HNRNPA1P56

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)5.76781279
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.88291423
3DNA deamination (GO:0045006)4.87450626
4proteasome assembly (GO:0043248)4.63236531
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.38833874
6ATP synthesis coupled proton transport (GO:0015986)4.38833874
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.34761355
8pseudouridine synthesis (GO:0001522)4.24055058
9RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.14422667
10tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.14422667
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.96187532
12base-excision repair, AP site formation (GO:0006285)3.91547287
13kinetochore assembly (GO:0051382)3.88549967
14protein deneddylation (GO:0000338)3.86758890
15exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.75354319
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.72124445
17water-soluble vitamin biosynthetic process (GO:0042364)3.71989620
18negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.66250318
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.64091803
20NADH dehydrogenase complex assembly (GO:0010257)3.64091803
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64091803
22cullin deneddylation (GO:0010388)3.58323568
23protein complex biogenesis (GO:0070271)3.55158764
24protein neddylation (GO:0045116)3.48419232
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45950088
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44864283
27inner mitochondrial membrane organization (GO:0007007)3.43499887
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.42750494
29termination of RNA polymerase III transcription (GO:0006386)3.42750494
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.38755770
31respiratory chain complex IV assembly (GO:0008535)3.36229457
32mitochondrial respiratory chain complex assembly (GO:0033108)3.33715641
33regulation of chronic inflammatory response (GO:0002676)3.29641243
34kinetochore organization (GO:0051383)3.27753171
35rRNA modification (GO:0000154)3.14325729
36metaphase plate congression (GO:0051310)3.13875414
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13844753
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13844753
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13844753
40DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.13526576
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.13307964
42negative regulation of ligase activity (GO:0051352)3.07249498
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07249498
44regulation of cellular amino acid metabolic process (GO:0006521)3.06032296
45somatic hypermutation of immunoglobulin genes (GO:0016446)3.05230359
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05230359
47intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.03639643
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.03639643
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02416463
50signal transduction involved in DNA damage checkpoint (GO:0072422)3.02416463
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.99934695
52signal transduction involved in cell cycle checkpoint (GO:0072395)2.99503212
53RNA destabilization (GO:0050779)2.99352247
54CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.98074703
55GTP biosynthetic process (GO:0006183)2.97724948
56nucleotide transmembrane transport (GO:1901679)2.97684440
57aldehyde catabolic process (GO:0046185)2.96360997
58termination of RNA polymerase I transcription (GO:0006363)2.95368957
59RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.93790376
60transcription elongation from RNA polymerase I promoter (GO:0006362)2.93621411
61positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92150912
62ribosome assembly (GO:0042255)2.91206872
63protein K6-linked ubiquitination (GO:0085020)2.88832526
64negative regulation of DNA-templated transcription, elongation (GO:0032785)2.88478686
65negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87216114
66positive regulation of ligase activity (GO:0051351)2.85682293
67DNA double-strand break processing (GO:0000729)2.83976111
68protein-cofactor linkage (GO:0018065)2.83286573
69positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.82619462
70somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82456771
71isotype switching (GO:0045190)2.82456771
72somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82456771
73replication fork processing (GO:0031297)2.82448257
74mitotic metaphase plate congression (GO:0007080)2.82437915
75tRNA processing (GO:0008033)2.80041285
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.80038491
77regulation of mitotic spindle checkpoint (GO:1903504)2.80038491
78rRNA catabolic process (GO:0016075)2.79978214
79DNA catabolic process, exonucleolytic (GO:0000738)2.78536967
80protein targeting to mitochondrion (GO:0006626)2.76995577
81chromatin remodeling at centromere (GO:0031055)2.76737147
82cytochrome complex assembly (GO:0017004)2.76653973
83positive regulation of prostaglandin secretion (GO:0032308)2.76380807
84ribosomal small subunit assembly (GO:0000028)2.76184905
85CENP-A containing nucleosome assembly (GO:0034080)2.75516419
86DNA damage response, detection of DNA damage (GO:0042769)2.74000850
87maturation of SSU-rRNA (GO:0030490)2.72080459
88respiratory electron transport chain (GO:0022904)2.71693528
89transcription from RNA polymerase I promoter (GO:0006360)2.69497363
90electron transport chain (GO:0022900)2.69282443
91AMP metabolic process (GO:0046033)2.67552406
92regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.66582328
93purine nucleoside triphosphate biosynthetic process (GO:0009145)2.66481664
94negative regulation of alpha-beta T cell differentiation (GO:0046639)2.66298334
95adenosine metabolic process (GO:0046085)2.63352688
96regulation of meiosis I (GO:0060631)2.62946466
97tRNA metabolic process (GO:0006399)2.62525145
98rRNA methylation (GO:0031167)2.62054239
99purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.61735844
100interferon-gamma production (GO:0032609)2.61703271

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.06240231
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.63104318
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.22689301
4ELF1_17652178_ChIP-ChIP_JURKAT_Human4.04599752
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.25655916
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.25223768
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23372917
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.18154509
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.95849325
10VDR_23849224_ChIP-Seq_CD4+_Human2.80218657
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69631369
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68908099
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59615834
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50940112
15ELK1_19687146_ChIP-ChIP_HELA_Human2.50258471
16ZNF274_21170338_ChIP-Seq_K562_Hela2.45303725
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35256520
18FOXP3_21729870_ChIP-Seq_TREG_Human2.34916881
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23584938
20VDR_22108803_ChIP-Seq_LS180_Human2.23201606
21MYC_18940864_ChIP-ChIP_HL60_Human2.13882751
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12441462
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.08034150
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07817679
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.06514911
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.01557141
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.99970395
28EWS_26573619_Chip-Seq_HEK293_Human1.99120311
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71694424
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69788414
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59293876
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59110232
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56374682
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55297007
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49817269
36FUS_26573619_Chip-Seq_HEK293_Human1.44414828
37GABP_19822575_ChIP-Seq_HepG2_Human1.44309762
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.40525357
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40319494
40IRF1_19129219_ChIP-ChIP_H3396_Human1.35090777
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34991911
42TTF2_22483619_ChIP-Seq_HELA_Human1.34401615
43DCP1A_22483619_ChIP-Seq_HELA_Human1.33459713
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29773108
45XRN2_22483619_ChIP-Seq_HELA_Human1.29205104
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.29140796
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28693356
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28210944
49AR_20517297_ChIP-Seq_VCAP_Human1.26239769
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.24955211
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23417908
52TP53_22573176_ChIP-Seq_HFKS_Human1.23214410
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22480970
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22182353
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21136351
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20790857
57GATA3_26560356_Chip-Seq_TH2_Human1.20224462
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19006987
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17043156
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16982916
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16813098
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16126522
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.14783029
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14783029
65ER_23166858_ChIP-Seq_MCF-7_Human1.13925444
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13913782
67NCOR_22424771_ChIP-Seq_293T_Human1.13344637
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.13146066
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12299145
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10921430
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10530427
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08144662
73TAF15_26573619_Chip-Seq_HEK293_Human1.06290420
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04367846
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03133194
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01539771
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01078537
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98967284
79P300_19829295_ChIP-Seq_ESCs_Human0.98109789
80EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96467893
81CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95780548
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94195003
83CBP_20019798_ChIP-Seq_JUKART_Human0.94195003
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93745145
85NANOG_19829295_ChIP-Seq_ESCs_Human0.91172072
86SOX2_19829295_ChIP-Seq_ESCs_Human0.91172072
87HOXB7_26014856_ChIP-Seq_BT474_Human0.90343174
88CIITA_25753668_ChIP-Seq_RAJI_Human0.90289457
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88335589
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88243115
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88087689
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.87456636
93IRF8_21731497_ChIP-ChIP_J774_Mouse0.87241072
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86081396
95NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86033593
96TDRD3_21172665_ChIP-Seq_MCF-7_Human0.85937821
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85789591
98NANOG_20526341_ChIP-Seq_ESCs_Human0.85514875
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82572018
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81948365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.88664071
2MP0008877_abnormal_DNA_methylation3.76048187
3MP0001348_abnormal_lacrimal_gland2.87384136
4MP0002102_abnormal_ear_morphology2.70122354
5MP0003693_abnormal_embryo_hatching2.52104325
6MP0008875_abnormal_xenobiotic_pharmacok2.47867928
7MP0008872_abnormal_physiological_respon2.46748587
8MP0003806_abnormal_nucleotide_metabolis2.41418305
9MP0001986_abnormal_taste_sensitivity2.29519569
10MP0002736_abnormal_nociception_after2.25156918
11MP0002837_dystrophic_cardiac_calcinosis2.20741171
12MP0005671_abnormal_response_to2.16677211
13MP0001835_abnormal_antigen_presentation2.12627707
14MP0006072_abnormal_retinal_apoptosis2.05177460
15MP0003786_premature_aging1.91375352
16MP0010094_abnormal_chromosome_stability1.91305049
17MP0005646_abnormal_pituitary_gland1.77459041
18MP0003077_abnormal_cell_cycle1.77165901
19MP0003283_abnormal_digestive_organ1.75014000
20MP0002163_abnormal_gland_morphology1.73974857
21MP0003111_abnormal_nucleus_morphology1.72357750
22MP0001968_abnormal_touch/_nociception1.70008160
23MP0003718_maternal_effect1.65224452
24MP0005423_abnormal_somatic_nervous1.63294556
25MP0004957_abnormal_blastocyst_morpholog1.61335047
26MP0002006_tumorigenesis1.59564009
27MP0003011_delayed_dark_adaptation1.57984862
28MP0001984_abnormal_olfaction1.56968221
29MP0003195_calcinosis1.54274252
30MP0000566_synostosis1.48168920
31MP0005084_abnormal_gallbladder_morpholo1.42164924
32MP0006292_abnormal_olfactory_placode1.38656123
33MP0000427_abnormal_hair_cycle1.38489858
34MP0005551_abnormal_eye_electrophysiolog1.37578687
35MP0005379_endocrine/exocrine_gland_phen1.37249154
36MP0000685_abnormal_immune_system1.32491464
37MP0003186_abnormal_redox_activity1.31633630
38MP0005310_abnormal_salivary_gland1.30079150
39MP0006036_abnormal_mitochondrial_physio1.29475941
40MP0001764_abnormal_homeostasis1.28038127
41MP0004145_abnormal_muscle_electrophysio1.26815697
42MP0001800_abnormal_humoral_immune1.23818697
43MP0000372_irregular_coat_pigmentation1.21143501
44MP0001293_anophthalmia1.16838209
45MP0005389_reproductive_system_phenotype1.16586064
46MP0002160_abnormal_reproductive_system1.14142881
47MP0003045_fibrosis1.13781430
48MP0009785_altered_susceptibility_to1.08702473
49MP0002148_abnormal_hypersensitivity_rea1.08587214
50MP0009333_abnormal_splenocyte_physiolog1.07881392
51MP0004142_abnormal_muscle_tone1.07717559
52MP0000383_abnormal_hair_follicle1.07322918
53MP0009745_abnormal_behavioral_response1.06452663
54MP0001873_stomach_inflammation1.06356320
55MP0002166_altered_tumor_susceptibility1.05655132
56MP0001929_abnormal_gametogenesis1.05460783
57MP0008995_early_reproductive_senescence1.02322892
58MP0002876_abnormal_thyroid_physiology1.01842574
59MP0003646_muscle_fatigue1.00658950
60MP0002938_white_spotting1.00433766
61MP0001919_abnormal_reproductive_system0.99543525
62MP0005000_abnormal_immune_tolerance0.98878590
63MP0004215_abnormal_myocardial_fiber0.98348566
64MP0000613_abnormal_salivary_gland0.97117704
65MP0003763_abnormal_thymus_physiology0.93790250
66MP0002723_abnormal_immune_serum0.93411426
67MP0008775_abnormal_heart_ventricle0.93063975
68MP0002210_abnormal_sex_determination0.92501385
69MP0005253_abnormal_eye_physiology0.91314534
70MP0008007_abnormal_cellular_replicative0.90715092
71MP0002277_abnormal_respiratory_mucosa0.89921183
72MP0001529_abnormal_vocalization0.88340948
73MP0002272_abnormal_nervous_system0.86566622
74MP0000569_abnormal_digit_pigmentation0.86536337
75MP0001905_abnormal_dopamine_level0.85548720
76MP0005395_other_phenotype0.82820321
77MP0003567_abnormal_fetal_cardiomyocyte0.81575167
78MP0008932_abnormal_embryonic_tissue0.81247742
79MP0001119_abnormal_female_reproductive0.80846485
80MP0000653_abnormal_sex_gland0.80343940
81MP0002452_abnormal_antigen_presenting0.80131037
82MP0004134_abnormal_chest_morphology0.79499598
83MP0006035_abnormal_mitochondrial_morpho0.78798567
84MP0003787_abnormal_imprinting0.78700577
85MP0001486_abnormal_startle_reflex0.78618323
86MP0002234_abnormal_pharynx_morphology0.78046588
87MP0001145_abnormal_male_reproductive0.77968909
88MP0004133_heterotaxia0.75931458
89MP0003938_abnormal_ear_development0.75623730
90MP0001819_abnormal_immune_cell0.74895374
91MP0002420_abnormal_adaptive_immunity0.74185568
92MP0003698_abnormal_male_reproductive0.74101496
93MP0001440_abnormal_grooming_behavior0.72803415
94MP0004043_abnormal_pH_regulation0.72391308
95MP0001485_abnormal_pinna_reflex0.72127613
96MP0002733_abnormal_thermal_nociception0.70818989
97MP0005387_immune_system_phenotype0.70354915
98MP0001790_abnormal_immune_system0.70354915
99MP0002138_abnormal_hepatobiliary_system0.69509616
100MP0006082_CNS_inflammation0.69476989

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.04710728
2Acute encephalopathy (HP:0006846)3.85093379
3Progressive macrocephaly (HP:0004481)3.69352862
4Lipid accumulation in hepatocytes (HP:0006561)3.64328917
5Increased CSF lactate (HP:0002490)3.58323421
6Mitochondrial inheritance (HP:0001427)3.57428633
7Increased hepatocellular lipid droplets (HP:0006565)3.49238148
8Abnormal mitochondria in muscle tissue (HP:0008316)3.46804986
9Abnormal number of erythroid precursors (HP:0012131)3.19032293
103-Methylglutaconic aciduria (HP:0003535)3.14767533
11Hepatocellular necrosis (HP:0001404)3.11297219
12Congenital stationary night blindness (HP:0007642)3.10821151
13Renal Fanconi syndrome (HP:0001994)3.07315966
14Pancreatic cysts (HP:0001737)3.04580548
15Parakeratosis (HP:0001036)2.81757278
16Hepatic necrosis (HP:0002605)2.79086515
17Progressive microcephaly (HP:0000253)2.77589105
18Colon cancer (HP:0003003)2.72470331
19Abnormality of cells of the erythroid lineage (HP:0012130)2.70478534
20Increased serum lactate (HP:0002151)2.69667646
21IgG deficiency (HP:0004315)2.63074598
22Hyperglycinemia (HP:0002154)2.59051998
23Bilateral microphthalmos (HP:0007633)2.58456975
24Exertional dyspnea (HP:0002875)2.56629773
25Abnormality of the labia minora (HP:0012880)2.56565997
26Increased serum pyruvate (HP:0003542)2.56320364
27Cerebral edema (HP:0002181)2.54976579
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50566170
29Hyperglycinuria (HP:0003108)2.49632510
30Pancreatic fibrosis (HP:0100732)2.45755390
31Methylmalonic acidemia (HP:0002912)2.41600561
32Type I transferrin isoform profile (HP:0003642)2.40775695
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.37025164
34Lactic acidosis (HP:0003128)2.33933992
35Optic disc pallor (HP:0000543)2.33897191
36Inability to walk (HP:0002540)2.30256410
37True hermaphroditism (HP:0010459)2.28706000
38Aplasia/hypoplasia of the uterus (HP:0008684)2.27420917
39Meckel diverticulum (HP:0002245)2.27025054
40Pendular nystagmus (HP:0012043)2.25733427
41Abnormality of the ileum (HP:0001549)2.24578205
42Cerebral hypomyelination (HP:0006808)2.22014359
43Progressive inability to walk (HP:0002505)2.17382190
44Lethargy (HP:0001254)2.17241615
45Abnormality of glycine metabolism (HP:0010895)2.16946004
46Abnormality of serine family amino acid metabolism (HP:0010894)2.16946004
47Hypoplasia of the uterus (HP:0000013)2.14919165
48Congenital, generalized hypertrichosis (HP:0004540)2.11330856
49Abnormal protein glycosylation (HP:0012346)2.10077334
50Abnormal glycosylation (HP:0012345)2.10077334
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10077334
52Abnormal protein N-linked glycosylation (HP:0012347)2.10077334
53Abnormality of alanine metabolism (HP:0010916)2.09271305
54Hyperalaninemia (HP:0003348)2.09271305
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09271305
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.05598141
57Fibular aplasia (HP:0002990)2.04781365
58Amaurosis fugax (HP:0100576)2.03407405
59Respiratory failure (HP:0002878)2.02309392
60Abolished electroretinogram (ERG) (HP:0000550)2.02053098
61Absent thumb (HP:0009777)2.01701474
62Hypothermia (HP:0002045)2.00599506
63Abnormality of glycolysis (HP:0004366)2.00037525
64Abnormality of the pons (HP:0007361)1.99021613
65Methylmalonic aciduria (HP:0012120)1.97235724
66Hypoplasia of the pons (HP:0012110)1.95658324
67Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94614638
68Abnormality of the renal cortex (HP:0011035)1.94499114
69Hypoproteinemia (HP:0003075)1.92538380
70Leukodystrophy (HP:0002415)1.91953795
71Abnormality of placental membranes (HP:0011409)1.90980870
72Amniotic constriction ring (HP:0009775)1.90980870
73Abnormality of macular pigmentation (HP:0008002)1.87446642
74Increased intramyocellular lipid droplets (HP:0012240)1.87195293
75Duodenal stenosis (HP:0100867)1.85400328
76Small intestinal stenosis (HP:0012848)1.85400328
77Abnormality of the anterior horn cell (HP:0006802)1.84143837
78Degeneration of anterior horn cells (HP:0002398)1.84143837
79Exercise intolerance (HP:0003546)1.83514279
80Cleft eyelid (HP:0000625)1.83375912
81Triphalangeal thumb (HP:0001199)1.83111249
82Respiratory difficulties (HP:0002880)1.81976881
83Renal cortical cysts (HP:0000803)1.81929998
84Nephronophthisis (HP:0000090)1.79290058
85Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78816323
86Abnormality of the preputium (HP:0100587)1.77869979
87Abnormality of renal resorption (HP:0011038)1.77807633
88Hypochromic microcytic anemia (HP:0004840)1.77728039
89Abnormal drinking behavior (HP:0030082)1.77433847
90Polydipsia (HP:0001959)1.77433847
91Increased muscle lipid content (HP:0009058)1.76929696
92Retrobulbar optic neuritis (HP:0100654)1.76548187
93Optic neuritis (HP:0100653)1.76548187
94CNS hypomyelination (HP:0003429)1.76297356
95Abnormality of serum amino acid levels (HP:0003112)1.75813603
96CNS demyelination (HP:0007305)1.74989340
97Hyperphosphaturia (HP:0003109)1.74700315
98Clubbing of toes (HP:0100760)1.73696647
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.73580764
100Anorexia (HP:0002039)1.72538776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.84815260
2MAP4K23.77761813
3MST43.53308623
4ZAK3.47492122
5TXK3.05639796
6TLK12.80792534
7BUB12.79223551
8PBK2.77052938
9NUAK12.65137322
10FRK2.52876670
11TSSK62.44796523
12SRPK12.36812552
13EIF2AK12.31720679
14EIF2AK32.27494037
15PLK32.08087091
16NEK11.94046721
17PINK11.82027237
18ADRBK21.80784684
19VRK11.79323580
20TAOK31.78061799
21TRIM281.76701544
22PLK41.62174116
23BCKDK1.45098793
24OXSR11.45011714
25GRK11.44463706
26EIF2AK21.42616952
27TAF11.32547331
28PHKG21.31838109
29PHKG11.31838109
30MAPKAPK31.30442604
31WNK41.29870174
32MAP3K41.24026323
33STK161.20763922
34MKNK11.20365586
35NME11.09153646
36CDC71.08680294
37MUSK1.05309049
38BMPR1B1.03515903
39STK390.99777229
40TTK0.99167290
41MKNK20.97703799
42WNK30.96344579
43PLK10.94642294
44PLK20.94469326
45DAPK10.92927856
46NEK90.87073854
47GRK60.81822060
48FES0.80839931
49PDK20.79738052
50AURKB0.71915735
51PASK0.69118784
52TESK20.64611005
53IKBKB0.64293829
54PRKCQ0.62932890
55STK40.59871049
56NEK20.59783683
57DYRK20.58502423
58ATR0.57557249
59CSNK1G10.53883049
60TNIK0.53811313
61GRK50.52944358
62CDK190.51884416
63CSNK1G30.51632010
64CCNB10.51479655
65IKBKE0.50536509
66STK30.49947710
67INSRR0.47736120
68WEE10.47387169
69PRKCG0.47319257
70PRKCI0.44464469
71ADRBK10.44416537
72ERBB30.44212049
73FGFR20.43510979
74IRAK40.42825667
75ALK0.42489822
76CHEK20.39535224
77ITK0.38166930
78TGFBR10.37975327
79STK100.36351001
80CSNK2A10.35716786
81DYRK30.35646670
82CSNK2A20.35152262
83RPS6KA50.34653801
84TBK10.33274738
85KIT0.33232541
86TNK20.33057470
87CSNK1G20.32244695
88AURKA0.30337450
89MAPK130.29340840
90LCK0.28620468
91PRKCE0.27252509
92STK38L0.26812221
93RPS6KA40.25896651
94CSNK1A10.25243755
95PIK3CG0.24918806
96ABL10.24748731
97NME20.24370673
98LYN0.22780895
99TIE10.22689133
100SYK0.22412862

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.26259831
2RNA polymerase_Homo sapiens_hsa030203.09446574
3Ribosome_Homo sapiens_hsa030102.84879045
4Oxidative phosphorylation_Homo sapiens_hsa001902.73309386
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50589539
6Homologous recombination_Homo sapiens_hsa034402.43280467
7Parkinsons disease_Homo sapiens_hsa050122.41853310
8Protein export_Homo sapiens_hsa030602.33241945
9Asthma_Homo sapiens_hsa053102.23910850
10Non-homologous end-joining_Homo sapiens_hsa034502.17527374
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11483321
12RNA degradation_Homo sapiens_hsa030181.95710351
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.92808617
14Fanconi anemia pathway_Homo sapiens_hsa034601.91419278
15Basal transcription factors_Homo sapiens_hsa030221.89421992
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84131499
17Base excision repair_Homo sapiens_hsa034101.80517228
18Allograft rejection_Homo sapiens_hsa053301.73025355
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71915366
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65362062
21Autoimmune thyroid disease_Homo sapiens_hsa053201.64621049
22Mismatch repair_Homo sapiens_hsa034301.61731875
23Huntingtons disease_Homo sapiens_hsa050161.59199185
24RNA transport_Homo sapiens_hsa030131.58674377
25One carbon pool by folate_Homo sapiens_hsa006701.55847306
26Alzheimers disease_Homo sapiens_hsa050101.52371303
27Spliceosome_Homo sapiens_hsa030401.49755946
28Propanoate metabolism_Homo sapiens_hsa006401.48899498
29Purine metabolism_Homo sapiens_hsa002301.47694277
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46176010
31DNA replication_Homo sapiens_hsa030301.44924196
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44195285
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43445156
34Linoleic acid metabolism_Homo sapiens_hsa005911.40515484
35Nucleotide excision repair_Homo sapiens_hsa034201.37695348
36Pyrimidine metabolism_Homo sapiens_hsa002401.35901270
37Phototransduction_Homo sapiens_hsa047441.35294518
38Sulfur metabolism_Homo sapiens_hsa009201.28686624
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23653625
40Primary immunodeficiency_Homo sapiens_hsa053401.21499417
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20675560
42Graft-versus-host disease_Homo sapiens_hsa053321.20151779
43Caffeine metabolism_Homo sapiens_hsa002321.18821431
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18519320
45Peroxisome_Homo sapiens_hsa041461.14581476
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09544505
47Butanoate metabolism_Homo sapiens_hsa006501.08769951
48Type I diabetes mellitus_Homo sapiens_hsa049401.04938301
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02529879
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00848980
51Selenocompound metabolism_Homo sapiens_hsa004501.00011758
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98875947
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.97929669
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94123138
55Antigen processing and presentation_Homo sapiens_hsa046120.93914976
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91503646
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80865963
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78972776
59Fatty acid elongation_Homo sapiens_hsa000620.73684341
60Tryptophan metabolism_Homo sapiens_hsa003800.73576538
61Cardiac muscle contraction_Homo sapiens_hsa042600.72509192
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70292800
63Vitamin B6 metabolism_Homo sapiens_hsa007500.69558034
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67309029
65Metabolic pathways_Homo sapiens_hsa011000.67063526
66Nitrogen metabolism_Homo sapiens_hsa009100.65765377
67p53 signaling pathway_Homo sapiens_hsa041150.64915648
68Retinol metabolism_Homo sapiens_hsa008300.63267667
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63072965
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60938151
71Arachidonic acid metabolism_Homo sapiens_hsa005900.58795705
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57767465
73Fat digestion and absorption_Homo sapiens_hsa049750.52600303
74Chemical carcinogenesis_Homo sapiens_hsa052040.52056476
75Pyruvate metabolism_Homo sapiens_hsa006200.47182120
76Olfactory transduction_Homo sapiens_hsa047400.45202327
77Ether lipid metabolism_Homo sapiens_hsa005650.44400506
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43729034
79Oocyte meiosis_Homo sapiens_hsa041140.40539847
80Carbon metabolism_Homo sapiens_hsa012000.38299982
81Hematopoietic cell lineage_Homo sapiens_hsa046400.38154603
82Nicotine addiction_Homo sapiens_hsa050330.38065045
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37294085
84Regulation of autophagy_Homo sapiens_hsa041400.35693633
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.35078929
86Morphine addiction_Homo sapiens_hsa050320.34413521
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.32202688
88N-Glycan biosynthesis_Homo sapiens_hsa005100.29582012
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.27348502
90Tyrosine metabolism_Homo sapiens_hsa003500.26797479
91Biosynthesis of amino acids_Homo sapiens_hsa012300.26788942
92Glycerolipid metabolism_Homo sapiens_hsa005610.26594003
93Cell cycle_Homo sapiens_hsa041100.26428836
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.25823511
95ABC transporters_Homo sapiens_hsa020100.25820999
96Rheumatoid arthritis_Homo sapiens_hsa053230.25751058
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24690340
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24146902
99Herpes simplex infection_Homo sapiens_hsa051680.23548060
100Fatty acid metabolism_Homo sapiens_hsa012120.23295034

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