167
54	MP0003878_abnormal_ear_physiology	1.28136239
55	MP0005377_hearing/vestibular/ear_phenot	1.28136239
56	MP0003880_abnormal_central_pattern	1.27760117
57	MP0000230_abnormal_systemic_arterial	1.24886319
58	MP0008775_abnormal_heart_ventricle	1.24727084
59	MP0002063_abnormal_learning/memory/cond	1.24016033
60	MP0002067_abnormal_sensory_capabilities	1.22542053
61	MP0002734_abnormal_mechanical_nocicepti	1.20991470
62	MP0004924_abnormal_behavior	1.18952988
63	MP0005386_behavior/neurological_phenoty	1.18952988
64	MP0000383_abnormal_hair_follicle	1.18517159
65	MP0005645_abnormal_hypothalamus_physiol	1.17133406
66	MP0002928_abnormal_bile_duct	1.15002791
67	MP0000026_abnormal_inner_ear	1.14722704
68	MP0000049_abnormal_middle_ear	1.12620149
69	MP0005195_abnormal_posterior_eye	1.09089418
70	MP0003119_abnormal_digestive_system	1.06988329
71	MP0000778_abnormal_nervous_system	1.06691755
72	MP0001963_abnormal_hearing_physiology	1.03889449
73	MP0004215_abnormal_myocardial_fiber	1.02604139
74	MP0002752_abnormal_somatic_nervous	1.02095955
75	MP0002163_abnormal_gland_morphology	1.01762301
76	MP0003937_abnormal_limbs/digits/tail_de	1.01146483
77	MP0008875_abnormal_xenobiotic_pharmacok	0.96709244
78	MP0002184_abnormal_innervation	0.96283099
79	MP0005448_abnormal_energy_balance	0.94973314
80	MP0008961_abnormal_basal_metabolism	0.93891574
81	MP0005410_abnormal_fertilization	0.93798031
82	MP0003137_abnormal_impulse_conducting	0.92465078
83	MP0002229_neurodegeneration	0.89759747
84	MP0004085_abnormal_heartbeat	0.89708953
85	MP0000538_abnormal_urinary_bladder	0.86181653
86	MP0005167_abnormal_blood-brain_barrier	0.83683463
87	MP0002234_abnormal_pharynx_morphology	0.83323345
88	MP0002882_abnormal_neuron_morphology	0.82254809
89	MP0003283_abnormal_digestive_organ	0.81420147
90	MP0005423_abnormal_somatic_nervous	0.81347700
91	MP0001919_abnormal_reproductive_system	0.79916380
92	MP0009250_abnormal_appendicular_skeleto	0.79561579
93	MP0001905_abnormal_dopamine_level	0.78092766
94	MP0000372_irregular_coat_pigmentation	0.76531213
95	MP0005670_abnormal_white_adipose	0.75631343
96	MP0000955_abnormal_spinal_cord	0.74046010
97	MP0000470_abnormal_stomach_morphology	0.73836543
98	MP0002095_abnormal_skin_pigmentation	0.73707686
99	MP0004147_increased_porphyrin_level	0.73325722
100	MP0001984_abnormal_olfaction	0.73060297

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	4.87635129
2	Pancreatic cysts (HP:0001737)	4.72478264
3	Progressive cerebellar ataxia (HP:0002073)	4.29180844
4	Pancreatic fibrosis (HP:0100732)	4.20679045
5	True hermaphroditism (HP:0010459)	4.01941479
6	Molar tooth sign on MRI (HP:0002419)	3.81678947
7	Abnormality of midbrain morphology (HP:0002418)	3.81678947
8	Congenital stationary night blindness (HP:0007642)	3.75675176
9	Nephronophthisis (HP:0000090)	3.62765484
10	Abolished electroretinogram (ERG) (HP:0000550)	3.29240856
11	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.27314836
12	Clumsiness (HP:0002312)	3.24355007
13	Hyperventilation (HP:0002883)	3.24197000
14	Gaze-evoked nystagmus (HP:0000640)	3.22900554
15	Decreased circulating renin level (HP:0003351)	3.20792163
16	Abnormality of the renal medulla (HP:0100957)	3.20093869
17	Cystic liver disease (HP:0006706)	3.10844054
18	Attenuation of retinal blood vessels (HP:0007843)	3.04092577
19	Pendular nystagmus (HP:0012043)	2.99609645
20	Abnormality of the renal cortex (HP:0011035)	2.94992400
21	Chronic hepatic failure (HP:0100626)	2.88193628
22	Congenital sensorineural hearing impairment (HP:0008527)	2.77185784
23	Tubular atrophy (HP:0000092)	2.70979163
24	Furrowed tongue (HP:0000221)	2.65392699
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.64660841
26	Protruding tongue (HP:0010808)	2.63517956
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.61465565
28	Abnormality of alanine metabolism (HP:0010916)	2.61465565
29	Hyperalaninemia (HP:0003348)	2.61465565
30	Type II lissencephaly (HP:0007260)	2.58629305
31	Keratoconus (HP:0000563)	2.57084128
32	Increased corneal curvature (HP:0100692)	2.57084128
33	Aplasia/Hypoplasia of the patella (HP:0006498)	2.57083632
34	Patellar aplasia (HP:0006443)	2.54426057
35	Decreased central vision (HP:0007663)	2.52703257
36	Chorioretinal atrophy (HP:0000533)	2.51038266
37	Congenital, generalized hypertrichosis (HP:0004540)	2.47193866
38	Sclerocornea (HP:0000647)	2.41066409
39	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.39536371
40	Medial flaring of the eyebrow (HP:0010747)	2.39178380
41	Inability to walk (HP:0002540)	2.36804758
42	Bony spicule pigmentary retinopathy (HP:0007737)	2.29396422
43	Agitation (HP:0000713)	2.28346302
44	Abnormality of the renal collecting system (HP:0004742)	2.26907828
45	Abnormal drinking behavior (HP:0030082)	2.26164532
46	Polydipsia (HP:0001959)	2.26164532
47	Anencephaly (HP:0002323)	2.25818111
48	Concave nail (HP:0001598)	2.25437002
49	Congenital hepatic fibrosis (HP:0002612)	2.22866791
50	Broad-based gait (HP:0002136)	2.22772353
51	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.20952545
52	Abnormality of binocular vision (HP:0011514)	2.19254997
53	Diplopia (HP:0000651)	2.19254997
54	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.19068625
55	Absent/shortened dynein arms (HP:0200106)	2.19068625
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15059944
57	Short tibia (HP:0005736)	2.13540050
58	Short 4th metacarpal (HP:0010044)	2.11676031
59	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.11676031
60	Small hand (HP:0200055)	2.09061824
61	Abnormal rod and cone electroretinograms (HP:0008323)	2.08316385
62	Large for gestational age (HP:0001520)	2.02765707
63	Male pseudohermaphroditism (HP:0000037)	2.00526165
64	Progressive inability to walk (HP:0002505)	1.99797784
65	Confusion (HP:0001289)	1.97642736
66	Hemiparesis (HP:0001269)	1.94674675
67	Hypoplasia of the pons (HP:0012110)	1.93191733
68	Short hallux (HP:0010109)	1.91775893
69	Birth length less than 3rd percentile (HP:0003561)	1.91162342
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.90114999
71	Abnormality of the pons (HP:0007361)	1.88809698
72	Abnormality of the nasal septum (HP:0000419)	1.88797599
73	Febrile seizures (HP:0002373)	1.88432176
74	Abnormal ciliary motility (HP:0012262)	1.87984869
75	Metabolic alkalosis (HP:0200114)	1.87704789
76	Impaired smooth pursuit (HP:0007772)	1.87603911
77	Gait imbalance (HP:0002141)	1.86392774
78	Asplenia (HP:0001746)	1.84957183
79	Fibular hypoplasia (HP:0003038)	1.84234944
80	Fair hair (HP:0002286)	1.83621370
81	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.83440308
82	Focal seizures (HP:0007359)	1.82876508
83	Hemiplegia (HP:0002301)	1.82043482
84	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.81200933
85	Cerebellar dysplasia (HP:0007033)	1.80423602
86	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.80044068
87	Congenital primary aphakia (HP:0007707)	1.78475207
88	Abnormality of renin-angiotensin system (HP:0000847)	1.77673128
89	Genital tract atresia (HP:0001827)	1.77547976
90	Absent speech (HP:0001344)	1.76114891
91	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.75732240
92	Vaginal atresia (HP:0000148)	1.75421744
93	Abnormality of the 4th metacarpal (HP:0010012)	1.74110166
94	Postaxial foot polydactyly (HP:0001830)	1.74086895
95	Mesomelia (HP:0003027)	1.74078959
96	Polyuria (HP:0000103)	1.73534455
97	Bile duct proliferation (HP:0001408)	1.72052927
98	Abnormal biliary tract physiology (HP:0012439)	1.72052927
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.71672931
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.71672931

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.19528044
2	ADRBK2	3.66899800
3	ACVR1B	3.46667038
4	BMPR1B	3.44795543
5	GRK1	2.63146282
6	TLK1	2.55633003
7	INSRR	2.42475363
8	WNK4	1.94637835
9	ZAK	1.90426272
10	PINK1	1.89411427
11	TAOK3	1.87063527
12	CASK	1.79595427
13	NUAK1	1.63982706
14	WNK3	1.60646512
15	MAP4K2	1.58475132
16	ADRBK1	1.54701943
17	MAPK13	1.53915842
18	NTRK3	1.46693139
19	DAPK2	1.38698067
20	OXSR1	1.32241480
21	STK39	1.20849568
22	TGFBR1	1.17628488
23	MAP3K4	1.12798519
24	MKNK2	1.11452209
25	PIK3CA	1.09798941
26	AKT3	1.09749667
27	CAMKK2	1.04588807
28	PRKCG	0.99678038
29	SGK2	0.99044735
30	TXK	0.96913631
31	MAPK15	0.95543106
32	SIK2	0.90797309
33	PTK2B	0.89913139
34	STK38L	0.89737707
35	TNIK	0.89502779
36	TIE1	0.87211759
37	PAK3	0.86704760
38	GRK7	0.83141296
39	PRKD2	0.82122002
40	PRKCE	0.78392719
41	SGK223	0.78364338
42	SGK494	0.78364338
43	CAMK1D	0.78315127
44	ERBB2	0.74962071
45	TEC	0.74767300
46	PNCK	0.73200085
47	MARK1	0.72049150
48	RPS6KA6	0.70135386
49	NTRK2	0.68855310
50	STK11	0.67663209
51	PIK3CG	0.66056304
52	DYRK2	0.64390443
53	IKBKB	0.63810586
54	PKN1	0.63228865
55	KIT	0.63009217
56	CAMK1	0.62202766
57	CAMK1G	0.61669973
58	MAP2K6	0.61267013
59	FGFR2	0.59716161
60	CAMK2A	0.59496445
61	PRKCH	0.58376278
62	NLK	0.56981042
63	PRKAA2	0.56639427
64	NEK2	0.55744992
65	OBSCN	0.55648904
66	PRKACA	0.53767828
67	STK3	0.52029552
68	PLK2	0.51580396
69	CHUK	0.51127925
70	MUSK	0.50662071
71	RPS6KA5	0.49541459
72	PHKG1	0.46794037
73	PHKG2	0.46794037
74	SGK1	0.45518076
75	TYRO3	0.44987176
76	PRKCQ	0.44122302
77	MAPKAPK5	0.42458890
78	MAPKAPK3	0.42400114
79	GRK5	0.41496130
80	WNK1	0.41027769
81	PRKCZ	0.41002348
82	PRKAA1	0.40779304
83	TNK2	0.40666396
84	CAMK4	0.40333691
85	CSNK1A1	0.40112428
86	IRAK1	0.39975520
87	BLK	0.39460243
88	CSNK1A1L	0.38537035
89	CSNK1G2	0.38282836
90	MAP3K7	0.37389247
91	CAMKK1	0.37227058
92	PRKCA	0.37046725
93	MAP2K7	0.36904171
94	ITK	0.35861466
95	MAP2K1	0.35291179
96	TRPM7	0.34589058
97	CSNK1D	0.34475167
98	LATS1	0.33788221
99	SYK	0.33260557
100	MELK	0.32093400

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.90157131
2	Phototransduction_Homo sapiens_hsa04744	2.89036960
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.50309917
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.43280392
5	Tryptophan metabolism_Homo sapiens_hsa00380	2.35793944
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.34760228
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.33155015
8	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.17573998
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.15027826
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.11262098
11	Morphine addiction_Homo sapiens_hsa05032	2.04504142
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.98251563
13	Butanoate metabolism_Homo sapiens_hsa00650	1.85371209
14	Taste transduction_Homo sapiens_hsa04742	1.83899375
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73361967
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.69040867
17	ABC transporters_Homo sapiens_hsa02010	1.63904830
18	Glutamatergic synapse_Homo sapiens_hsa04724	1.63013759
19	Olfactory transduction_Homo sapiens_hsa04740	1.62395012
20	Circadian entrainment_Homo sapiens_hsa04713	1.59304281
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.57698838
22	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.57502192
23	Homologous recombination_Homo sapiens_hsa03440	1.56766904
24	Serotonergic synapse_Homo sapiens_hsa04726	1.56051265
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.48362892
26	GABAergic synapse_Homo sapiens_hsa04727	1.47751164
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.42025877
28	Insulin secretion_Homo sapiens_hsa04911	1.36957536
29	Caffeine metabolism_Homo sapiens_hsa00232	1.34916022
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.33360139
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.31107423
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.31027084
33	Calcium signaling pathway_Homo sapiens_hsa04020	1.28597873
34	Retinol metabolism_Homo sapiens_hsa00830	1.27806945
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.27652774
36	Glycerolipid metabolism_Homo sapiens_hsa00561	1.26664393
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.20948990
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.14257882
39	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.14166650
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.14101355
41	Histidine metabolism_Homo sapiens_hsa00340	1.11833608
42	Cholinergic synapse_Homo sapiens_hsa04725	1.09706021
43	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.09495704
44	Fanconi anemia pathway_Homo sapiens_hsa03460	1.03323988
45	Salivary secretion_Homo sapiens_hsa04970	1.01922405
46	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.01458296
47	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.00774598
48	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.99833553
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91409498
50	Type II diabetes mellitus_Homo sapiens_hsa04930	0.91212111
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83212272
52	Basal transcription factors_Homo sapiens_hsa03022	0.82327443
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.81963838
54	cAMP signaling pathway_Homo sapiens_hsa04024	0.81600888
55	RNA polymerase_Homo sapiens_hsa03020	0.80513591
56	Dopaminergic synapse_Homo sapiens_hsa04728	0.80014933
57	Gastric acid secretion_Homo sapiens_hsa04971	0.77309378
58	Oxidative phosphorylation_Homo sapiens_hsa00190	0.73939623
59	Long-term depression_Homo sapiens_hsa04730	0.73540530
60	Sulfur relay system_Homo sapiens_hsa04122	0.73427305
61	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.72600913
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71331413
63	Asthma_Homo sapiens_hsa05310	0.71114404
64	Peroxisome_Homo sapiens_hsa04146	0.70498287
65	Cocaine addiction_Homo sapiens_hsa05030	0.68054495
66	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.66991514
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66975360
68	Renin secretion_Homo sapiens_hsa04924	0.65828645
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.65043689
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.62428726
71	Melanoma_Homo sapiens_hsa05218	0.59978832
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.59586586
73	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.57949234
74	Graft-versus-host disease_Homo sapiens_hsa05332	0.54873315
75	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.51540410
76	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51503935
77	Sulfur metabolism_Homo sapiens_hsa00920	0.50774016
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50062966
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49063579
80	MAPK signaling pathway_Homo sapiens_hsa04010	0.48652667
81	Ras signaling pathway_Homo sapiens_hsa04014	0.47492690
82	Mineral absorption_Homo sapiens_hsa04978	0.47382756
83	Amphetamine addiction_Homo sapiens_hsa05031	0.47339398
84	Basal cell carcinoma_Homo sapiens_hsa05217	0.43591039
85	Pancreatic secretion_Homo sapiens_hsa04972	0.43264859
86	RNA degradation_Homo sapiens_hsa03018	0.42404890
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.42193659
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42040974
89	Huntingtons disease_Homo sapiens_hsa05016	0.41406073
90	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.38433882
91	One carbon pool by folate_Homo sapiens_hsa00670	0.38430028
92	Alzheimers disease_Homo sapiens_hsa05010	0.38272236
93	Axon guidance_Homo sapiens_hsa04360	0.37723027
94	Parkinsons disease_Homo sapiens_hsa05012	0.37021722
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36920372
96	Regulation of autophagy_Homo sapiens_hsa04140	0.35521035
97	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.35461687
98	Bile secretion_Homo sapiens_hsa04976	0.34790298
99	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.34558675
100	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.30991996

HNRNPA1P54

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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