ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	limb bud formation (GO:0060174)	7.07071954
2	glial cell proliferation (GO:0014009)	6.56081599
3	neural tube formation (GO:0001841)	5.82999765
4	presynaptic membrane assembly (GO:0097105)	5.58371291
5	sympathetic nervous system development (GO:0048485)	5.56583622
6	DNA damage response, detection of DNA damage (GO:0042769)	5.23128337
7	cardiac right ventricle morphogenesis (GO:0003215)	4.71164665
8	presynaptic membrane organization (GO:0097090)	4.65461493
9	transmission of nerve impulse (GO:0019226)	4.54103195
10	postsynaptic membrane organization (GO:0001941)	4.38359709
11	histone H3-K4 trimethylation (GO:0080182)	4.34451158
12	cardiac ventricle formation (GO:0003211)	4.23657110
13	regulation of male gonad development (GO:2000018)	4.23204121
14	kidney morphogenesis (GO:0060993)	4.14987467
15	central nervous system projection neuron axonogenesis (GO:0021952)	4.13763245
16	spinal cord development (GO:0021510)	4.02778403
17	central nervous system neuron axonogenesis (GO:0021955)	3.89619358
18	vocalization behavior (GO:0071625)	3.87308008
19	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.86244058
20	regulation of translation, ncRNA-mediated (GO:0045974)	3.86244058
21	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.86244058
22	cardiac chamber formation (GO:0003207)	3.83979729
23	fibroblast migration (GO:0010761)	3.75683511
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.68027822
25	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.64695056
26	DNA double-strand break processing (GO:0000729)	3.61833338
27	regulation of cilium movement (GO:0003352)	3.56579045
28	forebrain neuron differentiation (GO:0021879)	3.48997840
29	adaptation of signaling pathway (GO:0023058)	3.48807323
30	coenzyme catabolic process (GO:0009109)	3.46488121
31	somite development (GO:0061053)	3.42118511
32	neuroepithelial cell differentiation (GO:0060563)	3.41202639
33	dendritic spine morphogenesis (GO:0060997)	3.39394837
34	dopamine transport (GO:0015872)	3.36953898
35	positive regulation of developmental pigmentation (GO:0048087)	3.36200281
36	cornea development in camera-type eye (GO:0061303)	3.31267974
37	peptidyl-lysine trimethylation (GO:0018023)	3.29566420
38	axonal fasciculation (GO:0007413)	3.28107731
39	embryonic epithelial tube formation (GO:0001838)	3.25038090
40	positive regulation of male gonad development (GO:2000020)	3.20472531
41	ventricular septum morphogenesis (GO:0060412)	3.20353284
42	brain morphogenesis (GO:0048854)	3.18314984
43	synapse assembly (GO:0007416)	3.06683840
44	epithelial tube formation (GO:0072175)	3.05900148
45	regulation of hippo signaling (GO:0035330)	3.05162572
46	DNA demethylation (GO:0080111)	3.02557863
47	peristalsis (GO:0030432)	3.00462536
48	retinal cone cell development (GO:0046549)	2.98100389
49	positive regulation of synapse assembly (GO:0051965)	2.97514596
50	replication fork processing (GO:0031297)	2.96758158
51	head development (GO:0060322)	2.95346142
52	neuron recognition (GO:0008038)	2.94884283
53	atrial septum morphogenesis (GO:0060413)	2.91180188
54	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.85932254
55	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.85932254
56	adult feeding behavior (GO:0008343)	2.84686111
57	neuron cell-cell adhesion (GO:0007158)	2.84617306
58	regulation of neurotransmitter uptake (GO:0051580)	2.83478125
59	spinal cord motor neuron differentiation (GO:0021522)	2.81560049
60	retinal ganglion cell axon guidance (GO:0031290)	2.79761195
61	striatum development (GO:0021756)	2.79620102
62	neural crest cell development (GO:0014032)	2.78764275
63	negative regulation of dendrite development (GO:2000171)	2.77388011
64	regulation of microtubule-based movement (GO:0060632)	2.77231478
65	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.75451169
66	eyelid development in camera-type eye (GO:0061029)	2.75448377
67	catecholamine transport (GO:0051937)	2.74453837
68	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.71054844
69	substrate-independent telencephalic tangential migration (GO:0021826)	2.71054844
70	auditory receptor cell differentiation (GO:0042491)	2.70245893
71	cardiac ventricle morphogenesis (GO:0003208)	2.68161430
72	thalamus development (GO:0021794)	2.67747118
73	stem cell development (GO:0048864)	2.64480959
74	photoreceptor cell development (GO:0042461)	2.63615118
75	regulation of collateral sprouting (GO:0048670)	2.63369113
76	negative regulation of DNA binding (GO:0043392)	2.59706111
77	epithelial cilium movement (GO:0003351)	2.59027332
78	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.58521372
79	sequestering of actin monomers (GO:0042989)	2.58306528
80	hindbrain development (GO:0030902)	2.56201457
81	dentate gyrus development (GO:0021542)	2.55148186
82	cilium morphogenesis (GO:0060271)	2.55042998
83	nonmotile primary cilium assembly (GO:0035058)	2.54969556
84	behavioral response to cocaine (GO:0048148)	2.54447159
85	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	2.54231249
86	mechanoreceptor differentiation (GO:0042490)	2.53364417
87	peptidyl-lysine methylation (GO:0018022)	2.53352874
88	keratinocyte development (GO:0003334)	2.52655520
89	kinetochore assembly (GO:0051382)	2.52306286
90	polyol transport (GO:0015791)	2.51413665
91	mesenchymal cell development (GO:0014031)	2.51234674
92	eye photoreceptor cell development (GO:0042462)	2.50368161
93	protein-cofactor linkage (GO:0018065)	2.48742471
94	regulation of timing of cell differentiation (GO:0048505)	2.46843243
95	lymphoid progenitor cell differentiation (GO:0002320)	2.46504643
96	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.45451845
97	glyoxylate metabolic process (GO:0046487)	2.44989767
98	fat-soluble vitamin catabolic process (GO:0042363)	2.44703629
99	vitamin catabolic process (GO:0009111)	2.44703629
100	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.43199490

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.84635852
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.97812056
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.97229467
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.92901649
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.87757481
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.83910619
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.67253697
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.64850865
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.60356276
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.56880425
11	VDR_22108803_ChIP-Seq_LS180_Human	2.48054460
12	P300_19829295_ChIP-Seq_ESCs_Human	2.31129611
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.31009229
14	FUS_26573619_Chip-Seq_HEK293_Human	2.26643270
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.13121081
16	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.06431623
17	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.05213042
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.01012607
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.96180933
20	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.94602574
21	EWS_26573619_Chip-Seq_HEK293_Human	1.91307962
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87194583
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.84044460
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.83537171
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.81762244
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.74033477
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.72143479
28	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.70078112
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69395530
30	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.67862800
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.67165305
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.65476535
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.62028904
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61894820
35	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.61215044
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.57623943
37	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.56298347
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.55424875
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.54543323
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54543323
41	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.52897675
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.52401735
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51955990
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.51955990
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.51901524
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49609025
47	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.47088929
48	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46726473
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45060121
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44222032
51	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.41050172
52	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40173428
53	STAT3_23295773_ChIP-Seq_U87_Human	1.39563940
54	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.35976562
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.33959667
56	TCF4_23295773_ChIP-Seq_U87_Human	1.32611704
57	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.30141203
58	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.30099580
59	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.29149813
60	AR_25329375_ChIP-Seq_VCAP_Human	1.29073871
61	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.27863868
62	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.26566462
63	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.25620157
64	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25082509
65	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.21028793
66	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.17989931
67	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.16377878
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15154854
69	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13647483
70	SOX9_26525672_Chip-Seq_HEART_Mouse	1.12570086
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12056877
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12056877
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11897574
74	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.11755224
75	REST_21632747_ChIP-Seq_MESCs_Mouse	1.10874197
76	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.10871220
77	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09007409
78	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05382334
79	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.04508593
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04270418
81	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.03838226
82	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03671382
83	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.03402948
84	MYC_18940864_ChIP-ChIP_HL60_Human	1.03134534
85	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.01337847
86	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.00783387
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00345861
88	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00010419
89	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.98914909
90	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.98708953
91	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98008600
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97862540
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97841761
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97570425
95	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97447607
96	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96639106
97	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.93077534
98	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.92867938
99	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.92774914
100	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.92687373

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002751_abnormal_autonomic_nervous	3.16837946
2	MP0003880_abnormal_central_pattern	3.13368818
3	MP0000778_abnormal_nervous_system	2.94665712
4	MP0001529_abnormal_vocalization	2.79828497
5	MP0000516_abnormal_urinary_system	2.77896030
6	MP0005367_renal/urinary_system_phenotyp	2.77896030
7	MP0000566_synostosis	2.56600551
8	MP0002736_abnormal_nociception_after	2.17804927
9	MP0006276_abnormal_autonomic_nervous	2.10951661
10	MP0002938_white_spotting	2.09969310
11	MP0002102_abnormal_ear_morphology	1.92889213
12	MP0002163_abnormal_gland_morphology	1.91919183
13	MP0000537_abnormal_urethra_morphology	1.88426943
14	MP0006292_abnormal_olfactory_placode	1.84735069
15	MP0000631_abnormal_neuroendocrine_gland	1.81032260
16	MP0010030_abnormal_orbit_morphology	1.80873383
17	MP0002234_abnormal_pharynx_morphology	1.79074141
18	MP0000372_irregular_coat_pigmentation	1.76700888
19	MP0005551_abnormal_eye_electrophysiolog	1.73135461
20	MP0005253_abnormal_eye_physiology	1.72230252
21	MP0003938_abnormal_ear_development	1.67727151
22	MP0004885_abnormal_endolymph	1.66770846
23	MP0005503_abnormal_tendon_morphology	1.66584020
24	MP0001485_abnormal_pinna_reflex	1.65016312
25	MP0008872_abnormal_physiological_respon	1.64754088
26	MP0000569_abnormal_digit_pigmentation	1.61093840
27	MP0004742_abnormal_vestibular_system	1.56943425
28	MP0005379_endocrine/exocrine_gland_phen	1.56771626
29	MP0008789_abnormal_olfactory_epithelium	1.56642508
30	MP0006072_abnormal_retinal_apoptosis	1.54105005
31	MP0001984_abnormal_olfaction	1.53176317
32	MP0000049_abnormal_middle_ear	1.52818388
33	MP0003718_maternal_effect	1.50222847
34	MP0001968_abnormal_touch/_nociception	1.49259483
35	MP0001177_atelectasis	1.45560194
36	MP0000647_abnormal_sebaceous_gland	1.45543075
37	MP0003937_abnormal_limbs/digits/tail_de	1.44450638
38	MP0002282_abnormal_trachea_morphology	1.44166093
39	MP0000427_abnormal_hair_cycle	1.42642537
40	MP0002095_abnormal_skin_pigmentation	1.40022788
41	MP0003755_abnormal_palate_morphology	1.39559591
42	MP0008058_abnormal_DNA_repair	1.36749744
43	MP0008877_abnormal_DNA_methylation	1.36254673
44	MP0005075_abnormal_melanosome_morpholog	1.34085766
45	MP0001486_abnormal_startle_reflex	1.31889953
46	MP0009046_muscle_twitch	1.31831771
47	MP0005645_abnormal_hypothalamus_physiol	1.27774829
48	MP0002735_abnormal_chemical_nociception	1.26748723
49	MP0002184_abnormal_innervation	1.25223887
50	MP0005248_abnormal_Harderian_gland	1.24727592
51	MP0004142_abnormal_muscle_tone	1.21806160
52	MP0003861_abnormal_nervous_system	1.20524401
53	MP0000026_abnormal_inner_ear	1.18123617
54	MP0003385_abnormal_body_wall	1.16431606
55	MP0005386_behavior/neurological_phenoty	1.14599629
56	MP0004924_abnormal_behavior	1.14599629
57	MP0009745_abnormal_behavioral_response	1.13704001
58	MP0002272_abnormal_nervous_system	1.13241906
59	MP0002734_abnormal_mechanical_nocicepti	1.12416611
60	MP0002233_abnormal_nose_morphology	1.12151101
61	MP0005187_abnormal_penis_morphology	1.11471525
62	MP0005646_abnormal_pituitary_gland	1.09247368
63	MP0001299_abnormal_eye_distance/	1.08288377
64	MP0002557_abnormal_social/conspecific_i	1.08051439
65	MP0003121_genomic_imprinting	1.07967003
66	MP0002638_abnormal_pupillary_reflex	1.06822768
67	MP0004043_abnormal_pH_regulation	1.06675552
68	MP0003122_maternal_imprinting	1.05534515
69	MP0005394_taste/olfaction_phenotype	1.05095849
70	MP0005499_abnormal_olfactory_system	1.05095849
71	MP0005391_vision/eye_phenotype	1.04296037
72	MP0003119_abnormal_digestive_system	1.02796788
73	MP0005423_abnormal_somatic_nervous	1.02439312
74	MP0003935_abnormal_craniofacial_develop	1.00154138
75	MP0004147_increased_porphyrin_level	0.99989419
76	MP0002752_abnormal_somatic_nervous	0.99490970
77	MP0000538_abnormal_urinary_bladder	0.98460711
78	MP0000015_abnormal_ear_pigmentation	0.97974034
79	MP0009780_abnormal_chondrocyte_physiolo	0.96230458
80	MP0001286_abnormal_eye_development	0.95007121
81	MP0003315_abnormal_perineum_morphology	0.93118109
82	MP0003567_abnormal_fetal_cardiomyocyte	0.91421682
83	MP0002295_abnormal_pulmonary_circulatio	0.89357456
84	MP0000534_abnormal_ureter_morphology	0.88786228
85	MP0002152_abnormal_brain_morphology	0.88541500
86	MP0002064_seizures	0.86635701
87	MP0004085_abnormal_heartbeat	0.86348220
88	MP0002067_abnormal_sensory_capabilities	0.86298971
89	MP0009697_abnormal_copulation	0.86260476
90	MP0003950_abnormal_plasma_membrane	0.86133490
91	MP0004270_analgesia	0.85507165
92	MP0004133_heterotaxia	0.85046643
93	MP0005084_abnormal_gallbladder_morpholo	0.84983143
94	MP0002928_abnormal_bile_duct	0.84770046
95	MP0002837_dystrophic_cardiac_calcinosis	0.84319583
96	MP0003635_abnormal_synaptic_transmissio	0.82508319
97	MP0001346_abnormal_lacrimal_gland	0.82253145
98	MP0002882_abnormal_neuron_morphology	0.78873877
99	MP0003942_abnormal_urinary_system	0.78763654
100	MP0005195_abnormal_posterior_eye	0.78280533

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	4.88141929
2	Hyperventilation (HP:0002883)	3.93959287
3	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.64715620
4	Drooling (HP:0002307)	3.47740498
5	Thyroid-stimulating hormone excess (HP:0002925)	3.42881377
6	True hermaphroditism (HP:0010459)	3.36892577
7	Delayed CNS myelination (HP:0002188)	3.32966915
8	Megalencephaly (HP:0001355)	3.29505633
9	Pancreatic cysts (HP:0001737)	3.26897715
10	Excessive salivation (HP:0003781)	3.18151284
11	Pancreatic fibrosis (HP:0100732)	3.07165303
12	Hypoplastic ischia (HP:0003175)	3.01873133
13	Facial hemangioma (HP:0000329)	2.94414835
14	Absent speech (HP:0001344)	2.83822007
15	Hepatoblastoma (HP:0002884)	2.82626495
16	Abnormality of the ischium (HP:0003174)	2.75530797
17	Abnormality of the antihelix (HP:0009738)	2.60085912
18	Cupped ear (HP:0000378)	2.58547385
19	Broad alveolar ridges (HP:0000187)	2.53180510
20	Intellectual disability, progressive (HP:0006887)	2.52957236
21	Hypoplastic labia majora (HP:0000059)	2.48854746
22	Neoplasm of the oral cavity (HP:0100649)	2.43488213
23	Tubulointerstitial nephritis (HP:0001970)	2.42981377
24	Intestinal atresia (HP:0011100)	2.40130159
25	Patellar aplasia (HP:0006443)	2.38920609
26	3-Methylglutaconic aciduria (HP:0003535)	2.35649930
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.30515600
28	Absent/shortened dynein arms (HP:0200106)	2.30515600
29	Septo-optic dysplasia (HP:0100842)	2.29919416
30	Narrow forehead (HP:0000341)	2.29741034
31	Abnormality of the metopic suture (HP:0005556)	2.29649738
32	Aplasia/Hypoplasia of the patella (HP:0006498)	2.28995081
33	Focal motor seizures (HP:0011153)	2.28979273
34	Abnormality of the labia majora (HP:0012881)	2.27017449
35	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.25929721
36	Neonatal respiratory distress (HP:0002643)	2.25610692
37	Pendular nystagmus (HP:0012043)	2.25504117
38	Abnormality of the astrocytes (HP:0100707)	2.19674660
39	Astrocytoma (HP:0009592)	2.19674660
40	Chorioretinal atrophy (HP:0000533)	2.19145476
41	High anterior hairline (HP:0009890)	2.18427626
42	Preaxial hand polydactyly (HP:0001177)	2.15788853
43	Broad-based gait (HP:0002136)	2.11753558
44	Ependymoma (HP:0002888)	2.09415299
45	Fair hair (HP:0002286)	2.08336714
46	Oligodactyly (hands) (HP:0001180)	2.08090150
47	Postaxial hand polydactyly (HP:0001162)	2.07613345
48	Molar tooth sign on MRI (HP:0002419)	2.05386398
49	Abnormality of midbrain morphology (HP:0002418)	2.05386398
50	Tented upper lip vermilion (HP:0010804)	2.05244459
51	Delayed myelination (HP:0012448)	2.05212357
52	Cystic liver disease (HP:0006706)	2.02919081
53	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.02728283
54	Abnormality of the pubic bones (HP:0003172)	2.01864071
55	Increased corneal curvature (HP:0100692)	2.01697452
56	Keratoconus (HP:0000563)	2.01697452
57	Overlapping toe (HP:0001845)	2.01653091
58	Abnormality of macular pigmentation (HP:0008002)	2.01621353
59	Medial flaring of the eyebrow (HP:0010747)	2.01411307
60	Sclerocornea (HP:0000647)	1.99740764
61	Bony spicule pigmentary retinopathy (HP:0007737)	1.99064296
62	Abnormal ciliary motility (HP:0012262)	1.97375640
63	Colon cancer (HP:0003003)	1.96894395
64	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.96674738
65	Short 1st metacarpal (HP:0010034)	1.96674738
66	Abnormality of the labia (HP:0000058)	1.95688899
67	Hemiparesis (HP:0001269)	1.95322595
68	Abnormal rod and cone electroretinograms (HP:0008323)	1.94613267
69	Nephronophthisis (HP:0000090)	1.92077861
70	Inability to walk (HP:0002540)	1.91900104
71	Anencephaly (HP:0002323)	1.91694008
72	Attenuation of retinal blood vessels (HP:0007843)	1.90339069
73	Dandy-Walker malformation (HP:0001305)	1.88313307
74	Abnormal respiratory epithelium morphology (HP:0012253)	1.86918558
75	Abnormal respiratory motile cilium morphology (HP:0005938)	1.86918558
76	Focal seizures (HP:0007359)	1.86593614
77	Abnormality of the renal medulla (HP:0100957)	1.83658869
78	Optic nerve hypoplasia (HP:0000609)	1.82659716
79	Labial hypoplasia (HP:0000066)	1.82560044
80	Hyperglycinemia (HP:0002154)	1.82173921
81	Long clavicles (HP:0000890)	1.80557943
82	Widely spaced teeth (HP:0000687)	1.79228040
83	Abolished electroretinogram (ERG) (HP:0000550)	1.78699672
84	Congenital stationary night blindness (HP:0007642)	1.76974011
85	Single transverse palmar crease (HP:0000954)	1.76512343
86	Scrotal hypoplasia (HP:0000046)	1.76070603
87	Decreased lacrimation (HP:0000633)	1.74992061
88	Lissencephaly (HP:0001339)	1.73421430
89	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.73158181
90	Heterotopia (HP:0002282)	1.72268268
91	Abnormality of salivation (HP:0100755)	1.72047517
92	Abnormality of the 1st metacarpal (HP:0010009)	1.70381934
93	Generalized aminoaciduria (HP:0002909)	1.68661705
94	Renal hypoplasia (HP:0000089)	1.68531895
95	Congenital primary aphakia (HP:0007707)	1.68411128
96	Gait imbalance (HP:0002141)	1.66724624
97	Laryngomalacia (HP:0001601)	1.66368025
98	Abnormality of lateral ventricle (HP:0030047)	1.66103849
99	Chorioretinal coloboma (HP:0000567)	1.65329788
100	Absent septum pellucidum (HP:0001331)	1.63924267

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.84376789
2	WNK3	3.82454965
3	TRIM28	3.75427032
4	EPHB2	3.65189658
5	FRK	3.57616302
6	MAP4K2	3.09605444
7	CASK	2.85917060
8	EPHA4	2.59515839
9	AKT3	2.58154785
10	MAP3K4	2.46304189
11	PLK2	1.99441031
12	EIF2AK3	1.94597596
13	PAK3	1.91405803
14	PNCK	1.88590787
15	EIF2AK1	1.82881374
16	BMPR1B	1.66326256
17	FGFR2	1.59258926
18	KSR1	1.56116425
19	TLK1	1.52283920
20	NUAK1	1.51753172
21	ILK	1.50149853
22	BRD4	1.46906511
23	INSRR	1.40380164
24	TNIK	1.40001646
25	PLK3	1.27558837
26	MAPK13	1.25534877
27	CSNK1G2	1.22411669
28	TGFBR1	1.20438007
29	MKNK2	1.15306639
30	VRK1	1.11810982
31	NTRK2	1.08054461
32	DYRK2	1.07427096
33	STK38L	1.05093543
34	SRPK1	1.04670255
35	ACVR1B	1.01742730
36	ADRBK2	0.97846369
37	ERBB3	0.97753001
38	PRKCE	0.96717653
39	BCR	0.92901502
40	MAP2K7	0.88125594
41	CAMK1G	0.87412311
42	GRK1	0.87244924
43	STK24	0.86633659
44	MKNK1	0.84449821
45	TAF1	0.84074998
46	OXSR1	0.82679995
47	CSNK1G1	0.80072560
48	CSNK1A1L	0.79444187
49	VRK2	0.78752038
50	CSNK1G3	0.78730032
51	STK3	0.77280716
52	ERBB2	0.76473419
53	MAP2K4	0.73216935
54	CSNK1D	0.69414941
55	STK39	0.69147459
56	EPHA3	0.67009436
57	SGK2	0.65524415
58	DYRK1A	0.63496459
59	FGFR1	0.62963835
60	PRKCZ	0.61680171
61	PAK6	0.59978435
62	PBK	0.55468596
63	NLK	0.54586200
64	CDK3	0.54447154
65	NTRK3	0.50961777
66	DYRK3	0.50525514
67	PRKCG	0.50491753
68	PLK1	0.50221576
69	ADRBK1	0.49542153
70	PRKG1	0.48521120
71	MST4	0.47110605
72	CAMK1	0.46938017
73	CDK8	0.46406181
74	PLK4	0.45762813
75	CDC7	0.45700859
76	YES1	0.44765348
77	ATM	0.43675575
78	ROCK1	0.41575230
79	CDK9	0.36848118
80	CHEK1	0.34610126
81	PRKDC	0.31551033
82	CHUK	0.31230479
83	PAK2	0.31208253
84	SGK223	0.31199090
85	SGK494	0.31199090
86	MATK	0.30602775
87	RPS6KA5	0.30482856
88	MAPK8	0.28589510
89	PRKACA	0.28578097
90	PINK1	0.28040242
91	WEE1	0.27450703
92	FGR	0.24481504
93	PRKCB	0.24073325
94	MAP3K12	0.23701149
95	CDK1	0.23230772
96	SGK3	0.22937537
97	PASK	0.22256972
98	IGF1R	0.21808176
99	BCKDK	0.21777260
100	GSK3B	0.21644746

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	3.26749321
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.03100291
3	Sulfur metabolism_Homo sapiens_hsa00920	2.68742991
4	Selenocompound metabolism_Homo sapiens_hsa00450	2.62254383
5	Steroid biosynthesis_Homo sapiens_hsa00100	2.59772045
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.38447870
7	Butanoate metabolism_Homo sapiens_hsa00650	2.21893682
8	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.14930167
9	Protein export_Homo sapiens_hsa03060	2.14412618
10	Basal cell carcinoma_Homo sapiens_hsa05217	1.97688854
11	Homologous recombination_Homo sapiens_hsa03440	1.94082179
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.92628550
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.90458007
14	Propanoate metabolism_Homo sapiens_hsa00640	1.89556987
15	Nicotine addiction_Homo sapiens_hsa05033	1.86704902
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.85668496
17	RNA polymerase_Homo sapiens_hsa03020	1.68702368
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.64874013
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.57297169
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.52312719
21	Parkinsons disease_Homo sapiens_hsa05012	1.49325092
22	Cocaine addiction_Homo sapiens_hsa05030	1.43381767
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.41864225
24	ABC transporters_Homo sapiens_hsa02010	1.37574858
25	Phototransduction_Homo sapiens_hsa04744	1.29734240
26	Proteasome_Homo sapiens_hsa03050	1.28343712
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.21155548
28	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.16885584
29	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.15364863
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.14804812
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.12986930
32	Morphine addiction_Homo sapiens_hsa05032	1.10355451
33	RNA transport_Homo sapiens_hsa03013	1.09641325
34	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.08999135
35	Wnt signaling pathway_Homo sapiens_hsa04310	1.08681852
36	Huntingtons disease_Homo sapiens_hsa05016	1.05661045
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.04983574
38	Glutamatergic synapse_Homo sapiens_hsa04724	1.03980448
39	GABAergic synapse_Homo sapiens_hsa04727	1.03913231
40	Insulin secretion_Homo sapiens_hsa04911	1.02091932
41	Amphetamine addiction_Homo sapiens_hsa05031	1.00664061
42	cAMP signaling pathway_Homo sapiens_hsa04024	0.99146367
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97294432
44	Lysine degradation_Homo sapiens_hsa00310	0.96352907
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.95950108
46	Taste transduction_Homo sapiens_hsa04742	0.95443938
47	Circadian entrainment_Homo sapiens_hsa04713	0.94920801
48	Peroxisome_Homo sapiens_hsa04146	0.94601524
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.91943371
50	Serotonergic synapse_Homo sapiens_hsa04726	0.90109464
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.88346311
52	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.87488177
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.87284029
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.87274160
55	Hippo signaling pathway_Homo sapiens_hsa04390	0.86802518
56	Long-term depression_Homo sapiens_hsa04730	0.86086453
57	Cholinergic synapse_Homo sapiens_hsa04725	0.84301105
58	Purine metabolism_Homo sapiens_hsa00230	0.83753584
59	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.83232475
60	RNA degradation_Homo sapiens_hsa03018	0.82339204
61	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.80620691
62	Retinol metabolism_Homo sapiens_hsa00830	0.79927676
63	Cell cycle_Homo sapiens_hsa04110	0.75967634
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74887368
65	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.72756495
66	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.71613585
67	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.71456969
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71199364
69	Alzheimers disease_Homo sapiens_hsa05010	0.69740891
70	Olfactory transduction_Homo sapiens_hsa04740	0.67911454
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67459175
72	Tryptophan metabolism_Homo sapiens_hsa00380	0.66471944
73	Melanoma_Homo sapiens_hsa05218	0.66183187
74	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.66182703
75	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.63557512
76	Melanogenesis_Homo sapiens_hsa04916	0.63441007
77	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.61345165
78	Cardiac muscle contraction_Homo sapiens_hsa04260	0.59762774
79	Fatty acid degradation_Homo sapiens_hsa00071	0.59105032
80	p53 signaling pathway_Homo sapiens_hsa04115	0.57758966
81	Prostate cancer_Homo sapiens_hsa05215	0.56343195
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54138989
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52400462
84	Caffeine metabolism_Homo sapiens_hsa00232	0.51648298
85	Ribosome_Homo sapiens_hsa03010	0.51376059
86	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.50252241
87	Axon guidance_Homo sapiens_hsa04360	0.49929512
88	Renin secretion_Homo sapiens_hsa04924	0.49370117
89	Adherens junction_Homo sapiens_hsa04520	0.49313797
90	Chemical carcinogenesis_Homo sapiens_hsa05204	0.48086717
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47888625
92	Colorectal cancer_Homo sapiens_hsa05210	0.47833350
93	Circadian rhythm_Homo sapiens_hsa04710	0.46981709
94	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.44722633
95	Spliceosome_Homo sapiens_hsa03040	0.43822681
96	DNA replication_Homo sapiens_hsa03030	0.43629697
97	Regulation of autophagy_Homo sapiens_hsa04140	0.42405931
98	FoxO signaling pathway_Homo sapiens_hsa04068	0.39268932
99	Mismatch repair_Homo sapiens_hsa03430	0.38270635
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37119978

HNRNPA3P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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