ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sequestering of actin monomers (GO:0042989)	6.56384182
2	proteasome assembly (GO:0043248)	4.98648289
3	DNA deamination (GO:0045006)	4.64382526
4	metallo-sulfur cluster assembly (GO:0031163)	4.58768137
5	iron-sulfur cluster assembly (GO:0016226)	4.58768137
6	DNA double-strand break processing (GO:0000729)	4.41407248
7	gamma-aminobutyric acid transport (GO:0015812)	4.38341688
8	protein complex biogenesis (GO:0070271)	4.27894487
9	respiratory chain complex IV assembly (GO:0008535)	4.27295411
10	indolalkylamine metabolic process (GO:0006586)	4.23208176
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.15651936
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.15651936
13	NADH dehydrogenase complex assembly (GO:0010257)	4.15651936
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.08409008
15	mitochondrial respiratory chain complex assembly (GO:0033108)	4.03393287
16	rRNA modification (GO:0000154)	4.00852771
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.99981733
18	ubiquinone biosynthetic process (GO:0006744)	3.99376584
19	protein neddylation (GO:0045116)	3.93122976
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.90107211
21	cytidine metabolic process (GO:0046087)	3.88744442
22	cytidine catabolic process (GO:0006216)	3.88744442
23	cytidine deamination (GO:0009972)	3.88744442
24	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.75669293
25	ubiquinone metabolic process (GO:0006743)	3.74936899
26	regulation of protein polyubiquitination (GO:1902914)	3.65841958
27	neuron fate determination (GO:0048664)	3.60053767
28	mannosylation (GO:0097502)	3.56779418
29	DNA demethylation (GO:0080111)	3.55429495
30	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.53396931
31	ATP synthesis coupled proton transport (GO:0015986)	3.53396931
32	DNA replication-dependent nucleosome organization (GO:0034723)	3.51536109
33	DNA replication-dependent nucleosome assembly (GO:0006335)	3.51536109
34	peptidyl-histidine modification (GO:0018202)	3.51213456
35	indolalkylamine catabolic process (GO:0046218)	3.47920586
36	tryptophan catabolic process (GO:0006569)	3.47920586
37	indole-containing compound catabolic process (GO:0042436)	3.47920586
38	platelet dense granule organization (GO:0060155)	3.46383533
39	respiratory electron transport chain (GO:0022904)	3.45425173
40	tryptophan metabolic process (GO:0006568)	3.43623971
41	electron transport chain (GO:0022900)	3.41527562
42	regulation of DNA endoreduplication (GO:0032875)	3.37085355
43	cullin deneddylation (GO:0010388)	3.34362154
44	cytochrome complex assembly (GO:0017004)	3.26815054
45	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.26496989
46	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.26197191
47	protein polyglutamylation (GO:0018095)	3.26007611
48	ketone body metabolic process (GO:1902224)	3.21762625
49	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.21525593
50	nonmotile primary cilium assembly (GO:0035058)	3.18696858
51	negative regulation of cell aging (GO:0090344)	3.12341538
52	quinone biosynthetic process (GO:1901663)	3.12193706
53	rRNA methylation (GO:0031167)	3.10248886
54	regulation of acrosome reaction (GO:0060046)	3.08299493
55	cellular ketone body metabolic process (GO:0046950)	3.08216522
56	regulation of cellular amino acid metabolic process (GO:0006521)	3.08139893
57	chaperone-mediated protein transport (GO:0072321)	3.07943568
58	secondary metabolite biosynthetic process (GO:0044550)	3.07819984
59	regulation of memory T cell differentiation (GO:0043380)	3.06961005
60	intra-S DNA damage checkpoint (GO:0031573)	3.06002142
61	sulfation (GO:0051923)	3.05972872
62	indole-containing compound metabolic process (GO:0042430)	3.03566798
63	negative regulation of ligase activity (GO:0051352)	2.99995322
64	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.99995322
65	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.97121951
66	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.97057558
67	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.97057558
68	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.97057558
69	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.97051503
70	microtubule depolymerization (GO:0007019)	2.95423579
71	intraciliary transport (GO:0042073)	2.90742815
72	protein deneddylation (GO:0000338)	2.89132758
73	positive regulation of cell fate commitment (GO:0010455)	2.87194760
74	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.86292122
75	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.86292122
76	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.84108985
77	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.83299380
78	regulation of transcription regulatory region DNA binding (GO:2000677)	2.83295127
79	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.83185915
80	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.83185915
81	DNA catabolic process, exonucleolytic (GO:0000738)	2.81350199
82	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.81328857
83	termination of RNA polymerase III transcription (GO:0006386)	2.81328857
84	behavioral response to nicotine (GO:0035095)	2.80489548
85	DNA dealkylation (GO:0035510)	2.78618873
86	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.65315162
87	replication fork processing (GO:0031297)	2.65202225
88	adaptation of signaling pathway (GO:0023058)	2.62075788
89	GPI anchor metabolic process (GO:0006505)	2.61678400
90	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.59918896
91	amine catabolic process (GO:0009310)	2.59022351
92	cellular biogenic amine catabolic process (GO:0042402)	2.59022351
93	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.57551733
94	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.56953856
95	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.55056556
96	melanin biosynthetic process (GO:0042438)	2.52982923
97	copper ion homeostasis (GO:0055070)	2.52643534
98	aromatic amino acid family metabolic process (GO:0009072)	2.51060095
99	negative regulation of DNA binding (GO:0043392)	2.50253750
100	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.49616759

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.11887822
2	TAF15_26573619_Chip-Seq_HEK293_Human	3.53253848
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.18560792
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.06230044
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.05517946
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.83584541
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.75107192
8	ELK1_19687146_ChIP-ChIP_HELA_Human	2.62362713
9	VDR_22108803_ChIP-Seq_LS180_Human	2.61320071
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.47178257
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.38391084
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.32238836
13	EWS_26573619_Chip-Seq_HEK293_Human	2.30782020
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.27712949
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.27378384
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.11719127
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.05693437
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.04962269
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04158476
20	FUS_26573619_Chip-Seq_HEK293_Human	2.01244775
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.98958471
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.98504288
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.95670847
24	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.93199972
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.86888685
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.84294507
27	P300_19829295_ChIP-Seq_ESCs_Human	1.84157950
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.83003831
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.82731126
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.80115362
31	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.74371628
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.73824508
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.73417285
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.59051255
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.55869405
36	EZH2_22144423_ChIP-Seq_EOC_Human	1.53728001
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.46698723
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.46621574
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.45973214
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45734178
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42933315
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.36850930
43	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.33515415
44	FOXP3_21729870_ChIP-Seq_TREG_Human	1.33513216
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30250037
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30250037
47	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.25845641
48	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.25393319
49	HTT_18923047_ChIP-ChIP_STHdh_Human	1.25388421
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24848188
51	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.24609299
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23865986
53	DCP1A_22483619_ChIP-Seq_HELA_Human	1.22779388
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22567442
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.22555314
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.22555314
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22393960
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22393960
59	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.22355507
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18583109
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18583109
62	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.17803689
63	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.17695445
64	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.16541837
65	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.12968069
66	AR_25329375_ChIP-Seq_VCAP_Human	1.11724035
67	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.11702430
68	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.10796136
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09891966
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.08562143
71	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.08290418
72	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.07101754
73	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.06947734
74	SMAD4_21799915_ChIP-Seq_A2780_Human	1.06881165
75	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.04371942
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04326790
77	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04113956
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03882500
79	NCOR_22424771_ChIP-Seq_293T_Human	1.03282565
80	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.03274455
81	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99814373
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99419275
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98753737
84	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.97122135
85	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.96670125
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96601787
87	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.96081310
88	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96014828
89	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.95605443
90	AR_20517297_ChIP-Seq_VCAP_Human	0.94804101
91	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94716430
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.93880512
93	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.93607228
94	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93448627
95	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.92870307
96	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.92858784
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.92113208
98	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.88730395
99	PHF8_20622853_ChIP-Seq_HELA_Human	0.87320015
100	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.87266882

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	4.92456029
2	MP0003787_abnormal_imprinting	4.36708703
3	MP0003136_yellow_coat_color	3.58790866
4	MP0003123_paternal_imprinting	3.49781560
5	MP0002102_abnormal_ear_morphology	2.53844469
6	MP0008877_abnormal_DNA_methylation	2.35881029
7	MP0003646_muscle_fatigue	2.21676106
8	MP0003121_genomic_imprinting	2.18127676
9	MP0003195_calcinosis	2.04291578
10	MP0008058_abnormal_DNA_repair	1.99170486
11	MP0001485_abnormal_pinna_reflex	1.98688202
12	MP0001501_abnormal_sleep_pattern	1.97345166
13	MP0009046_muscle_twitch	1.96273122
14	MP0003011_delayed_dark_adaptation	1.93417695
15	MP0001984_abnormal_olfaction	1.90139642
16	MP0008789_abnormal_olfactory_epithelium	1.89232033
17	MP0005646_abnormal_pituitary_gland	1.82413376
18	MP0005671_abnormal_response_to	1.79572658
19	MP0006276_abnormal_autonomic_nervous	1.78546857
20	MP0003718_maternal_effect	1.74361605
21	MP0009384_cardiac_valve_regurgitation	1.73971439
22	MP0004885_abnormal_endolymph	1.69336232
23	MP0004133_heterotaxia	1.69329216
24	MP0002160_abnormal_reproductive_system	1.68842017
25	MP0010386_abnormal_urinary_bladder	1.68045546
26	MP0002234_abnormal_pharynx_morphology	1.67605596
27	MP0003693_abnormal_embryo_hatching	1.63818689
28	MP0010094_abnormal_chromosome_stability	1.59157461
29	MP0000631_abnormal_neuroendocrine_gland	1.58246313
30	MP0005253_abnormal_eye_physiology	1.53981624
31	MP0005645_abnormal_hypothalamus_physiol	1.53976162
32	MP0002938_white_spotting	1.53280482
33	MP0005187_abnormal_penis_morphology	1.52316589
34	MP0005075_abnormal_melanosome_morpholog	1.51081058
35	MP0005389_reproductive_system_phenotype	1.47643874
36	MP0004147_increased_porphyrin_level	1.46681950
37	MP0005551_abnormal_eye_electrophysiolog	1.45051938
38	MP0005171_absent_coat_pigmentation	1.44545376
39	MP0009745_abnormal_behavioral_response	1.43518362
40	MP0005423_abnormal_somatic_nervous	1.41685358
41	MP0006036_abnormal_mitochondrial_physio	1.38695805
42	MP0001486_abnormal_startle_reflex	1.36740494
43	MP0001764_abnormal_homeostasis	1.32552925
44	MP0002272_abnormal_nervous_system	1.32244645
45	MP0001919_abnormal_reproductive_system	1.31282863
46	MP0006072_abnormal_retinal_apoptosis	1.30932493
47	MP0002163_abnormal_gland_morphology	1.30215128
48	MP0008872_abnormal_physiological_respon	1.28032807
49	MP0008875_abnormal_xenobiotic_pharmacok	1.22586228
50	MP0006292_abnormal_olfactory_placode	1.20494301
51	MP0002736_abnormal_nociception_after	1.19848127
52	MP0002638_abnormal_pupillary_reflex	1.19297630
53	MP0001968_abnormal_touch/_nociception	1.17699591
54	MP0008995_early_reproductive_senescence	1.16988427
55	MP0004142_abnormal_muscle_tone	1.16770372
56	MP0008932_abnormal_embryonic_tissue	1.15374024
57	MP0003880_abnormal_central_pattern	1.13228209
58	MP0003119_abnormal_digestive_system	1.13065649
59	MP0005084_abnormal_gallbladder_morpholo	1.10085741
60	MP0000049_abnormal_middle_ear	1.09658280
61	MP0001986_abnormal_taste_sensitivity	1.06915578
62	MP0004043_abnormal_pH_regulation	1.06767508
63	MP0005499_abnormal_olfactory_system	1.06598504
64	MP0005394_taste/olfaction_phenotype	1.06598504
65	MP0001529_abnormal_vocalization	1.05153822
66	MP0004742_abnormal_vestibular_system	1.04443457
67	MP0002557_abnormal_social/conspecific_i	1.01718332
68	MP0002572_abnormal_emotion/affect_behav	1.00363985
69	MP0002837_dystrophic_cardiac_calcinosis	0.95031594
70	MP0000647_abnormal_sebaceous_gland	0.94444911
71	MP0009333_abnormal_splenocyte_physiolog	0.92317334
72	MP0006035_abnormal_mitochondrial_morpho	0.91232990
73	MP0001905_abnormal_dopamine_level	0.90556471
74	MP0005379_endocrine/exocrine_gland_phen	0.89591530
75	MP0000026_abnormal_inner_ear	0.86454165
76	MP0002090_abnormal_vision	0.84500893
77	MP0000516_abnormal_urinary_system	0.80015154
78	MP0005367_renal/urinary_system_phenotyp	0.80015154
79	MP0002733_abnormal_thermal_nociception	0.79708658
80	MP0005083_abnormal_biliary_tract	0.79419589
81	MP0002095_abnormal_skin_pigmentation	0.78948536
82	MP0009697_abnormal_copulation	0.78839382
83	MP0002064_seizures	0.75627342
84	MP0001119_abnormal_female_reproductive	0.75017668
85	MP0002752_abnormal_somatic_nervous	0.73047791
86	MP0008961_abnormal_basal_metabolism	0.72404042
87	MP0000653_abnormal_sex_gland	0.72260339
88	MP0003567_abnormal_fetal_cardiomyocyte	0.71606959
89	MP0001963_abnormal_hearing_physiology	0.68911989
90	MP0001929_abnormal_gametogenesis	0.66833515
91	MP0003937_abnormal_limbs/digits/tail_de	0.66763023
92	MP0000230_abnormal_systemic_arterial	0.66082882
93	MP0002127_abnormal_cardiovascular_syste	0.65462357
94	MP0003698_abnormal_male_reproductive	0.60931733
95	MP0002210_abnormal_sex_determination	0.60420039
96	MP0002693_abnormal_pancreas_physiology	0.60170866
97	MP0000639_abnormal_adrenal_gland	0.59972316
98	MP0001970_abnormal_pain_threshold	0.59171449
99	MP0006082_CNS_inflammation	0.58622409
100	MP0002295_abnormal_pulmonary_circulatio	0.58366458

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the pons (HP:0007361)	3.88928505
2	Hypoplasia of the pons (HP:0012110)	3.71100220
3	Increased hepatocellular lipid droplets (HP:0006565)	3.62469276
4	Type II lissencephaly (HP:0007260)	3.53256554
5	Congenital stationary night blindness (HP:0007642)	3.52205846
6	Lipid accumulation in hepatocytes (HP:0006561)	3.38258985
7	Absent/shortened dynein arms (HP:0200106)	3.35434683
8	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.35434683
9	Cerebellar dysplasia (HP:0007033)	3.34508557
10	Renal Fanconi syndrome (HP:0001994)	3.33717893
11	Mitochondrial inheritance (HP:0001427)	3.30911178
12	Pancreatic fibrosis (HP:0100732)	3.21062454
13	Acute necrotizing encephalopathy (HP:0006965)	3.17851301
14	True hermaphroditism (HP:0010459)	3.13415708
15	Increased CSF lactate (HP:0002490)	2.99460608
16	Pancreatic cysts (HP:0001737)	2.94776963
17	Hepatocellular necrosis (HP:0001404)	2.89932177
18	Abnormal mitochondria in muscle tissue (HP:0008316)	2.87203084
19	Increased intramyocellular lipid droplets (HP:0012240)	2.82565298
20	Medial flaring of the eyebrow (HP:0010747)	2.77878391
21	Exertional dyspnea (HP:0002875)	2.76414639
22	Acute encephalopathy (HP:0006846)	2.75392122
23	Progressive macrocephaly (HP:0004481)	2.70800272
24	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.70780572
25	Abnormality of alanine metabolism (HP:0010916)	2.70780572
26	Hyperalaninemia (HP:0003348)	2.70780572
27	Atonic seizures (HP:0010819)	2.67387595
28	Concave nail (HP:0001598)	2.63359198
29	Large for gestational age (HP:0001520)	2.62052040
30	Decreased central vision (HP:0007663)	2.62037550
31	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.50899923
32	Abolished electroretinogram (ERG) (HP:0000550)	2.50642253
33	Gaze-evoked nystagmus (HP:0000640)	2.49324054
34	Hepatic necrosis (HP:0002605)	2.48472096
35	Severe combined immunodeficiency (HP:0004430)	2.47505393
36	Respiratory difficulties (HP:0002880)	2.44614172
37	Ketoacidosis (HP:0001993)	2.40315308
38	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.35092268
39	Hypoplasia of the fovea (HP:0007750)	2.34974087
40	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.34974087
41	Brushfield spots (HP:0001088)	2.34134110
42	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.29639818
43	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.29639818
44	Ketosis (HP:0001946)	2.28039536
45	Short tibia (HP:0005736)	2.27424041
46	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.26593080
47	Lissencephaly (HP:0001339)	2.24742677
48	Increased muscle lipid content (HP:0009058)	2.24274455
49	T lymphocytopenia (HP:0005403)	2.19728658
50	Congenital, generalized hypertrichosis (HP:0004540)	2.19279444
51	Methylmalonic aciduria (HP:0012120)	2.19158529
52	Abnormality of the fovea (HP:0000493)	2.18712597
53	Asplenia (HP:0001746)	2.18512907
54	Supernumerary spleens (HP:0009799)	2.17845077
55	Congenital primary aphakia (HP:0007707)	2.17502928
56	Cerebral edema (HP:0002181)	2.17136756
57	Abnormal rod and cone electroretinograms (HP:0008323)	2.15848951
58	Thyroiditis (HP:0100646)	2.14089161
59	Abnormality of midbrain morphology (HP:0002418)	2.13639875
60	Molar tooth sign on MRI (HP:0002419)	2.13639875
61	Rib fusion (HP:0000902)	2.12027423
62	Hypothermia (HP:0002045)	2.10397568
63	Attenuation of retinal blood vessels (HP:0007843)	2.10333292
64	Gait imbalance (HP:0002141)	2.08086865
65	Nephronophthisis (HP:0000090)	2.07648353
66	Increased serum lactate (HP:0002151)	2.05783685
67	Hypoplasia of the thymus (HP:0000778)	2.05178936
68	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.04784703
69	Lactic acidosis (HP:0003128)	2.01794922
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.01683253
71	Abnormality of T cell number (HP:0011839)	2.00317109
72	Hypoproteinemia (HP:0003075)	1.95864006
73	Nephrogenic diabetes insipidus (HP:0009806)	1.94980824
74	Abnormality of the phalanges of the hallux (HP:0010057)	1.94460192
75	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94330627
76	Abnormal respiratory epithelium morphology (HP:0012253)	1.94330627
77	Genital tract atresia (HP:0001827)	1.90723575
78	Cellular immunodeficiency (HP:0005374)	1.90117751
79	Inability to walk (HP:0002540)	1.89646501
80	Methylmalonic acidemia (HP:0002912)	1.89503812
81	Pendular nystagmus (HP:0012043)	1.88421555
82	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.88323005
83	Optic disc pallor (HP:0000543)	1.86959845
84	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.86774488
85	Abnormality of the ileum (HP:0001549)	1.85449915
86	Meckel diverticulum (HP:0002245)	1.84383037
87	Absent thumb (HP:0009777)	1.83304273
88	Abnormal respiratory motile cilium physiology (HP:0012261)	1.83112511
89	Abnormality of renal resorption (HP:0011038)	1.82949884
90	Postaxial foot polydactyly (HP:0001830)	1.82805277
91	Bony spicule pigmentary retinopathy (HP:0007737)	1.82687904
92	Pancreatic islet-cell hyperplasia (HP:0004510)	1.82480028
93	Abnormal ciliary motility (HP:0012262)	1.81871132
94	Hypomagnesemia (HP:0002917)	1.81369581
95	Severe visual impairment (HP:0001141)	1.80517019
96	Vaginal atresia (HP:0000148)	1.79890750
97	Abnormal protein glycosylation (HP:0012346)	1.78222108
98	Abnormal glycosylation (HP:0012345)	1.78222108
99	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78222108
100	Abnormal protein N-linked glycosylation (HP:0012347)	1.78222108

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	5.72006273
2	TLK1	4.05105547
3	MAP4K2	3.32849847
4	FRK	2.85816116
5	TNIK	2.79911054
6	VRK1	2.73273102
7	VRK2	2.57780576
8	BCKDK	2.43223477
9	ERBB3	2.08468488
10	ADRBK2	2.08182590
11	KDR	1.96382893
12	WNK3	1.91458059
13	MAP3K4	1.88001913
14	MST4	1.87018909
15	MAP2K7	1.82827163
16	BCR	1.78360384
17	TAOK3	1.55892711
18	BMPR1B	1.50814219
19	PLK3	1.50143245
20	TNK2	1.47325497
21	EPHA3	1.43562361
22	EIF2AK1	1.43187501
23	TSSK6	1.42919814
24	RPS6KA4	1.39798462
25	GRK1	1.35936186
26	PNCK	1.30161041
27	CSNK1G3	1.29218026
28	EIF2AK3	1.27269027
29	CSNK1A1L	1.26512073
30	PAK3	1.26289363
31	SCYL2	1.24856949
32	CSNK1G1	1.20045956
33	BRSK2	1.19950377
34	AKT3	1.16088064
35	TXK	1.13068474
36	CSNK1G2	1.07767779
37	MKNK2	1.06836050
38	TRIM28	1.02439312
39	WEE1	0.97637921
40	ITK	0.97280468
41	MKNK1	0.94961548
42	PRKCE	0.89165649
43	TEC	0.86984871
44	BMPR2	0.86939336
45	OXSR1	0.82134733
46	TESK2	0.80396984
47	PLK2	0.80141028
48	AKT2	0.79286476
49	MYLK	0.76182463
50	RPS6KA5	0.76145774
51	MAP3K6	0.76054833
52	BRSK1	0.75557858
53	CDC7	0.73324761
54	CAMKK2	0.72909299
55	GRK7	0.71959719
56	PLK1	0.70366903
57	DYRK2	0.69463073
58	ADRBK1	0.69062798
59	PLK4	0.65710659
60	WNK4	0.63747823
61	BUB1	0.62854960
62	SRPK1	0.61005748
63	DYRK3	0.60705738
64	MINK1	0.60239462
65	IRAK1	0.59693733
66	MAP3K5	0.58384375
67	INSRR	0.58138363
68	LIMK1	0.56911514
69	TTK	0.54384353
70	MAP3K12	0.53187422
71	PRKCG	0.52722039
72	CAMK2A	0.50461686
73	ALK	0.50224379
74	CSNK1A1	0.47154939
75	DAPK1	0.45978579
76	PINK1	0.45793427
77	PIM2	0.45453271
78	AURKA	0.44838049
79	ATR	0.43564825
80	PRKCQ	0.41819526
81	CSNK1D	0.41609801
82	CSNK2A1	0.39342661
83	TIE1	0.39210344
84	NLK	0.38436624
85	NME1	0.38102427
86	STK38L	0.37111110
87	STK3	0.35972082
88	SIK3	0.35855314
89	EPHA4	0.33967820
90	NUAK1	0.33765164
91	FER	0.33026676
92	PDK2	0.32585605
93	AURKB	0.30855789
94	PRKACA	0.30545717
95	DAPK2	0.29320895
96	STK39	0.28851833
97	PIM1	0.27957145
98	ROCK1	0.26445016
99	PRKCA	0.25831864
100	KIT	0.25766720

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.24287246
2	Sulfur metabolism_Homo sapiens_hsa00920	3.74932702
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.44608328
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.25839360
5	Parkinsons disease_Homo sapiens_hsa05012	3.06763631
6	Protein export_Homo sapiens_hsa03060	2.81103140
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.46024351
8	Homologous recombination_Homo sapiens_hsa03440	2.36687128
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.33666911
10	RNA polymerase_Homo sapiens_hsa03020	2.21933553
11	Huntingtons disease_Homo sapiens_hsa05016	2.19410410
12	Phototransduction_Homo sapiens_hsa04744	2.11881648
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.10074226
14	Alzheimers disease_Homo sapiens_hsa05010	2.06893899
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.92182111
16	Butanoate metabolism_Homo sapiens_hsa00650	1.80167824
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.79316851
18	Mismatch repair_Homo sapiens_hsa03430	1.77623932
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.73192510
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.68115863
21	Basal transcription factors_Homo sapiens_hsa03022	1.64627474
22	Nicotine addiction_Homo sapiens_hsa05033	1.64069748
23	Sulfur relay system_Homo sapiens_hsa04122	1.63452175
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.57800444
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.45485529
26	Propanoate metabolism_Homo sapiens_hsa00640	1.42828278
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.41456075
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33343043
29	Caffeine metabolism_Homo sapiens_hsa00232	1.28567583
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.25060434
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.21841930
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.18864614
33	Type I diabetes mellitus_Homo sapiens_hsa04940	1.18620444
34	Spliceosome_Homo sapiens_hsa03040	1.18353563
35	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.14082305
36	Graft-versus-host disease_Homo sapiens_hsa05332	1.13986086
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.11490887
38	Purine metabolism_Homo sapiens_hsa00230	1.09623637
39	Taste transduction_Homo sapiens_hsa04742	1.05348459
40	RNA degradation_Homo sapiens_hsa03018	1.04974965
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04103787
42	Peroxisome_Homo sapiens_hsa04146	1.02186694
43	Allograft rejection_Homo sapiens_hsa05330	1.01699119
44	Ribosome_Homo sapiens_hsa03010	1.01362802
45	Antigen processing and presentation_Homo sapiens_hsa04612	0.95368399
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.86985194
47	Olfactory transduction_Homo sapiens_hsa04740	0.85172183
48	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.82558673
49	GABAergic synapse_Homo sapiens_hsa04727	0.79439542
50	Asthma_Homo sapiens_hsa05310	0.78822696
51	RNA transport_Homo sapiens_hsa03013	0.78608389
52	Morphine addiction_Homo sapiens_hsa05032	0.77920814
53	DNA replication_Homo sapiens_hsa03030	0.77148977
54	Steroid biosynthesis_Homo sapiens_hsa00100	0.76222361
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70804085
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70726201
57	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67263714
58	One carbon pool by folate_Homo sapiens_hsa00670	0.65930431
59	Base excision repair_Homo sapiens_hsa03410	0.62308726
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59825300
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59696127
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59040171
63	Serotonergic synapse_Homo sapiens_hsa04726	0.57618742
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.57538581
65	Metabolic pathways_Homo sapiens_hsa01100	0.55572726
66	Fatty acid elongation_Homo sapiens_hsa00062	0.55439935
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.55085458
68	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.52738011
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52254072
70	Salivary secretion_Homo sapiens_hsa04970	0.52040767
71	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51161699
72	Rheumatoid arthritis_Homo sapiens_hsa05323	0.50609666
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48045890
74	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.47894767
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.46786002
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45593897
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.44371207
78	Linoleic acid metabolism_Homo sapiens_hsa00591	0.41408941
79	Folate biosynthesis_Homo sapiens_hsa00790	0.38974126
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37863894
81	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.36255173
82	Mineral absorption_Homo sapiens_hsa04978	0.33821036
83	Regulation of autophagy_Homo sapiens_hsa04140	0.33561349
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.33208395
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.32963659
86	Viral myocarditis_Homo sapiens_hsa05416	0.32365691
87	Herpes simplex infection_Homo sapiens_hsa05168	0.32300880
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.30501103
89	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.30204376
90	Retinol metabolism_Homo sapiens_hsa00830	0.30172769
91	Tyrosine metabolism_Homo sapiens_hsa00350	0.30060922
92	Insulin secretion_Homo sapiens_hsa04911	0.29450001
93	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.29287096
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.29273145
95	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.28876494
96	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.28672303
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.28122151
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.26913768
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.26797312
100	Pyruvate metabolism_Homo sapiens_hsa00620	0.25174197

HNRNPA3P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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