ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of DNA methylation (GO:0044030)	8.49481645
2	regulation of female gonad development (GO:2000194)	8.39574479
3	regulation of acrosome reaction (GO:0060046)	7.80428112
4	piRNA metabolic process (GO:0034587)	7.65039369
5	meiotic cell cycle (GO:0051321)	6.98830007
6	positive regulation of histone H3-K4 methylation (GO:0051571)	6.75842021
7	retinal cone cell development (GO:0046549)	6.61239567
8	multicellular organism reproduction (GO:0032504)	6.42881488
9	regulation of meiosis I (GO:0060631)	5.92326394
10	DNA methylation involved in gamete generation (GO:0043046)	5.74741193
11	regulation of histone H3-K9 methylation (GO:0051570)	5.21497751
12	protein kinase C signaling (GO:0070528)	5.12548676
13	positive regulation of humoral immune response (GO:0002922)	5.06887407
14	oocyte development (GO:0048599)	4.90030125
15	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.89721400
16	negative regulation of reproductive process (GO:2000242)	4.89289844
17	glycine transport (GO:0015816)	4.88844259
18	female gamete generation (GO:0007292)	4.73266376
19	regulation of retinoic acid receptor signaling pathway (GO:0048385)	4.52401781
20	gene silencing by RNA (GO:0031047)	4.44751916
21	regulation of steroid hormone secretion (GO:2000831)	4.42459384
22	synapsis (GO:0007129)	4.41014667
23	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.37398556
24	attachment of spindle microtubules to kinetochore (GO:0008608)	4.30526058
25	DNA replication-dependent nucleosome assembly (GO:0006335)	4.26561189
26	DNA replication-dependent nucleosome organization (GO:0034723)	4.26561189
27	reproduction (GO:0000003)	4.14775425
28	centriole replication (GO:0007099)	4.13938762
29	CENP-A containing nucleosome assembly (GO:0034080)	4.08327524
30	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.04364414
31	protein localization to kinetochore (GO:0034501)	4.02644868
32	mitotic metaphase plate congression (GO:0007080)	3.97310561
33	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.90375231
34	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.90375231
35	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.90375231
36	binding of sperm to zona pellucida (GO:0007339)	3.88454437
37	positive regulation of histone methylation (GO:0031062)	3.84136100
38	regulation of cell maturation (GO:1903429)	3.80303866
39	chromatin remodeling at centromere (GO:0031055)	3.79736369
40	mitotic chromosome condensation (GO:0007076)	3.77949709
41	male meiosis I (GO:0007141)	3.75385569
42	proteasome assembly (GO:0043248)	3.74522414
43	negative regulation of histone methylation (GO:0031061)	3.73559792
44	positive regulation of gastrulation (GO:2000543)	3.68867629
45	protein localization to chromosome, centromeric region (GO:0071459)	3.67331597
46	negative regulation of execution phase of apoptosis (GO:1900118)	3.60408793
47	DNA replication checkpoint (GO:0000076)	3.58011765
48	male meiosis (GO:0007140)	3.56547972
49	establishment of chromosome localization (GO:0051303)	3.50840130
50	positive regulation of chromosome segregation (GO:0051984)	3.50412243
51	positive regulation of reproductive process (GO:2000243)	3.50280473
52	regulation of histone H3-K4 methylation (GO:0051569)	3.44564951
53	single fertilization (GO:0007338)	3.43319757
54	aggressive behavior (GO:0002118)	3.41557837
55	meiosis I (GO:0007127)	3.39555895
56	metaphase plate congression (GO:0051310)	3.38259806
57	fertilization (GO:0009566)	3.35075094
58	sperm-egg recognition (GO:0035036)	3.34557702
59	histone exchange (GO:0043486)	3.29619686
60	base-excision repair, AP site formation (GO:0006285)	3.28576424
61	DNA deamination (GO:0045006)	3.27715648
62	phosphorelay signal transduction system (GO:0000160)	3.23074979
63	translesion synthesis (GO:0019985)	3.16244924
64	protein deneddylation (GO:0000338)	3.15382161
65	cullin deneddylation (GO:0010388)	3.15370674
66	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.13971408
67	regulation of spindle checkpoint (GO:0090231)	3.13722115
68	regulation of meiosis (GO:0040020)	3.10762963
69	meiotic nuclear division (GO:0007126)	3.05738472
70	DNA alkylation (GO:0006305)	3.02489592
71	DNA methylation (GO:0006306)	3.02489592
72	DNA replication-independent nucleosome organization (GO:0034724)	2.99385133
73	DNA replication-independent nucleosome assembly (GO:0006336)	2.99385133
74	primitive streak formation (GO:0090009)	2.98732548
75	regulation of mitotic spindle checkpoint (GO:1903504)	2.98203044
76	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.98203044
77	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.96109352
78	hyperosmotic salinity response (GO:0042538)	2.92029856
79	protein localization to chromosome (GO:0034502)	2.91841410
80	chromosome organization involved in meiosis (GO:0070192)	2.91669587
81	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.91473642
82	regulation of reproductive process (GO:2000241)	2.91437920
83	postreplication repair (GO:0006301)	2.90578122
84	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.89407396
85	regulation of steroid hormone biosynthetic process (GO:0090030)	2.88924853
86	regulation of spindle organization (GO:0090224)	2.84455900
87	gene silencing (GO:0016458)	2.84390816
88	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.83240728
89	DNA modification (GO:0006304)	2.83119239
90	meiotic cell cycle process (GO:1903046)	2.81900806
91	regulation of uterine smooth muscle contraction (GO:0070472)	2.80339805
92	chromatin assembly (GO:0031497)	2.80015794
93	citrulline biosynthetic process (GO:0019240)	2.79099823
94	regulation of histone methylation (GO:0031060)	2.78895824
95	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.76209111
96	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.74369203
97	DNA methylation or demethylation (GO:0044728)	2.74202971
98	regulation of chromatin silencing (GO:0031935)	2.74004764
99	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.72786144
100	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.70259921

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.51467335
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.52912240
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.49725229
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.49629595
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.23105925
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.93009206
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.72247696
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.49433527
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.45181828
10	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.43506990
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.34232341
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.25932409
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.20354469
14	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.18094980
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.13279660
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.09813065
17	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.09594770
18	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.02132399
19	EZH2_22144423_ChIP-Seq_EOC_Human	10.9461772
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.97359603
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.93736547
22	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.93096298
23	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.93096298
24	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.93096298
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.91100720
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.78334661
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77222496
28	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.76847449
29	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.76004176
30	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.70572613
31	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.69942402
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.64069693
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.63067826
34	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.61857467
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.47809644
36	EWS_26573619_Chip-Seq_HEK293_Human	1.43676054
37	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.40458166
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.39460985
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.38293364
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33809305
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.33809305
42	GBX2_23144817_ChIP-Seq_PC3_Human	1.33701120
43	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.33381897
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30911422
45	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.26238977
46	VDR_22108803_ChIP-Seq_LS180_Human	1.24452837
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22480973
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.21112026
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20191315
50	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.17542238
51	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.16849080
52	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08727925
53	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.06678863
54	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.06163936
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05537541
56	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03526541
57	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00528726
58	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.97600088
59	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.97388103
60	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97306011
61	P300_19829295_ChIP-Seq_ESCs_Human	0.95871517
62	GABP_19822575_ChIP-Seq_HepG2_Human	0.95174614
63	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.94913269
64	AR_20517297_ChIP-Seq_VCAP_Human	0.94591975
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.94125938
66	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.93139343
67	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.92077300
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91871342
69	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.91811297
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.89082134
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.89082134
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.89013305
73	DCP1A_22483619_ChIP-Seq_HELA_Human	0.88239601
74	TCF4_23295773_ChIP-Seq_U87_Human	0.88117622
75	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.88032314
76	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.87507115
77	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.85940800
78	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.85588384
79	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.85417336
80	NANOG_19829295_ChIP-Seq_ESCs_Human	0.85337832
81	SOX2_19829295_ChIP-Seq_ESCs_Human	0.85337832
82	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.84718060
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.84506061
84	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.83990581
85	NCOR_22424771_ChIP-Seq_293T_Human	0.83961237
86	FUS_26573619_Chip-Seq_HEK293_Human	0.83783898
87	AR_25329375_ChIP-Seq_VCAP_Human	0.83726614
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.82676798
89	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.81695445
90	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.81033493
91	CBP_21632823_ChIP-Seq_H3396_Human	0.78401187
92	GATA3_26560356_Chip-Seq_TH1_Human	0.78119874
93	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.77591326
94	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.77033872
95	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.77012518
96	ERG_20517297_ChIP-Seq_VCAP_Human	0.75666021
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.75014652
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.74503736
99	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.74032466
100	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.73979699

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	7.42850188
2	MP0006292_abnormal_olfactory_placode	4.96969058
3	MP0008877_abnormal_DNA_methylation	4.58240890
4	MP0008789_abnormal_olfactory_epithelium	3.98559358
5	MP0003693_abnormal_embryo_hatching	3.55978058
6	MP0005499_abnormal_olfactory_system	3.44909926
7	MP0005394_taste/olfaction_phenotype	3.44909926
8	MP0005395_other_phenotype	2.82767590
9	MP0002234_abnormal_pharynx_morphology	2.77438084
10	MP0008058_abnormal_DNA_repair	2.71701510
11	MP0002139_abnormal_hepatobiliary_system	2.59201243
12	MP0002138_abnormal_hepatobiliary_system	2.52447683
13	MP0003890_abnormal_embryonic-extraembry	2.48723332
14	MP0008057_abnormal_DNA_replication	2.39156355
15	MP0010094_abnormal_chromosome_stability	2.36701549
16	MP0001929_abnormal_gametogenesis	2.15619032
17	MP0003699_abnormal_female_reproductive	2.13885026
18	MP0003077_abnormal_cell_cycle	2.01431222
19	MP0002210_abnormal_sex_determination	2.01096763
20	MP0005360_urolithiasis	1.94155207
21	MP0001293_anophthalmia	1.93947802
22	MP0003111_abnormal_nucleus_morphology	1.91932402
23	MP0005646_abnormal_pituitary_gland	1.79639112
24	MP0005410_abnormal_fertilization	1.68346611
25	MP0000653_abnormal_sex_gland	1.63935877
26	MP0002160_abnormal_reproductive_system	1.50602666
27	MP0010030_abnormal_orbit_morphology	1.49375446
28	MP0008932_abnormal_embryonic_tissue	1.47953111
29	MP0001119_abnormal_female_reproductive	1.47933160
30	MP0002161_abnormal_fertility/fecundity	1.47101143
31	MP0000631_abnormal_neuroendocrine_gland	1.44247141
32	MP0001984_abnormal_olfaction	1.42558814
33	MP0004957_abnormal_blastocyst_morpholog	1.40336003
34	MP0005389_reproductive_system_phenotype	1.38649827
35	MP0008875_abnormal_xenobiotic_pharmacok	1.32446959
36	MP0004142_abnormal_muscle_tone	1.30652858
37	MP0002102_abnormal_ear_morphology	1.28958236
38	MP0003786_premature_aging	1.28330071
39	MP0006276_abnormal_autonomic_nervous	1.28254890
40	MP0003879_abnormal_hair_cell	1.28240409
41	MP0003252_abnormal_bile_duct	1.26868275
42	MP0001145_abnormal_male_reproductive	1.26681476
43	MP0001730_embryonic_growth_arrest	1.25264007
44	MP0003121_genomic_imprinting	1.20138009
45	MP0005551_abnormal_eye_electrophysiolog	1.19725310
46	MP0000372_irregular_coat_pigmentation	1.17754720
47	MP0005075_abnormal_melanosome_morpholog	1.16604563
48	MP0008995_early_reproductive_senescence	1.13192736
49	MP0006072_abnormal_retinal_apoptosis	1.11992482
50	MP0003698_abnormal_male_reproductive	1.11279170
51	MP0010307_abnormal_tumor_latency	1.11253159
52	MP0003950_abnormal_plasma_membrane	1.08518026
53	MP0002233_abnormal_nose_morphology	1.08350025
54	MP0005085_abnormal_gallbladder_physiolo	1.07487076
55	MP0003183_abnormal_peptide_metabolism	1.05373826
56	MP0000427_abnormal_hair_cycle	1.01516466
57	MP0005647_abnormal_sex_gland	1.00669704
58	MP0003119_abnormal_digestive_system	0.99990576
59	MP0002272_abnormal_nervous_system	0.97194298
60	MP0000049_abnormal_middle_ear	0.94730548
61	MP0010368_abnormal_lymphatic_system	0.91833877
62	MP0000566_synostosis	0.91201145
63	MP0001919_abnormal_reproductive_system	0.85089278
64	MP0009379_abnormal_foot_pigmentation	0.83322977
65	MP0002751_abnormal_autonomic_nervous	0.82447997
66	MP0001764_abnormal_homeostasis	0.81758050
67	MP0003195_calcinosis	0.79722071
68	MP0001986_abnormal_taste_sensitivity	0.77905569
69	MP0001664_abnormal_digestion	0.77283969
70	MP0005380_embryogenesis_phenotype	0.76392435
71	MP0001672_abnormal_embryogenesis/_devel	0.76392435
72	MP0003567_abnormal_fetal_cardiomyocyte	0.71513208
73	MP0010234_abnormal_vibrissa_follicle	0.70533881
74	MP0001666_abnormal_nutrient_absorption	0.69600188
75	MP0002095_abnormal_skin_pigmentation	0.69402270
76	MP0002163_abnormal_gland_morphology	0.68989907
77	MP0000350_abnormal_cell_proliferation	0.68343362
78	MP0001324_abnormal_eye_pigmentation	0.67435166
79	MP0005253_abnormal_eye_physiology	0.66369742
80	MP0001529_abnormal_vocalization	0.63804431
81	MP0005645_abnormal_hypothalamus_physiol	0.62604210
82	MP0001502_abnormal_circadian_rhythm	0.62037867
83	MP0005671_abnormal_response_to	0.61700845
84	MP0002019_abnormal_tumor_incidence	0.59673552
85	MP0003186_abnormal_redox_activity	0.57450062
86	MP0005319_abnormal_enzyme/_coenzyme	0.56718596
87	MP0001881_abnormal_mammary_gland	0.56465980
88	MP0000762_abnormal_tongue_morphology	0.56264602
89	MP0004145_abnormal_muscle_electrophysio	0.55478826
90	MP0003880_abnormal_central_pattern	0.54703111
91	MP0001963_abnormal_hearing_physiology	0.53176754
92	MP0001905_abnormal_dopamine_level	0.50054290
93	MP0004043_abnormal_pH_regulation	0.47707258
94	MP0005391_vision/eye_phenotype	0.46694896
95	MP0000313_abnormal_cell_death	0.46029334
96	MP0002084_abnormal_developmental_patter	0.43221285
97	MP0006036_abnormal_mitochondrial_physio	0.42988028
98	MP0009333_abnormal_splenocyte_physiolog	0.42061544
99	MP0000647_abnormal_sebaceous_gland	0.42013828
100	MP0003959_abnormal_lean_body	0.41604239

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Supernumerary spleens (HP:0009799)	4.58836129
2	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.38814292
3	Abnormality of abdominal situs (HP:0011620)	4.33632160
4	Abdominal situs inversus (HP:0003363)	4.33632160
5	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.03907179
6	Hypoplasia of the fovea (HP:0007750)	4.03907179
7	Impulsivity (HP:0100710)	3.99058754
8	Anterior segment dysgenesis (HP:0007700)	3.77589529
9	Male infertility (HP:0003251)	3.70662798
10	Abnormality of the fovea (HP:0000493)	3.53697451
11	Facial hemangioma (HP:0000329)	3.49282158
12	Hypophosphatemic rickets (HP:0004912)	3.42877723
13	Cholecystitis (HP:0001082)	3.42023178
14	Abnormal gallbladder physiology (HP:0012438)	3.42023178
15	Abnormality of the labia minora (HP:0012880)	3.40266168
16	Septo-optic dysplasia (HP:0100842)	3.22845569
17	Short tibia (HP:0005736)	3.18779668
18	Gonadotropin excess (HP:0000837)	3.15159228
19	Oligodactyly (hands) (HP:0001180)	3.05080279
20	Azoospermia (HP:0000027)	3.00775998
21	Osteomalacia (HP:0002749)	3.00211225
22	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.99487147
23	Chromsome breakage (HP:0040012)	2.95663226
24	Abnormality of midbrain morphology (HP:0002418)	2.93757118
25	Molar tooth sign on MRI (HP:0002419)	2.93757118
26	Median cleft lip (HP:0000161)	2.92461510
27	Posterior subcapsular cataract (HP:0007787)	2.92158026
28	Lip pit (HP:0100267)	2.84653530
29	Infertility (HP:0000789)	2.80940620
30	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.79570717
31	Aplastic anemia (HP:0001915)	2.76196482
32	Abnormal spermatogenesis (HP:0008669)	2.73627691
33	Absent septum pellucidum (HP:0001331)	2.68966223
34	Bile duct proliferation (HP:0001408)	2.67785878
35	Abnormal biliary tract physiology (HP:0012439)	2.67785878
36	Hypokinesia (HP:0002375)	2.64884702
37	Methylmalonic acidemia (HP:0002912)	2.60502928
38	Generalized aminoaciduria (HP:0002909)	2.59948928
39	Papillary thyroid carcinoma (HP:0002895)	2.52990724
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.49681364
41	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.42051054
42	Aplasia/Hypoplasia of the macula (HP:0008059)	2.39949443
43	Premature ovarian failure (HP:0008209)	2.37745767
44	Pancreatic cysts (HP:0001737)	2.37086353
45	Oligodactyly (HP:0012165)	2.36796315
46	Meckel diverticulum (HP:0002245)	2.36391881
47	Attenuation of retinal blood vessels (HP:0007843)	2.33912319
48	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.33827238
49	Abnormality of the ileum (HP:0001549)	2.31783321
50	Abnormality of the septum pellucidum (HP:0007375)	2.29810675
51	Colon cancer (HP:0003003)	2.20858877
52	Hypoplasia of the uterus (HP:0000013)	2.20855838
53	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.19381480
54	Abnormal lung lobation (HP:0002101)	2.19159320
55	Capillary hemangiomas (HP:0005306)	2.13171900
56	Renal cortical cysts (HP:0000803)	2.12072221
57	Abnormality of the preputium (HP:0100587)	2.10770769
58	Aplasia/hypoplasia of the uterus (HP:0008684)	2.10325678
59	Abnormal ciliary motility (HP:0012262)	2.01995384
60	Broad alveolar ridges (HP:0000187)	1.98254479
61	Small intestinal stenosis (HP:0012848)	1.97828647
62	Duodenal stenosis (HP:0100867)	1.97828647
63	Anhidrosis (HP:0000970)	1.95868792
64	Diminished motivation (HP:0000745)	1.95489590
65	Apathy (HP:0000741)	1.95103477
66	Abnormality of DNA repair (HP:0003254)	1.95000728
67	Pancreatic fibrosis (HP:0100732)	1.94263546
68	Abnormality of chromosome stability (HP:0003220)	1.92712532
69	Abnormality of the alveolar ridges (HP:0006477)	1.92189132
70	Cleft eyelid (HP:0000625)	1.90847741
71	Thyroid-stimulating hormone excess (HP:0002925)	1.88740927
72	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.86563402
73	Abnormal respiratory motile cilium physiology (HP:0012261)	1.85966963
74	Degeneration of anterior horn cells (HP:0002398)	1.85454355
75	Abnormality of the anterior horn cell (HP:0006802)	1.85454355
76	3-Methylglutaconic aciduria (HP:0003535)	1.85302859
77	Proximal tubulopathy (HP:0000114)	1.83748435
78	Decreased central vision (HP:0007663)	1.81371331
79	Pendular nystagmus (HP:0012043)	1.80191173
80	Carpal bone hypoplasia (HP:0001498)	1.78504662
81	Sensory axonal neuropathy (HP:0003390)	1.78072482
82	Methylmalonic aciduria (HP:0012120)	1.77566279
83	Hypergonadotropic hypogonadism (HP:0000815)	1.76422331
84	Preaxial hand polydactyly (HP:0001177)	1.76225465
85	Bifid tongue (HP:0010297)	1.76131187
86	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.75829217
87	Congenital sensorineural hearing impairment (HP:0008527)	1.73570854
88	Metaphyseal irregularity (HP:0003025)	1.73141809
89	Hyperglycinemia (HP:0002154)	1.73037673
90	Horseshoe kidney (HP:0000085)	1.72939301
91	Clubbing of toes (HP:0100760)	1.72699305
92	Dysdiadochokinesis (HP:0002075)	1.72615674
93	Chronic hepatic failure (HP:0100626)	1.71490238
94	Aplasia of the musculature (HP:0100854)	1.70968325
95	Thyroid carcinoma (HP:0002890)	1.70965171
96	Nausea (HP:0002018)	1.69869843
97	Nephroblastoma (Wilms tumor) (HP:0002667)	1.69699400
98	Limb hypertonia (HP:0002509)	1.69200946
99	Abnormality of the renal cortex (HP:0011035)	1.69130052
100	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.68602014

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	3.58591208
2	ARAF	3.37750494
3	TAOK3	3.16210077
4	MAP3K13	3.15446291
5	MAP4K2	2.96915942
6	BUB1	2.91737899
7	ZAK	2.89057301
8	EIF2AK3	2.75662504
9	NEK6	2.62526700
10	TRIM28	2.60626254
11	CDC7	2.34529581
12	TTK	2.27257048
13	SRPK1	2.26573750
14	CDK19	2.22658864
15	NUAK1	2.19254459
16	MST4	2.12500177
17	AURKA	2.09948319
18	TLK1	1.84952976
19	TXK	1.73305151
20	VRK1	1.72245945
21	BRAF	1.64617667
22	STK24	1.56055930
23	BCKDK	1.54341416
24	PLK3	1.52903156
25	PLK1	1.50381582
26	VRK2	1.50250274
27	CDK9	1.49473223
28	MOS	1.42630988
29	TESK2	1.37677945
30	TIE1	1.31158046
31	PRKCI	1.28112198
32	CDK7	1.27993730
33	CSNK1G1	1.26322343
34	CSNK1G3	1.26010282
35	PBK	1.25154371
36	KDR	1.18024174
37	BMPR1B	1.13405812
38	TSSK6	1.11297871
39	BRSK1	1.10100284
40	BRSK2	1.05238713
41	EIF2AK1	1.03641389
42	CSNK1A1L	1.03406100
43	NTRK2	0.96049620
44	AURKB	0.93459170
45	CDK8	0.91525909
46	OXSR1	0.90443607
47	CSNK1G2	0.90050700
48	MET	0.89707100
49	ATR	0.87773831
50	TNK2	0.87132089
51	RAF1	0.85861277
52	TNIK	0.85584127
53	CHEK1	0.83964997
54	STK39	0.81062931
55	CHEK2	0.80951551
56	NEK2	0.79297427
57	PLK4	0.75577703
58	MELK	0.74694530
59	TGFBR1	0.74181636
60	WNK4	0.73184253
61	WNK3	0.72599760
62	MAPK13	0.72039941
63	MAP3K4	0.71128588
64	ATM	0.70883078
65	STK16	0.66574370
66	PIM1	0.61310685
67	STK3	0.60656524
68	CDK2	0.60294229
69	NEK1	0.59392487
70	EIF2AK2	0.57992920
71	ADRBK2	0.55783831
72	PAK1	0.54597550
73	CSNK1D	0.54584447
74	NME1	0.48254967
75	NEK9	0.47570441
76	CSNK1E	0.46472874
77	GRK1	0.44315814
78	MAP3K5	0.42714506
79	MKNK1	0.42505024
80	PINK1	0.42252576
81	MAP2K7	0.41383496
82	PRKG1	0.41367163
83	CDK1	0.41357795
84	ITK	0.41129565
85	MAP3K8	0.40544333
86	MAPKAPK3	0.38423120
87	PKN1	0.36396606
88	CDK12	0.35368512
89	KSR2	0.35318887
90	DAPK1	0.33132889
91	PRKACA	0.33046115
92	MARK3	0.32983761
93	KSR1	0.32390242
94	CSNK2A1	0.30436706
95	CSNK2A2	0.30392440
96	EPHA4	0.28649494
97	CAMK2A	0.28392336
98	PRKACB	0.27498684
99	PRKCQ	0.27064682
100	WNK1	0.25995237

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	4.45506826
2	Caffeine metabolism_Homo sapiens_hsa00232	3.74155019
3	Mismatch repair_Homo sapiens_hsa03430	3.41467279
4	Proteasome_Homo sapiens_hsa03050	3.19195550
5	Base excision repair_Homo sapiens_hsa03410	2.87682209
6	RNA degradation_Homo sapiens_hsa03018	2.85720743
7	Cell cycle_Homo sapiens_hsa04110	2.82462422
8	DNA replication_Homo sapiens_hsa03030	2.66908509
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.64268764
10	Nucleotide excision repair_Homo sapiens_hsa03420	2.63200344
11	RNA polymerase_Homo sapiens_hsa03020	2.59973759
12	RNA transport_Homo sapiens_hsa03013	2.26418648
13	Homologous recombination_Homo sapiens_hsa03440	2.20739643
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.13442833
15	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.13377626
16	Oocyte meiosis_Homo sapiens_hsa04114	2.08267402
17	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.07246236
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.03592166
19	Phototransduction_Homo sapiens_hsa04744	1.78522304
20	Spliceosome_Homo sapiens_hsa03040	1.71603607
21	Protein export_Homo sapiens_hsa03060	1.64366322
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.56551786
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.54746607
24	Oxidative phosphorylation_Homo sapiens_hsa00190	1.52623678
25	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.45376711
26	Parkinsons disease_Homo sapiens_hsa05012	1.43311713
27	Olfactory transduction_Homo sapiens_hsa04740	1.41258366
28	Propanoate metabolism_Homo sapiens_hsa00640	1.39700788
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.31359883
30	Huntingtons disease_Homo sapiens_hsa05016	1.28824207
31	Purine metabolism_Homo sapiens_hsa00230	1.19942569
32	p53 signaling pathway_Homo sapiens_hsa04115	1.17150713
33	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.16208896
34	mRNA surveillance pathway_Homo sapiens_hsa03015	1.15911937
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.11254302
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.11209499
37	Ribosome_Homo sapiens_hsa03010	1.10191884
38	Fatty acid elongation_Homo sapiens_hsa00062	1.08834343
39	Asthma_Homo sapiens_hsa05310	1.07559668
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.07353353
41	Folate biosynthesis_Homo sapiens_hsa00790	1.03563395
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02086311
43	Allograft rejection_Homo sapiens_hsa05330	1.00657843
44	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.97563443
45	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.95744109
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.94965158
47	One carbon pool by folate_Homo sapiens_hsa00670	0.91761766
48	Circadian rhythm_Homo sapiens_hsa04710	0.87882275
49	Taste transduction_Homo sapiens_hsa04742	0.85349198
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.85194982
51	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.83423206
52	Linoleic acid metabolism_Homo sapiens_hsa00591	0.79540377
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.75140846
54	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.73290867
55	Graft-versus-host disease_Homo sapiens_hsa05332	0.66652022
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60570787
57	Nicotine addiction_Homo sapiens_hsa05033	0.60187857
58	Antigen processing and presentation_Homo sapiens_hsa04612	0.58192098
59	Type I diabetes mellitus_Homo sapiens_hsa04940	0.57947801
60	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57354892
61	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.54170975
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.51416025
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.50868746
64	Rheumatoid arthritis_Homo sapiens_hsa05323	0.50336980
65	ABC transporters_Homo sapiens_hsa02010	0.50160864
66	Regulation of autophagy_Homo sapiens_hsa04140	0.50044712
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.49753645
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49131270
69	Cardiac muscle contraction_Homo sapiens_hsa04260	0.48280650
70	Herpes simplex infection_Homo sapiens_hsa05168	0.47988257
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.47382149
72	Alzheimers disease_Homo sapiens_hsa05010	0.46760686
73	Sulfur metabolism_Homo sapiens_hsa00920	0.46503978
74	Morphine addiction_Homo sapiens_hsa05032	0.45874472
75	Metabolic pathways_Homo sapiens_hsa01100	0.41907602
76	Pyruvate metabolism_Homo sapiens_hsa00620	0.41389556
77	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.37771179
78	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35797145
79	Peroxisome_Homo sapiens_hsa04146	0.34754347
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32962034
81	Butanoate metabolism_Homo sapiens_hsa00650	0.32275694
82	Nitrogen metabolism_Homo sapiens_hsa00910	0.31781016
83	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.31721185
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31622228
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31506760
86	GABAergic synapse_Homo sapiens_hsa04727	0.30546330
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.28304370
88	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.26425431
89	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.26281360
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.25657261
91	Tryptophan metabolism_Homo sapiens_hsa00380	0.25583272
92	Serotonergic synapse_Homo sapiens_hsa04726	0.24084171
93	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.23959548
94	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.22567757
95	Thyroid cancer_Homo sapiens_hsa05216	0.19119127
96	Viral carcinogenesis_Homo sapiens_hsa05203	0.19105088
97	Selenocompound metabolism_Homo sapiens_hsa00450	0.17461525
98	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.16685060
99	Chemical carcinogenesis_Homo sapiens_hsa05204	0.13850340
100	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.13095656

HNRNPA1P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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