HNRNPA3P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)6.19489339
2ribosomal small subunit biogenesis (GO:0042274)6.14456591
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.13613186
4ATP synthesis coupled proton transport (GO:0015986)5.88487715
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.88487715
6maturation of SSU-rRNA (GO:0030490)5.57533291
7peptidyl-histidine modification (GO:0018202)5.47218993
8viral transcription (GO:0019083)5.18298089
9translational termination (GO:0006415)5.07865993
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.74428020
11proteasome assembly (GO:0043248)4.66865062
12regulation of translational termination (GO:0006449)4.57414447
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.53335145
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.50960668
15protein targeting to ER (GO:0045047)4.47179261
16cotranslational protein targeting to membrane (GO:0006613)4.44279837
17translational elongation (GO:0006414)4.44159558
18respiratory electron transport chain (GO:0022904)4.42449668
19mitochondrial respiratory chain complex I assembly (GO:0032981)4.35224898
20NADH dehydrogenase complex assembly (GO:0010257)4.35224898
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.35224898
22chromatin remodeling at centromere (GO:0031055)4.31771549
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.30969399
24electron transport chain (GO:0022900)4.29940544
25regulation of activation of Janus kinase activity (GO:0010533)4.26295846
26pseudouridine synthesis (GO:0001522)4.16603226
27negative regulation of phagocytosis (GO:0050765)4.15579054
28protein localization to endoplasmic reticulum (GO:0070972)4.14665144
29ribosomal large subunit biogenesis (GO:0042273)4.14313475
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.11789210
31CENP-A containing nucleosome assembly (GO:0034080)4.07989816
32ribonucleoprotein complex biogenesis (GO:0022613)4.07701477
33exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.06518656
34translational initiation (GO:0006413)4.05859619
35translation (GO:0006412)4.02727124
36maturation of 5.8S rRNA (GO:0000460)4.00752987
37ribosomal small subunit assembly (GO:0000028)4.00564638
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.97751663
39mitochondrial respiratory chain complex assembly (GO:0033108)3.90883190
40cellular protein complex disassembly (GO:0043624)3.87033048
41protein complex biogenesis (GO:0070271)3.84221184
42formation of translation preinitiation complex (GO:0001731)3.82912568
43spliceosomal snRNP assembly (GO:0000387)3.81379608
44viral life cycle (GO:0019058)3.80848446
45cellular component biogenesis (GO:0044085)3.78782523
46rRNA processing (GO:0006364)3.77365711
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.76230336
48termination of RNA polymerase III transcription (GO:0006386)3.76230336
49rRNA modification (GO:0000154)3.75930410
50regulation of mitochondrial translation (GO:0070129)3.73506457
51negative regulation of mast cell activation (GO:0033004)3.71134731
52rRNA metabolic process (GO:0016072)3.62491691
53regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.61851124
54regulation of mitotic spindle checkpoint (GO:1903504)3.61851124
55DNA strand elongation involved in DNA replication (GO:0006271)3.56566340
56water-soluble vitamin biosynthetic process (GO:0042364)3.46956014
57protein targeting to mitochondrion (GO:0006626)3.43003201
58ribosome biogenesis (GO:0042254)3.40276725
59DNA deamination (GO:0045006)3.39609176
60DNA strand elongation (GO:0022616)3.39149188
61establishment of integrated proviral latency (GO:0075713)3.37129929
62histone exchange (GO:0043486)3.34927283
63protein complex disassembly (GO:0043241)3.30102606
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29641333
65purine nucleobase biosynthetic process (GO:0009113)3.28826988
66DNA replication-independent nucleosome organization (GO:0034724)3.25579546
67DNA replication-independent nucleosome assembly (GO:0006336)3.25579546
68nuclear-transcribed mRNA catabolic process (GO:0000956)3.24491185
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21672041
70negative regulation of ligase activity (GO:0051352)3.21672041
71establishment of protein localization to mitochondrion (GO:0072655)3.21408933
72telomere maintenance via semi-conservative replication (GO:0032201)3.19408045
73DNA replication initiation (GO:0006270)3.18518639
74histone mRNA metabolic process (GO:0008334)3.18009805
75nucleobase biosynthetic process (GO:0046112)3.17282821
76deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.17126326
77macromolecular complex disassembly (GO:0032984)3.14318743
78ATP biosynthetic process (GO:0006754)3.12433784
79purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.11859050
80DNA replication checkpoint (GO:0000076)3.11633487
81pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.10784094
82GTP biosynthetic process (GO:0006183)3.10039059
83purine nucleoside triphosphate biosynthetic process (GO:0009145)3.07294548
84mRNA catabolic process (GO:0006402)3.05804974
85heterochromatin organization (GO:0070828)3.04608740
86regulation of transcription from RNA polymerase I promoter (GO:0006356)3.03325320
87protein neddylation (GO:0045116)2.98457707
88protein localization to mitochondrion (GO:0070585)2.97901916
89ribosome assembly (GO:0042255)2.94721666
90folic acid-containing compound biosynthetic process (GO:0009396)2.94471961
91UTP biosynthetic process (GO:0006228)2.92751384
92RNA catabolic process (GO:0006401)2.92050557
93ribonucleoside triphosphate biosynthetic process (GO:0009201)2.89050096
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87520410
95protein targeting to membrane (GO:0006612)2.87486273
96mRNA splicing, via spliceosome (GO:0000398)2.87014396
97RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.87014396
98regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.86719767
99RNA splicing, via transesterification reactions (GO:0000375)2.86248696
100pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.84311386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.89994408
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.46586208
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.44293480
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.68909399
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.66953822
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66765977
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.45479541
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.29929637
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23971659
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.14119444
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.08892932
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02936698
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01796543
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.97392503
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83658116
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82710951
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.74836771
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69652939
19XRN2_22483619_ChIP-Seq_HELA_Human2.40711055
20FOXP3_21729870_ChIP-Seq_TREG_Human2.37855364
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36931483
22ELK1_19687146_ChIP-ChIP_HELA_Human2.32141443
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30954386
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29350079
25TTF2_22483619_ChIP-Seq_HELA_Human2.27068903
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22232323
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.18453437
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17985852
29DCP1A_22483619_ChIP-Seq_HELA_Human2.17707829
30VDR_23849224_ChIP-Seq_CD4+_Human2.12581853
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11727335
32NOTCH1_21737748_ChIP-Seq_TLL_Human2.10055124
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.07696927
34SRY_22984422_ChIP-ChIP_TESTIS_Rat2.04316325
35ESR1_15608294_ChIP-ChIP_MCF-7_Human2.01478195
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.99935815
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96758768
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93714957
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89784062
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83978397
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83296843
42GABP_19822575_ChIP-Seq_HepG2_Human1.81817715
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76997242
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71460833
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70125272
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.64206256
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.58057004
48MYC_18940864_ChIP-ChIP_HL60_Human1.46527697
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44480177
50ZNF263_19887448_ChIP-Seq_K562_Human1.41807450
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40216467
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38970977
53MYC_22102868_ChIP-Seq_BL_Human1.36071844
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35031584
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33254729
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30755729
57CIITA_25753668_ChIP-Seq_RAJI_Human1.26595263
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23412308
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21182936
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17712042
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.15715514
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14542813
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13526422
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12217549
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11429458
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10340910
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08994973
68SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06047897
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03086021
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01978695
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01641395
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00085262
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99420498
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97018096
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94333148
76AR_21909140_ChIP-Seq_LNCAP_Human0.94268658
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93895094
78SOX2_16153702_ChIP-ChIP_HESCs_Human0.92985700
79KDM5A_27292631_Chip-Seq_BREAST_Human0.90926740
80ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90802909
81FOXP1_21924763_ChIP-Seq_HESCs_Human0.86524695
82NANOG_16153702_ChIP-ChIP_HESCs_Human0.85720685
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84183645
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82748312
85SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82143281
86CTCF_18555785_ChIP-Seq_MESCs_Mouse0.82019743
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80242441
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80192363
89TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78816710
90EZH2_22144423_ChIP-Seq_EOC_Human0.77735632
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76375683
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76284990
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73970086
94CTCF_20526341_ChIP-Seq_ESCs_Human0.73873134
95KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.70506333
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.69413060
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.68903472
98P68_20966046_ChIP-Seq_HELA_Human0.68696416
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.68460862
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.67667870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.08545877
2MP0009379_abnormal_foot_pigmentation3.67624712
3MP0003111_abnormal_nucleus_morphology3.51194199
4MP0010094_abnormal_chromosome_stability3.37554264
5MP0004957_abnormal_blastocyst_morpholog3.29487989
6MP0003786_premature_aging3.25088987
7MP0006292_abnormal_olfactory_placode3.16345852
8MP0003077_abnormal_cell_cycle2.83678870
9MP0002163_abnormal_gland_morphology2.80708298
10MP0010307_abnormal_tumor_latency2.42871197
11MP0003123_paternal_imprinting2.41355841
12MP0008058_abnormal_DNA_repair2.23629169
13MP0008932_abnormal_embryonic_tissue2.15645553
14MP0002160_abnormal_reproductive_system2.13876896
15MP0005389_reproductive_system_phenotype2.04714993
16MP0008057_abnormal_DNA_replication1.99600320
17MP0005671_abnormal_response_to1.95900730
18MP0003878_abnormal_ear_physiology1.95342841
19MP0005377_hearing/vestibular/ear_phenot1.95342841
20MP0002254_reproductive_system_inflammat1.91010462
21MP0006035_abnormal_mitochondrial_morpho1.89864161
22MP0002277_abnormal_respiratory_mucosa1.89393766
23MP0005379_endocrine/exocrine_gland_phen1.83355379
24MP0003646_muscle_fatigue1.83053459
25MP0001188_hyperpigmentation1.80464770
26MP0003195_calcinosis1.80397209
27MP0003186_abnormal_redox_activity1.75797674
28MP0001919_abnormal_reproductive_system1.74833732
29MP0001727_abnormal_embryo_implantation1.71044937
30MP0008995_early_reproductive_senescence1.67182612
31MP0003718_maternal_effect1.66722625
32MP0003941_abnormal_skin_development1.64284742
33MP0006036_abnormal_mitochondrial_physio1.63059838
34MP0000490_abnormal_crypts_of1.62422866
35MP0001529_abnormal_vocalization1.48110559
36MP0006072_abnormal_retinal_apoptosis1.48019272
37MP0000350_abnormal_cell_proliferation1.39289748
38MP0001293_anophthalmia1.38542339
39MP0003787_abnormal_imprinting1.38102685
40MP0003763_abnormal_thymus_physiology1.36589071
41MP0008877_abnormal_DNA_methylation1.27844146
42MP0003567_abnormal_fetal_cardiomyocyte1.24476083
43MP0008007_abnormal_cellular_replicative1.23906033
44MP0002210_abnormal_sex_determination1.22470474
45MP0000049_abnormal_middle_ear1.21033930
46MP0009785_altered_susceptibility_to1.19431433
47MP0002653_abnormal_ependyma_morphology1.17525454
48MP0000685_abnormal_immune_system1.15424996
49MP0009333_abnormal_splenocyte_physiolog1.15233488
50MP0001485_abnormal_pinna_reflex1.10799328
51MP0001905_abnormal_dopamine_level1.08841270
52MP0009697_abnormal_copulation1.08834926
53MP0000678_abnormal_parathyroid_gland1.08825483
54MP0005410_abnormal_fertilization1.07540732
55MP0003121_genomic_imprinting1.06985396
56MP0002095_abnormal_skin_pigmentation1.05136401
57MP0003806_abnormal_nucleotide_metabolis1.04616281
58MP0001835_abnormal_antigen_presentation1.04204657
59MP0001119_abnormal_female_reproductive1.03541697
60MP0000313_abnormal_cell_death1.02001580
61MP0002398_abnormal_bone_marrow0.99995917
62MP0000703_abnormal_thymus_morphology0.99194273
63MP0004197_abnormal_fetal_growth/weight/0.98865444
64MP0001145_abnormal_male_reproductive0.98170545
65MP0001800_abnormal_humoral_immune0.96418510
66MP0001730_embryonic_growth_arrest0.96060157
67MP0003011_delayed_dark_adaptation0.92667178
68MP0002429_abnormal_blood_cell0.90559443
69MP0001697_abnormal_embryo_size0.90264322
70MP0002019_abnormal_tumor_incidence0.89256858
71MP0005000_abnormal_immune_tolerance0.89093567
72MP0003937_abnormal_limbs/digits/tail_de0.87372345
73MP0000358_abnormal_cell_content/0.87181763
74MP0002723_abnormal_immune_serum0.86140762
75MP0002148_abnormal_hypersensitivity_rea0.84151194
76MP0002736_abnormal_nociception_after0.83850663
77MP0001542_abnormal_bone_strength0.82222445
78MP0002177_abnormal_outer_ear0.82163208
79MP0005310_abnormal_salivary_gland0.81952223
80MP0001881_abnormal_mammary_gland0.80352916
81MP0001929_abnormal_gametogenesis0.79985525
82MP0002085_abnormal_embryonic_tissue0.79311777
83MP0000716_abnormal_immune_system0.79308064
84MP0002080_prenatal_lethality0.78929769
85MP0003942_abnormal_urinary_system0.78906134
86MP0000613_abnormal_salivary_gland0.76266689
87MP0005380_embryogenesis_phenotype0.76202196
88MP0001672_abnormal_embryogenesis/_devel0.76202196
89MP0001968_abnormal_touch/_nociception0.75532103
90MP0000653_abnormal_sex_gland0.75523669
91MP0002452_abnormal_antigen_presenting0.75296705
92MP0001819_abnormal_immune_cell0.73557996
93MP0002722_abnormal_immune_system0.73117629
94MP0002420_abnormal_adaptive_immunity0.72323496
95MP0000689_abnormal_spleen_morphology0.70962666
96MP0005025_abnormal_response_to0.67796242
97MP0002138_abnormal_hepatobiliary_system0.66128944
98MP0000631_abnormal_neuroendocrine_gland0.64207964
99MP0002088_abnormal_embryonic_growth/wei0.64114892
100MP0003984_embryonic_growth_retardation0.63960533

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.61366602
23-Methylglutaconic aciduria (HP:0003535)5.47800882
3Abnormal mitochondria in muscle tissue (HP:0008316)4.97568084
4Acute encephalopathy (HP:0006846)4.90540507
5Progressive macrocephaly (HP:0004481)4.41671710
6Macrocytic anemia (HP:0001972)4.24424636
7Reticulocytopenia (HP:0001896)4.22340445
8Mitochondrial inheritance (HP:0001427)4.21005127
9Testicular atrophy (HP:0000029)4.13630271
10Increased CSF lactate (HP:0002490)3.87991113
11Abnormality of cells of the erythroid lineage (HP:0012130)3.66498924
12Cerebral edema (HP:0002181)3.64387849
13Abnormal number of erythroid precursors (HP:0012131)3.58000967
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.52395597
15Severe visual impairment (HP:0001141)3.35059549
16Pendular nystagmus (HP:0012043)3.22681249
17Increased hepatocellular lipid droplets (HP:0006565)3.20575980
18Hepatocellular necrosis (HP:0001404)3.16152415
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.12398348
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.12398348
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08895945
22Chromsome breakage (HP:0040012)2.97902845
23Meckel diverticulum (HP:0002245)2.93796753
24Pallor (HP:0000980)2.84925254
25Hepatic necrosis (HP:0002605)2.82264500
26Abnormality of the ileum (HP:0001549)2.80096484
27Microvesicular hepatic steatosis (HP:0001414)2.78821304
28Increased serum lactate (HP:0002151)2.74073672
29Lipid accumulation in hepatocytes (HP:0006561)2.71208370
30Sensory axonal neuropathy (HP:0003390)2.70686429
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.70360232
32Abnormality of the preputium (HP:0100587)2.67161670
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.64079370
34Lactic acidosis (HP:0003128)2.62542297
35Septo-optic dysplasia (HP:0100842)2.55632721
36IgG deficiency (HP:0004315)2.55163216
37Megaloblastic anemia (HP:0001889)2.54295925
38Absent thumb (HP:0009777)2.52584838
39Abnormality of chromosome stability (HP:0003220)2.48235394
40Congenital stationary night blindness (HP:0007642)2.46123952
41Premature ovarian failure (HP:0008209)2.44450528
42Abnormality of purine metabolism (HP:0004352)2.43177303
43Respiratory failure (HP:0002878)2.43127538
44Parakeratosis (HP:0001036)2.41137966
45Progressive muscle weakness (HP:0003323)2.40943107
46Progressive external ophthalmoplegia (HP:0000590)2.35141108
47Leukodystrophy (HP:0002415)2.33654681
48Severe combined immunodeficiency (HP:0004430)2.32328925
49Exercise intolerance (HP:0003546)2.29749768
50Abnormality of the carotid arteries (HP:0005344)2.27891486
51Multiple enchondromatosis (HP:0005701)2.26542662
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26293990
53Combined immunodeficiency (HP:0005387)2.23682723
54Ragged-red muscle fibers (HP:0003200)2.22324942
55Hypergonadotropic hypogonadism (HP:0000815)2.20681691
56Pancytopenia (HP:0001876)2.20566704
57Optic disc pallor (HP:0000543)2.18644196
58Renal Fanconi syndrome (HP:0001994)2.16760267
59Methylmalonic aciduria (HP:0012120)2.15297911
60Microretrognathia (HP:0000308)2.12808890
61Methylmalonic acidemia (HP:0002912)2.10721488
62Impulsivity (HP:0100710)2.09793982
63Dysphonia (HP:0001618)2.09453140
64Tracheoesophageal fistula (HP:0002575)2.07875304
65Cleft eyelid (HP:0000625)2.05391591
66Renovascular hypertension (HP:0100817)2.03203028
67Lethargy (HP:0001254)2.02660152
68Pancreatic fibrosis (HP:0100732)2.00733619
69Increased intramyocellular lipid droplets (HP:0012240)1.99426766
70Aplastic anemia (HP:0001915)1.96258782
71Triphalangeal thumb (HP:0001199)1.95366805
72Facial cleft (HP:0002006)1.94956878
73Poor head control (HP:0002421)1.94125892
74Abnormal number of incisors (HP:0011064)1.92141537
75Secondary amenorrhea (HP:0000869)1.91955797
76Gout (HP:0001997)1.91375537
77Small intestinal stenosis (HP:0012848)1.89446835
78Duodenal stenosis (HP:0100867)1.89446835
79Dicarboxylic aciduria (HP:0003215)1.89098999
80Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89098999
81Abnormality of nucleobase metabolism (HP:0010932)1.88433901
82Rough bone trabeculation (HP:0100670)1.87434882
83Emotional lability (HP:0000712)1.87231315
84Rhabdomyosarcoma (HP:0002859)1.86442484
85Abnormal protein glycosylation (HP:0012346)1.83013446
86Abnormal glycosylation (HP:0012345)1.83013446
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83013446
88Abnormal protein N-linked glycosylation (HP:0012347)1.83013446
89Horseshoe kidney (HP:0000085)1.82866404
90Selective tooth agenesis (HP:0001592)1.82782774
91Hypoplasia of the uterus (HP:0000013)1.82674938
92Congenital, generalized hypertrichosis (HP:0004540)1.80495048
93Birth length less than 3rd percentile (HP:0003561)1.79562592
94Sparse eyelashes (HP:0000653)1.79416814
95Clubbing of toes (HP:0100760)1.77449615
96Overriding aorta (HP:0002623)1.77394486
97Resting tremor (HP:0002322)1.76654020
98Oral leukoplakia (HP:0002745)1.76399803
99Cellular immunodeficiency (HP:0005374)1.73099237
100Sclerocornea (HP:0000647)1.65686432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.85580326
2NME24.25309980
3TXK3.61641364
4MST43.53688191
5BUB13.35768469
6NME12.87440808
7LIMK12.83543373
8VRK22.69888731
9EIF2AK12.56809512
10PLK42.45958390
11SMG12.10026455
12SRPK12.04591926
13TTK1.83357025
14MAP4K11.78258119
15IRAK41.74322839
16KDR1.70770554
17BCKDK1.69678306
18DYRK31.67554398
19CDK81.66505260
20NUAK11.57051265
21CDC42BPA1.54562462
22CAMK1D1.52211071
23NEK11.47359424
24MKNK11.40534416
25AURKA1.35424177
26ADRBK21.34239950
27BRSK11.30484937
28PBK1.29311307
29ZAK1.26728982
30TESK21.26610085
31PLK31.26218249
32PLK11.25945484
33ALK1.25913324
34DYRK21.24966436
35VRK11.20212500
36TNIK1.18460791
37AURKB1.13525430
38CHEK21.10257012
39ATR1.05367764
40CAMK1G1.02655484
41CDK41.01382321
42CAMKK20.99818421
43TSSK60.96431685
44ABL20.95161516
45CSNK2A20.94602897
46CHEK10.94010809
47TAF10.93975937
48BRSK20.88473371
49NEK20.87187180
50ARAF0.85466126
51STK160.84475599
52RPS6KA50.81192338
53CLK10.80460753
54GRK10.79902974
55CSNK2A10.79840353
56PASK0.77192901
57EIF2AK30.76558209
58MKNK20.75678677
59MAP3K110.75150256
60MATK0.74070479
61RPS6KA40.67389726
62TAOK20.64306799
63TIE10.62651805
64CAMK10.56307236
65MAPK110.55260311
66KIT0.54355065
67JAK30.53015953
68CSNK1E0.52613488
69RPS6KB20.51877016
70CDK190.51087086
71CDK10.47690415
72ITK0.46066888
73CDK20.45136786
74IRAK20.41881740
75TLK10.41866834
76WEE10.41546145
77IKBKB0.39823217
78ATM0.38771786
79IRAK30.38523059
80EIF2AK20.38330290
81RPS6KA10.38248571
82CDK70.37713455
83BRAF0.37537478
84PIK3CG0.35711191
85CDK30.35036891
86IKBKE0.33718531
87MAP3K90.33661211
88MAP2K70.33620207
89TEC0.32530464
90PRKCI0.32467537
91PDK20.31429560
92FGR0.30290637
93DDR20.29789589
94MAPK140.28089399
95PIM10.27864242
96PAK10.26985869
97PIM20.26339365
98STK40.25177142
99LCK0.24957598
100PRKG20.24934619

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.98606129
2Oxidative phosphorylation_Homo sapiens_hsa001903.78527734
3Proteasome_Homo sapiens_hsa030503.53363186
4DNA replication_Homo sapiens_hsa030303.52949692
5Parkinsons disease_Homo sapiens_hsa050123.23986772
6Spliceosome_Homo sapiens_hsa030403.20066100
7RNA polymerase_Homo sapiens_hsa030203.13852823
8Homologous recombination_Homo sapiens_hsa034403.12936938
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87962082
10Mismatch repair_Homo sapiens_hsa034302.82372989
11Sulfur metabolism_Homo sapiens_hsa009202.77636661
12Protein export_Homo sapiens_hsa030602.45795795
13Huntingtons disease_Homo sapiens_hsa050162.31984779
14Alzheimers disease_Homo sapiens_hsa050102.10363638
15Pyrimidine metabolism_Homo sapiens_hsa002402.07865187
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06463765
17One carbon pool by folate_Homo sapiens_hsa006701.98534898
18Fanconi anemia pathway_Homo sapiens_hsa034601.97807356
19RNA transport_Homo sapiens_hsa030131.94430572
20RNA degradation_Homo sapiens_hsa030181.94221657
21Basal transcription factors_Homo sapiens_hsa030221.87491361
22Nucleotide excision repair_Homo sapiens_hsa034201.83364521
23Selenocompound metabolism_Homo sapiens_hsa004501.82404685
24Sulfur relay system_Homo sapiens_hsa041221.62633679
25Primary immunodeficiency_Homo sapiens_hsa053401.55370911
26Base excision repair_Homo sapiens_hsa034101.43195976
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42339101
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.42142232
29Cardiac muscle contraction_Homo sapiens_hsa042601.35929646
30Purine metabolism_Homo sapiens_hsa002301.28371260
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27528744
32Cell cycle_Homo sapiens_hsa041101.24001447
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23194536
34Non-homologous end-joining_Homo sapiens_hsa034501.18284913
35Folate biosynthesis_Homo sapiens_hsa007901.11196688
36mRNA surveillance pathway_Homo sapiens_hsa030151.04402578
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91758230
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87304615
39Autoimmune thyroid disease_Homo sapiens_hsa053200.86654055
40Allograft rejection_Homo sapiens_hsa053300.86094074
41Epstein-Barr virus infection_Homo sapiens_hsa051690.80081763
42Vitamin B6 metabolism_Homo sapiens_hsa007500.78310912
43Glutathione metabolism_Homo sapiens_hsa004800.74745064
44Caffeine metabolism_Homo sapiens_hsa002320.74678160
45Tryptophan metabolism_Homo sapiens_hsa003800.73745269
46Graft-versus-host disease_Homo sapiens_hsa053320.68214912
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66538353
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65943872
49Linoleic acid metabolism_Homo sapiens_hsa005910.65639436
50Vitamin digestion and absorption_Homo sapiens_hsa049770.63461563
51Herpes simplex infection_Homo sapiens_hsa051680.62954587
52Type I diabetes mellitus_Homo sapiens_hsa049400.62849066
53Metabolic pathways_Homo sapiens_hsa011000.62344959
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61559974
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61541398
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.57388625
57Antigen processing and presentation_Homo sapiens_hsa046120.57219954
58Pyruvate metabolism_Homo sapiens_hsa006200.56354240
59p53 signaling pathway_Homo sapiens_hsa041150.55034894
60Propanoate metabolism_Homo sapiens_hsa006400.53804402
61Asthma_Homo sapiens_hsa053100.52125036
62Olfactory transduction_Homo sapiens_hsa047400.51210601
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49962648
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45983112
65Butanoate metabolism_Homo sapiens_hsa006500.40398225
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39769953
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.37330126
68Phototransduction_Homo sapiens_hsa047440.36809337
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35544865
70Fatty acid elongation_Homo sapiens_hsa000620.34935405
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33594219
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32993036
73Systemic lupus erythematosus_Homo sapiens_hsa053220.30152793
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28938432
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28797458
76Steroid biosynthesis_Homo sapiens_hsa001000.24843069
77Arachidonic acid metabolism_Homo sapiens_hsa005900.24074259
78Rheumatoid arthritis_Homo sapiens_hsa053230.23005695
79Measles_Homo sapiens_hsa051620.21449531
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18154673
81Hematopoietic cell lineage_Homo sapiens_hsa046400.17872898
82HTLV-I infection_Homo sapiens_hsa051660.17442400
83Viral carcinogenesis_Homo sapiens_hsa052030.16920357
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16491348
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15291806
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15024705
87Fat digestion and absorption_Homo sapiens_hsa049750.15017338
88Basal cell carcinoma_Homo sapiens_hsa052170.14379011
89N-Glycan biosynthesis_Homo sapiens_hsa005100.14374393
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.13575767
91Galactose metabolism_Homo sapiens_hsa000520.12976346
92Ether lipid metabolism_Homo sapiens_hsa005650.11357234
93Viral myocarditis_Homo sapiens_hsa054160.10692547
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.10380687
95Shigellosis_Homo sapiens_hsa051310.10264390
96Biosynthesis of amino acids_Homo sapiens_hsa012300.09952538
97Oocyte meiosis_Homo sapiens_hsa041140.07738350
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.06381533
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.05060473
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.04865410

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