ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	5.13125517
2	fucose catabolic process (GO:0019317)	4.54690477
3	L-fucose metabolic process (GO:0042354)	4.54690477
4	L-fucose catabolic process (GO:0042355)	4.54690477
5	response to pheromone (GO:0019236)	4.16827619
6	peptidyl-histidine modification (GO:0018202)	4.13781177
7	DNA deamination (GO:0045006)	3.90573290
8	proteasome assembly (GO:0043248)	3.83784554
9	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.72316712
10	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.72316712
11	replication fork processing (GO:0031297)	3.68708578
12	DNA catabolic process, exonucleolytic (GO:0000738)	3.67107799
13	chromatin remodeling at centromere (GO:0031055)	3.66773531
14	kinetochore organization (GO:0051383)	3.60536425
15	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.59378771
16	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.58282163
17	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.58282163
18	meiotic chromosome segregation (GO:0045132)	3.53940753
19	regulation of helicase activity (GO:0051095)	3.48579867
20	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.48119186
21	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.47384304
22	resolution of meiotic recombination intermediates (GO:0000712)	3.46798947
23	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.45993524
24	CENP-A containing nucleosome assembly (GO:0034080)	3.42992365
25	DNA replication-dependent nucleosome organization (GO:0034723)	3.42932317
26	DNA replication-dependent nucleosome assembly (GO:0006335)	3.42932317
27	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.39137963
28	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.39137963
29	isotype switching (GO:0045190)	3.39137963
30	DNA replication checkpoint (GO:0000076)	3.28128317
31	DNA ligation (GO:0006266)	3.27342684
32	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.19295211
33	double-strand break repair via homologous recombination (GO:0000724)	3.16658256
34	recombinational repair (GO:0000725)	3.16442248
35	regulation of meiosis I (GO:0060631)	3.14804271
36	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.13158447
37	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.10042173
38	maturation of 5.8S rRNA (GO:0000460)	3.08118732
39	mitochondrial RNA metabolic process (GO:0000959)	3.07536541
40	DNA strand elongation involved in DNA replication (GO:0006271)	3.04852038
41	ribosome biogenesis (GO:0042254)	3.04535467
42	formation of translation preinitiation complex (GO:0001731)	3.04298772
43	histone exchange (GO:0043486)	3.03845556
44	double-strand break repair via nonhomologous end joining (GO:0006303)	3.02043862
45	non-recombinational repair (GO:0000726)	3.02043862
46	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.00945827
47	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.99482262
48	ribosome assembly (GO:0042255)	2.99441686
49	ribosomal small subunit assembly (GO:0000028)	2.97606449
50	kinetochore assembly (GO:0051382)	2.96825025
51	pseudouridine synthesis (GO:0001522)	2.96700410
52	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.96654454
53	regulation of mitotic spindle checkpoint (GO:1903504)	2.96654454
54	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.96406376
55	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.95845951
56	telomere maintenance via semi-conservative replication (GO:0032201)	2.94911455
57	DNA strand elongation (GO:0022616)	2.93092528
58	regulation of immunoglobulin secretion (GO:0051023)	2.92633996
59	ubiquinone metabolic process (GO:0006743)	2.92433556
60	base-excision repair, AP site formation (GO:0006285)	2.91811944
61	ubiquinone biosynthetic process (GO:0006744)	2.90026037
62	regulation of cellular amino acid metabolic process (GO:0006521)	2.89931310
63	mitotic metaphase plate congression (GO:0007080)	2.88471934
64	spliceosomal snRNP assembly (GO:0000387)	2.88022389
65	somatic diversification of immunoglobulins (GO:0016445)	2.87623158
66	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.87457140
67	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.87457140
68	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.87457140
69	isoprenoid biosynthetic process (GO:0008299)	2.85645712
70	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.85335832
71	piRNA metabolic process (GO:0034587)	2.83628445
72	regulation of mitochondrial translation (GO:0070129)	2.82931313
73	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.82236285
74	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.81182670
75	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.81182670
76	transcription from mitochondrial promoter (GO:0006390)	2.80957931
77	negative regulation of ligase activity (GO:0051352)	2.80321040
78	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.80321040
79	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.78571085
80	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.78571085
81	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.78356430
82	double-strand break repair (GO:0006302)	2.78141846
83	cullin deneddylation (GO:0010388)	2.77164165
84	aggressive behavior (GO:0002118)	2.76955930
85	oxidative phosphorylation (GO:0006119)	2.75587422
86	IMP biosynthetic process (GO:0006188)	2.72488062
87	rRNA processing (GO:0006364)	2.70963853
88	negative regulation of DNA recombination (GO:0045910)	2.70605370
89	tRNA processing (GO:0008033)	2.69382319
90	purine nucleobase biosynthetic process (GO:0009113)	2.66432621
91	negative regulation of mast cell activation (GO:0033004)	2.66342484
92	mitotic recombination (GO:0006312)	2.66036788
93	metaphase plate congression (GO:0051310)	2.65933622
94	nucleobase biosynthetic process (GO:0046112)	2.65862720
95	rRNA metabolic process (GO:0016072)	2.64897849
96	RNA phosphodiester bond hydrolysis (GO:0090501)	2.64450059
97	intra-S DNA damage checkpoint (GO:0031573)	2.64373473
98	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.64351225
99	regulation of centriole replication (GO:0046599)	2.64201860
100	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.63241901

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.04526402
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.88741251
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.81040298
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.78921201
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.46081241
6	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.43688559
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.28268670
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.99100714
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.92084277
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.87708827
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.71263304
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.65392886
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.60749374
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.57104995
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.56681993
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.53905558
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.51312511
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.39880328
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.39157576
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.31151548
21	VDR_22108803_ChIP-Seq_LS180_Human	2.30212239
22	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.25196726
23	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.22231802
24	ELK1_19687146_ChIP-ChIP_HELA_Human	2.19261781
25	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.19145224
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.10543364
27	IRF1_19129219_ChIP-ChIP_H3396_Human	2.06497438
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.97256741
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.95773273
30	EWS_26573619_Chip-Seq_HEK293_Human	1.87396682
31	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.86086925
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84662684
33	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.80927662
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.76512891
35	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.71902496
36	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.65272563
37	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57951407
38	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.57597417
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.57129436
40	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.55677024
41	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.54515771
42	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.53672694
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51546511
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.50726931
45	DCP1A_22483619_ChIP-Seq_HELA_Human	1.50326081
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.49116677
47	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.42846038
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.41844338
49	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.39839110
50	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.39735771
51	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.39373076
52	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.39199790
53	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.38611598
54	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.37920549
55	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.36892370
56	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.34996650
57	FUS_26573619_Chip-Seq_HEK293_Human	1.33419773
58	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32788616
59	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.32166800
60	XRN2_22483619_ChIP-Seq_HELA_Human	1.28316256
61	AR_21909140_ChIP-Seq_LNCAP_Human	1.28173687
62	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.22424368
63	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.21622450
64	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.19620996
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19414668
66	P300_19829295_ChIP-Seq_ESCs_Human	1.18577110
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.16449126
68	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.16278488
69	CIITA_25753668_ChIP-Seq_RAJI_Human	1.14526420
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10050780
71	TAF15_26573619_Chip-Seq_HEK293_Human	1.06690292
72	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.06267763
73	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.04172046
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01210072
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.99985972
76	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.99871073
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99704553
78	GBX2_23144817_ChIP-Seq_PC3_Human	0.98651255
79	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.98567272
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97881427
81	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.96984627
82	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.96856893
83	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.96752133
84	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.93317406
85	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.93296021
86	AR_20517297_ChIP-Seq_VCAP_Human	0.91071062
87	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.90409355
88	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.87773148
89	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.87773148
90	SOX2_19829295_ChIP-Seq_ESCs_Human	0.84831376
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.84831376
92	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.84383346
93	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.83870221
94	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.83789037
95	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.82083875
96	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.81528037
97	NCOR_22424771_ChIP-Seq_293T_Human	0.81382814
98	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.80531558
99	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.78264029
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.78264029

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.85456641
2	MP0003693_abnormal_embryo_hatching	4.28730661
3	MP0010094_abnormal_chromosome_stability	3.47734137
4	MP0008058_abnormal_DNA_repair	3.39234115
5	MP0008057_abnormal_DNA_replication	3.35420193
6	MP0008877_abnormal_DNA_methylation	3.34129382
7	MP0004957_abnormal_blastocyst_morpholog	2.55115796
8	MP0006072_abnormal_retinal_apoptosis	2.50221055
9	MP0003111_abnormal_nucleus_morphology	2.37516784
10	MP0003718_maternal_effect	2.35398708
11	MP0002102_abnormal_ear_morphology	2.34242925
12	MP0003786_premature_aging	2.27239638
13	MP0003077_abnormal_cell_cycle	2.16935438
14	MP0000372_irregular_coat_pigmentation	2.10528955
15	MP0008995_early_reproductive_senescence	2.08733477
16	MP0009697_abnormal_copulation	1.99752225
17	MP0005645_abnormal_hypothalamus_physiol	1.89984673
18	MP0001293_anophthalmia	1.88540098
19	MP0001529_abnormal_vocalization	1.88030586
20	MP0003567_abnormal_fetal_cardiomyocyte	1.86953121
21	MP0008872_abnormal_physiological_respon	1.73299798
22	MP0001764_abnormal_homeostasis	1.72565625
23	MP0000566_synostosis	1.64031617
24	MP0008932_abnormal_embryonic_tissue	1.61185673
25	MP0008875_abnormal_xenobiotic_pharmacok	1.51292042
26	MP0002234_abnormal_pharynx_morphology	1.50646806
27	MP0008789_abnormal_olfactory_epithelium	1.50403139
28	MP0003937_abnormal_limbs/digits/tail_de	1.49800497
29	MP0002210_abnormal_sex_determination	1.49106559
30	MP0006036_abnormal_mitochondrial_physio	1.48593860
31	MP0001929_abnormal_gametogenesis	1.45157606
32	MP0002938_white_spotting	1.29111372
33	MP0002233_abnormal_nose_morphology	1.24918993
34	MP0003806_abnormal_nucleotide_metabolis	1.24559477
35	MP0000653_abnormal_sex_gland	1.24503668
36	MP0001119_abnormal_female_reproductive	1.22380745
37	MP0000049_abnormal_middle_ear	1.21751705
38	MP0005253_abnormal_eye_physiology	1.21142103
39	MP0000631_abnormal_neuroendocrine_gland	1.18272987
40	MP0001145_abnormal_male_reproductive	1.17918458
41	MP0003646_muscle_fatigue	1.17516276
42	MP0005084_abnormal_gallbladder_morpholo	1.15531109
43	MP0001730_embryonic_growth_arrest	1.14110006
44	MP0005551_abnormal_eye_electrophysiolog	1.13989651
45	MP0002653_abnormal_ependyma_morphology	1.13547575
46	MP0003119_abnormal_digestive_system	1.13144090
47	MP0005075_abnormal_melanosome_morpholog	1.10929449
48	MP0004043_abnormal_pH_regulation	1.10705378
49	MP0005671_abnormal_response_to	1.09886475
50	MP0005394_taste/olfaction_phenotype	1.07327352
51	MP0005499_abnormal_olfactory_system	1.07327352
52	MP0002090_abnormal_vision	1.05670637
53	MP0002160_abnormal_reproductive_system	1.03879432
54	MP0002837_dystrophic_cardiac_calcinosis	1.03818968
55	MP0002006_tumorigenesis	1.03058106
56	MP0005410_abnormal_fertilization	1.00921294
57	MP0003890_abnormal_embryonic-extraembry	1.00591380
58	MP0005389_reproductive_system_phenotype	0.98073288
59	MP0003698_abnormal_male_reproductive	0.96256040
60	MP0006035_abnormal_mitochondrial_morpho	0.94633973
61	MP0004133_heterotaxia	0.94382403
62	MP0002751_abnormal_autonomic_nervous	0.93281153
63	MP0003938_abnormal_ear_development	0.92726883
64	MP0003186_abnormal_redox_activity	0.91490509
65	MP0002736_abnormal_nociception_after	0.89243261
66	MP0001873_stomach_inflammation	0.88115719
67	MP0008007_abnormal_cellular_replicative	0.84929205
68	MP0005391_vision/eye_phenotype	0.83340087
69	MP0001835_abnormal_antigen_presentation	0.82966612
70	MP0005646_abnormal_pituitary_gland	0.82060696
71	MP0005395_other_phenotype	0.80582400
72	MP0001286_abnormal_eye_development	0.80504949
73	MP0004145_abnormal_muscle_electrophysio	0.80362477
74	MP0002084_abnormal_developmental_patter	0.79639688
75	MP0003136_yellow_coat_color	0.79139150
76	MP0000490_abnormal_crypts_of	0.79126429
77	MP0001697_abnormal_embryo_size	0.78922852
78	MP0001485_abnormal_pinna_reflex	0.77530112
79	MP0005195_abnormal_posterior_eye	0.77425747
80	MP0005377_hearing/vestibular/ear_phenot	0.74034967
81	MP0003878_abnormal_ear_physiology	0.74034967
82	MP0003137_abnormal_impulse_conducting	0.74021468
83	MP0002085_abnormal_embryonic_tissue	0.73676208
84	MP0001919_abnormal_reproductive_system	0.73267471
85	MP0002163_abnormal_gland_morphology	0.72292043
86	MP0004215_abnormal_myocardial_fiber	0.71104692
87	MP0004147_increased_porphyrin_level	0.71038161
88	MP0004142_abnormal_muscle_tone	0.70725287
89	MP0002638_abnormal_pupillary_reflex	0.70352248
90	MP0003252_abnormal_bile_duct	0.69920694
91	MP0002019_abnormal_tumor_incidence	0.69495264
92	MP0005380_embryogenesis_phenotype	0.69187597
93	MP0001672_abnormal_embryogenesis/_devel	0.69187597
94	MP0003936_abnormal_reproductive_system	0.65757434
95	MP0002735_abnormal_chemical_nociception	0.65663681
96	MP0002928_abnormal_bile_duct	0.65275460
97	MP0002161_abnormal_fertility/fecundity	0.63886910
98	MP0000313_abnormal_cell_death	0.63233110
99	MP0003880_abnormal_central_pattern	0.63171535
100	MP0005085_abnormal_gallbladder_physiolo	0.61635441

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.91206999
2	Abnormality of the ileum (HP:0001549)	3.86320863
3	Meckel diverticulum (HP:0002245)	3.82113337
4	Acute necrotizing encephalopathy (HP:0006965)	3.76031049
5	Colon cancer (HP:0003003)	3.71223021
6	Acute encephalopathy (HP:0006846)	3.60967365
7	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.59658072
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.36512478
9	Abnormality of the labia minora (HP:0012880)	3.20106174
10	Supernumerary spleens (HP:0009799)	3.15795271
11	Progressive macrocephaly (HP:0004481)	3.14981466
12	Abnormality of the preputium (HP:0100587)	3.06239567
13	Mitochondrial inheritance (HP:0001427)	3.04978881
14	Bile duct proliferation (HP:0001408)	3.02012772
15	Abnormal biliary tract physiology (HP:0012439)	3.02012772
16	Abnormality of chromosome stability (HP:0003220)	2.95545772
17	Pancreatic cysts (HP:0001737)	2.93419557
18	Hepatocellular necrosis (HP:0001404)	2.89582691
19	Increased CSF lactate (HP:0002490)	2.87183045
20	Increased hepatocellular lipid droplets (HP:0006565)	2.85818318
21	Small intestinal stenosis (HP:0012848)	2.80735412
22	Duodenal stenosis (HP:0100867)	2.80735412
23	Cerebral edema (HP:0002181)	2.74379538
24	True hermaphroditism (HP:0010459)	2.73907192
25	Chromsome breakage (HP:0040012)	2.70904972
26	Absent thumb (HP:0009777)	2.69169704
27	Pancreatic fibrosis (HP:0100732)	2.67901259
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.67024259
29	Lipid accumulation in hepatocytes (HP:0006561)	2.66060337
30	Abnormal lung lobation (HP:0002101)	2.63784366
31	Hyperglycinemia (HP:0002154)	2.60038893
32	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.56851018
33	Hepatic necrosis (HP:0002605)	2.56609221
34	Abnormality of midbrain morphology (HP:0002418)	2.55151939
35	Molar tooth sign on MRI (HP:0002419)	2.55151939
36	Increased serum lactate (HP:0002151)	2.53731430
37	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.52511763
38	Ependymoma (HP:0002888)	2.46535317
39	Stomatitis (HP:0010280)	2.44251305
40	Clubbing of toes (HP:0100760)	2.43853632
41	Abnormality of the carotid arteries (HP:0005344)	2.42575236
42	Abnormality of the duodenum (HP:0002246)	2.41939219
43	Dyschromatopsia (HP:0007641)	2.40507219
44	Hyperglycinuria (HP:0003108)	2.38165173
45	Asplenia (HP:0001746)	2.37452554
46	Abnormality of serine family amino acid metabolism (HP:0010894)	2.37379295
47	Abnormality of glycine metabolism (HP:0010895)	2.37379295
48	Nephronophthisis (HP:0000090)	2.26122928
49	Ectopic kidney (HP:0000086)	2.24312420
50	Abolished electroretinogram (ERG) (HP:0000550)	2.16775125
51	Sloping forehead (HP:0000340)	2.13651842
52	Triphalangeal thumb (HP:0001199)	2.12849976
53	Abnormality of DNA repair (HP:0003254)	2.12140304
54	Type I transferrin isoform profile (HP:0003642)	2.10079245
55	Increased intramyocellular lipid droplets (HP:0012240)	2.08731567
56	Abnormality of the renal medulla (HP:0100957)	2.07394701
57	Lactic acidosis (HP:0003128)	2.04983310
58	Degeneration of anterior horn cells (HP:0002398)	2.04794756
59	Abnormality of the anterior horn cell (HP:0006802)	2.04794756
60	Abnormality of the renal cortex (HP:0011035)	2.02365652
61	Pancreatic islet-cell hyperplasia (HP:0004510)	1.99433166
62	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.97948127
63	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.97948127
64	Rhabdomyosarcoma (HP:0002859)	1.95986746
65	Horseshoe kidney (HP:0000085)	1.93890106
66	Attenuation of retinal blood vessels (HP:0007843)	1.93567643
67	Tubular atrophy (HP:0000092)	1.93184228
68	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.92880198
69	Optic disc pallor (HP:0000543)	1.92872986
70	Pendular nystagmus (HP:0012043)	1.90905511
71	Oligohydramnios (HP:0001562)	1.90814342
72	Respiratory failure (HP:0002878)	1.90273896
73	Exercise intolerance (HP:0003546)	1.88968837
74	Renal Fanconi syndrome (HP:0001994)	1.88173040
75	Type 2 muscle fiber atrophy (HP:0003554)	1.88041176
76	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.87620879
77	Optic nerve hypoplasia (HP:0000609)	1.86835224
78	3-Methylglutaconic aciduria (HP:0003535)	1.86441772
79	Myelodysplasia (HP:0002863)	1.80792528
80	Abnormality of serum amino acid levels (HP:0003112)	1.80199158
81	IgG deficiency (HP:0004315)	1.79650824
82	Gonadotropin excess (HP:0000837)	1.78518811
83	Progressive inability to walk (HP:0002505)	1.77228488
84	Cystic liver disease (HP:0006706)	1.75723058
85	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.74919116
86	Lethargy (HP:0001254)	1.72527265
87	Abnormal protein glycosylation (HP:0012346)	1.72417537
88	Abnormal glycosylation (HP:0012345)	1.72417537
89	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.72417537
90	Abnormal protein N-linked glycosylation (HP:0012347)	1.72417537
91	Congenital stationary night blindness (HP:0007642)	1.71932845
92	Hypoplasia of the pons (HP:0012110)	1.71154698
93	Hypoproteinemia (HP:0003075)	1.70653434
94	Adrenal hypoplasia (HP:0000835)	1.70555502
95	Nephroblastoma (Wilms tumor) (HP:0002667)	1.70089960
96	Renal cortical cysts (HP:0000803)	1.69160186
97	Pancytopenia (HP:0001876)	1.68688714
98	Increased muscle lipid content (HP:0009058)	1.67905920
99	Intestinal atresia (HP:0011100)	1.66678178
100	Increased serum pyruvate (HP:0003542)	1.66626648

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.93373168
2	CDC7	3.19708146
3	SRPK1	3.10944719
4	TLK1	3.08646595
5	CCNB1	3.06594801
6	BUB1	2.84328514
7	VRK2	2.82830853
8	NUAK1	2.58740103
9	MKNK1	2.55002879
10	MAP4K2	2.39124962
11	PLK4	2.38440715
12	VRK1	2.28615892
13	TSSK6	2.26689184
14	PBK	2.16556295
15	CDK19	2.05976792
16	MST4	1.88719824
17	WEE1	1.88111679
18	PLK3	1.70928068
19	STK16	1.69443218
20	BCKDK	1.67729477
21	MKNK2	1.67363420
22	NEK1	1.60446972
23	PINK1	1.59942172
24	WNK3	1.54619824
25	WNK4	1.54464728
26	EIF2AK3	1.50320649
27	TXK	1.41506886
28	STK39	1.41475114
29	EIF2AK1	1.41086471
30	ATR	1.37410260
31	PLK1	1.35448620
32	TTK	1.29483504
33	GRK1	1.20999513
34	OXSR1	1.15179106
35	TRIM28	1.13414673
36	BCR	1.10671805
37	CHEK2	1.10299070
38	BMPR1B	1.04094133
39	FLT3	1.02601496
40	INSRR	1.01890175
41	AURKB	1.01632131
42	CSNK1G1	1.00144022
43	CSNK1G3	0.99743528
44	TAF1	0.96863827
45	NEK2	0.94235765
46	MAP3K4	0.93789059
47	RPS6KA5	0.93004448
48	CSNK1G2	0.92652353
49	CSNK1A1L	0.89507779
50	ACVR1B	0.88873021
51	ADRBK2	0.84880129
52	RPS6KA4	0.84460061
53	KDR	0.83824730
54	AURKA	0.79396488
55	MUSK	0.74589812
56	FRK	0.70703241
57	ATM	0.70541154
58	EIF2AK2	0.67265057
59	CDK7	0.63621101
60	ERBB3	0.63473271
61	PLK2	0.62802691
62	CDK8	0.62587686
63	MAPKAPK5	0.62173784
64	DYRK2	0.61905800
65	NME1	0.61900586
66	LIMK1	0.58541910
67	TAOK3	0.58305547
68	CHEK1	0.56865086
69	TNIK	0.56677145
70	MAP2K7	0.55246203
71	TIE1	0.54116938
72	CSNK2A1	0.51916332
73	CDK4	0.51778157
74	ITK	0.51316781
75	PASK	0.49653219
76	CSNK1A1	0.46952107
77	DAPK1	0.44762146
78	MAPK13	0.44016059
79	MELK	0.40357568
80	STK3	0.40227686
81	CSNK2A2	0.39620889
82	BRSK2	0.39196293
83	TGFBR1	0.37796081
84	PRKCQ	0.36608454
85	TEC	0.35832786
86	PRKCE	0.33524521
87	TESK2	0.33347913
88	KIT	0.33347407
89	OBSCN	0.33053425
90	CDK9	0.31028218
91	PKN2	0.30768923
92	CSNK1E	0.30527822
93	CDK1	0.28198597
94	MAP3K8	0.27919048
95	DYRK3	0.27910508
96	PHKG1	0.27222719
97	PHKG2	0.27222719
98	STK38L	0.26897237
99	MARK3	0.25110641
100	PRKDC	0.24914209

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.58938327
2	DNA replication_Homo sapiens_hsa03030	3.02567817
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.01175631
4	Base excision repair_Homo sapiens_hsa03410	2.77537838
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.74473902
6	Mismatch repair_Homo sapiens_hsa03430	2.61866305
7	Protein export_Homo sapiens_hsa03060	2.52391912
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.35611899
9	Homologous recombination_Homo sapiens_hsa03440	2.28247337
10	Asthma_Homo sapiens_hsa05310	2.17433805
11	Nucleotide excision repair_Homo sapiens_hsa03420	2.13005677
12	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.11280699
13	RNA transport_Homo sapiens_hsa03013	2.07386656
14	Basal transcription factors_Homo sapiens_hsa03022	2.02116501
15	Spliceosome_Homo sapiens_hsa03040	2.01954455
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.95107483
17	Propanoate metabolism_Homo sapiens_hsa00640	1.88601798
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.85493336
19	Parkinsons disease_Homo sapiens_hsa05012	1.85277630
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.78110069
21	Allograft rejection_Homo sapiens_hsa05330	1.75864444
22	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.74501875
23	RNA degradation_Homo sapiens_hsa03018	1.73667501
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.58338764
25	One carbon pool by folate_Homo sapiens_hsa00670	1.56106793
26	Steroid biosynthesis_Homo sapiens_hsa00100	1.48847674
27	Ribosome_Homo sapiens_hsa03010	1.46450618
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.44818354
29	RNA polymerase_Homo sapiens_hsa03020	1.43245003
30	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.37174868
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.37160368
32	Graft-versus-host disease_Homo sapiens_hsa05332	1.36231354
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31660588
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29437124
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26533648
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.22965253
37	Huntingtons disease_Homo sapiens_hsa05016	1.20281554
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13476464
39	Linoleic acid metabolism_Homo sapiens_hsa00591	1.13237233
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.10871869
41	Antigen processing and presentation_Homo sapiens_hsa04612	1.10375732
42	Cell cycle_Homo sapiens_hsa04110	1.09227571
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.08456205
44	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.07324712
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.07118417
46	Primary immunodeficiency_Homo sapiens_hsa05340	1.04665536
47	Alcoholism_Homo sapiens_hsa05034	1.03545179
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.02551347
49	Purine metabolism_Homo sapiens_hsa00230	0.98033357
50	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.87577245
51	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.86611657
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.81257993
53	Alzheimers disease_Homo sapiens_hsa05010	0.79711264
54	Butanoate metabolism_Homo sapiens_hsa00650	0.79300582
55	Phototransduction_Homo sapiens_hsa04744	0.78057125
56	Fatty acid elongation_Homo sapiens_hsa00062	0.77558198
57	mRNA surveillance pathway_Homo sapiens_hsa03015	0.77089749
58	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.75804788
59	Carbon metabolism_Homo sapiens_hsa01200	0.75507254
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.70669310
61	Peroxisome_Homo sapiens_hsa04146	0.70395240
62	Sulfur metabolism_Homo sapiens_hsa00920	0.69928948
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.67475081
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.65253433
65	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.60348779
66	Oocyte meiosis_Homo sapiens_hsa04114	0.60184071
67	Caffeine metabolism_Homo sapiens_hsa00232	0.60029808
68	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.59846491
69	Metabolic pathways_Homo sapiens_hsa01100	0.59791011
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58779576
71	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.58441232
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.54558660
73	Olfactory transduction_Homo sapiens_hsa04740	0.52857071
74	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.52565381
75	Folate biosynthesis_Homo sapiens_hsa00790	0.51801608
76	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.51632987
77	Regulation of autophagy_Homo sapiens_hsa04140	0.51601542
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51272349
79	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.47399362
80	Glutathione metabolism_Homo sapiens_hsa00480	0.46841825
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45509368
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43179055
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42805772
84	Herpes simplex infection_Homo sapiens_hsa05168	0.42260671
85	Rheumatoid arthritis_Homo sapiens_hsa05323	0.41701631
86	Retinol metabolism_Homo sapiens_hsa00830	0.40655084
87	Fatty acid degradation_Homo sapiens_hsa00071	0.40611570
88	Sulfur relay system_Homo sapiens_hsa04122	0.40134018
89	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.38688579
90	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.37899273
91	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.37473775
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.37439591
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36958867
94	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.36009819
95	p53 signaling pathway_Homo sapiens_hsa04115	0.35938290
96	Legionellosis_Homo sapiens_hsa05134	0.34910685
97	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.34219883
98	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.33909074
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33674294
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33122586

HNRNPA1P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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