ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.60172624
2	DNA deamination (GO:0045006)	5.37558886
3	preassembly of GPI anchor in ER membrane (GO:0016254)	4.41848875
4	ATP synthesis coupled proton transport (GO:0015986)	4.15112439
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.15112439
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.04281049
7	GPI anchor metabolic process (GO:0006505)	3.84101616
8	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.80776902
9	GPI anchor biosynthetic process (GO:0006506)	3.73183394
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.70324677
11	cytidine deamination (GO:0009972)	3.63057214
12	cytidine metabolic process (GO:0046087)	3.63057214
13	cytidine catabolic process (GO:0006216)	3.63057214
14	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.56265842
15	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.51605615
16	regulation of regulatory T cell differentiation (GO:0045589)	3.50968105
17	proteasome assembly (GO:0043248)	3.46222879
18	somite development (GO:0061053)	3.44455489
19	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.39151853
20	mannosylation (GO:0097502)	3.38133917
21	negative regulation of telomere maintenance (GO:0032205)	3.36829820
22	behavioral response to ethanol (GO:0048149)	3.30363526
23	protein neddylation (GO:0045116)	3.29048397
24	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.29028636
25	actin nucleation (GO:0045010)	3.24802843
26	chaperone-mediated protein transport (GO:0072321)	3.24326426
27	indolalkylamine catabolic process (GO:0046218)	3.22669420
28	tryptophan catabolic process (GO:0006569)	3.22669420
29	indole-containing compound catabolic process (GO:0042436)	3.22669420
30	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.19620378
31	regulation of isotype switching to IgG isotypes (GO:0048302)	3.15758158
32	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.15036984
33	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.12943367
34	sequestering of actin monomers (GO:0042989)	3.12670801
35	positive regulation of interleukin-17 production (GO:0032740)	3.09604448
36	activated T cell proliferation (GO:0050798)	3.06840226
37	regulation of cellular amino acid metabolic process (GO:0006521)	3.04750456
38	ribosomal small subunit assembly (GO:0000028)	3.03783316
39	kynurenine metabolic process (GO:0070189)	2.96351582
40	indolalkylamine metabolic process (GO:0006586)	2.96171918
41	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.95492818
42	necroptotic process (GO:0070266)	2.93579714
43	ubiquinone metabolic process (GO:0006743)	2.89155875
44	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.88057428
45	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.88057428
46	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.88057428
47	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.87372634
48	protein complex biogenesis (GO:0070271)	2.85813359
49	cellular response to ATP (GO:0071318)	2.85531843
50	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.84320794
51	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.84320794
52	positive regulation of defense response to virus by host (GO:0002230)	2.82700077
53	tryptophan metabolic process (GO:0006568)	2.82645630
54	peptidyl-histidine modification (GO:0018202)	2.82433800
55	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.77560491
56	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.76230749
57	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.74009963
58	glycolipid biosynthetic process (GO:0009247)	2.73164785
59	response to interferon-beta (GO:0035456)	2.72222147
60	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.72005889
61	sulfation (GO:0051923)	2.70603825
62	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.70502186
63	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.70502186
64	behavioral response to nicotine (GO:0035095)	2.68442785
65	L-fucose catabolic process (GO:0042355)	2.66687822
66	fucose catabolic process (GO:0019317)	2.66687822
67	L-fucose metabolic process (GO:0042354)	2.66687822
68	cellular response to interferon-beta (GO:0035458)	2.65221242
69	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.63872432
70	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.63872432
71	platelet dense granule organization (GO:0060155)	2.63579452
72	electron transport chain (GO:0022900)	2.63371395
73	regulation of chronic inflammatory response (GO:0002676)	2.60507048
74	respiratory electron transport chain (GO:0022904)	2.59994123
75	organelle disassembly (GO:1903008)	2.58123901
76	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.56490336
77	regulation of mitotic spindle checkpoint (GO:1903504)	2.56490336
78	programmed necrotic cell death (GO:0097300)	2.56324115
79	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.56200897
80	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.56138997
81	maturation of SSU-rRNA (GO:0030490)	2.56063212
82	isoprenoid biosynthetic process (GO:0008299)	2.54385683
83	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.52859966
84	positive regulation of calcium-mediated signaling (GO:0050850)	2.51486622
85	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.51242242
86	regulation of alpha-beta T cell proliferation (GO:0046640)	2.50949349
87	maturation of 5.8S rRNA (GO:0000460)	2.50607256
88	N-acetylglucosamine metabolic process (GO:0006044)	2.50489143
89	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.50377688
90	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.50339389
91	cornea development in camera-type eye (GO:0061303)	2.50232861
92	purine-containing compound salvage (GO:0043101)	2.49768466
93	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.48631183
94	GTP biosynthetic process (GO:0006183)	2.48392105
95	C-terminal protein lipidation (GO:0006501)	2.48164068
96	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.47779364
97	adult feeding behavior (GO:0008343)	2.46914137
98	regulation of memory T cell differentiation (GO:0043380)	2.44171649
99	resolution of meiotic recombination intermediates (GO:0000712)	2.43051591
100	mitochondrial respiratory chain complex assembly (GO:0033108)	2.41201767

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.74768564
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.18923809
3	VDR_22108803_ChIP-Seq_LS180_Human	3.10654322
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.08453528
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.99221486
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.70166127
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.65815856
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.55418888
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.48658448
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.46946156
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.41599379
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.39148957
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.38063314
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.26663930
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.26460761
16	EWS_26573619_Chip-Seq_HEK293_Human	2.24536725
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.23645740
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.18030276
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.08227438
20	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.08085185
21	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.01255863
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.96410952
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.90504395
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.88085996
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.87650520
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.84751083
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.80373001
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.77406634
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.75728747
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.75676861
31	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.73067719
32	EZH2_22144423_ChIP-Seq_EOC_Human	1.73057123
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.71634110
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66354891
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65775443
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.65775443
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.63468628
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61792654
39	FUS_26573619_Chip-Seq_HEK293_Human	1.59452936
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.59026992
41	P300_19829295_ChIP-Seq_ESCs_Human	1.55510453
42	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.55281761
43	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.55162583
44	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.53095688
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.52768126
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.50990889
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.50146703
48	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.46713308
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46240456
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45760103
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45760103
52	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43732996
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40653619
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.37978461
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.35610436
56	AR_20517297_ChIP-Seq_VCAP_Human	1.32121695
57	GATA3_26560356_Chip-Seq_TH2_Human	1.30525776
58	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29496453
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29382738
60	HTT_18923047_ChIP-ChIP_STHdh_Human	1.27521195
61	MYB_26560356_Chip-Seq_TH2_Human	1.22750042
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21992459
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21849345
64	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18873749
65	BCAT_22108803_ChIP-Seq_LS180_Human	1.16963283
66	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.15131886
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14900229
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14179645
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14179645
70	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.13057064
71	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.11387682
72	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.09993097
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09881691
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09870941
75	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.09510324
76	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08377342
77	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.07781601
78	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.06113869
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01366674
80	NCOR_22424771_ChIP-Seq_293T_Human	1.01031986
81	GATA3_27048872_Chip-Seq_THYMUS_Human	0.99944573
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98971463
83	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.96525355
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95414124
85	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.95086254
86	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94719975
87	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.94130928
88	TCF4_22108803_ChIP-Seq_LS180_Human	0.93508703
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92696899
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92687532
91	RUNX_20019798_ChIP-Seq_JUKART_Human	0.92021396
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.91428877
93	IRF1_19129219_ChIP-ChIP_H3396_Human	0.91332119
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.90405977
95	GATA3_26560356_Chip-Seq_TH1_Human	0.90378370
96	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.90243389
97	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.90173226
98	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.90028498
99	AR_25329375_ChIP-Seq_VCAP_Human	0.89217426
100	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.87624974

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.02199791
2	MP0005671_abnormal_response_to	3.92148948
3	MP0000372_irregular_coat_pigmentation	2.62411055
4	MP0008877_abnormal_DNA_methylation	2.57426910
5	MP0004147_increased_porphyrin_level	2.55636368
6	MP0001835_abnormal_antigen_presentation	2.52330468
7	MP0001905_abnormal_dopamine_level	2.26533313
8	MP0005645_abnormal_hypothalamus_physiol	2.19523128
9	MP0005646_abnormal_pituitary_gland	2.12905250
10	MP0008875_abnormal_xenobiotic_pharmacok	2.12746746
11	MP0003646_muscle_fatigue	2.00991059
12	MP0003195_calcinosis	2.00493633
13	MP0008872_abnormal_physiological_respon	2.00185137
14	MP0009379_abnormal_foot_pigmentation	1.95002676
15	MP0002166_altered_tumor_susceptibility	1.94522501
16	MP0002277_abnormal_respiratory_mucosa	1.93924306
17	MP0006072_abnormal_retinal_apoptosis	1.91694042
18	MP0003806_abnormal_nucleotide_metabolis	1.77920193
19	MP0003283_abnormal_digestive_organ	1.77442359
20	MP0002638_abnormal_pupillary_reflex	1.76564900
21	MP0003763_abnormal_thymus_physiology	1.76250050
22	MP0002009_preneoplasia	1.70887604
23	MP0001968_abnormal_touch/_nociception	1.66978736
24	MP0002138_abnormal_hepatobiliary_system	1.62568478
25	MP0003880_abnormal_central_pattern	1.61952007
26	MP0009785_altered_susceptibility_to	1.59536256
27	MP0005253_abnormal_eye_physiology	1.58861331
28	MP0002736_abnormal_nociception_after	1.58618904
29	MP0001873_stomach_inflammation	1.58446902
30	MP0003718_maternal_effect	1.57298314
31	MP0002006_tumorigenesis	1.55842289
32	MP0005410_abnormal_fertilization	1.50864971
33	MP0002148_abnormal_hypersensitivity_rea	1.49354139
34	MP0004145_abnormal_muscle_electrophysio	1.48852296
35	MP0003011_delayed_dark_adaptation	1.43786263
36	MP0005551_abnormal_eye_electrophysiolog	1.43062941
37	MP0002938_white_spotting	1.37720440
38	MP0001188_hyperpigmentation	1.37554338
39	MP0005000_abnormal_immune_tolerance	1.35482547
40	MP0003724_increased_susceptibility_to	1.34033035
41	MP0008995_early_reproductive_senescence	1.29380192
42	MP0001800_abnormal_humoral_immune	1.28431723
43	MP0002876_abnormal_thyroid_physiology	1.28000206
44	MP0002234_abnormal_pharynx_morphology	1.26776012
45	MP0001986_abnormal_taste_sensitivity	1.24962340
46	MP0009764_decreased_sensitivity_to	1.23526935
47	MP0001764_abnormal_homeostasis	1.23386233
48	MP0002723_abnormal_immune_serum	1.21387428
49	MP0009697_abnormal_copulation	1.21352139
50	MP0003787_abnormal_imprinting	1.20144078
51	MP0005084_abnormal_gallbladder_morpholo	1.19721719
52	MP0004043_abnormal_pH_regulation	1.17943388
53	MP0002735_abnormal_chemical_nociception	1.16776879
54	MP0004142_abnormal_muscle_tone	1.16016643
55	MP0009333_abnormal_splenocyte_physiolog	1.15911464
56	MP0000465_gastrointestinal_hemorrhage	1.15809015
57	MP0003786_premature_aging	1.13937549
58	MP0004885_abnormal_endolymph	1.13098853
59	MP0001819_abnormal_immune_cell	1.12810682
60	MP0005075_abnormal_melanosome_morpholog	1.11473343
61	MP0006276_abnormal_autonomic_nervous	1.11410383
62	MP0002420_abnormal_adaptive_immunity	1.08611219
63	MP0002452_abnormal_antigen_presenting	1.06423466
64	MP0008058_abnormal_DNA_repair	1.06308145
65	MP0000647_abnormal_sebaceous_gland	1.04114508
66	MP0002751_abnormal_autonomic_nervous	1.03158839
67	MP0005423_abnormal_somatic_nervous	1.02878371
68	MP0003693_abnormal_embryo_hatching	0.99814703
69	MP0006292_abnormal_olfactory_placode	0.99081583
70	MP0002272_abnormal_nervous_system	0.97821216
71	MP0001529_abnormal_vocalization	0.96313193
72	MP0003638_abnormal_response/metabolism_	0.95331050
73	MP0000049_abnormal_middle_ear	0.94574350
74	MP0002837_dystrophic_cardiac_calcinosis	0.92824114
75	MP0000631_abnormal_neuroendocrine_gland	0.92150153
76	MP0003950_abnormal_plasma_membrane	0.92073442
77	MP0005167_abnormal_blood-brain_barrier	0.91977914
78	MP0003119_abnormal_digestive_system	0.91616896
79	MP0005387_immune_system_phenotype	0.91085800
80	MP0001790_abnormal_immune_system	0.91085800
81	MP0006035_abnormal_mitochondrial_morpho	0.89370197
82	MP0002139_abnormal_hepatobiliary_system	0.88897511
83	MP0001845_abnormal_inflammatory_respons	0.88549407
84	MP0005025_abnormal_response_to	0.87987771
85	MP0001501_abnormal_sleep_pattern	0.87155505
86	MP0009745_abnormal_behavioral_response	0.85067497
87	MP0002095_abnormal_skin_pigmentation	0.83710043
88	MP0003191_abnormal_cellular_cholesterol	0.82900134
89	MP0000639_abnormal_adrenal_gland	0.82721336
90	MP0002184_abnormal_innervation	0.82077768
91	MP0010155_abnormal_intestine_physiology	0.81243716
92	MP0003252_abnormal_bile_duct	0.80975552
93	MP0003866_abnormal_defecation	0.80537968
94	MP0006036_abnormal_mitochondrial_physio	0.77080396
95	MP0000716_abnormal_immune_system	0.77061390
96	MP0000689_abnormal_spleen_morphology	0.71890491
97	MP0001486_abnormal_startle_reflex	0.70853327
98	MP0000383_abnormal_hair_follicle	0.70081008
99	MP0000230_abnormal_systemic_arterial	0.69556296
100	MP0005636_abnormal_mineral_homeostasis	0.69310757

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.67398781
2	Hypoproteinemia (HP:0003075)	3.50194213
3	Acute necrotizing encephalopathy (HP:0006965)	3.49761278
4	Pancreatic cysts (HP:0001737)	3.33681574
5	Methylmalonic acidemia (HP:0002912)	3.31965060
6	Dyschromatopsia (HP:0007641)	3.07050082
7	Abnormality of the pons (HP:0007361)	3.06666069
8	Abnormality of the prostate (HP:0008775)	3.02901785
9	Constricted visual fields (HP:0001133)	2.99030225
10	Mitochondrial inheritance (HP:0001427)	2.98442725
11	Congenital stationary night blindness (HP:0007642)	2.98360989
12	3-Methylglutaconic aciduria (HP:0003535)	2.97304653
13	Pancreatic fibrosis (HP:0100732)	2.95040975
14	Abnormal mitochondria in muscle tissue (HP:0008316)	2.94343781
15	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.88368755
16	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.88368755
17	Progressive macrocephaly (HP:0004481)	2.87536542
18	Increased CSF lactate (HP:0002490)	2.86717131
19	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.85766172
20	IgG deficiency (HP:0004315)	2.82101656
21	Abolished electroretinogram (ERG) (HP:0000550)	2.80463962
22	Increased hepatocellular lipid droplets (HP:0006565)	2.79829907
23	Stomatitis (HP:0010280)	2.79378165
24	Acute encephalopathy (HP:0006846)	2.78804355
25	Attenuation of retinal blood vessels (HP:0007843)	2.72299579
26	Prostate neoplasm (HP:0100787)	2.70309002
27	Aplastic anemia (HP:0001915)	2.68494247
28	Hypoplasia of the pons (HP:0012110)	2.68038381
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.63585549
30	Molar tooth sign on MRI (HP:0002419)	2.56920678
31	Abnormality of midbrain morphology (HP:0002418)	2.56920678
32	Pendular nystagmus (HP:0012043)	2.52195946
33	Severe combined immunodeficiency (HP:0004430)	2.48364810
34	Reduced antithrombin III activity (HP:0001976)	2.46159761
35	Methylmalonic aciduria (HP:0012120)	2.45898599
36	True hermaphroditism (HP:0010459)	2.42717878
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.42179550
38	Abnormality of alanine metabolism (HP:0010916)	2.42179550
39	Hyperalaninemia (HP:0003348)	2.42179550
40	Decreased central vision (HP:0007663)	2.38345427
41	Hepatocellular necrosis (HP:0001404)	2.37995054
42	Type II lissencephaly (HP:0007260)	2.34677926
43	Lipid accumulation in hepatocytes (HP:0006561)	2.30909475
44	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.29732221
45	T lymphocytopenia (HP:0005403)	2.28414995
46	Nephronophthisis (HP:0000090)	2.28336644
47	Elevated erythrocyte sedimentation rate (HP:0003565)	2.27392105
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.26626303
49	Absent/shortened dynein arms (HP:0200106)	2.26626303
50	Renal Fanconi syndrome (HP:0001994)	2.24786486
51	Optic disc pallor (HP:0000543)	2.24634229
52	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.22040571
53	Chorioretinal atrophy (HP:0000533)	2.21240278
54	Cerebral edema (HP:0002181)	2.20816989
55	Abnormality of T cell number (HP:0011839)	2.20658005
56	Abnormality of the renal cortex (HP:0011035)	2.20190016
57	Type 2 muscle fiber atrophy (HP:0003554)	2.19803253
58	Stomach cancer (HP:0012126)	2.19563306
59	Increased serum lactate (HP:0002151)	2.16190808
60	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.16054796
61	Increased corneal curvature (HP:0100692)	2.14109616
62	Keratoconus (HP:0000563)	2.14109616
63	Oral leukoplakia (HP:0002745)	2.13127198
64	Thyroiditis (HP:0100646)	2.08380053
65	Asplenia (HP:0001746)	2.07712915
66	Exertional dyspnea (HP:0002875)	2.06315491
67	Cerebral palsy (HP:0100021)	2.05203875
68	Leukodystrophy (HP:0002415)	2.04063484
69	Abnormality of vitamin B metabolism (HP:0004340)	2.03959870
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.02760276
71	Aplasia/hypoplasia of the uterus (HP:0008684)	2.00575781
72	Renal cortical cysts (HP:0000803)	1.99833448
73	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.98655251
74	Hypothermia (HP:0002045)	1.97616130
75	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.96887773
76	Testicular atrophy (HP:0000029)	1.94694266
77	Abnormality of T cells (HP:0002843)	1.94218116
78	Autoimmune hemolytic anemia (HP:0001890)	1.93541054
79	Abnormality of the renal medulla (HP:0100957)	1.93324436
80	Central scotoma (HP:0000603)	1.92772745
81	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.91628236
82	Hypoplasia of the uterus (HP:0000013)	1.91426815
83	Hepatic necrosis (HP:0002605)	1.91206267
84	Lethargy (HP:0001254)	1.90614104
85	Lactic acidosis (HP:0003128)	1.88988739
86	Aplasia of the musculature (HP:0100854)	1.85944647
87	Abnormality of serum amino acid levels (HP:0003112)	1.85412851
88	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.85044244
89	Progressive inability to walk (HP:0002505)	1.84732672
90	Large for gestational age (HP:0001520)	1.83095612
91	Pancytopenia (HP:0001876)	1.81831495
92	Colon cancer (HP:0003003)	1.79520460
93	Combined immunodeficiency (HP:0005387)	1.78177866
94	Cystic liver disease (HP:0006706)	1.77724096
95	Neonatal respiratory distress (HP:0002643)	1.77237549
96	Abnormality of placental membranes (HP:0011409)	1.76983207
97	Amniotic constriction ring (HP:0009775)	1.76983207
98	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.74476336
99	Abnormality of methionine metabolism (HP:0010901)	1.74132967
100	Scotoma (HP:0000575)	1.72915169

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.62276521
2	TLK1	3.50317892
3	TAOK3	3.21263063
4	TXK	3.03659266
5	MUSK	2.99740757
6	ADRBK2	2.81971067
7	TESK2	2.74328489
8	MAP4K2	2.45059194
9	GRK1	2.37151493
10	ERBB3	2.33366362
11	STK16	2.27539132
12	VRK2	2.07785800
13	VRK1	2.07753898
14	TIE1	1.82280897
15	KDR	1.72275634
16	NUAK1	1.70003931
17	PASK	1.61371052
18	BCKDK	1.61020803
19	MAP3K4	1.58824132
20	TEC	1.58178347
21	IKBKE	1.54987306
22	TNIK	1.52449146
23	MKNK1	1.51212296
24	KIT	1.46457840
25	TRIM28	1.45322777
26	TNK2	1.43189737
27	ITK	1.40025542
28	FRK	1.38235368
29	WNK4	1.37095604
30	TSSK6	1.30760214
31	MAP2K7	1.26308694
32	WNK3	1.21619196
33	MAP3K12	1.21495613
34	PINK1	1.21243413
35	BUB1	1.19643847
36	FES	1.15591159
37	IKBKB	1.12270045
38	SYK	1.03586898
39	NEK1	1.01046803
40	SRPK1	0.99613442
41	TAF1	0.99328553
42	CDC7	0.97306651
43	MST4	0.97049198
44	CSNK1G3	0.96567054
45	MAPK13	0.88107325
46	INSRR	0.87866113
47	MYLK	0.85599339
48	MAP3K14	0.81445284
49	CSNK1G1	0.80395619
50	CSNK1A1L	0.80271931
51	RPS6KA5	0.78897457
52	ATR	0.78753452
53	BTK	0.77148888
54	OXSR1	0.71522165
55	MAP4K1	0.71297772
56	PLK3	0.69890526
57	CASK	0.68490490
58	CSNK1G2	0.68250961
59	PRKCQ	0.66786130
60	CSF1R	0.66644169
61	STK39	0.66012812
62	EIF2AK3	0.65148433
63	NME1	0.64515805
64	JAK3	0.62278921
65	TBK1	0.61413611
66	LYN	0.61067909
67	OBSCN	0.60153598
68	LCK	0.58870254
69	ERBB4	0.58190717
70	MAPKAPK5	0.56268238
71	BMPR1B	0.56179523
72	PLK4	0.54517629
73	ZAP70	0.54486849
74	CSNK2A1	0.54186740
75	SIK3	0.52831248
76	PIM1	0.51665410
77	DYRK2	0.50828578
78	GRK7	0.50157723
79	RPS6KA4	0.48691285
80	IGF1R	0.47797630
81	PIK3CG	0.46875381
82	ADRBK1	0.45665634
83	PRKCE	0.45665553
84	DAPK2	0.45306546
85	BMPR2	0.44602983
86	WEE1	0.42235294
87	PLK2	0.42041064
88	CSNK1A1	0.41294767
89	SCYL2	0.40496513
90	NEK9	0.40056541
91	BCR	0.39276412
92	MAPK15	0.36978623
93	MAP2K6	0.36732447
94	FLT3	0.36339879
95	PRKG2	0.35003389
96	MKNK2	0.34199528
97	GRK6	0.33894335
98	PRKCA	0.33406608
99	CSNK2A2	0.33220102
100	PRKACA	0.32968618

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.57007752
2	Asthma_Homo sapiens_hsa05310	3.52997794
3	Allograft rejection_Homo sapiens_hsa05330	3.10333408
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.06475593
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.01670580
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.82194453
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.81771881
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.67792115
9	Protein export_Homo sapiens_hsa03060	2.39945918
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.36779870
11	Parkinsons disease_Homo sapiens_hsa05012	2.20493790
12	Primary immunodeficiency_Homo sapiens_hsa05340	2.19885033
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.94438716
14	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.92350443
15	Ribosome_Homo sapiens_hsa03010	1.87018698
16	Antigen processing and presentation_Homo sapiens_hsa04612	1.82268501
17	Basal transcription factors_Homo sapiens_hsa03022	1.81687997
18	RNA polymerase_Homo sapiens_hsa03020	1.81347297
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.55272435
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.53849870
21	Phototransduction_Homo sapiens_hsa04744	1.52968934
22	Homologous recombination_Homo sapiens_hsa03440	1.48106414
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.42437167
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.38801844
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.37091602
26	RNA degradation_Homo sapiens_hsa03018	1.35592621
27	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.25835941
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.23059131
29	Alzheimers disease_Homo sapiens_hsa05010	1.21646387
30	Huntingtons disease_Homo sapiens_hsa05016	1.18894377
31	Peroxisome_Homo sapiens_hsa04146	1.13858935
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11579429
33	Mismatch repair_Homo sapiens_hsa03430	1.10204695
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.08384853
35	One carbon pool by folate_Homo sapiens_hsa00670	1.07628908
36	Viral myocarditis_Homo sapiens_hsa05416	1.06775723
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.98771898
38	Propanoate metabolism_Homo sapiens_hsa00640	0.98549841
39	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.97021153
40	Spliceosome_Homo sapiens_hsa03040	0.96939629
41	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.96467995
42	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.96412531
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95382486
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93681133
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91298689
46	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.89015466
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87905052
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.87540515
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.86948514
50	Retinol metabolism_Homo sapiens_hsa00830	0.86709248
51	Olfactory transduction_Homo sapiens_hsa04740	0.85516681
52	RNA transport_Homo sapiens_hsa03013	0.85227365
53	Caffeine metabolism_Homo sapiens_hsa00232	0.84890755
54	Taste transduction_Homo sapiens_hsa04742	0.83925015
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.83391203
56	Butanoate metabolism_Homo sapiens_hsa00650	0.82356368
57	DNA replication_Homo sapiens_hsa03030	0.81856821
58	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.81025336
59	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.80470375
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78981103
61	Purine metabolism_Homo sapiens_hsa00230	0.77649929
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.77008109
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.76696016
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76528115
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73842627
66	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.71680835
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.69915173
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.69292773
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68304702
70	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.68191504
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67190612
72	Steroid biosynthesis_Homo sapiens_hsa00100	0.66914725
73	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.66042074
74	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.65867503
75	Herpes simplex infection_Homo sapiens_hsa05168	0.57890557
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57627809
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.54409597
78	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54402183
79	Base excision repair_Homo sapiens_hsa03410	0.53268466
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.52584030
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51637104
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.48398124
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48126744
84	Metabolic pathways_Homo sapiens_hsa01100	0.46911144
85	Pyruvate metabolism_Homo sapiens_hsa00620	0.45233105
86	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.43872310
87	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.42749894
88	Fatty acid degradation_Homo sapiens_hsa00071	0.40737219
89	Nicotine addiction_Homo sapiens_hsa05033	0.40506544
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.39133389
91	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.37310230
92	Histidine metabolism_Homo sapiens_hsa00340	0.37119538
93	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.36978195
94	Salivary secretion_Homo sapiens_hsa04970	0.34411225
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33904170
96	Measles_Homo sapiens_hsa05162	0.33408681
97	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.33398738
98	Leishmaniasis_Homo sapiens_hsa05140	0.32714372
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30075537
100	Regulation of autophagy_Homo sapiens_hsa04140	0.30043345

HNRNPA1P64

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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