ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	natural killer cell activation involved in immune response (GO:0002323)	9.61723543
2	cardiovascular system development (GO:0072358)	9.54601625
3	regulation of helicase activity (GO:0051095)	9.34445193
4	positive regulation of SMAD protein import into nucleus (GO:0060391)	8.51879344
5	pre-miRNA processing (GO:0031054)	8.27372377
6	retina layer formation (GO:0010842)	8.08570195
7	DNA topological change (GO:0006265)	7.86732718
8	digestive tract morphogenesis (GO:0048546)	7.59761662
9	positive regulation of hair cycle (GO:0042635)	6.93765735
10	positive regulation of hair follicle development (GO:0051798)	6.93765735
11	monoubiquitinated protein deubiquitination (GO:0035520)	6.88398824
12	regulation of SMAD protein import into nucleus (GO:0060390)	6.83972258
13	phosphatidylglycerol biosynthetic process (GO:0006655)	6.75647768
14	positive regulation of osteoblast proliferation (GO:0033690)	6.57951760
15	proximal/distal pattern formation (GO:0009954)	6.33599826
16	pituitary gland development (GO:0021983)	5.99954674
17	long-chain fatty acid biosynthetic process (GO:0042759)	5.85049465
18	mating behavior (GO:0007617)	5.78665697
19	sulfur amino acid catabolic process (GO:0000098)	5.77331932
20	CDP-diacylglycerol biosynthetic process (GO:0016024)	5.74558591
21	negative regulation of cell size (GO:0045792)	5.73594600
22	positive regulation of smoothened signaling pathway (GO:0045880)	5.71952722
23	ovulation cycle (GO:0042698)	5.66057406
24	angiogenesis involved in wound healing (GO:0060055)	5.43770030
25	positive regulation of regulated secretory pathway (GO:1903307)	5.21507248
26	peptidyl-lysine dimethylation (GO:0018027)	5.17878361
27	cerebellar granule cell differentiation (GO:0021707)	5.09041087
28	CDP-diacylglycerol metabolic process (GO:0046341)	5.04760868
29	regulation of hair follicle development (GO:0051797)	5.00542677
30	regulation of apoptotic cell clearance (GO:2000425)	4.89039900
31	cell migration in hindbrain (GO:0021535)	4.84944935
32	regulation of B cell receptor signaling pathway (GO:0050855)	4.80274632
33	cellular response to dsRNA (GO:0071359)	4.68151007
34	negative regulation of glial cell proliferation (GO:0060253)	4.58901207
35	sodium-independent organic anion transport (GO:0043252)	4.55724476
36	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	4.55635998
37	negative regulation of phagocytosis (GO:0050765)	4.48119490
38	histone H3-K9 demethylation (GO:0033169)	4.40845271
39	ncRNA catabolic process (GO:0034661)	4.38035398
40	negative regulation of defense response to virus (GO:0050687)	4.29079322
41	carbohydrate phosphorylation (GO:0046835)	4.28890520
42	regulation of activation of Janus kinase activity (GO:0010533)	4.25593457
43	histone H3-K36 demethylation (GO:0070544)	4.15324043
44	positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)	4.15142890
45	positive regulation of neurological system process (GO:0031646)	4.03246078
46	melanocyte differentiation (GO:0030318)	4.03003482
47	lipoxygenase pathway (GO:0019372)	4.02182180
48	regulation of Cdc42 GTPase activity (GO:0043088)	3.97019718
49	ATP synthesis coupled proton transport (GO:0015986)	3.90213128
50	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.90213128
51	regulation of regulated secretory pathway (GO:1903305)	3.88715471
52	DNA integration (GO:0015074)	3.81121570
53	glycoprotein catabolic process (GO:0006516)	3.81075359
54	positive regulation of viral genome replication (GO:0045070)	3.80219628
55	regulation of glial cell proliferation (GO:0060251)	3.67235824
56	pathway-restricted SMAD protein phosphorylation (GO:0060389)	3.63523284
57	melanosome transport (GO:0032402)	3.62610848
58	negative regulation of mast cell activation (GO:0033004)	3.59292780
59	white fat cell differentiation (GO:0050872)	3.59142640
60	pigment granule transport (GO:0051904)	3.54753232
61	pigment cell differentiation (GO:0050931)	3.52576520
62	regulation of interleukin-12 biosynthetic process (GO:0045075)	3.51734307
63	establishment of melanosome localization (GO:0032401)	3.44064953
64	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.42682770
65	establishment of pigment granule localization (GO:0051905)	3.37355316
66	leukocyte degranulation (GO:0043299)	3.34666655
67	negative regulation of response to biotic stimulus (GO:0002832)	3.31417958
68	ATP hydrolysis coupled proton transport (GO:0015991)	3.30898966
69	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.30898966
70	negative regulation of canonical Wnt signaling pathway (GO:0090090)	3.29229388
71	regulation of spindle organization (GO:0090224)	3.26953220
72	mitotic cytokinesis (GO:0000281)	3.19942474
73	melanosome localization (GO:0032400)	3.19405518
74	pigment granule localization (GO:0051875)	3.14219030
75	regulation of hair cycle (GO:0042634)	3.13887307
76	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.13790986
77	apoptotic cell clearance (GO:0043277)	3.13574309
78	regulation of collateral sprouting (GO:0048670)	3.11420258
79	nucleoside diphosphate catabolic process (GO:0009134)	3.11288400
80	tongue development (GO:0043586)	3.10880524
81	neuroepithelial cell differentiation (GO:0060563)	3.10393835
82	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.06593485
83	regulation of plasminogen activation (GO:0010755)	3.05436727
84	pyrimidine nucleotide catabolic process (GO:0006244)	3.04002318
85	dorsal/ventral pattern formation (GO:0009953)	3.03769560
86	natural killer cell activation (GO:0030101)	2.94566878
87	negative regulation of Wnt signaling pathway (GO:0030178)	2.93611075
88	regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)	2.92610376
89	regulation of defense response to virus by host (GO:0050691)	2.90573069
90	homocysteine metabolic process (GO:0050667)	2.84759412
91	histone H3-K9 methylation (GO:0051567)	2.81342175
92	regulation of cilium movement (GO:0003352)	2.80952800
93	sulfur compound catabolic process (GO:0044273)	2.70707163
94	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.63731421
95	negative regulation of B cell proliferation (GO:0030889)	2.62650477
96	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.61815343
97	positive regulation of epidermis development (GO:0045684)	2.58978755
98	anatomical structure regression (GO:0060033)	11.5641388
99	cellular response to exogenous dsRNA (GO:0071360)	10.8461696
100	fructose metabolic process (GO:0006000)	10.2740427

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	8.96506067
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.77245883
3	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	3.63833498
4	DROSHA_22980978_ChIP-Seq_HELA_Human	3.09911431
5	JARID2_20064375_ChIP-Seq_MESCs_Mouse	3.07205751
6	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.97934827
7	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.97934827
8	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.85000239
9	RNF2_27304074_Chip-Seq_NSC_Mouse	2.71843637
10	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.71725642
11	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.58553126
12	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.43572219
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.30751934
14	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.26214967
15	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.25536568
16	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.22856940
17	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.19324914
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.19246205
19	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.19129194
20	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.12004393
21	RING1B_27294783_Chip-Seq_NPCs_Mouse	2.04309557
22	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.02007190
23	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	2.00160811
24	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.97683940
25	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.96973630
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.94697055
27	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.80457909
28	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.78928593
29	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.77450566
30	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.76904800
31	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.76825954
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.73551930
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73551930
34	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.60792429
35	VDR_22108803_ChIP-Seq_LS180_Human	1.58489074
36	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.55367986
37	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.52953549
38	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.48969478
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45134297
40	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.42926029
41	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.40897500
42	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.37133808
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.37019207
44	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.36512241
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36185674
46	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.33981076
47	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.28236131
48	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.26667403
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26426245
50	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22464425
51	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13164763
52	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.10842315
53	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.09832163
54	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.07787217
55	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.07724423
56	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	1.07575507
57	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.05591163
58	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.05112150
59	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.03452380
60	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.03352349
61	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.02687524
62	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98921768
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.96141229
64	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.93438506
65	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93316068
66	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.92765702
67	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.92765702
68	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.92765702
69	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.92696908
70	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.92199194
71	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.91511524
72	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.90278672
73	REST_21632747_ChIP-Seq_MESCs_Mouse	0.88736862
74	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.86503913
75	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.85018077
76	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.83558123
77	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.82603636
78	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.81999207
79	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.81356204
80	SA1_22415368_ChIP-Seq_MEFs_Mouse	0.81300482
81	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.79701015
82	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.78246885
83	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.75299072
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.75083047
85	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.74617252
86	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.74548636
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.74348001
88	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.73971812
89	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.72103646
90	DPY_21335234_ChIP-Seq_ESCs_Mouse	0.71559914
91	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.71293082
92	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.70193748
93	CBP_21632823_ChIP-Seq_H3396_Human	0.69886390
94	GF1_26923725_Chip-Seq_HPCs_Mouse	0.69751123
95	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.68832098
96	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.68513853
97	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.68393261
98	ZNF274_21170338_ChIP-Seq_K562_Hela	0.67947312
99	TP63_22573176_ChIP-Seq_HFKS_Human	0.67561652
100	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.66254598

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005084_abnormal_gallbladder_morpholo	8.27230453
2	MP0002877_abnormal_melanocyte_morpholog	7.65823174
3	MP0003252_abnormal_bile_duct	5.90814547
4	MP0004133_heterotaxia	5.00493992
5	MP0002928_abnormal_bile_duct	4.92855726
6	MP0000462_abnormal_digestive_system	4.50614752
7	MP0008995_early_reproductive_senescence	4.31422461
8	MP0003315_abnormal_perineum_morphology	3.98615347
9	MP0005408_hypopigmentation	3.53550980
10	MP0005187_abnormal_penis_morphology	3.10791501
11	MP0000631_abnormal_neuroendocrine_gland	2.88193276
12	MP0001270_distended_abdomen	2.72464021
13	MP0005220_abnormal_exocrine_pancreas	2.65913341
14	MP0001919_abnormal_reproductive_system	2.54397437
15	MP0002095_abnormal_skin_pigmentation	2.09799107
16	MP0002653_abnormal_ependyma_morphology	2.04879919
17	MP0002822_catalepsy	1.84224145
18	MP0008569_lethality_at_weaning	1.82909264
19	MP0006292_abnormal_olfactory_placode	1.64619119
20	MP0005381_digestive/alimentary_phenotyp	1.59587570
21	MP0008932_abnormal_embryonic_tissue	1.59569245
22	MP0005389_reproductive_system_phenotype	1.57567999
23	MP0000371_diluted_coat_color	1.50707382
24	MP0003942_abnormal_urinary_system	1.42435876
25	MP0005360_urolithiasis	1.31661913
26	MP0000647_abnormal_sebaceous_gland	1.25008500
27	MP0003136_yellow_coat_color	1.23313444
28	MP0003119_abnormal_digestive_system	1.23312349
29	MP0009703_decreased_birth_body	1.07391527
30	MP0004885_abnormal_endolymph	0.94400902
31	MP0008260_abnormal_autophagy	0.93157762
32	MP0003786_premature_aging	0.85144697
33	MP0002736_abnormal_nociception_after	0.82136977
34	MP0009672_abnormal_birth_weight	0.79668635
35	MP0005646_abnormal_pituitary_gland	0.77798067
36	MP0000955_abnormal_spinal_cord	0.72315461
37	MP0003878_abnormal_ear_physiology	0.70831484
38	MP0005377_hearing/vestibular/ear_phenot	0.70831484
39	MP0002735_abnormal_chemical_nociception	0.70224872
40	MP0004859_abnormal_synaptic_plasticity	0.70022886
41	MP0003880_abnormal_central_pattern	0.69873980
42	MP0003283_abnormal_digestive_organ	0.68942605
43	MP0001944_abnormal_pancreas_morphology	0.67050730
44	MP0009379_abnormal_foot_pigmentation	0.64724026
45	MP0003303_peritoneal_inflammation	0.64456337
46	MP0006276_abnormal_autonomic_nervous	0.61855910
47	MP0000490_abnormal_crypts_of	0.60572113
48	MP0001485_abnormal_pinna_reflex	0.60379691
49	MP0009745_abnormal_behavioral_response	0.59304983
50	MP0002160_abnormal_reproductive_system	0.56170553
51	MP0002572_abnormal_emotion/affect_behav	0.56043317
52	MP0005464_abnormal_platelet_physiology	0.53697377
53	MP0002938_white_spotting	0.53349296
54	MP0003279_aneurysm	0.52641164
55	MP0002075_abnormal_coat/hair_pigmentati	0.50971578
56	MP0002557_abnormal_social/conspecific_i	0.49505310
57	MP0002166_altered_tumor_susceptibility	0.48730263
58	MP0002277_abnormal_respiratory_mucosa	0.47832301
59	MP0001968_abnormal_touch/_nociception	0.47677218
60	MP0000566_synostosis	0.47441728
61	MP0002063_abnormal_learning/memory/cond	0.47168073
62	MP0000163_abnormal_cartilage_morphology	0.47090823
63	MP0003879_abnormal_hair_cell	0.46072903
64	MP0005670_abnormal_white_adipose	0.45382604
65	MP0003787_abnormal_imprinting	0.45291001
66	MP0002069_abnormal_eating/drinking_beha	0.45076878
67	MP0003936_abnormal_reproductive_system	0.43491038
68	MP0002006_tumorigenesis	0.42478078
69	MP0005085_abnormal_gallbladder_physiolo	0.42313064
70	MP0001663_abnormal_digestive_system	0.41866982
71	MP0005423_abnormal_somatic_nervous	0.41729785
72	MP0002102_abnormal_ear_morphology	0.41576361
73	MP0003984_embryonic_growth_retardation	0.41421906
74	MP0002136_abnormal_kidney_physiology	0.40954009
75	MP0002067_abnormal_sensory_capabilities	0.40848040
76	MP0002088_abnormal_embryonic_growth/wei	0.39427916
77	MP0004883_abnormal_blood_vessel	0.39144388
78	MP0001986_abnormal_taste_sensitivity	0.38371452
79	MP0003011_delayed_dark_adaptation	0.36950805
80	MP0000026_abnormal_inner_ear	0.36864357
81	MP0002837_dystrophic_cardiac_calcinosis	0.36604880
82	MP0003866_abnormal_defecation	0.36551218
83	MP0009384_cardiac_valve_regurgitation	0.36191802
84	MP0000049_abnormal_middle_ear	0.35641721
85	MP0002111_abnormal_tail_morphology	0.34588550
86	MP0002135_abnormal_kidney_morphology	0.34105782
87	MP0000534_abnormal_ureter_morphology	0.33971284
88	MP0002184_abnormal_innervation	0.33783363
89	MP0005551_abnormal_eye_electrophysiolog	0.33380557
90	MP0000627_abnormal_mammary_gland	0.32738515
91	MP0003690_abnormal_glial_cell	0.32284602
92	MP0000762_abnormal_tongue_morphology	0.31676583
93	MP0002697_abnormal_eye_size	0.31228294
94	MP0000579_abnormal_nail_morphology	0.30954856
95	MP0002882_abnormal_neuron_morphology	0.30337564
96	MP0000613_abnormal_salivary_gland	0.30295338
97	MP0004142_abnormal_muscle_tone	0.30039698
98	MP0002108_abnormal_muscle_morphology	0.29725774
99	MP0002066_abnormal_motor_capabilities/c	0.28842199
100	MP0005645_abnormal_hypothalamus_physiol	0.28310024

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal delayed hypersensitivity skin test (HP:0002963)	7.18979315
2	Neoplasm of the heart (HP:0100544)	6.95652715
3	Ependymoma (HP:0002888)	6.55118698
4	Pulmonary infiltrates (HP:0002113)	4.92849016
5	Generalized hypopigmentation of hair (HP:0011358)	4.87511538
6	Neoplasm of the lung (HP:0100526)	4.75841733
7	Lymphangioma (HP:0100764)	4.70797022
8	Astrocytoma (HP:0009592)	4.49982356
9	Abnormality of the astrocytes (HP:0100707)	4.49982356
10	Tracheomalacia (HP:0002779)	4.29240222
11	Neoplasm of the respiratory system (HP:0100606)	4.28729714
12	Persistence of primary teeth (HP:0006335)	4.17732786
13	Premature graying of hair (HP:0002216)	4.09394802
14	Visceral angiomatosis (HP:0100761)	3.86584590
15	Skin nodule (HP:0200036)	3.82897420
16	Bronchomalacia (HP:0002780)	3.80159451
17	Ocular albinism (HP:0001107)	3.73500296
18	Glioma (HP:0009733)	3.72222379
19	Hemiplegia (HP:0002301)	3.67763520
20	Agitation (HP:0000713)	3.62482641
21	Hypopigmentation of the fundus (HP:0007894)	3.60048649
22	Abnormal sex determination (HP:0012244)	3.59804396
23	Sex reversal (HP:0012245)	3.59804396
24	Ankle clonus (HP:0011448)	3.59581330
25	Hemangiomatosis (HP:0007461)	3.59105615
26	Iris hypopigmentation (HP:0007730)	3.33007860
27	Hamartoma of the eye (HP:0010568)	3.30799498
28	Progressive neurologic deterioration (HP:0002344)	3.28134870
29	Natal tooth (HP:0000695)	3.10842149
30	Death in childhood (HP:0003819)	3.09754464
31	Abnormality of the axillary hair (HP:0100134)	3.07912044
32	Abnormality of secondary sexual hair (HP:0009888)	3.07912044
33	Abnormality of T cell physiology (HP:0011840)	3.07129825
34	Infantile muscular hypotonia (HP:0008947)	2.99728919
35	Abnormality of alanine metabolism (HP:0010916)	2.83777752
36	Hyperalaninemia (HP:0003348)	2.83777752
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.83777752
38	Atelectasis (HP:0100750)	2.83230979
39	Hemoptysis (HP:0002105)	2.69542896
40	Synostosis involving the elbow (HP:0003938)	2.68059100
41	Humeroradial synostosis (HP:0003041)	2.68059100
42	Neoplasm of striated muscle (HP:0009728)	2.66440613
43	Increased serum ferritin (HP:0003281)	2.63718751
44	Congenital, generalized hypertrichosis (HP:0004540)	2.59560892
45	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.39450696
46	Elevated erythrocyte sedimentation rate (HP:0003565)	2.35981774
47	Abnormality of purine metabolism (HP:0004352)	2.32161543
48	Angiofibromas (HP:0010615)	2.27650546
49	Adenoma sebaceum (HP:0009720)	2.27650546
50	Maternal diabetes (HP:0009800)	2.19711643
51	Microglossia (HP:0000171)	2.14301665
52	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.13743570
53	Hypoplastic labia majora (HP:0000059)	2.09889557
54	Protruding tongue (HP:0010808)	2.09865601
55	Apathy (HP:0000741)	2.07673223
56	Abnormality of iron homeostasis (HP:0011031)	2.05974962
57	Constricted visual fields (HP:0001133)	2.03715473
58	Chest pain (HP:0100749)	2.02881201
59	Congenital sensorineural hearing impairment (HP:0008527)	2.02167473
60	Anteriorly placed anus (HP:0001545)	2.01249014
61	Alveolar cell carcinoma (HP:0006519)	12.7504341
62	Neoplasm of the tracheobronchial system (HP:0100552)	11.6158831
63	Gingivitis (HP:0000230)	1.99176256
64	Abnormality of the labia majora (HP:0012881)	1.95854764
65	Ectopia lentis (HP:0001083)	1.89128351
66	Overlapping toe (HP:0001845)	1.88782458
67	Thoracolumbar scoliosis (HP:0002944)	1.87723880
68	Tongue fasciculations (HP:0001308)	1.85235494
69	Abnormality of T cells (HP:0002843)	1.83662492
70	Hemiparesis (HP:0001269)	1.83347962
71	Meningitis (HP:0001287)	1.83163034
72	Diminished motivation (HP:0000745)	1.79420255
73	Abnormality of transition element cation homeostasis (HP:0011030)	1.77356713
74	Prominent occiput (HP:0000269)	1.77061557
75	Bone marrow hypocellularity (HP:0005528)	1.76016233
76	Stereotypic behavior (HP:0000733)	1.71981857
77	Short nail (HP:0001799)	1.71945534
78	Abnormality of the pericardium (HP:0001697)	1.70284845
79	Abnormality of nucleobase metabolism (HP:0010932)	1.69585984
80	Hypogonadotrophic hypogonadism (HP:0000044)	1.68831209
81	Slender long bone (HP:0003100)	1.65078422
82	Emphysema (HP:0002097)	1.63538309
83	Muscle fibrillation (HP:0010546)	1.61284824
84	Spontaneous hematomas (HP:0007420)	1.61203621
85	Precocious puberty (HP:0000826)	1.60568772
86	Broad ribs (HP:0000885)	1.59967636
87	Advanced eruption of teeth (HP:0006288)	1.55980077
88	Restlessness (HP:0000711)	1.55680250
89	Biconcave vertebral bodies (HP:0004586)	1.55477770
90	Nasolacrimal duct obstruction (HP:0000579)	1.55379888
91	Annular pancreas (HP:0001734)	1.55231502
92	Restrictive lung disease (HP:0002091)	1.54631796
93	Woolly hair (HP:0002224)	1.49515069
94	Hamartoma (HP:0010566)	1.49164522
95	Abnormal respiratory epithelium morphology (HP:0012253)	1.48259800
96	Abnormal respiratory motile cilium morphology (HP:0005938)	1.48259800
97	White forelock (HP:0002211)	1.46244080
98	Reduced subcutaneous adipose tissue (HP:0003758)	1.44362127
99	Esophageal varix (HP:0002040)	1.43705686
100	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.43704722

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAF1	9.73631223
2	STK38L	5.70431515
3	STK24	5.62414669
4	PRKCI	4.73776609
5	MAP3K5	3.92531298
6	CAMK1D	3.34368197
7	BLK	3.18091791
8	JAK3	2.81912253
9	CAMK1G	2.37512771
10	ZAK	2.01046977
11	ITK	1.70056859
12	MATK	1.69959789
13	TEC	1.59896355
14	CAMK1	1.37152953
15	STK3	1.28773610
16	CAMK4	1.24948204
17	PINK1	1.17529561
18	ERBB2	1.04494606
19	PRKD3	0.99954189
20	RPS6KA2	0.91972196
21	NTRK2	0.82882940
22	EPHB2	0.79350558
23	MAPK15	0.73028946
24	MAP4K2	0.72745973
25	INSRR	0.69204261
26	CSK	0.65890895
27	ATR	0.65140871
28	CDC7	0.64510959
29	CCNB1	0.64096025
30	OBSCN	0.63569821
31	RPS6KA6	0.61962555
32	IKBKB	0.61873934
33	RPS6KL1	0.61805736
34	RPS6KC1	0.61805736
35	BTK	0.60888147
36	MAP3K3	0.56125997
37	RPS6KB2	0.55524575
38	TIE1	0.55471788
39	SGK3	0.51752037
40	AURKA	0.50335101
41	GRK1	0.48768455
42	MAP2K7	0.48449139
43	TLK1	0.47477590
44	ACVR1B	0.45538268
45	EPHA4	0.44876896
46	MAP3K1	0.44866657
47	SYK	0.43843124
48	MUSK	0.43707093
49	MAP3K4	0.42702042
50	WNK3	0.40862823
51	PIK3CA	0.38289867
52	ROCK2	0.36654300
53	PRKAA1	0.36396060
54	PRKACA	0.36357313
55	CAMK2A	0.35224655
56	AKT1	0.34976918
57	WNK4	0.34276846
58	MAPKAPK5	0.33742437
59	PTK6	0.31883066
60	ADRBK2	0.31058008
61	MAP3K10	0.30012991
62	TTK	0.29173387
63	PRKCZ	0.29092918
64	GRK7	0.28721559
65	RPS6KA1	0.28302730
66	ATM	0.27989818
67	CSNK2A1	0.25169682
68	PHKG2	0.23880534
69	PHKG1	0.23880534
70	CDK3	0.21183629
71	ADRBK1	0.21161554
72	MAPK7	0.20800276
73	MAPKAPK2	0.20778510
74	UHMK1	0.19412711
75	NTRK3	0.19360687
76	TXK	0.19008088
77	CSNK1A1	0.16653651
78	GRK5	0.16445483
79	LMTK2	0.16377615
80	MAPK8	0.15538886
81	KIT	0.15397624
82	MOS	0.15028061
83	MAP2K4	0.15013531
84	MAP3K11	0.14219939
85	MAPK13	0.13840876
86	CDK9	0.13699488
87	CAMK2G	0.13690770
88	PRKCD	0.13356684
89	ERBB4	0.13024246
90	PLK4	0.12739081
91	PRKACG	0.12475114
92	INSR	0.12473688
93	GSK3B	0.12413076
94	MST1R	0.12387425
95	CDK2	0.12369909
96	SGK223	0.12319890
97	SGK494	0.12319890
98	PRKCE	0.12031912
99	PRKCG	0.11912322
100	MAPK1	0.11452218

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur metabolism_Homo sapiens_hsa00920	5.70416618
2	Hedgehog signaling pathway_Homo sapiens_hsa04340	4.02544470
3	Basal cell carcinoma_Homo sapiens_hsa05217	3.99187425
4	Fructose and mannose metabolism_Homo sapiens_hsa00051	3.71142496
5	Linoleic acid metabolism_Homo sapiens_hsa00591	3.50914599
6	Homologous recombination_Homo sapiens_hsa03440	2.98376869
7	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.81021966
8	Galactose metabolism_Homo sapiens_hsa00052	2.21450360
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.06459116
10	Fanconi anemia pathway_Homo sapiens_hsa03460	1.76614886
11	Regulation of autophagy_Homo sapiens_hsa04140	1.72265593
12	Nicotine addiction_Homo sapiens_hsa05033	1.66843091
13	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.64441678
14	AMPK signaling pathway_Homo sapiens_hsa04152	1.60515479
15	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.59522590
16	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.46978371
17	Serotonergic synapse_Homo sapiens_hsa04726	1.43130190
18	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.41809196
19	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.37848684
20	Complement and coagulation cascades_Homo sapiens_hsa04610	1.36338469
21	Notch signaling pathway_Homo sapiens_hsa04330	1.35198451
22	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.34532463
23	Taste transduction_Homo sapiens_hsa04742	1.26050078
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.25847572
25	GABAergic synapse_Homo sapiens_hsa04727	1.22206435
26	Morphine addiction_Homo sapiens_hsa05032	1.21503869
27	Retinol metabolism_Homo sapiens_hsa00830	1.21402608
28	Ribosome_Homo sapiens_hsa03010	1.19612592
29	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.19605303
30	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.18343029
31	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.16201939
32	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.13116337
33	Arginine biosynthesis_Homo sapiens_hsa00220	1.12389739
34	Olfactory transduction_Homo sapiens_hsa04740	1.11908619
35	cAMP signaling pathway_Homo sapiens_hsa04024	1.06497185
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.99810420
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.96557519
38	Caffeine metabolism_Homo sapiens_hsa00232	0.95944284
39	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.95833449
40	Nitrogen metabolism_Homo sapiens_hsa00910	0.94103708
41	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.91734016
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88106731
43	Asthma_Homo sapiens_hsa05310	0.87604126
44	mTOR signaling pathway_Homo sapiens_hsa04150	0.84997252
45	Glutamatergic synapse_Homo sapiens_hsa04724	0.84817474
46	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.84617271
47	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.84142432
48	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.82713296
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81211597
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.79708405
51	Circadian entrainment_Homo sapiens_hsa04713	0.74996481
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74502245
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69422240
54	Bile secretion_Homo sapiens_hsa04976	0.68809913
55	Long-term depression_Homo sapiens_hsa04730	0.68448040
56	Sulfur relay system_Homo sapiens_hsa04122	0.64737513
57	Phototransduction_Homo sapiens_hsa04744	0.63838684
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.60192521
59	Herpes simplex infection_Homo sapiens_hsa05168	0.58273443
60	Oxidative phosphorylation_Homo sapiens_hsa00190	0.57148741
61	Parkinsons disease_Homo sapiens_hsa05012	0.57036155
62	Tyrosine metabolism_Homo sapiens_hsa00350	0.56771516
63	Basal transcription factors_Homo sapiens_hsa03022	0.56719957
64	Graft-versus-host disease_Homo sapiens_hsa05332	0.56666022
65	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.56112266
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55613047
67	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54326351
68	Salivary secretion_Homo sapiens_hsa04970	0.53447875
69	Allograft rejection_Homo sapiens_hsa05330	0.49170612
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48147633
71	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.47959725
72	Type I diabetes mellitus_Homo sapiens_hsa04940	0.47431538
73	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.46932386
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.46436763
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46307499
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.44164101
77	Insulin secretion_Homo sapiens_hsa04911	0.43746193
78	Alcoholism_Homo sapiens_hsa05034	0.43234389
79	One carbon pool by folate_Homo sapiens_hsa00670	0.42566427
80	Melanogenesis_Homo sapiens_hsa04916	0.41735240
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41131702
82	p53 signaling pathway_Homo sapiens_hsa04115	0.39838065
83	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38008787
84	Protein digestion and absorption_Homo sapiens_hsa04974	0.36547486
85	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.34289611
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.33315084
87	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.33256804
88	Cholinergic synapse_Homo sapiens_hsa04725	0.33175585
89	ECM-receptor interaction_Homo sapiens_hsa04512	0.32881916
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.30460989
91	Phenylalanine metabolism_Homo sapiens_hsa00360	0.29272514
92	MAPK signaling pathway_Homo sapiens_hsa04010	0.29176751
93	Huntingtons disease_Homo sapiens_hsa05016	0.28867808
94	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.27432101
95	MicroRNAs in cancer_Homo sapiens_hsa05206	0.27293827
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.25275532
97	Malaria_Homo sapiens_hsa05144	0.25237575
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.24541611
99	Pathways in cancer_Homo sapiens_hsa05200	0.23839454
100	Gastric acid secretion_Homo sapiens_hsa04971	0.23418420

HNRNPA3P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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