ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	labyrinthine layer development (GO:0060711)	5.31094946
2	proteasome assembly (GO:0043248)	5.24790389
3	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	5.03786208
4	DNA double-strand break processing (GO:0000729)	4.88130987
5	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.86488910
6	4-hydroxyproline metabolic process (GO:0019471)	4.30788714
7	peptidyl-proline hydroxylation (GO:0019511)	4.28582072
8	IMP biosynthetic process (GO:0006188)	4.20434558
9	response to nitric oxide (GO:0071731)	4.18755132
10	piRNA metabolic process (GO:0034587)	4.05573061
11	rRNA modification (GO:0000154)	3.99890710
12	synapsis (GO:0007129)	3.99330983
13	rRNA methylation (GO:0031167)	3.99222451
14	DNA catabolic process, exonucleolytic (GO:0000738)	3.93190425
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.92949049
16	IMP metabolic process (GO:0046040)	3.79130327
17	ribosomal small subunit assembly (GO:0000028)	3.66962765
18	protein hydroxylation (GO:0018126)	3.64038350
19	chromatin remodeling at centromere (GO:0031055)	3.61901482
20	cullin deneddylation (GO:0010388)	3.59775856
21	toxin transport (GO:1901998)	3.59141435
22	ribosome assembly (GO:0042255)	3.56078779
23	respiratory chain complex IV assembly (GO:0008535)	3.55840182
24	CENP-A containing nucleosome assembly (GO:0034080)	3.54608056
25	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.54094564
26	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.44901621
27	peptidyl-histidine modification (GO:0018202)	3.38497802
28	spliceosomal snRNP assembly (GO:0000387)	3.34191578
29	protein deneddylation (GO:0000338)	3.30081546
30	DNA replication-dependent nucleosome organization (GO:0034723)	3.28451860
31	DNA replication-dependent nucleosome assembly (GO:0006335)	3.28451860
32	gene silencing by RNA (GO:0031047)	3.28206465
33	positive regulation of digestive system process (GO:0060456)	3.26493141
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.25775566
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.25775566
36	NADH dehydrogenase complex assembly (GO:0010257)	3.25775566
37	carnitine transmembrane transport (GO:1902603)	3.22533609
38	amino acid salvage (GO:0043102)	3.21617619
39	L-methionine salvage (GO:0071267)	3.21617619
40	L-methionine biosynthetic process (GO:0071265)	3.21617619
41	double-strand break repair via homologous recombination (GO:0000724)	3.18010353
42	recombinational repair (GO:0000725)	3.17376712
43	DNA damage response, detection of DNA damage (GO:0042769)	3.16680769
44	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.12898696
45	mitotic metaphase plate congression (GO:0007080)	3.12344434
46	rRNA catabolic process (GO:0016075)	3.09911058
47	nucleobase biosynthetic process (GO:0046112)	3.09727566
48	mitochondrial respiratory chain complex assembly (GO:0033108)	3.08574526
49	telomere maintenance via semi-conservative replication (GO:0032201)	3.07718267
50	pseudouridine synthesis (GO:0001522)	3.07656578
51	resolution of meiotic recombination intermediates (GO:0000712)	3.06386670
52	protein complex biogenesis (GO:0070271)	3.06022999
53	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.05957944
54	DNA ligation (GO:0006266)	3.04004592
55	water-soluble vitamin biosynthetic process (GO:0042364)	2.98617573
56	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)	2.98325193
57	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.98073229
58	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.98073229
59	cytochrome complex assembly (GO:0017004)	2.97531384
60	purine nucleobase biosynthetic process (GO:0009113)	2.97325072
61	DNA replication-independent nucleosome organization (GO:0034724)	2.96288321
62	DNA replication-independent nucleosome assembly (GO:0006336)	2.96288321
63	rRNA transcription (GO:0009303)	2.92907312
64	carnitine transport (GO:0015879)	2.91498009
65	amino-acid betaine transport (GO:0015838)	2.91498009
66	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.90608031
67	histone exchange (GO:0043486)	2.90215611
68	mRNA cleavage (GO:0006379)	2.85267343
69	transcription from mitochondrial promoter (GO:0006390)	2.84303116
70	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.82193138
71	mannosylation (GO:0097502)	2.81847550
72	kinetochore assembly (GO:0051382)	2.81668566
73	response to nitrosative stress (GO:0051409)	2.80709569
74	DNA deamination (GO:0045006)	2.78018862
75	GTP biosynthetic process (GO:0006183)	2.73599972
76	chromosome organization involved in meiosis (GO:0070192)	2.69679960
77	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.68412441
78	negative regulation of ligase activity (GO:0051352)	2.68412441
79	regulation of skeletal muscle contraction (GO:0014819)	2.64770578
80	positive regulation of organelle assembly (GO:1902117)	2.64667927
81	AMP metabolic process (GO:0046033)	2.63433883
82	termination of RNA polymerase I transcription (GO:0006363)	2.62798595
83	heart trabecula formation (GO:0060347)	2.61683342
84	DNA strand elongation involved in DNA replication (GO:0006271)	2.61619624
85	DNA replication initiation (GO:0006270)	2.59844704
86	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.59619152
87	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.58616728
88	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.58616728
89	drug transmembrane transport (GO:0006855)	2.58481348
90	metaphase plate congression (GO:0051310)	2.57687442
91	UTP biosynthetic process (GO:0006228)	2.57633560
92	coenzyme catabolic process (GO:0009109)	2.57554651
93	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.57170756
94	telomere maintenance via telomere lengthening (GO:0010833)	2.56714390
95	UTP metabolic process (GO:0046051)	2.56455591
96	male meiosis (GO:0007140)	2.54063838
97	ribosomal large subunit biogenesis (GO:0042273)	2.53448259
98	telomere maintenance via recombination (GO:0000722)	2.52012302
99	platelet dense granule organization (GO:0060155)	2.51928471
100	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.51527447

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.23974623
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.23557109
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.77218807
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.63749410
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.10481960
6	VDR_22108803_ChIP-Seq_LS180_Human	3.07704915
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00603595
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.91798496
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.74638277
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.60307711
11	EWS_26573619_Chip-Seq_HEK293_Human	2.41735742
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.41523130
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.40286792
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.37799358
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.37154489
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.33108770
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.17796865
18	FUS_26573619_Chip-Seq_HEK293_Human	2.14959646
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.12617339
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.11059393
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.02846842
22	FOXP3_21729870_ChIP-Seq_TREG_Human	2.00686134
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.96042004
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.83183927
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.80475136
26	GATA1_22025678_ChIP-Seq_K562_Human	1.78206245
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.73384099
28	E2F7_22180533_ChIP-Seq_HELA_Human	1.72113301
29	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.67352050
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66080790
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.65845072
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.63447867
33	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.62743245
34	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.57078524
35	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.56051371
36	P300_19829295_ChIP-Seq_ESCs_Human	1.55279081
37	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54001015
38	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.52626143
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.51121614
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50757156
41	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50610934
42	DCP1A_22483619_ChIP-Seq_HELA_Human	1.49783778
43	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.42899347
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.38788130
45	TTF2_22483619_ChIP-Seq_HELA_Human	1.37207970
46	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.36480787
47	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.35991361
48	GABP_19822575_ChIP-Seq_HepG2_Human	1.33460021
49	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.31603487
50	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.30940369
51	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.27978887
52	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.27890096
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27013736
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27013736
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.26640179
56	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.25401428
57	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.24552214
58	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.24368832
59	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.20887473
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16918110
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16918110
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14965369
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.14965369
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14288708
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.14133795
66	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.13088731
67	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.13022784
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.11751362
69	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.11116256
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10911182
71	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.09004720
72	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.07782440
73	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06566418
74	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.06458702
75	TP53_22573176_ChIP-Seq_HFKS_Human	1.06094011
76	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.05496273
77	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05122763
78	AR_20517297_ChIP-Seq_VCAP_Human	1.04395330
79	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.03747006
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02805462
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01322870
82	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00067085
83	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.98101402
84	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.97294117
85	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.97178150
86	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97160804
87	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.96886203
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96261598
89	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.95657221
90	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.95154390
91	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.94693157
92	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.94594337
93	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.94037462
94	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93610391
95	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.93493033
96	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.92455491
97	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.91405930
98	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.88432817
99	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.87413698
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.86843634

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	3.78044247
2	MP0004145_abnormal_muscle_electrophysio	3.60972657
3	MP0003646_muscle_fatigue	3.50709997
4	MP0008058_abnormal_DNA_repair	3.46619300
5	MP0004957_abnormal_blastocyst_morpholog	2.66735657
6	MP0005083_abnormal_biliary_tract	2.66438303
7	MP0003718_maternal_effect	2.64640686
8	MP0008877_abnormal_DNA_methylation	2.63999375
9	MP0004484_altered_response_of	2.46912328
10	MP0005084_abnormal_gallbladder_morpholo	2.39426142
11	MP0003786_premature_aging	2.31826163
12	MP0004147_increased_porphyrin_level	2.27747222
13	MP0006072_abnormal_retinal_apoptosis	2.11028439
14	MP0009697_abnormal_copulation	2.10698888
15	MP0010094_abnormal_chromosome_stability	2.05985876
16	MP0002102_abnormal_ear_morphology	2.05261084
17	MP0008995_early_reproductive_senescence	2.03212014
18	MP0003693_abnormal_embryo_hatching	1.94920337
19	MP0005330_cardiomyopathy	1.91644966
20	MP0000749_muscle_degeneration	1.83156607
21	MP0000383_abnormal_hair_follicle	1.80470146
22	MP0004215_abnormal_myocardial_fiber	1.76211477
23	MP0001873_stomach_inflammation	1.69176378
24	MP0000049_abnormal_middle_ear	1.67985726
25	MP0001293_anophthalmia	1.66334936
26	MP0006292_abnormal_olfactory_placode	1.64917205
27	MP0003567_abnormal_fetal_cardiomyocyte	1.64871271
28	MP0001529_abnormal_vocalization	1.58963547
29	MP0008932_abnormal_embryonic_tissue	1.53442683
30	MP0010368_abnormal_lymphatic_system	1.50847895
31	MP0006035_abnormal_mitochondrial_morpho	1.50170572
32	MP0005253_abnormal_eye_physiology	1.48911919
33	MP0001661_extended_life_span	1.44647026
34	MP0003111_abnormal_nucleus_morphology	1.44626591
35	MP0006036_abnormal_mitochondrial_physio	1.44369098
36	MP0005167_abnormal_blood-brain_barrier	1.43778888
37	MP0003077_abnormal_cell_cycle	1.43153816
38	MP0004084_abnormal_cardiac_muscle	1.42437235
39	MP0003937_abnormal_limbs/digits/tail_de	1.42156289
40	MP0008875_abnormal_xenobiotic_pharmacok	1.41157005
41	MP0001188_hyperpigmentation	1.37522595
42	MP0004036_abnormal_muscle_relaxation	1.35544972
43	MP0002160_abnormal_reproductive_system	1.33121289
44	MP0002138_abnormal_hepatobiliary_system	1.29266316
45	MP0005645_abnormal_hypothalamus_physiol	1.27917837
46	MP0006054_spinal_hemorrhage	1.26156393
47	MP0002837_dystrophic_cardiac_calcinosis	1.21986669
48	MP0010678_abnormal_skin_adnexa	1.19889240
49	MP0000372_irregular_coat_pigmentation	1.17146663
50	MP0005377_hearing/vestibular/ear_phenot	1.16084283
51	MP0003878_abnormal_ear_physiology	1.16084283
52	MP0003890_abnormal_embryonic-extraembry	1.15369723
53	MP0001929_abnormal_gametogenesis	1.15040437
54	MP0003941_abnormal_skin_development	1.12372168
55	MP0001348_abnormal_lacrimal_gland	1.12133773
56	MP0008872_abnormal_physiological_respon	1.11594486
57	MP0008789_abnormal_olfactory_epithelium	1.09314205
58	MP0002210_abnormal_sex_determination	1.06447014
59	MP0001145_abnormal_male_reproductive	1.03506515
60	MP0002234_abnormal_pharynx_morphology	1.00039279
61	MP0000631_abnormal_neuroendocrine_gland	0.99954062
62	MP0002938_white_spotting	0.99912094
63	MP0005389_reproductive_system_phenotype	0.99795946
64	MP0001879_abnormal_lymphatic_vessel	0.96679909
65	MP0003121_genomic_imprinting	0.96372580
66	MP0003186_abnormal_redox_activity	0.95063010
67	MP0001764_abnormal_homeostasis	0.94803424
68	MP0005551_abnormal_eye_electrophysiolog	0.93098565
69	MP0005085_abnormal_gallbladder_physiolo	0.93030618
70	MP0003252_abnormal_bile_duct	0.92856839
71	MP0002282_abnormal_trachea_morphology	0.89436882
72	MP0002127_abnormal_cardiovascular_syste	0.89185572
73	MP0002132_abnormal_respiratory_system	0.88802751
74	MP0005620_abnormal_muscle_contractility	0.88584728
75	MP0000537_abnormal_urethra_morphology	0.86738133
76	MP0000653_abnormal_sex_gland	0.86730638
77	MP0001730_embryonic_growth_arrest	0.86251609
78	MP0004197_abnormal_fetal_growth/weight/	0.86005010
79	MP0001485_abnormal_pinna_reflex	0.85549264
80	MP0003119_abnormal_digestive_system	0.84519350
81	MP0001835_abnormal_antigen_presentation	0.78042468
82	MP0001984_abnormal_olfaction	0.77909966
83	MP0003787_abnormal_imprinting	0.77684873
84	MP0002090_abnormal_vision	0.76818422
85	MP0001697_abnormal_embryo_size	0.76388572
86	MP0006276_abnormal_autonomic_nervous	0.75661042
87	MP0005394_taste/olfaction_phenotype	0.73512095
88	MP0005499_abnormal_olfactory_system	0.73512095
89	MP0001119_abnormal_female_reproductive	0.73171221
90	MP0003698_abnormal_male_reproductive	0.72408851
91	MP0009250_abnormal_appendicular_skeleto	0.70846824
92	MP0005380_embryogenesis_phenotype	0.70492567
93	MP0001672_abnormal_embryogenesis/_devel	0.70492567
94	MP0000613_abnormal_salivary_gland	0.70290051
95	MP0005332_abnormal_amino_acid	0.69619754
96	MP0001905_abnormal_dopamine_level	0.69600759
97	MP0002088_abnormal_embryonic_growth/wei	0.69212741
98	MP0002106_abnormal_muscle_physiology	0.68262055
99	MP0003984_embryonic_growth_retardation	0.65520506
100	MP0002269_muscular_atrophy	0.65446873

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.23437342
2	Abnormality of alanine metabolism (HP:0010916)	4.23437342
3	Hyperalaninemia (HP:0003348)	4.23437342
4	Abnormality of the labia minora (HP:0012880)	4.02605121
5	Nephronophthisis (HP:0000090)	3.35862215
6	Type I transferrin isoform profile (HP:0003642)	3.28756845
7	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.28624482
8	Abnormal protein N-linked glycosylation (HP:0012347)	3.28624482
9	Abnormal protein glycosylation (HP:0012346)	3.28624482
10	Abnormal glycosylation (HP:0012345)	3.28624482
11	Reduced antithrombin III activity (HP:0001976)	3.17452267
12	Lipid accumulation in hepatocytes (HP:0006561)	3.16673582
13	Increased hepatocellular lipid droplets (HP:0006565)	2.98837055
14	Colon cancer (HP:0003003)	2.98319336
15	Hyperglycinemia (HP:0002154)	2.96411148
16	Confusion (HP:0001289)	2.90390400
17	Meckel diverticulum (HP:0002245)	2.84333700
18	Abnormality of the ileum (HP:0001549)	2.84270087
19	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.77393661
20	Increased CSF lactate (HP:0002490)	2.72521062
21	Abnormality of serum amino acid levels (HP:0003112)	2.71248106
22	Chromsome breakage (HP:0040012)	2.69125119
23	Acute necrotizing encephalopathy (HP:0006965)	2.68771162
24	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.65561376
25	Hyperglycinuria (HP:0003108)	2.59956440
26	Mitochondrial inheritance (HP:0001427)	2.55965546
27	Exercise-induced muscle cramps (HP:0003710)	2.55747392
28	Respiratory difficulties (HP:0002880)	2.52008692
29	Molar tooth sign on MRI (HP:0002419)	2.51687124
30	Abnormality of midbrain morphology (HP:0002418)	2.51687124
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.51605165
32	Abnormality of the renal medulla (HP:0100957)	2.51045635
33	Abnormality of serine family amino acid metabolism (HP:0010894)	2.51014348
34	Abnormality of glycine metabolism (HP:0010895)	2.51014348
35	Abnormality of urine glucose concentration (HP:0011016)	2.41139549
36	Glycosuria (HP:0003076)	2.41139549
37	Central scotoma (HP:0000603)	2.40295150
38	True hermaphroditism (HP:0010459)	2.36454215
39	Acute encephalopathy (HP:0006846)	2.36119059
40	Polycythemia (HP:0001901)	2.35193758
41	Type 2 muscle fiber atrophy (HP:0003554)	2.35041880
42	Thyroid-stimulating hormone excess (HP:0002925)	2.34222462
43	Decreased central vision (HP:0007663)	2.32300730
44	Cerebral edema (HP:0002181)	2.31430691
45	Adactyly (HP:0009776)	2.30655074
46	Abnormality of the preputium (HP:0100587)	2.27850096
47	Pancreatic cysts (HP:0001737)	2.25364524
48	Increased serum lactate (HP:0002151)	2.22200277
49	Clubbing of toes (HP:0100760)	2.11511187
50	Sloping forehead (HP:0000340)	2.11494286
51	Abnormality of chromosome stability (HP:0003220)	2.11269916
52	Duodenal stenosis (HP:0100867)	2.11036246
53	Small intestinal stenosis (HP:0012848)	2.11036246
54	Pancreatic fibrosis (HP:0100732)	2.08393166
55	Hepatocellular necrosis (HP:0001404)	2.08014113
56	Dyschromatopsia (HP:0007641)	2.06286701
57	Scotoma (HP:0000575)	2.06050845
58	Abnormal mitochondria in muscle tissue (HP:0008316)	2.05720018
59	Cerebellar dysplasia (HP:0007033)	2.03755108
60	Progressive macrocephaly (HP:0004481)	2.03490767
61	Onycholysis (HP:0001806)	2.03257416
62	Triphalangeal thumb (HP:0001199)	2.02941544
63	Intestinal atresia (HP:0011100)	2.02411953
64	Renal Fanconi syndrome (HP:0001994)	2.01582469
65	Methylmalonic acidemia (HP:0002912)	2.00227910
66	Abnormality of the duodenum (HP:0002246)	1.99714892
67	Increased serum pyruvate (HP:0003542)	1.98705900
68	Exertional dyspnea (HP:0002875)	1.98172030
69	Attenuation of retinal blood vessels (HP:0007843)	1.97467509
70	Hypoplasia of the uterus (HP:0000013)	1.95690574
71	Myoglobinuria (HP:0002913)	1.94320756
72	Abnormal lung lobation (HP:0002101)	1.92884646
73	Embryonal renal neoplasm (HP:0011794)	1.91602442
74	Muscle fiber atrophy (HP:0100295)	1.91216768
75	Lethargy (HP:0001254)	1.90781953
76	Amniotic constriction ring (HP:0009775)	1.89965835
77	Abnormality of placental membranes (HP:0011409)	1.89965835
78	Supernumerary spleens (HP:0009799)	1.88476878
79	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.88177728
80	Disproportionate short-trunk short stature (HP:0003521)	1.88077009
81	Esophageal atresia (HP:0002032)	1.87983690
82	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.86250863
83	Pendular nystagmus (HP:0012043)	1.85714071
84	Hepatic necrosis (HP:0002605)	1.83897492
85	Lactic acidosis (HP:0003128)	1.83539747
86	Tubulointerstitial nephritis (HP:0001970)	1.82834697
87	Rhabdomyolysis (HP:0003201)	1.81102754
88	Aplasia/hypoplasia of the uterus (HP:0008684)	1.80270652
89	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.79350785
90	Muscle fiber inclusion bodies (HP:0100299)	1.78278058
91	Hyperammonemia (HP:0001987)	1.77758971
92	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	1.77618194
93	Carpal bone hypoplasia (HP:0001498)	1.75175849
94	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.72673672
95	Abnormality of the middle phalanges of the toes (HP:0010183)	1.70101130
96	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.68592168
97	Partial agenesis of the corpus callosum (HP:0001338)	1.68330404
98	Optic disc pallor (HP:0000543)	1.67995927
99	Oligodactyly (hands) (HP:0001180)	1.67356001
100	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.66394502

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	5.20644689
2	TSSK6	3.51162360
3	ZAK	3.37420123
4	EIF2AK3	3.04308131
5	SRPK1	2.63012743
6	PINK1	2.58270516
7	PLK4	2.56025640
8	OBSCN	2.53102847
9	TAOK3	2.47654784
10	VRK2	2.45415245
11	MKNK1	2.45080642
12	MST4	2.40209081
13	BMPR1B	2.33685239
14	TAF1	2.12596264
15	TNIK	2.07829911
16	TRIM28	1.94167258
17	NUAK1	1.81816256
18	BCKDK	1.75374851
19	EIF2AK1	1.74281415
20	PLK3	1.72464344
21	NEK9	1.71727630
22	AKT3	1.71569181
23	TGFBR1	1.69978118
24	NEK1	1.66460969
25	ACVR1B	1.64187745
26	VRK1	1.63333086
27	STK38L	1.60561207
28	PASK	1.36075860
29	GRK1	1.28517815
30	WNK3	1.25801084
31	TLK1	1.25056020
32	MAP4K2	1.23309279
33	PLK1	1.16171434
34	OXSR1	1.13856486
35	PLK2	1.06493789
36	PDK2	1.03022062
37	MUSK	1.02356863
38	TXK	0.99437674
39	CDK3	0.96846122
40	BUB1	0.95236668
41	MKNK2	0.92653276
42	NME2	0.92614668
43	RPS6KA4	0.91891839
44	WEE1	0.90888645
45	STK39	0.87784324
46	DYRK3	0.86856116
47	FRK	0.82698060
48	BCR	0.79412456
49	MAPKAPK5	0.78390794
50	SIK3	0.78112563
51	ADRBK2	0.77502549
52	TTK	0.76094814
53	MAP3K4	0.75386262
54	MAPK7	0.74751769
55	CCNB1	0.73349041
56	CSNK1G1	0.72331365
57	BRSK2	0.70050137
58	EIF2AK2	0.69404660
59	NME1	0.68225486
60	DYRK2	0.63835818
61	TIE1	0.60900247
62	WNK4	0.60855138
63	NLK	0.60600183
64	CDC7	0.57400569
65	MAP2K6	0.56171585
66	CHEK2	0.55628848
67	SGK2	0.54908148
68	PNCK	0.54698868
69	MAP2K7	0.54049875
70	CSNK1A1L	0.50055735
71	TYK2	0.48509098
72	AURKB	0.47823856
73	CSNK1G3	0.47268288
74	PRKD3	0.45746846
75	RPS6KA5	0.45725347
76	CDK8	0.44892008
77	PRKCQ	0.44056132
78	ATR	0.42876549
79	SCYL2	0.42709353
80	CSNK1G2	0.41900559
81	PHKG2	0.40061220
82	PHKG1	0.40061220
83	ATM	0.38316427
84	CSNK2A1	0.37840344
85	ERBB3	0.37397612
86	FLT3	0.36980215
87	PRKCE	0.36288623
88	DAPK1	0.35893976
89	MARK3	0.32155324
90	CSNK2A2	0.31582860
91	PIK3CG	0.31496917
92	CHEK1	0.31104638
93	AKT2	0.29934940
94	INSRR	0.29475967
95	MAPK13	0.28461420
96	MYLK	0.28096150
97	CSNK1E	0.28070863
98	CDK19	0.27698059
99	PAK4	0.27475312
100	MELK	0.25178395

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.24814133
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.96700450
3	Asthma_Homo sapiens_hsa05310	2.76983326
4	Propanoate metabolism_Homo sapiens_hsa00640	2.65982671
5	DNA replication_Homo sapiens_hsa03030	2.55086087
6	RNA degradation_Homo sapiens_hsa03018	2.52084244
7	Protein export_Homo sapiens_hsa03060	2.49088036
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.29807815
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.22716682
10	Homologous recombination_Homo sapiens_hsa03440	2.17503725
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.07857984
12	RNA polymerase_Homo sapiens_hsa03020	2.03380854
13	Basal transcription factors_Homo sapiens_hsa03022	2.01418193
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.99741269
15	Mismatch repair_Homo sapiens_hsa03430	1.99704676
16	Fatty acid elongation_Homo sapiens_hsa00062	1.93446261
17	Steroid biosynthesis_Homo sapiens_hsa00100	1.92245335
18	RNA transport_Homo sapiens_hsa03013	1.85189426
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.76652262
20	Spliceosome_Homo sapiens_hsa03040	1.75290995
21	Ribosome_Homo sapiens_hsa03010	1.72798304
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.65787336
23	Allograft rejection_Homo sapiens_hsa05330	1.62463179
24	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.55632494
25	Butanoate metabolism_Homo sapiens_hsa00650	1.50709422
26	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.50273810
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.49178566
28	Parkinsons disease_Homo sapiens_hsa05012	1.47634760
29	One carbon pool by folate_Homo sapiens_hsa00670	1.46455785
30	Oxidative phosphorylation_Homo sapiens_hsa00190	1.44747887
31	Retinol metabolism_Homo sapiens_hsa00830	1.40731351
32	Peroxisome_Homo sapiens_hsa04146	1.37276330
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.37162185
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34708797
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.31418692
36	Base excision repair_Homo sapiens_hsa03410	1.30359334
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.27624619
38	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.27317833
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.27078293
40	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.26432098
41	Nucleotide excision repair_Homo sapiens_hsa03420	1.24862029
42	Purine metabolism_Homo sapiens_hsa00230	1.22693110
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.18209298
44	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.16395653
45	Arginine and proline metabolism_Homo sapiens_hsa00330	1.11429184
46	Fatty acid degradation_Homo sapiens_hsa00071	1.05074145
47	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.04160787
48	Pyruvate metabolism_Homo sapiens_hsa00620	1.03859530
49	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.00810774
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.00726038
51	Fatty acid metabolism_Homo sapiens_hsa01212	0.99288223
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.98048574
53	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.92616219
54	mRNA surveillance pathway_Homo sapiens_hsa03015	0.92455863
55	Huntingtons disease_Homo sapiens_hsa05016	0.88221052
56	Phototransduction_Homo sapiens_hsa04744	0.84616178
57	Glutathione metabolism_Homo sapiens_hsa00480	0.84511192
58	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.83344423
59	Carbon metabolism_Homo sapiens_hsa01200	0.80103853
60	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.72022362
61	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.70379540
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.70019724
63	Arginine biosynthesis_Homo sapiens_hsa00220	0.69883388
64	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.69310271
65	Metabolic pathways_Homo sapiens_hsa01100	0.69081358
66	Cell cycle_Homo sapiens_hsa04110	0.68128108
67	Type I diabetes mellitus_Homo sapiens_hsa04940	0.67873269
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67619816
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65263001
70	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.63989310
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63050036
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.62483559
73	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.62328265
74	Graft-versus-host disease_Homo sapiens_hsa05332	0.61756159
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61252915
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61230539
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.60897349
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60532655
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.59815169
80	Caffeine metabolism_Homo sapiens_hsa00232	0.57592435
81	Antigen processing and presentation_Homo sapiens_hsa04612	0.57213810
82	Alzheimers disease_Homo sapiens_hsa05010	0.56993945
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.56898786
84	Basal cell carcinoma_Homo sapiens_hsa05217	0.56833038
85	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49629934
86	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.48940064
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46784293
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44576178
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42355704
90	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.40545466
91	Sulfur metabolism_Homo sapiens_hsa00920	0.38262347
92	Circadian rhythm_Homo sapiens_hsa04710	0.35323579
93	p53 signaling pathway_Homo sapiens_hsa04115	0.34019817
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.29447142
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.28699250
96	Regulation of autophagy_Homo sapiens_hsa04140	0.28601096
97	Lysine degradation_Homo sapiens_hsa00310	0.28037800
98	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.27577083
99	Folate biosynthesis_Homo sapiens_hsa00790	0.27191853
100	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.25061063

HNRNPA1P66

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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