ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.43699723
2	protein neddylation (GO:0045116)	4.57960588
3	ribosomal small subunit assembly (GO:0000028)	4.42893691
4	ATP synthesis coupled proton transport (GO:0015986)	4.39377798
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.39377798
6	response to pheromone (GO:0019236)	4.06481537
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.98589328
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.94083358
9	proteasome assembly (GO:0043248)	3.92952274
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.92736878
11	rRNA modification (GO:0000154)	3.86194844
12	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.80189328
13	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.68056328
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.61303695
15	pseudouridine synthesis (GO:0001522)	3.59817470
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.54037471
17	DNA double-strand break processing (GO:0000729)	3.53580012
18	termination of RNA polymerase III transcription (GO:0006386)	3.52591236
19	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.52591236
20	protein-cofactor linkage (GO:0018065)	3.52575827
21	chaperone-mediated protein transport (GO:0072321)	3.49243988
22	rRNA methylation (GO:0031167)	3.45532636
23	maturation of SSU-rRNA (GO:0030490)	3.35835075
24	protein complex biogenesis (GO:0070271)	3.35763415
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.30322182
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.30322182
27	NADH dehydrogenase complex assembly (GO:0010257)	3.30322182
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.19472632
29	behavioral response to nicotine (GO:0035095)	3.17643859
30	DNA catabolic process, exonucleolytic (GO:0000738)	3.13553885
31	electron transport chain (GO:0022900)	3.12115178
32	respiratory electron transport chain (GO:0022904)	3.10484626
33	piRNA metabolic process (GO:0034587)	3.09051169
34	resolution of meiotic recombination intermediates (GO:0000712)	3.06842108
35	base-excision repair, AP site formation (GO:0006285)	2.99859542
36	isotype switching (GO:0045190)	2.99522941
37	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.99522941
38	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.99522941
39	DNA replication-dependent nucleosome assembly (GO:0006335)	2.96275213
40	DNA replication-dependent nucleosome organization (GO:0034723)	2.96275213
41	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.93524046
42	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.90632719
43	platelet dense granule organization (GO:0060155)	2.89904806
44	cullin deneddylation (GO:0010388)	2.89124391
45	protein deneddylation (GO:0000338)	2.88704094
46	negative regulation of mast cell activation (GO:0033004)	2.87923787
47	tRNA processing (GO:0008033)	2.87702786
48	L-fucose catabolic process (GO:0042355)	2.87103876
49	fucose catabolic process (GO:0019317)	2.87103876
50	L-fucose metabolic process (GO:0042354)	2.87103876
51	cytidine catabolic process (GO:0006216)	2.87077778
52	cytidine deamination (GO:0009972)	2.87077778
53	cytidine metabolic process (GO:0046087)	2.87077778
54	replication fork processing (GO:0031297)	2.86731535
55	maturation of 5.8S rRNA (GO:0000460)	2.83558640
56	respiratory chain complex IV assembly (GO:0008535)	2.79783874
57	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.77921980
58	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.75790849
59	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.75790849
60	ribosomal large subunit biogenesis (GO:0042273)	2.75373782
61	regulation of cellular amino acid metabolic process (GO:0006521)	2.74543006
62	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.74476191
63	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.72832493
64	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.72832493
65	chromatin remodeling at centromere (GO:0031055)	2.71796797
66	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.71047832
67	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.71047832
68	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.71047832
69	mannosylation (GO:0097502)	2.70884785
70	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.70377941
71	negative regulation of telomere maintenance (GO:0032205)	2.70334545
72	iron-sulfur cluster assembly (GO:0016226)	2.70333894
73	metallo-sulfur cluster assembly (GO:0031163)	2.70333894
74	rRNA processing (GO:0006364)	2.69594685
75	peptidyl-histidine modification (GO:0018202)	2.68328097
76	spliceosomal snRNP assembly (GO:0000387)	2.68070858
77	kynurenine metabolic process (GO:0070189)	2.67754554
78	regulation of mitotic spindle checkpoint (GO:1903504)	2.67414772
79	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.67414772
80	indolalkylamine metabolic process (GO:0006586)	2.66915697
81	recombinational repair (GO:0000725)	2.66295357
82	rRNA metabolic process (GO:0016072)	2.66283029
83	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.66272744
84	double-strand break repair via homologous recombination (GO:0000724)	2.64496556
85	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.64384535
86	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.64384535
87	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.64376846
88	translation (GO:0006412)	2.61016422
89	synapsis (GO:0007129)	2.60697260
90	negative regulation of ligase activity (GO:0051352)	2.57835062
91	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.57835062
92	CENP-A containing nucleosome assembly (GO:0034080)	2.57792316
93	cytochrome complex assembly (GO:0017004)	2.57781475
94	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.56822599
95	GTP biosynthetic process (GO:0006183)	2.55797961
96	sequestering of actin monomers (GO:0042989)	2.54914514
97	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.54864023
98	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.54864023
99	protein targeting to mitochondrion (GO:0006626)	2.51881195
100	DNA demethylation (GO:0080111)	2.50648861

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.18276226
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.09679274
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.44689775
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.12241484
5	VDR_22108803_ChIP-Seq_LS180_Human	3.12056701
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.07479937
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.71335893
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.63203166
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.62164344
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.54881994
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.53119346
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.48174463
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.47187633
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.27377304
15	EWS_26573619_Chip-Seq_HEK293_Human	2.26577708
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.25266766
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.22414527
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.18189181
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.13976479
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.02262338
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.01807723
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.94603706
23	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.89706697
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.85008679
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83435303
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.83263447
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.81490573
28	FUS_26573619_Chip-Seq_HEK293_Human	1.76417962
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.75807490
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74115315
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.70820432
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.62692219
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.60674172
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59482110
35	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.58525169
36	TAF15_26573619_Chip-Seq_HEK293_Human	1.54605263
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.50521055
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.45076434
39	P300_19829295_ChIP-Seq_ESCs_Human	1.45035304
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.44487404
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.43733450
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43269552
43	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.42887885
44	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.40446658
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.38534280
46	EZH2_22144423_ChIP-Seq_EOC_Human	1.35862022
47	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.34767113
48	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.33397381
49	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.32641425
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32318663
51	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.31482127
52	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.29666566
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.27748197
54	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.26707601
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24154498
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24154498
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.23985923
58	GABP_19822575_ChIP-Seq_HepG2_Human	1.22314233
59	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22122814
60	DCP1A_22483619_ChIP-Seq_HELA_Human	1.22054203
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21775612
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21775612
63	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.21469589
64	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.21140334
65	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.18928086
66	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.18318869
67	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18144302
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.12858029
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12858029
70	AR_20517297_ChIP-Seq_VCAP_Human	1.11513139
71	NCOR_22424771_ChIP-Seq_293T_Human	1.09642928
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06328540
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04981118
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03925527
75	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.03703767
76	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.02330213
77	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01836231
78	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.00254372
79	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98288173
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96835019
81	GATA3_26560356_Chip-Seq_TH2_Human	0.95413686
82	HTT_18923047_ChIP-ChIP_STHdh_Human	0.94085681
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94035440
84	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.93714409
85	GBX2_23144817_ChIP-Seq_PC3_Human	0.93603326
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93414580
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93390756
88	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.92661156
89	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92232979
90	BCAT_22108803_ChIP-Seq_LS180_Human	0.91665459
91	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91028625
92	TCF4_22108803_ChIP-Seq_LS180_Human	0.90480391
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.90331566
94	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.88349062
95	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.88219986
96	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.87520245
97	XRN2_22483619_ChIP-Seq_HELA_Human	0.87481646
98	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.85759628
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.85490828
100	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.85317426

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.28355682
2	MP0002102_abnormal_ear_morphology	3.07384408
3	MP0008058_abnormal_DNA_repair	2.99210815
4	MP0006292_abnormal_olfactory_placode	2.98997821
5	MP0002837_dystrophic_cardiac_calcinosis	2.31112777
6	MP0005671_abnormal_response_to	2.30038385
7	MP0009379_abnormal_foot_pigmentation	2.24898071
8	MP0004885_abnormal_endolymph	2.22040138
9	MP0000372_irregular_coat_pigmentation	2.20177147
10	MP0008872_abnormal_physiological_respon	2.17939604
11	MP0006072_abnormal_retinal_apoptosis	2.17439435
12	MP0004147_increased_porphyrin_level	2.13289920
13	MP0008875_abnormal_xenobiotic_pharmacok	1.98665268
14	MP0005551_abnormal_eye_electrophysiolog	1.92917869
15	MP0005646_abnormal_pituitary_gland	1.88026191
16	MP0005084_abnormal_gallbladder_morpholo	1.80015332
17	MP0001968_abnormal_touch/_nociception	1.79827410
18	MP0001188_hyperpigmentation	1.79757628
19	MP0001485_abnormal_pinna_reflex	1.78158416
20	MP0005645_abnormal_hypothalamus_physiol	1.77610976
21	MP0002938_white_spotting	1.70589452
22	MP0003195_calcinosis	1.65976384
23	MP0010094_abnormal_chromosome_stability	1.64567816
24	MP0003718_maternal_effect	1.63953525
25	MP0001873_stomach_inflammation	1.63307644
26	MP0002736_abnormal_nociception_after	1.61386980
27	MP0003786_premature_aging	1.60206372
28	MP0003567_abnormal_fetal_cardiomyocyte	1.56664417
29	MP0005075_abnormal_melanosome_morpholog	1.55508711
30	MP0003136_yellow_coat_color	1.54342394
31	MP0001529_abnormal_vocalization	1.48686862
32	MP0004142_abnormal_muscle_tone	1.48141889
33	MP0002638_abnormal_pupillary_reflex	1.47368501
34	MP0003693_abnormal_embryo_hatching	1.43300227
35	MP0005377_hearing/vestibular/ear_phenot	1.42871226
36	MP0003878_abnormal_ear_physiology	1.42871226
37	MP0006036_abnormal_mitochondrial_physio	1.42570146
38	MP0001293_anophthalmia	1.41086489
39	MP0003787_abnormal_imprinting	1.37603065
40	MP0002735_abnormal_chemical_nociception	1.37281650
41	MP0006276_abnormal_autonomic_nervous	1.36828208
42	MP0001835_abnormal_antigen_presentation	1.34674442
43	MP0005253_abnormal_eye_physiology	1.31460330
44	MP0008057_abnormal_DNA_replication	1.26468410
45	MP0004145_abnormal_muscle_electrophysio	1.26035802
46	MP0008995_early_reproductive_senescence	1.25403419
47	MP0008789_abnormal_olfactory_epithelium	1.24931726
48	MP0000631_abnormal_neuroendocrine_gland	1.22258533
49	MP0004133_heterotaxia	1.22135731
50	MP0002876_abnormal_thyroid_physiology	1.20195837
51	MP0005389_reproductive_system_phenotype	1.18281107
52	MP0003880_abnormal_central_pattern	1.17039150
53	MP0002272_abnormal_nervous_system	1.14869021
54	MP0001919_abnormal_reproductive_system	1.11814342
55	MP0003646_muscle_fatigue	1.10809096
56	MP0005410_abnormal_fertilization	1.10769346
57	MP0002138_abnormal_hepatobiliary_system	1.10570904
58	MP0001764_abnormal_homeostasis	1.10078229
59	MP0000569_abnormal_digit_pigmentation	1.09620925
60	MP0002095_abnormal_skin_pigmentation	1.07109487
61	MP0004957_abnormal_blastocyst_morpholog	1.06909613
62	MP0002277_abnormal_respiratory_mucosa	1.04969842
63	MP0003011_delayed_dark_adaptation	1.04610459
64	MP0003890_abnormal_embryonic-extraembry	1.04438114
65	MP0005174_abnormal_tail_pigmentation	1.04403098
66	MP0001929_abnormal_gametogenesis	1.02536340
67	MP0002733_abnormal_thermal_nociception	1.02415852
68	MP0004742_abnormal_vestibular_system	1.02138877
69	MP0003806_abnormal_nucleotide_metabolis	1.01170131
70	MP0001984_abnormal_olfaction	1.00901134
71	MP0003121_genomic_imprinting	1.00664375
72	MP0006035_abnormal_mitochondrial_morpho	1.00362269
73	MP0001905_abnormal_dopamine_level	1.00027478
74	MP0002210_abnormal_sex_determination	0.99696801
75	MP0002234_abnormal_pharynx_morphology	0.97150546
76	MP0001986_abnormal_taste_sensitivity	0.96700476
77	MP0003186_abnormal_redox_activity	0.96050873
78	MP0000049_abnormal_middle_ear	0.95211025
79	MP0002160_abnormal_reproductive_system	0.94739367
80	MP0009745_abnormal_behavioral_response	0.92912330
81	MP0003122_maternal_imprinting	0.89076371
82	MP0009785_altered_susceptibility_to	0.87950455
83	MP0001486_abnormal_startle_reflex	0.87785030
84	MP0002148_abnormal_hypersensitivity_rea	0.84991111
85	MP0000653_abnormal_sex_gland	0.84467687
86	MP0002751_abnormal_autonomic_nervous	0.84243035
87	MP0003698_abnormal_male_reproductive	0.84112249
88	MP0001970_abnormal_pain_threshold	0.81837929
89	MP0001800_abnormal_humoral_immune	0.81264611
90	MP0009333_abnormal_splenocyte_physiolog	0.76902739
91	MP0004215_abnormal_myocardial_fiber	0.75990555
92	MP0001145_abnormal_male_reproductive	0.75364695
93	MP0005636_abnormal_mineral_homeostasis	0.74310333
94	MP0009046_muscle_twitch	0.69168626
95	MP0003111_abnormal_nucleus_morphology	0.69009530
96	MP0005387_immune_system_phenotype	0.68749670
97	MP0001790_abnormal_immune_system	0.68749670
98	MP0005499_abnormal_olfactory_system	0.68015075
99	MP0005394_taste/olfaction_phenotype	0.68015075
100	MP0001119_abnormal_female_reproductive	0.67929975

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.82981571
2	Mitochondrial inheritance (HP:0001427)	3.57025584
3	Pancreatic cysts (HP:0001737)	3.56981941
4	Acute encephalopathy (HP:0006846)	3.46087328
5	Increased hepatocellular lipid droplets (HP:0006565)	3.42700488
6	Increased CSF lactate (HP:0002490)	3.39512763
7	True hermaphroditism (HP:0010459)	3.31791525
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.31168075
9	Lipid accumulation in hepatocytes (HP:0006561)	3.25767029
10	Colon cancer (HP:0003003)	3.18370046
11	3-Methylglutaconic aciduria (HP:0003535)	3.15984365
12	Pancreatic fibrosis (HP:0100732)	3.12125395
13	Progressive macrocephaly (HP:0004481)	3.11284812
14	Methylmalonic acidemia (HP:0002912)	3.03114978
15	Congenital stationary night blindness (HP:0007642)	3.01686259
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.98137270
17	Renal Fanconi syndrome (HP:0001994)	2.96439900
18	Hepatocellular necrosis (HP:0001404)	2.94657782
19	Nephronophthisis (HP:0000090)	2.92979218
20	Abnormality of midbrain morphology (HP:0002418)	2.91675734
21	Molar tooth sign on MRI (HP:0002419)	2.91675734
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.73297900
23	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.71663170
24	Abnormality of alanine metabolism (HP:0010916)	2.71663170
25	Hyperalaninemia (HP:0003348)	2.71663170
26	Hepatic necrosis (HP:0002605)	2.70153204
27	Increased serum lactate (HP:0002151)	2.66359602
28	Cerebral edema (HP:0002181)	2.57121681
29	Hypoproteinemia (HP:0003075)	2.52422018
30	Attenuation of retinal blood vessels (HP:0007843)	2.51823317
31	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.50930747
32	IgG deficiency (HP:0004315)	2.50215517
33	Hyperglycinemia (HP:0002154)	2.49095936
34	Stomatitis (HP:0010280)	2.48273092
35	Optic disc pallor (HP:0000543)	2.45653353
36	Decreased central vision (HP:0007663)	2.40917955
37	Pendular nystagmus (HP:0012043)	2.39513379
38	Abnormality of the labia minora (HP:0012880)	2.38364497
39	Abnormality of the renal medulla (HP:0100957)	2.37452028
40	Abolished electroretinogram (ERG) (HP:0000550)	2.36043622
41	Methylmalonic aciduria (HP:0012120)	2.33285214
42	Abnormality of the renal cortex (HP:0011035)	2.33043161
43	Sclerocornea (HP:0000647)	2.31600135
44	Abnormality of B cell number (HP:0010975)	2.27110769
45	Abnormality of serum amino acid levels (HP:0003112)	2.26910752
46	Medial flaring of the eyebrow (HP:0010747)	2.25818974
47	Lactic acidosis (HP:0003128)	2.25758607
48	Exertional dyspnea (HP:0002875)	2.24569867
49	Renal cortical cysts (HP:0000803)	2.15052832
50	Abnormal number of erythroid precursors (HP:0012131)	2.13154020
51	Type II lissencephaly (HP:0007260)	2.11854459
52	Constricted visual fields (HP:0001133)	2.11451862
53	Increased intramyocellular lipid droplets (HP:0012240)	2.10953049
54	Abnormality of cells of the erythroid lineage (HP:0012130)	2.06199316
55	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.04668133
56	Abnormality of the ileum (HP:0001549)	2.03159583
57	Meckel diverticulum (HP:0002245)	1.98723690
58	Lethargy (HP:0001254)	1.98169463
59	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.98152999
60	Cystic liver disease (HP:0006706)	1.95341714
61	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.94608458
62	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.94608458
63	Absent thumb (HP:0009777)	1.94575583
64	Reticulocytopenia (HP:0001896)	1.93714951
65	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.93253336
66	Abnormality of renal resorption (HP:0011038)	1.92340744
67	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.92167346
68	Type I transferrin isoform profile (HP:0003642)	1.91793499
69	Septo-optic dysplasia (HP:0100842)	1.90034047
70	Increased IgM level (HP:0003496)	1.87932901
71	Postaxial foot polydactyly (HP:0001830)	1.86951353
72	Hyperglycinuria (HP:0003108)	1.86520636
73	Glycosuria (HP:0003076)	1.86460135
74	Abnormality of urine glucose concentration (HP:0011016)	1.86460135
75	Aplasia/hypoplasia of the uterus (HP:0008684)	1.85780127
76	Abnormality of serine family amino acid metabolism (HP:0010894)	1.85056677
77	Abnormality of glycine metabolism (HP:0010895)	1.85056677
78	Congenital hepatic fibrosis (HP:0002612)	1.84895451
79	Male pseudohermaphroditism (HP:0000037)	1.84720876
80	Keratoconus (HP:0000563)	1.83290988
81	Increased corneal curvature (HP:0100692)	1.83290988
82	Congenital, generalized hypertrichosis (HP:0004540)	1.82951796
83	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.82543971
84	Respiratory difficulties (HP:0002880)	1.81718762
85	Respiratory failure (HP:0002878)	1.80836038
86	Aplastic anemia (HP:0001915)	1.80573677
87	Polydipsia (HP:0001959)	1.79538167
88	Abnormal drinking behavior (HP:0030082)	1.79538167
89	Abnormality of chromosome stability (HP:0003220)	1.79527348
90	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.78506857
91	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.76990921
92	Asplenia (HP:0001746)	1.76856276
93	Abnormality of the pons (HP:0007361)	1.76294851
94	Type 2 muscle fiber atrophy (HP:0003554)	1.76165464
95	B lymphocytopenia (HP:0010976)	1.74882641
96	Optic nerve hypoplasia (HP:0000609)	1.74042394
97	Abnormality of vitamin B metabolism (HP:0004340)	1.73754252
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.73251519
99	Increased muscle lipid content (HP:0009058)	1.72516023
100	Leukodystrophy (HP:0002415)	1.70804334

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.35076252
2	TXK	3.33972130
3	VRK2	2.91775896
4	MAP4K2	2.77231591
5	TRIM28	2.73119836
6	NUAK1	2.61959338
7	ADRBK2	2.22809676
8	BCKDK	2.21743783
9	GRK1	2.17261408
10	TLK1	2.14305049
11	VRK1	2.11881518
12	WNK3	2.06885672
13	FRK	2.02856710
14	MKNK1	2.00443929
15	TSSK6	1.99634415
16	WNK4	1.98521755
17	BUB1	1.93013824
18	PINK1	1.79494203
19	EIF2AK3	1.69133714
20	MST4	1.68180542
21	PLK4	1.65590920
22	PASK	1.53946175
23	SRPK1	1.52861240
24	PLK3	1.43833499
25	MKNK2	1.42159703
26	NME1	1.41135035
27	TAOK3	1.33298552
28	TIE1	1.31179427
29	PBK	1.29469648
30	STK39	1.29457225
31	TEC	1.29445184
32	NEK1	1.27517049
33	TAF1	1.21644908
34	DYRK2	1.18797181
35	OXSR1	1.18371995
36	CDK19	1.14906438
37	CDC7	1.14408676
38	BMPR1B	1.14152746
39	TNIK	1.08666930
40	MAP3K4	1.02890047
41	MAPK13	1.01005989
42	EIF2AK1	0.96365734
43	MAP4K1	0.95422248
44	STK16	0.92273662
45	MAP2K7	0.90457646
46	CSNK1G3	0.90143826
47	KDR	0.90050586
48	ITK	0.87407932
49	MAP3K12	0.85266422
50	ERBB3	0.84307815
51	CSNK1G1	0.82505262
52	ATR	0.80858409
53	PLK2	0.77068668
54	BCR	0.75448186
55	PLK1	0.75073804
56	CSNK1G2	0.73712739
57	CAMKK2	0.73035199
58	INSRR	0.73034905
59	EIF2AK2	0.72686039
60	WEE1	0.68171768
61	ACVR1B	0.68051168
62	IKBKB	0.67077781
63	PAK3	0.65364682
64	ADRBK1	0.61229426
65	PRKCQ	0.60847527
66	PDK2	0.60662353
67	CSNK1A1L	0.60205568
68	PRKCG	0.59675266
69	KIT	0.58929237
70	RPS6KA5	0.58683685
71	PRKCE	0.56640888
72	PHKG1	0.55938286
73	PHKG2	0.55938286
74	TTK	0.53852509
75	GRK6	0.53298255
76	BRSK2	0.52153042
77	PIK3CA	0.51036219
78	BTK	0.49503156
79	DAPK2	0.49395588
80	AKT3	0.49240686
81	PNCK	0.48818106
82	AURKB	0.46715624
83	CSNK2A1	0.46194750
84	MAP2K6	0.45891857
85	CHEK2	0.44693715
86	PKN1	0.44224206
87	DYRK3	0.43001878
88	CSNK2A2	0.42760519
89	TGFBR1	0.40330600
90	PRKACA	0.39541495
91	IKBKE	0.39331169
92	RPS6KA4	0.39134147
93	GRK5	0.34082495
94	CSNK1A1	0.33886048
95	SYK	0.33000887
96	ATM	0.32990137
97	MAPKAPK5	0.32825596
98	FLT3	0.32414472
99	IGF1R	0.31708761
100	CSNK1E	0.30990981

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.79744997
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.14787297
3	Ribosome_Homo sapiens_hsa03010	3.01629998
4	RNA polymerase_Homo sapiens_hsa03020	2.84876563
5	Parkinsons disease_Homo sapiens_hsa05012	2.67939223
6	Protein export_Homo sapiens_hsa03060	2.48816481
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.36793943
8	Homologous recombination_Homo sapiens_hsa03440	2.29813873
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14366490
10	Basal transcription factors_Homo sapiens_hsa03022	2.11610013
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94947690
12	Asthma_Homo sapiens_hsa05310	1.89528983
13	Mismatch repair_Homo sapiens_hsa03430	1.89017897
14	Huntingtons disease_Homo sapiens_hsa05016	1.85390526
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.83552573
16	RNA degradation_Homo sapiens_hsa03018	1.83215667
17	One carbon pool by folate_Homo sapiens_hsa00670	1.79503560
18	Propanoate metabolism_Homo sapiens_hsa00640	1.74854842
19	Phototransduction_Homo sapiens_hsa04744	1.68926392
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.66176056
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.63622437
22	Alzheimers disease_Homo sapiens_hsa05010	1.58701634
23	Caffeine metabolism_Homo sapiens_hsa00232	1.53789569
24	RNA transport_Homo sapiens_hsa03013	1.53550917
25	Spliceosome_Homo sapiens_hsa03040	1.52267251
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.51572968
27	Allograft rejection_Homo sapiens_hsa05330	1.46260710
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.45358572
29	Base excision repair_Homo sapiens_hsa03410	1.45168629
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.43750874
31	Butanoate metabolism_Homo sapiens_hsa00650	1.42894009
32	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.42038254
33	DNA replication_Homo sapiens_hsa03030	1.40124257
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.39895844
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.39846165
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.36276001
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.35836494
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.34619646
39	Non-homologous end-joining_Homo sapiens_hsa03450	1.34251242
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.32745257
41	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30810022
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.21077884
43	Purine metabolism_Homo sapiens_hsa00230	1.19715088
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.19618919
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17593816
46	Type I diabetes mellitus_Homo sapiens_hsa04940	1.07707075
47	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.03392450
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.01751897
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00841709
50	Graft-versus-host disease_Homo sapiens_hsa05332	0.95906287
51	Olfactory transduction_Homo sapiens_hsa04740	0.94882135
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.94848422
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88674853
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.87979620
55	Peroxisome_Homo sapiens_hsa04146	0.86516875
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.85946970
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.78720611
58	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.75424873
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.72216696
60	Metabolic pathways_Homo sapiens_hsa01100	0.70396095
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.69193510
62	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.67293638
63	Taste transduction_Homo sapiens_hsa04742	0.66907173
64	Antigen processing and presentation_Homo sapiens_hsa04612	0.66854546
65	Pyruvate metabolism_Homo sapiens_hsa00620	0.66543886
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66320843
67	Retinol metabolism_Homo sapiens_hsa00830	0.63153180
68	Regulation of autophagy_Homo sapiens_hsa04140	0.62956744
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61936229
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61769835
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61735078
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60339563
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.58117654
74	Sulfur metabolism_Homo sapiens_hsa00920	0.57999291
75	Nicotine addiction_Homo sapiens_hsa05033	0.57328954
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57177968
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54657181
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54591525
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54454532
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52944908
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.51836328
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51686131
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50466105
84	Fatty acid elongation_Homo sapiens_hsa00062	0.49837323
85	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.44247633
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.43279647
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43269097
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43049780
89	mRNA surveillance pathway_Homo sapiens_hsa03015	0.40976883
90	Fatty acid degradation_Homo sapiens_hsa00071	0.40658436
91	Folate biosynthesis_Homo sapiens_hsa00790	0.40258865
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38796575
93	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.36226840
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.34821883
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.34216144
96	Histidine metabolism_Homo sapiens_hsa00340	0.30133356
97	Sulfur relay system_Homo sapiens_hsa04122	0.26667605
98	Cell cycle_Homo sapiens_hsa04110	0.25740761
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.24684854
100	p53 signaling pathway_Homo sapiens_hsa04115	0.24077091

HNRNPA1P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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