HNRNPA1P63

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.72597142
2DNA deamination (GO:0045006)8.39730921
3cytidine catabolic process (GO:0006216)8.00412443
4cytidine deamination (GO:0009972)8.00412443
5cytidine metabolic process (GO:0046087)8.00412443
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.97603563
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.51930826
8sequestering of actin monomers (GO:0042989)5.12984893
9actin nucleation (GO:0045010)4.97110871
10positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.24929585
11positive regulation of natural killer cell mediated immunity (GO:0002717)4.24271677
12regulation of chronic inflammatory response (GO:0002676)4.23919996
13positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.73762984
14regulation of cellular amino acid metabolic process (GO:0006521)3.69700898
15DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.68948862
16regulation of regulatory T cell differentiation (GO:0045589)3.68504331
17negative regulation of T cell apoptotic process (GO:0070233)3.67742997
18positive regulation of prostaglandin secretion (GO:0032308)3.57743957
19cellular response to interleukin-15 (GO:0071350)3.56356935
20signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.56095791
21signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.56095791
22signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.56095791
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.55763839
24signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.55763839
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.54475359
26regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.54434297
27regulation of natural killer cell mediated immunity (GO:0002715)3.54434297
28platelet dense granule organization (GO:0060155)3.50677389
29pyrimidine nucleoside catabolic process (GO:0046135)3.50530972
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45286580
31positive regulation of defense response to virus by host (GO:0002230)3.44000911
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.41550118
33positive regulation of interleukin-8 secretion (GO:2000484)3.40970754
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.40208418
35ATP synthesis coupled proton transport (GO:0015986)3.40208418
36negative regulation of calcium ion transport into cytosol (GO:0010523)3.38720074
37signal transduction involved in DNA damage checkpoint (GO:0072422)3.38011365
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.38011365
39signal transduction involved in cell cycle checkpoint (GO:0072395)3.35405383
40base-excision repair, AP site formation (GO:0006285)3.34925344
41regulation of leukocyte mediated cytotoxicity (GO:0001910)3.34318982
42DNA demethylation (GO:0080111)3.29489095
43negative regulation of viral genome replication (GO:0045071)3.27847842
44proteasome assembly (GO:0043248)3.25538024
45protein-cofactor linkage (GO:0018065)3.25127567
46positive regulation of cell killing (GO:0031343)3.23431865
47negative regulation by host of viral transcription (GO:0043922)3.22735240
48cytolysis (GO:0019835)3.18992941
49negative T cell selection (GO:0043383)3.18938423
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.18817512
51T cell migration (GO:0072678)3.15408311
52water-soluble vitamin biosynthetic process (GO:0042364)3.15324753
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08351108
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06054095
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06054095
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.05260194
57negative regulation of ligase activity (GO:0051352)3.05260194
58regulation of interleukin-8 secretion (GO:2000482)3.02973937
59positive regulation of T cell mediated cytotoxicity (GO:0001916)3.02062409
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.99281831
61regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.99069819
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97653344
63antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.94721554
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.93702932
65regulation of cell killing (GO:0031341)2.92082852
66purine deoxyribonucleotide catabolic process (GO:0009155)2.92025806
67sulfation (GO:0051923)2.90734121
68regulation of interleukin-12 biosynthetic process (GO:0045075)2.90728848
69protein neddylation (GO:0045116)2.89767795
70positive regulation of humoral immune response (GO:0002922)2.86571831
71response to pheromone (GO:0019236)2.86176273
72establishment of protein localization to mitochondrial membrane (GO:0090151)2.82594394
73positive regulation of cell cycle arrest (GO:0071158)2.82382595
74positive regulation of B cell differentiation (GO:0045579)2.81348408
75negative regulation of lymphocyte apoptotic process (GO:0070229)2.80637202
76regulation of prostaglandin secretion (GO:0032306)2.79690669
77lymph node development (GO:0048535)2.77628412
78negative regulation of telomere maintenance (GO:0032205)2.76955369
79electron transport chain (GO:0022900)2.74067487
80respiratory electron transport chain (GO:0022904)2.73220844
81regulation of defense response to virus by host (GO:0050691)2.73059365
82DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.72045096
83regulation of immunoglobulin secretion (GO:0051023)2.71930275
84positive T cell selection (GO:0043368)2.71722411
85regulation of T cell mediated cytotoxicity (GO:0001914)2.71438795
86positive thymic T cell selection (GO:0045059)2.70786216
87positive regulation of calcium-mediated signaling (GO:0050850)2.68469078
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68415428
89response to interferon-beta (GO:0035456)2.68280658
90negative thymic T cell selection (GO:0045060)2.67870512
91regulation of gamma-delta T cell differentiation (GO:0045586)2.66647145
92positive regulation of gamma-delta T cell activation (GO:0046645)2.65554307
93DNA dealkylation (GO:0035510)2.64745839
94protein deneddylation (GO:0000338)2.62386429
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60990461
96pyrimidine-containing compound catabolic process (GO:0072529)2.60872422
97regulation of cellular amine metabolic process (GO:0033238)2.59624690
98regulation of B cell differentiation (GO:0045577)2.59409940
99regulation of isotype switching to IgG isotypes (GO:0048302)2.59102215
100cellular ketone body metabolic process (GO:0046950)2.58086797

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01236360
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.78400485
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.45401861
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.41412822
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.21564345
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16245886
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.11615932
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.91425712
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.90303572
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77292846
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74567000
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.65266330
13VDR_22108803_ChIP-Seq_LS180_Human2.63874547
14ZNF274_21170338_ChIP-Seq_K562_Hela2.60105702
15VDR_23849224_ChIP-Seq_CD4+_Human2.57220493
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.56388721
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.32397855
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.18234103
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.16608515
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.14611285
21IGF1R_20145208_ChIP-Seq_DFB_Human2.13807314
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.10195109
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.02157067
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99564350
25FOXP3_21729870_ChIP-Seq_TREG_Human1.99107554
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98509098
27MYB_26560356_Chip-Seq_TH2_Human1.97625637
28IRF1_19129219_ChIP-ChIP_H3396_Human1.80097801
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.76478586
30ELK1_19687146_ChIP-ChIP_HELA_Human1.72958037
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69922344
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67958431
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.67821063
34PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.66867451
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55299633
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50597691
37GATA3_26560356_Chip-Seq_TH2_Human1.47146207
38MYC_18940864_ChIP-ChIP_HL60_Human1.46466346
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43312332
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41725498
41TP53_22573176_ChIP-Seq_HFKS_Human1.40347125
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40237187
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39375426
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38590076
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37981938
46EWS_26573619_Chip-Seq_HEK293_Human1.37653728
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32725363
48AR_20517297_ChIP-Seq_VCAP_Human1.32396373
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31427097
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27011164
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26651929
52PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25852631
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23648535
54GATA3_27048872_Chip-Seq_THYMUS_Human1.23255047
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23053743
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22665426
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22237874
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.20580116
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20580116
60CIITA_25753668_ChIP-Seq_RAJI_Human1.19459535
61HTT_18923047_ChIP-ChIP_STHdh_Human1.19449058
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19365356
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19236072
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17977865
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15827361
66TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.15352319
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15222184
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14280620
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13901473
70ER_23166858_ChIP-Seq_MCF-7_Human1.13643223
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12087432
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10959538
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10722953
74GABP_19822575_ChIP-Seq_HepG2_Human1.09284322
75RUNX_20019798_ChIP-Seq_JUKART_Human1.06812083
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04639968
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03259807
78TAF15_26573619_Chip-Seq_HEK293_Human1.02800248
79NANOG_20526341_ChIP-Seq_ESCs_Human1.02438884
80NCOR_22424771_ChIP-Seq_293T_Human1.00952699
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97770405
82MYC_19829295_ChIP-Seq_ESCs_Human0.97726466
83PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96917295
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96372150
85MYB_26560356_Chip-Seq_TH1_Human0.95725654
86BCL6_27268052_Chip-Seq_Bcells_Human0.95000298
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94867851
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94472159
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.94469887
90GATA3_21878914_ChIP-Seq_MCF-7_Human0.93646177
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93584134
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.91188682
93SOX2_19829295_ChIP-Seq_ESCs_Human0.90187124
94NANOG_19829295_ChIP-Seq_ESCs_Human0.90187124
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89985714
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.89551777
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89324290
98CBP_20019798_ChIP-Seq_JUKART_Human0.88981973
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88981973
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88535745

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.41638486
2MP0009785_altered_susceptibility_to3.18182560
3MP0002102_abnormal_ear_morphology2.77875086
4MP0009333_abnormal_splenocyte_physiolog2.64618855
5MP0003786_premature_aging2.40604861
6MP0001835_abnormal_antigen_presentation2.25924038
7MP0003763_abnormal_thymus_physiology2.18006899
8MP0002166_altered_tumor_susceptibility2.16642570
9MP0008872_abnormal_physiological_respon2.15598515
10MP0005000_abnormal_immune_tolerance2.13253956
11MP0000685_abnormal_immune_system2.08509325
12MP0002006_tumorigenesis2.03981437
13MP0001800_abnormal_humoral_immune2.01880328
14MP0002148_abnormal_hypersensitivity_rea1.95425445
15MP0002723_abnormal_immune_serum1.93108489
16MP0001501_abnormal_sleep_pattern1.88868633
17MP0001790_abnormal_immune_system1.88136084
18MP0005387_immune_system_phenotype1.88136084
19MP0005645_abnormal_hypothalamus_physiol1.85790790
20MP0005025_abnormal_response_to1.81074136
21MP0002420_abnormal_adaptive_immunity1.80566485
22MP0001819_abnormal_immune_cell1.73243966
23MP0006072_abnormal_retinal_apoptosis1.70632882
24MP0008058_abnormal_DNA_repair1.67113127
25MP0004145_abnormal_muscle_electrophysio1.63358851
26MP0008875_abnormal_xenobiotic_pharmacok1.62624755
27MP0003436_decreased_susceptibility_to1.58358901
28MP0002653_abnormal_ependyma_morphology1.57497818
29MP0008877_abnormal_DNA_methylation1.56395169
30MP0001984_abnormal_olfaction1.50325861
31MP0000716_abnormal_immune_system1.46137292
32MP0000703_abnormal_thymus_morphology1.46111734
33MP0002405_respiratory_system_inflammati1.45448031
34MP0006082_CNS_inflammation1.45401243
35MP0003646_muscle_fatigue1.43944585
36MP0001905_abnormal_dopamine_level1.42802721
37MP0002452_abnormal_antigen_presenting1.42699401
38MP0006292_abnormal_olfactory_placode1.41925878
39MP0002398_abnormal_bone_marrow1.40553830
40MP0003866_abnormal_defecation1.40397862
41MP0001986_abnormal_taste_sensitivity1.38490368
42MP0004147_increased_porphyrin_level1.35799469
43MP0001968_abnormal_touch/_nociception1.35183312
44MP0003195_calcinosis1.33146552
45MP0009764_decreased_sensitivity_to1.33112227
46MP0000689_abnormal_spleen_morphology1.32831400
47MP0002277_abnormal_respiratory_mucosa1.30772187
48MP0005551_abnormal_eye_electrophysiolog1.30418712
49MP0003724_increased_susceptibility_to1.30052839
50MP0002722_abnormal_immune_system1.29146595
51MP0005253_abnormal_eye_physiology1.29082069
52MP0002736_abnormal_nociception_after1.26676481
53MP0003693_abnormal_embryo_hatching1.25331165
54MP0002876_abnormal_thyroid_physiology1.24564661
55MP0002234_abnormal_pharynx_morphology1.23448648
56MP0004885_abnormal_endolymph1.23413816
57MP0001529_abnormal_vocalization1.18186427
58MP0006036_abnormal_mitochondrial_physio1.11614678
59MP0002429_abnormal_blood_cell1.10870486
60MP0008995_early_reproductive_senescence1.10163352
61MP0001845_abnormal_inflammatory_respons1.08132375
62MP0005646_abnormal_pituitary_gland1.07743349
63MP0003137_abnormal_impulse_conducting1.04291338
64MP0008789_abnormal_olfactory_epithelium1.04043431
65MP0001873_stomach_inflammation1.02880608
66MP0010155_abnormal_intestine_physiology1.00486203
67MP0004142_abnormal_muscle_tone0.98069925
68MP0005636_abnormal_mineral_homeostasis0.97656324
69MP0003045_fibrosis0.97603646
70MP0002837_dystrophic_cardiac_calcinosis0.97396887
71MP0002419_abnormal_innate_immunity0.96697129
72MP0001919_abnormal_reproductive_system0.96290912
73MP0002933_joint_inflammation0.95681749
74MP0006276_abnormal_autonomic_nervous0.94612391
75MP0009763_increased_sensitivity_to0.94339610
76MP0005084_abnormal_gallbladder_morpholo0.94168084
77MP0008469_abnormal_protein_level0.92472145
78MP0004742_abnormal_vestibular_system0.91544280
79MP0005075_abnormal_melanosome_morpholog0.91423123
80MP0006035_abnormal_mitochondrial_morpho0.91259142
81MP0005410_abnormal_fertilization0.90262541
82MP0000372_irregular_coat_pigmentation0.89335518
83MP0009745_abnormal_behavioral_response0.86314404
84MP0003448_altered_tumor_morphology0.85984339
85MP0001661_extended_life_span0.83985685
86MP0003011_delayed_dark_adaptation0.79490287
87MP0001533_abnormal_skeleton_physiology0.79451898
88MP0002638_abnormal_pupillary_reflex0.76970913
89MP0002019_abnormal_tumor_incidence0.76793438
90MP0001119_abnormal_female_reproductive0.74691681
91MP0001764_abnormal_homeostasis0.74273282
92MP0005257_abnormal_intraocular_pressure0.74267041
93MP0010094_abnormal_chromosome_stability0.73917288
94MP0003111_abnormal_nucleus_morphology0.72953132
95MP0004957_abnormal_blastocyst_morpholog0.70475727
96MP0001765_abnormal_ion_homeostasis0.70465367
97MP0008007_abnormal_cellular_replicative0.69076117
98MP0005389_reproductive_system_phenotype0.66541982
99MP0002693_abnormal_pancreas_physiology0.66089398
100MP0001293_anophthalmia0.64608239

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.39533801
2Abnormality of T cell number (HP:0011839)4.86346548
3T lymphocytopenia (HP:0005403)4.53446446
4IgG deficiency (HP:0004315)4.41143452
5Increased IgM level (HP:0003496)3.96078742
6Mitochondrial inheritance (HP:0001427)3.81730341
7Severe combined immunodeficiency (HP:0004430)3.79391977
8Hepatocellular necrosis (HP:0001404)3.70146035
9Increased hepatocellular lipid droplets (HP:0006565)3.52700617
103-Methylglutaconic aciduria (HP:0003535)3.48754041
11Hepatic necrosis (HP:0002605)3.36176866
12Stomach cancer (HP:0012126)3.35403216
13Abnormality of eosinophils (HP:0001879)3.31577079
14Autoimmune hemolytic anemia (HP:0001890)3.24162055
15Increased CSF lactate (HP:0002490)3.23772833
16Pancreatic cysts (HP:0001737)3.19311167
17Lipid accumulation in hepatocytes (HP:0006561)3.13251359
18Thyroiditis (HP:0100646)3.11638144
19Abnormality of B cell number (HP:0010975)3.10802890
20Acute necrotizing encephalopathy (HP:0006965)3.07300698
21True hermaphroditism (HP:0010459)3.04289870
22Combined immunodeficiency (HP:0005387)3.02636665
23Abnormality of T cells (HP:0002843)3.02548641
24Congenital stationary night blindness (HP:0007642)3.01607738
25Hypoproteinemia (HP:0003075)3.01429521
26Renal Fanconi syndrome (HP:0001994)2.95675560
27Pancytopenia (HP:0001876)2.91983776
28Renal cortical cysts (HP:0000803)2.91094385
29Generalized aminoaciduria (HP:0002909)2.84184908
30Pancreatic fibrosis (HP:0100732)2.78528268
31Type I transferrin isoform profile (HP:0003642)2.75312102
32Abnormal mitochondria in muscle tissue (HP:0008316)2.67593226
33Increased intramyocellular lipid droplets (HP:0012240)2.64750156
34Abolished electroretinogram (ERG) (HP:0000550)2.63433106
35Elevated erythrocyte sedimentation rate (HP:0003565)2.59206172
36Abnormality of the renal cortex (HP:0011035)2.59009076
37Eosinophilia (HP:0001880)2.58956551
38Autoimmune thrombocytopenia (HP:0001973)2.58141084
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.55245945
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.52638156
41Chronic diarrhea (HP:0002028)2.50988392
42Acute encephalopathy (HP:0006846)2.49387722
43Progressive macrocephaly (HP:0004481)2.47089384
44Lactic acidosis (HP:0003128)2.41445081
45Cerebral edema (HP:0002181)2.40532347
46Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40197039
47Colon cancer (HP:0003003)2.39489055
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37091065
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37091065
50Exertional dyspnea (HP:0002875)2.31981764
51Abnormal albumin level (HP:0012116)2.31130181
52Hypoalbuminemia (HP:0003073)2.31130181
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28246144
54Abnormal protein N-linked glycosylation (HP:0012347)2.28246144
55Abnormal protein glycosylation (HP:0012346)2.28246144
56Abnormal glycosylation (HP:0012345)2.28246144
57Increased serum lactate (HP:0002151)2.27183817
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.21642556
59Molar tooth sign on MRI (HP:0002419)2.21101339
60Abnormality of midbrain morphology (HP:0002418)2.21101339
61Leukocytosis (HP:0001974)2.16940164
62Attenuation of retinal blood vessels (HP:0007843)2.15912381
63Abnormality of the prostate (HP:0008775)2.14879617
64IgM deficiency (HP:0002850)2.14069152
65Oral leukoplakia (HP:0002745)2.10985632
66Increased muscle lipid content (HP:0009058)2.08849628
67Hypoplasia of the pons (HP:0012110)2.05892428
68Aplasia/hypoplasia of the uterus (HP:0008684)2.03817307
69Encephalitis (HP:0002383)2.03619105
70Reduced antithrombin III activity (HP:0001976)2.03329968
71Optic disc pallor (HP:0000543)2.00861888
72Lymphoma (HP:0002665)1.99453757
73Glycosuria (HP:0003076)1.98430756
74Abnormality of urine glucose concentration (HP:0011016)1.98430756
75Respiratory failure (HP:0002878)1.97586425
76Medial flaring of the eyebrow (HP:0010747)1.97220360
77Methylmalonic acidemia (HP:0002912)1.96734728
78Sclerocornea (HP:0000647)1.96630393
79Abnormality of the pons (HP:0007361)1.96556485
80Ketosis (HP:0001946)1.96455579
81Polyuria (HP:0000103)1.96277924
82Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96043821
83Postaxial foot polydactyly (HP:0001830)1.94565078
84Nephronophthisis (HP:0000090)1.92206610
85Methylmalonic aciduria (HP:0012120)1.90825868
86Abnormal rod and cone electroretinograms (HP:0008323)1.90472393
87Hemiplegia (HP:0002301)1.86776951
88Prostate neoplasm (HP:0100787)1.84539822
89Granulocytopenia (HP:0001913)1.84457769
90Dicarboxylic aciduria (HP:0003215)1.83316797
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83316797
92Abnormality of renal resorption (HP:0011038)1.82048659
93Agitation (HP:0000713)1.81460888
94Hypoplasia of the uterus (HP:0000013)1.80797155
95Hypergammaglobulinemia (HP:0010702)1.78934502
96Recurrent bronchitis (HP:0002837)1.78575458
97Recurrent cutaneous fungal infections (HP:0011370)1.76984355
98Chronic mucocutaneous candidiasis (HP:0002728)1.76984355
99Pustule (HP:0200039)1.76005233
100Congenital, generalized hypertrichosis (HP:0004540)1.73479808

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.61748047
2KDR4.29394833
3TESK24.12123722
4MAP4K24.02571078
5BCKDK3.78114077
6ZAK3.66946062
7TLK13.47834671
8VRK22.92478603
9VRK12.64865782
10LIMK12.41512761
11TAOK32.38929290
12PINK12.16310003
13TESK12.08216286
14ADRBK21.94405987
15NUAK11.89728480
16BUB11.83720108
17ITK1.64668967
18MST41.47623467
19CDK191.40248943
20PASK1.39074479
21MAP4K11.33094038
22ERBB31.31937684
23GRK11.25216937
24GRK61.22074547
25SRPK11.15428315
26WNK41.11418244
27NME11.05705060
28DAPK11.00580175
29EIF2AK31.00358525
30FES1.00148904
31BCR0.97237748
32MAP3K120.96895656
33STK160.90763545
34FRK0.87661457
35TRIM280.87449044
36IKBKE0.86459524
37SYK0.84802133
38PRKCQ0.84120856
39GRK70.82653323
40TBK10.82175016
41IKBKB0.79798035
42MAP2K70.76446307
43CSNK1G30.75164195
44LCK0.75010634
45WNK30.69839158
46DAPK20.69232634
47PLK30.68503744
48CAMKK20.68119562
49TIE10.68039185
50TEC0.63621386
51SCYL20.62634030
52MAP3K40.62198092
53RPS6KA50.59580796
54BMPR20.58150273
55LYN0.55390668
56MAPK130.55345092
57BTK0.54495546
58MAPKAPK30.54307946
59DYRK20.53894984
60OXSR10.53854548
61PIK3CA0.52761184
62MYLK0.51253091
63PLK20.50351728
64ZAP700.48654636
65CSNK1G20.48592877
66CSK0.47889257
67CSNK1A1L0.47888714
68NEK10.47420088
69INSRR0.46727574
70CSNK1G10.43929977
71ADRBK10.42381200
72RPS6KA40.42280568
73BMPR1B0.41665735
74TAF10.41476320
75GRK50.40132365
76PLK40.39512491
77AURKA0.39211369
78MATK0.38943188
79CAMKK10.37885899
80IGF1R0.35565313
81EPHA30.35554588
82MAP2K20.35426881
83TSSK60.35221787
84STK390.34419165
85ATR0.34303954
86PHKG20.33477808
87PHKG10.33477808
88KIT0.33189895
89FYN0.30708559
90PLK10.30553261
91TNK20.30217446
92CSNK2A10.28128474
93EIF2AK20.27493286
94PIM10.26878763
95TAOK20.26747332
96PAK10.26582400
97MAP3K50.26563641
98AURKB0.26207495
99PRKCA0.26121019
100OBSCN0.25341860

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.95346456
2Primary immunodeficiency_Homo sapiens_hsa053403.91830927
3Oxidative phosphorylation_Homo sapiens_hsa001902.93604337
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.70834000
5Parkinsons disease_Homo sapiens_hsa050122.45708272
6RNA polymerase_Homo sapiens_hsa030202.44287014
7Protein export_Homo sapiens_hsa030602.26971379
8Graft-versus-host disease_Homo sapiens_hsa053322.24442715
9Autoimmune thyroid disease_Homo sapiens_hsa053202.19523960
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12943464
11Allograft rejection_Homo sapiens_hsa053302.12681837
12Type I diabetes mellitus_Homo sapiens_hsa049402.12494039
13Antigen processing and presentation_Homo sapiens_hsa046122.06515316
14Homologous recombination_Homo sapiens_hsa034401.73511500
15Hematopoietic cell lineage_Homo sapiens_hsa046401.71325751
16Phototransduction_Homo sapiens_hsa047441.69392010
17Sulfur metabolism_Homo sapiens_hsa009201.60362431
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59687126
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55054257
20Huntingtons disease_Homo sapiens_hsa050161.50284599
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49128932
22Alzheimers disease_Homo sapiens_hsa050101.47711679
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43266833
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39292474
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38048666
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.36694784
27Nitrogen metabolism_Homo sapiens_hsa009101.35336000
28Butanoate metabolism_Homo sapiens_hsa006501.34329805
29One carbon pool by folate_Homo sapiens_hsa006701.34126674
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.32931717
31RNA degradation_Homo sapiens_hsa030181.31041654
32T cell receptor signaling pathway_Homo sapiens_hsa046601.29211316
33Base excision repair_Homo sapiens_hsa034101.28991009
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24912397
35Ribosome_Homo sapiens_hsa030101.22802055
36Basal transcription factors_Homo sapiens_hsa030221.17795611
37Pyrimidine metabolism_Homo sapiens_hsa002401.16839151
38Linoleic acid metabolism_Homo sapiens_hsa005911.16567837
39Propanoate metabolism_Homo sapiens_hsa006401.15113505
40Fanconi anemia pathway_Homo sapiens_hsa034601.14342704
41DNA replication_Homo sapiens_hsa030301.10670433
42Rheumatoid arthritis_Homo sapiens_hsa053231.08858008
43Peroxisome_Homo sapiens_hsa041461.06086372
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04419804
45Caffeine metabolism_Homo sapiens_hsa002321.02939772
46Spliceosome_Homo sapiens_hsa030401.02426829
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02350565
48Tryptophan metabolism_Homo sapiens_hsa003800.97957129
49Systemic lupus erythematosus_Homo sapiens_hsa053220.97349924
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94129315
51Purine metabolism_Homo sapiens_hsa002300.91972254
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91663255
53Cardiac muscle contraction_Homo sapiens_hsa042600.91402678
54Mismatch repair_Homo sapiens_hsa034300.90390529
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89410721
56Steroid biosynthesis_Homo sapiens_hsa001000.87067677
57Asthma_Homo sapiens_hsa053100.84489073
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81747791
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81222038
60Nucleotide excision repair_Homo sapiens_hsa034200.78951890
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76505260
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75118223
63Shigellosis_Homo sapiens_hsa051310.74803692
64RNA transport_Homo sapiens_hsa030130.70465311
65Measles_Homo sapiens_hsa051620.69092311
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.66088140
67Collecting duct acid secretion_Homo sapiens_hsa049660.65808442
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65402986
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65136432
70Viral myocarditis_Homo sapiens_hsa054160.61316110
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58020889
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56434321
73Non-homologous end-joining_Homo sapiens_hsa034500.55977551
74Epstein-Barr virus infection_Homo sapiens_hsa051690.52204030
75beta-Alanine metabolism_Homo sapiens_hsa004100.51262420
76Chemical carcinogenesis_Homo sapiens_hsa052040.51053997
77Herpes simplex infection_Homo sapiens_hsa051680.50540258
78Metabolic pathways_Homo sapiens_hsa011000.48737890
79Retinol metabolism_Homo sapiens_hsa008300.45625789
80Olfactory transduction_Homo sapiens_hsa047400.44061325
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42554688
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40950325
83Fatty acid elongation_Homo sapiens_hsa000620.40765565
84Taste transduction_Homo sapiens_hsa047420.40113150
85Regulation of autophagy_Homo sapiens_hsa041400.40085500
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.38802693
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38079386
88Alcoholism_Homo sapiens_hsa050340.36034695
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35568791
90Salmonella infection_Homo sapiens_hsa051320.34492296
91Ether lipid metabolism_Homo sapiens_hsa005650.32530183
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32405484
93Phenylalanine metabolism_Homo sapiens_hsa003600.30336144
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30302381
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28184248
96Nicotine addiction_Homo sapiens_hsa050330.27779216
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27470661
98Fat digestion and absorption_Homo sapiens_hsa049750.26452217
99Arachidonic acid metabolism_Homo sapiens_hsa005900.25195364
100Fatty acid metabolism_Homo sapiens_hsa012120.24490885

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