ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.94996609
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.52825458
3	regulation of isotype switching to IgG isotypes (GO:0048302)	5.43505946
4	water-soluble vitamin biosynthetic process (GO:0042364)	4.99041895
5	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.29209835
6	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.24047008
7	protein neddylation (GO:0045116)	4.12155218
8	protein deneddylation (GO:0000338)	4.05246580
9	cullin deneddylation (GO:0010388)	3.98707429
10	chaperone-mediated protein transport (GO:0072321)	3.91514111
11	proteasome assembly (GO:0043248)	3.90548036
12	L-fucose metabolic process (GO:0042354)	3.90490055
13	L-fucose catabolic process (GO:0042355)	3.90490055
14	fucose catabolic process (GO:0019317)	3.90490055
15	ribosome assembly (GO:0042255)	3.83320450
16	tRNA methylation (GO:0030488)	3.79932508
17	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.72896793
18	isotype switching (GO:0045190)	3.72896793
19	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.72896793
20	pseudouridine synthesis (GO:0001522)	3.70199071
21	regulation of helicase activity (GO:0051095)	3.61792723
22	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.47870267
23	rRNA modification (GO:0000154)	3.47573000
24	regulation of podosome assembly (GO:0071801)	3.44725402
25	tRNA processing (GO:0008033)	3.43875851
26	DNA replication checkpoint (GO:0000076)	3.43006658
27	tRNA aminoacylation for protein translation (GO:0006418)	3.40002006
28	ribosome biogenesis (GO:0042254)	3.37449607
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.37192515
30	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.37192515
31	tRNA aminoacylation (GO:0043039)	3.36577357
32	amino acid activation (GO:0043038)	3.36577357
33	DNA replication-dependent nucleosome organization (GO:0034723)	3.36269361
34	DNA replication-dependent nucleosome assembly (GO:0006335)	3.36269361
35	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.35770683
36	tRNA modification (GO:0006400)	3.29426240
37	rRNA processing (GO:0006364)	3.27778182
38	ATP synthesis coupled proton transport (GO:0015986)	3.25567581
39	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.25567581
40	rRNA metabolic process (GO:0016072)	3.25229946
41	tRNA metabolic process (GO:0006399)	3.25157490
42	regulation of cellular amino acid metabolic process (GO:0006521)	3.23744592
43	positive regulation of isotype switching (GO:0045830)	3.23513340
44	response to pheromone (GO:0019236)	3.21374099
45	tetrahydrofolate metabolic process (GO:0046653)	3.18987903
46	mitochondrial calcium ion transport (GO:0006851)	3.16337153
47	kinetochore assembly (GO:0051382)	3.14120891
48	rRNA catabolic process (GO:0016075)	3.09975295
49	regulation of immunoglobulin secretion (GO:0051023)	3.09121000
50	somatic recombination of immunoglobulin gene segments (GO:0016447)	3.07933324
51	protein complex biogenesis (GO:0070271)	3.07342799
52	chromatin remodeling at centromere (GO:0031055)	3.02538256
53	folic acid-containing compound biosynthetic process (GO:0009396)	3.01026501
54	ncRNA processing (GO:0034470)	3.00913527
55	negative regulation of ligase activity (GO:0051352)	3.00565899
56	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.00565899
57	ncRNA metabolic process (GO:0034660)	3.00122468
58	protein localization to mitochondrion (GO:0070585)	2.99416807
59	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.97530722
60	mitochondrial respiratory chain complex assembly (GO:0033108)	2.97330219
61	rRNA methylation (GO:0031167)	2.96796180
62	maturation of SSU-rRNA (GO:0030490)	2.96221517
63	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.96128740
64	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.95104105
65	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.93325544
66	positive regulation of DNA recombination (GO:0045911)	2.92392121
67	kinetochore organization (GO:0051383)	2.90121169
68	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.89791442
69	S-adenosylmethionine metabolic process (GO:0046500)	2.89621930
70	somatic diversification of immunoglobulins (GO:0016445)	2.86768013
71	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.85556974
72	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.85429092
73	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.85429092
74	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.85429092
75	protein targeting to mitochondrion (GO:0006626)	2.84648790
76	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.84541243
77	CENP-A containing nucleosome assembly (GO:0034080)	2.84154646
78	spliceosomal complex assembly (GO:0000245)	2.84139935
79	establishment of protein localization to mitochondrion (GO:0072655)	2.83558803
80	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.83433869
81	spliceosomal snRNP assembly (GO:0000387)	2.83059657
82	ncRNA catabolic process (GO:0034661)	2.82997867
83	telomere maintenance via semi-conservative replication (GO:0032201)	2.79123066
84	ribosomal large subunit biogenesis (GO:0042273)	2.78637624
85	homocysteine metabolic process (GO:0050667)	2.78256881
86	positive regulation of immunoglobulin production (GO:0002639)	2.78255621
87	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.78063507
88	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.78063507
89	negative regulation of telomere maintenance (GO:0032205)	2.75767713
90	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.75469637
91	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.75211446
92	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.75211446
93	intracellular protein transmembrane import (GO:0044743)	2.75138344
94	cellular component biogenesis (GO:0044085)	2.74940671
95	ribonucleoprotein complex biogenesis (GO:0022613)	2.73644781
96	maturation of 5.8S rRNA (GO:0000460)	2.73446543
97	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.72785051
98	DNA strand elongation involved in DNA replication (GO:0006271)	2.71955675
99	GMP metabolic process (GO:0046037)	2.71953532
100	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.71212391

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.59016152
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.76340740
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.68535693
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.59992182
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.49158369
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.43387283
7	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.15716106
8	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	3.07152059
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.95326510
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.89987738
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.87922196
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.85729008
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.81297672
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.79681372
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.75706731
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.75333175
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.73988634
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.57549112
19	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.46018285
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.36514742
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.29239664
22	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.23746062
23	ELK1_19687146_ChIP-ChIP_HELA_Human	2.18911390
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.07515739
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06687568
26	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.06438396
27	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.06369747
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.04747656
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.02972720
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.96705295
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.94875528
32	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.92303489
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.89935496
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.87817663
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.80418187
36	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.77747496
37	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.68010359
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.67798983
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.67250948
40	DCP1A_22483619_ChIP-Seq_HELA_Human	1.65184597
41	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.64817015
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61173779
43	XRN2_22483619_ChIP-Seq_HELA_Human	1.57579705
44	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.54480186
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.51618480
46	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.50232313
47	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.44852720
48	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.44148246
49	EWS_26573619_Chip-Seq_HEK293_Human	1.42860591
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.42830287
51	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38201912
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.38117074
53	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.33204559
54	ZNF274_21170338_ChIP-Seq_K562_Hela	1.30306734
55	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.29194915
56	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.29053323
57	VDR_22108803_ChIP-Seq_LS180_Human	1.28331235
58	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.24445062
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21115762
60	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.19777411
61	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.19043378
62	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.18676953
63	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.18402857
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.15669291
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15438477
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.14419078
67	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.13010975
68	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.12960780
69	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.07556413
70	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.07081129
71	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.06306589
72	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03007797
73	IGF1R_20145208_ChIP-Seq_DFB_Human	1.02791742
74	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.00440883
75	TAF15_26573619_Chip-Seq_HEK293_Human	0.98828244
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98277786
77	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.98263942
78	AR_21909140_ChIP-Seq_LNCAP_Human	0.98025658
79	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.97201275
80	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.95937453
81	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.92104831
82	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.91679889
83	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.90560088
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.86896184
85	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.86128283
86	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.85284502
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.84351594
88	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.81634365
89	FUS_26573619_Chip-Seq_HEK293_Human	0.80817664
90	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.79054993
91	GATA3_26560356_Chip-Seq_TH2_Human	0.78751142
92	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.77591594
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.77565333
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.77565333
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.77171043
96	HTT_18923047_ChIP-ChIP_STHdh_Human	0.76820481
97	PHF8_20622853_ChIP-Seq_HELA_Human	0.76473328
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.75425707
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.75425707
100	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.74995263

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	4.28249407
2	MP0003646_muscle_fatigue	3.59639294
3	MP0001873_stomach_inflammation	3.04731053
4	MP0001348_abnormal_lacrimal_gland	3.03147060
5	MP0008877_abnormal_DNA_methylation	3.03055624
6	MP0006072_abnormal_retinal_apoptosis	2.84301435
7	MP0003693_abnormal_embryo_hatching	2.83344275
8	MP0005671_abnormal_response_to	2.79376124
9	MP0002102_abnormal_ear_morphology	2.76962408
10	MP0004957_abnormal_blastocyst_morpholog	2.70725249
11	MP0001835_abnormal_antigen_presentation	2.59547213
12	MP0000372_irregular_coat_pigmentation	2.57779524
13	MP0006292_abnormal_olfactory_placode	2.56460162
14	MP0004147_increased_porphyrin_level	2.44659236
15	MP0008872_abnormal_physiological_respon	2.25128322
16	MP0005084_abnormal_gallbladder_morpholo	2.24278935
17	MP0002138_abnormal_hepatobiliary_system	2.21869295
18	MP0003111_abnormal_nucleus_morphology	2.08566455
19	MP0002254_reproductive_system_inflammat	2.04438909
20	MP0010094_abnormal_chromosome_stability	2.01919542
21	MP0003878_abnormal_ear_physiology	1.99627500
22	MP0005377_hearing/vestibular/ear_phenot	1.99627500
23	MP0003283_abnormal_digestive_organ	1.96736870
24	MP0004885_abnormal_endolymph	1.90481446
25	MP0008875_abnormal_xenobiotic_pharmacok	1.86162169
26	MP0000685_abnormal_immune_system	1.70438483
27	MP0008058_abnormal_DNA_repair	1.65141150
28	MP0008057_abnormal_DNA_replication	1.50338064
29	MP0009697_abnormal_copulation	1.48945458
30	MP0001666_abnormal_nutrient_absorption	1.46596658
31	MP0001293_anophthalmia	1.39290932
32	MP0002736_abnormal_nociception_after	1.38745116
33	MP0001764_abnormal_homeostasis	1.36293536
34	MP0005075_abnormal_melanosome_morpholog	1.35170096
35	MP0006036_abnormal_mitochondrial_physio	1.34937055
36	MP0005646_abnormal_pituitary_gland	1.34332757
37	MP0003195_calcinosis	1.33844821
38	MP0003806_abnormal_nucleotide_metabolis	1.27498285
39	MP0003119_abnormal_digestive_system	1.26464673
40	MP0002163_abnormal_gland_morphology	1.15250153
41	MP0001881_abnormal_mammary_gland	1.14268421
42	MP0005220_abnormal_exocrine_pancreas	1.14185906
43	MP0001919_abnormal_reproductive_system	1.13515234
44	MP0006082_CNS_inflammation	1.11387413
45	MP0008775_abnormal_heart_ventricle	1.11130728
46	MP0003567_abnormal_fetal_cardiomyocyte	1.10633830
47	MP0001968_abnormal_touch/_nociception	1.09626460
48	MP0003077_abnormal_cell_cycle	1.08538048
49	MP0005000_abnormal_immune_tolerance	1.06850903
50	MP0002693_abnormal_pancreas_physiology	1.06374976
51	MP0003786_premature_aging	1.06211205
52	MP0003186_abnormal_redox_activity	1.05179823
53	MP0004019_abnormal_vitamin_homeostasis	1.05081627
54	MP0000537_abnormal_urethra_morphology	1.04980264
55	MP0003718_maternal_effect	1.04861029
56	MP0010307_abnormal_tumor_latency	1.01736821
57	MP0004145_abnormal_muscle_electrophysio	1.01378523
58	MP0001790_abnormal_immune_system	1.00532264
59	MP0005387_immune_system_phenotype	1.00532264
60	MP0001661_extended_life_span	1.00326619
61	MP0005253_abnormal_eye_physiology	0.98027707
62	MP0005389_reproductive_system_phenotype	0.97687750
63	MP0005332_abnormal_amino_acid	0.95934530
64	MP0009278_abnormal_bone_marrow	0.93797698
65	MP0001529_abnormal_vocalization	0.92124510
66	MP0008789_abnormal_olfactory_epithelium	0.89913944
67	MP0001986_abnormal_taste_sensitivity	0.88301423
68	MP0008932_abnormal_embryonic_tissue	0.88204686
69	MP0009333_abnormal_splenocyte_physiolog	0.85508670
70	MP0000631_abnormal_neuroendocrine_gland	0.84355011
71	MP0003122_maternal_imprinting	0.84134920
72	MP0006035_abnormal_mitochondrial_morpho	0.80456981
73	MP0001727_abnormal_embryo_implantation	0.79612772
74	MP0000689_abnormal_spleen_morphology	0.79454697
75	MP0005410_abnormal_fertilization	0.79371860
76	MP0001188_hyperpigmentation	0.79162029
77	MP0008007_abnormal_cellular_replicative	0.77821157
78	MP0002148_abnormal_hypersensitivity_rea	0.77375269
79	MP0002876_abnormal_thyroid_physiology	0.77318396
80	MP0002210_abnormal_sex_determination	0.75775252
81	MP0003943_abnormal_hepatobiliary_system	0.72360849
82	MP0000313_abnormal_cell_death	0.71245199
83	MP0000383_abnormal_hair_follicle	0.70521313
84	MP0002938_white_spotting	0.70291640
85	MP0002006_tumorigenesis	0.69601747
86	MP0005551_abnormal_eye_electrophysiolog	0.69573474
87	MP0002019_abnormal_tumor_incidence	0.68793546
88	MP0002234_abnormal_pharynx_morphology	0.68792866
89	MP0005636_abnormal_mineral_homeostasis	0.68222637
90	MP0005083_abnormal_biliary_tract	0.68080470
91	MP0005310_abnormal_salivary_gland	0.67476763
92	MP0001800_abnormal_humoral_immune	0.65236868
93	MP0002398_abnormal_bone_marrow	0.64859568
94	MP0004133_heterotaxia	0.64045643
95	MP0004742_abnormal_vestibular_system	0.63322228
96	MP0002166_altered_tumor_susceptibility	0.62579147
97	MP0004782_abnormal_surfactant_physiolog	0.62342921
98	MP0002132_abnormal_respiratory_system	0.62092543
99	MP0001697_abnormal_embryo_size	0.61574468
100	MP0000015_abnormal_ear_pigmentation	0.61412073

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.63506904
2	Hypomagnesemia (HP:0002917)	4.20522030
3	Acute encephalopathy (HP:0006846)	4.08031660
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.99148972
5	Progressive macrocephaly (HP:0004481)	3.77433987
6	Increased IgM level (HP:0003496)	3.74275541
7	Abnormality of magnesium homeostasis (HP:0004921)	3.69460305
8	Mitochondrial inheritance (HP:0001427)	3.63117227
9	Increased CSF lactate (HP:0002490)	3.57777215
10	Type 2 muscle fiber atrophy (HP:0003554)	3.53700869
11	Increased hepatocellular lipid droplets (HP:0006565)	3.45591481
12	Hypoplasia of the pons (HP:0012110)	3.31097180
13	Methylmalonic acidemia (HP:0002912)	3.21758764
14	Abnormality of the pons (HP:0007361)	3.16803384
15	Increased serum lactate (HP:0002151)	3.13169008
16	Hyperglycinemia (HP:0002154)	3.10646053
17	Lipid accumulation in hepatocytes (HP:0006561)	3.03858619
18	Cerebral edema (HP:0002181)	3.03775469
19	Muscle fiber atrophy (HP:0100295)	3.01679838
20	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.95856742
21	Colon cancer (HP:0003003)	2.80684761
22	Delayed CNS myelination (HP:0002188)	2.77008807
23	Hepatocellular necrosis (HP:0001404)	2.73278916
24	Abnormal hemoglobin (HP:0011902)	2.67959569
25	Methylmalonic aciduria (HP:0012120)	2.63077233
26	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.62241185
27	Hypoproteinemia (HP:0003075)	2.59354842
28	Hepatic necrosis (HP:0002605)	2.57091069
29	Asplenia (HP:0001746)	2.56608328
30	IgG deficiency (HP:0004315)	2.51363367
31	Increased intramyocellular lipid droplets (HP:0012240)	2.51236592
32	Lactic acidosis (HP:0003128)	2.45873127
33	Aplasia/hypoplasia of the uterus (HP:0008684)	2.44437321
34	Optic disc pallor (HP:0000543)	2.43171898
35	Abnormality of midbrain morphology (HP:0002418)	2.43053544
36	Molar tooth sign on MRI (HP:0002419)	2.43053544
37	Abnormal number of erythroid precursors (HP:0012131)	2.36876099
38	Pancreatic cysts (HP:0001737)	2.35290943
39	Exercise intolerance (HP:0003546)	2.25957484
40	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.23789166
41	Exertional dyspnea (HP:0002875)	2.23656889
42	Poor head control (HP:0002421)	2.23083011
43	Leukodystrophy (HP:0002415)	2.20261825
44	Abnormality of cells of the erythroid lineage (HP:0012130)	2.15229630
45	Renal Fanconi syndrome (HP:0001994)	2.13449739
46	Respiratory failure (HP:0002878)	2.11529120
47	Abnormality of serine family amino acid metabolism (HP:0010894)	2.09427204
48	Abnormality of glycine metabolism (HP:0010895)	2.09427204
49	Abolished electroretinogram (ERG) (HP:0000550)	2.08795639
50	True hermaphroditism (HP:0010459)	2.07697229
51	Carpal bone hypoplasia (HP:0001498)	2.06281946
52	Nephronophthisis (HP:0000090)	2.05641168
53	Abnormality of serum amino acid levels (HP:0003112)	2.04063852
54	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.03849516
55	Lethargy (HP:0001254)	2.03380737
56	Abnormality of the ileum (HP:0001549)	2.02311346
57	Meckel diverticulum (HP:0002245)	2.00638115
58	Abnormality of the labia minora (HP:0012880)	1.99954476
59	Prostate neoplasm (HP:0100787)	1.98711333
60	Abnormality of T cell physiology (HP:0011840)	1.96502593
61	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.96111167
62	Hypoplasia of the fovea (HP:0007750)	1.96111167
63	Increased muscle lipid content (HP:0009058)	1.90982509
64	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.90784408
65	Abnormality of the fovea (HP:0000493)	1.90188158
66	Death in infancy (HP:0001522)	1.88520120
67	Glycosuria (HP:0003076)	1.88318484
68	Abnormality of urine glucose concentration (HP:0011016)	1.88318484
69	Absent thumb (HP:0009777)	1.87785421
70	Fused cervical vertebrae (HP:0002949)	1.86536600
71	Poor suck (HP:0002033)	1.86274364
72	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.85599200
73	Polyuria (HP:0000103)	1.84161945
74	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.84126615
75	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.84126615
76	Aplasia/hypoplasia of the humerus (HP:0006507)	1.84069037
77	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.83410799
78	Abnormality of the prostate (HP:0008775)	1.82834495
79	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.81578484
80	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.80640116
81	Short 1st metacarpal (HP:0010034)	1.80640116
82	Cerebral palsy (HP:0100021)	1.79875916
83	Mesangial abnormality (HP:0001966)	1.79846257
84	Supernumerary spleens (HP:0009799)	1.77818692
85	Pendular nystagmus (HP:0012043)	1.77290082
86	Pancreatic fibrosis (HP:0100732)	1.75638014
87	Progressive muscle weakness (HP:0003323)	1.75345523
88	Medial flaring of the eyebrow (HP:0010747)	1.74508434
89	Tubular atrophy (HP:0000092)	1.74286427
90	Abnormality of the renal medulla (HP:0100957)	1.74285063
91	Multiple enchondromatosis (HP:0005701)	1.73487674
92	Progressive microcephaly (HP:0000253)	1.73215830
93	Hypoplasia of the uterus (HP:0000013)	1.72954991
94	Abnormality of DNA repair (HP:0003254)	1.71352706
95	Stomatitis (HP:0010280)	1.68596822
96	Congenital, generalized hypertrichosis (HP:0004540)	1.68398683
97	Pallor (HP:0000980)	1.68193164
98	Abnormality of the renal cortex (HP:0011035)	1.66813088
99	Eosinophilia (HP:0001880)	1.66213395
100	Fibular aplasia (HP:0002990)	1.66112886

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.30363200
2	EIF2AK1	3.17524358
3	MST4	2.95907488
4	TSSK6	2.93733884
5	ZAK	2.90070142
6	PBK	2.82871119
7	NUAK1	2.80584359
8	SRPK1	2.70751648
9	MAP4K2	2.68158932
10	TLK1	2.64889263
11	CDC7	2.54577127
12	EIF2AK3	2.44032750
13	MKNK1	2.09873787
14	BUB1	2.01323567
15	MKNK2	2.00493925
16	NEK1	1.90599211
17	EIF2AK2	1.90300331
18	ACVR1B	1.89796823
19	NME1	1.84793158
20	BCR	1.78837888
21	PASK	1.77955909
22	TXK	1.76424656
23	TAF1	1.76212303
24	BMPR1B	1.63246709
25	PLK3	1.60809649
26	RIPK4	1.57982058
27	KDR	1.56166985
28	BRD4	1.54065545
29	TNIK	1.50201155
30	STK24	1.46934845
31	STK16	1.42550564
32	MAP3K14	1.38751141
33	WNK3	1.36249826
34	SIK2	1.36143734
35	NEK2	1.34146683
36	MAP4K1	1.24451702
37	STK38L	1.23451403
38	VRK1	1.22708776
39	MAP3K4	1.21549253
40	ADRBK2	1.19605622
41	TRIM28	1.11391120
42	OXSR1	1.04162341
43	PLK1	1.02190790
44	IKBKB	0.99865652
45	PLK4	0.96974182
46	TIE1	0.96954075
47	KIT	0.93817996
48	TTK	0.93421441
49	ALK	0.92137923
50	PINK1	0.91271786
51	TAOK3	0.90118159
52	STK39	0.90093739
53	GRK1	0.85906090
54	STK4	0.85806780
55	WEE1	0.83128529
56	CDK3	0.81274486
57	SMG1	0.79901025
58	MAPK13	0.77362106
59	STK3	0.76365900
60	AURKB	0.76044739
61	IKBKE	0.73331158
62	GRK6	0.71029882
63	ATR	0.70710287
64	MAP2K6	0.68820926
65	MELK	0.68480952
66	CSNK1G3	0.68185501
67	TRPM7	0.66505104
68	TBK1	0.59666923
69	FLT3	0.58891881
70	TGFBR1	0.57668580
71	CHEK2	0.56473668
72	RPS6KA5	0.54614743
73	RPS6KA4	0.54549270
74	PRKCQ	0.52772060
75	WNK4	0.52069411
76	ITK	0.51922671
77	CSNK1G2	0.51319526
78	CSNK2A1	0.47956989
79	DYRK3	0.46566940
80	NME2	0.45927961
81	CSNK1A1L	0.44820651
82	CDK4	0.43472239
83	DAPK1	0.43207818
84	ATM	0.43151897
85	CHEK1	0.42546050
86	CHUK	0.40916789
87	CSNK1G1	0.40505137
88	PHKG1	0.37665388
89	PHKG2	0.37665388
90	JAK3	0.37329192
91	CSNK2A2	0.35057479
92	CSF1R	0.33168263
93	FRK	0.33049396
94	DYRK2	0.32995916
95	MAP2K2	0.32951881
96	SYK	0.30815617
97	PLK2	0.27373258
98	CSNK1D	0.26475495
99	MAP2K7	0.26059295
100	PDK2	0.23862107

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.11504936
2	Asthma_Homo sapiens_hsa05310	3.50791265
3	Allograft rejection_Homo sapiens_hsa05330	3.23156932
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.86223846
5	Protein export_Homo sapiens_hsa03060	2.70467084
6	Mismatch repair_Homo sapiens_hsa03430	2.66127048
7	One carbon pool by folate_Homo sapiens_hsa00670	2.58742587
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.56522395
9	DNA replication_Homo sapiens_hsa03030	2.47546416
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.46310801
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.42414593
12	RNA polymerase_Homo sapiens_hsa03020	2.33459131
13	Ribosome_Homo sapiens_hsa03010	2.26700035
14	Graft-versus-host disease_Homo sapiens_hsa05332	2.25147103
15	Oxidative phosphorylation_Homo sapiens_hsa00190	2.15377636
16	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.06135687
17	RNA degradation_Homo sapiens_hsa03018	2.05741336
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.97579146
19	Spliceosome_Homo sapiens_hsa03040	1.94316513
20	Type I diabetes mellitus_Homo sapiens_hsa04940	1.84157955
21	RNA transport_Homo sapiens_hsa03013	1.72980424
22	Antigen processing and presentation_Homo sapiens_hsa04612	1.71733105
23	Parkinsons disease_Homo sapiens_hsa05012	1.69346686
24	Basal transcription factors_Homo sapiens_hsa03022	1.66272628
25	Homologous recombination_Homo sapiens_hsa03440	1.58493875
26	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.39824252
27	Base excision repair_Homo sapiens_hsa03410	1.38322587
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.37985239
29	Propanoate metabolism_Homo sapiens_hsa00640	1.36034334
30	Pyruvate metabolism_Homo sapiens_hsa00620	1.33285510
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28674824
32	Sulfur metabolism_Homo sapiens_hsa00920	1.28508486
33	Huntingtons disease_Homo sapiens_hsa05016	1.22580124
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.22269954
35	Phototransduction_Homo sapiens_hsa04744	1.18345193
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.18038297
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.14097614
38	Purine metabolism_Homo sapiens_hsa00230	1.13666149
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13264279
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.09934948
41	Caffeine metabolism_Homo sapiens_hsa00232	1.09288056
42	Linoleic acid metabolism_Homo sapiens_hsa00591	1.07701795
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03966295
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.03827326
45	Rheumatoid arthritis_Homo sapiens_hsa05323	1.01659276
46	Selenocompound metabolism_Homo sapiens_hsa00450	1.00244082
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.89765204
48	Alzheimers disease_Homo sapiens_hsa05010	0.89500597
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.89353495
50	Primary immunodeficiency_Homo sapiens_hsa05340	0.86989827
51	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83149127
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.81345857
53	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.74901406
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.72468822
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71383252
56	Viral myocarditis_Homo sapiens_hsa05416	0.71158177
57	Cell cycle_Homo sapiens_hsa04110	0.67285885
58	Folate biosynthesis_Homo sapiens_hsa00790	0.63906084
59	mRNA surveillance pathway_Homo sapiens_hsa03015	0.62578726
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.61680163
61	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.61543181
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60860562
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.59443512
64	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.58619517
65	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.58369844
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56732619
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.56379009
68	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.55882650
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.54185526
70	Herpes simplex infection_Homo sapiens_hsa05168	0.53380662
71	Peroxisome_Homo sapiens_hsa04146	0.52264063
72	Metabolic pathways_Homo sapiens_hsa01100	0.49549454
73	Regulation of autophagy_Homo sapiens_hsa04140	0.44643126
74	Leishmaniasis_Homo sapiens_hsa05140	0.43941526
75	p53 signaling pathway_Homo sapiens_hsa04115	0.43832040
76	Glutathione metabolism_Homo sapiens_hsa00480	0.43242342
77	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.41741967
78	Retinol metabolism_Homo sapiens_hsa00830	0.39265316
79	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.38514373
80	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.36918789
81	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36427046
82	Butanoate metabolism_Homo sapiens_hsa00650	0.36098405
83	Cardiac muscle contraction_Homo sapiens_hsa04260	0.35483129
84	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.34360309
85	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34174268
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.34139377
87	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32333810
88	Carbon metabolism_Homo sapiens_hsa01200	0.30490732
89	Nicotine addiction_Homo sapiens_hsa05033	0.29643988
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.28538568
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.26913887
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.25645702
93	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.23610283
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.23413519
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.22562858
96	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.22057414
97	Measles_Homo sapiens_hsa05162	0.20455549
98	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.19119883
99	Sulfur relay system_Homo sapiens_hsa04122	0.19053650
100	Chemical carcinogenesis_Homo sapiens_hsa05204	0.18331269

HNRNPA1P67

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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