ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	4.71041563
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.46904937
3	ribosomal small subunit assembly (GO:0000028)	4.37255185
4	ATP synthesis coupled proton transport (GO:0015986)	4.36640708
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.36640708
6	ribosomal large subunit biogenesis (GO:0042273)	4.35784191
7	protein neddylation (GO:0045116)	4.33936426
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.24611509
9	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.13617383
10	maturation of SSU-rRNA (GO:0030490)	4.11240366
11	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.10085393
12	chaperone-mediated protein transport (GO:0072321)	4.02649861
13	viral transcription (GO:0019083)	3.88616949
14	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.87395177
15	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.81702470
16	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.81702470
17	translational termination (GO:0006415)	3.80307733
18	cotranslational protein targeting to membrane (GO:0006613)	3.78717925
19	protein targeting to ER (GO:0045047)	3.76106636
20	DNA deamination (GO:0045006)	3.72947106
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.72828855
22	NADH dehydrogenase complex assembly (GO:0010257)	3.72828855
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.72828855
24	protein complex biogenesis (GO:0070271)	3.61952250
25	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.61607836
26	rRNA modification (GO:0000154)	3.60932291
27	protein localization to endoplasmic reticulum (GO:0070972)	3.57366086
28	cullin deneddylation (GO:0010388)	3.47936513
29	translational elongation (GO:0006414)	3.39825306
30	rRNA catabolic process (GO:0016075)	3.38679164
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.37540603
32	GPI anchor biosynthetic process (GO:0006506)	3.36629126
33	sequestering of actin monomers (GO:0042989)	3.32007598
34	protein deneddylation (GO:0000338)	3.31716284
35	mitochondrial respiratory chain complex assembly (GO:0033108)	3.30421503
36	preassembly of GPI anchor in ER membrane (GO:0016254)	3.29429121
37	organelle disassembly (GO:1903008)	3.26249458
38	GPI anchor metabolic process (GO:0006505)	3.15461458
39	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.14842622
40	spliceosomal snRNP assembly (GO:0000387)	3.14287107
41	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.08780032
42	translational initiation (GO:0006413)	3.07592766
43	platelet dense granule organization (GO:0060155)	3.06343530
44	translation (GO:0006412)	3.05947610
45	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.04964709
46	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.01432660
47	aldehyde catabolic process (GO:0046185)	3.01265553
48	rRNA methylation (GO:0031167)	3.01009522
49	regulation of hypersensitivity (GO:0002883)	2.98044685
50	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.95109746
51	GMP metabolic process (GO:0046037)	2.94031309
52	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.88111440
53	respiratory electron transport chain (GO:0022904)	2.84766552
54	viral life cycle (GO:0019058)	2.83656423
55	electron transport chain (GO:0022900)	2.83354391
56	water-soluble vitamin biosynthetic process (GO:0042364)	2.81351775
57	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.79659279
58	isotype switching (GO:0045190)	2.79659279
59	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.79659279
60	regulation of cilium movement (GO:0003352)	2.78536996
61	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.77862919
62	cellular protein complex disassembly (GO:0043624)	2.75793828
63	mannosylation (GO:0097502)	2.75675663
64	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.75457640
65	deoxyribose phosphate catabolic process (GO:0046386)	2.75028097
66	intracellular protein transmembrane import (GO:0044743)	2.71425144
67	negative regulation of mast cell activation (GO:0033004)	2.70555094
68	oxidative phosphorylation (GO:0006119)	2.69705260
69	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.68126043
70	tRNA processing (GO:0008033)	2.68066303
71	regulation of mitotic spindle checkpoint (GO:1903504)	2.67204301
72	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.67204301
73	cellular component biogenesis (GO:0044085)	2.66033739
74	GTP biosynthetic process (GO:0006183)	2.65035680
75	positive regulation of actin cytoskeleton reorganization (GO:2000251)	2.60593271
76	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.60347323
77	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.60110217
78	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.60079979
79	branched-chain amino acid catabolic process (GO:0009083)	2.58911472
80	regulation of cellular amino acid metabolic process (GO:0006521)	2.57392895
81	purine nucleotide salvage (GO:0032261)	2.56351833
82	ncRNA catabolic process (GO:0034661)	2.56047747
83	respiratory chain complex IV assembly (GO:0008535)	2.55009705
84	L-fucose metabolic process (GO:0042354)	2.54833076
85	L-fucose catabolic process (GO:0042355)	2.54833076
86	fucose catabolic process (GO:0019317)	2.54833076
87	mRNA catabolic process (GO:0006402)	2.54812972
88	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.53435570
89	DNA replication-dependent nucleosome assembly (GO:0006335)	2.51272017
90	DNA replication-dependent nucleosome organization (GO:0034723)	2.51272017
91	protein peptidyl-prolyl isomerization (GO:0000413)	2.50225192
92	ATP biosynthetic process (GO:0006754)	2.49772377
93	peptidyl-histidine modification (GO:0018202)	2.49003202
94	DNA catabolic process, exonucleolytic (GO:0000738)	2.47608290
95	ribonucleoprotein complex biogenesis (GO:0022613)	2.44622986
96	purine nucleobase biosynthetic process (GO:0009113)	2.44139674
97	spliceosomal complex assembly (GO:0000245)	2.43483969
98	guanosine-containing compound biosynthetic process (GO:1901070)	2.43114819
99	cytochrome complex assembly (GO:0017004)	2.43066348
100	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.43005270

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.59797452
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.29508802
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.81511933
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.58675169
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.29986073
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.25489640
7	VDR_23849224_ChIP-Seq_CD4+_Human	3.09271907
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.96854230
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.86949043
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.79847806
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.70227601
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.65601618
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.65269297
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.48490896
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.44509356
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.40873267
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.31715423
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11357657
19	MYC_18940864_ChIP-ChIP_HL60_Human	2.11307787
20	EWS_26573619_Chip-Seq_HEK293_Human	1.99491487
21	TTF2_22483619_ChIP-Seq_HELA_Human	1.97955708
22	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.95174150
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.92213486
24	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.91935704
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.88517001
26	DCP1A_22483619_ChIP-Seq_HELA_Human	1.78466681
27	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.77953322
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.76611880
29	IGF1R_20145208_ChIP-Seq_DFB_Human	1.75697821
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.72004000
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71712078
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.71695596
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.66182809
34	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.63924116
35	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.61463859
36	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.60296828
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.59791946
38	VDR_22108803_ChIP-Seq_LS180_Human	1.54551980
39	FUS_26573619_Chip-Seq_HEK293_Human	1.54238253
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.53993155
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53488283
42	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.51721367
43	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.50738865
44	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.50315481
45	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.47684372
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.45371321
47	GABP_19822575_ChIP-Seq_HepG2_Human	1.42835876
48	GATA3_26560356_Chip-Seq_TH2_Human	1.41287900
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39696851
50	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.36720716
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36247174
52	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34763284
53	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.32742824
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.32045021
55	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.30951565
56	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.28899495
57	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.27847434
58	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.25527897
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22252171
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22252171
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.21887525
62	XRN2_22483619_ChIP-Seq_HELA_Human	1.21584378
63	AR_20517297_ChIP-Seq_VCAP_Human	1.18617366
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18296841
65	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17609723
66	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.17025306
67	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.14703018
68	P300_19829295_ChIP-Seq_ESCs_Human	1.13158814
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13017261
70	MYB_26560356_Chip-Seq_TH2_Human	1.11910148
71	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.10810356
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10031068
73	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10007864
74	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.09921025
75	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08043394
76	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.07131418
77	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.06606794
78	SPI1_23547873_ChIP-Seq_NB4_Human	1.05960912
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05648398
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.04939981
81	CBP_20019798_ChIP-Seq_JUKART_Human	1.04939981
82	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.02027002
83	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99683715
84	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99683715
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.98797828
86	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.98743366
87	GATA3_26560356_Chip-Seq_TH1_Human	0.98118216
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97636097
89	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.97284419
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97031347
91	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.95946811
92	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.95836320
93	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.94090047
94	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.92977800
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91963681
96	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.91756080
97	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.89825694
98	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.88734201
99	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.88486241
100	E2F7_22180533_ChIP-Seq_HELA_Human	0.87405499

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.74917418
2	MP0009379_abnormal_foot_pigmentation	3.45893442
3	MP0001835_abnormal_antigen_presentation	3.29526357
4	MP0002102_abnormal_ear_morphology	3.04735980
5	MP0006072_abnormal_retinal_apoptosis	3.04406732
6	MP0003011_delayed_dark_adaptation	2.94334350
7	MP0005671_abnormal_response_to	2.66552044
8	MP0008877_abnormal_DNA_methylation	2.22786573
9	MP0008789_abnormal_olfactory_epithelium	1.99862171
10	MP0003195_calcinosis	1.97644577
11	MP0005253_abnormal_eye_physiology	1.97328165
12	MP0003724_increased_susceptibility_to	1.95088135
13	MP0001873_stomach_inflammation	1.87142355
14	MP0008058_abnormal_DNA_repair	1.85939049
15	MP0002166_altered_tumor_susceptibility	1.82910534
16	MP0002234_abnormal_pharynx_morphology	1.78238716
17	MP0005084_abnormal_gallbladder_morpholo	1.73459385
18	MP0003787_abnormal_imprinting	1.72750716
19	MP0001800_abnormal_humoral_immune	1.70355060
20	MP0002148_abnormal_hypersensitivity_rea	1.70016262
21	MP0001529_abnormal_vocalization	1.68016608
22	MP0002751_abnormal_autonomic_nervous	1.67849350
23	MP0004147_increased_porphyrin_level	1.67299559
24	MP0001790_abnormal_immune_system	1.65034559
25	MP0005387_immune_system_phenotype	1.65034559
26	MP0008875_abnormal_xenobiotic_pharmacok	1.64156237
27	MP0000685_abnormal_immune_system	1.62382312
28	MP0009697_abnormal_copulation	1.54453442
29	MP0003806_abnormal_nucleotide_metabolis	1.53185951
30	MP0002009_preneoplasia	1.50492507
31	MP0009785_altered_susceptibility_to	1.50354673
32	MP0004142_abnormal_muscle_tone	1.49183520
33	MP0000049_abnormal_middle_ear	1.48967658
34	MP0003567_abnormal_fetal_cardiomyocyte	1.48675739
35	MP0001764_abnormal_homeostasis	1.47049457
36	MP0005551_abnormal_eye_electrophysiolog	1.44624291
37	MP0008995_early_reproductive_senescence	1.43597597
38	MP0005075_abnormal_melanosome_morpholog	1.42013453
39	MP0005394_taste/olfaction_phenotype	1.41887567
40	MP0005499_abnormal_olfactory_system	1.41887567
41	MP0009764_decreased_sensitivity_to	1.38941139
42	MP0003718_maternal_effect	1.38898306
43	MP0002723_abnormal_immune_serum	1.38858301
44	MP0002452_abnormal_antigen_presenting	1.35053703
45	MP0002006_tumorigenesis	1.34188877
46	MP0002277_abnormal_respiratory_mucosa	1.30423710
47	MP0008872_abnormal_physiological_respon	1.30302923
48	MP0005000_abnormal_immune_tolerance	1.27997428
49	MP0005646_abnormal_pituitary_gland	1.20042615
50	MP0001819_abnormal_immune_cell	1.17388303
51	MP0010094_abnormal_chromosome_stability	1.17040255
52	MP0001188_hyperpigmentation	1.16484447
53	MP0006035_abnormal_mitochondrial_morpho	1.15913604
54	MP0006082_CNS_inflammation	1.14021222
55	MP0003786_premature_aging	1.13842733
56	MP0002138_abnormal_hepatobiliary_system	1.12940812
57	MP0002420_abnormal_adaptive_immunity	1.12389684
58	MP0003186_abnormal_redox_activity	1.10618955
59	MP0005360_urolithiasis	1.09178689
60	MP0005085_abnormal_gallbladder_physiolo	1.07795634
61	MP0009333_abnormal_splenocyte_physiolog	1.07025240
62	MP0000383_abnormal_hair_follicle	1.05960287
63	MP0004885_abnormal_endolymph	1.03291019
64	MP0002090_abnormal_vision	1.02798084
65	MP0001348_abnormal_lacrimal_gland	0.99903481
66	MP0000465_gastrointestinal_hemorrhage	0.99136913
67	MP0000647_abnormal_sebaceous_gland	0.98527566
68	MP0005167_abnormal_blood-brain_barrier	0.98211457
69	MP0006036_abnormal_mitochondrial_physio	0.96461200
70	MP0005025_abnormal_response_to	0.93703950
71	MP0000631_abnormal_neuroendocrine_gland	0.93081740
72	MP0001293_anophthalmia	0.90427946
73	MP0004957_abnormal_blastocyst_morpholog	0.89235286
74	MP0001905_abnormal_dopamine_level	0.88320554
75	MP0002163_abnormal_gland_morphology	0.87422204
76	MP0000689_abnormal_spleen_morphology	0.85891648
77	MP0000716_abnormal_immune_system	0.85823587
78	MP0002398_abnormal_bone_marrow	0.84809349
79	MP0003693_abnormal_embryo_hatching	0.84470220
80	MP0005645_abnormal_hypothalamus_physiol	0.83943292
81	MP0005377_hearing/vestibular/ear_phenot	0.83673300
82	MP0003878_abnormal_ear_physiology	0.83673300
83	MP0005408_hypopigmentation	0.83317782
84	MP0002736_abnormal_nociception_after	0.82393820
85	MP0001845_abnormal_inflammatory_respons	0.81995724
86	MP0005451_abnormal_body_composition	0.77598675
87	MP0010386_abnormal_urinary_bladder	0.76822112
88	MP0004145_abnormal_muscle_electrophysio	0.76574330
89	MP0000372_irregular_coat_pigmentation	0.76003284
90	MP0010155_abnormal_intestine_physiology	0.75761111
91	MP0002419_abnormal_innate_immunity	0.74638278
92	MP0003436_decreased_susceptibility_to	0.74312678
93	MP0003119_abnormal_digestive_system	0.74040377
94	MP0002405_respiratory_system_inflammati	0.72951744
95	MP0002938_white_spotting	0.71428206
96	MP0002722_abnormal_immune_system	0.71286981
97	MP0005389_reproductive_system_phenotype	0.70891017
98	MP0008007_abnormal_cellular_replicative	0.70564728
99	MP0003252_abnormal_bile_duct	0.70185585
100	MP0003221_abnormal_cardiomyocyte_apopto	0.70071999

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.86418867
2	Methylmalonic acidemia (HP:0002912)	3.78370236
3	Lipid accumulation in hepatocytes (HP:0006561)	3.53932564
4	Mitochondrial inheritance (HP:0001427)	3.53139402
5	Increased hepatocellular lipid droplets (HP:0006565)	3.50062279
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.38150497
7	Acute encephalopathy (HP:0006846)	3.36606774
8	Increased CSF lactate (HP:0002490)	3.34668471
9	Progressive macrocephaly (HP:0004481)	3.14744179
10	Hepatocellular necrosis (HP:0001404)	3.13923613
11	Nephronophthisis (HP:0000090)	3.13520246
12	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.06267845
13	Abnormality of midbrain morphology (HP:0002418)	3.03789796
14	Molar tooth sign on MRI (HP:0002419)	3.03789796
15	3-Methylglutaconic aciduria (HP:0003535)	2.95404455
16	Hepatic necrosis (HP:0002605)	2.89096858
17	Methylmalonic aciduria (HP:0012120)	2.86786454
18	Type I transferrin isoform profile (HP:0003642)	2.85630914
19	Reduced antithrombin III activity (HP:0001976)	2.84947640
20	Thyroid-stimulating hormone excess (HP:0002925)	2.77204039
21	Cerebral edema (HP:0002181)	2.72987618
22	Hyperglycinemia (HP:0002154)	2.68842015
23	Colon cancer (HP:0003003)	2.65651457
24	Congenital, generalized hypertrichosis (HP:0004540)	2.63870561
25	Pancreatic cysts (HP:0001737)	2.63585127
26	Hypoproteinemia (HP:0003075)	2.61915724
27	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.58880067
28	Exertional dyspnea (HP:0002875)	2.57830511
29	Stomatitis (HP:0010280)	2.55304757
30	IgG deficiency (HP:0004315)	2.53512924
31	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.46930293
32	Abnormal protein N-linked glycosylation (HP:0012347)	2.46930293
33	Abnormal protein glycosylation (HP:0012346)	2.46930293
34	Abnormal glycosylation (HP:0012345)	2.46930293
35	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.44739874
36	Abnormality of alanine metabolism (HP:0010916)	2.44739874
37	Hyperalaninemia (HP:0003348)	2.44739874
38	Renal Fanconi syndrome (HP:0001994)	2.42386447
39	Reticulocytopenia (HP:0001896)	2.42269294
40	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.40174444
41	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.35411216
42	Increased serum lactate (HP:0002151)	2.34291505
43	Increased intramyocellular lipid droplets (HP:0012240)	2.33874286
44	Abnormality of the prostate (HP:0008775)	2.32322409
45	Abnormality of the renal medulla (HP:0100957)	2.26825399
46	Renal cortical cysts (HP:0000803)	2.25806628
47	True hermaphroditism (HP:0010459)	2.24529860
48	Lactic acidosis (HP:0003128)	2.23860092
49	Optic disc pallor (HP:0000543)	2.23544163
50	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.22624545
51	Stenosis of the external auditory canal (HP:0000402)	2.20262252
52	Abnormality of methionine metabolism (HP:0010901)	2.17636011
53	Macrocytic anemia (HP:0001972)	2.14753917
54	Exercise intolerance (HP:0003546)	2.14711328
55	Type 2 muscle fiber atrophy (HP:0003554)	2.13094173
56	Abnormality of the pons (HP:0007361)	2.11534359
57	Poor head control (HP:0002421)	2.09562313
58	Respiratory difficulties (HP:0002880)	2.09376834
59	Neonatal respiratory distress (HP:0002643)	2.09162186
60	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.07904465
61	Abolished electroretinogram (ERG) (HP:0000550)	2.06951043
62	Abnormality of serum amino acid levels (HP:0003112)	2.06872918
63	Medial flaring of the eyebrow (HP:0010747)	2.06532509
64	Pancreatic fibrosis (HP:0100732)	2.06484691
65	Lethargy (HP:0001254)	2.05740018
66	CNS demyelination (HP:0007305)	2.03816856
67	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.02392394
68	Increased muscle lipid content (HP:0009058)	2.02055740
69	Inability to walk (HP:0002540)	1.97515131
70	Pallor (HP:0000980)	1.95911829
71	Progressive inability to walk (HP:0002505)	1.94278537
72	Leukodystrophy (HP:0002415)	1.93688801
73	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.92587824
74	Abnormality of T cell physiology (HP:0011840)	1.91607676
75	Brushfield spots (HP:0001088)	1.90945050
76	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.90485821
77	Dicarboxylic aciduria (HP:0003215)	1.90485821
78	Congenital stationary night blindness (HP:0007642)	1.90050099
79	Abnormality of DNA repair (HP:0003254)	1.89939967
80	Type II lissencephaly (HP:0007260)	1.87996252
81	Attenuation of retinal blood vessels (HP:0007843)	1.85937761
82	Constricted visual fields (HP:0001133)	1.85636928
83	Pancytopenia (HP:0001876)	1.85367161
84	Delayed CNS myelination (HP:0002188)	1.84401391
85	Increased IgM level (HP:0003496)	1.84314277
86	Medulloblastoma (HP:0002885)	1.82400978
87	Neoplasm of the tracheobronchial system (HP:0100552)	1.81119760
88	Aplasia/hypoplasia of the uterus (HP:0008684)	1.79692012
89	Hypoplasia of the pons (HP:0012110)	1.79686539
90	Abnormality of the renal cortex (HP:0011035)	1.78358302
91	Abnormality of vitamin B metabolism (HP:0004340)	1.78274281
92	Muscle fiber atrophy (HP:0100295)	1.77868880
93	Bile duct proliferation (HP:0001408)	1.77591983
94	Abnormal biliary tract physiology (HP:0012439)	1.77591983
95	Adactyly (HP:0009776)	1.77408922
96	Elevated erythrocyte sedimentation rate (HP:0003565)	1.76240631
97	Abnormality of serine family amino acid metabolism (HP:0010894)	1.74843779
98	Abnormality of glycine metabolism (HP:0010895)	1.74843779
99	Increased serum pyruvate (HP:0003542)	1.74012979
100	Respiratory failure (HP:0002878)	1.73550956

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.53091718
2	VRK2	3.31677983
3	ZAK	3.12234259
4	BCKDK	2.95266010
5	INSRR	2.89884546
6	SRPK1	2.67771748
7	TLK1	2.61530944
8	EIF2AK3	2.56908362
9	MUSK	2.43948225
10	MKNK1	2.33309400
11	TXK	2.29334817
12	MAP3K4	2.26455547
13	GRK1	2.12818086
14	BCR	2.05074870
15	TRIM28	2.03451701
16	ADRBK2	1.83764714
17	NUAK1	1.81999968
18	VRK1	1.71420556
19	ERBB3	1.56617650
20	BMPR2	1.41599421
21	TAOK3	1.40406930
22	BMPR1B	1.36702086
23	NME1	1.36692436
24	EIF2AK2	1.34535858
25	CSNK1G3	1.28332339
26	CDK19	1.25465843
27	CSNK1A1L	1.22625414
28	TEC	1.22102628
29	STK16	1.22062760
30	WNK3	1.21256991
31	IKBKE	1.21016636
32	IKBKB	1.18783969
33	FES	1.18317677
34	PINK1	1.17278716
35	TAF1	1.17040320
36	FRK	1.07050318
37	TIE1	1.06923855
38	TSSK6	1.05607956
39	CSNK1G2	1.02287349
40	CSNK1G1	0.99733379
41	PASK	0.99455141
42	MAP3K14	0.97959559
43	NME2	0.97005489
44	CDC7	0.92536849
45	MAPKAPK5	0.91749184
46	DYRK2	0.88378808
47	MATK	0.86048727
48	MST4	0.85751099
49	STK38L	0.83088606
50	PLK3	0.81966723
51	KIT	0.79510002
52	TRPM7	0.79019035
53	BUB1	0.78682422
54	PBK	0.74078387
55	MAP2K7	0.71981464
56	ITK	0.71930770
57	SCYL2	0.71862928
58	TNIK	0.70234885
59	CDK8	0.69938120
60	RPS6KA4	0.64725087
61	LYN	0.63637860
62	DAPK1	0.63016856
63	ATR	0.62639611
64	NEK1	0.60835387
65	CHUK	0.60491384
66	NEK2	0.59742382
67	RPS6KA5	0.59135225
68	PLK4	0.57650711
69	CSF1R	0.56417503
70	HCK	0.55973026
71	CDK6	0.55484310
72	STK24	0.54242457
73	GRK6	0.53224991
74	JAK3	0.53217347
75	MAPK13	0.53165736
76	SYK	0.52923317
77	WNK4	0.52329898
78	TGFBR1	0.50505152
79	BTK	0.50214789
80	NEK9	0.49798680
81	DAPK2	0.47766224
82	IRAK4	0.47548552
83	AURKB	0.47315104
84	FLT3	0.46553130
85	CAMKK2	0.46348723
86	CSNK2A1	0.46157418
87	PRKCQ	0.42503026
88	SIK3	0.42201050
89	CSNK2A2	0.40125316
90	MAP4K1	0.39305891
91	EPHA3	0.38827555
92	LCK	0.38303724
93	IRAK1	0.37933559
94	CDK4	0.37738382
95	MAP2K6	0.36030031
96	MAPKAPK3	0.34142880
97	PRKCE	0.32373537
98	MAP3K12	0.32017519
99	OXSR1	0.31449989
100	CSNK1A1	0.31168290

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	4.02958430
2	Ribosome_Homo sapiens_hsa03010	3.65854810
3	Proteasome_Homo sapiens_hsa03050	3.52752670
4	Asthma_Homo sapiens_hsa05310	3.35344891
5	Oxidative phosphorylation_Homo sapiens_hsa00190	3.18671947
6	Parkinsons disease_Homo sapiens_hsa05012	2.60318814
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.41106673
8	RNA polymerase_Homo sapiens_hsa03020	2.38700583
9	Allograft rejection_Homo sapiens_hsa05330	2.27471680
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.17526328
11	RNA degradation_Homo sapiens_hsa03018	2.16991345
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.07243859
13	Propanoate metabolism_Homo sapiens_hsa00640	2.02481176
14	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.93758060
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.92306077
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.90905116
17	Spliceosome_Homo sapiens_hsa03040	1.85347369
18	Base excision repair_Homo sapiens_hsa03410	1.74694241
19	Homologous recombination_Homo sapiens_hsa03440	1.72645219
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.71763136
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.70737537
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.69483848
23	Huntingtons disease_Homo sapiens_hsa05016	1.64855671
24	Basal transcription factors_Homo sapiens_hsa03022	1.64642834
25	RNA transport_Homo sapiens_hsa03013	1.63071900
26	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.52807549
27	DNA replication_Homo sapiens_hsa03030	1.46624686
28	Phototransduction_Homo sapiens_hsa04744	1.45553835
29	Alzheimers disease_Homo sapiens_hsa05010	1.44972136
30	Mismatch repair_Homo sapiens_hsa03430	1.34353813
31	Purine metabolism_Homo sapiens_hsa00230	1.29508175
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.29109291
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24566829
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.24173253
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.23904907
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.22372785
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.21816025
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.20088341
39	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.16521081
40	One carbon pool by folate_Homo sapiens_hsa00670	1.13881056
41	Antigen processing and presentation_Homo sapiens_hsa04612	1.10565667
42	Fanconi anemia pathway_Homo sapiens_hsa03460	1.04562599
43	Peroxisome_Homo sapiens_hsa04146	1.02902424
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.93933523
45	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.93062350
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.92162442
47	Rheumatoid arthritis_Homo sapiens_hsa05323	0.90887218
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.89689783
49	Steroid biosynthesis_Homo sapiens_hsa00100	0.83739017
50	Cardiac muscle contraction_Homo sapiens_hsa04260	0.83095497
51	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.79307195
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.77905675
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.77798955
54	Glutathione metabolism_Homo sapiens_hsa00480	0.77059659
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.73744901
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.68766772
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.68302305
58	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.68012380
59	Sulfur metabolism_Homo sapiens_hsa00920	0.67733642
60	Butanoate metabolism_Homo sapiens_hsa00650	0.65110744
61	Herpes simplex infection_Homo sapiens_hsa05168	0.63461594
62	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.63005423
63	Metabolic pathways_Homo sapiens_hsa01100	0.59761938
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.58857313
65	Regulation of autophagy_Homo sapiens_hsa04140	0.58682095
66	Linoleic acid metabolism_Homo sapiens_hsa00591	0.58133352
67	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57699942
68	Retinol metabolism_Homo sapiens_hsa00830	0.56661767
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55582101
70	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.54956442
71	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.54677628
72	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.54565308
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.53183728
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53182523
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.52722342
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50357222
77	Tryptophan metabolism_Homo sapiens_hsa00380	0.50343775
78	Leishmaniasis_Homo sapiens_hsa05140	0.49760888
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49673914
80	Viral myocarditis_Homo sapiens_hsa05416	0.49475057
81	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.48802795
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48589607
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48006914
84	Taste transduction_Homo sapiens_hsa04742	0.46453166
85	Pyruvate metabolism_Homo sapiens_hsa00620	0.46416442
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40898161
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40478526
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39457648
89	Olfactory transduction_Homo sapiens_hsa04740	0.36438242
90	Ether lipid metabolism_Homo sapiens_hsa00565	0.36212588
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.36041712
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.32704779
93	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.32159336
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.31902216
95	Legionellosis_Homo sapiens_hsa05134	0.31551954
96	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.30754942
97	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.29299604
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.28021321
99	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.26911786
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.25036898

HNRNPA1P59

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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