ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of integrated proviral latency (GO:0075713)	6.51860458
2	regulation of transcription from RNA polymerase I promoter (GO:0006356)	5.70485925
3	ribosome assembly (GO:0042255)	5.55010771
4	DNA replication-dependent nucleosome assembly (GO:0006335)	5.36883116
5	DNA replication-dependent nucleosome organization (GO:0034723)	5.36883116
6	regulation of posttranscriptional gene silencing (GO:0060147)	5.32513259
7	regulation of gene silencing by miRNA (GO:0060964)	5.32513259
8	regulation of gene silencing by RNA (GO:0060966)	5.32513259
9	alternative mRNA splicing, via spliceosome (GO:0000380)	5.21175538
10	establishment of viral latency (GO:0019043)	4.94515138
11	chromatin remodeling at centromere (GO:0031055)	4.86837510
12	histone exchange (GO:0043486)	4.85789082
13	CENP-A containing nucleosome assembly (GO:0034080)	4.78591390
14	DNA replication-independent nucleosome assembly (GO:0006336)	4.66985984
15	DNA replication-independent nucleosome organization (GO:0034724)	4.66985984
16	formation of translation preinitiation complex (GO:0001731)	4.42156686
17	mRNA splicing, via spliceosome (GO:0000398)	4.28779265
18	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)	4.28779265
19	RNA splicing, via transesterification reactions (GO:0000375)	4.25055747
20	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	4.22186937
21	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	4.09846025
22	regulation of mitotic spindle checkpoint (GO:1903504)	4.09846025
23	DNA damage response, detection of DNA damage (GO:0042769)	4.08705915
24	DNA topological change (GO:0006265)	4.05570727
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.03919462
26	ATP-dependent chromatin remodeling (GO:0043044)	4.02947847
27	spliceosomal snRNP assembly (GO:0000387)	4.00745984
28	chaperone-mediated protein transport (GO:0072321)	3.98984844
29	mRNA splice site selection (GO:0006376)	3.86968159
30	negative regulation of mRNA metabolic process (GO:1903312)	3.82941164
31	histone mRNA metabolic process (GO:0008334)	3.77885880
32	DNA ligation (GO:0006266)	3.74520725
33	pre-miRNA processing (GO:0031054)	3.74256375
34	negative regulation of RNA splicing (GO:0033119)	3.74086511
35	termination of RNA polymerase II transcription (GO:0006369)	3.71778486
36	negative regulation of mRNA processing (GO:0050686)	3.71082146
37	regulation of centriole replication (GO:0046599)	3.68452697
38	regulation of DNA endoreduplication (GO:0032875)	3.62109661
39	protein localization to kinetochore (GO:0034501)	3.60065023
40	regulation of histone H3-K9 methylation (GO:0051570)	3.54420766
41	chromatin assembly or disassembly (GO:0006333)	3.44719218
42	mitotic metaphase plate congression (GO:0007080)	3.39026546
43	RNA splicing (GO:0008380)	3.38672486
44	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.37974092
45	termination of RNA polymerase III transcription (GO:0006386)	3.37974092
46	regulation of helicase activity (GO:0051095)	3.37531310
47	heterochromatin organization (GO:0070828)	3.36503391
48	regulation of mRNA stability (GO:0043488)	3.34431805
49	ncRNA catabolic process (GO:0034661)	3.33850852
50	cytoplasmic mRNA processing body assembly (GO:0033962)	3.31548332
51	DNA unwinding involved in DNA replication (GO:0006268)	3.29487517
52	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.27500835
53	ribonucleoprotein complex assembly (GO:0022618)	3.26582145
54	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.23473417
55	peptidyl-threonine dephosphorylation (GO:0035970)	3.20017726
56	DNA-templated transcription, termination (GO:0006353)	3.18316358
57	protein complex localization (GO:0031503)	3.17828977
58	ribosome biogenesis (GO:0042254)	3.16817586
59	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.15335674
60	positive regulation of RNA splicing (GO:0033120)	3.14834971
61	maturation of 5.8S rRNA (GO:0000460)	3.14499550
62	pseudouridine synthesis (GO:0001522)	3.12046678
63	ribonucleoprotein complex subunit organization (GO:0071826)	3.10577937
64	telomere maintenance via telomerase (GO:0007004)	3.10384252
65	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.09522409
66	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.09045388
67	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.05599983
68	negative regulation of histone methylation (GO:0031061)	3.05552775
69	spliceosomal complex assembly (GO:0000245)	3.03635670
70	DNA replication checkpoint (GO:0000076)	3.02787742
71	regulation of RNA stability (GO:0043487)	3.02182895
72	positive regulation of response to oxidative stress (GO:1902884)	3.01171628
73	positive regulation of cellular response to oxidative stress (GO:1900409)	3.01171628
74	histone H2B ubiquitination (GO:0033523)	3.00198637
75	mRNA stabilization (GO:0048255)	2.99611094
76	RNA stabilization (GO:0043489)	2.99611094
77	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.94504768
78	regulation of translation, ncRNA-mediated (GO:0045974)	2.94504768
79	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.94504768
80	DNA strand elongation involved in DNA replication (GO:0006271)	2.93844583
81	rRNA modification (GO:0000154)	2.90887866
82	proteasome assembly (GO:0043248)	2.90751092
83	positive regulation of histone H3-K4 methylation (GO:0051571)	2.90589753
84	mitotic sister chromatid cohesion (GO:0007064)	2.89036401
85	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.84040693
86	IMP metabolic process (GO:0046040)	2.83523253
87	transcription from mitochondrial promoter (GO:0006390)	2.82696504
88	rRNA processing (GO:0006364)	2.80279964
89	7-methylguanosine mRNA capping (GO:0006370)	2.79618426
90	maturation of SSU-rRNA (GO:0030490)	2.78953916
91	positive regulation of mRNA processing (GO:0050685)	2.75645580
92	DNA strand elongation (GO:0022616)	2.75632873
93	mRNA processing (GO:0006397)	2.75576779
94	regulation of gene silencing (GO:0060968)	2.74664835
95	positive regulation of DNA-templated transcription, elongation (GO:0032786)	2.73610591
96	7-methylguanosine RNA capping (GO:0009452)	2.73211283
97	RNA capping (GO:0036260)	2.73211283
98	negative regulation of fibroblast apoptotic process (GO:2000270)	2.72591750
99	ribonucleoprotein complex biogenesis (GO:0022613)	2.71587200
100	rRNA metabolic process (GO:0016072)	2.71019356

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.04005973
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.18549789
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.77556917
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.65691827
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.34725226
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.28661087
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.97552795
8	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.88057787
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.87755074
10	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.65511616
11	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.64165558
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.60492732
13	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.55905109
14	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.54773040
15	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.53916013
16	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.41090058
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.39542944
18	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.36018912
19	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.35224154
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.34020227
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.28881608
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.27802183
23	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.14733776
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.13242551
25	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.12615609
26	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.07596887
27	SOX2_16153702_ChIP-ChIP_HESCs_Human	2.04178846
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.02677201
29	EWS_26573619_Chip-Seq_HEK293_Human	1.98711047
30	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.97457434
31	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.93271218
32	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.88057981
33	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.87053179
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.86249745
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.83832501
36	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.82074460
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.81575240
38	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.74805942
39	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.74430382
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.73400311
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.73031215
42	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.73007963
43	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.69791144
44	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.64587746
45	XRN2_22483619_ChIP-Seq_HELA_Human	1.57590630
46	FUS_26573619_Chip-Seq_HEK293_Human	1.57317858
47	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.57109013
48	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.55193068
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.54467391
50	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.50410173
51	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.49675309
52	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.46887541
53	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.45610181
54	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.44791339
55	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.44791339
56	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.44791339
57	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.44570159
58	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.42657638
59	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.42240059
60	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.41398592
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.38335750
62	TAF15_26573619_Chip-Seq_HEK293_Human	1.37867135
63	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.37050114
64	AR_21909140_ChIP-Seq_LNCAP_Human	1.36087064
65	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.32884020
66	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.31864198
67	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.30607171
68	TCF3_18692474_ChIP-Seq_MESCs_Mouse	1.26880076
69	GABP_19822575_ChIP-Seq_HepG2_Human	1.23901674
70	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.23603716
71	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.20924345
72	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.20585206
73	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.19441924
74	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.18756785
75	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.16945080
76	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.16835610
77	DCP1A_22483619_ChIP-Seq_HELA_Human	1.13384965
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10903200
79	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.09908012
80	P300_19829295_ChIP-Seq_ESCs_Human	1.09028720
81	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.06215915
82	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.02154276
83	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	1.00526551
84	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.97294476
85	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97145838
86	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.95556466
87	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.94387638
88	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.93840640
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.93532291
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.90132207
91	IGF1R_20145208_ChIP-Seq_DFB_Human	0.89977935
92	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.89767767
93	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.88254593
94	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.86831261
95	IRF1_19129219_ChIP-ChIP_H3396_Human	0.85227821
96	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.83974217
97	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.83278360
98	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.81039215
99	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.80170267
100	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.79579878

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	4.04766574
2	MP0004957_abnormal_blastocyst_morpholog	3.56661970
3	MP0010094_abnormal_chromosome_stability	3.17095784
4	MP0006292_abnormal_olfactory_placode	3.02711479
5	MP0001188_hyperpigmentation	2.88214938
6	MP0003111_abnormal_nucleus_morphology	2.87111400
7	MP0001293_anophthalmia	2.82404194
8	MP0008877_abnormal_DNA_methylation	2.62521837
9	MP0008058_abnormal_DNA_repair	2.44557819
10	MP0003567_abnormal_fetal_cardiomyocyte	2.36255531
11	MP0003941_abnormal_skin_development	2.31610867
12	MP0003121_genomic_imprinting	2.28213370
13	MP0003077_abnormal_cell_cycle	2.23817976
14	MP0002877_abnormal_melanocyte_morpholog	2.18476636
15	MP0000537_abnormal_urethra_morphology	2.17388745
16	MP0001730_embryonic_growth_arrest	2.10728905
17	MP0006072_abnormal_retinal_apoptosis	2.08088133
18	MP0003123_paternal_imprinting	2.07805184
19	MP0008932_abnormal_embryonic_tissue	2.07800907
20	MP0002254_reproductive_system_inflammat	2.00391669
21	MP0009672_abnormal_birth_weight	1.95810849
22	MP0003122_maternal_imprinting	1.93452288
23	MP0002697_abnormal_eye_size	1.77897333
24	MP0003890_abnormal_embryonic-extraembry	1.77436503
25	MP0003937_abnormal_limbs/digits/tail_de	1.76421317
26	MP0002736_abnormal_nociception_after	1.69857623
27	MP0000350_abnormal_cell_proliferation	1.61053089
28	MP0002085_abnormal_embryonic_tissue	1.54522779
29	MP0000778_abnormal_nervous_system	1.54469502
30	MP0002084_abnormal_developmental_patter	1.49326103
31	MP0005377_hearing/vestibular/ear_phenot	1.46241396
32	MP0003878_abnormal_ear_physiology	1.46241396
33	MP0009379_abnormal_foot_pigmentation	1.45781305
34	MP0004197_abnormal_fetal_growth/weight/	1.45195945
35	MP0004885_abnormal_endolymph	1.43699998
36	MP0003119_abnormal_digestive_system	1.42988920
37	MP0001697_abnormal_embryo_size	1.38796333
38	MP0001286_abnormal_eye_development	1.34308713
39	MP0003787_abnormal_imprinting	1.33417745
40	MP0002233_abnormal_nose_morphology	1.32679370
41	MP0008057_abnormal_DNA_replication	1.29927324
42	MP0003861_abnormal_nervous_system	1.25932918
43	MP0003136_yellow_coat_color	1.22141703
44	MP0004133_heterotaxia	1.21182548
45	MP0005380_embryogenesis_phenotype	1.20740651
46	MP0001672_abnormal_embryogenesis/_devel	1.20740651
47	MP0000049_abnormal_middle_ear	1.19523300
48	MP0003718_maternal_effect	1.18271778
49	MP0009703_decreased_birth_body	1.16782233
50	MP0004859_abnormal_synaptic_plasticity	1.16262726
51	MP0001984_abnormal_olfaction	1.16216267
52	MP0001299_abnormal_eye_distance/	1.15995331
53	MP0004270_analgesia	1.15847492
54	MP0003984_embryonic_growth_retardation	1.12964549
55	MP0002080_prenatal_lethality	1.11889570
56	MP0001177_atelectasis	1.11730620
57	MP0002088_abnormal_embryonic_growth/wei	1.10457693
58	MP0001727_abnormal_embryo_implantation	1.10071369
59	MP0001485_abnormal_pinna_reflex	1.09543800
60	MP0002735_abnormal_chemical_nociception	1.05978124
61	MP0002111_abnormal_tail_morphology	1.04980940
62	MP0003938_abnormal_ear_development	1.04011337
63	MP0003315_abnormal_perineum_morphology	1.03214785
64	MP0002909_abnormal_adrenal_gland	1.03169441
65	MP0005084_abnormal_gallbladder_morpholo	1.01099987
66	MP0008007_abnormal_cellular_replicative	0.99211791
67	MP0008789_abnormal_olfactory_epithelium	0.98992784
68	MP0000579_abnormal_nail_morphology	0.98889625
69	MP0002092_abnormal_eye_morphology	0.98242897
70	MP0005391_vision/eye_phenotype	0.98203249
71	MP0005499_abnormal_olfactory_system	0.98150547
72	MP0005394_taste/olfaction_phenotype	0.98150547
73	MP0000428_abnormal_craniofacial_morphol	0.96902839
74	MP0000631_abnormal_neuroendocrine_gland	0.92599027
75	MP0002081_perinatal_lethality	0.92472860
76	MP0001529_abnormal_vocalization	0.91035910
77	MP0003283_abnormal_digestive_organ	0.90092756
78	MP0001968_abnormal_touch/_nociception	0.87515526
79	MP0002938_white_spotting	0.86713822
80	MP0002751_abnormal_autonomic_nervous	0.86327192
81	MP0005187_abnormal_penis_morphology	0.85934735
82	MP0002102_abnormal_ear_morphology	0.85435500
83	MP0005645_abnormal_hypothalamus_physiol	0.85016752
84	MP0002152_abnormal_brain_morphology	0.84110603
85	MP0000432_abnormal_head_morphology	0.84082444
86	MP0004185_abnormal_adipocyte_glucose	0.82754194
87	MP0005253_abnormal_eye_physiology	0.82030039
88	MP0000955_abnormal_spinal_cord	0.81860393
89	MP0008770_decreased_survivor_rate	0.81400606
90	MP0004811_abnormal_neuron_physiology	0.80986526
91	MP0006035_abnormal_mitochondrial_morpho	0.80970897
92	MP0009053_abnormal_anal_canal	0.79404260
93	MP0000313_abnormal_cell_death	0.78831888
94	MP0002184_abnormal_innervation	0.78657600
95	MP0002086_abnormal_extraembryonic_tissu	0.76450769
96	MP0002210_abnormal_sex_determination	0.75899884
97	MP0001145_abnormal_male_reproductive	0.73219245
98	MP0003385_abnormal_body_wall	0.73133139
99	MP0002177_abnormal_outer_ear	0.72974144
100	MP0003755_abnormal_palate_morphology	0.70916262

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.68801536
2	Septo-optic dysplasia (HP:0100842)	3.55685024
3	Volvulus (HP:0002580)	3.46753590
4	Spastic diplegia (HP:0001264)	3.34790699
5	Pendular nystagmus (HP:0012043)	3.19940062
6	Increased hepatocellular lipid droplets (HP:0006565)	3.16079307
7	Acute encephalopathy (HP:0006846)	3.14499817
8	Multiple enchondromatosis (HP:0005701)	3.13771731
9	Colon cancer (HP:0003003)	3.07354678
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.00079495
11	Shoulder girdle muscle weakness (HP:0003547)	2.96188587
12	Progressive macrocephaly (HP:0004481)	2.92406112
13	Chronic bronchitis (HP:0004469)	2.74805167
14	Abnormality of the musculature of the pelvis (HP:0001469)	2.74358721
15	Abnormality of the hip-girdle musculature (HP:0001445)	2.74358721
16	Hyperglycinemia (HP:0002154)	2.71229964
17	Pelvic girdle muscle weakness (HP:0003749)	2.70543028
18	Lipid accumulation in hepatocytes (HP:0006561)	2.65744245
19	Abnormal number of incisors (HP:0011064)	2.64059462
20	Abnormality of the labia minora (HP:0012880)	2.63861364
21	Cerebral edema (HP:0002181)	2.58554948
22	Mitochondrial inheritance (HP:0001427)	2.56069907
23	Leukodystrophy (HP:0002415)	2.55332260
24	Abnormality of the septum pellucidum (HP:0007375)	2.54202320
25	Oral leukoplakia (HP:0002745)	2.54025917
26	Biliary tract neoplasm (HP:0100574)	2.50753034
27	Limb-girdle muscle atrophy (HP:0003797)	2.46055736
28	Methylmalonic acidemia (HP:0002912)	2.33850934
29	Absent septum pellucidum (HP:0001331)	2.27480995
30	Increased CSF lactate (HP:0002490)	2.24176968
31	Abnormality of serum amino acid levels (HP:0003112)	2.22577531
32	Hepatoblastoma (HP:0002884)	2.22265442
33	Renal Fanconi syndrome (HP:0001994)	2.21553916
34	Calcaneovalgus deformity (HP:0001848)	2.15422099
35	Gonadotropin excess (HP:0000837)	2.14700936
36	Dysphonia (HP:0001618)	2.10883416
37	Facial cleft (HP:0002006)	2.06534905
38	Macrocytic anemia (HP:0001972)	2.06102763
39	Increased intramyocellular lipid droplets (HP:0012240)	2.05311259
40	Megaloblastic anemia (HP:0001889)	2.02841398
41	Abnormality of homocysteine metabolism (HP:0010919)	2.02625174
42	Homocystinuria (HP:0002156)	2.02625174
43	Cortical dysplasia (HP:0002539)	2.00262012
44	Cellular immunodeficiency (HP:0005374)	1.99134084
45	Absent eyebrow (HP:0002223)	1.97844235
46	Maternal diabetes (HP:0009800)	1.95440211
47	Horseshoe kidney (HP:0000085)	1.94082209
48	Primary amenorrhea (HP:0000786)	1.92625884
49	Impulsivity (HP:0100710)	1.90770455
50	Anencephaly (HP:0002323)	1.90177924
51	Breast aplasia (HP:0100783)	1.89259122
52	Ependymoma (HP:0002888)	1.88289221
53	Birth length less than 3rd percentile (HP:0003561)	1.87514589
54	Rhabdomyosarcoma (HP:0002859)	1.87437428
55	Inappropriate behavior (HP:0000719)	1.86658642
56	Increased nuchal translucency (HP:0010880)	1.86419083
57	Meckel diverticulum (HP:0002245)	1.85641094
58	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.85636618
59	Hyperglycinuria (HP:0003108)	1.84000077
60	Pancreatic fibrosis (HP:0100732)	1.83373115
61	Deformed tarsal bones (HP:0008119)	1.83336956
62	Erectile abnormalities (HP:0100639)	1.81813876
63	Hypoglycemic seizures (HP:0002173)	1.81287254
64	Sensorimotor neuropathy (HP:0007141)	1.80482636
65	Optic nerve hypoplasia (HP:0000609)	1.78376482
66	Bilateral microphthalmos (HP:0007633)	1.76091766
67	Decreased muscle mass (HP:0003199)	1.75821636
68	Esophageal atresia (HP:0002032)	1.75235290
69	Aplasia/Hypoplasia of the breasts (HP:0010311)	1.74661208
70	Postnatal microcephaly (HP:0005484)	1.73110204
71	Morphological abnormality of the middle ear (HP:0008609)	1.72643406
72	Rib fusion (HP:0000902)	1.72526295
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.72026987
74	Coarctation of aorta (HP:0001680)	1.71897110
75	Stenosis of the external auditory canal (HP:0000402)	1.71397783
76	Abnormality of the ileum (HP:0001549)	1.70635237
77	Megalencephaly (HP:0001355)	1.70025362
78	Unilateral renal agenesis (HP:0000122)	1.69370628
79	Hypogonadotrophic hypogonadism (HP:0000044)	1.69124730
80	Absent hair (HP:0002298)	1.67617209
81	Abnormal lung lobation (HP:0002101)	1.67313049
82	Hyperphosphaturia (HP:0003109)	1.66651562
83	Abnormality of serine family amino acid metabolism (HP:0010894)	1.66264535
84	Abnormality of glycine metabolism (HP:0010895)	1.66264535
85	Progressive muscle weakness (HP:0003323)	1.66164315
86	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.64559577
87	Bile duct proliferation (HP:0001408)	1.64419737
88	Abnormal biliary tract physiology (HP:0012439)	1.64419737
89	Neoplasm of the colon (HP:0100273)	1.63597321
90	Abnormality of the pons (HP:0007361)	1.63510725
91	Hypoplasia of the pons (HP:0012110)	1.63201157
92	Restlessness (HP:0000711)	1.61047875
93	Abolished electroretinogram (ERG) (HP:0000550)	1.60780136
94	Small hand (HP:0200055)	1.60735601
95	Pseudobulbar signs (HP:0002200)	1.60731113
96	Neoplasm of the pancreas (HP:0002894)	1.59609788
97	Abnormal hair whorl (HP:0010721)	1.59449384
98	Methylmalonic aciduria (HP:0012120)	1.59167185
99	Abnormality of methionine metabolism (HP:0010901)	1.57591110
100	Abnormality of chromosome stability (HP:0003220)	1.57194657

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	5.29073540
2	TNIK	4.99559307
3	MKNK2	4.24570323
4	SRPK1	3.81195865
5	MKNK1	3.74489393
6	CDK12	3.23639916
7	RPS6KA4	3.05978494
8	ALK	2.67529905
9	VRK2	2.49141426
10	PLK3	2.43474825
11	BRD4	2.18189264
12	TAF1	2.07825749
13	VRK1	2.00627618
14	ZAK	1.92920715
15	PNCK	1.90375324
16	STK24	1.85788184
17	TTK	1.84448607
18	STK38L	1.83435353
19	TSSK6	1.71403818
20	STK16	1.60426094
21	LATS2	1.57827630
22	MST4	1.35741074
23	BCR	1.29368120
24	LATS1	1.22369260
25	CDK19	1.21793721
26	DYRK2	1.17848861
27	DYRK3	1.14370608
28	KDR	1.12900134
29	PLK1	1.11512561
30	PBK	1.07418286
31	STK3	1.06605993
32	CASK	1.06144661
33	MAP3K4	1.02647567
34	NEK2	1.00470471
35	ATR	1.00174335
36	CSNK1E	0.97435524
37	PLK2	0.95570083
38	NEK1	0.93853364
39	NUAK1	0.92935554
40	TIE1	0.91756250
41	CHEK1	0.91609735
42	NTRK1	0.87933761
43	CAMK1G	0.87548433
44	RPS6KA5	0.85317217
45	CDK6	0.80883620
46	PLK4	0.79426277
47	NME1	0.79116365
48	MAP3K9	0.77728626
49	CSNK2A2	0.77497872
50	RPS6KB2	0.75989863
51	CDK3	0.73278501
52	ATM	0.71644182
53	CSNK1G2	0.70671283
54	WNK3	0.69367442
55	CDK4	0.65461333
56	CHEK2	0.64739639
57	CSNK1D	0.63814971
58	AURKB	0.62582902
59	WEE1	0.62572487
60	CDK7	0.61651663
61	AURKA	0.60639326
62	STK4	0.60583302
63	CDK2	0.57776007
64	UHMK1	0.57614821
65	CSNK1G1	0.57027365
66	CDK1	0.56961095
67	CSNK2A1	0.55964028
68	EPHB2	0.55663304
69	BUB1	0.54719771
70	PRKDC	0.54545112
71	YES1	0.53851288
72	ERBB4	0.50565466
73	CLK1	0.47863053
74	CDK11A	0.47032798
75	PRKCG	0.45144383
76	MARK1	0.45087682
77	MAP2K7	0.44514069
78	OXSR1	0.44491329
79	DYRK1A	0.44444998
80	CAMK1D	0.42999950
81	FGFR1	0.42854975
82	FGR	0.42380841
83	CDK18	0.42182924
84	MAP3K10	0.41574971
85	CDK15	0.41034038
86	GSK3B	0.37259174
87	MAPK14	0.36134759
88	CDK14	0.35055109
89	RPS6KA1	0.32310613
90	CSNK1A1	0.30412680
91	PIM1	0.30302490
92	BMPR1B	0.30257831
93	MAPK9	0.29903052
94	TLK1	0.29551978
95	PRKACB	0.28330818
96	CDK9	0.27065321
97	TRIM28	0.26757869
98	MAP2K2	0.26574909
99	NLK	0.23119118
100	MOS	0.22951127

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Spliceosome_Homo sapiens_hsa03040	4.80480965
2	Protein export_Homo sapiens_hsa03060	3.53034623
3	DNA replication_Homo sapiens_hsa03030	3.46720991
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.44517797
5	RNA polymerase_Homo sapiens_hsa03020	3.40412975
6	Proteasome_Homo sapiens_hsa03050	3.31397756
7	Mismatch repair_Homo sapiens_hsa03430	3.25737169
8	RNA transport_Homo sapiens_hsa03013	2.92522920
9	RNA degradation_Homo sapiens_hsa03018	2.72827881
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.57592137
11	Ribosome_Homo sapiens_hsa03010	2.56609210
12	mRNA surveillance pathway_Homo sapiens_hsa03015	2.36469952
13	Parkinsons disease_Homo sapiens_hsa05012	2.20373932
14	Non-homologous end-joining_Homo sapiens_hsa03450	2.16579081
15	Basal transcription factors_Homo sapiens_hsa03022	2.15071273
16	Selenocompound metabolism_Homo sapiens_hsa00450	2.13415117
17	Homologous recombination_Homo sapiens_hsa03440	2.12114992
18	Base excision repair_Homo sapiens_hsa03410	2.10900725
19	Huntingtons disease_Homo sapiens_hsa05016	1.97529637
20	One carbon pool by folate_Homo sapiens_hsa00670	1.76569041
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.66247262
22	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.56372841
23	Alzheimers disease_Homo sapiens_hsa05010	1.55004403
24	Cell cycle_Homo sapiens_hsa04110	1.51839340
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.46128527
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.32731474
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.30248541
28	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.27420935
29	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.23176965
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.22591517
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.22446992
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.19258486
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.15578008
34	Purine metabolism_Homo sapiens_hsa00230	1.14714922
35	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.11349197
36	Nicotine addiction_Homo sapiens_hsa05033	1.09725215
37	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97845406
38	Tight junction_Homo sapiens_hsa04530	0.90791520
39	Thyroid cancer_Homo sapiens_hsa05216	0.88988697
40	Wnt signaling pathway_Homo sapiens_hsa04310	0.85742885
41	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.84156850
42	Basal cell carcinoma_Homo sapiens_hsa05217	0.82619935
43	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.82034830
44	Oocyte meiosis_Homo sapiens_hsa04114	0.78872676
45	Folate biosynthesis_Homo sapiens_hsa00790	0.78651926
46	Phototransduction_Homo sapiens_hsa04744	0.77641883
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.76525980
48	Propanoate metabolism_Homo sapiens_hsa00640	0.75072400
49	Adherens junction_Homo sapiens_hsa04520	0.73035167
50	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64027435
51	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.63703096
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.61096575
53	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.60465414
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60136917
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.59543671
56	Hippo signaling pathway_Homo sapiens_hsa04390	0.58667691
57	Steroid biosynthesis_Homo sapiens_hsa00100	0.55908387
58	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.54412597
59	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.49130177
60	Alcoholism_Homo sapiens_hsa05034	0.47877061
61	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.45943100
62	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.43610913
63	Metabolic pathways_Homo sapiens_hsa01100	0.40292928
64	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.39125200
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.35848130
66	Colorectal cancer_Homo sapiens_hsa05210	0.34546567
67	Axon guidance_Homo sapiens_hsa04360	0.34374658
68	Protein digestion and absorption_Homo sapiens_hsa04974	0.33510929
69	Taste transduction_Homo sapiens_hsa04742	0.31306715
70	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.30757464
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.29647475
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28032095
73	Carbon metabolism_Homo sapiens_hsa01200	0.25858496
74	Glutamatergic synapse_Homo sapiens_hsa04724	0.25783510
75	MicroRNAs in cancer_Homo sapiens_hsa05206	0.25129187
76	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.24432949
77	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.24192470
78	Renin-angiotensin system_Homo sapiens_hsa04614	0.24024338
79	Glutathione metabolism_Homo sapiens_hsa00480	0.23847197
80	Lysine degradation_Homo sapiens_hsa00310	0.23573929
81	Serotonergic synapse_Homo sapiens_hsa04726	0.20941079
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.20670214
83	p53 signaling pathway_Homo sapiens_hsa04115	0.18108844
84	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.17961080
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.17159606
86	Sulfur relay system_Homo sapiens_hsa04122	0.16799150
87	Melanoma_Homo sapiens_hsa05218	0.14961744
88	Butanoate metabolism_Homo sapiens_hsa00650	0.14536563
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.13977769
90	Peroxisome_Homo sapiens_hsa04146	0.13657163
91	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.13521189
92	Fatty acid elongation_Homo sapiens_hsa00062	0.13417814
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.13259803
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.12523008
95	Herpes simplex infection_Homo sapiens_hsa05168	0.10135549
96	Pathways in cancer_Homo sapiens_hsa05200	0.08037066
97	Viral carcinogenesis_Homo sapiens_hsa05203	0.06719469
98	Olfactory transduction_Homo sapiens_hsa04740	0.05493337
99	Retinol metabolism_Homo sapiens_hsa00830	0.05217040
100	GABAergic synapse_Homo sapiens_hsa04727	0.05179670

HNRNPA3P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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