HNRNPA1P74

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kynurenine metabolic process (GO:0070189)8.39837709
2tryptophan catabolic process (GO:0006569)7.10564882
3indole-containing compound catabolic process (GO:0042436)7.10564882
4indolalkylamine catabolic process (GO:0046218)7.10564882
5tryptophan metabolic process (GO:0006568)6.14058812
6amine catabolic process (GO:0009310)4.87437617
7cellular biogenic amine catabolic process (GO:0042402)4.87437617
8indolalkylamine metabolic process (GO:0006586)4.81537385
9DNA deamination (GO:0045006)4.78228874
10cellular response to exogenous dsRNA (GO:0071360)4.45917167
11rRNA modification (GO:0000154)4.27012948
12cytochrome complex assembly (GO:0017004)4.21767968
13organelle disassembly (GO:1903008)4.14437899
14GMP metabolic process (GO:0046037)4.12812994
15respiratory chain complex IV assembly (GO:0008535)4.07485620
16positive regulation of defense response to virus by host (GO:0002230)4.06677633
17piRNA metabolic process (GO:0034587)4.05036515
18negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.82685892
19rRNA methylation (GO:0031167)3.74309285
20metallo-sulfur cluster assembly (GO:0031163)3.61690364
21iron-sulfur cluster assembly (GO:0016226)3.61690364
22mitochondrial RNA metabolic process (GO:0000959)3.57456091
23negative regulation of T cell differentiation in thymus (GO:0033085)3.56253472
24L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.54950028
25protein deneddylation (GO:0000338)3.54947877
26aromatic amino acid family catabolic process (GO:0009074)3.52795678
27benzene-containing compound metabolic process (GO:0042537)3.49676003
28adenosine metabolic process (GO:0046085)3.46607700
29DNA double-strand break processing (GO:0000729)3.46094296
30regulation of chronic inflammatory response (GO:0002676)3.45607647
31protein complex biogenesis (GO:0070271)3.44049614
32cullin deneddylation (GO:0010388)3.41134259
33positive regulation of mitochondrial fission (GO:0090141)3.35541621
34interferon-gamma secretion (GO:0072643)3.34231810
35tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30877088
36RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30877088
37response to pheromone (GO:0019236)3.28572205
38L-methionine salvage (GO:0071267)3.28531205
39L-methionine biosynthetic process (GO:0071265)3.28531205
40amino acid salvage (GO:0043102)3.28531205
41regulation of defense response to virus by host (GO:0050691)3.27312700
42transcription from mitochondrial promoter (GO:0006390)3.23738823
43oxidative phosphorylation (GO:0006119)3.22833467
44mannosylation (GO:0097502)3.21816424
45regulation of thymocyte apoptotic process (GO:0070243)3.21622397
46mitochondrial respiratory chain complex assembly (GO:0033108)3.21335695
47indole-containing compound metabolic process (GO:0042430)3.19449550
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.17264151
49somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10052956
50somatic hypermutation of immunoglobulin genes (GO:0016446)3.10052956
51protein polyglutamylation (GO:0018095)3.04109275
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03968371
53methionine biosynthetic process (GO:0009086)3.03503256
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01095792
55regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.97108312
56DNA methylation involved in gamete generation (GO:0043046)2.91160612
57mitochondrial DNA replication (GO:0006264)2.88951581
58ubiquinone biosynthetic process (GO:0006744)2.86438622
59ribonucleoprotein complex disassembly (GO:0032988)2.85110670
60NAD biosynthetic process (GO:0009435)2.84113449
61pseudouridine synthesis (GO:0001522)2.82285020
62aggressive behavior (GO:0002118)2.82284698
63phosphatidylinositol acyl-chain remodeling (GO:0036149)2.81618250
64negative regulation of DNA-templated transcription, elongation (GO:0032785)2.81271844
65positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.81068203
66inositol phosphate dephosphorylation (GO:0046855)2.74198187
67phosphorylated carbohydrate dephosphorylation (GO:0046838)2.74198187
68chaperone-mediated protein transport (GO:0072321)2.73352264
69tRNA modification (GO:0006400)2.72928505
70non-recombinational repair (GO:0000726)2.72405498
71double-strand break repair via nonhomologous end joining (GO:0006303)2.72405498
72water-soluble vitamin biosynthetic process (GO:0042364)2.72203119
73behavioral response to nicotine (GO:0035095)2.71121327
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.69042813
75regulation of mitotic spindle checkpoint (GO:1903504)2.68501075
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68501075
77cellular response to dsRNA (GO:0071359)2.68147711
78somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67668816
79isotype switching (GO:0045190)2.67668816
80somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67668816
81positive regulation of mitotic sister chromatid separation (GO:1901970)2.67664274
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.67664274
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.67664274
84purine nucleobase biosynthetic process (GO:0009113)2.65588243
85ubiquinone metabolic process (GO:0006743)2.65556629
86purine nucleotide salvage (GO:0032261)2.63976942
87mitochondrial respiratory chain complex I assembly (GO:0032981)2.63814553
88NADH dehydrogenase complex assembly (GO:0010257)2.63814553
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.63814553
90protein K6-linked ubiquitination (GO:0085020)2.63745904
91positive regulation of prostaglandin secretion (GO:0032308)2.62974937
92histone H2A ubiquitination (GO:0033522)2.61674231
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61507928
94thrombin receptor signaling pathway (GO:0070493)2.61492286
95methionine metabolic process (GO:0006555)2.59734835
96S-adenosylmethionine metabolic process (GO:0046500)2.57462682
97regulation of germinal center formation (GO:0002634)2.54940973
98positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.54210819
99cellular response to ATP (GO:0071318)2.54204046
100peptidyl-histidine modification (GO:0018202)2.53033308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human4.85969344
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05800510
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.02346271
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.74606185
5ZNF274_21170338_ChIP-Seq_K562_Hela3.54486649
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.28639101
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99082174
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.83765315
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81953688
10SRF_21415370_ChIP-Seq_HL-1_Mouse2.57998563
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.53104916
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45240956
13VDR_22108803_ChIP-Seq_LS180_Human2.42521776
14VDR_23849224_ChIP-Seq_CD4+_Human2.37816567
15IGF1R_20145208_ChIP-Seq_DFB_Human2.19015714
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18435095
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08792076
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06271512
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.04201150
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99699061
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98854763
22FOXP3_21729870_ChIP-Seq_TREG_Human1.97054394
23ELK1_19687146_ChIP-ChIP_HELA_Human1.92810517
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91124073
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86908913
26GBX2_23144817_ChIP-Seq_PC3_Human1.86355288
27EWS_26573619_Chip-Seq_HEK293_Human1.84673116
28FUS_26573619_Chip-Seq_HEK293_Human1.83353025
29MYC_18940864_ChIP-ChIP_HL60_Human1.81247621
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78051650
31IRF1_19129219_ChIP-ChIP_H3396_Human1.75107138
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74456312
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71652604
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.67040405
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.61703013
36GATA3_26560356_Chip-Seq_TH2_Human1.58121708
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55246268
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54146896
39AR_20517297_ChIP-Seq_VCAP_Human1.51948969
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51641499
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50852949
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.50132835
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49684435
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39405556
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38249631
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35632907
47ER_23166858_ChIP-Seq_MCF-7_Human1.33697426
48TP53_22573176_ChIP-Seq_HFKS_Human1.33025874
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30886181
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30608915
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29135084
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28771573
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28754694
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.28754694
55MYB_26560356_Chip-Seq_TH2_Human1.27981167
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25540834
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23477392
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22665132
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22076931
60NANOG_19829295_ChIP-Seq_ESCs_Human1.21302056
61SOX2_19829295_ChIP-Seq_ESCs_Human1.21302056
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20711632
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19919659
64CBP_20019798_ChIP-Seq_JUKART_Human1.19919659
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18129120
66GABP_19822575_ChIP-Seq_HepG2_Human1.14801009
67CIITA_25753668_ChIP-Seq_RAJI_Human1.07853624
68TAF15_26573619_Chip-Seq_HEK293_Human1.07626069
69LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07136300
70HOXB7_26014856_ChIP-Seq_BT474_Human1.05209587
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05209574
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04879588
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03583792
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02918475
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02825404
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02005453
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01512033
78E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99303728
79NCOR_22424771_ChIP-Seq_293T_Human0.99289279
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99247282
81GATA3_26560356_Chip-Seq_TH1_Human0.99044634
82NFE2_27457419_Chip-Seq_LIVER_Mouse0.97698864
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97588504
84IRF8_21731497_ChIP-ChIP_J774_Mouse0.96236791
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91946286
86SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91482730
87GATA3_27048872_Chip-Seq_THYMUS_Human0.91400184
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90397065
89P300_19829295_ChIP-Seq_ESCs_Human0.90105182
90MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89926784
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89193688
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88439767
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87355813
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.84667556
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.84180955
96DCP1A_22483619_ChIP-Seq_HELA_Human0.82119773
97TTF2_22483619_ChIP-Seq_HELA_Human0.81746958
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81501053
99ERA_21632823_ChIP-Seq_H3396_Human0.81006305
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78917542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok4.84954946
2MP0006072_abnormal_retinal_apoptosis3.74908783
3MP0008877_abnormal_DNA_methylation3.69377846
4MP0008058_abnormal_DNA_repair3.07117407
5MP0003724_increased_susceptibility_to2.83477596
6MP0008775_abnormal_heart_ventricle2.60266449
7MP0003806_abnormal_nucleotide_metabolis2.20972202
8MP0002006_tumorigenesis2.15069778
9MP0003718_maternal_effect2.06175776
10MP0008872_abnormal_physiological_respon2.01991388
11MP0002166_altered_tumor_susceptibility2.00901659
12MP0002148_abnormal_hypersensitivity_rea1.98998077
13MP0005671_abnormal_response_to1.98065615
14MP0002138_abnormal_hepatobiliary_system1.97710432
15MP0001835_abnormal_antigen_presentation1.93198515
16MP0009764_decreased_sensitivity_to1.90610514
17MP0005084_abnormal_gallbladder_morpholo1.79202530
18MP0010094_abnormal_chromosome_stability1.73851288
19MP0000685_abnormal_immune_system1.71814654
20MP0005551_abnormal_eye_electrophysiolog1.70529918
21MP0005646_abnormal_pituitary_gland1.66628869
22MP0005253_abnormal_eye_physiology1.65644503
23MP0006036_abnormal_mitochondrial_physio1.60225964
24MP0001905_abnormal_dopamine_level1.54636754
25MP0006276_abnormal_autonomic_nervous1.53603251
26MP0002009_preneoplasia1.43835570
27MP0005389_reproductive_system_phenotype1.41274058
28MP0001501_abnormal_sleep_pattern1.39987552
29MP0005645_abnormal_hypothalamus_physiol1.39286701
30MP0004043_abnormal_pH_regulation1.38856922
31MP0002282_abnormal_trachea_morphology1.36869386
32MP0001986_abnormal_taste_sensitivity1.36470662
33MP0006292_abnormal_olfactory_placode1.34878709
34MP0003252_abnormal_bile_duct1.34808105
35MP0004147_increased_porphyrin_level1.32899006
36MP0000383_abnormal_hair_follicle1.30942242
37MP0004145_abnormal_muscle_electrophysio1.30316289
38MP0001968_abnormal_touch/_nociception1.30141121
39MP0005410_abnormal_fertilization1.25426527
40MP0003195_calcinosis1.23285019
41MP0003646_muscle_fatigue1.22712848
42MP0001293_anophthalmia1.22065712
43MP0004215_abnormal_myocardial_fiber1.18074887
44MP0001764_abnormal_homeostasis1.17934530
45MP0002160_abnormal_reproductive_system1.16109021
46MP0010386_abnormal_urinary_bladder1.15645481
47MP0004885_abnormal_endolymph1.15628034
48MP0001529_abnormal_vocalization1.15488669
49MP0002876_abnormal_thyroid_physiology1.15038922
50MP0002452_abnormal_antigen_presenting1.13736292
51MP0003693_abnormal_embryo_hatching1.12748502
52MP0010368_abnormal_lymphatic_system1.12642273
53MP0000230_abnormal_systemic_arterial1.12212667
54MP0001800_abnormal_humoral_immune1.11272017
55MP0001919_abnormal_reproductive_system1.09352269
56MP0002234_abnormal_pharynx_morphology1.08630230
57MP0002733_abnormal_thermal_nociception1.08247506
58MP0003186_abnormal_redox_activity1.08181666
59MP0005165_increased_susceptibility_to1.04421447
60MP0000689_abnormal_spleen_morphology1.04306671
61MP0004133_heterotaxia1.04170252
62MP0002102_abnormal_ear_morphology1.02376018
63MP0002723_abnormal_immune_serum1.01523777
64MP0003763_abnormal_thymus_physiology1.01006106
65MP0003880_abnormal_central_pattern1.00299923
66MP0005000_abnormal_immune_tolerance1.00272181
67MP0000372_irregular_coat_pigmentation0.99268708
68MP0003436_decreased_susceptibility_to0.96767812
69MP0001970_abnormal_pain_threshold0.95529869
70MP0009046_muscle_twitch0.93948024
71MP0001819_abnormal_immune_cell0.93444707
72MP0009765_abnormal_xenobiotic_induced0.90873757
73MP0002420_abnormal_adaptive_immunity0.89045427
74MP0009785_altered_susceptibility_to0.88609414
75MP0004142_abnormal_muscle_tone0.87281243
76MP0006035_abnormal_mitochondrial_morpho0.86442536
77MP0003786_premature_aging0.85357055
78MP0009745_abnormal_behavioral_response0.84795255
79MP0004084_abnormal_cardiac_muscle0.84493408
80MP0000427_abnormal_hair_cycle0.81682588
81MP0010678_abnormal_skin_adnexa0.81556296
82MP0002396_abnormal_hematopoietic_system0.81412751
83MP0002272_abnormal_nervous_system0.81376771
84MP0003866_abnormal_defecation0.81031927
85MP0005636_abnormal_mineral_homeostasis0.79271124
86MP0010155_abnormal_intestine_physiology0.79151057
87MP0001486_abnormal_startle_reflex0.76726706
88MP0000653_abnormal_sex_gland0.74814195
89MP0003011_delayed_dark_adaptation0.74530618
90MP0002837_dystrophic_cardiac_calcinosis0.74145272
91MP0001929_abnormal_gametogenesis0.73574577
92MP0003075_altered_response_to0.72154088
93MP0002722_abnormal_immune_system0.71221411
94MP0001845_abnormal_inflammatory_respons0.70186735
95MP0002638_abnormal_pupillary_reflex0.69562299
96MP0002751_abnormal_autonomic_nervous0.69140444
97MP0005167_abnormal_blood-brain_barrier0.68144119
98MP0005387_immune_system_phenotype0.67843378
99MP0001790_abnormal_immune_system0.67843378
100MP0004782_abnormal_surfactant_physiolog0.67622221

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the phalanges of the 2nd finger (HP:0009541)3.84664693
2Abnormality of the proximal phalanges of the hand (HP:0009834)3.72023567
3Lipid accumulation in hepatocytes (HP:0006561)3.59218607
4Hepatocellular necrosis (HP:0001404)3.59049229
5Prostate neoplasm (HP:0100787)3.51202940
6Abolished electroretinogram (ERG) (HP:0000550)3.37686314
7Abnormality of the prostate (HP:0008775)3.36361343
8Increased CSF lactate (HP:0002490)3.19510215
9Hepatic necrosis (HP:0002605)3.19361970
103-Methylglutaconic aciduria (HP:0003535)3.17038697
11Mitochondrial inheritance (HP:0001427)3.15031323
12Pancreatic cysts (HP:0001737)3.08609324
13Decreased electroretinogram (ERG) amplitude (HP:0000654)3.08164869
14Type 2 muscle fiber atrophy (HP:0003554)3.06070308
15Adactyly (HP:0009776)3.05057825
16Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.03456454
17Fibular aplasia (HP:0002990)3.02558887
18Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.01811433
19Increased hepatocellular lipid droplets (HP:0006565)2.86568616
20Pancreatic fibrosis (HP:0100732)2.86125776
21Elevated erythrocyte sedimentation rate (HP:0003565)2.80890824
22Abnormality of the phalanges of the 5th finger (HP:0004213)2.80056185
23Hypoplasia of the uterus (HP:0000013)2.75177098
24Increased serum lactate (HP:0002151)2.73829255
25Acute necrotizing encephalopathy (HP:0006965)2.72408726
26Abnormality of the middle phalanges of the toes (HP:0010183)2.72251568
27Decreased central vision (HP:0007663)2.64607752
28Opisthotonus (HP:0002179)2.62815713
29Methylmalonic acidemia (HP:0002912)2.61221399
30Muscle fiber atrophy (HP:0100295)2.59457094
31Aplasia/hypoplasia of the uterus (HP:0008684)2.57576690
32Progressive macrocephaly (HP:0004481)2.45502034
33Abnormal mitochondria in muscle tissue (HP:0008316)2.44148728
34Increased muscle lipid content (HP:0009058)2.39566892
35Lactic acidosis (HP:0003128)2.39544075
36Attenuation of retinal blood vessels (HP:0007843)2.38309548
37Congenital stationary night blindness (HP:0007642)2.37886285
38Symphalangism affecting the phalanges of the hand (HP:0009773)2.37376909
39Acute encephalopathy (HP:0006846)2.36920479
40Type II lissencephaly (HP:0007260)2.34898025
41Cerebellar dysplasia (HP:0007033)2.34611902
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34207826
43Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.33198155
44Spastic paraparesis (HP:0002313)2.31534959
45Abnormality of the renal cortex (HP:0011035)2.30626588
46Conjunctival hamartoma (HP:0100780)2.27113617
47Increased intramyocellular lipid droplets (HP:0012240)2.22590806
48Hyperglycinemia (HP:0002154)2.22020217
49Abnormal rod and cone electroretinograms (HP:0008323)2.20026414
50Hyperglycinuria (HP:0003108)2.18132261
51Abnormality of the pons (HP:0007361)2.17090655
52Nephronophthisis (HP:0000090)2.16316228
53Tubulointerstitial abnormality (HP:0001969)2.16191990
54Abnormality of male internal genitalia (HP:0000022)2.15681884
55Abnormality of alanine metabolism (HP:0010916)2.15656917
56Hyperalaninemia (HP:0003348)2.15656917
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15656917
58Cerebral edema (HP:0002181)2.13417816
59Progressive microcephaly (HP:0000253)2.13032094
60Methylmalonic aciduria (HP:0012120)2.12813234
61Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.11752700
62True hermaphroditism (HP:0010459)2.09916878
63Stomach cancer (HP:0012126)2.08744858
64Posterior subcapsular cataract (HP:0007787)2.06020564
65Progressive inability to walk (HP:0002505)2.05057172
66Congenital, generalized hypertrichosis (HP:0004540)2.03724368
67Tubulointerstitial fibrosis (HP:0005576)2.03183816
68Abnormality of the renal medulla (HP:0100957)2.02531595
69Hypoplasia of the pons (HP:0012110)2.00403786
70Renal cortical cysts (HP:0000803)1.98821428
71Absent/shortened dynein arms (HP:0200106)1.98069484
72Dynein arm defect of respiratory motile cilia (HP:0012255)1.98069484
73Aplasia/Hypoplasia of the hallux (HP:0008362)1.97752118
74Ketosis (HP:0001946)1.97179766
75Supernumerary spleens (HP:0009799)1.95665840
76Asplenia (HP:0001746)1.95155487
77Lethargy (HP:0001254)1.94101119
78Abnormality of the vitamin B12 metabolism (HP:0004341)1.93833902
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.93448965
80Abnormality of serine family amino acid metabolism (HP:0010894)1.93386794
81Abnormality of glycine metabolism (HP:0010895)1.93386794
82Renal Fanconi syndrome (HP:0001994)1.92590865
83Pendular nystagmus (HP:0012043)1.92043608
84Microvesicular hepatic steatosis (HP:0001414)1.90034234
85Abnormality of macular pigmentation (HP:0008002)1.89678915
86Polydipsia (HP:0001959)1.89363932
87Abnormal drinking behavior (HP:0030082)1.89363932
88Panhypogammaglobulinemia (HP:0003139)1.89006268
89CNS demyelination (HP:0007305)1.87300807
90Tubulointerstitial nephritis (HP:0001970)1.87096588
91Chronic otitis media (HP:0000389)1.85796822
92Abnormality of midbrain morphology (HP:0002418)1.84424005
93Molar tooth sign on MRI (HP:0002419)1.84424005
94Abnormality of the 2nd finger (HP:0004100)1.83348510
95Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83204392
96Dicarboxylic aciduria (HP:0003215)1.83204392
97Anhidrosis (HP:0000970)1.83178341
98Colon cancer (HP:0003003)1.82609928
99Emotional lability (HP:0000712)1.82198498
100Respiratory failure (HP:0002878)1.81883875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.33739817
2TAOK33.92165599
3ZAK3.53360854
4EIF2AK13.45158133
5EIF2AK33.24624324
6NUAK13.17768735
7VRK22.66079325
8MAP4K22.51174043
9FRK2.41160159
10BCKDK2.23782979
11MKNK12.14516807
12TLK12.14114911
13MAPKAPK31.94653112
14VRK11.90849731
15MST41.86158387
16TRIM281.78828346
17SRPK11.78041848
18MAPKAPK51.73241700
19PBK1.64532388
20NME21.61209348
21MAP3K141.60830629
22ADRBK21.59337532
23TAF11.55674982
24EIF2AK21.47370671
25FES1.45189688
26MAP3K41.45026064
27WNK41.39930300
28PLK31.37797967
29BMPR1B1.36378278
30TXK1.28431890
31TIE11.28178914
32CSNK1G31.24579789
33GRK11.22701847
34TEC1.21996434
35CSNK1A1L1.17804275
36PHKG21.13256236
37PHKG11.13256236
38DAPK11.08861647
39CAMKK21.05869362
40PINK11.04950336
41KIT1.01253186
42IRAK40.98274726
43ERBB30.95045469
44ITK0.92339501
45CSNK1G20.91703600
46PLK40.89725747
47IKBKB0.89092530
48FLT30.88988083
49PRKCQ0.86741124
50TBK10.86652712
51CSNK1G10.85982814
52MAP2K20.85194809
53GRK50.84702139
54NEK10.79829076
55OXSR10.76163948
56MATK0.74905527
57SYK0.74087109
58CSF1R0.66151874
59PLK20.65893357
60INSRR0.65305921
61MAP2K70.62057704
62BCR0.61806511
63WNK30.61684458
64RPS6KA50.61289779
65PASK0.58056865
66DYRK20.56394196
67STK390.55454319
68MAP4K10.52540215
69TNIK0.52453696
70ATR0.52190158
71BTK0.51373379
72IKBKE0.51149242
73LYN0.50287423
74CDK190.47128549
75TNK20.45929900
76GRK60.45571777
77KDR0.42114750
78EPHA30.41489458
79PIK3CA0.40845670
80ADRBK10.40357688
81NEK60.40046288
82MAPK130.39824212
83LCK0.39273512
84STK38L0.37912390
85CHEK20.35187721
86CDC70.33626934
87PAK60.33040304
88TGFBR10.32500436
89ABL10.31881513
90RPS6KB20.31619376
91CAMKK10.31563825
92CSNK1A10.30430715
93PLK10.28413581
94NEK90.27969131
95TSSK60.27896673
96PRKCE0.27632540
97IGF1R0.26253723
98MAPK70.25270183
99HCK0.25196336
100PTK2B0.24672821

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002328.38977862
2Asthma_Homo sapiens_hsa053103.05788820
3Proteasome_Homo sapiens_hsa030502.63133402
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.30647028
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30199642
6One carbon pool by folate_Homo sapiens_hsa006701.85704055
7Tryptophan metabolism_Homo sapiens_hsa003801.85439002
8Allograft rejection_Homo sapiens_hsa053301.84563902
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72717128
10Linoleic acid metabolism_Homo sapiens_hsa005911.70813322
11Autoimmune thyroid disease_Homo sapiens_hsa053201.69926947
12Type I diabetes mellitus_Homo sapiens_hsa049401.58227808
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57139659
14Protein export_Homo sapiens_hsa030601.55649528
15Oxidative phosphorylation_Homo sapiens_hsa001901.55496408
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51948466
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49810286
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.49802897
19Propanoate metabolism_Homo sapiens_hsa006401.45003916
20Parkinsons disease_Homo sapiens_hsa050121.42667981
21Fanconi anemia pathway_Homo sapiens_hsa034601.39695162
22Graft-versus-host disease_Homo sapiens_hsa053321.37406963
23Phototransduction_Homo sapiens_hsa047441.34831319
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.33822461
25Non-homologous end-joining_Homo sapiens_hsa034501.25380821
26Mismatch repair_Homo sapiens_hsa034301.24251334
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21912931
28RNA degradation_Homo sapiens_hsa030181.19673013
29Ether lipid metabolism_Homo sapiens_hsa005651.16450388
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15288871
31Arachidonic acid metabolism_Homo sapiens_hsa005901.14568171
32Spliceosome_Homo sapiens_hsa030401.13358882
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12134606
34Nitrogen metabolism_Homo sapiens_hsa009101.11871768
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07886051
36RNA polymerase_Homo sapiens_hsa030201.06351460
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04199316
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03332252
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02423591
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.01594094
41Homologous recombination_Homo sapiens_hsa034400.99713114
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99165014
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96395039
44Ribosome_Homo sapiens_hsa030100.95529866
45Nucleotide excision repair_Homo sapiens_hsa034200.94994038
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94051602
47Fatty acid elongation_Homo sapiens_hsa000620.94024866
48Purine metabolism_Homo sapiens_hsa002300.93441059
49RNA transport_Homo sapiens_hsa030130.93416891
50Peroxisome_Homo sapiens_hsa041460.93344379
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92688011
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91634059
53Rheumatoid arthritis_Homo sapiens_hsa053230.91382743
54Basal transcription factors_Homo sapiens_hsa030220.88292734
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.81873553
56Chemical carcinogenesis_Homo sapiens_hsa052040.81843996
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81843458
58DNA replication_Homo sapiens_hsa030300.80868242
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80484690
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79898549
61Primary immunodeficiency_Homo sapiens_hsa053400.79622245
62Base excision repair_Homo sapiens_hsa034100.73944043
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73341362
64Herpes simplex infection_Homo sapiens_hsa051680.72259165
65Ovarian steroidogenesis_Homo sapiens_hsa049130.72162479
66Sulfur metabolism_Homo sapiens_hsa009200.71610683
67Hematopoietic cell lineage_Homo sapiens_hsa046400.69370901
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67219567
69Antigen processing and presentation_Homo sapiens_hsa046120.63551071
70Salivary secretion_Homo sapiens_hsa049700.63023292
71Alzheimers disease_Homo sapiens_hsa050100.62873649
72Olfactory transduction_Homo sapiens_hsa047400.61127100
73Huntingtons disease_Homo sapiens_hsa050160.59690541
74Staphylococcus aureus infection_Homo sapiens_hsa051500.57625330
75Leishmaniasis_Homo sapiens_hsa051400.57294369
76Taste transduction_Homo sapiens_hsa047420.53596940
77Metabolic pathways_Homo sapiens_hsa011000.52411050
78Systemic lupus erythematosus_Homo sapiens_hsa053220.50978832
79Morphine addiction_Homo sapiens_hsa050320.50066009
80Retinol metabolism_Homo sapiens_hsa008300.48407427
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.47466217
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44642666
83Pyrimidine metabolism_Homo sapiens_hsa002400.44297295
84Butanoate metabolism_Homo sapiens_hsa006500.44233487
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42210098
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39887414
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38419648
88Carbon metabolism_Homo sapiens_hsa012000.37459345
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37301933
90Circadian entrainment_Homo sapiens_hsa047130.36367724
91Biosynthesis of amino acids_Homo sapiens_hsa012300.35352829
92Serotonergic synapse_Homo sapiens_hsa047260.34111559
93Nicotine addiction_Homo sapiens_hsa050330.33836900
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32402153
95p53 signaling pathway_Homo sapiens_hsa041150.31112402
96Renin secretion_Homo sapiens_hsa049240.29514505
97Fat digestion and absorption_Homo sapiens_hsa049750.28216027
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26868121
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.25655015
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23534242

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