ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	8.10039024
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.01393780
3	viral transcription (GO:0019083)	5.74668201
4	DNA damage response, detection of DNA damage (GO:0042769)	5.54142524
5	translational termination (GO:0006415)	5.52673962
6	ribosomal small subunit assembly (GO:0000028)	5.38704525
7	tolerance induction (GO:0002507)	4.99187251
8	ribosomal small subunit biogenesis (GO:0042274)	4.84665683
9	ATP synthesis coupled proton transport (GO:0015986)	4.64886771
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.64886771
11	translational elongation (GO:0006414)	4.51435073
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.41444966
13	termination of RNA polymerase III transcription (GO:0006386)	4.37774332
14	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.37774332
15	cotranslational protein targeting to membrane (GO:0006613)	4.34421903
16	protein targeting to ER (GO:0045047)	4.33513727
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.32776772
18	GTP biosynthetic process (GO:0006183)	4.24072050
19	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.16855751
20	cellular protein complex disassembly (GO:0043624)	4.12134111
21	viral life cycle (GO:0019058)	4.06589068
22	UTP metabolic process (GO:0046051)	4.03610953
23	activated T cell proliferation (GO:0050798)	4.03453421
24	negative regulation of histone acetylation (GO:0035067)	4.00537295
25	translational initiation (GO:0006413)	3.98452941
26	DNA replication checkpoint (GO:0000076)	3.97640147
27	protein localization to endoplasmic reticulum (GO:0070972)	3.97346628
28	pre-miRNA processing (GO:0031054)	3.94095430
29	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.94016611
30	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.89700100
31	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.89700100
32	regulation of translation, ncRNA-mediated (GO:0045974)	3.89700100
33	protein neddylation (GO:0045116)	3.85823316
34	negative regulation of T cell mediated immunity (GO:0002710)	3.80553437
35	UTP biosynthetic process (GO:0006228)	3.79297436
36	chaperone-mediated protein transport (GO:0072321)	3.77256609
37	negative regulation of telomerase activity (GO:0051974)	3.74489616
38	intra-S DNA damage checkpoint (GO:0031573)	3.70429754
39	respiratory electron transport chain (GO:0022904)	3.67156279
40	protein complex disassembly (GO:0043241)	3.63234484
41	positive regulation of gamma-delta T cell activation (GO:0046645)	3.57468316
42	electron transport chain (GO:0022900)	3.56396650
43	spliceosomal complex assembly (GO:0000245)	3.45862948
44	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.41211496
45	regulation of interleukin-2 biosynthetic process (GO:0045076)	3.40688522
46	chromatin remodeling at centromere (GO:0031055)	3.40144363
47	regulation of alpha-beta T cell proliferation (GO:0046640)	3.37085311
48	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.35462653
49	regulation of isotype switching to IgG isotypes (GO:0048302)	3.35287887
50	macromolecular complex disassembly (GO:0032984)	3.32856574
51	CENP-A containing nucleosome assembly (GO:0034080)	3.31391162
52	negative regulation of interleukin-2 production (GO:0032703)	3.29289496
53	interferon-gamma production (GO:0032609)	3.25609148
54	negative regulation of peptidyl-lysine acetylation (GO:2000757)	3.21512841
55	regulation of gamma-delta T cell differentiation (GO:0045586)	3.20951135
56	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.20602290
57	negative regulation of B cell apoptotic process (GO:0002903)	3.17137391
58	regulation of regulatory T cell differentiation (GO:0045589)	3.14141670
59	cellular response to interleukin-15 (GO:0071350)	3.09677559
60	morphogenesis of an endothelium (GO:0003159)	3.09650077
61	endothelial tube morphogenesis (GO:0061154)	3.09650077
62	mRNA catabolic process (GO:0006402)	3.04211694
63	positive regulation of tolerance induction (GO:0002645)	3.04150600
64	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	3.03656550
65	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	3.03656550
66	translation (GO:0006412)	3.01696958
67	response to interleukin-15 (GO:0070672)	3.01149779
68	pericardium development (GO:0060039)	3.00193359
69	guanosine-containing compound biosynthetic process (GO:1901070)	2.99759383
70	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.98721722
71	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.96601013
72	positive regulation of T cell differentiation in thymus (GO:0033089)	2.95898998
73	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.94154417
74	negative regulation of protein acetylation (GO:1901984)	2.93242073
75	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.92197476
76	regulation of gamma-delta T cell activation (GO:0046643)	2.92063945
77	L-fucose catabolic process (GO:0042355)	2.85178422
78	fucose catabolic process (GO:0019317)	2.85178422
79	L-fucose metabolic process (GO:0042354)	2.85178422
80	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.79031751
81	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.79031751
82	maturation of SSU-rRNA (GO:0030490)	2.77971699
83	RNA catabolic process (GO:0006401)	2.75864250
84	protein targeting to membrane (GO:0006612)	2.75769897
85	regulation of interleukin-5 production (GO:0032674)	2.73297109
86	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.71264442
87	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	2.70268632
88	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.67624381
89	histone mRNA metabolic process (GO:0008334)	2.67116101
90	spliceosomal snRNP assembly (GO:0000387)	2.66610193
91	CTP biosynthetic process (GO:0006241)	2.66069088
92	CTP metabolic process (GO:0046036)	2.66069088
93	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.60807341
94	positive regulation of mRNA catabolic process (GO:0061014)	2.60317748
95	negative regulation by host of viral transcription (GO:0043922)	2.57757633
96	DNA replication-independent nucleosome assembly (GO:0006336)	2.56376543
97	DNA replication-independent nucleosome organization (GO:0034724)	2.56376543
98	negative T cell selection (GO:0043383)	2.55654367
99	negative thymic T cell selection (GO:0045060)	2.52767767
100	positive regulation of defense response to virus by host (GO:0002230)	2.51876680

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.46278955
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.36985017
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.86152008
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.77103051
5	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.38622933
6	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.28054420
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.25819082
8	EZH2_22144423_ChIP-Seq_EOC_Human	3.18483050
9	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.12027602
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.00667184
11	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.98744870
12	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.98744870
13	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.98744870
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.94355052
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.73311319
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.66805485
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.65210353
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.60796834
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.60227253
20	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.50982027
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.33531739
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.32520786
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.26286977
24	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.25456607
25	VDR_23849224_ChIP-Seq_CD4+_Human	2.25353541
26	MAF_26560356_Chip-Seq_TH1_Human	2.16765645
27	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.07185833
28	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.03180436
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.03144990
30	MAF_26560356_Chip-Seq_TH2_Human	1.99619040
31	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.91980564
32	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.84214013
33	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.83500924
34	MYC_22102868_ChIP-Seq_BL_Human	1.81063926
35	MYB_26560356_Chip-Seq_TH2_Human	1.78327442
36	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.77343586
37	VDR_21846776_ChIP-Seq_THP-1_Human	1.74610233
38	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.72947471
39	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.70012478
40	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.68845026
41	RUNX_20019798_ChIP-Seq_JUKART_Human	1.65023749
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.63661972
43	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.63303605
44	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.63033786
45	MYB_26560356_Chip-Seq_TH1_Human	1.62584022
46	XRN2_22483619_ChIP-Seq_HELA_Human	1.58547672
47	VDR_22108803_ChIP-Seq_LS180_Human	1.58472735
48	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.54443385
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50608632
50	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.46855950
51	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.43532802
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.40102714
53	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.38317409
54	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.34905607
55	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.34184885
56	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.29596622
57	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.28848759
58	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.28597427
59	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.26456918
60	DCP1A_22483619_ChIP-Seq_HELA_Human	1.25042811
61	UTX_26944678_Chip-Seq_JUKART_Human	1.23938278
62	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20691117
63	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.19711285
64	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.19081344
65	VDR_24763502_ChIP-Seq_THP-1_Human	1.15428413
66	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.15134231
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.13600722
68	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.12392367
69	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11616641
70	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.10238999
71	SCL_19346495_ChIP-Seq_HPC-7_Human	1.09278581
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.09039249
73	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.06876761
74	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.06484427
75	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.03751632
76	KDM2B_26808549_Chip-Seq_DND41_Human	1.03632686
77	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.03476179
78	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.00728623
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.00113190
80	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.99605961
81	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.99392767
82	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	0.99384859
83	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.97610110
84	KDM5A_27292631_Chip-Seq_BREAST_Human	0.96752750
85	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96057689
86	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.95551264
87	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94699604
88	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.92654611
89	STAT1_20625510_ChIP-Seq_HELA_Human	0.89514597
90	SPI1_23547873_ChIP-Seq_NB4_Human	0.89442011
91	GATA3_26560356_Chip-Seq_TH2_Human	0.88429937
92	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.87171175
93	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.84872748
94	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.84710257
95	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.84071990
96	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.83930436
97	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.83481330
98	CIITA_25753668_ChIP-Seq_RAJI_Human	0.83307346
99	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.82451709
100	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.81677187

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002277_abnormal_respiratory_mucosa	3.43495552
2	MP0003300_gastrointestinal_ulcer	3.22462240
3	MP0009379_abnormal_foot_pigmentation	3.07857639
4	MP0008057_abnormal_DNA_replication	2.87786162
5	MP0002138_abnormal_hepatobiliary_system	2.84406552
6	MP0005451_abnormal_body_composition	2.66428566
7	MP0005310_abnormal_salivary_gland	2.55624189
8	MP0003763_abnormal_thymus_physiology	2.43994377
9	MP0005671_abnormal_response_to	2.39340134
10	MP0005377_hearing/vestibular/ear_phenot	2.34654376
11	MP0003878_abnormal_ear_physiology	2.34654376
12	MP0001968_abnormal_touch/_nociception	2.32781832
13	MP0010094_abnormal_chromosome_stability	2.30014642
14	MP0001873_stomach_inflammation	2.25139639
15	MP0001529_abnormal_vocalization	2.20537227
16	MP0009333_abnormal_splenocyte_physiolog	2.16497486
17	MP0000703_abnormal_thymus_morphology	2.02145122
18	MP0002736_abnormal_nociception_after	1.92297294
19	MP0001800_abnormal_humoral_immune	1.72837380
20	MP0002398_abnormal_bone_marrow	1.69595085
21	MP0003077_abnormal_cell_cycle	1.67330958
22	MP0004142_abnormal_muscle_tone	1.67063652
23	MP0002735_abnormal_chemical_nociception	1.66531682
24	MP0010386_abnormal_urinary_bladder	1.63838285
25	MP0002396_abnormal_hematopoietic_system	1.60822043
26	MP0002733_abnormal_thermal_nociception	1.58832803
27	MP0003866_abnormal_defecation	1.57849168
28	MP0003567_abnormal_fetal_cardiomyocyte	1.56006456
29	MP0001790_abnormal_immune_system	1.55715505
30	MP0005387_immune_system_phenotype	1.55715505
31	MP0002420_abnormal_adaptive_immunity	1.55117308
32	MP0002722_abnormal_immune_system	1.50709169
33	MP0001819_abnormal_immune_cell	1.49895887
34	MP0004185_abnormal_adipocyte_glucose	1.48226643
35	MP0008058_abnormal_DNA_repair	1.44982378
36	MP0000689_abnormal_spleen_morphology	1.43899000
37	MP0000716_abnormal_immune_system	1.43141399
38	MP0006292_abnormal_olfactory_placode	1.42867279
39	MP0005000_abnormal_immune_tolerance	1.41732558
40	MP0002127_abnormal_cardiovascular_syste	1.41071916
41	MP0000490_abnormal_crypts_of	1.38832020
42	MP0003941_abnormal_skin_development	1.38766727
43	MP0003786_premature_aging	1.37916409
44	MP0003436_decreased_susceptibility_to	1.37306179
45	MP0003693_abnormal_embryo_hatching	1.37073168
46	MP0002723_abnormal_immune_serum	1.35036729
47	MP0008007_abnormal_cellular_replicative	1.33719688
48	MP0001919_abnormal_reproductive_system	1.31538875
49	MP0004957_abnormal_blastocyst_morpholog	1.31478111
50	MP0003315_abnormal_perineum_morphology	1.27867196
51	MP0008995_early_reproductive_senescence	1.27861453
52	MP0009745_abnormal_behavioral_response	1.27684108
53	MP0003111_abnormal_nucleus_morphology	1.26352447
54	MP0008569_lethality_at_weaning	1.26197167
55	MP0004134_abnormal_chest_morphology	1.23340517
56	MP0002006_tumorigenesis	1.20720258
57	MP0001835_abnormal_antigen_presentation	1.18692133
58	MP0002405_respiratory_system_inflammati	1.18218346
59	MP0002452_abnormal_antigen_presenting	1.17807545
60	MP0008961_abnormal_basal_metabolism	1.16513531
61	MP0002734_abnormal_mechanical_nocicepti	1.11569099
62	MP0004808_abnormal_hematopoietic_stem	1.09664585
63	MP0002429_abnormal_blood_cell	1.08478318
64	MP0000685_abnormal_immune_system	1.00535338
65	MP0006072_abnormal_retinal_apoptosis	0.97588668
66	MP0001188_hyperpigmentation	0.96768961
67	MP0006035_abnormal_mitochondrial_morpho	0.95918063
68	MP0002933_joint_inflammation	0.95450921
69	MP0003890_abnormal_embryonic-extraembry	0.94736834
70	MP0001970_abnormal_pain_threshold	0.93780459
71	MP0003045_fibrosis	0.92109823
72	MP0002751_abnormal_autonomic_nervous	0.90670212
73	MP0005025_abnormal_response_to	0.89946626
74	MP0003787_abnormal_imprinting	0.89634609
75	MP0001879_abnormal_lymphatic_vessel	0.86798560
76	MP0004947_skin_inflammation	0.84657823
77	MP0009250_abnormal_appendicular_skeleto	0.84337522
78	MP0003724_increased_susceptibility_to	0.83396441
79	MP0002876_abnormal_thyroid_physiology	0.82793891
80	MP0001764_abnormal_homeostasis	0.80397551
81	MP0001984_abnormal_olfaction	0.80013920
82	MP0001851_eye_inflammation	0.78484464
83	MP0004885_abnormal_endolymph	0.78108012
84	MP0002067_abnormal_sensory_capabilities	0.77551194
85	MP0001905_abnormal_dopamine_level	0.77495289
86	MP0002928_abnormal_bile_duct	0.74620259
87	MP0002019_abnormal_tumor_incidence	0.73469971
88	MP0005389_reproductive_system_phenotype	0.73458211
89	MP0000470_abnormal_stomach_morphology	0.73035359
90	MP0002419_abnormal_innate_immunity	0.72783079
91	MP0003252_abnormal_bile_duct	0.72356809
92	MP0001340_abnormal_eyelid_morphology	0.71470299
93	MP0000026_abnormal_inner_ear	0.69052230
94	MP0000350_abnormal_cell_proliferation	0.68814033
95	MP0005408_hypopigmentation	0.67480526
96	MP0004510_myositis	0.66809429
97	MP0001486_abnormal_startle_reflex	0.66476319
98	MP0005551_abnormal_eye_electrophysiolog	0.65929059
99	MP0000681_abnormal_thyroid_gland	0.64641471
100	MP0003936_abnormal_reproductive_system	0.63648288

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	5.72110253
2	Lipid accumulation in hepatocytes (HP:0006561)	5.19558059
3	Renal Fanconi syndrome (HP:0001994)	4.99569225
4	Genetic anticipation (HP:0003743)	4.70637897
5	Exertional dyspnea (HP:0002875)	4.64782099
6	Reticulocytopenia (HP:0001896)	3.88472115
7	Mitochondrial inheritance (HP:0001427)	3.82659110
8	Acute necrotizing encephalopathy (HP:0006965)	3.81161684
9	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.80948731
10	Respiratory difficulties (HP:0002880)	3.78948529
11	Abnormality of macular pigmentation (HP:0008002)	3.72611461
12	Abnormality of cells of the erythroid lineage (HP:0012130)	3.62765702
13	Increased intramyocellular lipid droplets (HP:0012240)	3.56794646
14	Abnormal number of erythroid precursors (HP:0012131)	3.54871159
15	Hepatocellular necrosis (HP:0001404)	3.52700775
16	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.28941975
17	Abnormal mitochondria in muscle tissue (HP:0008316)	3.23564723
18	Progressive macrocephaly (HP:0004481)	3.18705969
19	Increased muscle lipid content (HP:0009058)	3.12462069
20	Segmental peripheral demyelination/remyelination (HP:0003481)	3.09007003
21	Hepatic necrosis (HP:0002605)	3.08566016
22	Abnormality of renal resorption (HP:0011038)	3.03681087
23	IgM deficiency (HP:0002850)	2.98748789
24	Increased CSF lactate (HP:0002490)	2.98581520
25	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.98266499
26	Macrocytic anemia (HP:0001972)	2.97916424
27	Retrobulbar optic neuritis (HP:0100654)	2.93502713
28	Optic neuritis (HP:0100653)	2.93502713
29	Pallor (HP:0000980)	2.80256515
30	Chronic hepatic failure (HP:0100626)	2.70916504
31	Progressive cerebellar ataxia (HP:0002073)	2.68188416
32	Spondylolisthesis (HP:0003302)	2.68081795
33	Acute encephalopathy (HP:0006846)	2.59824572
34	Congenital, generalized hypertrichosis (HP:0004540)	2.57140907
35	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.55643164
36	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.52764847
37	Abnormality of placental membranes (HP:0011409)	2.44206637
38	Amniotic constriction ring (HP:0009775)	2.44206637
39	Orchitis (HP:0100796)	2.43799601
40	Abnormality of the parietal bone (HP:0002696)	2.41458096
41	Stomatitis (HP:0010280)	2.38363782
42	Decreased central vision (HP:0007663)	2.36986914
43	Hypochromic microcytic anemia (HP:0004840)	2.35661654
44	Myositis (HP:0100614)	2.35404982
45	Hyperphosphaturia (HP:0003109)	2.31595109
46	Pendular nystagmus (HP:0012043)	2.30020817
47	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.29012956
48	Abnormality of binocular vision (HP:0011514)	2.25430356
49	Diplopia (HP:0000651)	2.25430356
50	Abnormality of the pubic bones (HP:0003172)	2.23616535
51	Concave nail (HP:0001598)	2.21960136
52	Cerebral edema (HP:0002181)	2.20470363
53	Short middle phalanx of the 5th finger (HP:0004220)	2.20463812
54	Septo-optic dysplasia (HP:0100842)	2.13329721
55	Protruding tongue (HP:0010808)	2.03845615
56	Ileus (HP:0002595)	2.02189734
57	Keratoconjunctivitis sicca (HP:0001097)	2.01997624
58	Autoimmune thrombocytopenia (HP:0001973)	2.01995229
59	Retinal dysplasia (HP:0007973)	2.01550091
60	Syringomyelia (HP:0003396)	2.01072150
61	Spinal cord lesions (HP:0100561)	2.01072150
62	Severe visual impairment (HP:0001141)	2.01013312
63	Pancreatic cysts (HP:0001737)	1.99740738
64	Impaired smooth pursuit (HP:0007772)	1.96758578
65	Conjunctival hamartoma (HP:0100780)	1.96256827
66	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.95633338
67	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.95633338
68	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.95210109
69	Autoimmune hemolytic anemia (HP:0001890)	1.91684477
70	Supernumerary bones of the axial skeleton (HP:0009144)	1.89312391
71	Pheochromocytoma (HP:0002666)	1.88626658
72	Supernumerary ribs (HP:0005815)	1.87050388
73	Ulnar claw (HP:0001178)	1.85189724
74	Abnormality of the frontal sinuses (HP:0002687)	1.84266094
75	Exercise intolerance (HP:0003546)	1.83048885
76	Selective tooth agenesis (HP:0001592)	1.81142841
77	Abnormal urine phosphate concentration (HP:0012599)	1.80212370
78	Encephalitis (HP:0002383)	1.76462597
79	Abnormality of T cell number (HP:0011839)	1.76084122
80	Abnormality of the lacrimal duct (HP:0011481)	1.75949727
81	Anorexia (HP:0002039)	1.75760227
82	Oral leukoplakia (HP:0002745)	1.73131498
83	Colon cancer (HP:0003003)	1.73096991
84	Keratoconjunctivitis (HP:0001096)	1.73058637
85	Broad face (HP:0000283)	1.72000500
86	Hypochromic anemia (HP:0001931)	1.70536564
87	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.69480976
88	Neuroendocrine neoplasm (HP:0100634)	1.68618070
89	Glycosuria (HP:0003076)	1.68335758
90	Abnormality of urine glucose concentration (HP:0011016)	1.68335758
91	Nasolacrimal duct obstruction (HP:0000579)	1.67965384
92	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.67879900
93	Abnormality of alanine metabolism (HP:0010916)	1.67879900
94	Hyperalaninemia (HP:0003348)	1.67879900
95	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.67435820
96	T lymphocytopenia (HP:0005403)	1.67156214
97	11 pairs of ribs (HP:0000878)	1.66914716
98	Obstructive sleep apnea (HP:0002870)	1.66197470
99	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.65590399
100	Gliosis (HP:0002171)	1.64566464

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.72564907
2	TLK1	4.61307840
3	VRK2	3.97537761
4	SIK2	3.09887917
5	SIK3	3.00458993
6	TNIK	2.90960448
7	DYRK3	2.63080353
8	STK16	2.62960342
9	MAP4K1	2.28799895
10	TAF1	2.13580879
11	NME2	1.98733003
12	SIK1	1.94373900
13	HIPK2	1.89699797
14	CDK12	1.83272818
15	VRK1	1.81551632
16	SMG1	1.77321053
17	MST4	1.77209340
18	MARK3	1.75294481
19	ACVR1B	1.73036376
20	CDC7	1.68943647
21	TAOK1	1.63015670
22	BUB1	1.62704949
23	DYRK1B	1.59778189
24	DYRK2	1.49501149
25	RPS6KA4	1.45220690
26	PASK	1.39106657
27	MARK2	1.31058031
28	TYRO3	1.25882604
29	BTK	1.23356430
30	MAP3K11	1.19668556
31	SGK494	1.09906672
32	SGK223	1.09906672
33	ITK	1.07415948
34	IRAK4	1.06139465
35	GRK6	1.05330568
36	SGK2	1.05109077
37	MAP2K3	1.00950423
38	IKBKE	0.99737826
39	FES	0.99206617
40	CAMK1D	0.93741603
41	PIM1	0.93645653
42	MAP3K10	0.92079165
43	TNK2	0.90420160
44	MAPK7	0.87061160
45	BRD4	0.85592479
46	HCK	0.84659472
47	SYK	0.84658874
48	STK4	0.84579922
49	ATR	0.82563719
50	CSK	0.80634513
51	PBK	0.80016972
52	ADRBK2	0.75819688
53	LCK	0.74215501
54	MELK	0.73307733
55	ZAP70	0.72706072
56	STK24	0.70195946
57	CAMK1G	0.68247957
58	TEC	0.66709260
59	CCNB1	0.66411277
60	MAP3K12	0.65924907
61	CSNK1G2	0.63127622
62	SGK3	0.62415099
63	NUAK1	0.59968212
64	PRPF4B	0.58767644
65	RPS6KA5	0.57873498
66	PRKCQ	0.56767574
67	BMPR1B	0.53172438
68	CAMKK2	0.52820372
69	SRPK1	0.51739854
70	CASK	0.50650285
71	EIF2AK3	0.48697216
72	EIF2AK2	0.48130241
73	NME1	0.47813280
74	CDK7	0.47712075
75	PNCK	0.47465716
76	NLK	0.46564465
77	CDK6	0.46346993
78	CDK4	0.45290990
79	CHUK	0.44601117
80	MAP3K5	0.44562410
81	CAMK4	0.43075906
82	MAPK12	0.40106136
83	CSNK1A1L	0.39179518
84	AURKA	0.38577213
85	CSNK1G3	0.36400913
86	CHEK2	0.35047375
87	LYN	0.34593126
88	CDK3	0.33314085
89	TYK2	0.33291462
90	UHMK1	0.33275215
91	RPS6KA6	0.31307898
92	MOS	0.31068438
93	PRKCH	0.29406446
94	CAMKK1	0.29077304
95	PLK3	0.28084110
96	MAP2K4	0.26920729
97	RPS6KL1	0.26884066
98	RPS6KC1	0.26884066
99	ATM	0.26548435
100	PLK1	0.24874012

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.47629814
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.03137084
3	RNA polymerase_Homo sapiens_hsa03020	3.73307757
4	Parkinsons disease_Homo sapiens_hsa05012	3.29269912
5	DNA replication_Homo sapiens_hsa03030	2.80748470
6	Huntingtons disease_Homo sapiens_hsa05016	2.70543234
7	Spliceosome_Homo sapiens_hsa03040	2.69601063
8	Mismatch repair_Homo sapiens_hsa03430	2.46965935
9	Proteasome_Homo sapiens_hsa03050	2.45945539
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.40955232
11	Alzheimers disease_Homo sapiens_hsa05010	2.34310014
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.26805370
13	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.15318116
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.01453926
15	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.71523877
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.62639703
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.60083810
18	Nicotine addiction_Homo sapiens_hsa05033	1.53358999
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.48609813
20	Homologous recombination_Homo sapiens_hsa03440	1.45515894
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.44147759
22	Base excision repair_Homo sapiens_hsa03410	1.43202011
23	Primary immunodeficiency_Homo sapiens_hsa05340	1.41016941
24	Folate biosynthesis_Homo sapiens_hsa00790	1.40911736
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.39929031
26	mRNA surveillance pathway_Homo sapiens_hsa03015	1.35805826
27	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.34248370
28	Protein export_Homo sapiens_hsa03060	1.31432973
29	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.27301501
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25816370
31	RNA degradation_Homo sapiens_hsa03018	1.25657223
32	One carbon pool by folate_Homo sapiens_hsa00670	1.22024914
33	Cell cycle_Homo sapiens_hsa04110	1.16688037
34	Circadian rhythm_Homo sapiens_hsa04710	1.12288784
35	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.11458236
36	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.07547335
37	Viral carcinogenesis_Homo sapiens_hsa05203	1.03030069
38	Basal transcription factors_Homo sapiens_hsa03022	1.02195127
39	Measles_Homo sapiens_hsa05162	0.97571195
40	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.96617995
41	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.94813392
42	RNA transport_Homo sapiens_hsa03013	0.92437939
43	Alcoholism_Homo sapiens_hsa05034	0.91712609
44	Purine metabolism_Homo sapiens_hsa00230	0.89994218
45	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.83402242
46	Morphine addiction_Homo sapiens_hsa05032	0.83093273
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81152254
48	Renal cell carcinoma_Homo sapiens_hsa05211	0.80584356
49	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.77145176
50	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.73587915
51	Osteoclast differentiation_Homo sapiens_hsa04380	0.71421505
52	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.71071339
53	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.69461195
54	Hepatitis B_Homo sapiens_hsa05161	0.63877631
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.62922992
56	HTLV-I infection_Homo sapiens_hsa05166	0.62457269
57	p53 signaling pathway_Homo sapiens_hsa04115	0.62409998
58	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.60917795
59	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.60913527
60	Non-small cell lung cancer_Homo sapiens_hsa05223	0.57541454
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51889387
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51821744
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.51491760
64	Prostate cancer_Homo sapiens_hsa05215	0.51175573
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.50125819
66	Cocaine addiction_Homo sapiens_hsa05030	0.46285450
67	Herpes simplex infection_Homo sapiens_hsa05168	0.44784597
68	MAPK signaling pathway_Homo sapiens_hsa04010	0.44777071
69	Acute myeloid leukemia_Homo sapiens_hsa05221	0.44631148
70	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.43965706
71	Notch signaling pathway_Homo sapiens_hsa04330	0.42938542
72	ErbB signaling pathway_Homo sapiens_hsa04012	0.37471389
73	Phototransduction_Homo sapiens_hsa04744	0.35493007
74	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.32266987
75	Serotonergic synapse_Homo sapiens_hsa04726	0.29782488
76	TNF signaling pathway_Homo sapiens_hsa04668	0.29688634
77	Metabolic pathways_Homo sapiens_hsa01100	0.29451815
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29449738
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.28589416
80	Peroxisome_Homo sapiens_hsa04146	0.28577851
81	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.28442047
82	Chemokine signaling pathway_Homo sapiens_hsa04062	0.27220356
83	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.27057523
84	Taste transduction_Homo sapiens_hsa04742	0.25708562
85	Wnt signaling pathway_Homo sapiens_hsa04310	0.24910069
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.23902801
87	Pancreatic cancer_Homo sapiens_hsa05212	0.23577071
88	Selenocompound metabolism_Homo sapiens_hsa00450	0.21554927
89	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.20637437
90	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.20545870
91	GABAergic synapse_Homo sapiens_hsa04727	0.20047658
92	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.20012546
93	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.19826189
94	Ras signaling pathway_Homo sapiens_hsa04014	0.18365537
95	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.17767734
96	Cholinergic synapse_Homo sapiens_hsa04725	0.17028602
97	Melanoma_Homo sapiens_hsa05218	0.16220828
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.16184870
99	Antigen processing and presentation_Homo sapiens_hsa04612	0.15759084
100	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.12594199

HNRNPA3P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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