HNRNPA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.91541451
2DNA unwinding involved in DNA replication (GO:0006268)5.02111935
3pre-miRNA processing (GO:0031054)5.01126635
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.90671536
5nuclear pore organization (GO:0006999)4.66753344
6nuclear pore complex assembly (GO:0051292)4.62437678
7protein localization to kinetochore (GO:0034501)4.50979361
8negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.45707965
9negative regulation of RNA splicing (GO:0033119)4.23617635
10sister chromatid segregation (GO:0000819)4.20166466
11regulation of RNA export from nucleus (GO:0046831)4.08531858
12mRNA stabilization (GO:0048255)4.03870915
13RNA stabilization (GO:0043489)4.03870915
14establishment of integrated proviral latency (GO:0075713)4.02151897
15glucocorticoid receptor signaling pathway (GO:0042921)4.00018222
16regulation of sister chromatid cohesion (GO:0007063)3.99384822
17negative regulation of mRNA processing (GO:0050686)3.97500187
18formation of translation preinitiation complex (GO:0001731)3.95284961
19heterochromatin organization (GO:0070828)3.87199898
20DNA strand elongation involved in DNA replication (GO:0006271)3.86785561
21negative regulation of histone methylation (GO:0031061)3.79482343
22regulation of DNA endoreduplication (GO:0032875)3.76162806
23DNA strand elongation (GO:0022616)3.74540729
24protein localization to chromosome, centromeric region (GO:0071459)3.74163575
25negative regulation of mRNA metabolic process (GO:1903312)3.73351906
26kinetochore organization (GO:0051383)3.73284618
27mitotic chromosome condensation (GO:0007076)3.72165381
28alternative mRNA splicing, via spliceosome (GO:0000380)3.67980682
29mitotic sister chromatid segregation (GO:0000070)3.66316002
30DNA replication initiation (GO:0006270)3.64386044
31mitotic nuclear envelope disassembly (GO:0007077)3.60695094
32protein complex localization (GO:0031503)3.60537880
33cellular protein complex localization (GO:0034629)3.60466702
34DNA topological change (GO:0006265)3.54772133
35DNA duplex unwinding (GO:0032508)3.50742029
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.49556014
37DNA geometric change (GO:0032392)3.48456188
38membrane disassembly (GO:0030397)3.46199371
39nuclear envelope disassembly (GO:0051081)3.46199371
40regulation of histone H3-K27 methylation (GO:0061085)3.38545339
41regulation of mRNA stability (GO:0043488)3.37382800
42mitotic metaphase plate congression (GO:0007080)3.34577540
43peptidyl-lysine dimethylation (GO:0018027)3.33355300
44dosage compensation (GO:0007549)3.32169761
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.28340776
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.28340776
47positive regulation of mitotic sister chromatid separation (GO:1901970)3.28340776
48pore complex assembly (GO:0046931)3.25686646
49regulation of spindle organization (GO:0090224)3.24670192
50positive regulation of chromosome segregation (GO:0051984)3.21384604
51regulation of nucleobase-containing compound transport (GO:0032239)3.17256141
52corticosteroid receptor signaling pathway (GO:0031958)3.15164311
53planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13331116
543-UTR-mediated mRNA stabilization (GO:0070935)3.12606153
55protein export from nucleus (GO:0006611)3.12550265
56cytoplasmic mRNA processing body assembly (GO:0033962)3.12277155
57metaphase plate congression (GO:0051310)3.11814520
58regulation of RNA stability (GO:0043487)3.11631946
59protein localization to chromosome (GO:0034502)3.09578851
60ribosomal small subunit biogenesis (GO:0042274)3.09346731
61regulation of histone H3-K9 methylation (GO:0051570)3.09306779
62IMP biosynthetic process (GO:0006188)3.08437016
63DNA packaging (GO:0006323)3.08110814
64regulation of mitotic spindle organization (GO:0060236)3.05610161
65regulation of centriole replication (GO:0046599)3.05396142
66telomere maintenance via semi-conservative replication (GO:0032201)3.05380548
67NLS-bearing protein import into nucleus (GO:0006607)3.04115824
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03613478
69positive regulation of cell cycle checkpoint (GO:1901978)3.02799232
70chromatin assembly (GO:0031497)3.02457333
71* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.02126830
72* mRNA splicing, via spliceosome (GO:0000398)3.02126830
73paraxial mesoderm development (GO:0048339)3.01784277
74ATP-dependent chromatin remodeling (GO:0043044)3.01403667
75* RNA splicing, via transesterification reactions (GO:0000375)2.99875994
76negative regulation of DNA repair (GO:0045738)2.99068891
77folic acid-containing compound biosynthetic process (GO:0009396)2.97815143
78DNA replication-dependent nucleosome assembly (GO:0006335)2.97761816
79DNA replication-dependent nucleosome organization (GO:0034723)2.97761816
80hippo signaling (GO:0035329)2.95580398
81IMP metabolic process (GO:0046040)2.92415030
82V(D)J recombination (GO:0033151)2.91765290
83chromatin assembly or disassembly (GO:0006333)2.91402159
84regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.89910904
85mRNA splice site selection (GO:0006376)2.89681369
86regulation of translational fidelity (GO:0006450)2.86535046
87regulation of NFAT protein import into nucleus (GO:0051532)2.86457640
88histone H2B ubiquitination (GO:0033523)2.85660822
89DNA conformation change (GO:0071103)2.85345176
90DNA replication checkpoint (GO:0000076)2.85264250
91regulation of chromosome segregation (GO:0051983)2.85120873
92kinetochore assembly (GO:0051382)2.84720056
93spliceosomal tri-snRNP complex assembly (GO:0000244)2.84518923
94nucleosome disassembly (GO:0006337)2.80749265
95protein-DNA complex disassembly (GO:0032986)2.80749265
96peptidyl-arginine N-methylation (GO:0035246)2.79441506
97peptidyl-arginine methylation (GO:0018216)2.79441506
98regulation of centrosome cycle (GO:0046605)2.78614233
99nucleic acid transport (GO:0050657)2.77076864
100RNA transport (GO:0050658)2.77076864
101establishment of RNA localization (GO:0051236)2.77076864
102DNA replication-independent nucleosome organization (GO:0034724)2.77034640
103DNA replication-independent nucleosome assembly (GO:0006336)2.77034640
104translesion synthesis (GO:0019985)2.75860162
105cellular response to epidermal growth factor stimulus (GO:0071364)2.75242295
106nuclear envelope organization (GO:0006998)2.74740238
107maturation of SSU-rRNA (GO:0030490)2.73935571
108establishment of chromosome localization (GO:0051303)2.73537608
109mitotic recombination (GO:0006312)2.73475237
110histone H2A monoubiquitination (GO:0035518)2.73047933
111positive regulation of RNA splicing (GO:0033120)2.72965236
112regulation of mitotic metaphase/anaphase transition (GO:0030071)2.72517613
113DNA synthesis involved in DNA repair (GO:0000731)2.71850844
114attachment of spindle microtubules to kinetochore (GO:0008608)2.71620198
115peptidyl-arginine omega-N-methylation (GO:0035247)2.71102481
116viral transcription (GO:0019083)2.70818690
117mRNA transport (GO:0051028)2.70649146
118regulation of telomere maintenance via telomerase (GO:0032210)2.70493338
119termination of RNA polymerase II transcription (GO:0006369)2.69336110
120regulation of stem cell maintenance (GO:2000036)2.69123313
121spindle checkpoint (GO:0031577)2.67771465
122RNA export from nucleus (GO:0006405)2.67505310
123chromosome segregation (GO:0007059)2.67430433
124spindle assembly checkpoint (GO:0071173)2.67164114
125chromosome condensation (GO:0030261)2.67104206
126establishment of viral latency (GO:0019043)2.66578210
127convergent extension (GO:0060026)2.65298391
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.64795494
129translational termination (GO:0006415)2.64624545
130regulation of histone methylation (GO:0031060)2.64529520
131negative regulation of histone acetylation (GO:0035067)2.61449337
132positive regulation of gene expression, epigenetic (GO:0045815)2.60756007
133mitotic spindle checkpoint (GO:0071174)2.59872759
134regulation of centrosome duplication (GO:0010824)2.59400686
135mitotic spindle assembly checkpoint (GO:0007094)2.59027444
136nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.58283401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.80704746
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.47682637
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.45422710
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54617061
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.33486722
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.26211340
7MYC_22102868_ChIP-Seq_BL_Human3.11883364
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72452415
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.72047251
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70632694
11AR_21909140_ChIP-Seq_LNCAP_Human2.62519433
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.61286860
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.55277813
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.50610162
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27020559
16E2F7_22180533_ChIP-Seq_HELA_Human10.3697412
17MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98690902
18CIITA_25753668_ChIP-Seq_RAJI_Human1.94039640
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.89221470
20XRN2_22483619_ChIP-Seq_HELA_Human1.86791070
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83352350
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.67788709
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.67595629
24PKCTHETA_26484144_Chip-Seq_BREAST_Human1.66986068
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64471375
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64127387
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62843485
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57744918
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57568117
30* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.52146282
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.51562550
32DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.49951462
33KDM5A_27292631_Chip-Seq_BREAST_Human1.49346918
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48782978
35CHD1_26751641_Chip-Seq_LNCaP_Human1.48427578
36TCF7_22412390_ChIP-Seq_EML_Mouse1.46141370
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43862520
38NANOG_21062744_ChIP-ChIP_HESCs_Human1.43731822
39* TTF2_22483619_ChIP-Seq_HELA_Human1.43041709
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42809680
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41364148
42* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.41215842
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.40750904
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37639524
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37093581
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35203868
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34458987
48VDR_21846776_ChIP-Seq_THP-1_Human1.34317489
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29956552
50* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29662203
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27164087
52KDM2B_26808549_Chip-Seq_DND41_Human1.26026084
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24719302
54TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24016295
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23716457
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22788211
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22786568
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22580286
59DCP1A_22483619_ChIP-Seq_HELA_Human1.22281451
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20073944
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20010174
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18577357
63SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17162516
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14349822
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11646702
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10437518
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09718474
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09263192
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09093825
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08602967
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07648893
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07319577
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06063585
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06002670
75ELK1_19687146_ChIP-ChIP_HELA_Human1.05707562
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04130423
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03973097
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03771708
79CLOCK_20551151_ChIP-Seq_293T_Human1.03233809
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02566615
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.01909883
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.01117446
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00046543
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97348755
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97348755
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97348755
87* UTX_26944678_Chip-Seq_JUKART_Human0.97031544
88NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96337986
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95969969
90* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95897729
91ZNF263_19887448_ChIP-Seq_K562_Human0.94728927
92* FOXP3_21729870_ChIP-Seq_TREG_Human0.93402185
93KDM2B_26808549_Chip-Seq_K562_Human0.93089028
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92129650
95TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90901451
96EST1_17652178_ChIP-ChIP_JURKAT_Human0.89881455
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89670611
98WT1_19549856_ChIP-ChIP_CCG9911_Human0.89444557
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89214381
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88986722
101TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88680630
102HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88274851
103VDR_23849224_ChIP-Seq_CD4+_Human0.87460679
104POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86626846
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86479398
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86227906
107KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85826669
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85515754
109POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.85450497
110RACK7_27058665_Chip-Seq_MCF-7_Human0.85201924
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84928315
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84565846
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84271659
114CREB1_15753290_ChIP-ChIP_HEK293T_Human0.84031720
115GABP_19822575_ChIP-Seq_HepG2_Human0.83939883
116KAP1_27257070_Chip-Seq_ESCs_Mouse0.83345950
117SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82730908
118* NCOR1_26117541_ChIP-Seq_K562_Human0.82557087
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82110189
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82060549
121ISL1_27105846_Chip-Seq_CPCs_Mouse0.79221468

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting3.19600411
2MP0003693_abnormal_embryo_hatching2.94059557
3MP0003111_abnormal_nucleus_morphology2.90720553
4MP0010094_abnormal_chromosome_stability2.87579616
5MP0004957_abnormal_blastocyst_morpholog2.86135279
6MP0005076_abnormal_cell_differentiation2.77190950
7MP0010352_gastrointestinal_tract_polyps2.68498499
8MP0000537_abnormal_urethra_morphology2.62309626
9MP0003121_genomic_imprinting2.53336968
10MP0003077_abnormal_cell_cycle2.52241928
11MP0000566_synostosis2.50850224
12MP0008057_abnormal_DNA_replication2.41227471
13MP0003705_abnormal_hypodermis_morpholog2.32400230
14MP0009053_abnormal_anal_canal2.31844580
15MP0001730_embryonic_growth_arrest2.19672495
16MP0002009_preneoplasia2.12899552
17MP0010234_abnormal_vibrissa_follicle2.10959324
18MP0002084_abnormal_developmental_patter2.08794472
19MP0003890_abnormal_embryonic-extraembry2.08502799
20MP0004197_abnormal_fetal_growth/weight/2.04625674
21MP0010030_abnormal_orbit_morphology1.98856893
22MP0003122_maternal_imprinting1.98496522
23MP0000350_abnormal_cell_proliferation1.97317764
24MP0002085_abnormal_embryonic_tissue1.88324998
25MP0001672_abnormal_embryogenesis/_devel1.87118730
26MP0005380_embryogenesis_phenotype1.87118730
27MP0003567_abnormal_fetal_cardiomyocyte1.85210959
28MP0004185_abnormal_adipocyte_glucose1.83374267
29MP0001697_abnormal_embryo_size1.81859281
30MP0005187_abnormal_penis_morphology1.79312794
31MP0003984_embryonic_growth_retardation1.75652435
32MP0002088_abnormal_embryonic_growth/wei1.75248349
33MP0002086_abnormal_extraembryonic_tissu1.72665397
34MP0001293_anophthalmia1.69020419
35MP0010307_abnormal_tumor_latency1.67210047
36MP0003119_abnormal_digestive_system1.67016256
37MP0008932_abnormal_embryonic_tissue1.66607535
38MP0000569_abnormal_digit_pigmentation1.62926173
39MP0009703_decreased_birth_body1.62774355
40MP0009672_abnormal_birth_weight1.62032574
41MP0008007_abnormal_cellular_replicative1.58539965
42MP0003385_abnormal_body_wall1.54182346
43MP0003787_abnormal_imprinting1.52997272
44MP0000428_abnormal_craniofacial_morphol1.51019951
45MP0003935_abnormal_craniofacial_develop1.49332177
46MP0003937_abnormal_limbs/digits/tail_de1.49188923
47MP0002080_prenatal_lethality1.48252006
48MP0004808_abnormal_hematopoietic_stem1.39548361
49MP0002396_abnormal_hematopoietic_system1.37586109
50MP0000733_abnormal_muscle_development1.36966844
51MP0003115_abnormal_respiratory_system1.33982561
52MP0001346_abnormal_lacrimal_gland1.31273935
53MP0005409_darkened_coat_color1.29226289
54MP0001849_ear_inflammation1.28146932
55MP0006054_spinal_hemorrhage1.26246381
56MP0003755_abnormal_palate_morphology1.23509271
57MP0003283_abnormal_digestive_organ1.21766500
58MP0002877_abnormal_melanocyte_morpholog1.21497003
59MP0009379_abnormal_foot_pigmentation1.20826478
60MP0005248_abnormal_Harderian_gland1.19851764
61MP0003942_abnormal_urinary_system1.19493244
62MP0000432_abnormal_head_morphology1.18768160
63MP0008058_abnormal_DNA_repair1.18373996
64MP0002092_abnormal_eye_morphology1.16815397
65MP0002697_abnormal_eye_size1.14949875
66MP0002796_impaired_skin_barrier1.14439030
67MP0003861_abnormal_nervous_system1.13348521
68MP0002925_abnormal_cardiovascular_devel1.11012199
69MP0009278_abnormal_bone_marrow1.10647013
70MP0000534_abnormal_ureter_morphology1.10297181
71MP0005623_abnormal_meninges_morphology1.10108284
72MP0002249_abnormal_larynx_morphology1.10107469
73MP0002089_abnormal_postnatal_growth/wei1.09353262
74MP0001286_abnormal_eye_development1.07379584
75MP0010678_abnormal_skin_adnexa1.07113810
76MP0003300_gastrointestinal_ulcer1.06931623
77MP0002938_white_spotting1.06915948
78MP0005367_renal/urinary_system_phenotyp1.06567107
79MP0000516_abnormal_urinary_system1.06567107
80MP0009697_abnormal_copulation1.04062738
81MP0009250_abnormal_appendicular_skeleto1.03701723
82MP0002932_abnormal_joint_morphology1.03593548
83MP0000678_abnormal_parathyroid_gland0.99620082
84MP0008877_abnormal_DNA_methylation0.99132336
85MP0002116_abnormal_craniofacial_bone0.98019604
86MP0000049_abnormal_middle_ear0.97246329
87MP0002653_abnormal_ependyma_morphology0.96850275
88MP0002111_abnormal_tail_morphology0.96185838
89MP0003315_abnormal_perineum_morphology0.95896308
90MP0004264_abnormal_extraembryonic_tissu0.95614827
91MP0003941_abnormal_skin_development0.93903842
92MP0002233_abnormal_nose_morphology0.93838599
93MP0003943_abnormal_hepatobiliary_system0.93553091
94MP0000703_abnormal_thymus_morphology0.93388168
95MP0010630_abnormal_cardiac_muscle0.93326602
96MP0005501_abnormal_skin_physiology0.93221919
97MP0008789_abnormal_olfactory_epithelium0.91928339
98MP0001188_hyperpigmentation0.91627953
99MP0004858_abnormal_nervous_system0.90355474
100MP0000490_abnormal_crypts_of0.89373600
101MP0005621_abnormal_cell_physiology0.89254604
102MP0002081_perinatal_lethality0.87873176
103MP0000383_abnormal_hair_follicle0.86790099
104MP0004233_abnormal_muscle_weight0.86258153
105MP0006292_abnormal_olfactory_placode0.84136636
106MP0001915_intracranial_hemorrhage0.83628096
107MP0000313_abnormal_cell_death0.83198822
108MP0005666_abnormal_adipose_tissue0.83159062
109MP0003303_peritoneal_inflammation0.83021038
110MP0002114_abnormal_axial_skeleton0.82334685
111MP0000579_abnormal_nail_morphology0.80001627
112MP0002282_abnormal_trachea_morphology0.79036763
113MP0003453_abnormal_keratinocyte_physiol0.78205453
114MP0000266_abnormal_heart_morphology0.76684590
115MP0008770_decreased_survivor_rate0.76338014
116MP0001784_abnormal_fluid_regulation0.75547546
117MP0001348_abnormal_lacrimal_gland0.74516661
118MP0005384_cellular_phenotype0.74131378
119MP0003566_abnormal_cell_adhesion0.73926852
120MP0002234_abnormal_pharynx_morphology0.73895167
121MP0000762_abnormal_tongue_morphology0.72338523
122MP0002019_abnormal_tumor_incidence0.70711018
123MP0003938_abnormal_ear_development0.70169037
124MP0002109_abnormal_limb_morphology0.69723884
125MP0001340_abnormal_eyelid_morphology0.68897762

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.16271262
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.08314659
3Short 4th metacarpal (HP:0010044)4.08314659
4Increased nuchal translucency (HP:0010880)3.42899934
5Colon cancer (HP:0003003)3.34740658
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15754112
7Chromsome breakage (HP:0040012)3.13115760
8Abnormality of the 4th metacarpal (HP:0010012)3.12573589
9Renal duplication (HP:0000075)2.97067746
10Medulloblastoma (HP:0002885)2.79045482
11Proximal placement of thumb (HP:0009623)2.77095472
12Rectal prolapse (HP:0002035)2.74994523
13Ependymoma (HP:0002888)2.72397237
14Cortical dysplasia (HP:0002539)2.69807222
15Overlapping toe (HP:0001845)2.68460312
16Deviation of the thumb (HP:0009603)2.68079220
17Insomnia (HP:0100785)2.67678259
18Hyperacusis (HP:0010780)2.66944539
19Long eyelashes (HP:0000527)2.61381321
20Macroorchidism (HP:0000053)2.54227764
21Abnormality of the astrocytes (HP:0100707)2.53452526
22Astrocytoma (HP:0009592)2.53452526
23Nephroblastoma (Wilms tumor) (HP:0002667)2.52926070
24Atresia of the external auditory canal (HP:0000413)2.52075590
25Abnormality of the fingertips (HP:0001211)2.51300429
26High anterior hairline (HP:0009890)2.40860943
27Rhabdomyosarcoma (HP:0002859)2.37669192
28Birth length less than 3rd percentile (HP:0003561)2.36925627
29Embryonal renal neoplasm (HP:0011794)2.34434389
30Abnormal number of incisors (HP:0011064)2.34144889
31Shallow orbits (HP:0000586)2.33365603
32Obsessive-compulsive behavior (HP:0000722)2.33273803
33Supernumerary ribs (HP:0005815)2.30343007
34Abnormality of the labia minora (HP:0012880)2.28911356
35Neoplasm of striated muscle (HP:0009728)2.27148839
36Ankyloglossia (HP:0010296)2.26202984
37Malignant gastrointestinal tract tumors (HP:0006749)2.26194639
38Gastrointestinal carcinoma (HP:0002672)2.26194639
39Acute lymphatic leukemia (HP:0006721)2.25749816
40Broad thumb (HP:0011304)2.23190114
41Biliary tract neoplasm (HP:0100574)2.23101291
42Abnormality of cochlea (HP:0000375)2.22733768
43Pseudobulbar signs (HP:0002200)2.19368935
44Selective tooth agenesis (HP:0001592)2.18944926
45Renovascular hypertension (HP:0100817)2.17660162
46Disproportionate tall stature (HP:0001519)2.17524933
47Neoplasm of the oral cavity (HP:0100649)2.14816251
48Elfin facies (HP:0004428)2.14182661
49Trigonocephaly (HP:0000243)2.13191685
50Cutis marmorata (HP:0000965)2.12936487
51Subacute progressive viral hepatitis (HP:0006572)2.12847834
52Facial hemangioma (HP:0000329)2.11508022
53Glioma (HP:0009733)2.10439439
54Arnold-Chiari malformation (HP:0002308)2.07460381
55Reticulocytopenia (HP:0001896)2.07305326
56Skin tags (HP:0010609)2.07291957
57Overriding aorta (HP:0002623)2.05057353
58Sacral dimple (HP:0000960)2.04975880
59Supernumerary bones of the axial skeleton (HP:0009144)2.04778074
60Pelvic girdle muscle weakness (HP:0003749)2.04431032
61Acute myeloid leukemia (HP:0004808)2.04380789
62Vertebral arch anomaly (HP:0008438)2.04068543
63Prominent nose (HP:0000448)2.02523377
64Truncal obesity (HP:0001956)2.01753723
65Abnormality of the calcaneus (HP:0008364)2.01560786
66Deep palmar crease (HP:0006191)2.00819265
67Narrow palate (HP:0000189)1.98691622
68Hepatoblastoma (HP:0002884)1.98333701
69Abnormality of the diencephalon (HP:0010662)1.97415652
70Progressive external ophthalmoplegia (HP:0000590)1.95448140
71Anal stenosis (HP:0002025)1.95149586
72Abnormality of the distal phalanx of the thumb (HP:0009617)1.95088144
73Duplication of thumb phalanx (HP:0009942)1.94966265
74Insidious onset (HP:0003587)1.93099985
75Termporal pattern (HP:0011008)1.93099985
76Increased density of long bones (HP:0006392)1.92692938
77Urethral obstruction (HP:0000796)1.92594525
78Pointed chin (HP:0000307)1.91739632
79Heterotopia (HP:0002282)1.91457993
80Abnormality of oral frenula (HP:0000190)1.90793648
81Multiple enchondromatosis (HP:0005701)1.90551170
82Turricephaly (HP:0000262)1.89584658
83Short middle phalanx of the 5th finger (HP:0004220)1.88618933
84Basal cell carcinoma (HP:0002671)1.88518107
85Skull defect (HP:0001362)1.88320603
86Dysmetric saccades (HP:0000641)1.88151640
87Ectopic kidney (HP:0000086)1.87759283
88Aplasia/Hypoplasia of the sternum (HP:0006714)1.87457325
89Deep philtrum (HP:0002002)1.86086138
90Long palpebral fissure (HP:0000637)1.85988200
91Embryonal neoplasm (HP:0002898)1.85835800
92Progressive muscle weakness (HP:0003323)1.85074516
93Hypoplastic labia majora (HP:0000059)1.84913458
94Broad phalanges of the hand (HP:0009768)1.84531063
95Preauricular skin tag (HP:0000384)1.83306162
96Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83159385
97Intestinal polyp (HP:0005266)1.82701309
98Uterine neoplasm (HP:0010784)1.81963576
99Transitional cell carcinoma of the bladder (HP:0006740)1.81437992
100Cafe-au-lait spot (HP:0000957)1.81415788
101Broad palm (HP:0001169)1.79870038
102Intestinal polyposis (HP:0200008)1.79466997
103Midline defect of the nose (HP:0004122)1.79268892
104Deviation of the hallux (HP:0010051)1.79248104
105Spinal cord lesions (HP:0100561)1.79133885
106Syringomyelia (HP:0003396)1.79133885
107Hallux valgus (HP:0001822)1.77767235
108Oligodactyly (HP:0012165)1.77445839
109Abnormality of abdominal situs (HP:0011620)1.75246569
110Abdominal situs inversus (HP:0003363)1.75246569
111Low anterior hairline (HP:0000294)1.74678053
112Hypoplasia of the maxilla (HP:0000327)1.74551985
113Asymmetry of the thorax (HP:0001555)1.73697979
114Morphological abnormality of the inner ear (HP:0011390)1.73528454
115Shoulder girdle muscle weakness (HP:0003547)1.73246422
116Abnormality of the salivary glands (HP:0010286)1.72960461
117Bladder carcinoma (HP:0002862)1.72757703
118Bladder neoplasm (HP:0009725)1.72757703
119Broad finger (HP:0001500)1.72382458
120Fibrous tissue neoplasm (HP:0012316)1.72128826
121Abnormality of the phalanges of the hallux (HP:0010057)1.71855601
122Missing ribs (HP:0000921)1.71802861
123Leiomyosarcoma (HP:0100243)1.71055686
124Uterine leiomyosarcoma (HP:0002891)1.71055686
125Short phalanx of the thumb (HP:0009660)1.71002217
126High pitched voice (HP:0001620)1.70773971
127Abnormality of chromosome segregation (HP:0002916)1.70701017
128Limited elbow extension (HP:0001377)1.70648310
129Bowel diverticulosis (HP:0005222)1.70469761
130Intestinal fistula (HP:0100819)1.70420613
131Enlarged penis (HP:0000040)1.70296823
132Patellar dislocation (HP:0002999)1.70111630
133Abnormality of the parietal bone (HP:0002696)1.69611220
134Increased number of teeth (HP:0011069)1.69456422
135Bowel incontinence (HP:0002607)1.68799826
136Metaphyseal cupping (HP:0003021)1.68617563
137Smooth philtrum (HP:0000319)1.67851395
138Intestinal malrotation (HP:0002566)1.67555251
139Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.67189633
140Short 1st metacarpal (HP:0010034)1.67189633
14111 pairs of ribs (HP:0000878)1.66912798
142Orthostatic hypotension (HP:0001278)1.66487233
143Relative macrocephaly (HP:0004482)1.66243194
144Ulnar bowing (HP:0003031)1.65659979
145Radioulnar synostosis (HP:0002974)1.65586376
146Thin ribs (HP:0000883)1.65127279
147Attention deficit hyperactivity disorder (HP:0007018)1.63795733
148Sandal gap (HP:0001852)1.63254175
149Septate vagina (HP:0001153)1.61387004
150Short middle phalanx of finger (HP:0005819)1.61358274
151Aplasia involving bones of the upper limbs (HP:0009823)1.58271998
152Aplasia of the phalanges of the hand (HP:0009802)1.58271998
153Aplasia involving bones of the extremities (HP:0009825)1.58271998
154Spastic diplegia (HP:0001264)1.56560325

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.52692179
2CDK123.92820384
3SMG13.09755562
4NEK22.77235621
5EEF2K2.67473499
6MKNK12.66060593
7MAP3K102.51926420
8PKN22.50000111
9BRD42.40214700
10MKNK22.17840785
11WEE12.16816395
12LATS12.15231615
13CDK62.02232967
14ALK1.98238602
15TAF11.94850941
16PNCK1.92324653
17NEK11.90665552
18SRPK11.90375141
19TRIB31.88194150
20FGFR41.84778950
21TTK1.80354388
22PASK1.74216933
23PRPF4B1.71805596
24SCYL21.68392073
25CDK41.64491290
26RPS6KB21.60910569
27RPS6KA41.46157540
28ATR1.45646686
29TSSK61.44531526
30CAMK1G1.40392379
31PLK31.39569729
32CHEK11.39307793
33PTK61.35767008
34CDK71.28311054
35PDGFRA1.26670427
36FGFR11.24486012
37AURKB1.22542324
38STK101.21250876
39PLK11.20424537
40MTOR1.20022682
41RIPK11.17726079
42ATM1.15933823
43CAMK1D1.14224948
44BRSK21.12460566
45STK241.09203014
46MAP3K81.07101618
47TGFBR11.06978365
48PAK41.06727905
49STK31.06565342
50CDK21.06480250
51ERBB31.06096790
52CHEK21.05856767
53BUB11.05630131
54VRK21.03315947
55LRRK21.02685021
56DYRK30.94554913
57KSR20.92665771
58MAP3K130.91604933
59SIK20.91604504
60MAP3K90.91061620
61CSNK1A1L0.90295158
62MELK0.87641612
63CDK10.86775722
64CSNK1E0.84264840
65SIK10.82077657
66CLK10.80149844
67PAK20.79364895
68EIF2AK10.75812534
69CDK90.73316124
70YES10.72836406
71PRKDC0.71165526
72DMPK0.70756276
73ICK0.70081359
74TYRO30.70023981
75NME20.69566751
76PBK0.68314504
77FGFR30.66646728
78NTRK10.66641347
79LATS20.65795256
80KSR10.65747044
81FGFR20.65196239
82PDGFRB0.65055367
83CSNK1D0.64925192
84ERBB20.64785074
85MAP3K140.63922756
86BRSK10.62016683
87MAPK140.61552172
88CDK30.59845684
89CDK11A0.59185566
90HIPK20.57371457
91EPHB20.55682530
92EIF2AK20.55562619
93CDK150.54472030
94UHMK10.52193964
95BMX0.51698788
96CDK180.51681099
97AKT20.51605659
98GSK3B0.50007747
99ACVR1B0.49372704
100CSNK1G10.47922214
101CDK80.47612686
102TTN0.46764809
103DYRK1B0.46581719
104CSNK2A20.46268706
105AKT10.45233344
106PRKD30.44892931
107MAPK100.44640414
108IRAK30.43794867
109BRAF0.43342219
110CSNK1G30.42465107
111CDK140.41765367
112CSNK1G20.41477406
113PTK20.41060774
114MAPK10.40615419
115AURKA0.40443756
116FRK0.40130807
117DDR20.39684053
118TNIK0.39569404
119PLK40.38852493
120ERBB40.38392217
121STK40.38128746
122MAPK90.36170558
123MAPK80.35929213
124RPS6KB10.35640333
125WNK10.35470410
126CDC42BPA0.34594878
127RET0.32202788

Predicted pathways (KEGG)

RankGene SetZ-score
1* Spliceosome_Homo sapiens_hsa030402.97552635
2DNA replication_Homo sapiens_hsa030302.90045281
3RNA transport_Homo sapiens_hsa030132.79805266
4Cell cycle_Homo sapiens_hsa041102.73877757
5mRNA surveillance pathway_Homo sapiens_hsa030152.64912529
6Mismatch repair_Homo sapiens_hsa034302.57648389
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89856934
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87283547
9One carbon pool by folate_Homo sapiens_hsa006701.81140096
10Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.75411136
11Basal cell carcinoma_Homo sapiens_hsa052171.75229714
12MicroRNAs in cancer_Homo sapiens_hsa052061.73245225
13Colorectal cancer_Homo sapiens_hsa052101.63303128
14Chronic myeloid leukemia_Homo sapiens_hsa052201.60937917
15Oocyte meiosis_Homo sapiens_hsa041141.57620023
16Hippo signaling pathway_Homo sapiens_hsa043901.56954227
17Adherens junction_Homo sapiens_hsa045201.53317675
18Base excision repair_Homo sapiens_hsa034101.50806701
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48954276
20RNA degradation_Homo sapiens_hsa030181.45392578
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45268461
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43080437
23Nucleotide excision repair_Homo sapiens_hsa034201.43011663
24mTOR signaling pathway_Homo sapiens_hsa041501.40522275
25Lysine degradation_Homo sapiens_hsa003101.39164869
26Endometrial cancer_Homo sapiens_hsa052131.38152585
27Biosynthesis of amino acids_Homo sapiens_hsa012301.33631882
28Thyroid cancer_Homo sapiens_hsa052161.32698729
29HTLV-I infection_Homo sapiens_hsa051661.31003496
30Ribosome_Homo sapiens_hsa030101.30330858
31Homologous recombination_Homo sapiens_hsa034401.29704910
32Small cell lung cancer_Homo sapiens_hsa052221.28227083
33Hedgehog signaling pathway_Homo sapiens_hsa043401.27285545
34Wnt signaling pathway_Homo sapiens_hsa043101.24304864
35Non-homologous end-joining_Homo sapiens_hsa034501.24220283
36Proteoglycans in cancer_Homo sapiens_hsa052051.23729556
37Fanconi anemia pathway_Homo sapiens_hsa034601.22995731
38TGF-beta signaling pathway_Homo sapiens_hsa043501.22605823
39p53 signaling pathway_Homo sapiens_hsa041151.22240861
40Prostate cancer_Homo sapiens_hsa052151.20687562
41Non-small cell lung cancer_Homo sapiens_hsa052231.18200023
42Glioma_Homo sapiens_hsa052141.12724583
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12194249
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10373345
45Viral carcinogenesis_Homo sapiens_hsa052031.04543524
46Notch signaling pathway_Homo sapiens_hsa043301.02705664
47Antigen processing and presentation_Homo sapiens_hsa046121.02198049
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01028494
49Viral myocarditis_Homo sapiens_hsa054161.00435954
50Renal cell carcinoma_Homo sapiens_hsa052110.96678225
51Pancreatic cancer_Homo sapiens_hsa052120.95052304
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94253171
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.94195776
54Prion diseases_Homo sapiens_hsa050200.94099628
55Bladder cancer_Homo sapiens_hsa052190.93610793
56Pathways in cancer_Homo sapiens_hsa052000.91490366
57Estrogen signaling pathway_Homo sapiens_hsa049150.89332705
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.89316940
59Epstein-Barr virus infection_Homo sapiens_hsa051690.87450358
60Herpes simplex infection_Homo sapiens_hsa051680.87260503
61Hepatitis B_Homo sapiens_hsa051610.86092129
62Tight junction_Homo sapiens_hsa045300.81035002
63Focal adhesion_Homo sapiens_hsa045100.78570001
64Pentose phosphate pathway_Homo sapiens_hsa000300.77932290
65Melanogenesis_Homo sapiens_hsa049160.77300095
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76675504
67FoxO signaling pathway_Homo sapiens_hsa040680.76381654
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75920066
69Dorso-ventral axis formation_Homo sapiens_hsa043200.74699971
70Acute myeloid leukemia_Homo sapiens_hsa052210.74432157
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.73509133
72Choline metabolism in cancer_Homo sapiens_hsa052310.73476997
73Long-term potentiation_Homo sapiens_hsa047200.73230186
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72474491
75VEGF signaling pathway_Homo sapiens_hsa043700.71569246
76Melanoma_Homo sapiens_hsa052180.71003123
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.70493594
78T cell receptor signaling pathway_Homo sapiens_hsa046600.69173094
79Carbon metabolism_Homo sapiens_hsa012000.67334145
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66890016
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66539763
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66247920
83ErbB signaling pathway_Homo sapiens_hsa040120.63807812
84Basal transcription factors_Homo sapiens_hsa030220.60203275
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60051975
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58410976
87Rap1 signaling pathway_Homo sapiens_hsa040150.58161318
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57817657
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57581158
90Type II diabetes mellitus_Homo sapiens_hsa049300.57467012
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54849023
92Platelet activation_Homo sapiens_hsa046110.53777749
93Gap junction_Homo sapiens_hsa045400.53678962
94HIF-1 signaling pathway_Homo sapiens_hsa040660.53505389
95Axon guidance_Homo sapiens_hsa043600.53058453
96AMPK signaling pathway_Homo sapiens_hsa041520.52727032
97Insulin signaling pathway_Homo sapiens_hsa049100.52267437
98B cell receptor signaling pathway_Homo sapiens_hsa046620.52066909
99Prolactin signaling pathway_Homo sapiens_hsa049170.49527943
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47481127
101Apoptosis_Homo sapiens_hsa042100.47319454
102Glucagon signaling pathway_Homo sapiens_hsa049220.47156801
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46786234
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46724394
105Selenocompound metabolism_Homo sapiens_hsa004500.46580176
106MAPK signaling pathway_Homo sapiens_hsa040100.45744660
107Dopaminergic synapse_Homo sapiens_hsa047280.43997732
108Thyroid hormone synthesis_Homo sapiens_hsa049180.42618832
109Vitamin B6 metabolism_Homo sapiens_hsa007500.41100480
110Insulin resistance_Homo sapiens_hsa049310.40853837
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40027314
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.39830044
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39279363
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39001823
115Pyruvate metabolism_Homo sapiens_hsa006200.38960862
116Pyrimidine metabolism_Homo sapiens_hsa002400.38956629
117GnRH signaling pathway_Homo sapiens_hsa049120.38891917
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38855298
119Fructose and mannose metabolism_Homo sapiens_hsa000510.38223049
120Inositol phosphate metabolism_Homo sapiens_hsa005620.34706238
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34200254

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