ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	monoubiquitinated protein deubiquitination (GO:0035520)	6.23301451
2	piRNA metabolic process (GO:0034587)	5.16815754
3	synapsis (GO:0007129)	4.72745539
4	rRNA modification (GO:0000154)	4.47384665
5	rRNA methylation (GO:0031167)	4.38717603
6	histone H3-K4 trimethylation (GO:0080182)	4.05290262
7	pseudouridine synthesis (GO:0001522)	4.04424197
8	regulation of meiosis I (GO:0060631)	4.04121004
9	male meiosis I (GO:0007141)	3.97521380
10	regulation of immunoglobulin secretion (GO:0051023)	3.90034566
11	tryptophan metabolic process (GO:0006568)	3.88281625
12	histone H3-K4 methylation (GO:0051568)	3.78465744
13	regulation of regulatory T cell differentiation (GO:0045589)	3.71985150
14	regulation of translational termination (GO:0006449)	3.71575964
15	positive regulation of DNA recombination (GO:0045911)	3.69895253
16	positive regulation of developmental pigmentation (GO:0048087)	3.67734250
17	meiosis I (GO:0007127)	3.61597266
18	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.55415577
19	positive regulation of B cell mediated immunity (GO:0002714)	3.49927806
20	positive regulation of immunoglobulin mediated immune response (GO:0002891)	3.49927806
21	chromosome organization involved in meiosis (GO:0070192)	3.42415555
22	modulation of growth of symbiont involved in interaction with host (GO:0044144)	3.40141130
23	regulation of growth of symbiont in host (GO:0044126)	3.40141130
24	negative regulation of growth of symbiont in host (GO:0044130)	3.40141130
25	negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	3.40141130
26	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.40138204
27	maturation of SSU-rRNA (GO:0030490)	3.37763499
28	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.34865683
29	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.34865683
30	regulation of translation, ncRNA-mediated (GO:0045974)	3.34865683
31	indolalkylamine metabolic process (GO:0006586)	3.34104453
32	DNA synthesis involved in DNA repair (GO:0000731)	3.31353579
33	peptidyl-lysine trimethylation (GO:0018023)	3.29140397
34	cell wall macromolecule catabolic process (GO:0016998)	3.27456350
35	negative T cell selection (GO:0043383)	3.25395589
36	neutrophil mediated immunity (GO:0002446)	3.24433888
37	reciprocal meiotic recombination (GO:0007131)	3.21870659
38	reciprocal DNA recombination (GO:0035825)	3.21870659
39	protein prenylation (GO:0018342)	3.19465061
40	prenylation (GO:0097354)	3.19465061
41	regulation of MHC class II biosynthetic process (GO:0045346)	3.17112338
42	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.16380442
43	male meiosis (GO:0007140)	3.14721309
44	regulation of cilium movement (GO:0003352)	3.11895480
45	negative regulation of T cell mediated immunity (GO:0002710)	3.09683619
46	histone H2A acetylation (GO:0043968)	3.09609993
47	DNA methylation involved in gamete generation (GO:0043046)	3.08155919
48	regulation of chronic inflammatory response (GO:0002676)	3.07710607
49	snRNA transcription (GO:0009301)	3.04010722
50	positive regulation of granulocyte differentiation (GO:0030854)	3.03482834
51	fucose catabolic process (GO:0019317)	3.03447056
52	L-fucose metabolic process (GO:0042354)	3.03447056
53	L-fucose catabolic process (GO:0042355)	3.03447056
54	meiotic nuclear division (GO:0007126)	3.00724040
55	positive T cell selection (GO:0043368)	2.99720509
56	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.97413251
57	positive regulation of T cell cytokine production (GO:0002726)	2.95642104
58	signal peptide processing (GO:0006465)	2.93921402
59	gene silencing by RNA (GO:0031047)	2.90709362
60	positive regulation of isotype switching (GO:0045830)	2.85854324
61	histone H3-K36 demethylation (GO:0070544)	2.85311268
62	cellular extravasation (GO:0045123)	2.83816921
63	regulation of pigment cell differentiation (GO:0050932)	2.82267270
64	double-strand break repair via homologous recombination (GO:0000724)	2.81274298
65	superoxide anion generation (GO:0042554)	2.81152620
66	embryonic hemopoiesis (GO:0035162)	2.81080395
67	cell wall macromolecule metabolic process (GO:0044036)	2.80488645
68	recombinational repair (GO:0000725)	2.79105775
69	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.78813402
70	otic vesicle formation (GO:0030916)	2.78430342
71	regulation of B cell mediated immunity (GO:0002712)	2.78144940
72	regulation of MHC class I biosynthetic process (GO:0045343)	2.78119572
73	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	2.76196780
74	cytokine biosynthetic process (GO:0042089)	2.75534318
75	muscle organ morphogenesis (GO:0048644)	2.73948517
76	positive regulation of immunoglobulin production (GO:0002639)	2.73834866
77	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.72032892
78	attachment of spindle microtubules to kinetochore (GO:0008608)	2.71799298
79	regulation of immunoglobulin mediated immune response (GO:0002889)	2.71360270
80	DNA deamination (GO:0045006)	2.70019249
81	positive regulation of humoral immune response (GO:0002922)	2.69886839
82	mitochondrial respiratory chain complex assembly (GO:0033108)	2.66439809
83	hepatocyte apoptotic process (GO:0097284)	2.65440603
84	protein complex biogenesis (GO:0070271)	2.61767763
85	respiratory chain complex IV assembly (GO:0008535)	2.61594745
86	meiotic cell cycle process (GO:1903046)	2.60389847
87	regulation of isotype switching to IgG isotypes (GO:0048302)	2.58432778
88	polyol catabolic process (GO:0046174)	2.58020400
89	synaptonemal complex organization (GO:0070193)	2.56862257
90	regulation of interleukin-8 biosynthetic process (GO:0045414)	2.56666294
91	tachykinin receptor signaling pathway (GO:0007217)	2.56532503
92	peptidyl-lysine methylation (GO:0018022)	2.56459538
93	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.56059146
94	positive regulation of T cell chemotaxis (GO:0010820)	2.55240659
95	regulation of T cell chemotaxis (GO:0010819)	2.55240659
96	activated T cell proliferation (GO:0050798)	2.52891296
97	synaptonemal complex assembly (GO:0007130)	2.52009433
98	myeloid leukocyte mediated immunity (GO:0002444)	2.51303322
99	positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)	2.48817261
100	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.48683551

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.75713519
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.68931353
3	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.59264416
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.58311658
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.51712648
6	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.42111795
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.40214294
8	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.30614759
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.25901253
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.24293411
11	E2F7_22180533_ChIP-Seq_HELA_Human	2.22474750
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.19779373
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.18853971
14	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.17978743
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.09659906
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.09197986
17	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.08122280
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.02740380
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.99566448
20	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.97121875
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.95393107
22	EWS_26573619_Chip-Seq_HEK293_Human	1.95165158
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.88489821
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.85918660
25	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.84083570
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.81843984
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.80654088
28	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.80524750
29	TP53_16413492_ChIP-PET_HCT116_Human	1.80452449
30	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.74957918
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.74030432
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.72428260
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.71628236
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.69710604
35	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.68033990
36	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.64043905
37	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.63843473
38	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.56567083
39	MYB_26560356_Chip-Seq_TH2_Human	1.56538463
40	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.55997676
41	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.53730277
42	TAF15_26573619_Chip-Seq_HEK293_Human	1.53269920
43	GATA1_22025678_ChIP-Seq_K562_Human	1.51544288
44	FUS_26573619_Chip-Seq_HEK293_Human	1.51388638
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.51280451
46	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.46442409
47	P300_19829295_ChIP-Seq_ESCs_Human	1.46057233
48	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.42303331
49	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.39558658
50	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.39399837
51	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.39124904
52	VDR_22108803_ChIP-Seq_LS180_Human	1.35736412
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.34688130
54	STAT3_23295773_ChIP-Seq_U87_Human	1.33447175
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.32400914
56	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.30787959
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.29824040
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29824040
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.28667045
60	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.23886551
61	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.20016794
62	P300_18555785_Chip-Seq_ESCs_Mouse	1.19476534
63	GATA3_26560356_Chip-Seq_TH2_Human	1.15152270
64	GBX2_23144817_ChIP-Seq_PC3_Human	1.14369055
65	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.13770287
66	TCF4_23295773_ChIP-Seq_U87_Human	1.13234682
67	IGF1R_20145208_ChIP-Seq_DFB_Human	1.13172957
68	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.12907707
69	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11435434
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.11119218
71	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.10015599
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09689270
73	ETV1_20927104_ChIP-Seq_GIST48_Human	1.09463352
74	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.09129389
75	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.08454375
76	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07705593
77	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07705593
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07594217
79	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.07593785
80	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.07549478
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.07422795
82	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06753928
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.06529406
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05515090
85	GATA3_27048872_Chip-Seq_THYMUS_Human	1.04525142
86	SMAD4_21799915_ChIP-Seq_A2780_Human	1.04421492
87	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.03740521
88	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.03168357
89	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.02889103
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.02295371
91	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.00574217
92	NFYB_21822215_ChIP-Seq_K562_Human	0.99656105
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99642746
94	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99455412
95	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99361290
96	KDM5A_27292631_Chip-Seq_BREAST_Human	0.99193327
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98991872
98	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.98364160
99	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.97710143
100	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.97608477

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	5.94050548
2	MP0000569_abnormal_digit_pigmentation	5.01644220
3	MP0008058_abnormal_DNA_repair	3.41033919
4	MP0008877_abnormal_DNA_methylation	3.15354493
5	MP0003763_abnormal_thymus_physiology	2.71890013
6	MP0005360_urolithiasis	2.35870540
7	MP0005174_abnormal_tail_pigmentation	2.30124465
8	MP0002396_abnormal_hematopoietic_system	2.29281764
9	MP0010094_abnormal_chromosome_stability	2.07939036
10	MP0001853_heart_inflammation	2.02959965
11	MP0005310_abnormal_salivary_gland	2.00144628
12	MP0001790_abnormal_immune_system	1.96680857
13	MP0005387_immune_system_phenotype	1.96680857
14	MP0003195_calcinosis	1.96487255
15	MP0001800_abnormal_humoral_immune	1.95371839
16	MP0009785_altered_susceptibility_to	1.94717980
17	MP0001501_abnormal_sleep_pattern	1.91762833
18	MP0001835_abnormal_antigen_presentation	1.86604123
19	MP0003950_abnormal_plasma_membrane	1.69707266
20	MP0002405_respiratory_system_inflammati	1.68528062
21	MP0009333_abnormal_splenocyte_physiolog	1.60908270
22	MP0003718_maternal_effect	1.58738830
23	MP0005670_abnormal_white_adipose	1.56611821
24	MP0000015_abnormal_ear_pigmentation	1.55853504
25	MP0001873_stomach_inflammation	1.54954975
26	MP0003077_abnormal_cell_cycle	1.52966860
27	MP0001764_abnormal_homeostasis	1.52864563
28	MP0002148_abnormal_hypersensitivity_rea	1.49593294
29	MP0004147_increased_porphyrin_level	1.49498710
30	MP0006035_abnormal_mitochondrial_morpho	1.46373501
31	MP0006036_abnormal_mitochondrial_physio	1.46337335
32	MP0002723_abnormal_immune_serum	1.38229714
33	MP0002420_abnormal_adaptive_immunity	1.36197327
34	MP0002398_abnormal_bone_marrow	1.36121728
35	MP0002166_altered_tumor_susceptibility	1.33090451
36	MP0001819_abnormal_immune_cell	1.31958219
37	MP0001986_abnormal_taste_sensitivity	1.30582320
38	MP0000703_abnormal_thymus_morphology	1.27102659
39	MP0004808_abnormal_hematopoietic_stem	1.23259991
40	MP0000689_abnormal_spleen_morphology	1.21974426
41	MP0008873_increased_physiological_sensi	1.20007563
42	MP0004957_abnormal_blastocyst_morpholog	1.19643041
43	MP0005075_abnormal_melanosome_morpholog	1.19509040
44	MP0002452_abnormal_antigen_presenting	1.19007747
45	MP0004142_abnormal_muscle_tone	1.17376015
46	MP0000716_abnormal_immune_system	1.16180996
47	MP0003693_abnormal_embryo_hatching	1.15371051
48	MP0000465_gastrointestinal_hemorrhage	1.13344129
49	MP0002736_abnormal_nociception_after	1.13170279
50	MP0004043_abnormal_pH_regulation	1.12617694
51	MP0009697_abnormal_copulation	1.11443545
52	MP0003567_abnormal_fetal_cardiomyocyte	1.09562516
53	MP0003786_premature_aging	1.07481484
54	MP0002722_abnormal_immune_system	1.04090800
55	MP0001929_abnormal_gametogenesis	1.02029312
56	MP0002419_abnormal_innate_immunity	0.99797535
57	MP0001968_abnormal_touch/_nociception	0.99523518
58	MP0002006_tumorigenesis	0.98976656
59	MP0003221_abnormal_cardiomyocyte_apopto	0.98724873
60	MP0002210_abnormal_sex_determination	0.97943803
61	MP0002277_abnormal_respiratory_mucosa	0.97248595
62	MP0000685_abnormal_immune_system	0.96788919
63	MP0009840_abnormal_foam_cell	0.96351561
64	MP0002429_abnormal_blood_cell	0.94880476
65	MP0003111_abnormal_nucleus_morphology	0.94493501
66	MP0003890_abnormal_embryonic-extraembry	0.94027274
67	MP0001485_abnormal_pinna_reflex	0.92690487
68	MP0000371_diluted_coat_color	0.92137731
69	MP0005464_abnormal_platelet_physiology	0.91518622
70	MP0005410_abnormal_fertilization	0.91387523
71	MP0005395_other_phenotype	0.89352866
72	MP0001851_eye_inflammation	0.87986277
73	MP0001915_intracranial_hemorrhage	0.85302623
74	MP0002138_abnormal_hepatobiliary_system	0.85215407
75	MP0005551_abnormal_eye_electrophysiolog	0.84766108
76	MP0005397_hematopoietic_system_phenotyp	0.84050602
77	MP0001545_abnormal_hematopoietic_system	0.84050602
78	MP0000372_irregular_coat_pigmentation	0.83755461
79	MP0001845_abnormal_inflammatory_respons	0.82434410
80	MP0008872_abnormal_physiological_respon	0.81556352
81	MP0005025_abnormal_response_to	0.81001325
82	MP0005671_abnormal_response_to	0.79686171
83	MP0005000_abnormal_immune_tolerance	0.79234815
84	MP0009115_abnormal_fat_cell	0.79163657
85	MP0005266_abnormal_metabolism	0.77191750
86	MP0002019_abnormal_tumor_incidence	0.76733955
87	MP0001145_abnormal_male_reproductive	0.75739937
88	MP0005376_homeostasis/metabolism_phenot	0.75507176
89	MP0002095_abnormal_skin_pigmentation	0.75465065
90	MP0000653_abnormal_sex_gland	0.75419737
91	MP0006082_CNS_inflammation	0.73640584
92	MP0003646_muscle_fatigue	0.72365652
93	MP0002876_abnormal_thyroid_physiology	0.71555989
94	MP0005332_abnormal_amino_acid	0.70238569
95	MP0000358_abnormal_cell_content/	0.69728575
96	MP0003448_altered_tumor_morphology	0.69262494
97	MP0003806_abnormal_nucleotide_metabolis	0.68150463
98	MP0004215_abnormal_myocardial_fiber	0.66606013
99	MP0003866_abnormal_defecation	0.65938485
100	MP0004885_abnormal_endolymph	0.64354821

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	5.04364266
2	Abnormality of the renal collecting system (HP:0004742)	4.30727308
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.87681099
4	Chromsome breakage (HP:0040012)	3.70417712
5	Acute myeloid leukemia (HP:0004808)	3.67610347
6	Acute lymphatic leukemia (HP:0006721)	3.64186507
7	Tubulointerstitial nephritis (HP:0001970)	3.59844151
8	Volvulus (HP:0002580)	3.32716704
9	Broad-based gait (HP:0002136)	3.24549215
10	Pancreatic cysts (HP:0001737)	3.06348394
11	Autoimmune hemolytic anemia (HP:0001890)	3.01055992
12	Clubbing of toes (HP:0100760)	2.96176131
13	Urethral obstruction (HP:0000796)	2.92536277
14	Opisthotonus (HP:0002179)	2.89177869
15	Long foot (HP:0001833)	2.85646362
16	Genetic anticipation (HP:0003743)	2.82695771
17	Reticulocytopenia (HP:0001896)	2.75625697
18	Ureteral duplication (HP:0000073)	2.70438208
19	Facial diplegia (HP:0001349)	2.70421377
20	Ureteral stenosis (HP:0000071)	2.67351249
21	Abnormality of the prostate (HP:0008775)	2.66187996
22	Abnormality of the pons (HP:0007361)	2.64145093
23	Ectopic kidney (HP:0000086)	2.63773919
24	Stomach cancer (HP:0012126)	2.56946151
25	Ureteral obstruction (HP:0006000)	2.54978812
26	Abnormality of DNA repair (HP:0003254)	2.51611414
27	Abnormality of T cell number (HP:0011839)	2.51279333
28	Abnormality of chromosome stability (HP:0003220)	2.51025522
29	Chronic hepatic failure (HP:0100626)	2.46889293
30	Abnormality of the ileum (HP:0001549)	2.45298393
31	Colon cancer (HP:0003003)	2.42573907
32	Eosinophilia (HP:0001880)	2.40868441
33	Hypoplasia of the pons (HP:0012110)	2.40521415
34	IgM deficiency (HP:0002850)	2.38977215
35	Abnormality of the fingertips (HP:0001211)	2.38948487
36	Lipid accumulation in hepatocytes (HP:0006561)	2.36412631
37	Abnormality of pyrimidine metabolism (HP:0004353)	2.36280785
38	Pancreatic fibrosis (HP:0100732)	2.34205047
39	Meckel diverticulum (HP:0002245)	2.30126600
40	True hermaphroditism (HP:0010459)	2.28934097
41	T lymphocytopenia (HP:0005403)	2.28361673
42	Increased hepatocellular lipid droplets (HP:0006565)	2.24583217
43	Abnormality of eosinophils (HP:0001879)	2.23995107
44	Microvesicular hepatic steatosis (HP:0001414)	2.23711099
45	Abnormality of B cell number (HP:0010975)	2.22909674
46	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.21793148
47	Abnormality of the preputium (HP:0100587)	2.20199640
48	Nephronophthisis (HP:0000090)	2.19287319
49	Gaze-evoked nystagmus (HP:0000640)	2.17777765
50	Panhypogammaglobulinemia (HP:0003139)	2.17153702
51	Thrombocytosis (HP:0001894)	2.16625107
52	Absent radius (HP:0003974)	2.16591217
53	B lymphocytopenia (HP:0010976)	2.16223378
54	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.16144297
55	Severe visual impairment (HP:0001141)	2.13710664
56	Dyschromatopsia (HP:0007641)	2.11992106
57	Abnormality of midbrain morphology (HP:0002418)	2.11819108
58	Molar tooth sign on MRI (HP:0002419)	2.11819108
59	Myelodysplasia (HP:0002863)	2.09677341
60	Absent forearm bone (HP:0003953)	2.05096531
61	Aplasia involving forearm bones (HP:0009822)	2.05096531
62	Hypothermia (HP:0002045)	2.04239596
63	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.03026637
64	Chronic diarrhea (HP:0002028)	1.97842675
65	Progressive inability to walk (HP:0002505)	1.97110784
66	Widely spaced teeth (HP:0000687)	1.96552906
67	Abnormality of the renal medulla (HP:0100957)	1.96528124
68	Abnormality of the renal cortex (HP:0011035)	1.96383861
69	Mediastinal lymphadenopathy (HP:0100721)	1.95172195
70	Encephalitis (HP:0002383)	1.94759702
71	Spontaneous abortion (HP:0005268)	1.94031597
72	Mitochondrial inheritance (HP:0001427)	1.93707688
73	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.92557536
74	Abnormality of lateral ventricle (HP:0030047)	1.91800196
75	Renal cortical cysts (HP:0000803)	1.90553305
76	Renal Fanconi syndrome (HP:0001994)	1.88991242
77	Granulocytopenia (HP:0001913)	1.88373175
78	Cupped ear (HP:0000378)	1.88183845
79	Increased intramyocellular lipid droplets (HP:0012240)	1.87354245
80	Submucous cleft hard palate (HP:0000176)	1.85567971
81	Absent/shortened dynein arms (HP:0200106)	1.84833342
82	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.84833342
83	Abnormality of T cells (HP:0002843)	1.84474051
84	Pigmentary retinal degeneration (HP:0001146)	1.83845165
85	Oral leukoplakia (HP:0002745)	1.82870186
86	Optic neuritis (HP:0100653)	1.81299091
87	Retrobulbar optic neuritis (HP:0100654)	1.81299091
88	Febrile seizures (HP:0002373)	1.80476407
89	Progressive cerebellar ataxia (HP:0002073)	1.78469080
90	Increased CSF lactate (HP:0002490)	1.77981776
91	Abnormal mitochondria in muscle tissue (HP:0008316)	1.75624188
92	Increased serum pyruvate (HP:0003542)	1.74294570
93	Duplication of thumb phalanx (HP:0009942)	1.74079126
94	Absent thumb (HP:0009777)	1.73815562
95	Exertional dyspnea (HP:0002875)	1.73786760
96	Abnormality of incisor morphology (HP:0011063)	1.73087678
97	Neutropenia (HP:0001875)	1.71608281
98	Recurrent cutaneous fungal infections (HP:0011370)	1.70310806
99	Chronic mucocutaneous candidiasis (HP:0002728)	1.70310806
100	Abnormality of small intestinal villus morphology (HP:0011472)	1.69439334

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	4.59857726
2	TRIM28	3.35553202
3	MAP4K2	3.01558774
4	TXK	2.96506129
5	PIK3CG	2.88986618
6	NUAK1	2.87479127
7	PBK	2.43656433
8	ZAK	2.43387367
9	MAP3K6	2.41426190
10	MKNK2	2.39547968
11	FRK	2.39165954
12	BMPR1B	2.25367501
13	SRPK1	2.12125692
14	EIF2AK3	2.05087341
15	MST4	2.02996271
16	ACVR1B	2.01818698
17	TSSK6	1.99138150
18	WNK3	1.84906266
19	STK16	1.77534655
20	MAP3K12	1.70791374
21	NEK9	1.63499774
22	WNK1	1.62394971
23	RAF1	1.57430891
24	PDK2	1.57083908
25	CDK8	1.52944032
26	MAP3K13	1.52595846
27	TAF1	1.49196164
28	CDK12	1.42370920
29	TAOK3	1.40144916
30	AKT3	1.39295479
31	SIK3	1.35878885
32	PLK4	1.26655179
33	TEC	1.23150646
34	TYK2	1.22507270
35	VRK1	1.21071954
36	TNK2	1.13730855
37	MKNK1	1.12604432
38	NEK2	1.09949670
39	WNK4	1.04600604
40	TLK1	1.04525702
41	MAP3K5	1.03588685
42	MAP2K6	0.98706990
43	BUB1	0.96632097
44	CAMK1D	0.93241279
45	EIF2AK1	0.91668952
46	BCR	0.87445169
47	MAPK13	0.84702595
48	TNIK	0.83947977
49	BRD4	0.83432770
50	NLK	0.82816584
51	NEK6	0.81438915
52	PLK2	0.80824364
53	VRK2	0.80096879
54	ATR	0.78039568
55	MAP3K4	0.70480835
56	BCKDK	0.69826242
57	CAMK1G	0.66648466
58	OXSR1	0.60771483
59	RPS6KA5	0.59274518
60	RPS6KA4	0.59032392
61	CDK3	0.58132963
62	PIK3CA	0.57542157
63	MAP2K7	0.57213992
64	TGFBR1	0.56696886
65	IKBKE	0.56026782
66	STK4	0.55123685
67	PRKCQ	0.53601507
68	STK39	0.51699612
69	DMPK	0.51619926
70	INSRR	0.50599294
71	MELK	0.50415155
72	ATM	0.49768151
73	BLK	0.49392930
74	CHEK1	0.49373479
75	BTK	0.48594304
76	SGK2	0.48248245
77	NME1	0.48247035
78	CLK1	0.48232066
79	MAP2K3	0.45837272
80	ILK	0.44634472
81	IKBKB	0.44139131
82	MAP3K9	0.43652054
83	ADRBK2	0.41190242
84	KSR1	0.41074024
85	ITK	0.40801141
86	CAMK4	0.40042694
87	CDK4	0.39457922
88	MAP3K10	0.37688999
89	PRKG1	0.37323332
90	LCK	0.37182774
91	PLK3	0.37024956
92	KIT	0.35897186
93	MAP2K4	0.35537122
94	CSNK1A1	0.31801171
95	PIM1	0.30140254
96	CSNK2A2	0.28693680
97	MAPK10	0.27461495
98	SGK1	0.25593129
99	PTK2B	0.25468616
100	ROCK2	0.25428377

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.94605246
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.90268072
3	RNA polymerase_Homo sapiens_hsa03020	3.41578377
4	Homologous recombination_Homo sapiens_hsa03440	3.30553879
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.91496050
6	Basal transcription factors_Homo sapiens_hsa03022	2.90853258
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.76954890
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.47511334
9	Mismatch repair_Homo sapiens_hsa03430	2.25299805
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.23332740
11	Nucleotide excision repair_Homo sapiens_hsa03420	1.95942036
12	Propanoate metabolism_Homo sapiens_hsa00640	1.95191386
13	Graft-versus-host disease_Homo sapiens_hsa05332	1.94725206
14	RNA transport_Homo sapiens_hsa03013	1.76947499
15	Spliceosome_Homo sapiens_hsa03040	1.71745930
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.66796747
17	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.64807835
18	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.63902551
19	Circadian rhythm_Homo sapiens_hsa04710	1.63206486
20	Allograft rejection_Homo sapiens_hsa05330	1.60761264
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.57813273
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.54527493
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.51973044
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.50067863
25	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.49053498
26	Lysine degradation_Homo sapiens_hsa00310	1.48692788
27	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.47041334
28	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.37658289
29	DNA replication_Homo sapiens_hsa03030	1.36985116
30	RNA degradation_Homo sapiens_hsa03018	1.26171642
31	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.19960701
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.18507797
33	Protein export_Homo sapiens_hsa03060	1.18335274
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.16294890
35	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.15363896
36	Purine metabolism_Homo sapiens_hsa00230	1.07199292
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.06466293
38	TNF signaling pathway_Homo sapiens_hsa04668	1.05027488
39	mRNA surveillance pathway_Homo sapiens_hsa03015	1.04598948
40	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.04309293
41	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.98466627
42	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.97930115
43	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.97159847
44	Legionellosis_Homo sapiens_hsa05134	0.94775744
45	Measles_Homo sapiens_hsa05162	0.92048318
46	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.83911023
47	Sulfur metabolism_Homo sapiens_hsa00920	0.80693189
48	African trypanosomiasis_Homo sapiens_hsa05143	0.79965483
49	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.79371815
50	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.77994292
51	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.77690690
52	Base excision repair_Homo sapiens_hsa03410	0.76840247
53	Huntingtons disease_Homo sapiens_hsa05016	0.74029927
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.73568349
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.72761645
56	Hepatitis B_Homo sapiens_hsa05161	0.69097959
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.68301603
58	Parkinsons disease_Homo sapiens_hsa05012	0.68282677
59	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.67708327
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.64180216
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62178041
62	Asthma_Homo sapiens_hsa05310	0.61584137
63	Cell cycle_Homo sapiens_hsa04110	0.56773358
64	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.55703960
65	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55598655
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.55346330
67	Herpes simplex infection_Homo sapiens_hsa05168	0.55319066
68	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54605281
69	Apoptosis_Homo sapiens_hsa04210	0.51416116
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50774566
71	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.49388452
72	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.48473173
73	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.48062042
74	Renin-angiotensin system_Homo sapiens_hsa04614	0.44303181
75	Ribosome_Homo sapiens_hsa03010	0.43501601
76	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.43498573
77	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.42840560
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42297021
79	Acute myeloid leukemia_Homo sapiens_hsa05221	0.41230005
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.37132974
81	FoxO signaling pathway_Homo sapiens_hsa04068	0.36154641
82	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.35265725
83	Antigen processing and presentation_Homo sapiens_hsa04612	0.33629803
84	Oxidative phosphorylation_Homo sapiens_hsa00190	0.32855076
85	Platelet activation_Homo sapiens_hsa04611	0.32377616
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31024794
87	HTLV-I infection_Homo sapiens_hsa05166	0.28914522
88	Influenza A_Homo sapiens_hsa05164	0.28170564
89	Phototransduction_Homo sapiens_hsa04744	0.27782454
90	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.27781170
91	Oocyte meiosis_Homo sapiens_hsa04114	0.26771817
92	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.25955672
93	Retinol metabolism_Homo sapiens_hsa00830	0.23962800
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.23437241
95	Regulation of autophagy_Homo sapiens_hsa04140	0.22794857
96	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.22644445
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.22092692
98	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.21741809
99	Osteoclast differentiation_Homo sapiens_hsa04380	0.20690393
100	ABC transporters_Homo sapiens_hsa02010	0.19196029

HNRNPA1P68

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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