Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.57789982 |
2 | chaperone-mediated protein transport (GO:0072321) | 5.38577617 |
3 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.97301984 |
4 | ATP synthesis coupled proton transport (GO:0015986) | 4.95082815 |
5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.95082815 |
6 | rRNA modification (GO:0000154) | 4.79592584 |
7 | rRNA methylation (GO:0031167) | 4.60676591 |
8 | respiratory electron transport chain (GO:0022904) | 4.59722559 |
9 | proteasome assembly (GO:0043248) | 4.53265980 |
10 | electron transport chain (GO:0022900) | 4.51098913 |
11 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.38308692 |
12 | sequestering of actin monomers (GO:0042989) | 4.36334907 |
13 | maturation of SSU-rRNA (GO:0030490) | 4.24461616 |
14 | protein neddylation (GO:0045116) | 4.23562400 |
15 | DNA deamination (GO:0045006) | 4.17907689 |
16 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.16474381 |
17 | termination of RNA polymerase III transcription (GO:0006386) | 4.16474381 |
18 | respiratory chain complex IV assembly (GO:0008535) | 4.14911943 |
19 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.05639457 |
20 | viral transcription (GO:0019083) | 3.99272548 |
21 | translational termination (GO:0006415) | 3.98147771 |
22 | ribosomal small subunit biogenesis (GO:0042274) | 3.97760215 |
23 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.97015097 |
24 | cotranslational protein targeting to membrane (GO:0006613) | 3.92673761 |
25 | protein targeting to ER (GO:0045047) | 3.91142769 |
26 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.88472415 |
27 | protein complex biogenesis (GO:0070271) | 3.82710917 |
28 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.79065817 |
29 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.73960478 |
30 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.70980038 |
31 | protein localization to endoplasmic reticulum (GO:0070972) | 3.65996105 |
32 | establishment of integrated proviral latency (GO:0075713) | 3.65483691 |
33 | regulation of mitochondrial translation (GO:0070129) | 3.65189519 |
34 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.62282475 |
35 | NADH dehydrogenase complex assembly (GO:0010257) | 3.62282475 |
36 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.62282475 |
37 | regulation of gene silencing by RNA (GO:0060966) | 3.44172319 |
38 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.44172319 |
39 | regulation of gene silencing by miRNA (GO:0060964) | 3.44172319 |
40 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.43532895 |
41 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.43186542 |
42 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.43186542 |
43 | translation (GO:0006412) | 3.39751404 |
44 | DNA damage response, detection of DNA damage (GO:0042769) | 3.37638947 |
45 | translational elongation (GO:0006414) | 3.37158360 |
46 | spliceosomal snRNP assembly (GO:0000387) | 3.31451417 |
47 | cytochrome complex assembly (GO:0017004) | 3.27858448 |
48 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.19620211 |
49 | anterograde synaptic vesicle transport (GO:0048490) | 3.13439952 |
50 | chromatin remodeling at centromere (GO:0031055) | 3.13207393 |
51 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.11179649 |
52 | viral life cycle (GO:0019058) | 3.08804989 |
53 | rRNA processing (GO:0006364) | 3.07990419 |
54 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.07516233 |
55 | translational initiation (GO:0006413) | 3.06865789 |
56 | pseudouridine synthesis (GO:0001522) | 3.06422733 |
57 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.06373658 |
58 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.05932416 |
59 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.05932416 |
60 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.05932416 |
61 | rRNA metabolic process (GO:0016072) | 3.05710754 |
62 | protein targeting to mitochondrion (GO:0006626) | 3.04960564 |
63 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.04413412 |
64 | ribosomal small subunit assembly (GO:0000028) | 3.02945449 |
65 | negative regulation of ligase activity (GO:0051352) | 3.02817736 |
66 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.02817736 |
67 | hydrogen ion transmembrane transport (GO:1902600) | 3.01096344 |
68 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.00943118 |
69 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.00943118 |
70 | cellular protein complex disassembly (GO:0043624) | 3.00573348 |
71 | transcription from mitochondrial promoter (GO:0006390) | 2.99796117 |
72 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.98649190 |
73 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.96527561 |
74 | establishment of protein localization to mitochondrion (GO:0072655) | 2.92312082 |
75 | histone mRNA metabolic process (GO:0008334) | 2.91625564 |
76 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.91092267 |
77 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.91092267 |
78 | epithelial cilium movement (GO:0003351) | 2.89467329 |
79 | amino acid salvage (GO:0043102) | 2.89217880 |
80 | L-methionine salvage (GO:0071267) | 2.89217880 |
81 | L-methionine biosynthetic process (GO:0071265) | 2.89217880 |
82 | DNA double-strand break processing (GO:0000729) | 2.89008664 |
83 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.88778066 |
84 | histone H4-K12 acetylation (GO:0043983) | 2.87734696 |
85 | CENP-A containing nucleosome assembly (GO:0034080) | 2.86660218 |
86 | establishment of viral latency (GO:0019043) | 2.84695994 |
87 | peptidyl-histidine modification (GO:0018202) | 2.80719447 |
88 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.79035928 |
89 | regulation of helicase activity (GO:0051095) | 2.78352497 |
90 | ribosomal large subunit biogenesis (GO:0042273) | 2.78223046 |
91 | inner mitochondrial membrane organization (GO:0007007) | 2.78121986 |
92 | ATP biosynthetic process (GO:0006754) | 2.76729096 |
93 | protein localization to mitochondrion (GO:0070585) | 2.76278835 |
94 | proton transport (GO:0015992) | 2.75445316 |
95 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.74478098 |
96 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.74335816 |
97 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.74335816 |
98 | tRNA processing (GO:0008033) | 2.72141270 |
99 | oxidative phosphorylation (GO:0006119) | 2.72014908 |
100 | hydrogen transport (GO:0006818) | 2.71924418 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.98607848 |
2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.33693255 |
3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.12441156 |
4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.07615400 |
5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.17506811 |
6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.14173243 |
7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.99387925 |
8 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.87528198 |
9 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.68073044 |
10 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.66498804 |
11 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.59294799 |
12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.57968139 |
13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.47716738 |
14 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.46843781 |
15 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.45944018 |
16 | VDR_22108803_ChIP-Seq_LS180_Human | 2.44001732 |
17 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.40796751 |
18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.40284840 |
19 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.37378376 |
20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.34689844 |
21 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.32917220 |
22 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.32094155 |
23 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 2.31949877 |
24 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.12471122 |
25 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.05642833 |
26 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.04872176 |
27 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.98736698 |
28 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.97599665 |
29 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.92902325 |
30 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.86879592 |
31 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.81737207 |
32 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.78930855 |
33 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.73776994 |
34 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.72770770 |
35 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.71454235 |
36 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.69791413 |
37 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.68919120 |
38 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.63080105 |
39 | EWS_26573619_Chip-Seq_HEK293_Human | 1.63072466 |
40 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.58959491 |
41 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.52940346 |
42 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.47426432 |
43 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.46672500 |
44 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.46539766 |
45 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.43180367 |
46 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.37891957 |
47 | FUS_26573619_Chip-Seq_HEK293_Human | 1.37077298 |
48 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.33599501 |
49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.33376991 |
50 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.33062894 |
51 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.32582539 |
52 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.27337175 |
53 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.26791300 |
54 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.26370145 |
55 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.26210886 |
56 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.17501826 |
57 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.17388279 |
58 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.16653701 |
59 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.16630661 |
60 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.15211761 |
61 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.12057580 |
62 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.11381808 |
63 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.09176730 |
64 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.08917778 |
65 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.08728194 |
66 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.08724892 |
67 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.06338901 |
68 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.05871131 |
69 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.05554479 |
70 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.05262512 |
71 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.04280047 |
72 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.03437364 |
73 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.02793753 |
74 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.01626833 |
75 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.01626833 |
76 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.00583095 |
77 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.99850952 |
78 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.99473512 |
79 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.98747697 |
80 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.96674995 |
81 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.94338806 |
82 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.93176414 |
83 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.93063814 |
84 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.92851789 |
85 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.91695240 |
86 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.91336366 |
87 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.91152757 |
88 | P300_19829295_ChIP-Seq_ESCs_Human | 0.89885543 |
89 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.88748410 |
90 | AR_20517297_ChIP-Seq_VCAP_Human | 0.88037168 |
91 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.87264648 |
92 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.86916722 |
93 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.85596103 |
94 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.83732534 |
95 | NCOR_22424771_ChIP-Seq_293T_Human | 0.80875660 |
96 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.79719470 |
97 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.78858985 |
98 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.78700496 |
99 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.76092299 |
100 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.75511782 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0006292_abnormal_olfactory_placode | 6.42460243 |
2 | MP0009379_abnormal_foot_pigmentation | 3.55340266 |
3 | MP0008789_abnormal_olfactory_epithelium | 3.26529679 |
4 | MP0001188_hyperpigmentation | 2.92918545 |
5 | MP0003136_yellow_coat_color | 2.76516652 |
6 | MP0002938_white_spotting | 2.73432640 |
7 | MP0003878_abnormal_ear_physiology | 2.72157070 |
8 | MP0005377_hearing/vestibular/ear_phenot | 2.72157070 |
9 | MP0002277_abnormal_respiratory_mucosa | 2.51204946 |
10 | MP0004885_abnormal_endolymph | 2.43232886 |
11 | MP0002736_abnormal_nociception_after | 2.33785393 |
12 | MP0005394_taste/olfaction_phenotype | 2.30269758 |
13 | MP0005499_abnormal_olfactory_system | 2.30269758 |
14 | MP0003195_calcinosis | 2.17384415 |
15 | MP0002234_abnormal_pharynx_morphology | 2.01942556 |
16 | MP0003693_abnormal_embryo_hatching | 1.98044523 |
17 | MP0000372_irregular_coat_pigmentation | 1.96160994 |
18 | MP0001968_abnormal_touch/_nociception | 1.94753135 |
19 | MP0005084_abnormal_gallbladder_morpholo | 1.92964861 |
20 | MP0006072_abnormal_retinal_apoptosis | 1.85989274 |
21 | MP0003786_premature_aging | 1.81985113 |
22 | MP0002138_abnormal_hepatobiliary_system | 1.81901925 |
23 | MP0001293_anophthalmia | 1.78977606 |
24 | MP0008877_abnormal_DNA_methylation | 1.75503710 |
25 | MP0004133_heterotaxia | 1.65124678 |
26 | MP0002139_abnormal_hepatobiliary_system | 1.64840513 |
27 | MP0008058_abnormal_DNA_repair | 1.63690624 |
28 | MP0008995_early_reproductive_senescence | 1.60759259 |
29 | MP0004957_abnormal_blastocyst_morpholog | 1.58952614 |
30 | MP0005671_abnormal_response_to | 1.57954191 |
31 | MP0003718_maternal_effect | 1.56300190 |
32 | MP0001485_abnormal_pinna_reflex | 1.55700499 |
33 | MP0004147_increased_porphyrin_level | 1.55541375 |
34 | MP0003186_abnormal_redox_activity | 1.53974857 |
35 | MP0003567_abnormal_fetal_cardiomyocyte | 1.52254464 |
36 | MP0010094_abnormal_chromosome_stability | 1.48488235 |
37 | MP0000569_abnormal_digit_pigmentation | 1.42076900 |
38 | MP0003787_abnormal_imprinting | 1.37530546 |
39 | MP0000631_abnormal_neuroendocrine_gland | 1.35930142 |
40 | MP0005174_abnormal_tail_pigmentation | 1.35824516 |
41 | MP0004185_abnormal_adipocyte_glucose | 1.34021452 |
42 | MP0000049_abnormal_middle_ear | 1.29953911 |
43 | MP0005551_abnormal_eye_electrophysiolog | 1.29484605 |
44 | MP0003011_delayed_dark_adaptation | 1.26764128 |
45 | MP0009697_abnormal_copulation | 1.22224624 |
46 | MP0005408_hypopigmentation | 1.17327946 |
47 | MP0001727_abnormal_embryo_implantation | 1.13151397 |
48 | MP0003283_abnormal_digestive_organ | 1.13135960 |
49 | MP0003121_genomic_imprinting | 1.08002975 |
50 | MP0006036_abnormal_mitochondrial_physio | 1.06637650 |
51 | MP0002638_abnormal_pupillary_reflex | 1.04298224 |
52 | MP0003938_abnormal_ear_development | 1.04240375 |
53 | MP0008932_abnormal_embryonic_tissue | 1.03333972 |
54 | MP0004142_abnormal_muscle_tone | 1.03300278 |
55 | MP0001905_abnormal_dopamine_level | 1.02347456 |
56 | MP0006276_abnormal_autonomic_nervous | 0.97159879 |
57 | MP0001324_abnormal_eye_pigmentation | 0.95027707 |
58 | MP0002653_abnormal_ependyma_morphology | 0.94947022 |
59 | MP0005645_abnormal_hypothalamus_physiol | 0.93264999 |
60 | MP0005365_abnormal_bile_salt | 0.91411688 |
61 | MP0002184_abnormal_innervation | 0.90385300 |
62 | MP0001286_abnormal_eye_development | 0.89113378 |
63 | MP0001984_abnormal_olfaction | 0.88969929 |
64 | MP0000566_synostosis | 0.86423066 |
65 | MP0002006_tumorigenesis | 0.86175291 |
66 | MP0002095_abnormal_skin_pigmentation | 0.85482607 |
67 | MP0000778_abnormal_nervous_system | 0.85034540 |
68 | MP0009745_abnormal_behavioral_response | 0.84641589 |
69 | MP0005195_abnormal_posterior_eye | 0.83291980 |
70 | MP0002735_abnormal_chemical_nociception | 0.83272389 |
71 | MP0003880_abnormal_central_pattern | 0.81823505 |
72 | MP0003646_muscle_fatigue | 0.81258672 |
73 | MP0003077_abnormal_cell_cycle | 0.80787710 |
74 | MP0002067_abnormal_sensory_capabilities | 0.80309024 |
75 | MP0005389_reproductive_system_phenotype | 0.79718848 |
76 | MP0002233_abnormal_nose_morphology | 0.79448074 |
77 | MP0005253_abnormal_eye_physiology | 0.78590247 |
78 | MP0001919_abnormal_reproductive_system | 0.75945245 |
79 | MP0005395_other_phenotype | 0.75655947 |
80 | MP0003941_abnormal_skin_development | 0.75540816 |
81 | MP0003111_abnormal_nucleus_morphology | 0.75431060 |
82 | MP0002177_abnormal_outer_ear | 0.72221391 |
83 | MP0004742_abnormal_vestibular_system | 0.72028953 |
84 | MP0002102_abnormal_ear_morphology | 0.71907671 |
85 | MP0008875_abnormal_xenobiotic_pharmacok | 0.71860969 |
86 | MP0008872_abnormal_physiological_respon | 0.71779411 |
87 | MP0000026_abnormal_inner_ear | 0.71635961 |
88 | MP0006035_abnormal_mitochondrial_morpho | 0.70192631 |
89 | MP0001529_abnormal_vocalization | 0.69916410 |
90 | MP0002751_abnormal_autonomic_nervous | 0.68413470 |
91 | MP0002733_abnormal_thermal_nociception | 0.67296770 |
92 | MP0000579_abnormal_nail_morphology | 0.66134917 |
93 | MP0005075_abnormal_melanosome_morpholog | 0.65967873 |
94 | MP0003252_abnormal_bile_duct | 0.65789841 |
95 | MP0002210_abnormal_sex_determination | 0.65738602 |
96 | MP0002272_abnormal_nervous_system | 0.65702365 |
97 | MP0009333_abnormal_splenocyte_physiolog | 0.65625675 |
98 | MP0003119_abnormal_digestive_system | 0.63933647 |
99 | MP0002752_abnormal_somatic_nervous | 0.63592690 |
100 | MP0003937_abnormal_limbs/digits/tail_de | 0.62325437 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Increased hepatocellular lipid droplets (HP:0006565) | 4.77673644 |
2 | Acute necrotizing encephalopathy (HP:0006965) | 4.72241222 |
3 | 3-Methylglutaconic aciduria (HP:0003535) | 4.62503015 |
4 | Mitochondrial inheritance (HP:0001427) | 4.32579514 |
5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.23695843 |
6 | Lipid accumulation in hepatocytes (HP:0006561) | 4.23350324 |
7 | Increased CSF lactate (HP:0002490) | 3.88329045 |
8 | Acute encephalopathy (HP:0006846) | 3.85754899 |
9 | Progressive macrocephaly (HP:0004481) | 3.83746671 |
10 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.73166133 |
11 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.57806975 |
12 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.57105085 |
13 | Absent/shortened dynein arms (HP:0200106) | 3.57105085 |
14 | Renal Fanconi syndrome (HP:0001994) | 3.49386368 |
15 | Reticulocytopenia (HP:0001896) | 3.28900697 |
16 | Hepatocellular necrosis (HP:0001404) | 3.24795066 |
17 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.17941393 |
18 | Congenital, generalized hypertrichosis (HP:0004540) | 3.13672723 |
19 | Increased intramyocellular lipid droplets (HP:0012240) | 3.10691317 |
20 | Hepatic necrosis (HP:0002605) | 3.07884508 |
21 | Adrenal hypoplasia (HP:0000835) | 2.90055345 |
22 | Septo-optic dysplasia (HP:0100842) | 2.89856141 |
23 | Cerebral edema (HP:0002181) | 2.85305457 |
24 | Chronic bronchitis (HP:0004469) | 2.84500342 |
25 | Abnormal number of incisors (HP:0011064) | 2.83866264 |
26 | Pancreatic fibrosis (HP:0100732) | 2.77860956 |
27 | Exertional dyspnea (HP:0002875) | 2.74817853 |
28 | Abnormal number of erythroid precursors (HP:0012131) | 2.66381031 |
29 | Congenital stationary night blindness (HP:0007642) | 2.65778147 |
30 | Increased serum lactate (HP:0002151) | 2.60705347 |
31 | Parakeratosis (HP:0001036) | 2.54673514 |
32 | Respiratory difficulties (HP:0002880) | 2.51661292 |
33 | Macrocytic anemia (HP:0001972) | 2.50591282 |
34 | Pancreatic cysts (HP:0001737) | 2.49275758 |
35 | Hyperphosphaturia (HP:0003109) | 2.48963597 |
36 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.46897410 |
37 | True hermaphroditism (HP:0010459) | 2.46118240 |
38 | Glycosuria (HP:0003076) | 2.42970838 |
39 | Abnormality of urine glucose concentration (HP:0011016) | 2.42970838 |
40 | Optic disc pallor (HP:0000543) | 2.42822600 |
41 | Increased muscle lipid content (HP:0009058) | 2.41538909 |
42 | Type II lissencephaly (HP:0007260) | 2.40551025 |
43 | Pendular nystagmus (HP:0012043) | 2.33892417 |
44 | Abnormality of renal resorption (HP:0011038) | 2.32462416 |
45 | Lactic acidosis (HP:0003128) | 2.30379480 |
46 | Abnormality of midbrain morphology (HP:0002418) | 2.29820491 |
47 | Molar tooth sign on MRI (HP:0002419) | 2.29820491 |
48 | Duplicated collecting system (HP:0000081) | 2.29503429 |
49 | Abnormality of placental membranes (HP:0011409) | 2.28727461 |
50 | Amniotic constriction ring (HP:0009775) | 2.28727461 |
51 | Exercise intolerance (HP:0003546) | 2.28112297 |
52 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.27661110 |
53 | Nephronophthisis (HP:0000090) | 2.23082294 |
54 | Abnormality of the renal collecting system (HP:0004742) | 2.20073012 |
55 | Oral leukoplakia (HP:0002745) | 2.19653245 |
56 | Methylmalonic acidemia (HP:0002912) | 2.17649605 |
57 | Lethargy (HP:0001254) | 2.17175178 |
58 | Constricted visual fields (HP:0001133) | 2.14638940 |
59 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.12982718 |
60 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.12982718 |
61 | Methylmalonic aciduria (HP:0012120) | 2.10673861 |
62 | Leukodystrophy (HP:0002415) | 2.10248938 |
63 | IgG deficiency (HP:0004315) | 2.07364978 |
64 | Homocystinuria (HP:0002156) | 2.06354907 |
65 | Abnormality of homocysteine metabolism (HP:0010919) | 2.06354907 |
66 | Abnormal biliary tract physiology (HP:0012439) | 2.05698011 |
67 | Bile duct proliferation (HP:0001408) | 2.05698011 |
68 | Respiratory failure (HP:0002878) | 2.04885550 |
69 | Rib fusion (HP:0000902) | 2.01345644 |
70 | Abnormality of DNA repair (HP:0003254) | 1.99443391 |
71 | Absent septum pellucidum (HP:0001331) | 1.97501971 |
72 | Aplastic anemia (HP:0001915) | 1.97202388 |
73 | Abnormality of T cell number (HP:0011839) | 1.94855080 |
74 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.93281611 |
75 | Abnormality of the pons (HP:0007361) | 1.91550903 |
76 | Severe combined immunodeficiency (HP:0004430) | 1.89000483 |
77 | Severe visual impairment (HP:0001141) | 1.87508603 |
78 | Abnormality of the metopic suture (HP:0005556) | 1.86974357 |
79 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.83042524 |
80 | Abnormal ciliary motility (HP:0012262) | 1.82403079 |
81 | Maternal diabetes (HP:0009800) | 1.81530937 |
82 | T lymphocytopenia (HP:0005403) | 1.81209211 |
83 | Abnormality of chromosome stability (HP:0003220) | 1.81206010 |
84 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.78235769 |
85 | Renal cortical cysts (HP:0000803) | 1.78134741 |
86 | Papilledema (HP:0001085) | 1.76440310 |
87 | Esophageal atresia (HP:0002032) | 1.75696056 |
88 | Sclerocornea (HP:0000647) | 1.75480900 |
89 | Optic nerve hypoplasia (HP:0000609) | 1.74549247 |
90 | Abnormal urine phosphate concentration (HP:0012599) | 1.74366999 |
91 | Hypoplasia of the uterus (HP:0000013) | 1.73172929 |
92 | Meckel diverticulum (HP:0002245) | 1.72084485 |
93 | Absent thumb (HP:0009777) | 1.72016853 |
94 | Abnormal lung lobation (HP:0002101) | 1.71948779 |
95 | Abnormal pupillary function (HP:0007686) | 1.71652139 |
96 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.69891556 |
97 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.69524861 |
98 | Holoprosencephaly (HP:0001360) | 1.68713024 |
99 | Large for gestational age (HP:0001520) | 1.67743963 |
100 | Ectopic kidney (HP:0000086) | 1.67222370 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 4.83159269 |
2 | TXK | 4.33136050 |
3 | CDK19 | 3.73072242 |
4 | MAP4K2 | 3.49726023 |
5 | NME1 | 3.22826340 |
6 | CDC7 | 2.74348875 |
7 | DYRK2 | 2.68241547 |
8 | NUAK1 | 2.33188465 |
9 | TLK1 | 2.28491135 |
10 | ZAK | 2.18842485 |
11 | MAP3K12 | 2.11425683 |
12 | BUB1 | 2.01139674 |
13 | STK16 | 1.89539334 |
14 | VRK1 | 1.85718416 |
15 | GRK1 | 1.76006271 |
16 | TAF1 | 1.61188999 |
17 | MST4 | 1.51096495 |
18 | MKNK1 | 1.46279973 |
19 | ADRBK2 | 1.44428108 |
20 | BCKDK | 1.39638423 |
21 | NME2 | 1.36979890 |
22 | TTK | 1.30439119 |
23 | ITK | 1.24386045 |
24 | PINK1 | 1.21045474 |
25 | MKNK2 | 1.20105800 |
26 | NEK1 | 1.18801059 |
27 | SRPK1 | 1.17410185 |
28 | TIE1 | 1.17210041 |
29 | CAMK1D | 1.16746790 |
30 | WNK4 | 1.15899607 |
31 | KDR | 1.14689814 |
32 | PASK | 1.14013034 |
33 | MAP4K1 | 1.13525037 |
34 | MAPKAPK5 | 1.12595068 |
35 | DYRK3 | 1.12366688 |
36 | PLK3 | 1.10912538 |
37 | OXSR1 | 1.07069531 |
38 | TSSK6 | 1.06297182 |
39 | CSNK1G3 | 1.04339679 |
40 | WNK3 | 1.02171202 |
41 | CAMK1G | 1.00948184 |
42 | CSNK1G1 | 1.00276289 |
43 | BRSK2 | 0.99278892 |
44 | WEE1 | 0.95156020 |
45 | PBK | 0.91213257 |
46 | CSNK1G2 | 0.90603097 |
47 | TEC | 0.89813247 |
48 | MARK3 | 0.88003732 |
49 | CSNK1A1L | 0.87212901 |
50 | PRKCQ | 0.83303149 |
51 | TYRO3 | 0.83277437 |
52 | ALK | 0.83255543 |
53 | PLK1 | 0.81674652 |
54 | NEK2 | 0.75777323 |
55 | EIF2AK1 | 0.74391056 |
56 | PIK3CG | 0.71616387 |
57 | MAP3K11 | 0.69038560 |
58 | AURKB | 0.68973961 |
59 | EPHA3 | 0.62837266 |
60 | GRK5 | 0.61119832 |
61 | CHEK2 | 0.61049583 |
62 | CSNK2A2 | 0.59362643 |
63 | PIM1 | 0.59022389 |
64 | AURKA | 0.57215230 |
65 | IRAK1 | 0.56792485 |
66 | PRKCE | 0.53946331 |
67 | PLK4 | 0.53620839 |
68 | CDK3 | 0.53246212 |
69 | CSNK2A1 | 0.52958935 |
70 | ATR | 0.50512314 |
71 | ABL2 | 0.49184043 |
72 | CSNK1A1 | 0.48969708 |
73 | ERBB4 | 0.48631009 |
74 | DAPK1 | 0.47547043 |
75 | CCNB1 | 0.47216461 |
76 | EIF2AK3 | 0.45737147 |
77 | ADRBK1 | 0.42058308 |
78 | PRKCH | 0.41388674 |
79 | MATK | 0.40117992 |
80 | RPS6KA5 | 0.38627653 |
81 | CSNK1E | 0.38367495 |
82 | PRKCG | 0.37864183 |
83 | EIF2AK2 | 0.37139636 |
84 | PRKCI | 0.36530891 |
85 | CAMK2A | 0.35632882 |
86 | PRKACA | 0.35344070 |
87 | CAMK1 | 0.34105402 |
88 | BCR | 0.33582174 |
89 | BTK | 0.33334584 |
90 | NLK | 0.32719437 |
91 | TESK2 | 0.31265397 |
92 | PLK2 | 0.31119152 |
93 | MYLK | 0.29581751 |
94 | CHEK1 | 0.29506892 |
95 | PNCK | 0.29476960 |
96 | TNIK | 0.28863229 |
97 | EPHB2 | 0.27156202 |
98 | STK39 | 0.26766389 |
99 | MAPKAPK3 | 0.26654520 |
100 | CDK7 | 0.26191323 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ribosome_Homo sapiens_hsa03010 | 4.18394515 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.07713537 |
3 | Proteasome_Homo sapiens_hsa03050 | 3.99439043 |
4 | Protein export_Homo sapiens_hsa03060 | 3.91409035 |
5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.64264333 |
6 | RNA polymerase_Homo sapiens_hsa03020 | 2.93595377 |
7 | Homologous recombination_Homo sapiens_hsa03440 | 2.63975485 |
8 | Huntingtons disease_Homo sapiens_hsa05016 | 2.42590206 |
9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.28427837 |
10 | Alzheimers disease_Homo sapiens_hsa05010 | 2.20734113 |
11 | Spliceosome_Homo sapiens_hsa03040 | 2.17746032 |
12 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.09458785 |
13 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.05915008 |
14 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.88219857 |
15 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.87206797 |
16 | Mismatch repair_Homo sapiens_hsa03430 | 1.81403410 |
17 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.79562511 |
18 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.73084918 |
19 | RNA degradation_Homo sapiens_hsa03018 | 1.67751927 |
20 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.50612976 |
21 | DNA replication_Homo sapiens_hsa03030 | 1.49191982 |
22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.44499965 |
23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.37398923 |
24 | Phototransduction_Homo sapiens_hsa04744 | 1.34566023 |
25 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.33330176 |
26 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.27373857 |
27 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.22994219 |
28 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.16504185 |
29 | RNA transport_Homo sapiens_hsa03013 | 1.13748017 |
30 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.13398934 |
31 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.04871682 |
32 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.04328557 |
33 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.01185902 |
34 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.01020099 |
35 | Base excision repair_Homo sapiens_hsa03410 | 1.00060056 |
36 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.98164099 |
37 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.98151109 |
38 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.96336686 |
39 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.95513510 |
40 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.93287469 |
41 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.92615511 |
42 | Purine metabolism_Homo sapiens_hsa00230 | 0.86568326 |
43 | Peroxisome_Homo sapiens_hsa04146 | 0.84689069 |
44 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.84476707 |
45 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.84470375 |
46 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.82534000 |
47 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.81989523 |
48 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.81558141 |
49 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.81310715 |
50 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.81083206 |
51 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.80642832 |
52 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.77026235 |
53 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.76194382 |
54 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.76107537 |
55 | Retinol metabolism_Homo sapiens_hsa00830 | 0.73126330 |
56 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.72951738 |
57 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.71260595 |
58 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.70295000 |
59 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.70178317 |
60 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.69079510 |
61 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.68968041 |
62 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68208877 |
63 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.65032736 |
64 | Sulfur relay system_Homo sapiens_hsa04122 | 0.62831571 |
65 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.62755212 |
66 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.61645818 |
67 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.57270813 |
68 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.55079196 |
69 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.54819237 |
70 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.50378077 |
71 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.49748087 |
72 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.48612404 |
73 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.48551769 |
74 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.45621946 |
75 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.45279013 |
76 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.43174636 |
77 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.42517884 |
78 | Allograft rejection_Homo sapiens_hsa05330 | 0.42017808 |
79 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.41794425 |
80 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.41771760 |
81 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.40606773 |
82 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.40393479 |
83 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.37428492 |
84 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.36863146 |
85 | Olfactory transduction_Homo sapiens_hsa04740 | 0.36568215 |
86 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.36477053 |
87 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.36297909 |
88 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.33296725 |
89 | Nicotine addiction_Homo sapiens_hsa05033 | 0.32369963 |
90 | Cell cycle_Homo sapiens_hsa04110 | 0.32057602 |
91 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.30506541 |
92 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.29121653 |
93 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.27909294 |
94 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.27747851 |
95 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.27078850 |
96 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.26117950 |
97 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.25529686 |
98 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.25500286 |
99 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.24767570 |
100 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.24679859 |