HNRNPA3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.16359546
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.61667636
3ATP synthesis coupled proton transport (GO:0015986)5.61667636
4protein neddylation (GO:0045116)5.33037564
5chaperone-mediated protein transport (GO:0072321)5.27097958
6viral transcription (GO:0019083)4.97488839
7ribosomal small subunit assembly (GO:0000028)4.97208956
8translational termination (GO:0006415)4.84851092
9maturation of SSU-rRNA (GO:0030490)4.72949021
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.60580465
11ribosomal small subunit biogenesis (GO:0042274)4.59724981
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.41529522
13respiratory electron transport chain (GO:0022904)4.38848070
14electron transport chain (GO:0022900)4.32837441
15behavioral response to nicotine (GO:0035095)4.26573333
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.22590976
17cotranslational protein targeting to membrane (GO:0006613)4.16798691
18ribosomal large subunit biogenesis (GO:0042273)4.15760442
19protein targeting to ER (GO:0045047)4.14871940
20water-soluble vitamin biosynthetic process (GO:0042364)4.11359088
21negative regulation of DNA-dependent DNA replication (GO:2000104)4.09966154
22regulation of nuclear cell cycle DNA replication (GO:0033262)4.08738331
23translational elongation (GO:0006414)4.06588795
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.94683725
25protein polyglutamylation (GO:0018095)3.92741330
26establishment of integrated proviral latency (GO:0075713)3.87113509
27protein localization to endoplasmic reticulum (GO:0070972)3.86474958
28peptidyl-threonine dephosphorylation (GO:0035970)3.84092493
29translational initiation (GO:0006413)3.79978609
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.79952041
31negative regulation of telomerase activity (GO:0051974)3.77852877
32DNA strand renaturation (GO:0000733)3.74219629
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.65104812
34NADH dehydrogenase complex assembly (GO:0010257)3.65104812
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65104812
36cellular protein complex disassembly (GO:0043624)3.64016487
37rRNA modification (GO:0000154)3.62506811
38viral life cycle (GO:0019058)3.59936614
39proteasome assembly (GO:0043248)3.55882786
40spliceosomal snRNP assembly (GO:0000387)3.53771038
41translation (GO:0006412)3.50115233
42replication fork processing (GO:0031297)3.49049956
43intra-S DNA damage checkpoint (GO:0031573)3.45994572
44DNA damage response, detection of DNA damage (GO:0042769)3.32728389
45protein complex disassembly (GO:0043241)3.31736504
46protein complex biogenesis (GO:0070271)3.27345306
47hydrogen ion transmembrane transport (GO:1902600)3.22274664
48ribonucleoprotein complex biogenesis (GO:0022613)3.19772076
49mitochondrial respiratory chain complex assembly (GO:0033108)3.19273691
50macromolecular complex disassembly (GO:0032984)3.18866408
51ATP biosynthetic process (GO:0006754)3.17544654
52chromatin remodeling at centromere (GO:0031055)3.14624443
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.14156870
54respiratory chain complex IV assembly (GO:0008535)3.13447196
55termination of RNA polymerase III transcription (GO:0006386)3.13386751
56transcription elongation from RNA polymerase III promoter (GO:0006385)3.13386751
57formation of translation preinitiation complex (GO:0001731)3.12226261
58purine nucleoside triphosphate biosynthetic process (GO:0009145)3.09447883
59regulation of helicase activity (GO:0051095)3.08493636
60cellular component biogenesis (GO:0044085)3.06034191
61telomere maintenance via telomerase (GO:0007004)3.05500697
62inner mitochondrial membrane organization (GO:0007007)3.03949533
63GTP biosynthetic process (GO:0006183)3.03428886
64spliceosomal complex assembly (GO:0000245)3.02411205
65purine nucleobase biosynthetic process (GO:0009113)2.96857800
66pseudouridine synthesis (GO:0001522)2.95260134
67aldehyde catabolic process (GO:0046185)2.92425137
68maturation of 5.8S rRNA (GO:0000460)2.89052457
69DNA replication checkpoint (GO:0000076)2.86818538
70RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.86299394
71tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.86299394
72positive regulation of immune response to tumor cell (GO:0002839)2.85827210
73regulation of immune response to tumor cell (GO:0002837)2.85827210
74regulation of response to tumor cell (GO:0002834)2.85827210
75positive regulation of response to tumor cell (GO:0002836)2.85827210
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84865631
77CENP-A containing nucleosome assembly (GO:0034080)2.83538537
78oxidative phosphorylation (GO:0006119)2.83326849
79proton transport (GO:0015992)2.81332939
80rRNA processing (GO:0006364)2.81001465
81glyoxylate metabolic process (GO:0046487)2.80893412
82platelet dense granule organization (GO:0060155)2.79146630
83hydrogen transport (GO:0006818)2.78533882
84nuclear-transcribed mRNA catabolic process (GO:0000956)2.76918263
85ribonucleoside triphosphate biosynthetic process (GO:0009201)2.74211511
86rRNA metabolic process (GO:0016072)2.72560479
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72302288
88cytochrome complex assembly (GO:0017004)2.72050239
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71097529
90tongue development (GO:0043586)2.70781125
91establishment of viral latency (GO:0019043)2.69940394
92protein targeting to membrane (GO:0006612)2.69315685
93regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.69271626
94regulation of protein polyubiquitination (GO:1902914)2.65153023
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64950555
96aerobic respiration (GO:0009060)2.58348884
97detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58280616
98mRNA catabolic process (GO:0006402)2.57907844
99cellular hyperosmotic response (GO:0071474)2.57272535
100regulation of telomerase activity (GO:0051972)2.57173255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.00075028
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.84277152
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.68463633
4EZH2_22144423_ChIP-Seq_EOC_Human3.26122082
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11341505
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02306418
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96586719
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.95205695
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.81371953
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66593449
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62001882
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.59606131
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58248156
14VDR_22108803_ChIP-Seq_LS180_Human2.38257515
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30528898
16IGF1R_20145208_ChIP-Seq_DFB_Human2.27827894
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20886840
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20745005
19ESR1_15608294_ChIP-ChIP_MCF-7_Human2.15068148
20ELK1_19687146_ChIP-ChIP_HELA_Human2.13541213
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12031120
22ZNF274_21170338_ChIP-Seq_K562_Hela2.08788668
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.00964825
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00154098
25TTF2_22483619_ChIP-Seq_HELA_Human2.00148348
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.98879657
27VDR_23849224_ChIP-Seq_CD4+_Human1.95263759
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91276198
29MYC_18940864_ChIP-ChIP_HL60_Human1.82122040
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75480709
31E2F7_22180533_ChIP-Seq_HELA_Human1.75354499
32FOXP3_21729870_ChIP-Seq_TREG_Human1.75013578
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68686621
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63307805
35SOX2_16153702_ChIP-ChIP_HESCs_Human1.61554134
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57500281
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55863273
38EWS_26573619_Chip-Seq_HEK293_Human1.55116314
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51959791
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51667792
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50615205
42XRN2_22483619_ChIP-Seq_HELA_Human1.45930856
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43868450
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43003709
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41029459
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37339736
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34608963
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31372774
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.29648623
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.29578921
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28695235
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.26610342
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.24630652
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24066343
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23556435
56SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21661615
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20772791
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17890092
59TP53_22573176_ChIP-Seq_HFKS_Human1.17552224
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17330864
61TAF15_26573619_Chip-Seq_HEK293_Human1.17208679
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15847621
63FUS_26573619_Chip-Seq_HEK293_Human1.15641531
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13781200
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13607015
66DCP1A_22483619_ChIP-Seq_HELA_Human1.12328694
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.10488478
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09047546
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08714318
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07395157
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07121240
72GABP_19822575_ChIP-Seq_HepG2_Human1.06426916
73IRF1_19129219_ChIP-ChIP_H3396_Human1.05895677
74CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05633899
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05289009
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03408249
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02328126
78RNF2_27304074_Chip-Seq_NSC_Mouse1.02205167
79ERA_21632823_ChIP-Seq_H3396_Human0.98788959
80CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98486232
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98286000
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98151973
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.97209062
84SRF_21415370_ChIP-Seq_HL-1_Mouse0.95934794
85REST_21632747_ChIP-Seq_MESCs_Mouse0.94485181
86LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93445092
87EZH2_27304074_Chip-Seq_ESCs_Mouse0.91343456
88NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89746848
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89338635
90E2F1_20622854_ChIP-Seq_HELA_Human0.88447832
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87610369
92* P300_19829295_ChIP-Seq_ESCs_Human0.87075248
93NANOG_20526341_ChIP-Seq_ESCs_Human0.86103551
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.85610489
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85610489
96CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84685676
97MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84632404
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.84592009
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.81907871
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80635148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.19344009
2MP0006292_abnormal_olfactory_placode3.11700322
3MP0008877_abnormal_DNA_methylation3.06708417
4MP0009384_cardiac_valve_regurgitation3.02729537
5MP0005377_hearing/vestibular/ear_phenot2.95944479
6MP0003878_abnormal_ear_physiology2.95944479
7MP0001485_abnormal_pinna_reflex2.83410679
8MP0003315_abnormal_perineum_morphology2.57345759
9MP0002163_abnormal_gland_morphology2.56146801
10MP0009379_abnormal_foot_pigmentation2.49501531
11MP0004885_abnormal_endolymph2.43627672
12MP0006072_abnormal_retinal_apoptosis2.36916196
13MP0005645_abnormal_hypothalamus_physiol2.27949516
14MP0008789_abnormal_olfactory_epithelium2.13473228
15MP0002160_abnormal_reproductive_system2.13473183
16MP0008058_abnormal_DNA_repair2.01730981
17MP0003787_abnormal_imprinting2.00736789
18MP0004957_abnormal_blastocyst_morpholog1.87838309
19MP0003195_calcinosis1.81968309
20MP0003136_yellow_coat_color1.81224811
21MP0001293_anophthalmia1.79888280
22MP0002277_abnormal_respiratory_mucosa1.79386839
23MP0004145_abnormal_muscle_electrophysio1.70820279
24MP0003567_abnormal_fetal_cardiomyocyte1.70760447
25MP0005379_endocrine/exocrine_gland_phen1.68005191
26MP0002653_abnormal_ependyma_morphology1.66770540
27MP0000049_abnormal_middle_ear1.63629916
28MP0001919_abnormal_reproductive_system1.63060758
29MP0005389_reproductive_system_phenotype1.61932721
30MP0003119_abnormal_digestive_system1.60051502
31MP0004142_abnormal_muscle_tone1.53705134
32MP0004043_abnormal_pH_regulation1.46441857
33MP0001529_abnormal_vocalization1.44756519
34MP0001968_abnormal_touch/_nociception1.43537730
35MP0003786_premature_aging1.43421984
36MP0002736_abnormal_nociception_after1.43326171
37MP0000631_abnormal_neuroendocrine_gland1.40462462
38MP0003941_abnormal_skin_development1.38834551
39MP0005394_taste/olfaction_phenotype1.37751627
40MP0005499_abnormal_olfactory_system1.37751627
41MP0010094_abnormal_chromosome_stability1.33948386
42MP0005551_abnormal_eye_electrophysiolog1.33532509
43MP0008872_abnormal_physiological_respon1.32504877
44MP0008995_early_reproductive_senescence1.32248028
45MP0002638_abnormal_pupillary_reflex1.29128094
46MP0003111_abnormal_nucleus_morphology1.28904890
47MP0001188_hyperpigmentation1.25689929
48MP0003122_maternal_imprinting1.24641206
49MP0008932_abnormal_embryonic_tissue1.24515287
50MP0003937_abnormal_limbs/digits/tail_de1.23736746
51MP0002822_catalepsy1.13857833
52MP0003936_abnormal_reproductive_system1.13552472
53MP0000778_abnormal_nervous_system1.13379894
54MP0001881_abnormal_mammary_gland1.11999771
55MP0002102_abnormal_ear_morphology1.10520803
56MP0002557_abnormal_social/conspecific_i1.09880171
57MP0001727_abnormal_embryo_implantation1.06281650
58MP0003011_delayed_dark_adaptation1.05161684
59MP0004742_abnormal_vestibular_system1.04459451
60MP0001440_abnormal_grooming_behavior1.00409473
61MP0003718_maternal_effect1.00336249
62MP0005195_abnormal_posterior_eye1.00292595
63MP0004133_heterotaxia0.98925133
64MP0008007_abnormal_cellular_replicative0.97823237
65MP0003890_abnormal_embryonic-extraembry0.97788525
66MP0003121_genomic_imprinting0.96423370
67MP0002938_white_spotting0.95720443
68MP0001963_abnormal_hearing_physiology0.95642543
69MP0002184_abnormal_innervation0.93598880
70MP0002210_abnormal_sex_determination0.93281091
71MP0005253_abnormal_eye_physiology0.91629390
72MP0001286_abnormal_eye_development0.91257485
73MP0002752_abnormal_somatic_nervous0.89910094
74MP0003186_abnormal_redox_activity0.86082791
75MP0008875_abnormal_xenobiotic_pharmacok0.85978000
76MP0001905_abnormal_dopamine_level0.84693509
77MP0005187_abnormal_penis_morphology0.84535519
78MP0000427_abnormal_hair_cycle0.83197111
79MP0002572_abnormal_emotion/affect_behav0.83063750
80MP0002735_abnormal_chemical_nociception0.82275880
81MP0005671_abnormal_response_to0.81994923
82MP0000372_irregular_coat_pigmentation0.81518505
83MP0001346_abnormal_lacrimal_gland0.81173514
84MP0005084_abnormal_gallbladder_morpholo0.79815549
85MP0001145_abnormal_male_reproductive0.78806222
86MP0000627_abnormal_mammary_gland0.76302365
87MP0000579_abnormal_nail_morphology0.75515191
88MP0002733_abnormal_thermal_nociception0.73503519
89MP0004215_abnormal_myocardial_fiber0.72675799
90MP0009745_abnormal_behavioral_response0.72433323
91MP0000653_abnormal_sex_gland0.71993176
92MP0001502_abnormal_circadian_rhythm0.71471165
93MP0002272_abnormal_nervous_system0.71356272
94MP0001119_abnormal_female_reproductive0.70808643
95MP0003638_abnormal_response/metabolism_0.68736659
96MP0008770_decreased_survivor_rate0.68494528
97MP0001299_abnormal_eye_distance/0.66279476
98MP0001929_abnormal_gametogenesis0.66090573
99MP0001486_abnormal_startle_reflex0.65491500
100MP0003698_abnormal_male_reproductive0.63906555

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.62261708
2Acute encephalopathy (HP:0006846)3.99855725
3Progressive macrocephaly (HP:0004481)3.86556192
4Colon cancer (HP:0003003)3.79873712
5Abnormal mitochondria in muscle tissue (HP:0008316)3.77728622
6Pancreatic fibrosis (HP:0100732)3.48917621
7Mitochondrial inheritance (HP:0001427)3.47586916
8Increased hepatocellular lipid droplets (HP:0006565)3.38042967
9Reticulocytopenia (HP:0001896)3.37155414
10Nephronophthisis (HP:0000090)3.20961945
11Lipid accumulation in hepatocytes (HP:0006561)3.11606367
12Septo-optic dysplasia (HP:0100842)3.07905720
13Increased CSF lactate (HP:0002490)3.03684120
14Pendular nystagmus (HP:0012043)3.00913968
15Bile duct proliferation (HP:0001408)2.96026902
16Abnormal biliary tract physiology (HP:0012439)2.96026902
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.94939624
18Abnormality of alanine metabolism (HP:0010916)2.94939624
19Hyperalaninemia (HP:0003348)2.94939624
20Absent septum pellucidum (HP:0001331)2.94675801
21Abnormality of the septum pellucidum (HP:0007375)2.88559909
22Macrocytic anemia (HP:0001972)2.86882030
23Congenital, generalized hypertrichosis (HP:0004540)2.84671973
24Cerebral edema (HP:0002181)2.78775603
25Cellular immunodeficiency (HP:0005374)2.78341183
26Pancreatic cysts (HP:0001737)2.77924431
27True hermaphroditism (HP:0010459)2.77273162
28Hepatocellular necrosis (HP:0001404)2.75759356
29Abnormality of the anterior horn cell (HP:0006802)2.71637805
30Degeneration of anterior horn cells (HP:0002398)2.71637805
31Chronic bronchitis (HP:0004469)2.65547218
32Absent/shortened dynein arms (HP:0200106)2.64717293
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.64717293
34Abnormality of the renal medulla (HP:0100957)2.54983745
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.52191500
36Abnormality of cells of the erythroid lineage (HP:0012130)2.47891433
37Supernumerary spleens (HP:0009799)2.42657934
38Optic disc pallor (HP:0000543)2.41618853
39Renal Fanconi syndrome (HP:0001994)2.39698754
40Maternal diabetes (HP:0009800)2.37198157
41Rib fusion (HP:0000902)2.36335314
42Hepatic necrosis (HP:0002605)2.36092235
43Congenital stationary night blindness (HP:0007642)2.32900504
44Exertional dyspnea (HP:0002875)2.32402986
45Neoplasm of the adrenal cortex (HP:0100641)2.31102835
46Abnormal number of incisors (HP:0011064)2.29910473
47Absent thumb (HP:0009777)2.28248405
48Abolished electroretinogram (ERG) (HP:0000550)2.26046388
49Aplasia/Hypoplasia of the spleen (HP:0010451)2.25392589
50Asplenia (HP:0001746)2.22713763
51Spinal muscular atrophy (HP:0007269)2.21987879
52Horseshoe kidney (HP:0000085)2.21741324
53Sclerocornea (HP:0000647)2.20637567
54Increased serum lactate (HP:0002151)2.12194920
55Confusion (HP:0001289)2.10084732
56Lactic acidosis (HP:0003128)2.06874009
57Dandy-Walker malformation (HP:0001305)2.06302554
58Abnormal number of erythroid precursors (HP:0012131)2.03841830
59Reduced antithrombin III activity (HP:0001976)2.03424623
60Ectopic kidney (HP:0000086)2.00783707
61Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00294951
62Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99879722
63Leukodystrophy (HP:0002415)1.98729318
64Pallor (HP:0000980)1.95408499
65Inability to walk (HP:0002540)1.94884995
66Molar tooth sign on MRI (HP:0002419)1.92470426
67Abnormality of midbrain morphology (HP:0002418)1.92470426
68Respiratory failure (HP:0002878)1.89728279
69Parakeratosis (HP:0001036)1.89383705
70Abnormality of renal resorption (HP:0011038)1.88412803
71Keratoconus (HP:0000563)1.88193502
72Increased corneal curvature (HP:0100692)1.88193502
73Anencephaly (HP:0002323)1.87717169
74Neoplasm of the adrenal gland (HP:0100631)1.85769510
75Abnormal rod and cone electroretinograms (HP:0008323)1.85535455
76Abnormality of serum amino acid levels (HP:0003112)1.80416499
77Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80272706
78Respiratory difficulties (HP:0002880)1.80077564
79Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79180301
80Fatigable weakness (HP:0003473)1.78548236
81Abnormality of the neuromuscular junction (HP:0003398)1.78548236
82Hyperglycinemia (HP:0002154)1.78288201
83Deformed tarsal bones (HP:0008119)1.78218247
84Increased intramyocellular lipid droplets (HP:0012240)1.75873592
85Decreased central vision (HP:0007663)1.75635065
86Aplasia/Hypoplasia of the patella (HP:0006498)1.74038519
87Oral leukoplakia (HP:0002745)1.73579342
88Abnormality of the ileum (HP:0001549)1.73314729
89Abnormal drinking behavior (HP:0030082)1.67910702
90Polydipsia (HP:0001959)1.67910702
91Patellar aplasia (HP:0006443)1.67738032
92Abnormality of DNA repair (HP:0003254)1.67476612
93Type 2 muscle fiber atrophy (HP:0003554)1.66971827
94Exercise intolerance (HP:0003546)1.66934120
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.66692105
96Male pseudohermaphroditism (HP:0000037)1.66502798
97Abnormality of abdominal situs (HP:0011620)1.64031116
98Abdominal situs inversus (HP:0003363)1.64031116
99Depressed nasal tip (HP:0000437)1.62993516
100Palpebral edema (HP:0100540)1.62468047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.08641073
2MUSK4.48546171
3VRK24.17290070
4ZAK3.58834027
5TNIK3.17027826
6WNK42.93665844
7NME12.83207067
8NUAK12.78560125
9TAF12.76430229
10CDC72.62016719
11VRK12.30150426
12SRPK12.23672479
13BCR2.21165834
14TXK2.01084039
15CDK191.76938826
16MKNK21.67653595
17PLK31.66103819
18PBK1.65840607
19MAP4K21.48895841
20DYRK21.42183137
21MKNK11.39921521
22DYRK31.27289551
23NEK21.23684134
24PINK11.23384880
25ADRBK21.21838105
26CASK1.21216525
27LATS11.17254656
28STK161.15155127
29TSSK61.07279662
30PLK11.05272467
31CAMK1D1.03780633
32TIE11.02306038
33BMPR1B0.98760725
34SMG10.94844478
35OXSR10.94239913
36STK390.92729608
37GRK10.86878736
38STK30.84395155
39CAMKK20.81509630
40NME20.76984516
41AURKB0.75331236
42NLK0.73662398
43TTK0.72856345
44TLK10.72160056
45DYRK1B0.71530915
46CSNK1G30.71182638
47MST40.70979070
48CAMK1G0.68536501
49CSNK1G10.67798596
50IRAK20.67489260
51PLK40.67407644
52CHEK20.66996445
53CSNK1G20.66096821
54ATR0.65785881
55LIMK10.63754641
56CSNK2A20.62654834
57AKT20.61885030
58CSNK1E0.61222093
59PAK30.58960750
60STK38L0.58888544
61AURKA0.57320045
62EIF2AK30.57002840
63MAPKAPK50.55431602
64CCNB10.54739422
65BUB10.54265831
66STK110.52491404
67PRKCG0.52154096
68CAMK10.49536861
69ALK0.48062004
70RPS6KB20.48001179
71CSNK2A10.47828629
72DAPK30.47488841
73CSNK1A1L0.46043153
74EPHB20.45850297
75FRK0.45609597
76ADRBK10.44552814
77WNK10.43789312
78CHEK10.42537494
79CDK90.42030110
80DYRK1A0.41129501
81RPS6KA40.40999003
82MAP3K40.37096375
83FES0.33615825
84CSNK1A10.32760096
85RPS6KA50.32750847
86WNK30.32496351
87PRKDC0.31939495
88TESK20.31297218
89CSNK1D0.29529746
90PLK20.26061606
91MAP2K70.25730638
92EIF2AK20.25509282
93DAPK20.25218889
94PRKCE0.24297493
95DMPK0.24290623
96PRKD30.24203082
97PRKACA0.23232841
98CDK30.22420585
99ATM0.22365020
100PDK20.22280779

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.03316062
2Oxidative phosphorylation_Homo sapiens_hsa001904.27361747
3Parkinsons disease_Homo sapiens_hsa050123.64258528
4Proteasome_Homo sapiens_hsa030503.46993563
5RNA polymerase_Homo sapiens_hsa030202.86334797
6Huntingtons disease_Homo sapiens_hsa050162.80523467
7Cardiac muscle contraction_Homo sapiens_hsa042602.58068279
8Alzheimers disease_Homo sapiens_hsa050102.51766879
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38619019
10Homologous recombination_Homo sapiens_hsa034402.21162832
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.19722463
12Spliceosome_Homo sapiens_hsa030402.06038146
13Protein export_Homo sapiens_hsa030602.02819846
14Phototransduction_Homo sapiens_hsa047441.87435150
15Basal transcription factors_Homo sapiens_hsa030221.70078931
16Mismatch repair_Homo sapiens_hsa034301.62502132
17Non-homologous end-joining_Homo sapiens_hsa034501.58399489
18Asthma_Homo sapiens_hsa053101.56058262
19DNA replication_Homo sapiens_hsa030301.54899561
20Linoleic acid metabolism_Homo sapiens_hsa005911.54889653
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53962469
22RNA transport_Homo sapiens_hsa030131.52966341
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50969880
24Steroid biosynthesis_Homo sapiens_hsa001001.49173106
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47403751
26Nitrogen metabolism_Homo sapiens_hsa009101.45393603
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42963753
28Purine metabolism_Homo sapiens_hsa002301.32583672
29Nucleotide excision repair_Homo sapiens_hsa034201.29782756
30RNA degradation_Homo sapiens_hsa030181.27506566
31Pyrimidine metabolism_Homo sapiens_hsa002401.26482048
32Base excision repair_Homo sapiens_hsa034101.14420547
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13398173
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08333923
35Sulfur relay system_Homo sapiens_hsa041221.05774845
36Propanoate metabolism_Homo sapiens_hsa006401.05496302
37Fanconi anemia pathway_Homo sapiens_hsa034601.02778313
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01827649
39Pyruvate metabolism_Homo sapiens_hsa006200.99632352
40Fat digestion and absorption_Homo sapiens_hsa049750.97279846
41Ether lipid metabolism_Homo sapiens_hsa005650.96561612
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96388507
43Tryptophan metabolism_Homo sapiens_hsa003800.95655596
44Fatty acid elongation_Homo sapiens_hsa000620.93960643
45Vitamin digestion and absorption_Homo sapiens_hsa049770.87253888
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.85955093
47Systemic lupus erythematosus_Homo sapiens_hsa053220.85429702
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82874216
49Olfactory transduction_Homo sapiens_hsa047400.79067471
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76918960
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76886448
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73970264
53Metabolic pathways_Homo sapiens_hsa011000.67161452
54Butanoate metabolism_Homo sapiens_hsa006500.66310807
55Selenocompound metabolism_Homo sapiens_hsa004500.65014882
56Basal cell carcinoma_Homo sapiens_hsa052170.64944786
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62796856
58Allograft rejection_Homo sapiens_hsa053300.60477113
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60287114
60Retinol metabolism_Homo sapiens_hsa008300.59687455
61Peroxisome_Homo sapiens_hsa041460.58659931
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.58406221
63Sulfur metabolism_Homo sapiens_hsa009200.54394500
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53281668
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52815105
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50645191
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45090026
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44694436
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44235155
70Morphine addiction_Homo sapiens_hsa050320.43304420
71Graft-versus-host disease_Homo sapiens_hsa053320.42702230
72Type I diabetes mellitus_Homo sapiens_hsa049400.41859204
73Autoimmune thyroid disease_Homo sapiens_hsa053200.41589568
74Serotonergic synapse_Homo sapiens_hsa047260.41529423
75Starch and sucrose metabolism_Homo sapiens_hsa005000.40185438
76Glutathione metabolism_Homo sapiens_hsa004800.39460773
77One carbon pool by folate_Homo sapiens_hsa006700.39152241
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38798146
79Arachidonic acid metabolism_Homo sapiens_hsa005900.38729727
80Arginine and proline metabolism_Homo sapiens_hsa003300.37617828
81Alcoholism_Homo sapiens_hsa050340.36136723
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35967563
83Cell cycle_Homo sapiens_hsa041100.34875732
84mRNA surveillance pathway_Homo sapiens_hsa030150.34170638
85Fatty acid degradation_Homo sapiens_hsa000710.33773487
86Chemical carcinogenesis_Homo sapiens_hsa052040.33623776
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30644482
88Thyroid cancer_Homo sapiens_hsa052160.30520072
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29300978
90Wnt signaling pathway_Homo sapiens_hsa043100.27241446
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25489346
92Salivary secretion_Homo sapiens_hsa049700.24684070
93Nicotine addiction_Homo sapiens_hsa050330.23272722
94Epstein-Barr virus infection_Homo sapiens_hsa051690.23125296
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23023748
96Taste transduction_Homo sapiens_hsa047420.21829680
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19442530
98Arginine biosynthesis_Homo sapiens_hsa002200.19019131
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19000444
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.16494367

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