ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	7.49423036
2	DNA deamination (GO:0045006)	6.59421298
3	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.82499372
4	ATP synthesis coupled proton transport (GO:0015986)	4.67780411
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.67780411
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.57706672
7	cytidine deamination (GO:0009972)	4.54941887
8	cytidine metabolic process (GO:0046087)	4.54941887
9	cytidine catabolic process (GO:0006216)	4.54941887
10	ribosomal small subunit assembly (GO:0000028)	4.39286402
11	chaperone-mediated protein transport (GO:0072321)	4.22373764
12	protein deneddylation (GO:0000338)	4.10895538
13	platelet dense granule organization (GO:0060155)	4.03019394
14	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.80588659
15	water-soluble vitamin biosynthetic process (GO:0042364)	3.78572901
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.56528214
17	protein complex biogenesis (GO:0070271)	3.54722130
18	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.50343475
19	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.49822274
20	NADH dehydrogenase complex assembly (GO:0010257)	3.49822274
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.49822274
22	base-excision repair, AP site formation (GO:0006285)	3.46598658
23	cullin deneddylation (GO:0010388)	3.40773283
24	GPI anchor metabolic process (GO:0006505)	3.31841797
25	sequestering of actin monomers (GO:0042989)	3.24404273
26	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.22924226
27	mitochondrial respiratory chain complex assembly (GO:0033108)	3.17261202
28	protein neddylation (GO:0045116)	3.07707124
29	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.07589275
30	GPI anchor biosynthetic process (GO:0006506)	3.04527133
31	electron transport chain (GO:0022900)	2.99485575
32	respiratory chain complex IV assembly (GO:0008535)	2.96479491
33	cellular response to interleukin-15 (GO:0071350)	2.95678390
34	respiratory electron transport chain (GO:0022904)	2.95160041
35	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.94426737
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.94177807
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.94177807
38	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.94067904
39	cytochrome complex assembly (GO:0017004)	2.93241582
40	resolution of meiotic recombination intermediates (GO:0000712)	2.93158666
41	proteasome assembly (GO:0043248)	2.92422793
42	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.90389514
43	GTP biosynthetic process (GO:0006183)	2.89465641
44	regulation of regulatory T cell differentiation (GO:0045589)	2.83919790
45	adenosine metabolic process (GO:0046085)	2.82651793
46	regulation of isotype switching to IgG isotypes (GO:0048302)	2.79322205
47	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.75771899
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.73170491
49	behavioral response to nicotine (GO:0035095)	2.71911793
50	ATP biosynthetic process (GO:0006754)	2.71447559
51	deoxyribonucleotide catabolic process (GO:0009264)	2.70453536
52	preassembly of GPI anchor in ER membrane (GO:0016254)	2.70268103
53	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.69886522
54	regulation of mitotic spindle checkpoint (GO:1903504)	2.68964625
55	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.68964625
56	deoxyribose phosphate catabolic process (GO:0046386)	2.67478471
57	cotranslational protein targeting to membrane (GO:0006613)	2.66379283
58	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.65126592
59	purine deoxyribonucleotide catabolic process (GO:0009155)	2.65104139
60	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.62185456
61	maturation of SSU-rRNA (GO:0030490)	2.61445352
62	protein targeting to ER (GO:0045047)	2.61047411
63	negative regulation by host of viral transcription (GO:0043922)	2.60488438
64	viral transcription (GO:0019083)	2.59027832
65	regulation of memory T cell differentiation (GO:0043380)	2.58777827
66	regulation of immunoglobulin secretion (GO:0051023)	2.56674175
67	aldehyde catabolic process (GO:0046185)	2.55698990
68	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.54926910
69	translational termination (GO:0006415)	2.54457457
70	translational elongation (GO:0006414)	2.54123752
71	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.53926028
72	regulation of cellular amino acid metabolic process (GO:0006521)	2.53537316
73	positive regulation of activated T cell proliferation (GO:0042104)	2.51495713
74	regulation of T cell receptor signaling pathway (GO:0050856)	2.51258618
75	UTP metabolic process (GO:0046051)	2.51042235
76	positive regulation of interleukin-17 production (GO:0032740)	2.50111985
77	mannosylation (GO:0097502)	2.47393817
78	negative regulation of mast cell activation (GO:0033004)	2.45729709
79	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.43876136
80	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.43792114
81	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.43023397
82	positive regulation of prostaglandin secretion (GO:0032308)	2.42770065
83	protein localization to endoplasmic reticulum (GO:0070972)	2.42499187
84	urate metabolic process (GO:0046415)	2.41024397
85	pseudouridine synthesis (GO:0001522)	2.40694939
86	translation (GO:0006412)	2.40567520
87	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.39568517
88	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.39251249
89	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.39216346
90	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.39216346
91	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.39216346
92	UTP biosynthetic process (GO:0006228)	2.37208474
93	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.36208130
94	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.36127732
95	isotype switching (GO:0045190)	2.36127732
96	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.36127732
97	regulation of triglyceride catabolic process (GO:0010896)	2.36076757
98	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.34453673
99	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.34453673
100	chromatin remodeling at centromere (GO:0031055)	2.33700050

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.14957233
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.84634672
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.70919162
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.15359650
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.85805204
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.80810487
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.77317048
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.75760254
9	VDR_22108803_ChIP-Seq_LS180_Human	2.70155950
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.61011156
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.55685251
12	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.54047956
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.44523276
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.39516503
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.39220632
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.22186319
17	EWS_26573619_Chip-Seq_HEK293_Human	2.20976466
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.14335433
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.14183598
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.07771897
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.06885914
22	FOXP3_21729870_ChIP-Seq_TREG_Human	2.00857211
23	TAF15_26573619_Chip-Seq_HEK293_Human	2.00744217
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.94547851
25	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.87726640
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.86895906
27	IGF1R_20145208_ChIP-Seq_DFB_Human	1.84228697
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.71270852
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.69175960
30	FUS_26573619_Chip-Seq_HEK293_Human	1.68239732
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67891806
32	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.67165487
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.64612882
34	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.61086907
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.60278443
36	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.57205939
37	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.52790897
38	P300_19829295_ChIP-Seq_ESCs_Human	1.49490851
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48741426
40	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.46496536
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44895327
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44895327
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.42780650
44	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42247238
45	EZH2_22144423_ChIP-Seq_EOC_Human	1.40989400
46	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.38217321
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36742273
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36742273
49	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.36328955
50	AR_20517297_ChIP-Seq_VCAP_Human	1.35481395
51	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.35280218
52	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.31710964
53	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.31319789
54	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.30175926
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29421721
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27947637
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.26878398
58	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.26448310
59	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.24917423
60	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.23168638
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21621922
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20878373
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18879303
64	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.18663834
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18541388
66	GATA3_26560356_Chip-Seq_TH2_Human	1.18281396
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17193009
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.17193009
69	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17042679
70	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.16625664
71	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.16240492
72	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15739437
73	MYB_26560356_Chip-Seq_TH2_Human	1.14183871
74	ER_23166858_ChIP-Seq_MCF-7_Human	1.13902710
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12592660
76	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10912385
77	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.10054125
78	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.09275771
79	ERG_20517297_ChIP-Seq_VCAP_Human	1.06966544
80	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.05257681
81	NCOR_22424771_ChIP-Seq_293T_Human	1.04812728
82	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.04507108
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04232315
84	TTF2_22483619_ChIP-Seq_HELA_Human	1.02637563
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01635664
86	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01233738
87	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.98659216
88	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.98412349
89	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98239635
90	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.96071864
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94973160
92	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.94748657
93	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.94666373
94	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94089969
95	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.93874210
96	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.93794555
97	GABP_19822575_ChIP-Seq_HepG2_Human	0.93021335
98	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.90981124
99	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.89715465
100	DCP1A_22483619_ChIP-Seq_HELA_Human	0.89675751

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.32127150
2	MP0006292_abnormal_olfactory_placode	2.86359341
3	MP0001835_abnormal_antigen_presentation	2.76729349
4	MP0006072_abnormal_retinal_apoptosis	2.76187493
5	MP0009785_altered_susceptibility_to	2.57363605
6	MP0008872_abnormal_physiological_respon	2.49960940
7	MP0008875_abnormal_xenobiotic_pharmacok	2.40965367
8	MP0005084_abnormal_gallbladder_morpholo	2.35682524
9	MP0002102_abnormal_ear_morphology	2.26940852
10	MP0003195_calcinosis	2.14148753
11	MP0008877_abnormal_DNA_methylation	2.12725203
12	MP0009333_abnormal_splenocyte_physiolog	2.11191578
13	MP0004147_increased_porphyrin_level	2.07794343
14	MP0005645_abnormal_hypothalamus_physiol	1.85787407
15	MP0003283_abnormal_digestive_organ	1.74180169
16	MP0002736_abnormal_nociception_after	1.71133282
17	MP0002277_abnormal_respiratory_mucosa	1.69875805
18	MP0002148_abnormal_hypersensitivity_rea	1.67862825
19	MP0005000_abnormal_immune_tolerance	1.66438206
20	MP0005551_abnormal_eye_electrophysiolog	1.65848253
21	MP0005085_abnormal_gallbladder_physiolo	1.62210777
22	MP0002166_altered_tumor_susceptibility	1.61949054
23	MP0001800_abnormal_humoral_immune	1.59854721
24	MP0009379_abnormal_foot_pigmentation	1.54545296
25	MP0001529_abnormal_vocalization	1.45901977
26	MP0002163_abnormal_gland_morphology	1.45456905
27	MP0001968_abnormal_touch/_nociception	1.45103529
28	MP0003806_abnormal_nucleotide_metabolis	1.44711602
29	MP0002723_abnormal_immune_serum	1.43549004
30	MP0003786_premature_aging	1.39561005
31	MP0005646_abnormal_pituitary_gland	1.38618246
32	MP0005377_hearing/vestibular/ear_phenot	1.37970480
33	MP0003878_abnormal_ear_physiology	1.37970480
34	MP0002138_abnormal_hepatobiliary_system	1.37860629
35	MP0001919_abnormal_reproductive_system	1.35340406
36	MP0003763_abnormal_thymus_physiology	1.35091130
37	MP0002006_tumorigenesis	1.34211305
38	MP0003011_delayed_dark_adaptation	1.33290414
39	MP0005253_abnormal_eye_physiology	1.29207283
40	MP0005410_abnormal_fertilization	1.26984769
41	MP0002234_abnormal_pharynx_morphology	1.25057877
42	MP0001873_stomach_inflammation	1.24003349
43	MP0005379_endocrine/exocrine_gland_phen	1.22555352
44	MP0002876_abnormal_thyroid_physiology	1.21941579
45	MP0002420_abnormal_adaptive_immunity	1.20026834
46	MP0003693_abnormal_embryo_hatching	1.19334056
47	MP0001819_abnormal_immune_cell	1.18732470
48	MP0004043_abnormal_pH_regulation	1.18649721
49	MP0005025_abnormal_response_to	1.18252329
50	MP0001986_abnormal_taste_sensitivity	1.16523058
51	MP0002405_respiratory_system_inflammati	1.15535709
52	MP0005389_reproductive_system_phenotype	1.15068232
53	MP0002653_abnormal_ependyma_morphology	1.14973854
54	MP0001905_abnormal_dopamine_level	1.13304371
55	MP0009697_abnormal_copulation	1.09546729
56	MP0010155_abnormal_intestine_physiology	1.09367896
57	MP0002452_abnormal_antigen_presenting	1.08726654
58	MP0001790_abnormal_immune_system	1.04891882
59	MP0005387_immune_system_phenotype	1.04891882
60	MP0001293_anophthalmia	1.04534486
61	MP0003567_abnormal_fetal_cardiomyocyte	1.04363214
62	MP0000049_abnormal_middle_ear	1.03977570
63	MP0008058_abnormal_DNA_repair	1.01873260
64	MP0003787_abnormal_imprinting	1.00154600
65	MP0003866_abnormal_defecation	0.99704561
66	MP0001845_abnormal_inflammatory_respons	0.99121312
67	MP0000372_irregular_coat_pigmentation	0.98916169
68	MP0000716_abnormal_immune_system	0.97939988
69	MP0008995_early_reproductive_senescence	0.97343852
70	MP0003252_abnormal_bile_duct	0.95679513
71	MP0009764_decreased_sensitivity_to	0.93396412
72	MP0005332_abnormal_amino_acid	0.92378814
73	MP0001764_abnormal_homeostasis	0.90105104
74	MP0000689_abnormal_spleen_morphology	0.89798407
75	MP0001501_abnormal_sleep_pattern	0.89336193
76	MP0002722_abnormal_immune_system	0.87453170
77	MP0003186_abnormal_redox_activity	0.86771804
78	MP0002398_abnormal_bone_marrow	0.86234879
79	MP0006036_abnormal_mitochondrial_physio	0.85975947
80	MP0009643_abnormal_urine_homeostasis	0.85568473
81	MP0005636_abnormal_mineral_homeostasis	0.84688818
82	MP0000703_abnormal_thymus_morphology	0.83788071
83	MP0002009_preneoplasia	0.83425782
84	MP0000516_abnormal_urinary_system	0.83135419
85	MP0005367_renal/urinary_system_phenotyp	0.83135419
86	MP0009745_abnormal_behavioral_response	0.83020113
87	MP0001485_abnormal_pinna_reflex	0.82792992
88	MP0006276_abnormal_autonomic_nervous	0.82765488
89	MP0001119_abnormal_female_reproductive	0.80549820
90	MP0002837_dystrophic_cardiac_calcinosis	0.80391617
91	MP0004142_abnormal_muscle_tone	0.80245424
92	MP0005075_abnormal_melanosome_morpholog	0.80061705
93	MP0001929_abnormal_gametogenesis	0.78186774
94	MP0001188_hyperpigmentation	0.77267083
95	MP0000465_gastrointestinal_hemorrhage	0.76861871
96	MP0000631_abnormal_neuroendocrine_gland	0.76692349
97	MP0002429_abnormal_blood_cell	0.76087843
98	MP0008007_abnormal_cellular_replicative	0.75329763
99	MP0003718_maternal_effect	0.74062949
100	MP0000685_abnormal_immune_system	0.72114954

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	3.45623231
2	Acute necrotizing encephalopathy (HP:0006965)	3.45577030
3	Hypoproteinemia (HP:0003075)	3.44672748
4	Mitochondrial inheritance (HP:0001427)	3.30995860
5	Stomatitis (HP:0010280)	3.22554896
6	Progressive macrocephaly (HP:0004481)	3.14124109
7	Pancreatic cysts (HP:0001737)	3.10150445
8	Meckel diverticulum (HP:0002245)	3.04250277
9	Hepatocellular necrosis (HP:0001404)	3.01013783
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.00586003
11	Methylmalonic acidemia (HP:0002912)	2.98730334
12	Abnormality of the ileum (HP:0001549)	2.97276111
13	Acute encephalopathy (HP:0006846)	2.95533956
14	IgG deficiency (HP:0004315)	2.91039150
15	Increased CSF lactate (HP:0002490)	2.88960202
16	Abnormality of the pons (HP:0007361)	2.87643542
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.79914045
18	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.77432663
19	Congenital, generalized hypertrichosis (HP:0004540)	2.73292515
20	Type I transferrin isoform profile (HP:0003642)	2.72946374
21	Pancreatic fibrosis (HP:0100732)	2.72802528
22	True hermaphroditism (HP:0010459)	2.71380050
23	Hepatic necrosis (HP:0002605)	2.65284710
24	Hypoplasia of the pons (HP:0012110)	2.65096136
25	Cerebral edema (HP:0002181)	2.58253695
26	Thyroiditis (HP:0100646)	2.49701808
27	Abolished electroretinogram (ERG) (HP:0000550)	2.48679096
28	Severe combined immunodeficiency (HP:0004430)	2.44351533
29	Congenital stationary night blindness (HP:0007642)	2.43886292
30	Renal cortical cysts (HP:0000803)	2.43667425
31	Abnormality of B cell number (HP:0010975)	2.40481373
32	Clubbing of toes (HP:0100760)	2.39227781
33	Aplasia/hypoplasia of the uterus (HP:0008684)	2.39076683
34	Abnormal protein glycosylation (HP:0012346)	2.38544918
35	Abnormal glycosylation (HP:0012345)	2.38544918
36	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.38544918
37	Abnormal protein N-linked glycosylation (HP:0012347)	2.38544918
38	Nephronophthisis (HP:0000090)	2.37975703
39	Increased hepatocellular lipid droplets (HP:0006565)	2.32590565
40	Attenuation of retinal blood vessels (HP:0007843)	2.32586069
41	Abnormality of the renal cortex (HP:0011035)	2.32341943
42	Abnormality of the preputium (HP:0100587)	2.31357785
43	Optic disc pallor (HP:0000543)	2.30487040
44	Hypoplasia of the uterus (HP:0000013)	2.30074358
45	B lymphocytopenia (HP:0010976)	2.27267107
46	Abnormal rod and cone electroretinograms (HP:0008323)	2.23291404
47	Methylmalonic aciduria (HP:0012120)	2.19575514
48	Elevated erythrocyte sedimentation rate (HP:0003565)	2.19454094
49	Increased serum lactate (HP:0002151)	2.17974918
50	Lipid accumulation in hepatocytes (HP:0006561)	2.14612226
51	T lymphocytopenia (HP:0005403)	2.14340766
52	Reduced antithrombin III activity (HP:0001976)	2.13674688
53	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.13025917
54	Abnormality of alanine metabolism (HP:0010916)	2.13025917
55	Hyperalaninemia (HP:0003348)	2.13025917
56	Pendular nystagmus (HP:0012043)	2.11781707
57	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.11642503
58	Abnormality of the prostate (HP:0008775)	2.11151894
59	Abnormality of T cell number (HP:0011839)	2.05706941
60	Aplastic anemia (HP:0001915)	2.03999415
61	Exertional dyspnea (HP:0002875)	2.03729048
62	Renal Fanconi syndrome (HP:0001994)	2.03583853
63	Abnormality of chromosome stability (HP:0003220)	2.03547443
64	Type 2 muscle fiber atrophy (HP:0003554)	2.03436022
65	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.02457859
66	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.01016038
67	Molar tooth sign on MRI (HP:0002419)	2.00988344
68	Abnormality of midbrain morphology (HP:0002418)	2.00988344
69	Lactic acidosis (HP:0003128)	1.97522357
70	Combined immunodeficiency (HP:0005387)	1.96980312
71	Asplenia (HP:0001746)	1.96976694
72	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.96443438
73	Absent thumb (HP:0009777)	1.96048098
74	Constricted visual fields (HP:0001133)	1.95434638
75	Small intestinal stenosis (HP:0012848)	1.94804807
76	Duodenal stenosis (HP:0100867)	1.94804807
77	Colon cancer (HP:0003003)	1.94777021
78	Abnormality of the renal medulla (HP:0100957)	1.92869288
79	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.92585967
80	Abnormal albumin level (HP:0012116)	1.91075504
81	Hypoalbuminemia (HP:0003073)	1.91075504
82	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.87144233
83	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.87144233
84	Abnormality of the renal collecting system (HP:0004742)	1.86337391
85	Hypomagnesemia (HP:0002917)	1.86155836
86	Pancreatic islet-cell hyperplasia (HP:0004510)	1.85405976
87	Short tibia (HP:0005736)	1.84937448
88	Abnormality of vitamin B metabolism (HP:0004340)	1.84252464
89	Lethargy (HP:0001254)	1.84228871
90	Triphalangeal thumb (HP:0001199)	1.83692909
91	Thyroid-stimulating hormone excess (HP:0002925)	1.83559629
92	Neonatal respiratory distress (HP:0002643)	1.80873036
93	Poor head control (HP:0002421)	1.74973239
94	Abnormality of the duodenum (HP:0002246)	1.74850122
95	Increased intramyocellular lipid droplets (HP:0012240)	1.74554654
96	Increased serum pyruvate (HP:0003542)	1.74214662
97	Exercise intolerance (HP:0003546)	1.73465626
98	Leukodystrophy (HP:0002415)	1.72629277
99	Keratoconus (HP:0000563)	1.72305413
100	Increased corneal curvature (HP:0100692)	1.72305413

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.32535273
2	TLK1	3.45400814
3	ZAK	3.37927577
4	MST4	3.35417660
5	TXK	3.08782236
6	BCKDK	3.03202874
7	NUAK1	2.80534540
8	KDR	2.47267750
9	VRK2	2.46869447
10	TAOK3	2.28577848
11	FRK	2.13198076
12	CDK19	2.11508757
13	ADRBK2	1.99921768
14	VRK1	1.97627467
15	INSRR	1.97184133
16	MKNK1	1.73933431
17	GRK1	1.70642890
18	GRK6	1.67838941
19	LMTK2	1.61811312
20	MAP4K1	1.58579214
21	PINK1	1.51391565
22	SRPK1	1.50558510
23	IKBKE	1.39924825
24	ERBB3	1.37343220
25	FLT3	1.33777262
26	EIF2AK3	1.32181830
27	TESK2	1.27036599
28	PASK	1.23754668
29	WNK3	1.21137715
30	KIT	1.20968971
31	IKBKB	1.17664278
32	BMPR2	1.13144130
33	TIE1	1.10468999
34	BMPR1B	1.07605577
35	ACVR1B	1.02851411
36	EIF2AK2	1.02827186
37	DYRK2	1.02465876
38	TEC	0.98300752
39	PLK3	0.95919482
40	MAP3K14	0.95081595
41	BUB1	0.94831483
42	PKN1	0.90456236
43	ITK	0.86928713
44	PIK3CG	0.85099012
45	GRK7	0.83407109
46	MATK	0.80790003
47	MUSK	0.79450652
48	WNK4	0.78941170
49	RPS6KA5	0.73755348
50	CSNK1G3	0.70915830
51	OXSR1	0.68699681
52	TNK2	0.67566252
53	PRKCQ	0.67390632
54	BTK	0.67079963
55	JAK3	0.66870615
56	PBK	0.66710221
57	LYN	0.65884905
58	NEK1	0.65879019
59	TAF1	0.65616478
60	TBK1	0.64040900
61	LCK	0.63806202
62	TSSK6	0.61179146
63	STK16	0.58698685
64	SYK	0.57992586
65	CSF1R	0.57588054
66	LIMK1	0.56987947
67	RPS6KA4	0.53214223
68	CSNK1G1	0.52813075
69	TGFBR1	0.51799658
70	ADRBK1	0.50801312
71	AURKB	0.50493112
72	CSNK1G2	0.49816173
73	MAPK13	0.48735494
74	FES	0.48682636
75	GRK5	0.46880952
76	CDC7	0.46438938
77	EPHA4	0.46077589
78	TRIM28	0.44299165
79	PIM1	0.43155381
80	PRKCE	0.42805866
81	NME1	0.42665379
82	CSNK1A1L	0.42046746
83	IGF1R	0.41554934
84	DAPK3	0.41015951
85	PLK1	0.40560359
86	CHEK2	0.39241354
87	PRKG2	0.38261777
88	MAP3K12	0.36432079
89	MKNK2	0.36348470
90	PLK4	0.35521840
91	CSNK2A1	0.35448041
92	OBSCN	0.35037937
93	NEK2	0.33491740
94	MAP2K6	0.33154682
95	CSNK1A1	0.32752971
96	ATR	0.32718263
97	AURKA	0.32616109
98	WEE1	0.32597242
99	ERBB2	0.31730667
100	PRKCA	0.31275292

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.35724009
2	Asthma_Homo sapiens_hsa05310	3.11739695
3	Protein export_Homo sapiens_hsa03060	2.99781556
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.97617142
5	Allograft rejection_Homo sapiens_hsa05330	2.74968381
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.73727557
7	Ribosome_Homo sapiens_hsa03010	2.73262364
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.57949553
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.51340084
10	Parkinsons disease_Homo sapiens_hsa05012	2.41567218
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.25483593
12	RNA polymerase_Homo sapiens_hsa03020	2.21012134
13	Sulfur metabolism_Homo sapiens_hsa00920	2.17998530
14	Type I diabetes mellitus_Homo sapiens_hsa04940	2.09709438
15	Homologous recombination_Homo sapiens_hsa03440	1.87490950
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84730324
17	Propanoate metabolism_Homo sapiens_hsa00640	1.76002015
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.71347510
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.58736746
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.54664556
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.54518131
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.52662023
23	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.49201689
24	One carbon pool by folate_Homo sapiens_hsa00670	1.46304123
25	Alzheimers disease_Homo sapiens_hsa05010	1.45786320
26	Huntingtons disease_Homo sapiens_hsa05016	1.44728286
27	RNA degradation_Homo sapiens_hsa03018	1.44715944
28	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.39882668
29	Base excision repair_Homo sapiens_hsa03410	1.33922305
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.32775982
31	Phototransduction_Homo sapiens_hsa04744	1.31742461
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.25964694
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24478861
34	Spliceosome_Homo sapiens_hsa03040	1.23882314
35	Mismatch repair_Homo sapiens_hsa03430	1.21893237
36	Butanoate metabolism_Homo sapiens_hsa00650	1.21461079
37	Basal transcription factors_Homo sapiens_hsa03022	1.20044515
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.18175776
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.17930247
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.15460133
41	Linoleic acid metabolism_Homo sapiens_hsa00591	1.15407591
42	DNA replication_Homo sapiens_hsa03030	1.10065682
43	Peroxisome_Homo sapiens_hsa04146	1.08295070
44	Caffeine metabolism_Homo sapiens_hsa00232	1.04912442
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.04038577
46	Purine metabolism_Homo sapiens_hsa00230	1.03949898
47	Tryptophan metabolism_Homo sapiens_hsa00380	1.03672300
48	Cardiac muscle contraction_Homo sapiens_hsa04260	1.01084243
49	Retinol metabolism_Homo sapiens_hsa00830	1.00473663
50	RNA transport_Homo sapiens_hsa03013	0.99086179
51	Nucleotide excision repair_Homo sapiens_hsa03420	0.98295828
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.97380314
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.91077839
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89891060
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86913470
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.86207466
57	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.83233574
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.81830319
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77234248
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.76224407
61	Viral myocarditis_Homo sapiens_hsa05416	0.76140732
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75600608
63	Selenocompound metabolism_Homo sapiens_hsa00450	0.75430472
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71973032
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.71224544
66	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.70306057
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67628248
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65309460
69	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.64836776
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.63730212
71	Metabolic pathways_Homo sapiens_hsa01100	0.57231989
72	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.57180229
73	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.54395522
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51109094
75	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.49135731
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.47298813
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47073282
78	Pyruvate metabolism_Homo sapiens_hsa00620	0.46358569
79	Fatty acid elongation_Homo sapiens_hsa00062	0.44773846
80	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.43810638
81	Sulfur relay system_Homo sapiens_hsa04122	0.43092769
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.42850075
83	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.41705683
84	Regulation of autophagy_Homo sapiens_hsa04140	0.40456254
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39882527
86	Olfactory transduction_Homo sapiens_hsa04740	0.39122831
87	Alcoholism_Homo sapiens_hsa05034	0.38421686
88	Herpes simplex infection_Homo sapiens_hsa05168	0.36128932
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35753363
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.35615269
91	Glutathione metabolism_Homo sapiens_hsa00480	0.34881939
92	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.34674217
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.32700630
94	Folate biosynthesis_Homo sapiens_hsa00790	0.31913953
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.31704656
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.30682990
97	Fatty acid degradation_Homo sapiens_hsa00071	0.29642351
98	Ether lipid metabolism_Homo sapiens_hsa00565	0.27750191
99	Leishmaniasis_Homo sapiens_hsa05140	0.27398811
100	Taste transduction_Homo sapiens_hsa04742	0.23853065

HNRNPA1P61

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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