ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.11768541
2	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.99252153
3	rRNA modification (GO:0000154)	4.65594805
4	regulation of isotype switching to IgG isotypes (GO:0048302)	4.47661239
5	proteasome assembly (GO:0043248)	4.40896898
6	maturation of SSU-rRNA (GO:0030490)	4.37794652
7	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.35362674
8	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.33919449
9	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.29555896
10	rRNA methylation (GO:0031167)	4.16963802
11	L-fucose metabolic process (GO:0042354)	4.07200389
12	L-fucose catabolic process (GO:0042355)	4.07200389
13	fucose catabolic process (GO:0019317)	4.07200389
14	ATP synthesis coupled proton transport (GO:0015986)	4.04084961
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.04084961
16	regulation of immunoglobulin secretion (GO:0051023)	4.03310810
17	chaperone-mediated protein transport (GO:0072321)	3.95558151
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.94925660
19	cullin deneddylation (GO:0010388)	3.93396455
20	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.70264630
21	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.68200465
22	protein deneddylation (GO:0000338)	3.57641641
23	regulation of podosome assembly (GO:0071801)	3.55901065
24	regulation of cellular amino acid metabolic process (GO:0006521)	3.55853263
25	protein neddylation (GO:0045116)	3.48237961
26	negative regulation of B cell apoptotic process (GO:0002903)	3.40368855
27	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.39922407
28	positive regulation of isotype switching (GO:0045830)	3.38924362
29	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.37700992
30	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.36605235
31	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.36605235
32	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.36605235
33	water-soluble vitamin biosynthetic process (GO:0042364)	3.36343288
34	purine-containing compound salvage (GO:0043101)	3.34843422
35	regulation of chronic inflammatory response (GO:0002676)	3.33826040
36	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.31302590
37	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.31302590
38	DNA catabolic process, exonucleolytic (GO:0000738)	3.30320305
39	L-methionine salvage (GO:0071267)	3.29097843
40	L-methionine biosynthetic process (GO:0071265)	3.29097843
41	amino acid salvage (GO:0043102)	3.29097843
42	platelet dense granule organization (GO:0060155)	3.28321864
43	negative regulation of ligase activity (GO:0051352)	3.27745303
44	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.27745303
45	pseudouridine synthesis (GO:0001522)	3.27630798
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.27200263
47	NADH dehydrogenase complex assembly (GO:0010257)	3.27200263
48	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.27200263
49	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.26785165
50	rRNA processing (GO:0006364)	3.21793437
51	ribosomal large subunit biogenesis (GO:0042273)	3.21282592
52	protein complex biogenesis (GO:0070271)	3.20630361
53	ribosomal small subunit assembly (GO:0000028)	3.19831236
54	rRNA metabolic process (GO:0016072)	3.17066013
55	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.16705404
56	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.16705404
57	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.14929107
58	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.12182438
59	mitochondrial respiratory chain complex assembly (GO:0033108)	3.11427648
60	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.10491586
61	termination of RNA polymerase III transcription (GO:0006386)	3.10491586
62	ribosome biogenesis (GO:0042254)	3.09752731
63	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.09513379
64	positive regulation of DNA recombination (GO:0045911)	3.05677625
65	activated T cell proliferation (GO:0050798)	3.04794440
66	IMP biosynthetic process (GO:0006188)	3.04011345
67	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.03464446
68	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.02743952
69	tRNA processing (GO:0008033)	3.02305113
70	purine nucleobase biosynthetic process (GO:0009113)	3.00664295
71	protein-cofactor linkage (GO:0018065)	2.98342396
72	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.95163838
73	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.95163838
74	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.88247570
75	negative regulation of mast cell activation (GO:0033004)	2.87073963
76	purine nucleotide salvage (GO:0032261)	2.85867921
77	methionine biosynthetic process (GO:0009086)	2.84722278
78	cellular component biogenesis (GO:0044085)	2.80703007
79	ribonucleoprotein complex biogenesis (GO:0022613)	2.79967771
80	respiratory electron transport chain (GO:0022904)	2.79009923
81	electron transport chain (GO:0022900)	2.78321231
82	DNA double-strand break processing (GO:0000729)	2.77674463
83	respiratory chain complex IV assembly (GO:0008535)	2.77564026
84	tRNA metabolic process (GO:0006399)	2.77463971
85	positive regulation of immunoglobulin production (GO:0002639)	2.77218541
86	positive regulation of ligase activity (GO:0051351)	2.76508798
87	7-methylguanosine mRNA capping (GO:0006370)	2.76093861
88	ncRNA processing (GO:0034470)	2.74653219
89	nucleobase biosynthetic process (GO:0046112)	2.72882649
90	amino acid activation (GO:0043038)	2.72338770
91	tRNA aminoacylation (GO:0043039)	2.72338770
92	mast cell activation involved in immune response (GO:0002279)	2.72141298
93	mast cell degranulation (GO:0043303)	2.72141298
94	tRNA modification (GO:0006400)	2.71717256
95	ncRNA metabolic process (GO:0034660)	2.70826714
96	RNA capping (GO:0036260)	2.69223648
97	7-methylguanosine RNA capping (GO:0009452)	2.69223648
98	ribosome assembly (GO:0042255)	2.69211182
99	translation (GO:0006412)	2.68895948
100	GTP biosynthetic process (GO:0006183)	2.68820108

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.20476146
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.78634386
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.94557664
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.65951077
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.50739397
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.47429496
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.33485768
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.18240853
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.17754741
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.87503362
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.80765679
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.76038075
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.73857488
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.73507342
15	FOXP3_21729870_ChIP-Seq_TREG_Human	2.55760829
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.54818752
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.33435641
18	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.31404710
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.22139863
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.08739291
21	ZNF274_21170338_ChIP-Seq_K562_Hela	2.00983315
22	VDR_22108803_ChIP-Seq_LS180_Human	1.99187481
23	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.99001185
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.98998231
25	DCP1A_22483619_ChIP-Seq_HELA_Human	1.97428139
26	EWS_26573619_Chip-Seq_HEK293_Human	1.93232594
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.93083325
28	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.91015380
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.90359856
30	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.87774069
31	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.85110189
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.81835218
33	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.81454299
34	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.78022826
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.76582536
36	TTF2_22483619_ChIP-Seq_HELA_Human	1.72367452
37	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.71756862
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68099338
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.64518867
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.62732184
41	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.62588339
42	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.57294862
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.55763202
44	FUS_26573619_Chip-Seq_HEK293_Human	1.55355063
45	XRN2_22483619_ChIP-Seq_HELA_Human	1.51755495
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.49685446
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46553821
48	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.46073172
49	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.44310301
50	GABP_19822575_ChIP-Seq_HepG2_Human	1.41683872
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37791376
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34803385
53	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.34630203
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.31104717
55	TAF15_26573619_Chip-Seq_HEK293_Human	1.29326803
56	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.28574433
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28518382
58	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.26412551
59	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.17698824
60	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12227889
61	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.11687802
62	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.11528632
63	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.10619981
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10597934
65	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.10020926
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06924992
67	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06738138
68	ER_23166858_ChIP-Seq_MCF-7_Human	1.06040260
69	E2F7_22180533_ChIP-Seq_HELA_Human	1.04511361
70	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04147800
71	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.03498148
72	GATA3_26560356_Chip-Seq_TH2_Human	1.01812427
73	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.01450125
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01402198
75	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01402198
76	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.99105965
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97449773
78	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.96784219
79	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.95989249
80	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94581069
81	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.92774739
82	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.91311431
83	GATA1_22025678_ChIP-Seq_K562_Human	0.91243708
84	AR_20517297_ChIP-Seq_VCAP_Human	0.90495310
85	P300_19829295_ChIP-Seq_ESCs_Human	0.89371366
86	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.88286410
87	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.88237727
88	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.87728727
89	ELF5_23300383_ChIP-Seq_T47D_Human	0.85225007
90	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.85108202
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.84699221
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.84699221
93	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.81795119
94	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.81782187
95	KDM5A_27292631_Chip-Seq_BREAST_Human	0.80949385
96	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.80177398
97	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.80049164
98	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.76171908
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.76167056
100	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.76026804

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.48118750
2	MP0008875_abnormal_xenobiotic_pharmacok	3.36712032
3	MP0004147_increased_porphyrin_level	3.20707528
4	MP0008058_abnormal_DNA_repair	3.08536344
5	MP0006072_abnormal_retinal_apoptosis	2.86040611
6	MP0008872_abnormal_physiological_respon	2.84030064
7	MP0010094_abnormal_chromosome_stability	2.62067368
8	MP0005671_abnormal_response_to	2.61008220
9	MP0003693_abnormal_embryo_hatching	2.48716424
10	MP0003718_maternal_effect	2.47997917
11	MP0001835_abnormal_antigen_presentation	2.46345023
12	MP0004885_abnormal_endolymph	2.36674391
13	MP0002938_white_spotting	2.34011212
14	MP0006292_abnormal_olfactory_placode	2.28540530
15	MP0000372_irregular_coat_pigmentation	2.27647191
16	MP0002736_abnormal_nociception_after	2.19103898
17	MP0001348_abnormal_lacrimal_gland	2.09847835
18	MP0001873_stomach_inflammation	2.06863325
19	MP0003195_calcinosis	2.06247779
20	MP0003786_premature_aging	1.96184940
21	MP0002102_abnormal_ear_morphology	1.93371805
22	MP0005075_abnormal_melanosome_morpholog	1.84944875
23	MP0004957_abnormal_blastocyst_morpholog	1.83065021
24	MP0002148_abnormal_hypersensitivity_rea	1.76443107
25	MP0005551_abnormal_eye_electrophysiolog	1.75337618
26	MP0001968_abnormal_touch/_nociception	1.68127873
27	MP0002160_abnormal_reproductive_system	1.65217024
28	MP0001984_abnormal_olfaction	1.56575448
29	MP0005253_abnormal_eye_physiology	1.54975708
30	MP0002876_abnormal_thyroid_physiology	1.53482098
31	MP0006036_abnormal_mitochondrial_physio	1.50797418
32	MP0002006_tumorigenesis	1.46006002
33	MP0003436_decreased_susceptibility_to	1.41833679
34	MP0001293_anophthalmia	1.41229301
35	MP0001501_abnormal_sleep_pattern	1.39048409
36	MP0003763_abnormal_thymus_physiology	1.38199244
37	MP0001502_abnormal_circadian_rhythm	1.32658454
38	MP0002138_abnormal_hepatobiliary_system	1.31730458
39	MP0003878_abnormal_ear_physiology	1.28940308
40	MP0005377_hearing/vestibular/ear_phenot	1.28940308
41	MP0005084_abnormal_gallbladder_morpholo	1.26220239
42	MP0005000_abnormal_immune_tolerance	1.23824210
43	MP0003111_abnormal_nucleus_morphology	1.21448595
44	MP0003186_abnormal_redox_activity	1.20002773
45	MP0005389_reproductive_system_phenotype	1.19039586
46	MP0001800_abnormal_humoral_immune	1.18798519
47	MP0001853_heart_inflammation	1.17921741
48	MP0008789_abnormal_olfactory_epithelium	1.17474822
49	MP0000465_gastrointestinal_hemorrhage	1.17394986
50	MP0001905_abnormal_dopamine_level	1.15162571
51	MP0004145_abnormal_muscle_electrophysio	1.13060395
52	MP0001986_abnormal_taste_sensitivity	1.09991348
53	MP0003880_abnormal_central_pattern	1.09736352
54	MP0005332_abnormal_amino_acid	1.07784653
55	MP0005646_abnormal_pituitary_gland	1.05993107
56	MP0003646_muscle_fatigue	1.05643729
57	MP0001790_abnormal_immune_system	1.05039285
58	MP0005387_immune_system_phenotype	1.05039285
59	MP0003011_delayed_dark_adaptation	1.04928437
60	MP0003119_abnormal_digestive_system	1.04039399
61	MP0006035_abnormal_mitochondrial_morpho	1.02999267
62	MP0000685_abnormal_immune_system	1.01997444
63	MP0009764_decreased_sensitivity_to	1.01447292
64	MP0009785_altered_susceptibility_to	0.96415883
65	MP0009697_abnormal_copulation	0.95253155
66	MP0005410_abnormal_fertilization	0.94868847
67	MP0003866_abnormal_defecation	0.94780619
68	MP0002272_abnormal_nervous_system	0.92759338
69	MP0004782_abnormal_surfactant_physiolog	0.92531233
70	MP0001188_hyperpigmentation	0.92063530
71	MP0001485_abnormal_pinna_reflex	0.91815840
72	MP0003077_abnormal_cell_cycle	0.90545355
73	MP0002254_reproductive_system_inflammat	0.89974280
74	MP0005174_abnormal_tail_pigmentation	0.89724712
75	MP0002405_respiratory_system_inflammati	0.88648894
76	MP0001919_abnormal_reproductive_system	0.88122327
77	MP0002210_abnormal_sex_determination	0.87738015
78	MP0003567_abnormal_fetal_cardiomyocyte	0.87216926
79	MP0002234_abnormal_pharynx_morphology	0.85850142
80	MP0000653_abnormal_sex_gland	0.85579356
81	MP0002653_abnormal_ependyma_morphology	0.83418269
82	MP0002420_abnormal_adaptive_immunity	0.81882376
83	MP0001145_abnormal_male_reproductive	0.81140853
84	MP0008932_abnormal_embryonic_tissue	0.80570557
85	MP0001929_abnormal_gametogenesis	0.80483914
86	MP0002090_abnormal_vision	0.79992465
87	MP0001819_abnormal_immune_cell	0.79228362
88	MP0002723_abnormal_immune_serum	0.78966314
89	MP0001119_abnormal_female_reproductive	0.78780631
90	MP0000689_abnormal_spleen_morphology	0.76262691
91	MP0003806_abnormal_nucleotide_metabolis	0.75513803
92	MP0002019_abnormal_tumor_incidence	0.73902283
93	MP0002166_altered_tumor_susceptibility	0.73177165
94	MP0009333_abnormal_splenocyte_physiolog	0.71835500
95	MP0006054_spinal_hemorrhage	0.71835417
96	MP0002398_abnormal_bone_marrow	0.70770860
97	MP0005645_abnormal_hypothalamus_physiol	0.70228216
98	MP0002837_dystrophic_cardiac_calcinosis	0.68988859
99	MP0002452_abnormal_antigen_presenting	0.68191088
100	MP0001486_abnormal_startle_reflex	0.67832402

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.52044252
2	Dyschromatopsia (HP:0007641)	4.23319577
3	Microvesicular hepatic steatosis (HP:0001414)	3.97855090
4	Hepatocellular necrosis (HP:0001404)	3.45619532
5	Acute necrotizing encephalopathy (HP:0006965)	3.38642908
6	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.36976539
7	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.36976539
8	Mitochondrial inheritance (HP:0001427)	3.36762288
9	Visual hallucinations (HP:0002367)	3.35699881
10	Increased hepatocellular lipid droplets (HP:0006565)	3.34842308
11	Colon cancer (HP:0003003)	3.32439512
12	Increased CSF lactate (HP:0002490)	3.31025119
13	Pancreatic fibrosis (HP:0100732)	3.29247859
14	Molar tooth sign on MRI (HP:0002419)	3.23981030
15	Abnormality of midbrain morphology (HP:0002418)	3.23981030
16	Abnormal mitochondria in muscle tissue (HP:0008316)	3.20210020
17	Hepatic necrosis (HP:0002605)	3.15704530
18	Increased serum lactate (HP:0002151)	3.14630804
19	Decreased central vision (HP:0007663)	3.10739308
20	Lipid accumulation in hepatocytes (HP:0006561)	3.09033124
21	Abolished electroretinogram (ERG) (HP:0000550)	3.04636721
22	Nephronophthisis (HP:0000090)	3.00697489
23	Testicular atrophy (HP:0000029)	2.91524743
24	Methylmalonic acidemia (HP:0002912)	2.91510550
25	Pancreatic cysts (HP:0001737)	2.87263846
26	Acute encephalopathy (HP:0006846)	2.81247361
27	Progressive macrocephaly (HP:0004481)	2.76203966
28	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.64973209
29	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.59833323
30	Central scotoma (HP:0000603)	2.59565179
31	Lactic acidosis (HP:0003128)	2.57117693
32	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.56737643
33	Increased intramyocellular lipid droplets (HP:0012240)	2.52817597
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.52160113
35	Prostate neoplasm (HP:0100787)	2.48824556
36	Abnormality of the renal medulla (HP:0100957)	2.41709553
37	Abnormality of the renal cortex (HP:0011035)	2.39856544
38	IgG deficiency (HP:0004315)	2.38608996
39	Methylmalonic aciduria (HP:0012120)	2.38286508
40	Autoimmune hemolytic anemia (HP:0001890)	2.37518043
41	True hermaphroditism (HP:0010459)	2.35119571
42	Severe combined immunodeficiency (HP:0004430)	2.31124669
43	Bilateral microphthalmos (HP:0007633)	2.29750268
44	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.27208545
45	Cerebral edema (HP:0002181)	2.25283701
46	Abnormality of B cell number (HP:0010975)	2.24777477
47	Optic disc pallor (HP:0000543)	2.22113353
48	Abnormality of the labia minora (HP:0012880)	2.21852548
49	Asplenia (HP:0001746)	2.21841358
50	Renal cortical cysts (HP:0000803)	2.21763825
51	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.21544218
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.20531890
53	Abnormality of alanine metabolism (HP:0010916)	2.20531890
54	Hyperalaninemia (HP:0003348)	2.20531890
55	Aplasia/hypoplasia of the uterus (HP:0008684)	2.19430565
56	Autoimmune thrombocytopenia (HP:0001973)	2.18894931
57	Congenital stationary night blindness (HP:0007642)	2.18607674
58	Abnormality of serum amino acid levels (HP:0003112)	2.16778002
59	Type 2 muscle fiber atrophy (HP:0003554)	2.15330907
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.14362980
61	Lethargy (HP:0001254)	2.13415973
62	Congenital, generalized hypertrichosis (HP:0004540)	2.11587439
63	Bile duct proliferation (HP:0001408)	2.07643956
64	Abnormal biliary tract physiology (HP:0012439)	2.07643956
65	Exercise intolerance (HP:0003546)	2.07078445
66	Hypoplasia of the uterus (HP:0000013)	2.06514096
67	Increased muscle lipid content (HP:0009058)	2.06009080
68	Renal Fanconi syndrome (HP:0001994)	2.05593499
69	B lymphocytopenia (HP:0010976)	2.04541223
70	Abnormality of the pons (HP:0007361)	2.04530210
71	Posterior subcapsular cataract (HP:0007787)	2.04476565
72	Supernumerary spleens (HP:0009799)	2.03025717
73	Respiratory failure (HP:0002878)	2.00348542
74	Hypomagnesemia (HP:0002917)	1.99638426
75	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.99138257
76	Abnormal number of erythroid precursors (HP:0012131)	1.97079229
77	Tubular atrophy (HP:0000092)	1.96573998
78	Stomach cancer (HP:0012126)	1.96099406
79	Neoplasm of the colon (HP:0100273)	1.95165960
80	Delayed CNS myelination (HP:0002188)	1.94750988
81	Aplastic anemia (HP:0001915)	1.93471527
82	Exertional dyspnea (HP:0002875)	1.92870527
83	Scotoma (HP:0000575)	1.92243426
84	Nausea (HP:0002018)	1.91130292
85	Cerebral hypomyelination (HP:0006808)	1.91009826
86	Thyroiditis (HP:0100646)	1.90180120
87	Hypoplasia of the pons (HP:0012110)	1.89138984
88	Abnormality of the prostate (HP:0008775)	1.88675550
89	Dicarboxylic aciduria (HP:0003215)	1.87843809
90	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.87843809
91	Hypoproteinemia (HP:0003075)	1.86938367
92	Hyperglycinuria (HP:0003108)	1.83775073
93	Thyroid-stimulating hormone excess (HP:0002925)	1.82622050
94	Opisthotonus (HP:0002179)	1.81820528
95	Abnormality of vitamin B metabolism (HP:0004340)	1.81609037
96	Pendular nystagmus (HP:0012043)	1.80809803
97	Medial flaring of the eyebrow (HP:0010747)	1.80628606
98	Abnormality of macular pigmentation (HP:0008002)	1.78106487
99	Abnormal rod and cone electroretinograms (HP:0008323)	1.77764487
100	Combined immunodeficiency (HP:0005387)	1.77077958

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.50754912
2	MST4	3.44900577
3	PDK2	3.29076853
4	TAOK3	3.26674578
5	TSSK6	3.21199642
6	EIF2AK3	3.00095118
7	PBK	2.94448498
8	NEK1	2.82789583
9	BUB1	2.66572371
10	TLK1	2.53387009
11	EIF2AK1	2.52085264
12	ZAK	2.30159301
13	GRK1	2.07853419
14	ADRBK2	2.06930466
15	SRPK1	2.05354535
16	TIE1	1.99533237
17	TXK	1.96870570
18	NUAK1	1.96221678
19	KIT	1.88595786
20	NME1	1.75787433
21	MKNK1	1.65639854
22	PLK3	1.60802774
23	VRK1	1.58309978
24	PLK4	1.57205519
25	TAF1	1.44223352
26	BCKDK	1.40737760
27	BMPR1B	1.35575215
28	PINK1	1.24607034
29	WNK3	1.23597356
30	STK16	1.22238601
31	EIF2AK2	1.19897556
32	TNIK	1.18650906
33	MKNK2	1.17998407
34	TEC	1.16112121
35	TRIM28	1.15084151
36	MATK	1.08831658
37	MAPK7	1.07495643
38	IKBKB	1.06974811
39	PHKG2	1.02844734
40	PHKG1	1.02844734
41	FES	0.98622635
42	PASK	0.97208232
43	CDC7	0.94879832
44	FRK	0.87026003
45	MAP4K2	0.85603397
46	PLK1	0.82429220
47	PLK2	0.82373646
48	ALK	0.77033221
49	MAP4K1	0.73067123
50	ITK	0.72255269
51	OXSR1	0.71889129
52	STK38L	0.68589149
53	DYRK2	0.65861628
54	WNK4	0.64872083
55	IKBKE	0.63722794
56	CSNK1G1	0.63018829
57	TTK	0.62116010
58	IRAK1	0.61330377
59	INSRR	0.61299456
60	ATR	0.61221894
61	AURKB	0.59230160
62	CCNB1	0.58972195
63	STK39	0.58921109
64	NLK	0.58722721
65	RPS6KA5	0.58677742
66	DAPK1	0.58329579
67	CDK8	0.56921033
68	CSNK2A1	0.56839812
69	TGFBR1	0.56053526
70	ATM	0.53666050
71	TBK1	0.51862241
72	STK4	0.51767779
73	FER	0.50887317
74	CSNK2A2	0.49839196
75	ADRBK1	0.48979199
76	CSNK1G3	0.47331655
77	NME2	0.44250592
78	NEK6	0.44167057
79	CSNK1A1L	0.42226066
80	WEE1	0.42006389
81	MAP3K14	0.41713256
82	PTK2B	0.41417114
83	TESK2	0.40015294
84	CHEK2	0.38930609
85	LYN	0.38194548
86	FLT3	0.36995852
87	BTK	0.36279566
88	GRK5	0.36080692
89	CSNK1A1	0.35727781
90	MAPK15	0.34987440
91	OBSCN	0.33939047
92	MAP2K7	0.33711588
93	CAMK2D	0.33367222
94	PRKCQ	0.32438215
95	MAP2K2	0.32126671
96	SYK	0.32038286
97	BMPR2	0.31826867
98	PIK3CG	0.30779541
99	ACVR1B	0.29749175
100	PRKCG	0.27380040

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.32803183
2	Asthma_Homo sapiens_hsa05310	3.19205894
3	Allograft rejection_Homo sapiens_hsa05330	2.81225491
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.77848343
5	RNA polymerase_Homo sapiens_hsa03020	2.76090391
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.73519125
7	Ribosome_Homo sapiens_hsa03010	2.70289090
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.58848285
9	Mismatch repair_Homo sapiens_hsa03430	2.56684959
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.48117978
11	Protein export_Homo sapiens_hsa03060	2.34110764
12	Parkinsons disease_Homo sapiens_hsa05012	2.21899836
13	DNA replication_Homo sapiens_hsa03030	2.18561086
14	One carbon pool by folate_Homo sapiens_hsa00670	2.12924057
15	Basal transcription factors_Homo sapiens_hsa03022	2.03591467
16	Non-homologous end-joining_Homo sapiens_hsa03450	2.00642418
17	Homologous recombination_Homo sapiens_hsa03440	2.00257841
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.96666671
19	RNA degradation_Homo sapiens_hsa03018	1.94406742
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.94404541
21	Spliceosome_Homo sapiens_hsa03040	1.71852477
22	Propanoate metabolism_Homo sapiens_hsa00640	1.65185312
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.62526873
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.61075628
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.60101976
26	Graft-versus-host disease_Homo sapiens_hsa05332	1.52096024
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.51268644
28	Huntingtons disease_Homo sapiens_hsa05016	1.46711987
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.46381533
30	RNA transport_Homo sapiens_hsa03013	1.44837449
31	Purine metabolism_Homo sapiens_hsa00230	1.39974947
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.36567000
33	Base excision repair_Homo sapiens_hsa03410	1.33628067
34	Phototransduction_Homo sapiens_hsa04744	1.32925479
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.31557682
36	Caffeine metabolism_Homo sapiens_hsa00232	1.28602013
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.26261922
38	Alzheimers disease_Homo sapiens_hsa05010	1.20636954
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19640320
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.18846078
41	Primary immunodeficiency_Homo sapiens_hsa05340	1.09858058
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06912346
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00910374
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96979050
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.94357814
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.91289072
47	Antigen processing and presentation_Homo sapiens_hsa04612	0.89484649
48	Rheumatoid arthritis_Homo sapiens_hsa05323	0.86463870
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.85794927
50	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.84233712
51	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.83366387
52	Pyruvate metabolism_Homo sapiens_hsa00620	0.83124393
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79051771
54	Nitrogen metabolism_Homo sapiens_hsa00910	0.76053061
55	Sulfur metabolism_Homo sapiens_hsa00920	0.71855888
56	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.71391765
57	Steroid biosynthesis_Homo sapiens_hsa00100	0.71352198
58	Linoleic acid metabolism_Homo sapiens_hsa00591	0.68361080
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67136270
60	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.66785090
61	Fatty acid elongation_Homo sapiens_hsa00062	0.64312539
62	Peroxisome_Homo sapiens_hsa04146	0.60882175
63	Metabolic pathways_Homo sapiens_hsa01100	0.58028601
64	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.56844214
65	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52653832
66	Butanoate metabolism_Homo sapiens_hsa00650	0.52528769
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48096673
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46951078
69	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.46057106
70	Olfactory transduction_Homo sapiens_hsa04740	0.44345157
71	Fatty acid degradation_Homo sapiens_hsa00071	0.44126626
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43874326
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.41713927
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.40481851
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39579107
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39376422
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.39075069
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.38581417
79	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.36810318
80	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.34336857
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34223409
82	Glutathione metabolism_Homo sapiens_hsa00480	0.32671023
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.29776399
84	Carbon metabolism_Homo sapiens_hsa01200	0.28509639
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.28456310
86	Retinol metabolism_Homo sapiens_hsa00830	0.28282415
87	Mineral absorption_Homo sapiens_hsa04978	0.27531282
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27471263
89	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.27023255
90	p53 signaling pathway_Homo sapiens_hsa04115	0.25745921
91	Herpes simplex infection_Homo sapiens_hsa05168	0.25334903
92	Viral myocarditis_Homo sapiens_hsa05416	0.25106480
93	Regulation of autophagy_Homo sapiens_hsa04140	0.24226355
94	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.23285727
95	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.23131905
96	Cell cycle_Homo sapiens_hsa04110	0.22439323
97	Legionellosis_Homo sapiens_hsa05134	0.21503168
98	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.21176093
99	Folate biosynthesis_Homo sapiens_hsa00790	0.21043720
100	Leishmaniasis_Homo sapiens_hsa05140	0.18993942

HNRNPA1P57

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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