ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.05404477
2	rRNA modification (GO:0000154)	4.66725666
3	proteasome assembly (GO:0043248)	4.57097482
4	rRNA methylation (GO:0031167)	4.46413037
5	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.42018832
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.26626900
7	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.05219828
8	regulation of isotype switching to IgG isotypes (GO:0048302)	4.04618217
9	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.86908316
10	regulation of regulatory T cell differentiation (GO:0045589)	3.85210305
11	maturation of 5.8S rRNA (GO:0000460)	3.80878020
12	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.70439160
13	termination of RNA polymerase III transcription (GO:0006386)	3.70439160
14	ATP synthesis coupled proton transport (GO:0015986)	3.62536584
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.62536584
16	ribosome assembly (GO:0042255)	3.57812596
17	positive regulation of interleukin-17 production (GO:0032740)	3.46409724
18	pseudouridine synthesis (GO:0001522)	3.39735170
19	kinetochore assembly (GO:0051382)	3.37458595
20	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.34573105
21	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.33496356
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.33496356
23	positive regulation of protein homodimerization activity (GO:0090073)	3.28752278
24	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.27872052
25	fucose catabolic process (GO:0019317)	3.25815955
26	L-fucose metabolic process (GO:0042354)	3.25815955
27	L-fucose catabolic process (GO:0042355)	3.25815955
28	piRNA metabolic process (GO:0034587)	3.23791563
29	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.19689854
30	peptidyl-histidine modification (GO:0018202)	3.15288272
31	DNA catabolic process, exonucleolytic (GO:0000738)	3.10199759
32	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.08394176
33	nucleobase biosynthetic process (GO:0046112)	3.05626200
34	termination of RNA polymerase I transcription (GO:0006363)	3.00992965
35	chaperone-mediated protein transport (GO:0072321)	3.00863211
36	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.98412709
37	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.98303179
38	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.98261625
39	regulation of mitotic spindle checkpoint (GO:1903504)	2.98261625
40	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.98244083
41	tRNA processing (GO:0008033)	2.97278593
42	protein neddylation (GO:0045116)	2.95501121
43	transcription from mitochondrial promoter (GO:0006390)	2.94359045
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.92759910
45	NADH dehydrogenase complex assembly (GO:0010257)	2.92759910
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.92759910
47	mast cell degranulation (GO:0043303)	2.89376672
48	mast cell activation involved in immune response (GO:0002279)	2.89376672
49	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.88417717
50	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.88417717
51	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.88100932
52	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.88100932
53	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.88100932
54	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.86768657
55	ribosomal large subunit biogenesis (GO:0042273)	2.86366668
56	protein deneddylation (GO:0000338)	2.86300385
57	mitochondrial RNA metabolic process (GO:0000959)	2.85935427
58	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.85642463
59	negative regulation of B cell apoptotic process (GO:0002903)	2.85331480
60	tRNA metabolic process (GO:0006399)	2.84250678
61	platelet dense granule organization (GO:0060155)	2.84125938
62	regulation of cellular amino acid metabolic process (GO:0006521)	2.78821610
63	ribosome biogenesis (GO:0042254)	2.77616061
64	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.77490487
65	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.77490487
66	ribosomal small subunit assembly (GO:0000028)	2.77077000
67	interferon-gamma production (GO:0032609)	2.76197003
68	L-methionine salvage (GO:0071267)	2.75181285
69	L-methionine biosynthetic process (GO:0071265)	2.75181285
70	amino acid salvage (GO:0043102)	2.75181285
71	mitochondrial respiratory chain complex assembly (GO:0033108)	2.71880677
72	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.71283434
73	cullin deneddylation (GO:0010388)	2.71280739
74	regulation of immunoglobulin secretion (GO:0051023)	2.70721275
75	protein complex biogenesis (GO:0070271)	2.70676702
76	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.69912254
77	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.69912254
78	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.68915642
79	rRNA metabolic process (GO:0016072)	2.64516797
80	rRNA processing (GO:0006364)	2.64159350
81	cellular response to exogenous dsRNA (GO:0071360)	2.63280244
82	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.61833440
83	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.61664655
84	kinetochore organization (GO:0051383)	2.60401388
85	purine nucleobase biosynthetic process (GO:0009113)	2.60358127
86	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.59913410
87	ncRNA metabolic process (GO:0034660)	2.57868528
88	protein targeting to mitochondrion (GO:0006626)	2.57829443
89	respiratory chain complex IV assembly (GO:0008535)	2.57102419
90	cellular response to interferon-beta (GO:0035458)	2.56889958
91	intra-S DNA damage checkpoint (GO:0031573)	2.56672368
92	positive regulation of isotype switching (GO:0045830)	2.56389895
93	positive regulation of DNA recombination (GO:0045911)	2.55642925
94	spliceosomal snRNP assembly (GO:0000387)	2.55563755
95	mast cell activation (GO:0045576)	2.53299354
96	ubiquinone biosynthetic process (GO:0006744)	2.52958430
97	preassembly of GPI anchor in ER membrane (GO:0016254)	2.52867954
98	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.52259940
99	rRNA catabolic process (GO:0016075)	2.51764304
100	negative regulation of ligase activity (GO:0051352)	2.51718640

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.46664873
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.20949824
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.64931905
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.47995345
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.08634021
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.07614945
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.01007839
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.88021895
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.78175254
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.75845303
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.51691034
12	VDR_22108803_ChIP-Seq_LS180_Human	2.44389601
13	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.39491545
14	FOXP3_21729870_ChIP-Seq_TREG_Human	2.37987510
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.37015693
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.35867553
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.26145396
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.25892141
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.24148032
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.16863385
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.15136043
22	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.14429999
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.13734345
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.03799193
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.96531674
26	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.92950723
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.85407384
28	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.83964367
29	IGF1R_20145208_ChIP-Seq_DFB_Human	1.80586448
30	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.78386964
31	EWS_26573619_Chip-Seq_HEK293_Human	1.78272329
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.73672322
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.66670508
34	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.66095299
35	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.63692427
36	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.62312840
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.56270074
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.56135219
39	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.55359554
40	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.52130617
41	TTF2_22483619_ChIP-Seq_HELA_Human	1.51954051
42	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47860381
43	GATA3_26560356_Chip-Seq_TH2_Human	1.47296913
44	E2F7_22180533_ChIP-Seq_HELA_Human	1.45723507
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.45331533
46	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.45109488
47	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.42034585
48	GABP_19822575_ChIP-Seq_HepG2_Human	1.41712776
49	FUS_26573619_Chip-Seq_HEK293_Human	1.41326828
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40838723
51	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.39023082
52	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.36421427
53	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.35409606
54	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.35283670
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30233526
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28928828
57	TAF15_26573619_Chip-Seq_HEK293_Human	1.26685563
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24874210
59	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.24796251
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23017675
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23017675
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22491826
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22491826
64	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.19531117
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.19124504
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.17827413
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15902477
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15359379
69	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.14844907
70	AR_20517297_ChIP-Seq_VCAP_Human	1.13461252
71	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.10442340
72	MYB_26560356_Chip-Seq_TH2_Human	1.09384106
73	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09152625
74	NCOR_22424771_ChIP-Seq_293T_Human	1.08912863
75	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08634072
76	CBP_20019798_ChIP-Seq_JUKART_Human	1.05440702
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05440702
78	IRF1_19129219_ChIP-ChIP_H3396_Human	1.04427133
79	P300_19829295_ChIP-Seq_ESCs_Human	1.02950705
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02497795
81	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.02169681
82	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.01172891
83	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.97820827
84	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.94930705
85	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94848841
86	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.94098315
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93436800
88	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.93096053
89	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.92700464
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.90439752
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.89596513
92	RBPJ_21746931_ChIP-Seq_IB4_Human	0.89386634
93	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.89139569
94	CIITA_25753668_ChIP-Seq_RAJI_Human	0.88579073
95	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88189166
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.87767187
97	GATA3_27048872_Chip-Seq_THYMUS_Human	0.87708504
98	SPI1_23547873_ChIP-Seq_NB4_Human	0.87244976
99	XRN2_22483619_ChIP-Seq_HELA_Human	0.86552509
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86055635

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	3.93187818
2	MP0004147_increased_porphyrin_level	3.90282764
3	MP0003806_abnormal_nucleotide_metabolis	3.27432675
4	MP0005671_abnormal_response_to	2.69690163
5	MP0002102_abnormal_ear_morphology	2.48612841
6	MP0008877_abnormal_DNA_methylation	2.39659527
7	MP0009697_abnormal_copulation	2.38847901
8	MP0003195_calcinosis	2.37738690
9	MP0003786_premature_aging	2.35445158
10	MP0008875_abnormal_xenobiotic_pharmacok	2.33908683
11	MP0008058_abnormal_DNA_repair	2.33879233
12	MP0008872_abnormal_physiological_respon	2.22421068
13	MP0002138_abnormal_hepatobiliary_system	2.21505114
14	MP0002148_abnormal_hypersensitivity_rea	2.14753894
15	MP0006072_abnormal_retinal_apoptosis	2.11033539
16	MP0004885_abnormal_endolymph	2.05649968
17	MP0003718_maternal_effect	1.97025600
18	MP0003693_abnormal_embryo_hatching	1.95100731
19	MP0004145_abnormal_muscle_electrophysio	1.85303851
20	MP0006036_abnormal_mitochondrial_physio	1.81767519
21	MP0001800_abnormal_humoral_immune	1.79743703
22	MP0005387_immune_system_phenotype	1.76955024
23	MP0001790_abnormal_immune_system	1.76955024
24	MP0001986_abnormal_taste_sensitivity	1.69813679
25	MP0006035_abnormal_mitochondrial_morpho	1.65015351
26	MP0005000_abnormal_immune_tolerance	1.65014835
27	MP0005377_hearing/vestibular/ear_phenot	1.64719819
28	MP0003878_abnormal_ear_physiology	1.64719819
29	MP0010094_abnormal_chromosome_stability	1.63957070
30	MP0005551_abnormal_eye_electrophysiolog	1.61547681
31	MP0005075_abnormal_melanosome_morpholog	1.58693870
32	MP0002006_tumorigenesis	1.56695348
33	MP0000685_abnormal_immune_system	1.54278137
34	MP0001968_abnormal_touch/_nociception	1.52791983
35	MP0002723_abnormal_immune_serum	1.47909305
36	MP0002736_abnormal_nociception_after	1.42439454
37	MP0003763_abnormal_thymus_physiology	1.42092997
38	MP0003646_muscle_fatigue	1.41477321
39	MP0000372_irregular_coat_pigmentation	1.36894904
40	MP0009333_abnormal_splenocyte_physiolog	1.35611520
41	MP0002452_abnormal_antigen_presenting	1.34642987
42	MP0000465_gastrointestinal_hemorrhage	1.32102962
43	MP0002876_abnormal_thyroid_physiology	1.29106739
44	MP0008775_abnormal_heart_ventricle	1.28530773
45	MP0001188_hyperpigmentation	1.26911603
46	MP0001819_abnormal_immune_cell	1.26624358
47	MP0005646_abnormal_pituitary_gland	1.25659638
48	MP0002420_abnormal_adaptive_immunity	1.24540512
49	MP0004957_abnormal_blastocyst_morpholog	1.23923558
50	MP0005085_abnormal_gallbladder_physiolo	1.20049341
51	MP0001764_abnormal_homeostasis	1.19274326
52	MP0009785_altered_susceptibility_to	1.17851796
53	MP0002398_abnormal_bone_marrow	1.15885376
54	MP0003866_abnormal_defecation	1.15689357
55	MP0003186_abnormal_redox_activity	1.11635249
56	MP0001873_stomach_inflammation	1.09716004
57	MP0002139_abnormal_hepatobiliary_system	1.09574541
58	MP0001919_abnormal_reproductive_system	1.08673406
59	MP0001501_abnormal_sleep_pattern	1.08120991
60	MP0003436_decreased_susceptibility_to	1.07472971
61	MP0002277_abnormal_respiratory_mucosa	1.06663078
62	MP0005084_abnormal_gallbladder_morpholo	1.05348981
63	MP0000689_abnormal_spleen_morphology	1.04931701
64	MP0003567_abnormal_fetal_cardiomyocyte	1.04775846
65	MP0005389_reproductive_system_phenotype	1.02241188
66	MP0001853_heart_inflammation	1.01554761
67	MP0005253_abnormal_eye_physiology	1.01155595
68	MP0004036_abnormal_muscle_relaxation	0.99922191
69	MP0000427_abnormal_hair_cycle	0.97698226
70	MP0001661_extended_life_span	0.96579188
71	MP0000716_abnormal_immune_system	0.96551649
72	MP0006292_abnormal_olfactory_placode	0.95012506
73	MP0003724_increased_susceptibility_to	0.92144594
74	MP0002429_abnormal_blood_cell	0.91242525
75	MP0000358_abnormal_cell_content/	0.91064200
76	MP0004782_abnormal_surfactant_physiolog	0.90842882
77	MP0008995_early_reproductive_senescence	0.89852022
78	MP0002234_abnormal_pharynx_morphology	0.89636136
79	MP0001845_abnormal_inflammatory_respons	0.88092264
80	MP0005310_abnormal_salivary_gland	0.87348996
81	MP0002166_altered_tumor_susceptibility	0.84551827
82	MP0002938_white_spotting	0.84323260
83	MP0009764_decreased_sensitivity_to	0.84115682
84	MP0005332_abnormal_amino_acid	0.82629456
85	MP0005025_abnormal_response_to	0.81657544
86	MP0001905_abnormal_dopamine_level	0.80523306
87	MP0006054_spinal_hemorrhage	0.80497833
88	MP0005645_abnormal_hypothalamus_physiol	0.80406102
89	MP0001984_abnormal_olfaction	0.79478427
90	MP0002405_respiratory_system_inflammati	0.78868011
91	MP0005410_abnormal_fertilization	0.78865204
92	MP0005174_abnormal_tail_pigmentation	0.77578901
93	MP0002837_dystrophic_cardiac_calcinosis	0.77134253
94	MP0005636_abnormal_mineral_homeostasis	0.77126545
95	MP0002722_abnormal_immune_system	0.76666987
96	MP0001727_abnormal_embryo_implantation	0.76448799
97	MP0008007_abnormal_cellular_replicative	0.76428410
98	MP0001929_abnormal_gametogenesis	0.75910468
99	MP0000703_abnormal_thymus_morphology	0.75847751
100	MP0004084_abnormal_cardiac_muscle	0.72980948

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.14804327
2	Methylmalonic acidemia (HP:0002912)	3.66436803
3	Stomatitis (HP:0010280)	3.62992813
4	Acute necrotizing encephalopathy (HP:0006965)	3.54408689
5	Molar tooth sign on MRI (HP:0002419)	3.50127522
6	Abnormality of midbrain morphology (HP:0002418)	3.50127522
7	IgG deficiency (HP:0004315)	3.46616034
8	B lymphocytopenia (HP:0010976)	3.37800240
9	Abnormality of B cell number (HP:0010975)	3.37112490
10	Acute encephalopathy (HP:0006846)	3.31536950
11	Pancreatic cysts (HP:0001737)	3.20181868
12	Mitochondrial inheritance (HP:0001427)	3.19606506
13	Increased CSF lactate (HP:0002490)	3.12694689
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.12472794
15	Nephronophthisis (HP:0000090)	3.11939144
16	Progressive macrocephaly (HP:0004481)	2.87888631
17	Severe combined immunodeficiency (HP:0004430)	2.83889505
18	Attenuation of retinal blood vessels (HP:0007843)	2.83596125
19	Type 2 muscle fiber atrophy (HP:0003554)	2.75784460
20	Increased serum lactate (HP:0002151)	2.70424696
21	Abnormality of eosinophils (HP:0001879)	2.67963595
22	Pancreatic fibrosis (HP:0100732)	2.66832974
23	Methylmalonic aciduria (HP:0012120)	2.64841720
24	Lipid accumulation in hepatocytes (HP:0006561)	2.62553930
25	Increased hepatocellular lipid droplets (HP:0006565)	2.60439213
26	Panhypogammaglobulinemia (HP:0003139)	2.59449238
27	Cerebral edema (HP:0002181)	2.53652746
28	Abnormality of the pons (HP:0007361)	2.52875508
29	Elevated erythrocyte sedimentation rate (HP:0003565)	2.52852664
30	True hermaphroditism (HP:0010459)	2.50017469
31	Hypoproteinemia (HP:0003075)	2.48658958
32	Hepatocellular necrosis (HP:0001404)	2.48614450
33	Bile duct proliferation (HP:0001408)	2.46526892
34	Abnormal biliary tract physiology (HP:0012439)	2.46526892
35	Constricted visual fields (HP:0001133)	2.44113563
36	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.43609547
37	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.43257016
38	Muscle fiber atrophy (HP:0100295)	2.42435107
39	Abnormality of the renal medulla (HP:0100957)	2.41269387
40	Neoplasm of the adrenal cortex (HP:0100641)	2.39645286
41	Hepatic necrosis (HP:0002605)	2.37229367
42	Optic disc pallor (HP:0000543)	2.37119193
43	Lethargy (HP:0001254)	2.35597471
44	Abnormality of the renal cortex (HP:0011035)	2.35085856
45	Thyroiditis (HP:0100646)	2.33027359
46	Testicular atrophy (HP:0000029)	2.32917581
47	Eosinophilia (HP:0001880)	2.32533518
48	Microvesicular hepatic steatosis (HP:0001414)	2.29617125
49	Abnormality of vitamin B metabolism (HP:0004340)	2.29592977
50	Type I transferrin isoform profile (HP:0003642)	2.29566551
51	Dicarboxylic aciduria (HP:0003215)	2.26272546
52	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.26272546
53	Lactic acidosis (HP:0003128)	2.22606862
54	Megaloblastic anemia (HP:0001889)	2.22395509
55	Abolished electroretinogram (ERG) (HP:0000550)	2.21337548
56	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.20538282
57	Renal cortical cysts (HP:0000803)	2.20426761
58	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.19776804
59	Increased intramyocellular lipid droplets (HP:0012240)	2.18125850
60	Combined immunodeficiency (HP:0005387)	2.16333458
61	Hyperglycinuria (HP:0003108)	2.15535131
62	Colon cancer (HP:0003003)	2.14971815
63	Congenital stationary night blindness (HP:0007642)	2.14450034
64	Pancytopenia (HP:0001876)	2.12607688
65	Pendular nystagmus (HP:0012043)	2.12029156
66	Congenital, generalized hypertrichosis (HP:0004540)	2.11991850
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.11524807
68	Hypoplasia of the pons (HP:0012110)	2.11419024
69	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.08572822
70	Abnormality of alanine metabolism (HP:0010916)	2.08572822
71	Hyperalaninemia (HP:0003348)	2.08572822
72	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.04270151
73	Meckel diverticulum (HP:0002245)	2.03576793
74	Medial flaring of the eyebrow (HP:0010747)	2.00930075
75	Opisthotonus (HP:0002179)	2.00291968
76	Abnormality of serum amino acid levels (HP:0003112)	1.99509189
77	Reduced antithrombin III activity (HP:0001976)	1.98331685
78	Abnormality of the ileum (HP:0001549)	1.97987767
79	Increased muscle lipid content (HP:0009058)	1.97502164
80	Abnormality of the prostate (HP:0008775)	1.96945610
81	Chronic otitis media (HP:0000389)	1.96390630
82	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.93277180
83	Abnormal protein N-linked glycosylation (HP:0012347)	1.93277180
84	Abnormal protein glycosylation (HP:0012346)	1.93277180
85	Abnormal glycosylation (HP:0012345)	1.93277180
86	Stomach cancer (HP:0012126)	1.92797039
87	Abnormality of T cells (HP:0002843)	1.90846173
88	Type II lissencephaly (HP:0007260)	1.88988814
89	Abnormality of T cell physiology (HP:0011840)	1.87923469
90	Abnormality of the preputium (HP:0100587)	1.87864973
91	Abnormality of glycine metabolism (HP:0010895)	1.86601463
92	Abnormality of serine family amino acid metabolism (HP:0010894)	1.86601463
93	Hypothermia (HP:0002045)	1.83707057
94	Exercise intolerance (HP:0003546)	1.82580540
95	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.82051925
96	Abnormal rod and cone electroretinograms (HP:0008323)	1.81804316
97	Abnormality of methionine metabolism (HP:0010901)	1.81649675
98	Encephalitis (HP:0002383)	1.81349709
99	Exertional dyspnea (HP:0002875)	1.77545509
100	Abnormality of homocysteine metabolism (HP:0010919)	1.77217333

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.90753377
2	ZAK	3.45359970
3	TSSK6	3.33796224
4	MAP4K2	3.22194710
5	EIF2AK3	2.91790192
6	TXK	2.74856517
7	NEK1	2.70934673
8	VRK2	2.65756114
9	TLK1	2.60744650
10	NUAK1	2.59200388
11	EIF2AK1	2.48690234
12	MKNK1	2.40626352
13	MAP4K1	2.26013035
14	TEC	2.24563794
15	MST4	2.15385764
16	PBK	1.92401074
17	KIT	1.91611958
18	TRIM28	1.80753676
19	MAP3K12	1.78665914
20	ITK	1.73583000
21	ADRBK2	1.71550084
22	PLK3	1.67444682
23	VRK1	1.58709103
24	GRK1	1.58226390
25	TAF1	1.53761167
26	SRPK1	1.49383980
27	BCKDK	1.34914947
28	BUB1	1.21394449
29	NME1	1.14847130
30	EIF2AK2	1.13248560
31	BTK	1.10917556
32	MATK	1.10484634
33	PIK3CG	1.09319548
34	CDC7	1.04118203
35	FRK	1.03588058
36	MKNK2	1.00788295
37	WNK3	1.00489389
38	PASK	0.96411094
39	TIE1	0.96229740
40	WNK4	0.94897041
41	SIK3	0.92800617
42	MAPKAPK5	0.89011750
43	STK16	0.86433323
44	CSNK1G1	0.84924186
45	SYK	0.84418576
46	FES	0.84219710
47	ATR	0.82347436
48	IKBKB	0.79781967
49	PLK4	0.77717020
50	BMPR1B	0.77521721
51	LCK	0.77384658
52	ALK	0.76725616
53	PRKCQ	0.75276365
54	RPS6KA5	0.73503529
55	CSNK1G3	0.70441511
56	DYRK2	0.70378522
57	GRK6	0.69871795
58	CSNK1A1L	0.69522671
59	PLK2	0.68765735
60	MAP2K6	0.67726268
61	MAPKAPK3	0.65416261
62	JAK3	0.64163423
63	PINK1	0.64105364
64	DAPK1	0.63955278
65	FLT3	0.61747142
66	OXSR1	0.60290177
67	RIPK4	0.59668201
68	SCYL2	0.59564088
69	LYN	0.58491283
70	CSNK1G2	0.58463578
71	BRSK2	0.58096294
72	PLK1	0.56763275
73	ADRBK1	0.56336620
74	NME2	0.54684392
75	CSF1R	0.53672214
76	IGF1R	0.51654919
77	ACVR1B	0.49547560
78	AURKB	0.49083613
79	CAMKK2	0.47167793
80	PRKCE	0.43973736
81	RPS6KB2	0.42414761
82	TNIK	0.41821495
83	MAP3K5	0.41646649
84	PHKG2	0.40564835
85	PHKG1	0.40564835
86	INSRR	0.40480826
87	MAPK7	0.40282145
88	CSNK2A1	0.40244481
89	IKBKE	0.39878733
90	TTK	0.39624680
91	ERBB3	0.38373349
92	MYLK	0.35934526
93	PIM1	0.35610311
94	ATM	0.35472086
95	CSNK2A2	0.32723122
96	GRK5	0.32460398
97	STK39	0.32348670
98	MAP3K14	0.30979846
99	HCK	0.30565892
100	BCR	0.26281145

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.76585685
2	RNA polymerase_Homo sapiens_hsa03020	3.03937551
3	Protein export_Homo sapiens_hsa03060	2.94008274
4	Asthma_Homo sapiens_hsa05310	2.91351304
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.86739870
6	Allograft rejection_Homo sapiens_hsa05330	2.72635276
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.71191428
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.48949606
9	Basal transcription factors_Homo sapiens_hsa03022	2.20902129
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.17400721
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.07198425
12	Ribosome_Homo sapiens_hsa03010	2.06918969
13	Graft-versus-host disease_Homo sapiens_hsa05332	2.05492005
14	Primary immunodeficiency_Homo sapiens_hsa05340	2.00122372
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.99893446
16	Homologous recombination_Homo sapiens_hsa03440	1.93879223
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.86025345
18	RNA degradation_Homo sapiens_hsa03018	1.84158519
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.76326301
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.76202288
21	Parkinsons disease_Homo sapiens_hsa05012	1.72201959
22	One carbon pool by folate_Homo sapiens_hsa00670	1.70974010
23	Mismatch repair_Homo sapiens_hsa03430	1.68284113
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.65067569
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.64317838
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.61970650
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.61900010
28	Propanoate metabolism_Homo sapiens_hsa00640	1.58036783
29	RNA transport_Homo sapiens_hsa03013	1.57846000
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.54173137
31	Spliceosome_Homo sapiens_hsa03040	1.52369802
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45260868
33	DNA replication_Homo sapiens_hsa03030	1.40503233
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.38918141
35	Purine metabolism_Homo sapiens_hsa00230	1.37658753
36	Phototransduction_Homo sapiens_hsa04744	1.36747056
37	Base excision repair_Homo sapiens_hsa03410	1.34297497
38	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.30765094
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.19869042
40	Antigen processing and presentation_Homo sapiens_hsa04612	1.16934998
41	Regulation of autophagy_Homo sapiens_hsa04140	1.15471171
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.08381121
43	Huntingtons disease_Homo sapiens_hsa05016	1.05894661
44	Sulfur metabolism_Homo sapiens_hsa00920	1.05722499
45	Linoleic acid metabolism_Homo sapiens_hsa00591	1.04816264
46	Tryptophan metabolism_Homo sapiens_hsa00380	1.04497616
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.01029377
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97950067
49	Caffeine metabolism_Homo sapiens_hsa00232	0.95170751
50	Nitrogen metabolism_Homo sapiens_hsa00910	0.91728797
51	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.90532280
52	Alzheimers disease_Homo sapiens_hsa05010	0.86274883
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.86062803
54	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.83972840
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.82799084
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.79659087
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.78429942
58	Circadian rhythm_Homo sapiens_hsa04710	0.76769629
59	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.73176653
60	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.71319349
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.69924229
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.69028969
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.68195672
64	Peroxisome_Homo sapiens_hsa04146	0.66152610
65	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65810449
66	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.65504247
67	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.62855737
68	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.62538542
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.60421354
70	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.57260307
71	Butanoate metabolism_Homo sapiens_hsa00650	0.56448473
72	Metabolic pathways_Homo sapiens_hsa01100	0.55088717
73	Herpes simplex infection_Homo sapiens_hsa05168	0.54541330
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53210331
75	Measles_Homo sapiens_hsa05162	0.49984631
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.49908819
77	Fatty acid elongation_Homo sapiens_hsa00062	0.47161922
78	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.47111784
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45592557
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.44921117
81	Olfactory transduction_Homo sapiens_hsa04740	0.44630593
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44153386
83	Fatty acid degradation_Homo sapiens_hsa00071	0.42293348
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38281810
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.38030291
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.34476235
87	Retinol metabolism_Homo sapiens_hsa00830	0.34028899
88	Viral myocarditis_Homo sapiens_hsa05416	0.33813499
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32948027
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32043000
91	Collecting duct acid secretion_Homo sapiens_hsa04966	0.31471755
92	ABC transporters_Homo sapiens_hsa02010	0.30868503
93	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.30274528
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.29598686
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.25303453
96	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.25117809
97	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.24884198
98	Cardiac muscle contraction_Homo sapiens_hsa04260	0.24848044
99	p53 signaling pathway_Homo sapiens_hsa04115	0.24407167
100	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.21485714

HNRNPA1P60

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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