HNRNPA1P68

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)6.23301451
2piRNA metabolic process (GO:0034587)5.16815754
3synapsis (GO:0007129)4.72745539
4rRNA modification (GO:0000154)4.47384665
5rRNA methylation (GO:0031167)4.38717603
6histone H3-K4 trimethylation (GO:0080182)4.05290262
7pseudouridine synthesis (GO:0001522)4.04424197
8regulation of meiosis I (GO:0060631)4.04121004
9male meiosis I (GO:0007141)3.97521380
10regulation of immunoglobulin secretion (GO:0051023)3.90034566
11tryptophan metabolic process (GO:0006568)3.88281625
12histone H3-K4 methylation (GO:0051568)3.78465744
13regulation of regulatory T cell differentiation (GO:0045589)3.71985150
14regulation of translational termination (GO:0006449)3.71575964
15positive regulation of DNA recombination (GO:0045911)3.69895253
16positive regulation of developmental pigmentation (GO:0048087)3.67734250
17meiosis I (GO:0007127)3.61597266
18regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.55415577
19positive regulation of B cell mediated immunity (GO:0002714)3.49927806
20positive regulation of immunoglobulin mediated immune response (GO:0002891)3.49927806
21chromosome organization involved in meiosis (GO:0070192)3.42415555
22modulation of growth of symbiont involved in interaction with host (GO:0044144)3.40141130
23regulation of growth of symbiont in host (GO:0044126)3.40141130
24negative regulation of growth of symbiont in host (GO:0044130)3.40141130
25negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.40141130
26positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.40138204
27maturation of SSU-rRNA (GO:0030490)3.37763499
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.34865683
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.34865683
30regulation of translation, ncRNA-mediated (GO:0045974)3.34865683
31indolalkylamine metabolic process (GO:0006586)3.34104453
32DNA synthesis involved in DNA repair (GO:0000731)3.31353579
33peptidyl-lysine trimethylation (GO:0018023)3.29140397
34cell wall macromolecule catabolic process (GO:0016998)3.27456350
35negative T cell selection (GO:0043383)3.25395589
36neutrophil mediated immunity (GO:0002446)3.24433888
37reciprocal meiotic recombination (GO:0007131)3.21870659
38reciprocal DNA recombination (GO:0035825)3.21870659
39protein prenylation (GO:0018342)3.19465061
40prenylation (GO:0097354)3.19465061
41regulation of MHC class II biosynthetic process (GO:0045346)3.17112338
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.16380442
43male meiosis (GO:0007140)3.14721309
44regulation of cilium movement (GO:0003352)3.11895480
45negative regulation of T cell mediated immunity (GO:0002710)3.09683619
46histone H2A acetylation (GO:0043968)3.09609993
47DNA methylation involved in gamete generation (GO:0043046)3.08155919
48regulation of chronic inflammatory response (GO:0002676)3.07710607
49snRNA transcription (GO:0009301)3.04010722
50positive regulation of granulocyte differentiation (GO:0030854)3.03482834
51fucose catabolic process (GO:0019317)3.03447056
52L-fucose metabolic process (GO:0042354)3.03447056
53L-fucose catabolic process (GO:0042355)3.03447056
54meiotic nuclear division (GO:0007126)3.00724040
55positive T cell selection (GO:0043368)2.99720509
56positive regulation of alpha-beta T cell proliferation (GO:0046641)2.97413251
57positive regulation of T cell cytokine production (GO:0002726)2.95642104
58signal peptide processing (GO:0006465)2.93921402
59gene silencing by RNA (GO:0031047)2.90709362
60positive regulation of isotype switching (GO:0045830)2.85854324
61histone H3-K36 demethylation (GO:0070544)2.85311268
62cellular extravasation (GO:0045123)2.83816921
63regulation of pigment cell differentiation (GO:0050932)2.82267270
64double-strand break repair via homologous recombination (GO:0000724)2.81274298
65superoxide anion generation (GO:0042554)2.81152620
66embryonic hemopoiesis (GO:0035162)2.81080395
67cell wall macromolecule metabolic process (GO:0044036)2.80488645
68recombinational repair (GO:0000725)2.79105775
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.78813402
70otic vesicle formation (GO:0030916)2.78430342
71regulation of B cell mediated immunity (GO:0002712)2.78144940
72regulation of MHC class I biosynthetic process (GO:0045343)2.78119572
73CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.76196780
74cytokine biosynthetic process (GO:0042089)2.75534318
75muscle organ morphogenesis (GO:0048644)2.73948517
76positive regulation of immunoglobulin production (GO:0002639)2.73834866
77transcription elongation from RNA polymerase I promoter (GO:0006362)2.72032892
78attachment of spindle microtubules to kinetochore (GO:0008608)2.71799298
79regulation of immunoglobulin mediated immune response (GO:0002889)2.71360270
80DNA deamination (GO:0045006)2.70019249
81positive regulation of humoral immune response (GO:0002922)2.69886839
82mitochondrial respiratory chain complex assembly (GO:0033108)2.66439809
83hepatocyte apoptotic process (GO:0097284)2.65440603
84protein complex biogenesis (GO:0070271)2.61767763
85respiratory chain complex IV assembly (GO:0008535)2.61594745
86meiotic cell cycle process (GO:1903046)2.60389847
87regulation of isotype switching to IgG isotypes (GO:0048302)2.58432778
88polyol catabolic process (GO:0046174)2.58020400
89synaptonemal complex organization (GO:0070193)2.56862257
90regulation of interleukin-8 biosynthetic process (GO:0045414)2.56666294
91tachykinin receptor signaling pathway (GO:0007217)2.56532503
92peptidyl-lysine methylation (GO:0018022)2.56459538
93positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.56059146
94positive regulation of T cell chemotaxis (GO:0010820)2.55240659
95regulation of T cell chemotaxis (GO:0010819)2.55240659
96activated T cell proliferation (GO:0050798)2.52891296
97synaptonemal complex assembly (GO:0007130)2.52009433
98myeloid leukocyte mediated immunity (GO:0002444)2.51303322
99positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.48817261
100regulation of interleukin-12 biosynthetic process (GO:0045075)2.48683551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EST1_17652178_ChIP-ChIP_JURKAT_Human2.75713519
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68931353
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.59264416
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.58311658
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51712648
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42111795
7ZNF274_21170338_ChIP-Seq_K562_Hela2.40214294
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30614759
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.25901253
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.24293411
11E2F7_22180533_ChIP-Seq_HELA_Human2.22474750
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19779373
13VDR_23849224_ChIP-Seq_CD4+_Human2.18853971
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17978743
15ELK1_19687146_ChIP-ChIP_HELA_Human2.09659906
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09197986
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.08122280
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.02740380
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99566448
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.97121875
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95393107
22EWS_26573619_Chip-Seq_HEK293_Human1.95165158
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88489821
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85918660
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.84083570
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81843984
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80654088
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80524750
29TP53_16413492_ChIP-PET_HCT116_Human1.80452449
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74957918
31FOXP3_21729870_ChIP-Seq_TREG_Human1.74030432
32ER_23166858_ChIP-Seq_MCF-7_Human1.72428260
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71628236
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69710604
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68033990
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.64043905
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63843473
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56567083
39MYB_26560356_Chip-Seq_TH2_Human1.56538463
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55997676
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.53730277
42TAF15_26573619_Chip-Seq_HEK293_Human1.53269920
43GATA1_22025678_ChIP-Seq_K562_Human1.51544288
44FUS_26573619_Chip-Seq_HEK293_Human1.51388638
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.51280451
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46442409
47P300_19829295_ChIP-Seq_ESCs_Human1.46057233
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42303331
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39558658
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.39399837
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39124904
52VDR_22108803_ChIP-Seq_LS180_Human1.35736412
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34688130
54STAT3_23295773_ChIP-Seq_U87_Human1.33447175
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32400914
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30787959
57CBP_20019798_ChIP-Seq_JUKART_Human1.29824040
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29824040
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28667045
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.23886551
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20016794
62P300_18555785_Chip-Seq_ESCs_Mouse1.19476534
63GATA3_26560356_Chip-Seq_TH2_Human1.15152270
64GBX2_23144817_ChIP-Seq_PC3_Human1.14369055
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.13770287
66TCF4_23295773_ChIP-Seq_U87_Human1.13234682
67IGF1R_20145208_ChIP-Seq_DFB_Human1.13172957
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12907707
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.11435434
70TP53_22573176_ChIP-Seq_HFKS_Human1.11119218
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.10015599
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.09689270
73ETV1_20927104_ChIP-Seq_GIST48_Human1.09463352
74OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09129389
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.08454375
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07705593
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07705593
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07594217
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07593785
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07549478
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.07422795
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06753928
83TCF4_22108803_ChIP-Seq_LS180_Human1.06529406
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.05515090
85GATA3_27048872_Chip-Seq_THYMUS_Human1.04525142
86SMAD4_21799915_ChIP-Seq_A2780_Human1.04421492
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03740521
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03168357
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02889103
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02295371
91OCT4_18555785_Chip-Seq_ESCs_Mouse1.00574217
92NFYB_21822215_ChIP-Seq_K562_Human0.99656105
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99642746
94FLI1_21867929_ChIP-Seq_TH2_Mouse0.99455412
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99361290
96KDM5A_27292631_Chip-Seq_BREAST_Human0.99193327
97P53_22387025_ChIP-Seq_ESCs_Mouse0.98991872
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98364160
99SOX2_18555785_Chip-Seq_ESCs_Mouse0.97710143
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97608477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.94050548
2MP0000569_abnormal_digit_pigmentation5.01644220
3MP0008058_abnormal_DNA_repair3.41033919
4MP0008877_abnormal_DNA_methylation3.15354493
5MP0003763_abnormal_thymus_physiology2.71890013
6MP0005360_urolithiasis2.35870540
7MP0005174_abnormal_tail_pigmentation2.30124465
8MP0002396_abnormal_hematopoietic_system2.29281764
9MP0010094_abnormal_chromosome_stability2.07939036
10MP0001853_heart_inflammation2.02959965
11MP0005310_abnormal_salivary_gland2.00144628
12MP0001790_abnormal_immune_system1.96680857
13MP0005387_immune_system_phenotype1.96680857
14MP0003195_calcinosis1.96487255
15MP0001800_abnormal_humoral_immune1.95371839
16MP0009785_altered_susceptibility_to1.94717980
17MP0001501_abnormal_sleep_pattern1.91762833
18MP0001835_abnormal_antigen_presentation1.86604123
19MP0003950_abnormal_plasma_membrane1.69707266
20MP0002405_respiratory_system_inflammati1.68528062
21MP0009333_abnormal_splenocyte_physiolog1.60908270
22MP0003718_maternal_effect1.58738830
23MP0005670_abnormal_white_adipose1.56611821
24MP0000015_abnormal_ear_pigmentation1.55853504
25MP0001873_stomach_inflammation1.54954975
26MP0003077_abnormal_cell_cycle1.52966860
27MP0001764_abnormal_homeostasis1.52864563
28MP0002148_abnormal_hypersensitivity_rea1.49593294
29MP0004147_increased_porphyrin_level1.49498710
30MP0006035_abnormal_mitochondrial_morpho1.46373501
31MP0006036_abnormal_mitochondrial_physio1.46337335
32MP0002723_abnormal_immune_serum1.38229714
33MP0002420_abnormal_adaptive_immunity1.36197327
34MP0002398_abnormal_bone_marrow1.36121728
35MP0002166_altered_tumor_susceptibility1.33090451
36MP0001819_abnormal_immune_cell1.31958219
37MP0001986_abnormal_taste_sensitivity1.30582320
38MP0000703_abnormal_thymus_morphology1.27102659
39MP0004808_abnormal_hematopoietic_stem1.23259991
40MP0000689_abnormal_spleen_morphology1.21974426
41MP0008873_increased_physiological_sensi1.20007563
42MP0004957_abnormal_blastocyst_morpholog1.19643041
43MP0005075_abnormal_melanosome_morpholog1.19509040
44MP0002452_abnormal_antigen_presenting1.19007747
45MP0004142_abnormal_muscle_tone1.17376015
46MP0000716_abnormal_immune_system1.16180996
47MP0003693_abnormal_embryo_hatching1.15371051
48MP0000465_gastrointestinal_hemorrhage1.13344129
49MP0002736_abnormal_nociception_after1.13170279
50MP0004043_abnormal_pH_regulation1.12617694
51MP0009697_abnormal_copulation1.11443545
52MP0003567_abnormal_fetal_cardiomyocyte1.09562516
53MP0003786_premature_aging1.07481484
54MP0002722_abnormal_immune_system1.04090800
55MP0001929_abnormal_gametogenesis1.02029312
56MP0002419_abnormal_innate_immunity0.99797535
57MP0001968_abnormal_touch/_nociception0.99523518
58MP0002006_tumorigenesis0.98976656
59MP0003221_abnormal_cardiomyocyte_apopto0.98724873
60MP0002210_abnormal_sex_determination0.97943803
61MP0002277_abnormal_respiratory_mucosa0.97248595
62MP0000685_abnormal_immune_system0.96788919
63MP0009840_abnormal_foam_cell0.96351561
64MP0002429_abnormal_blood_cell0.94880476
65MP0003111_abnormal_nucleus_morphology0.94493501
66MP0003890_abnormal_embryonic-extraembry0.94027274
67MP0001485_abnormal_pinna_reflex0.92690487
68MP0000371_diluted_coat_color0.92137731
69MP0005464_abnormal_platelet_physiology0.91518622
70MP0005410_abnormal_fertilization0.91387523
71MP0005395_other_phenotype0.89352866
72MP0001851_eye_inflammation0.87986277
73MP0001915_intracranial_hemorrhage0.85302623
74MP0002138_abnormal_hepatobiliary_system0.85215407
75MP0005551_abnormal_eye_electrophysiolog0.84766108
76MP0005397_hematopoietic_system_phenotyp0.84050602
77MP0001545_abnormal_hematopoietic_system0.84050602
78MP0000372_irregular_coat_pigmentation0.83755461
79MP0001845_abnormal_inflammatory_respons0.82434410
80MP0008872_abnormal_physiological_respon0.81556352
81MP0005025_abnormal_response_to0.81001325
82MP0005671_abnormal_response_to0.79686171
83MP0005000_abnormal_immune_tolerance0.79234815
84MP0009115_abnormal_fat_cell0.79163657
85MP0005266_abnormal_metabolism0.77191750
86MP0002019_abnormal_tumor_incidence0.76733955
87MP0001145_abnormal_male_reproductive0.75739937
88MP0005376_homeostasis/metabolism_phenot0.75507176
89MP0002095_abnormal_skin_pigmentation0.75465065
90MP0000653_abnormal_sex_gland0.75419737
91MP0006082_CNS_inflammation0.73640584
92MP0003646_muscle_fatigue0.72365652
93MP0002876_abnormal_thyroid_physiology0.71555989
94MP0005332_abnormal_amino_acid0.70238569
95MP0000358_abnormal_cell_content/0.69728575
96MP0003448_altered_tumor_morphology0.69262494
97MP0003806_abnormal_nucleotide_metabolis0.68150463
98MP0004215_abnormal_myocardial_fiber0.66606013
99MP0003866_abnormal_defecation0.65938485
100MP0004885_abnormal_endolymph0.64354821

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)5.04364266
2Abnormality of the renal collecting system (HP:0004742)4.30727308
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.87681099
4Chromsome breakage (HP:0040012)3.70417712
5Acute myeloid leukemia (HP:0004808)3.67610347
6Acute lymphatic leukemia (HP:0006721)3.64186507
7Tubulointerstitial nephritis (HP:0001970)3.59844151
8Volvulus (HP:0002580)3.32716704
9Broad-based gait (HP:0002136)3.24549215
10Pancreatic cysts (HP:0001737)3.06348394
11Autoimmune hemolytic anemia (HP:0001890)3.01055992
12Clubbing of toes (HP:0100760)2.96176131
13Urethral obstruction (HP:0000796)2.92536277
14Opisthotonus (HP:0002179)2.89177869
15Long foot (HP:0001833)2.85646362
16Genetic anticipation (HP:0003743)2.82695771
17Reticulocytopenia (HP:0001896)2.75625697
18Ureteral duplication (HP:0000073)2.70438208
19Facial diplegia (HP:0001349)2.70421377
20Ureteral stenosis (HP:0000071)2.67351249
21Abnormality of the prostate (HP:0008775)2.66187996
22Abnormality of the pons (HP:0007361)2.64145093
23Ectopic kidney (HP:0000086)2.63773919
24Stomach cancer (HP:0012126)2.56946151
25Ureteral obstruction (HP:0006000)2.54978812
26Abnormality of DNA repair (HP:0003254)2.51611414
27Abnormality of T cell number (HP:0011839)2.51279333
28Abnormality of chromosome stability (HP:0003220)2.51025522
29Chronic hepatic failure (HP:0100626)2.46889293
30Abnormality of the ileum (HP:0001549)2.45298393
31Colon cancer (HP:0003003)2.42573907
32Eosinophilia (HP:0001880)2.40868441
33Hypoplasia of the pons (HP:0012110)2.40521415
34IgM deficiency (HP:0002850)2.38977215
35Abnormality of the fingertips (HP:0001211)2.38948487
36Lipid accumulation in hepatocytes (HP:0006561)2.36412631
37Abnormality of pyrimidine metabolism (HP:0004353)2.36280785
38Pancreatic fibrosis (HP:0100732)2.34205047
39Meckel diverticulum (HP:0002245)2.30126600
40True hermaphroditism (HP:0010459)2.28934097
41T lymphocytopenia (HP:0005403)2.28361673
42Increased hepatocellular lipid droplets (HP:0006565)2.24583217
43Abnormality of eosinophils (HP:0001879)2.23995107
44Microvesicular hepatic steatosis (HP:0001414)2.23711099
45Abnormality of B cell number (HP:0010975)2.22909674
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21793148
47Abnormality of the preputium (HP:0100587)2.20199640
48Nephronophthisis (HP:0000090)2.19287319
49Gaze-evoked nystagmus (HP:0000640)2.17777765
50Panhypogammaglobulinemia (HP:0003139)2.17153702
51Thrombocytosis (HP:0001894)2.16625107
52Absent radius (HP:0003974)2.16591217
53B lymphocytopenia (HP:0010976)2.16223378
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16144297
55Severe visual impairment (HP:0001141)2.13710664
56Dyschromatopsia (HP:0007641)2.11992106
57Abnormality of midbrain morphology (HP:0002418)2.11819108
58Molar tooth sign on MRI (HP:0002419)2.11819108
59Myelodysplasia (HP:0002863)2.09677341
60Absent forearm bone (HP:0003953)2.05096531
61Aplasia involving forearm bones (HP:0009822)2.05096531
62Hypothermia (HP:0002045)2.04239596
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.03026637
64Chronic diarrhea (HP:0002028)1.97842675
65Progressive inability to walk (HP:0002505)1.97110784
66Widely spaced teeth (HP:0000687)1.96552906
67Abnormality of the renal medulla (HP:0100957)1.96528124
68Abnormality of the renal cortex (HP:0011035)1.96383861
69Mediastinal lymphadenopathy (HP:0100721)1.95172195
70Encephalitis (HP:0002383)1.94759702
71Spontaneous abortion (HP:0005268)1.94031597
72Mitochondrial inheritance (HP:0001427)1.93707688
73Abnormal delayed hypersensitivity skin test (HP:0002963)1.92557536
74Abnormality of lateral ventricle (HP:0030047)1.91800196
75Renal cortical cysts (HP:0000803)1.90553305
76Renal Fanconi syndrome (HP:0001994)1.88991242
77Granulocytopenia (HP:0001913)1.88373175
78Cupped ear (HP:0000378)1.88183845
79Increased intramyocellular lipid droplets (HP:0012240)1.87354245
80Submucous cleft hard palate (HP:0000176)1.85567971
81Absent/shortened dynein arms (HP:0200106)1.84833342
82Dynein arm defect of respiratory motile cilia (HP:0012255)1.84833342
83Abnormality of T cells (HP:0002843)1.84474051
84Pigmentary retinal degeneration (HP:0001146)1.83845165
85Oral leukoplakia (HP:0002745)1.82870186
86Optic neuritis (HP:0100653)1.81299091
87Retrobulbar optic neuritis (HP:0100654)1.81299091
88Febrile seizures (HP:0002373)1.80476407
89Progressive cerebellar ataxia (HP:0002073)1.78469080
90Increased CSF lactate (HP:0002490)1.77981776
91Abnormal mitochondria in muscle tissue (HP:0008316)1.75624188
92Increased serum pyruvate (HP:0003542)1.74294570
93Duplication of thumb phalanx (HP:0009942)1.74079126
94Absent thumb (HP:0009777)1.73815562
95Exertional dyspnea (HP:0002875)1.73786760
96Abnormality of incisor morphology (HP:0011063)1.73087678
97Neutropenia (HP:0001875)1.71608281
98Recurrent cutaneous fungal infections (HP:0011370)1.70310806
99Chronic mucocutaneous candidiasis (HP:0002728)1.70310806
100Abnormality of small intestinal villus morphology (HP:0011472)1.69439334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.59857726
2TRIM283.35553202
3MAP4K23.01558774
4TXK2.96506129
5PIK3CG2.88986618
6NUAK12.87479127
7PBK2.43656433
8ZAK2.43387367
9MAP3K62.41426190
10MKNK22.39547968
11FRK2.39165954
12BMPR1B2.25367501
13SRPK12.12125692
14EIF2AK32.05087341
15MST42.02996271
16ACVR1B2.01818698
17TSSK61.99138150
18WNK31.84906266
19STK161.77534655
20MAP3K121.70791374
21NEK91.63499774
22WNK11.62394971
23RAF11.57430891
24PDK21.57083908
25CDK81.52944032
26MAP3K131.52595846
27TAF11.49196164
28CDK121.42370920
29TAOK31.40144916
30AKT31.39295479
31SIK31.35878885
32PLK41.26655179
33TEC1.23150646
34TYK21.22507270
35VRK11.21071954
36TNK21.13730855
37MKNK11.12604432
38NEK21.09949670
39WNK41.04600604
40TLK11.04525702
41MAP3K51.03588685
42MAP2K60.98706990
43BUB10.96632097
44CAMK1D0.93241279
45EIF2AK10.91668952
46BCR0.87445169
47MAPK130.84702595
48TNIK0.83947977
49BRD40.83432770
50NLK0.82816584
51NEK60.81438915
52PLK20.80824364
53VRK20.80096879
54ATR0.78039568
55MAP3K40.70480835
56BCKDK0.69826242
57CAMK1G0.66648466
58OXSR10.60771483
59RPS6KA50.59274518
60RPS6KA40.59032392
61CDK30.58132963
62PIK3CA0.57542157
63MAP2K70.57213992
64TGFBR10.56696886
65IKBKE0.56026782
66STK40.55123685
67PRKCQ0.53601507
68STK390.51699612
69DMPK0.51619926
70INSRR0.50599294
71MELK0.50415155
72ATM0.49768151
73BLK0.49392930
74CHEK10.49373479
75BTK0.48594304
76SGK20.48248245
77NME10.48247035
78CLK10.48232066
79MAP2K30.45837272
80ILK0.44634472
81IKBKB0.44139131
82MAP3K90.43652054
83ADRBK20.41190242
84KSR10.41074024
85ITK0.40801141
86CAMK40.40042694
87CDK40.39457922
88MAP3K100.37688999
89PRKG10.37323332
90LCK0.37182774
91PLK30.37024956
92KIT0.35897186
93MAP2K40.35537122
94CSNK1A10.31801171
95PIM10.30140254
96CSNK2A20.28693680
97MAPK100.27461495
98SGK10.25593129
99PTK2B0.25468616
100ROCK20.25428377

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.94605246
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.90268072
3RNA polymerase_Homo sapiens_hsa030203.41578377
4Homologous recombination_Homo sapiens_hsa034403.30553879
5Nitrogen metabolism_Homo sapiens_hsa009102.91496050
6Basal transcription factors_Homo sapiens_hsa030222.90853258
7Non-homologous end-joining_Homo sapiens_hsa034502.76954890
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47511334
9Mismatch repair_Homo sapiens_hsa034302.25299805
10Fanconi anemia pathway_Homo sapiens_hsa034602.23332740
11Nucleotide excision repair_Homo sapiens_hsa034201.95942036
12Propanoate metabolism_Homo sapiens_hsa006401.95191386
13Graft-versus-host disease_Homo sapiens_hsa053321.94725206
14RNA transport_Homo sapiens_hsa030131.76947499
15Spliceosome_Homo sapiens_hsa030401.71745930
16Autoimmune thyroid disease_Homo sapiens_hsa053201.66796747
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64807835
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63902551
19Circadian rhythm_Homo sapiens_hsa047101.63206486
20Allograft rejection_Homo sapiens_hsa053301.60761264
21Pyrimidine metabolism_Homo sapiens_hsa002401.57813273
22Type I diabetes mellitus_Homo sapiens_hsa049401.54527493
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51973044
24Primary immunodeficiency_Homo sapiens_hsa053401.50067863
25Dorso-ventral axis formation_Homo sapiens_hsa043201.49053498
26Lysine degradation_Homo sapiens_hsa003101.48692788
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.47041334
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.37658289
29DNA replication_Homo sapiens_hsa030301.36985116
30RNA degradation_Homo sapiens_hsa030181.26171642
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19960701
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18507797
33Protein export_Homo sapiens_hsa030601.18335274
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16294890
35T cell receptor signaling pathway_Homo sapiens_hsa046601.15363896
36Purine metabolism_Homo sapiens_hsa002301.07199292
37Tryptophan metabolism_Homo sapiens_hsa003801.06466293
38TNF signaling pathway_Homo sapiens_hsa046681.05027488
39mRNA surveillance pathway_Homo sapiens_hsa030151.04598948
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04309293
41Epstein-Barr virus infection_Homo sapiens_hsa051690.98466627
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97930115
43Vitamin digestion and absorption_Homo sapiens_hsa049770.97159847
44Legionellosis_Homo sapiens_hsa051340.94775744
45Measles_Homo sapiens_hsa051620.92048318
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.83911023
47Sulfur metabolism_Homo sapiens_hsa009200.80693189
48African trypanosomiasis_Homo sapiens_hsa051430.79965483
49Systemic lupus erythematosus_Homo sapiens_hsa053220.79371815
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77994292
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.77690690
52Base excision repair_Homo sapiens_hsa034100.76840247
53Huntingtons disease_Homo sapiens_hsa050160.74029927
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73568349
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72761645
56Hepatitis B_Homo sapiens_hsa051610.69097959
57Selenocompound metabolism_Homo sapiens_hsa004500.68301603
58Parkinsons disease_Homo sapiens_hsa050120.68282677
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67708327
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64180216
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62178041
62Asthma_Homo sapiens_hsa053100.61584137
63Cell cycle_Homo sapiens_hsa041100.56773358
64Hematopoietic cell lineage_Homo sapiens_hsa046400.55703960
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.55598655
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55346330
67Herpes simplex infection_Homo sapiens_hsa051680.55319066
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54605281
69Apoptosis_Homo sapiens_hsa042100.51416116
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.50774566
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49388452
72TGF-beta signaling pathway_Homo sapiens_hsa043500.48473173
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48062042
74Renin-angiotensin system_Homo sapiens_hsa046140.44303181
75Ribosome_Homo sapiens_hsa030100.43501601
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43498573
77HIF-1 signaling pathway_Homo sapiens_hsa040660.42840560
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42297021
79Acute myeloid leukemia_Homo sapiens_hsa052210.41230005
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.37132974
81FoxO signaling pathway_Homo sapiens_hsa040680.36154641
82B cell receptor signaling pathway_Homo sapiens_hsa046620.35265725
83Antigen processing and presentation_Homo sapiens_hsa046120.33629803
84Oxidative phosphorylation_Homo sapiens_hsa001900.32855076
85Platelet activation_Homo sapiens_hsa046110.32377616
86Glycerolipid metabolism_Homo sapiens_hsa005610.31024794
87HTLV-I infection_Homo sapiens_hsa051660.28914522
88Influenza A_Homo sapiens_hsa051640.28170564
89Phototransduction_Homo sapiens_hsa047440.27782454
90Vitamin B6 metabolism_Homo sapiens_hsa007500.27781170
91Oocyte meiosis_Homo sapiens_hsa041140.26771817
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25955672
93Retinol metabolism_Homo sapiens_hsa008300.23962800
94beta-Alanine metabolism_Homo sapiens_hsa004100.23437241
95Regulation of autophagy_Homo sapiens_hsa041400.22794857
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22644445
97Pyruvate metabolism_Homo sapiens_hsa006200.22092692
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21741809
99Osteoclast differentiation_Homo sapiens_hsa043800.20690393
100ABC transporters_Homo sapiens_hsa020100.19196029

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