HNRNPA1P73

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukotriene biosynthetic process (GO:0019370)6.39909664
2base-excision repair, AP site formation (GO:0006285)6.34222038
3positive regulation of protein homodimerization activity (GO:0090073)6.25175286
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.13462659
5preassembly of GPI anchor in ER membrane (GO:0016254)5.88102588
6regulation of hypersensitivity (GO:0002883)5.69622534
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.62601647
8ATP synthesis coupled proton transport (GO:0015986)5.62601647
9positive regulation of mast cell degranulation (GO:0043306)5.42763846
10positive regulation of mast cell activation involved in immune response (GO:0033008)5.42763846
11positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.25294460
12negative regulation of calcium ion transport into cytosol (GO:0010523)4.92737806
13neuronal action potential propagation (GO:0019227)4.87555208
14negative regulation of phosphoprotein phosphatase activity (GO:0032515)4.70114830
15galactose catabolic process (GO:0019388)4.50480415
16positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.50256631
17positive regulation of mast cell activation (GO:0033005)4.49351851
18cysteine metabolic process (GO:0006534)4.48984992
19Arp2/3 complex-mediated actin nucleation (GO:0034314)4.39643519
20NADH dehydrogenase complex assembly (GO:0010257)4.39566714
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.39566714
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.39566714
23negative regulation of heart rate (GO:0010459)4.37266476
24GPI anchor biosynthetic process (GO:0006506)4.35644787
25protein complex biogenesis (GO:0070271)4.21940071
26GPI anchor metabolic process (GO:0006505)4.17716274
27regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.11188456
28actin nucleation (GO:0045010)3.99103300
29negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.85916905
30regulation of T cell receptor signaling pathway (GO:0050856)3.84205737
31positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.83815965
32hepatocyte differentiation (GO:0070365)3.82731764
33prenylation (GO:0097354)3.78432649
34protein prenylation (GO:0018342)3.78432649
35leukotriene metabolic process (GO:0006691)3.77315443
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.77122431
37protein maturation by protein folding (GO:0022417)3.76472601
38axonemal dynein complex assembly (GO:0070286)3.75959846
39mitochondrial respiratory chain complex assembly (GO:0033108)3.75253348
40chaperone-mediated protein transport (GO:0072321)3.74764937
41behavioral response to nicotine (GO:0035095)3.73977447
42icosanoid biosynthetic process (GO:0046456)3.70461412
43fatty acid derivative biosynthetic process (GO:1901570)3.70461412
44response to vitamin E (GO:0033197)3.69626792
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.66365114
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.62126978
47regulation of autophagic vacuole assembly (GO:2000785)3.61970894
48signal peptide processing (GO:0006465)3.61872592
49mitochondrial calcium ion transport (GO:0006851)3.59233315
50regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.59022115
51regulation of germinal center formation (GO:0002634)3.58482159
52positive regulation of leukocyte degranulation (GO:0043302)3.57087943
53dopamine transport (GO:0015872)3.55973718
54DNA catabolic process, exonucleolytic (GO:0000738)3.50921477
55fucose catabolic process (GO:0019317)3.46602077
56L-fucose metabolic process (GO:0042354)3.46602077
57L-fucose catabolic process (GO:0042355)3.46602077
58ATP biosynthetic process (GO:0006754)3.44648142
59protein neddylation (GO:0045116)3.43267084
60mature B cell differentiation (GO:0002335)3.42132142
61cellular response to interleukin-15 (GO:0071350)3.41657295
62positive regulation of oligodendrocyte differentiation (GO:0048714)3.41599692
63protein localization to cilium (GO:0061512)3.40798128
64monoamine transport (GO:0015844)3.39611233
65C-terminal protein lipidation (GO:0006501)3.38855176
66protein polyglutamylation (GO:0018095)3.37010797
67ribosomal small subunit assembly (GO:0000028)3.26735721
68protein peptidyl-prolyl isomerization (GO:0000413)3.25451063
69cilium or flagellum-dependent cell motility (GO:0001539)3.21040441
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.19400307
71cell wall macromolecule catabolic process (GO:0016998)3.14918453
72respiratory electron transport chain (GO:0022904)3.14382071
73negative regulation of mast cell activation (GO:0033004)3.10544797
74electron transport chain (GO:0022900)3.10406043
75unsaturated fatty acid biosynthetic process (GO:0006636)3.09481459
76deoxyribose phosphate catabolic process (GO:0046386)3.09307908
77regulation of mast cell activation (GO:0033003)3.04216172
78positive regulation of T cell cytokine production (GO:0002726)3.02821094
79regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.98531982
80arginine metabolic process (GO:0006525)2.97744291
81T cell proliferation (GO:0042098)2.96297483
82response to pheromone (GO:0019236)2.90171665
83purine nucleoside triphosphate biosynthetic process (GO:0009145)2.90109473
84oogenesis (GO:0048477)2.88552249
85purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.85240978
86regulation of vacuole organization (GO:0044088)2.83595062
87C-terminal protein amino acid modification (GO:0018410)2.82638347
88mitochondrion distribution (GO:0048311)2.80632398
89regulation of neuron projection regeneration (GO:0070570)2.79396969
90regulation of axon regeneration (GO:0048679)2.79396969
91positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.77726498
92mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.77726498
93negative regulation of meiotic cell cycle (GO:0051447)2.76121397
94somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.72275011
95somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.72275011
96isotype switching (GO:0045190)2.72275011
97protein K63-linked deubiquitination (GO:0070536)2.71250472
98cell wall macromolecule metabolic process (GO:0044036)2.71075792
99tachykinin receptor signaling pathway (GO:0007217)2.70404563
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69078962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.07415855
2TAF15_26573619_Chip-Seq_HEK293_Human4.05329909
3VDR_22108803_ChIP-Seq_LS180_Human3.47948729
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.28250883
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21585756
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.59738580
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.59053415
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.55956278
9AR_21572438_ChIP-Seq_LNCaP_Human2.47100133
10IRF1_19129219_ChIP-ChIP_H3396_Human2.35664327
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32202577
12EWS_26573619_Chip-Seq_HEK293_Human2.21337558
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18805318
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.16922878
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16588794
16IGF1R_20145208_ChIP-Seq_DFB_Human2.11706697
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.05837180
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.00519984
19P300_19829295_ChIP-Seq_ESCs_Human1.99548204
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97703163
21NANOG_19829295_ChIP-Seq_ESCs_Human1.91824105
22SOX2_19829295_ChIP-Seq_ESCs_Human1.91824105
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88992030
24GATA3_26560356_Chip-Seq_TH2_Human1.88182025
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87290653
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85122974
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.84784427
28VDR_23849224_ChIP-Seq_CD4+_Human1.80092880
29MYC_18940864_ChIP-ChIP_HL60_Human1.75672248
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.71503133
31TP53_22573176_ChIP-Seq_HFKS_Human1.70795266
32ERG_20517297_ChIP-Seq_VCAP_Human1.68151843
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67254427
34ER_23166858_ChIP-Seq_MCF-7_Human1.66876107
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60394684
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57005319
37PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.54352105
38ZNF274_21170338_ChIP-Seq_K562_Hela1.53877882
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53243615
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.51484415
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.49571563
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48319383
43FUS_26573619_Chip-Seq_HEK293_Human1.46532372
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43551307
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41497113
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41116872
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41076698
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.38652956
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.36986590
50MYB_26560356_Chip-Seq_TH2_Human1.35240279
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32600239
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30262635
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27748697
54ELK1_19687146_ChIP-ChIP_HELA_Human1.26260153
55FOXH1_21741376_ChIP-Seq_EPCs_Human1.26106772
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.25352523
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25352523
58AR_20517297_ChIP-Seq_VCAP_Human1.24608690
59CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24113636
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23672360
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.20120643
62GATA3_26560356_Chip-Seq_TH1_Human1.19834026
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18990108
64FOXP3_21729870_ChIP-Seq_TREG_Human1.18741039
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16391286
66SMRT_27268052_Chip-Seq_Bcells_Human1.15891737
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14577903
68MYC_19829295_ChIP-Seq_ESCs_Human1.13229432
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12935162
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12462270
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11298354
72AR_25329375_ChIP-Seq_VCAP_Human1.11228073
73EZH2_22144423_ChIP-Seq_EOC_Human1.11154268
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11026345
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09331991
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.07833115
77HOXB7_26014856_ChIP-Seq_BT474_Human1.07094715
78CBP_20019798_ChIP-Seq_JUKART_Human1.05805580
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05805580
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.04949186
81TCF4_22108803_ChIP-Seq_LS180_Human1.04304158
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01848270
83RUNX2_22187159_ChIP-Seq_PCA_Human0.98532507
84GATA3_27048872_Chip-Seq_THYMUS_Human0.97616505
85ERA_21632823_ChIP-Seq_H3396_Human0.96544525
86FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96540922
87SRF_21415370_ChIP-Seq_HL-1_Mouse0.96485931
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95774950
89ETS1_20019798_ChIP-Seq_JURKAT_Human0.93305471
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91796058
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90470298
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.89184236
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89115864
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88588927
95NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88257024
96SPI1_20517297_ChIP-Seq_HL60_Human0.87118884
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86540890
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.86009074
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85892982
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85884421

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.21433893
2MP0002166_altered_tumor_susceptibility3.11574771
3MP0003724_increased_susceptibility_to2.89915653
4MP0006072_abnormal_retinal_apoptosis2.86908679
5MP0001986_abnormal_taste_sensitivity2.67552091
6MP0005671_abnormal_response_to2.66005179
7MP0008995_early_reproductive_senescence2.60537845
8MP0005084_abnormal_gallbladder_morpholo2.59938943
9MP0000372_irregular_coat_pigmentation2.41167011
10MP0002009_preneoplasia2.39244091
11MP0002006_tumorigenesis2.37692520
12MP0003950_abnormal_plasma_membrane2.37677806
13MP0003183_abnormal_peptide_metabolism2.19277487
14MP0000685_abnormal_immune_system2.15766055
15MP0002822_catalepsy2.11514240
16MP0004147_increased_porphyrin_level2.08005661
17MP0003787_abnormal_imprinting2.06668259
18MP0006054_spinal_hemorrhage2.04148581
19MP0001835_abnormal_antigen_presentation2.02391656
20MP0001800_abnormal_humoral_immune2.01048615
21MP0008877_abnormal_DNA_methylation1.88574387
22MP0005377_hearing/vestibular/ear_phenot1.88093363
23MP0003878_abnormal_ear_physiology1.88093363
24MP0009785_altered_susceptibility_to1.85890333
25MP0003693_abnormal_embryo_hatching1.82129097
26MP0002163_abnormal_gland_morphology1.77341378
27MP0009379_abnormal_foot_pigmentation1.74012579
28MP0008872_abnormal_physiological_respon1.70361183
29MP0008775_abnormal_heart_ventricle1.70117782
30MP0009764_decreased_sensitivity_to1.69636784
31MP0005253_abnormal_eye_physiology1.59542520
32MP0002277_abnormal_respiratory_mucosa1.57748803
33MP0005167_abnormal_blood-brain_barrier1.52314773
34MP0009697_abnormal_copulation1.47068471
35MP0002723_abnormal_immune_serum1.46801068
36MP0002452_abnormal_antigen_presenting1.45113329
37MP0008961_abnormal_basal_metabolism1.44633234
38MP0005645_abnormal_hypothalamus_physiol1.44575164
39MP0004885_abnormal_endolymph1.41228229
40MP0002638_abnormal_pupillary_reflex1.40458651
41MP0005551_abnormal_eye_electrophysiolog1.40126470
42MP0005367_renal/urinary_system_phenotyp1.36906697
43MP0000516_abnormal_urinary_system1.36906697
44MP0006035_abnormal_mitochondrial_morpho1.34677408
45MP0008875_abnormal_xenobiotic_pharmacok1.32871916
46MP0001919_abnormal_reproductive_system1.31858685
47MP0002933_joint_inflammation1.28741299
48MP0002102_abnormal_ear_morphology1.27004329
49MP0002148_abnormal_hypersensitivity_rea1.23063340
50MP0001819_abnormal_immune_cell1.21968263
51MP0002420_abnormal_adaptive_immunity1.21615531
52MP0009333_abnormal_splenocyte_physiolog1.20479360
53MP0005379_endocrine/exocrine_gland_phen1.19762397
54MP0005389_reproductive_system_phenotype1.19724499
55MP0005085_abnormal_gallbladder_physiolo1.19679233
56MP0002736_abnormal_nociception_after1.19541171
57MP0001764_abnormal_homeostasis1.19302343
58MP0000579_abnormal_nail_morphology1.15594480
59MP0001905_abnormal_dopamine_level1.15352744
60MP0006276_abnormal_autonomic_nervous1.13687021
61MP0003195_calcinosis1.13153824
62MP0001501_abnormal_sleep_pattern1.10964010
63MP0004381_abnormal_hair_follicle1.07752068
64MP0002234_abnormal_pharynx_morphology1.04817551
65MP0003436_decreased_susceptibility_to1.04784686
66MP0010386_abnormal_urinary_bladder1.00001132
67MP0005646_abnormal_pituitary_gland0.99743194
68MP0001853_heart_inflammation0.99657800
69MP0002928_abnormal_bile_duct0.96108199
70MP0000465_gastrointestinal_hemorrhage0.94874443
71MP0000538_abnormal_urinary_bladder0.94589217
72MP0001968_abnormal_touch/_nociception0.93267601
73MP0001765_abnormal_ion_homeostasis0.93252257
74MP0001970_abnormal_pain_threshold0.92058898
75MP0005332_abnormal_amino_acid0.91611893
76MP0000647_abnormal_sebaceous_gland0.91532698
77MP0005000_abnormal_immune_tolerance0.90711058
78MP0004145_abnormal_muscle_electrophysio0.89899829
79MP0003567_abnormal_fetal_cardiomyocyte0.89175467
80MP0005410_abnormal_fertilization0.88303190
81MP0003136_yellow_coat_color0.87130137
82MP0002909_abnormal_adrenal_gland0.86189822
83MP0005025_abnormal_response_to0.85392365
84MP0004484_altered_response_of0.84482698
85MP0004142_abnormal_muscle_tone0.83222606
86MP0002751_abnormal_autonomic_nervous0.82862402
87MP0000230_abnormal_systemic_arterial0.82420449
88MP0003786_premature_aging0.81515294
89MP0002733_abnormal_thermal_nociception0.79887144
90MP0002419_abnormal_innate_immunity0.79575595
91MP0002160_abnormal_reproductive_system0.79019090
92MP0001119_abnormal_female_reproductive0.78982986
93MP0003011_delayed_dark_adaptation0.77446577
94MP0003656_abnormal_erythrocyte_physiolo0.75781925
95MP0001845_abnormal_inflammatory_respons0.75365110
96MP0002398_abnormal_bone_marrow0.75067930
97MP0001533_abnormal_skeleton_physiology0.74035698
98MP0000716_abnormal_immune_system0.72744247
99MP0006036_abnormal_mitochondrial_physio0.72378917
100MP0003866_abnormal_defecation0.69072744

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.37399541
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.19238616
3Absent/shortened dynein arms (HP:0200106)4.19238616
4Azoospermia (HP:0000027)4.10154325
5Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.58466319
6Lipid accumulation in hepatocytes (HP:0006561)3.51920159
7Supernumerary spleens (HP:0009799)3.49457161
8B lymphocytopenia (HP:0010976)3.27179796
9Chronic sinusitis (HP:0011109)3.24239418
10Abnormality of B cell number (HP:0010975)3.23553765
11Abnormal respiratory epithelium morphology (HP:0012253)3.22323172
12Abnormal respiratory motile cilium morphology (HP:0005938)3.22323172
13Stomatitis (HP:0010280)3.13590573
14Abnormal respiratory motile cilium physiology (HP:0012261)3.12077186
15Elevated erythrocyte sedimentation rate (HP:0003565)3.11539457
16Abnormality of lateral ventricle (HP:0030047)3.10856765
17Increased hepatocellular lipid droplets (HP:0006565)3.10243236
18Hepatocellular necrosis (HP:0001404)3.06187751
19Abnormal ciliary motility (HP:0012262)3.05704259
20Abnormal spermatogenesis (HP:0008669)3.01544720
21Chronic bronchitis (HP:0004469)2.98285674
22Colon cancer (HP:0003003)2.95994744
23Stomach cancer (HP:0012126)2.90099266
24Bronchitis (HP:0012387)2.88872263
25Increased CSF lactate (HP:0002490)2.86237808
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.83108570
27Recurrent bronchitis (HP:0002837)2.82400543
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.77654342
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.77654342
30Tented upper lip vermilion (HP:0010804)2.76872286
31Abnormality of glycolipid metabolism (HP:0010969)2.71962941
32Abnormality of liposaccharide metabolism (HP:0010968)2.71962941
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.71962941
34Mitochondrial inheritance (HP:0001427)2.71562443
35Premature ovarian failure (HP:0008209)2.69902393
36Severe combined immunodeficiency (HP:0004430)2.65398934
37Large for gestational age (HP:0001520)2.63937332
38Hypomagnesemia (HP:0002917)2.60914734
39T lymphocytopenia (HP:0005403)2.52367886
40Autoimmune hemolytic anemia (HP:0001890)2.51207040
41True hermaphroditism (HP:0010459)2.44303294
42Hepatic necrosis (HP:0002605)2.43658233
43CNS demyelination (HP:0007305)2.42287543
44Testicular atrophy (HP:0000029)2.39551122
45Chronic diarrhea (HP:0002028)2.38503622
46Erythroderma (HP:0001019)2.30890490
47Increased IgM level (HP:0003496)2.30460616
48Thyroiditis (HP:0100646)2.28836576
49Type II lissencephaly (HP:0007260)2.27104860
50Bronchiectasis (HP:0002110)2.26161288
51Abnormality of T cell number (HP:0011839)2.24278174
52Anhidrosis (HP:0000970)2.22081959
53Molar tooth sign on MRI (HP:0002419)2.20830919
54Abnormality of midbrain morphology (HP:0002418)2.20830919
55Abnormality of eosinophils (HP:0001879)2.19162249
56Abnormality of magnesium homeostasis (HP:0004921)2.17804163
57Renal Fanconi syndrome (HP:0001994)2.13084417
58Tetany (HP:0001281)2.12401449
59Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.11948713
60Abnormality of dental color (HP:0011073)2.11328974
61Increased muscle lipid content (HP:0009058)2.10651753
62Abnormality of fatty-acid metabolism (HP:0004359)2.09223793
633-Methylglutaconic aciduria (HP:0003535)2.09167818
64Concave nail (HP:0001598)2.08725430
65Brittle hair (HP:0002299)2.08001995
66Increased intramyocellular lipid droplets (HP:0012240)2.06398279
67Medulloblastoma (HP:0002885)2.04127593
68Nephronophthisis (HP:0000090)2.03785902
69Conical tooth (HP:0000698)2.02821321
70Large eyes (HP:0001090)2.01541411
71Duplicated collecting system (HP:0000081)1.98030543
72Dyskinesia (HP:0100660)1.96849269
73Congenital stationary night blindness (HP:0007642)1.95743429
74Abnormality of the pons (HP:0007361)1.94316715
75Hypothermia (HP:0002045)1.94111828
76Male pseudohermaphroditism (HP:0000037)1.93710994
77Flared iliac wings (HP:0002869)1.92864735
78Combined immunodeficiency (HP:0005387)1.89998013
79Abnormality of the renal collecting system (HP:0004742)1.88274457
80Pulmonary infiltrates (HP:0002113)1.87369532
81Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86871481
82Abnormality of the labia minora (HP:0012880)1.85986196
83Facial diplegia (HP:0001349)1.84740456
84Neoplasm of the tracheobronchial system (HP:0100552)1.84056907
85Abnormality of the prostate (HP:0008775)1.83621425
86Pancreatitis (HP:0001733)1.82906113
87Broad alveolar ridges (HP:0000187)1.82119367
88Abnormality of T cells (HP:0002843)1.81723903
89Chronic hepatic failure (HP:0100626)1.81157932
90Recurrent pneumonia (HP:0006532)1.80981906
91Sensorimotor neuropathy (HP:0007141)1.80928834
92Pancreatic fibrosis (HP:0100732)1.80922060
93Eosinophilia (HP:0001880)1.80619051
94Acute necrotizing encephalopathy (HP:0006965)1.80476526
95Hypoplasia of the thymus (HP:0000778)1.79391856
96Pancreatic islet-cell hyperplasia (HP:0004510)1.77001378
97IgA deficiency (HP:0002720)1.76551417
98Cerebral edema (HP:0002181)1.76403786
99Adrenal hypoplasia (HP:0000835)1.75538028
100Arthropathy (HP:0003040)1.74469603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL24.18168485
2TRIM284.07608873
3EPHA34.03669577
4MAP3K124.02081891
5TLK13.72478651
6BMPR23.66732334
7ERBB32.74556700
8STK38L2.69078181
9GRK12.49722711
10VRK22.44610585
11TAOK32.35155215
12TRPM72.24917954
13GRK62.15045759
14GRK52.04767911
15MYLK2.02719053
16BCKDK1.92863151
17BLK1.72908157
18MAP2K21.66671579
19IKBKB1.66192038
20PINK11.66191500
21MAP3K41.60136365
22EIF2AK21.47695758
23FRK1.42812180
24KDR1.38879128
25DAPK21.36724407
26ZAK1.36258245
27ADRBK21.32221433
28VRK11.31646794
29DAPK11.26251200
30JAK11.21344506
31WNK31.16991001
32NEK61.10846675
33TAF11.08781241
34MAPK71.07380071
35EPHB11.06958665
36EPHA41.04682913
37PTK2B1.03657395
38CDK191.03001621
39BUB11.01722463
40STK240.99867499
41MAP2K70.95411439
42EIF2AK10.90949373
43EIF2AK30.86327313
44MKNK10.82969479
45CAMKK20.81845629
46INSRR0.79447527
47SYK0.76561997
48CHUK0.75772590
49TEC0.74800729
50TNK20.73609611
51MATK0.73125055
52TXK0.72730922
53CCNB10.72711218
54DAPK30.70809399
55ITK0.69347746
56FES0.68952338
57MAP3K140.64541427
58IRAK10.64233767
59ILK0.63658250
60CDK60.63591438
61ALK0.62031949
62MAP2K60.61265889
63AURKB0.58664542
64NEK20.57489856
65PIK3CG0.55185854
66MAP4K20.54215095
67MKNK20.52780507
68NTRK10.52141683
69BTK0.51763923
70FLT30.50662113
71FER0.49174120
72MAP3K60.49121822
73PLK40.47287782
74ARAF0.47023578
75PLK30.46984347
76DYRK20.46186072
77IKBKE0.46027533
78WNK40.44484608
79MST40.43192762
80OBSCN0.37230859
81PRKG20.37128342
82TBK10.33324548
83PKN10.32048813
84HCK0.30745260
85MAPK130.29400481
86STK390.28243960
87BMPR1B0.28069531
88OXSR10.27967640
89ERBB20.25653206
90PIM10.24725157
91SMG10.24605394
92PRKCE0.23690320
93TIE10.23479022
94MAPKAPK50.21132006
95MAP2K40.20358603
96NUAK10.19361051
97PLK20.18940248
98PRKCA0.17213746
99STK110.17128229
100MAPK150.16458373

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.75948690
2Oxidative phosphorylation_Homo sapiens_hsa001903.47608225
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.41887554
4Proteasome_Homo sapiens_hsa030503.24160664
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.20512637
6Parkinsons disease_Homo sapiens_hsa050122.98343718
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.50884773
8Ribosome_Homo sapiens_hsa030102.40710224
9Protein export_Homo sapiens_hsa030602.35937836
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.26523794
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.26073262
12Allograft rejection_Homo sapiens_hsa053302.16050130
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11043736
14Autoimmune thyroid disease_Homo sapiens_hsa053202.10251383
15Alzheimers disease_Homo sapiens_hsa050101.99624178
16Graft-versus-host disease_Homo sapiens_hsa053321.90590622
17Huntingtons disease_Homo sapiens_hsa050161.74468420
18Homologous recombination_Homo sapiens_hsa034401.73359188
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69179100
20Primary immunodeficiency_Homo sapiens_hsa053401.68351464
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68318036
22Base excision repair_Homo sapiens_hsa034101.64362392
23Propanoate metabolism_Homo sapiens_hsa006401.60537536
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.49180430
25Caffeine metabolism_Homo sapiens_hsa002321.46512050
26Type I diabetes mellitus_Homo sapiens_hsa049401.43590538
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41629133
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38915487
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32737032
30Phototransduction_Homo sapiens_hsa047441.27729562
31Rheumatoid arthritis_Homo sapiens_hsa053231.27157875
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.18864481
33Staphylococcus aureus infection_Homo sapiens_hsa051501.15324319
34Leishmaniasis_Homo sapiens_hsa051401.09096816
35Cardiac muscle contraction_Homo sapiens_hsa042601.07738043
36Antigen processing and presentation_Homo sapiens_hsa046121.07391781
37Non-homologous end-joining_Homo sapiens_hsa034501.00396060
38Nicotine addiction_Homo sapiens_hsa050330.97039357
39Maturity onset diabetes of the young_Homo sapiens_hsa049500.96365308
40Basal transcription factors_Homo sapiens_hsa030220.91627502
41Glycosaminoglycan degradation_Homo sapiens_hsa005310.90312219
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86919553
43Linoleic acid metabolism_Homo sapiens_hsa005910.85509915
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83965269
45Selenocompound metabolism_Homo sapiens_hsa004500.82357584
46Peroxisome_Homo sapiens_hsa041460.81500159
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.80103575
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.78276626
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77734039
50beta-Alanine metabolism_Homo sapiens_hsa004100.77727360
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75231849
52Viral myocarditis_Homo sapiens_hsa054160.72621151
53One carbon pool by folate_Homo sapiens_hsa006700.72152758
54RNA polymerase_Homo sapiens_hsa030200.71179789
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70396581
56Chemical carcinogenesis_Homo sapiens_hsa052040.64861283
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64734476
58Regulation of autophagy_Homo sapiens_hsa041400.63619805
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62905993
60Morphine addiction_Homo sapiens_hsa050320.62510805
61Shigellosis_Homo sapiens_hsa051310.61631142
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60735021
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59129938
64Systemic lupus erythematosus_Homo sapiens_hsa053220.58386520
65Taste transduction_Homo sapiens_hsa047420.53642769
66Toxoplasmosis_Homo sapiens_hsa051450.51601784
67Nucleotide excision repair_Homo sapiens_hsa034200.47959135
68Metabolic pathways_Homo sapiens_hsa011000.46498003
69Spliceosome_Homo sapiens_hsa030400.45717229
70Tuberculosis_Homo sapiens_hsa051520.44779889
71Butanoate metabolism_Homo sapiens_hsa006500.43661319
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43460191
73Serotonergic synapse_Homo sapiens_hsa047260.42962805
74Arachidonic acid metabolism_Homo sapiens_hsa005900.42550485
75Herpes simplex infection_Homo sapiens_hsa051680.42462273
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42184390
77Retinol metabolism_Homo sapiens_hsa008300.41353174
78Fat digestion and absorption_Homo sapiens_hsa049750.40327449
79Starch and sucrose metabolism_Homo sapiens_hsa005000.40106522
80Olfactory transduction_Homo sapiens_hsa047400.35070543
81Renin secretion_Homo sapiens_hsa049240.34696460
82Tryptophan metabolism_Homo sapiens_hsa003800.34367756
83Galactose metabolism_Homo sapiens_hsa000520.33215765
84T cell receptor signaling pathway_Homo sapiens_hsa046600.32817553
85Purine metabolism_Homo sapiens_hsa002300.31913680
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.30318619
87Fatty acid degradation_Homo sapiens_hsa000710.28091562
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27959787
89Tyrosine metabolism_Homo sapiens_hsa003500.27837017
90B cell receptor signaling pathway_Homo sapiens_hsa046620.26780285
91Collecting duct acid secretion_Homo sapiens_hsa049660.26113172
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25586079
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25312745
94GABAergic synapse_Homo sapiens_hsa047270.25201799
95Mismatch repair_Homo sapiens_hsa034300.23299291
96Arginine and proline metabolism_Homo sapiens_hsa003300.23165032
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23026173
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21660458
99Glutathione metabolism_Homo sapiens_hsa004800.19539467
100Histidine metabolism_Homo sapiens_hsa003400.17016563

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