HNRNPA3P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.15412579
2viral transcription (GO:0019083)6.19232330
3translational termination (GO:0006415)5.99630214
4ribosomal small subunit biogenesis (GO:0042274)5.91582209
5chaperone-mediated protein transport (GO:0072321)5.64615009
6positive regulation of glycoprotein biosynthetic process (GO:0010560)5.64376604
7spermatid nucleus differentiation (GO:0007289)5.54418471
8establishment of protein localization to mitochondrial membrane (GO:0090151)5.52457437
9transcription from RNA polymerase I promoter (GO:0006360)5.48968605
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.23907454
11ATP synthesis coupled proton transport (GO:0015986)5.17497146
12energy coupled proton transport, down electrochemical gradient (GO:0015985)5.17497146
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.11136962
14cotranslational protein targeting to membrane (GO:0006613)5.10290880
15protein targeting to ER (GO:0045047)5.03347978
16regulation of protein glycosylation (GO:0060049)4.83673891
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.81742659
18positive regulation of glycoprotein metabolic process (GO:1903020)4.77361241
19protein localization to endoplasmic reticulum (GO:0070972)4.71915622
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.68083502
21translational elongation (GO:0006414)4.64479939
22cellular protein complex disassembly (GO:0043624)4.47104013
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.39389797
24cell proliferation in forebrain (GO:0021846)4.31038503
25protein polyglutamylation (GO:0018095)4.28145578
26maturation of SSU-rRNA (GO:0030490)4.25018350
27viral life cycle (GO:0019058)4.24693121
28translational initiation (GO:0006413)4.20681164
29acrosome assembly (GO:0001675)4.11877186
30resolution of meiotic recombination intermediates (GO:0000712)4.07582740
31chromatin remodeling at centromere (GO:0031055)3.97819022
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.97504700
33NADH dehydrogenase complex assembly (GO:0010257)3.97504700
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.97504700
35respiratory electron transport chain (GO:0022904)3.95304437
36electron transport chain (GO:0022900)3.93488845
37protein complex biogenesis (GO:0070271)3.91168222
38arachidonic acid secretion (GO:0050482)3.90667832
39icosanoid secretion (GO:0032309)3.90667832
40protein complex disassembly (GO:0043241)3.87840892
41CENP-A containing nucleosome assembly (GO:0034080)3.84532570
42activated T cell proliferation (GO:0050798)3.76315914
43mitochondrial respiratory chain complex assembly (GO:0033108)3.71449007
44protein-cofactor linkage (GO:0018065)3.68843925
45nonmotile primary cilium assembly (GO:0035058)3.64595162
46diacylglycerol metabolic process (GO:0046339)3.63768630
47macromolecular complex disassembly (GO:0032984)3.61400272
48maturation of 5.8S rRNA (GO:0000460)3.51528464
49translation (GO:0006412)3.47898842
502-deoxyribonucleotide biosynthetic process (GO:0009265)3.46111744
51deoxyribose phosphate biosynthetic process (GO:0046385)3.46111744
52protein targeting to membrane (GO:0006612)3.45141566
53formation of translation preinitiation complex (GO:0001731)3.37887743
54pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.37787658
55cell fate commitment involved in formation of primary germ layer (GO:0060795)3.30941082
56intracellular protein transmembrane import (GO:0044743)3.26161091
57termination of RNA polymerase I transcription (GO:0006363)3.25732734
58DNA topological change (GO:0006265)3.21629973
59ncRNA 3-end processing (GO:0043628)3.21133462
60histone exchange (GO:0043486)3.13552847
61DNA replication-independent nucleosome assembly (GO:0006336)3.13227284
62DNA replication-independent nucleosome organization (GO:0034724)3.13227284
63pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.09230378
64protein heterotetramerization (GO:0051290)3.08363274
65inner mitochondrial membrane organization (GO:0007007)3.08274420
66ubiquinone biosynthetic process (GO:0006744)3.07176280
67negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.06295442
68histone mRNA metabolic process (GO:0008334)3.05408168
69transcription elongation from RNA polymerase I promoter (GO:0006362)3.04408412
70establishment of tissue polarity (GO:0007164)3.04126496
71establishment of planar polarity (GO:0001736)3.04126496
72nuclear-transcribed mRNA catabolic process (GO:0000956)3.02897759
73tongue development (GO:0043586)3.01341411
74protein neddylation (GO:0045116)2.98614510
75icosanoid transport (GO:0071715)2.98481384
76fatty acid derivative transport (GO:1901571)2.98481384
77pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.97174592
78kinetochore organization (GO:0051383)2.97089096
79histone H2B ubiquitination (GO:0033523)2.93823896
80negative regulation of execution phase of apoptosis (GO:1900118)2.90210160
81pituitary gland development (GO:0021983)2.89491782
82deoxyribonucleotide biosynthetic process (GO:0009263)2.85412824
83proteasome assembly (GO:0043248)2.85373640
84mRNA catabolic process (GO:0006402)2.83287661
85kinetochore assembly (GO:0051382)2.82035507
86sister chromatid segregation (GO:0000819)2.81093046
87response to misfolded protein (GO:0051788)2.76720352
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75462084
89regulation of cellular respiration (GO:0043457)2.74685019
90ubiquinone metabolic process (GO:0006743)2.73296407
91deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.73271494
92response to histamine (GO:0034776)2.73051668
93rRNA processing (GO:0006364)2.69591613
94cellular component biogenesis (GO:0044085)2.68261459
95heterotypic cell-cell adhesion (GO:0034113)2.67081965
96regulation of mitochondrial translation (GO:0070129)2.66748233
97DNA-templated transcription, termination (GO:0006353)2.65914134
98transcription initiation from RNA polymerase I promoter (GO:0006361)2.65650094
99termination of RNA polymerase III transcription (GO:0006386)2.64349418
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.64349418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.08977025
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.37690485
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.74914132
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.54507723
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.53177855
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.16570718
7EZH2_22144423_ChIP-Seq_EOC_Human3.14962362
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.05790488
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79487863
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.70801436
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48526302
12YY1_21170310_ChIP-Seq_MESCs_Mouse2.39104922
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.30274111
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21072309
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12541803
16ELK1_19687146_ChIP-ChIP_HELA_Human2.10133935
17SOX2_18555785_ChIP-Seq_MESCs_Mouse1.92738743
18FUS_26573619_Chip-Seq_HEK293_Human1.88964426
19E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87159952
20MYC_18940864_ChIP-ChIP_HL60_Human1.86909099
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86601409
22TTF2_22483619_ChIP-Seq_HELA_Human1.78138813
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.77833480
24VDR_23849224_ChIP-Seq_CD4+_Human1.73883594
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72947658
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.72432480
27IRF1_19129219_ChIP-ChIP_H3396_Human1.68583937
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62896533
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62305376
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58877570
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.57591068
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.57506443
33FOXP3_21729870_ChIP-Seq_TREG_Human1.54036094
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51442488
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47296258
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45246833
37EWS_26573619_Chip-Seq_HEK293_Human1.43751688
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41893544
39IGF1R_20145208_ChIP-Seq_DFB_Human1.39703602
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36599403
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34124505
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33407778
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32554262
44VDR_22108803_ChIP-Seq_LS180_Human1.32268229
45SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.28067969
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.24117508
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21061259
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21029108
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19778287
50XRN2_22483619_ChIP-Seq_HELA_Human1.16672959
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15652185
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.15137542
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.13105390
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10178083
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.09246783
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06965752
57CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05961465
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05547302
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01933838
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.01909954
61P300_19829295_ChIP-Seq_ESCs_Human1.01557715
62SOX2_19829295_ChIP-Seq_ESCs_Human0.97076755
63NANOG_19829295_ChIP-Seq_ESCs_Human0.97076755
64GATA3_21867929_ChIP-Seq_TH1_Mouse0.97053449
65AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96994850
66BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96457517
67SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95757993
68NFE2_27457419_Chip-Seq_LIVER_Mouse0.95644052
69E2F7_22180533_ChIP-Seq_HELA_Human0.95467566
70ELK1_22589737_ChIP-Seq_MCF10A_Human0.95246213
71POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95041709
72CBX2_27304074_Chip-Seq_ESCs_Mouse0.94493112
73E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94130905
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93969388
75CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92938085
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91202705
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90902418
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89950100
79SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89794489
80RNF2_27304074_Chip-Seq_NSC_Mouse0.88856195
81ZNF274_21170338_ChIP-Seq_K562_Hela0.87794607
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87733164
83SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86079226
84CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85408875
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.85234076
86TP53_22573176_ChIP-Seq_HFKS_Human0.84325401
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83501423
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80929608
89SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80730016
90EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79634703
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.79130906
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78869899
93TAF15_26573619_Chip-Seq_HEK293_Human0.78156529
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.76288291
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.76288291
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.76288291
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76208062
98AR_20517297_ChIP-Seq_VCAP_Human0.74148721
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73938239
100TAF2_19829295_ChIP-Seq_ESCs_Human0.73654940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode7.39141635
2MP0009379_abnormal_foot_pigmentation4.15547925
3MP0001529_abnormal_vocalization3.40832651
4MP0001293_anophthalmia3.35620933
5MP0004885_abnormal_endolymph3.00091169
6MP0003878_abnormal_ear_physiology2.91036380
7MP0005377_hearing/vestibular/ear_phenot2.91036380
8MP0004142_abnormal_muscle_tone2.33855163
9MP0002933_joint_inflammation2.31032963
10MP0002277_abnormal_respiratory_mucosa2.27160126
11MP0003136_yellow_coat_color2.19362544
12MP0003567_abnormal_fetal_cardiomyocyte2.10841469
13MP0000566_synostosis1.94927970
14MP0002653_abnormal_ependyma_morphology1.90889825
15MP0003315_abnormal_perineum_morphology1.89588848
16MP0006072_abnormal_retinal_apoptosis1.85530807
17MP0001905_abnormal_dopamine_level1.84305903
18MP0003937_abnormal_limbs/digits/tail_de1.78371852
19MP0002736_abnormal_nociception_after1.77104651
20MP0003646_muscle_fatigue1.70631301
21MP0005253_abnormal_eye_physiology1.70057099
22MP0008789_abnormal_olfactory_epithelium1.69693112
23MP0000778_abnormal_nervous_system1.64608762
24MP0001485_abnormal_pinna_reflex1.60794903
25MP0000372_irregular_coat_pigmentation1.59603545
26MP0001851_eye_inflammation1.57278518
27MP0003011_delayed_dark_adaptation1.54001520
28MP0003693_abnormal_embryo_hatching1.43611044
29MP0003938_abnormal_ear_development1.42446146
30MP0000049_abnormal_middle_ear1.36707262
31MP0010094_abnormal_chromosome_stability1.33341391
32MP0004957_abnormal_blastocyst_morpholog1.32045516
33MP0003195_calcinosis1.31500075
34MP0008875_abnormal_xenobiotic_pharmacok1.30095415
35MP0005391_vision/eye_phenotype1.27162082
36MP0006035_abnormal_mitochondrial_morpho1.26051048
37MP0008995_early_reproductive_senescence1.26032024
38MP0002822_catalepsy1.23331603
39MP0005187_abnormal_penis_morphology1.22728134
40MP0008877_abnormal_DNA_methylation1.21850391
41MP0001440_abnormal_grooming_behavior1.20187197
42MP0001727_abnormal_embryo_implantation1.19193469
43MP0000631_abnormal_neuroendocrine_gland1.18511800
44MP0005499_abnormal_olfactory_system1.16503278
45MP0005394_taste/olfaction_phenotype1.16503278
46MP0005197_abnormal_uvea_morphology1.16231634
47MP0002160_abnormal_reproductive_system1.10838860
48MP0001968_abnormal_touch/_nociception1.10204016
49MP0005195_abnormal_posterior_eye1.07952565
50MP0001486_abnormal_startle_reflex1.07156696
51MP0000579_abnormal_nail_morphology1.04225976
52MP0002234_abnormal_pharynx_morphology1.04065296
53MP0002697_abnormal_eye_size1.03307107
54MP0002210_abnormal_sex_determination0.98442132
55MP0010386_abnormal_urinary_bladder0.96490779
56MP0001286_abnormal_eye_development0.95614389
57MP0003942_abnormal_urinary_system0.94602642
58MP0000026_abnormal_inner_ear0.94388454
59MP0005595_abnormal_vascular_smooth0.93477155
60MP0003755_abnormal_palate_morphology0.91919631
61MP0003880_abnormal_central_pattern0.91687706
62MP0003718_maternal_effect0.89396579
63MP0005386_behavior/neurological_phenoty0.88048733
64MP0004924_abnormal_behavior0.88048733
65MP0009745_abnormal_behavioral_response0.87241571
66MP0009046_muscle_twitch0.86852395
67MP0004133_heterotaxia0.86479684
68MP0003121_genomic_imprinting0.85728109
69MP0001191_abnormal_skin_condition0.85524286
70MP0002876_abnormal_thyroid_physiology0.84370112
71MP0003941_abnormal_skin_development0.84158145
72MP0000462_abnormal_digestive_system0.82965197
73MP0002557_abnormal_social/conspecific_i0.82508971
74MP0003122_maternal_imprinting0.82298079
75MP0010030_abnormal_orbit_morphology0.78957979
76MP0005389_reproductive_system_phenotype0.78354440
77MP0004947_skin_inflammation0.77110565
78MP0008058_abnormal_DNA_repair0.76919089
79MP0002938_white_spotting0.75454909
80MP0002752_abnormal_somatic_nervous0.75178866
81MP0002572_abnormal_emotion/affect_behav0.75114410
82MP0001145_abnormal_male_reproductive0.73794255
83MP0006082_CNS_inflammation0.73349919
84MP0000653_abnormal_sex_gland0.73071753
85MP0001919_abnormal_reproductive_system0.72351058
86MP0001963_abnormal_hearing_physiology0.71786764
87MP0000428_abnormal_craniofacial_morphol0.71307908
88MP0002734_abnormal_mechanical_nocicepti0.71116759
89MP0001929_abnormal_gametogenesis0.70894216
90MP0000230_abnormal_systemic_arterial0.70124130
91MP0003137_abnormal_impulse_conducting0.69640897
92MP0005193_abnormal_anterior_eye0.69408830
93MP0008872_abnormal_physiological_respon0.69202557
94MP0002092_abnormal_eye_morphology0.68581148
95MP0002233_abnormal_nose_morphology0.66701208
96MP0005551_abnormal_eye_electrophysiolog0.66666439
97MP0009384_cardiac_valve_regurgitation0.66451436
98MP0006036_abnormal_mitochondrial_physio0.64695023
99MP0003861_abnormal_nervous_system0.63991789
100MP0000955_abnormal_spinal_cord0.62074767

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)5.54546314
2Aplasia/Hypoplasia of the sacrum (HP:0008517)5.20743876
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.91784901
4Chronic bronchitis (HP:0004469)4.50492013
5Maternal diabetes (HP:0009800)4.47084607
63-Methylglutaconic aciduria (HP:0003535)4.22363603
7Sparse scalp hair (HP:0002209)4.05621615
8Septo-optic dysplasia (HP:0100842)4.02932674
9Hypoproteinemia (HP:0003075)3.85944636
10Panhypogammaglobulinemia (HP:0003139)3.84571863
11Acute necrotizing encephalopathy (HP:0006965)3.81118042
12Periodontitis (HP:0000704)3.72011966
13Eosinophilia (HP:0001880)3.71271313
14B lymphocytopenia (HP:0010976)3.53113065
15Leukocytosis (HP:0001974)3.46554675
16Nasal speech (HP:0001611)3.45097607
17Acute encephalopathy (HP:0006846)3.44909789
18Abnormal mitochondria in muscle tissue (HP:0008316)3.37415769
19Abnormality of B cell number (HP:0010975)3.32952245
20Abnormality of the intervertebral disk (HP:0005108)3.26260283
21Abnormal respiratory motile cilium physiology (HP:0012261)3.15211229
22Macrocytic anemia (HP:0001972)3.12294627
23Colon cancer (HP:0003003)3.08268421
24Abnormal number of incisors (HP:0011064)3.07862448
25Mitochondrial inheritance (HP:0001427)2.98411284
26Increased hepatocellular lipid droplets (HP:0006565)2.94412299
27Progressive macrocephaly (HP:0004481)2.92115997
28Submucous cleft hard palate (HP:0000176)2.91268541
29Recurrent abscess formation (HP:0002722)2.82645851
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.79122672
31Absent/shortened dynein arms (HP:0200106)2.79122672
32Rhinitis (HP:0012384)2.75444697
33Abnormality of cells of the erythroid lineage (HP:0012130)2.73580456
34Pallor (HP:0000980)2.71003152
35Absent septum pellucidum (HP:0001331)2.69830935
36Lipid accumulation in hepatocytes (HP:0006561)2.69822904
37Reticulocytopenia (HP:0001896)2.67688919
38Hypoplasia of the thymus (HP:0000778)2.66870076
39Methylmalonic acidemia (HP:0002912)2.66712372
40Hepatocellular necrosis (HP:0001404)2.64722442
41Deep philtrum (HP:0002002)2.63227042
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.59722323
43Rib fusion (HP:0000902)2.58286267
44Abnormal number of erythroid precursors (HP:0012131)2.54763810
45Granulocytopenia (HP:0001913)2.54496076
46Increased CSF lactate (HP:0002490)2.52609746
47Congenital, generalized hypertrichosis (HP:0004540)2.48980349
48Severe combined immunodeficiency (HP:0004430)2.48643608
49Abnormality of the septum pellucidum (HP:0007375)2.46042626
50Abnormality of eosinophils (HP:0001879)2.43136429
51Increased IgM level (HP:0003496)2.39697203
52Autoimmune thrombocytopenia (HP:0001973)2.36914839
53Hyperglycinemia (HP:0002154)2.35420133
54Optic disc pallor (HP:0000543)2.30830106
55Absent hand (HP:0004050)2.29334112
5611 pairs of ribs (HP:0000878)2.23398236
57Increased serum lactate (HP:0002151)2.17188065
58Hepatic necrosis (HP:0002605)2.16598796
59Thyroiditis (HP:0100646)2.15589676
60Optic nerve hypoplasia (HP:0000609)2.14005343
61Cerebral edema (HP:0002181)2.11459272
62Oral leukoplakia (HP:0002745)2.11226341
63Esophageal atresia (HP:0002032)2.08890534
64Decreased central vision (HP:0007663)2.06543011
65Methylmalonic aciduria (HP:0012120)2.06038064
66Renal Fanconi syndrome (HP:0001994)2.05351667
67Exertional dyspnea (HP:0002875)2.04837297
68Combined immunodeficiency (HP:0005387)2.03489426
69Bony spicule pigmentary retinopathy (HP:0007737)2.02130032
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00702073
71Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00702073
72Delayed CNS myelination (HP:0002188)1.99871600
73Abnormality of the nasal septum (HP:0000419)1.98332652
74Increased intramyocellular lipid droplets (HP:0012240)1.97621426
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96262074
76Achilles tendon contracture (HP:0001771)1.95344122
77Respiratory difficulties (HP:0002880)1.94254857
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93924869
79Erythroderma (HP:0001019)1.92730928
80Abnormal ciliary motility (HP:0012262)1.91529439
81Abnormality of T cell number (HP:0011839)1.89496335
82Aplastic anemia (HP:0001915)1.88656145
83Cerebellar dysplasia (HP:0007033)1.87729551
84Lactic acidosis (HP:0003128)1.83956266
85Abnormal hemoglobin (HP:0011902)1.83213632
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82753075
87Anencephaly (HP:0002323)1.82682922
88Hypochromic anemia (HP:0001931)1.79165051
89Gingivitis (HP:0000230)1.77960553
90Autoimmune hemolytic anemia (HP:0001890)1.76008985
91Myelomeningocele (HP:0002475)1.74055928
92Nephronophthisis (HP:0000090)1.73092124
93Holoprosencephaly (HP:0001360)1.72365655
94Pendular nystagmus (HP:0012043)1.71412612
95Bronchitis (HP:0012387)1.70119873
96Abnormality of the Achilles tendon (HP:0005109)1.69985973
97Abnormal respiratory motile cilium morphology (HP:0005938)1.69147460
98Abnormal respiratory epithelium morphology (HP:0012253)1.69147460
99Respiratory distress (HP:0002098)1.67813648
100Bronchiectasis (HP:0002110)1.65443311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK6.25403272
2ZAK4.28654496
3PRKCH4.06676314
4SRPK13.94437372
5CDC73.34164815
6VRK22.51009251
7TXK1.90434418
8VRK11.89436078
9BRSK21.87795265
10TYRO31.82117013
11PLK31.74431392
12DYRK21.62687997
13PLK11.59886668
14DYRK31.54856109
15BUB11.47183023
16STK391.41376491
17RPS6KA41.39020921
18FES1.36792768
19WNK41.33279871
20TLK11.31513380
21TTK1.27143982
22WEE11.21752018
23PAK31.17941582
24BRSK11.17184794
25MAP4K11.14913111
26NLK1.12002669
27EPHA41.10363845
28NME11.07257726
29DAPK11.07224438
30CASK1.06911747
31AKT31.06739892
32ADRBK21.05442872
33ALK1.05142493
34AURKB1.03592774
35EPHB20.98275718
36PKN10.98236369
37NTRK30.97321168
38NEK20.94703770
39CSNK1E0.92511646
40WNK30.91280226
41ADRBK10.89870692
42AURKA0.89580762
43TNIK0.86791949
44MKNK10.85696455
45MAP3K110.84691170
46LATS10.83709222
47MKNK20.82130656
48ATR0.81109467
49NUAK10.79975550
50CHEK20.79427872
51MAPK150.77336957
52INSRR0.76483179
53CSK0.76052756
54MAP3K20.73299192
55TIE10.73275918
56BCR0.72911853
57MAP2K60.72412901
58PRKCG0.68261501
59RPS6KA50.64239945
60CSNK2A20.64189065
61NEK10.63137724
62MAPK130.62428920
63MARK30.62309175
64PLK40.62093141
65PNCK0.61599853
66MINK10.60566869
67RPS6KA60.60026978
68NME20.58364981
69PASK0.57648946
70CSNK2A10.55476289
71TAF10.53429192
72PRKG10.53178722
73RPS6KC10.51125296
74RPS6KL10.51125296
75CAMK2A0.50644202
76RPS6KA20.50006034
77ATM0.49940127
78MAP3K80.49293996
79CSNK1A10.49241528
80SGK2230.48473424
81SGK4940.48473424
82GRK10.47759638
83CAMK2B0.46368513
84SGK20.44699647
85PRKCQ0.44623368
86ICK0.44531940
87PRKACA0.44167678
88PRKCD0.43925595
89LCK0.43847705
90DYRK1A0.43334938
91STK40.42448558
92CAMK10.41686013
93CDK30.41454765
94EPHA30.40539892
95PRKCB0.40512862
96MAP3K60.40374984
97STK160.36202943
98FGFR10.35925366
99STK38L0.35635010
100EIF2AK30.35149124

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030205.82372459
2Ribosome_Homo sapiens_hsa030105.30841279
3Oxidative phosphorylation_Homo sapiens_hsa001903.77919689
4Parkinsons disease_Homo sapiens_hsa050123.53692315
5Proteasome_Homo sapiens_hsa030503.10977074
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.89014447
7Huntingtons disease_Homo sapiens_hsa050162.53830863
8Spliceosome_Homo sapiens_hsa030402.49325419
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.34004316
10Alzheimers disease_Homo sapiens_hsa050102.22161297
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.13844826
12Pyrimidine metabolism_Homo sapiens_hsa002402.04214800
13Homologous recombination_Homo sapiens_hsa034402.01052704
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92370442
15Protein export_Homo sapiens_hsa030601.91343543
16Mismatch repair_Homo sapiens_hsa034301.89258662
17Cardiac muscle contraction_Homo sapiens_hsa042601.70696249
18Non-homologous end-joining_Homo sapiens_hsa034501.58736947
19Linoleic acid metabolism_Homo sapiens_hsa005911.57416888
20Purine metabolism_Homo sapiens_hsa002301.55720072
21DNA replication_Homo sapiens_hsa030301.55399962
22Basal transcription factors_Homo sapiens_hsa030221.53989850
23Nucleotide excision repair_Homo sapiens_hsa034201.46095966
24RNA transport_Homo sapiens_hsa030131.34749929
25Malaria_Homo sapiens_hsa051441.33504918
26Nitrogen metabolism_Homo sapiens_hsa009101.30820956
27Primary immunodeficiency_Homo sapiens_hsa053401.26979520
28RNA degradation_Homo sapiens_hsa030181.26314446
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25610656
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18055887
31Graft-versus-host disease_Homo sapiens_hsa053321.10073150
32Fanconi anemia pathway_Homo sapiens_hsa034601.03230947
33Glycerolipid metabolism_Homo sapiens_hsa005611.02609061
34Viral myocarditis_Homo sapiens_hsa054161.02014765
35Ether lipid metabolism_Homo sapiens_hsa005650.97595298
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95498993
37Legionellosis_Homo sapiens_hsa051340.93111971
38Type I diabetes mellitus_Homo sapiens_hsa049400.92789293
39Autoimmune thyroid disease_Homo sapiens_hsa053200.90037027
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89409275
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83077846
42Allograft rejection_Homo sapiens_hsa053300.82391329
43Olfactory transduction_Homo sapiens_hsa047400.81303638
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80317416
45Staphylococcus aureus infection_Homo sapiens_hsa051500.78249739
46Hippo signaling pathway_Homo sapiens_hsa043900.75432756
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.73923118
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72144603
49Basal cell carcinoma_Homo sapiens_hsa052170.72019330
50Chemical carcinogenesis_Homo sapiens_hsa052040.71359097
51Glutathione metabolism_Homo sapiens_hsa004800.70838612
52Pyruvate metabolism_Homo sapiens_hsa006200.69936520
53Fat digestion and absorption_Homo sapiens_hsa049750.64099501
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62688383
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61981219
56Phototransduction_Homo sapiens_hsa047440.56732775
57Arachidonic acid metabolism_Homo sapiens_hsa005900.54425202
58Taste transduction_Homo sapiens_hsa047420.54041298
59Propanoate metabolism_Homo sapiens_hsa006400.51178098
60Metabolic pathways_Homo sapiens_hsa011000.50065119
61Nicotine addiction_Homo sapiens_hsa050330.48799188
62Base excision repair_Homo sapiens_hsa034100.47992776
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47456410
64Rheumatoid arthritis_Homo sapiens_hsa053230.47091909
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46156141
66Cell cycle_Homo sapiens_hsa041100.45728442
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44838893
68Hedgehog signaling pathway_Homo sapiens_hsa043400.43956528
69Pertussis_Homo sapiens_hsa051330.42542399
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40813888
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39644781
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38621695
73Leishmaniasis_Homo sapiens_hsa051400.38221513
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.37255960
75Systemic lupus erythematosus_Homo sapiens_hsa053220.36801345
76Oocyte meiosis_Homo sapiens_hsa041140.36609038
77Selenocompound metabolism_Homo sapiens_hsa004500.34678533
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34127809
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32188670
80Wnt signaling pathway_Homo sapiens_hsa043100.32051887
81mRNA surveillance pathway_Homo sapiens_hsa030150.28873406
82Serotonergic synapse_Homo sapiens_hsa047260.28264038
83Fatty acid elongation_Homo sapiens_hsa000620.28210044
84Epstein-Barr virus infection_Homo sapiens_hsa051690.27461448
85Retinol metabolism_Homo sapiens_hsa008300.27240067
86Butanoate metabolism_Homo sapiens_hsa006500.26746768
87Tryptophan metabolism_Homo sapiens_hsa003800.25636163
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24636852
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22416345
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.21851106
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20536339
92Alcoholism_Homo sapiens_hsa050340.18284499
93Non-small cell lung cancer_Homo sapiens_hsa052230.17135123
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17030436
95Sulfur metabolism_Homo sapiens_hsa009200.16305920
96Antigen processing and presentation_Homo sapiens_hsa046120.16266672
97Dorso-ventral axis formation_Homo sapiens_hsa043200.15226075
98Ras signaling pathway_Homo sapiens_hsa040140.15124850
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13098857
100TGF-beta signaling pathway_Homo sapiens_hsa043500.12494928

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