ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sequestering of actin monomers (GO:0042989)	5.85618503
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.14427628
3	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.00582241
4	ATP synthesis coupled proton transport (GO:0015986)	4.73802684
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.73802684
6	urate metabolic process (GO:0046415)	4.67756704
7	respiratory chain complex IV assembly (GO:0008535)	4.46330677
8	rRNA modification (GO:0000154)	4.41882294
9	rRNA methylation (GO:0031167)	4.36586089
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.19538680
11	viral transcription (GO:0019083)	4.11872701
12	translational termination (GO:0006415)	4.07437293
13	diacylglycerol metabolic process (GO:0046339)	4.03992955
14	ribosomal small subunit assembly (GO:0000028)	3.92165835
15	glycerol metabolic process (GO:0006071)	3.88968992
16	mannosylation (GO:0097502)	3.77585914
17	cotranslational protein targeting to membrane (GO:0006613)	3.76182729
18	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.72973740
19	ribosomal large subunit biogenesis (GO:0042273)	3.67565456
20	protein targeting to ER (GO:0045047)	3.61542440
21	heme transport (GO:0015886)	3.61520982
22	behavioral response to nicotine (GO:0035095)	3.51821111
23	serotonin receptor signaling pathway (GO:0007210)	3.51131221
24	attachment of spindle microtubules to kinetochore (GO:0008608)	3.48826263
25	respiratory electron transport chain (GO:0022904)	3.43773647
26	protein localization to endoplasmic reticulum (GO:0070972)	3.43645648
27	alditol metabolic process (GO:0019400)	3.42611936
28	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.42053459
29	electron transport chain (GO:0022900)	3.41031427
30	cytochrome complex assembly (GO:0017004)	3.40962632
31	inner mitochondrial membrane organization (GO:0007007)	3.38169685
32	translational elongation (GO:0006414)	3.38137771
33	phospholipid homeostasis (GO:0055091)	3.37743129
34	protein complex biogenesis (GO:0070271)	3.35577502
35	response to folic acid (GO:0051593)	3.33828066
36	chaperone-mediated protein transport (GO:0072321)	3.31987685
37	protein-cofactor linkage (GO:0018065)	3.28346507
38	DNA damage response, detection of DNA damage (GO:0042769)	3.27378164
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.16768640
40	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.16615340
41	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.14023945
42	phasic smooth muscle contraction (GO:0014821)	3.06577034
43	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.05375576
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.05375576
45	NADH dehydrogenase complex assembly (GO:0010257)	3.05375576
46	fucose catabolic process (GO:0019317)	3.04094437
47	L-fucose metabolic process (GO:0042354)	3.04094437
48	L-fucose catabolic process (GO:0042355)	3.04094437
49	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.04068930
50	base-excision repair, AP site formation (GO:0006285)	3.03777326
51	protein neddylation (GO:0045116)	2.96052574
52	translational initiation (GO:0006413)	2.95864095
53	cellular protein complex disassembly (GO:0043624)	2.94895708
54	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.93300323
55	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.90744463
56	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.90744463
57	lung secretory cell differentiation (GO:0061140)	2.89946145
58	oxidative phosphorylation (GO:0006119)	2.88257090
59	protein localization to kinetochore (GO:0034501)	2.87807730
60	ATP biosynthetic process (GO:0006754)	2.86271652
61	S-adenosylmethionine metabolic process (GO:0046500)	2.84172301
62	DNA deamination (GO:0045006)	2.83733338
63	viral life cycle (GO:0019058)	2.82977363
64	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.81190233
65	translation (GO:0006412)	2.76345267
66	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.68241681
67	grooming behavior (GO:0007625)	2.64499924
68	ribonucleoprotein complex disassembly (GO:0032988)	2.63084782
69	lactate metabolic process (GO:0006089)	2.63044161
70	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.62867735
71	heart field specification (GO:0003128)	2.61737088
72	secondary heart field specification (GO:0003139)	2.61737088
73	organelle disassembly (GO:1903008)	2.61370330
74	adult feeding behavior (GO:0008343)	2.60900738
75	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.60510835
76	retinal cone cell development (GO:0046549)	2.57799851
77	DNA double-strand break processing (GO:0000729)	2.56874639
78	low-density lipoprotein particle remodeling (GO:0034374)	2.56574536
79	cardiac right ventricle morphogenesis (GO:0003215)	2.55580470
80	proteasome assembly (GO:0043248)	2.55506766
81	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.51293300
82	macromolecular complex disassembly (GO:0032984)	2.51035792
83	protein complex disassembly (GO:0043241)	2.50116022
84	intracellular protein transmembrane import (GO:0044743)	2.48566609
85	iron coordination entity transport (GO:1901678)	2.47931889
86	protein homotrimerization (GO:0070207)	2.45973533
87	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.43680155
88	termination of RNA polymerase III transcription (GO:0006386)	2.43680155
89	purine-containing compound salvage (GO:0043101)	2.41136730
90	mRNA catabolic process (GO:0006402)	2.40026437
91	neuron fate determination (GO:0048664)	2.39571997
92	regulation of sarcomere organization (GO:0060297)	2.38390821
93	forebrain neuron differentiation (GO:0021879)	2.38321661
94	regulation of mitotic spindle checkpoint (GO:1903504)	2.37739405
95	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.37739405
96	pituitary gland development (GO:0021983)	2.36395376
97	hydrogen ion transmembrane transport (GO:1902600)	2.36381933
98	negative regulation of neurological system process (GO:0031645)	2.34590435
99	retinal ganglion cell axon guidance (GO:0031290)	2.33087322
100	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.31308739

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.77523794
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.75882906
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.61113350
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.39173669
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.33393293
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.04843766
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.03913296
8	VDR_22108803_ChIP-Seq_LS180_Human	2.93653445
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.69586966
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.62767342
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.54802973
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.42755108
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.40599039
14	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.38845518
15	EWS_26573619_Chip-Seq_HEK293_Human	2.35262497
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.31657790
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.12249397
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.09898858
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.04172913
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.02801411
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.97267439
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.96672936
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.94097738
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.87802827
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.85834622
26	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.81328069
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.80132824
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.78351147
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.75986934
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.74799273
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.72467720
32	FUS_26573619_Chip-Seq_HEK293_Human	1.71443182
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.59404446
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56896854
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.54985084
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.54029214
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.50409123
38	P300_19829295_ChIP-Seq_ESCs_Human	1.47880199
39	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.41634458
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.41259341
41	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.40682632
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.36644557
43	XRN2_22483619_ChIP-Seq_HELA_Human	1.36643825
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35936325
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34256526
46	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.33138359
47	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.32898876
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.29460498
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28532257
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23599732
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.23599732
52	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.22884768
53	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22639661
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.20869362
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20797908
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.19981190
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19705463
58	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.18679403
59	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.18067732
60	DCP1A_22483619_ChIP-Seq_HELA_Human	1.17557869
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16532788
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16532788
63	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.15986993
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13525044
65	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.11303620
66	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.09389803
67	GBX2_23144817_ChIP-Seq_PC3_Human	1.09190685
68	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.08686457
69	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.08482493
70	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08292099
71	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.08275672
72	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.07929847
73	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.06709483
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06537908
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05782703
76	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.03639627
77	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.02091888
78	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01427587
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.00738107
80	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00697228
81	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.99997951
82	BCAT_22108803_ChIP-Seq_LS180_Human	0.99649170
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.99497079
84	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.99497079
85	AR_20517297_ChIP-Seq_VCAP_Human	0.98096883
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97858132
87	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.97341778
88	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96416987
89	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93806525
90	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93661794
91	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.93644619
92	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.92296224
93	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.90596929
94	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.90528146
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.89868300
96	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.88717097
97	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.88565677
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.87910233
99	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.86897202
100	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.85354604

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.89395926
2	MP0006072_abnormal_retinal_apoptosis	3.62219695
3	MP0006292_abnormal_olfactory_placode	2.93405600
4	MP0005084_abnormal_gallbladder_morpholo	2.91782873
5	MP0006276_abnormal_autonomic_nervous	2.57733006
6	MP0008995_early_reproductive_senescence	2.55005710
7	MP0008058_abnormal_DNA_repair	2.48342700
8	MP0005646_abnormal_pituitary_gland	2.47165297
9	MP0003011_delayed_dark_adaptation	2.45457140
10	MP0004133_heterotaxia	2.34033411
11	MP0000372_irregular_coat_pigmentation	2.28763723
12	MP0005551_abnormal_eye_electrophysiolog	2.15575405
13	MP0008877_abnormal_DNA_methylation	2.14780041
14	MP0005167_abnormal_blood-brain_barrier	2.12667445
15	MP0005253_abnormal_eye_physiology	2.07286254
16	MP0002938_white_spotting	2.04359231
17	MP0000631_abnormal_neuroendocrine_gland	2.01032183
18	MP0002736_abnormal_nociception_after	1.93182604
19	MP0001293_anophthalmia	1.84533904
20	MP0002254_reproductive_system_inflammat	1.82539985
21	MP0001764_abnormal_homeostasis	1.80088269
22	MP0002234_abnormal_pharynx_morphology	1.72619524
23	MP0005645_abnormal_hypothalamus_physiol	1.72095539
24	MP0003567_abnormal_fetal_cardiomyocyte	1.71823963
25	MP0003718_maternal_effect	1.69812970
26	MP0002277_abnormal_respiratory_mucosa	1.55519713
27	MP0001529_abnormal_vocalization	1.55501425
28	MP0001873_stomach_inflammation	1.53851748
29	MP0001968_abnormal_touch/_nociception	1.51093458
30	MP0005085_abnormal_gallbladder_physiolo	1.49908889
31	MP0002928_abnormal_bile_duct	1.49377478
32	MP0003195_calcinosis	1.47786056
33	MP0003880_abnormal_central_pattern	1.44948171
34	MP0001879_abnormal_lymphatic_vessel	1.36286462
35	MP0008872_abnormal_physiological_respon	1.34852062
36	MP0003786_premature_aging	1.34743443
37	MP0002751_abnormal_autonomic_nervous	1.34037664
38	MP0008961_abnormal_basal_metabolism	1.33907105
39	MP0001486_abnormal_startle_reflex	1.32637279
40	MP0003787_abnormal_imprinting	1.32368680
41	MP0003122_maternal_imprinting	1.27601496
42	MP0001501_abnormal_sleep_pattern	1.25214972
43	MP0002822_catalepsy	1.23220259
44	MP0004142_abnormal_muscle_tone	1.17999168
45	MP0003638_abnormal_response/metabolism_	1.17285096
46	MP0002876_abnormal_thyroid_physiology	1.16817711
47	MP0005391_vision/eye_phenotype	1.15218587
48	MP0006035_abnormal_mitochondrial_morpho	1.13064013
49	MP0009745_abnormal_behavioral_response	1.08806190
50	MP0002272_abnormal_nervous_system	1.08018792
51	MP0009379_abnormal_foot_pigmentation	1.07069589
52	MP0003693_abnormal_embryo_hatching	1.06770553
53	MP0002090_abnormal_vision	1.06627080
54	MP0003121_genomic_imprinting	1.06099412
55	MP0003111_abnormal_nucleus_morphology	1.05517474
56	MP0003186_abnormal_redox_activity	1.01477864
57	MP0002572_abnormal_emotion/affect_behav	0.98307472
58	MP0006036_abnormal_mitochondrial_physio	0.96763687
59	MP0004215_abnormal_myocardial_fiber	0.96047761
60	MP0005220_abnormal_exocrine_pancreas	0.95467014
61	MP0003119_abnormal_digestive_system	0.94926641
62	MP0005332_abnormal_amino_acid	0.94556257
63	MP0005075_abnormal_melanosome_morpholog	0.93754285
64	MP0002102_abnormal_ear_morphology	0.93641279
65	MP0000230_abnormal_systemic_arterial	0.93497627
66	MP0001905_abnormal_dopamine_level	0.92591991
67	MP0001944_abnormal_pancreas_morphology	0.92320563
68	MP0001440_abnormal_grooming_behavior	0.89806020
69	MP0001502_abnormal_circadian_rhythm	0.89605768
70	MP0003724_increased_susceptibility_to	0.89037477
71	MP0008789_abnormal_olfactory_epithelium	0.86477590
72	MP0000653_abnormal_sex_gland	0.85784878
73	MP0008775_abnormal_heart_ventricle	0.83863596
74	MP0010094_abnormal_chromosome_stability	0.83021704
75	MP0005408_hypopigmentation	0.82697548
76	MP0001661_extended_life_span	0.81803580
77	MP0005394_taste/olfaction_phenotype	0.81183222
78	MP0005499_abnormal_olfactory_system	0.81183222
79	MP0001986_abnormal_taste_sensitivity	0.80772415
80	MP0002638_abnormal_pupillary_reflex	0.80062680
81	MP0009697_abnormal_copulation	0.79737645
82	MP0002557_abnormal_social/conspecific_i	0.79639727
83	MP0002734_abnormal_mechanical_nocicepti	0.79271209
84	MP0002733_abnormal_thermal_nociception	0.79166530
85	MP0005195_abnormal_posterior_eye	0.78020177
86	MP0008875_abnormal_xenobiotic_pharmacok	0.76774049
87	MP0002693_abnormal_pancreas_physiology	0.76508468
88	MP0005671_abnormal_response_to	0.74467568
89	MP0001346_abnormal_lacrimal_gland	0.72709402
90	MP0001145_abnormal_male_reproductive	0.72486824
91	MP0002735_abnormal_chemical_nociception	0.71885879
92	MP0002210_abnormal_sex_determination	0.71556247
93	MP0005647_abnormal_sex_gland	0.71417835
94	MP0001970_abnormal_pain_threshold	0.70599549
95	MP0001929_abnormal_gametogenesis	0.69584719
96	MP0003137_abnormal_impulse_conducting	0.69552805
97	MP0004885_abnormal_endolymph	0.69102689
98	MP0000639_abnormal_adrenal_gland	0.69071491
99	MP0003283_abnormal_digestive_organ	0.67793572
100	MP0004019_abnormal_vitamin_homeostasis	0.67116804

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	4.10523345
2	Mitochondrial inheritance (HP:0001427)	4.08585319
3	Acute necrotizing encephalopathy (HP:0006965)	4.02311682
4	Progressive macrocephaly (HP:0004481)	3.63246783
5	Acute encephalopathy (HP:0006846)	3.62903310
6	Thyroid-stimulating hormone excess (HP:0002925)	3.57569621
7	Lipid accumulation in hepatocytes (HP:0006561)	3.57460258
8	Hepatocellular necrosis (HP:0001404)	3.49332699
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.44529474
10	Increased CSF lactate (HP:0002490)	3.41178983
11	Delayed CNS myelination (HP:0002188)	3.37338538
12	Congenital stationary night blindness (HP:0007642)	3.24751400
13	Renal Fanconi syndrome (HP:0001994)	3.16825336
14	Hepatic necrosis (HP:0002605)	3.10987674
15	Attenuation of retinal blood vessels (HP:0007843)	3.07651480
16	Stenosis of the external auditory canal (HP:0000402)	2.96112575
17	Decreased central vision (HP:0007663)	2.95933148
18	Hyperinsulinemic hypoglycemia (HP:0000825)	2.88613853
19	Reticulocytopenia (HP:0001896)	2.81082668
20	Type I transferrin isoform profile (HP:0003642)	2.78022164
21	Stomach cancer (HP:0012126)	2.72783441
22	Cerebral edema (HP:0002181)	2.70513323
23	3-Methylglutaconic aciduria (HP:0003535)	2.67070386
24	Pancreatic fibrosis (HP:0100732)	2.64126000
25	Hypoglycemic seizures (HP:0002173)	2.60701717
26	Methylmalonic aciduria (HP:0012120)	2.56259955
27	Cerebellar dysplasia (HP:0007033)	2.53981999
28	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.53378584
29	Methylmalonic acidemia (HP:0002912)	2.52593028
30	Congenital, generalized hypertrichosis (HP:0004540)	2.52220131
31	Pancreatic cysts (HP:0001737)	2.51836666
32	Macrocytic anemia (HP:0001972)	2.45534539
33	Pendular nystagmus (HP:0012043)	2.45383800
34	Intestinal atresia (HP:0011100)	2.44577487
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.42401886
36	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.41154365
37	Abolished electroretinogram (ERG) (HP:0000550)	2.40674795
38	Hyperglycinemia (HP:0002154)	2.40001654
39	Autoimmune thrombocytopenia (HP:0001973)	2.39631376
40	Hypoglycemic coma (HP:0001325)	2.38278141
41	Medial flaring of the eyebrow (HP:0010747)	2.37766551
42	Abnormality of the labia minora (HP:0012880)	2.33435078
43	Hypothermia (HP:0002045)	2.33230152
44	Exertional dyspnea (HP:0002875)	2.29796155
45	Gout (HP:0001997)	2.29173133
46	Asplenia (HP:0001746)	2.27124979
47	Lactic acidosis (HP:0003128)	2.27065452
48	Increased intramyocellular lipid droplets (HP:0012240)	2.26414342
49	Molar tooth sign on MRI (HP:0002419)	2.25614834
50	Abnormality of midbrain morphology (HP:0002418)	2.25614834
51	Nephronophthisis (HP:0000090)	2.23745643
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.21128122
53	True hermaphroditism (HP:0010459)	2.20056956
54	Lethargy (HP:0001254)	2.19113405
55	Optic disc pallor (HP:0000543)	2.18954607
56	Respiratory failure (HP:0002878)	2.18334029
57	Exercise-induced muscle cramps (HP:0003710)	2.13425033
58	Abnormal number of erythroid precursors (HP:0012131)	2.13324747
59	Increased serum lactate (HP:0002151)	2.13047117
60	Hyperglycinuria (HP:0003108)	2.11681134
61	Abnormal protein glycosylation (HP:0012346)	2.10040108
62	Abnormal glycosylation (HP:0012345)	2.10040108
63	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.10040108
64	Abnormal protein N-linked glycosylation (HP:0012347)	2.10040108
65	Type II lissencephaly (HP:0007260)	2.09808666
66	Abnormal lung lobation (HP:0002101)	2.03351447
67	Type 2 muscle fiber atrophy (HP:0003554)	2.02914143
68	Abnormality of renal resorption (HP:0011038)	2.02657184
69	Inability to walk (HP:0002540)	2.01324555
70	Testicular atrophy (HP:0000029)	2.00309514
71	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.99319696
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.98294921
73	Abnormality of alanine metabolism (HP:0010916)	1.98294921
74	Hyperalaninemia (HP:0003348)	1.98294921
75	Hyperphosphaturia (HP:0003109)	1.97271893
76	Aplasia/hypoplasia of the uterus (HP:0008684)	1.95852067
77	Exercise intolerance (HP:0003546)	1.94034444
78	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.93134666
79	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.93134666
80	Supernumerary spleens (HP:0009799)	1.92742406
81	Abnormality of cells of the erythroid lineage (HP:0012130)	1.92364379
82	Glycosuria (HP:0003076)	1.91624257
83	Abnormality of urine glucose concentration (HP:0011016)	1.91624257
84	Oral leukoplakia (HP:0002745)	1.89109119
85	Prostate neoplasm (HP:0100787)	1.88648206
86	Abnormality of the renal medulla (HP:0100957)	1.88238998
87	Neonatal respiratory distress (HP:0002643)	1.87538103
88	Abnormality of the prostate (HP:0008775)	1.86662917
89	Polyphagia (HP:0002591)	1.86350416
90	Rimmed vacuoles (HP:0003805)	1.85596547
91	Chronic hepatic failure (HP:0100626)	1.85209644
92	Hyperlipoproteinemia (HP:0010980)	1.84691875
93	Colon cancer (HP:0003003)	1.84643520
94	Prolonged partial thromboplastin time (HP:0003645)	1.83057886
95	Severe muscular hypotonia (HP:0006829)	1.82939425
96	Pancreatic islet-cell hyperplasia (HP:0004510)	1.82355044
97	Respiratory difficulties (HP:0002880)	1.82172469
98	Abnormality of the pons (HP:0007361)	1.81551263
99	Abnormality of macular pigmentation (HP:0008002)	1.81286043
100	Aplastic anemia (HP:0001915)	1.80584681

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	4.54950751
2	ZAK	3.66724905
3	TXK	3.21929668
4	NUAK1	2.70080526
5	MKNK1	2.63978433
6	TAOK3	2.58125145
7	SRPK1	2.50757203
8	BMPR1B	2.35954245
9	GRK1	2.31525244
10	WNK3	2.24689981
11	MAP4K2	2.15504781
12	BCKDK	2.08784254
13	BUB1	2.02618266
14	TNIK	1.99048159
15	VRK2	1.94709219
16	TSSK6	1.78285127
17	PINK1	1.73826116
18	MST4	1.69476887
19	VRK1	1.60423447
20	FRK	1.59847122
21	ADRBK2	1.59779583
22	EIF2AK3	1.47950239
23	PASK	1.45021945
24	NEK1	1.44809796
25	PLK4	1.42503870
26	PLK3	1.37738713
27	CDK19	1.34280473
28	FLT3	1.33043192
29	BMPR2	1.31122584
30	FGFR2	1.31035087
31	MAPKAPK5	1.24730879
32	TEC	1.16835178
33	EPHA3	1.09107858
34	AKT3	1.08301925
35	PBK	1.07494603
36	TGFBR1	1.00350817
37	KDR	1.00289253
38	PNCK	0.99435769
39	TNK2	0.98999329
40	PHKG2	0.98436249
41	PHKG1	0.98436249
42	INSRR	0.96530574
43	STK24	0.91101045
44	ERBB3	0.85686632
45	NME2	0.85585717
46	ALK	0.83663443
47	BCR	0.83607217
48	MARK1	0.80644196
49	WEE1	0.76926378
50	DYRK2	0.75610824
51	OXSR1	0.72039825
52	SIK3	0.68567397
53	TAF1	0.67694816
54	PIM1	0.67627402
55	CAMK2A	0.65526791
56	PRKCG	0.64398207
57	PRKCE	0.64350694
58	FGFR1	0.63002501
59	MAPK7	0.62884090
60	TRIM28	0.62396943
61	TLK1	0.61351795
62	MAPK13	0.59913397
63	MKNK2	0.57844452
64	CSNK1G1	0.57784163
65	PRKG2	0.56333715
66	NTRK3	0.55985745
67	PDK2	0.53617731
68	MAP4K1	0.53256397
69	MAP3K12	0.53189957
70	IGF1R	0.52273885
71	EIF2AK2	0.52107930
72	TTK	0.51741805
73	CSNK2A1	0.51171032
74	BTK	0.51113343
75	WNK4	0.50959281
76	ADRBK1	0.50944508
77	PLK1	0.50132477
78	CSNK1G2	0.49827573
79	DYRK3	0.48340306
80	CSNK1A1	0.48058388
81	EPHA4	0.47394966
82	MAPK15	0.47258432
83	LATS1	0.47096805
84	RPS6KA5	0.44529105
85	PAK3	0.44351197
86	MINK1	0.43698230
87	MAP2K6	0.42924973
88	PRKCQ	0.41211088
89	PRKACA	0.41157655
90	CSNK2A2	0.41123178
91	LYN	0.40290417
92	PRKG1	0.40261924
93	CAMK2D	0.40168016
94	ITK	0.40111090
95	MATK	0.39463738
96	MAP3K4	0.37796392
97	AURKB	0.37298756
98	ATM	0.37110519
99	ATR	0.36978138
100	NLK	0.36347625

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.07142800
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.64426348
3	Parkinsons disease_Homo sapiens_hsa05012	3.37142989
4	Proteasome_Homo sapiens_hsa03050	3.30164221
5	Protein export_Homo sapiens_hsa03060	2.90565932
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.23305170
7	Huntingtons disease_Homo sapiens_hsa05016	2.09083765
8	Propanoate metabolism_Homo sapiens_hsa00640	2.02280102
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.01394946
10	RNA polymerase_Homo sapiens_hsa03020	1.93041879
11	Alzheimers disease_Homo sapiens_hsa05010	1.87687968
12	Basal transcription factors_Homo sapiens_hsa03022	1.86015981
13	Spliceosome_Homo sapiens_hsa03040	1.82935187
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.79311827
15	Homologous recombination_Homo sapiens_hsa03440	1.79302011
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.71852426
17	Phototransduction_Homo sapiens_hsa04744	1.71329550
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.71087469
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.70996507
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.65941369
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.62337587
22	One carbon pool by folate_Homo sapiens_hsa00670	1.61529325
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.60909923
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.56872418
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.54051619
26	Mismatch repair_Homo sapiens_hsa03430	1.51755453
27	RNA degradation_Homo sapiens_hsa03018	1.47967621
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.45904941
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.39377766
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.39247511
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.33191322
32	Base excision repair_Homo sapiens_hsa03410	1.25836254
33	Nicotine addiction_Homo sapiens_hsa05033	1.24253185
34	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.24057884
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20336390
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19896238
37	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.17698220
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.15386386
39	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.13589685
40	Peroxisome_Homo sapiens_hsa04146	1.07041841
41	Butanoate metabolism_Homo sapiens_hsa00650	1.05966223
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.04617024
43	Non-homologous end-joining_Homo sapiens_hsa03450	1.00338038
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99540743
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.99092409
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.98520396
47	Taste transduction_Homo sapiens_hsa04742	0.98147763
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.97855134
49	RNA transport_Homo sapiens_hsa03013	0.94972230
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.94538599
51	Purine metabolism_Homo sapiens_hsa00230	0.93955854
52	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.93823894
53	Serotonergic synapse_Homo sapiens_hsa04726	0.90275317
54	Fatty acid elongation_Homo sapiens_hsa00062	0.87714988
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87473874
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.87354540
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.81904955
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79053719
59	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.77525213
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77272906
61	Metabolic pathways_Homo sapiens_hsa01100	0.75747369
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74987422
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74250960
64	Glutathione metabolism_Homo sapiens_hsa00480	0.73180942
65	GABAergic synapse_Homo sapiens_hsa04727	0.66399072
66	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.66320833
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61280029
68	Retinol metabolism_Homo sapiens_hsa00830	0.61279988
69	Pyruvate metabolism_Homo sapiens_hsa00620	0.60166653
70	ABC transporters_Homo sapiens_hsa02010	0.59831650
71	Fatty acid degradation_Homo sapiens_hsa00071	0.56474228
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.54575217
73	mRNA surveillance pathway_Homo sapiens_hsa03015	0.54552841
74	Long-term depression_Homo sapiens_hsa04730	0.54222103
75	Caffeine metabolism_Homo sapiens_hsa00232	0.52410800
76	DNA replication_Homo sapiens_hsa03030	0.51584579
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51155226
78	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.51117383
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.48341360
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.47971876
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.45058254
82	Asthma_Homo sapiens_hsa05310	0.44697186
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.43696283
84	Morphine addiction_Homo sapiens_hsa05032	0.41805451
85	Olfactory transduction_Homo sapiens_hsa04740	0.39104054
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.39072291
87	Circadian entrainment_Homo sapiens_hsa04713	0.38041798
88	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.37403802
89	Regulation of autophagy_Homo sapiens_hsa04140	0.36824324
90	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34424467
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.33564755
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33516368
93	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.33186444
94	Type I diabetes mellitus_Homo sapiens_hsa04940	0.31850118
95	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.31735687
96	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.31735414
97	Primary immunodeficiency_Homo sapiens_hsa05340	0.30800080
98	Cocaine addiction_Homo sapiens_hsa05030	0.28178501
99	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.27476305
100	Mineral absorption_Homo sapiens_hsa04978	0.26781710

HNRNPA1P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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