ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sequestering of actin monomers (GO:0042989)	4.64206859
2	neural tube formation (GO:0001841)	4.54657181
3	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.17034505
4	protein neddylation (GO:0045116)	4.16421709
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.15744832
6	ATP synthesis coupled proton transport (GO:0015986)	4.15744832
7	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.15414676
8	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.05516858
9	proteasome assembly (GO:0043248)	4.05386194
10	DNA deamination (GO:0045006)	4.02999894
11	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.97716457
12	GPI anchor metabolic process (GO:0006505)	3.97225370
13	GPI anchor biosynthetic process (GO:0006506)	3.90974572
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.64656084
15	NADH dehydrogenase complex assembly (GO:0010257)	3.64656084
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.64656084
17	organelle disassembly (GO:1903008)	3.58663958
18	chaperone-mediated protein transport (GO:0072321)	3.58102579
19	platelet dense granule organization (GO:0060155)	3.57069324
20	protein complex biogenesis (GO:0070271)	3.52409998
21	cullin deneddylation (GO:0010388)	3.51933278
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.46430878
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.46430878
24	protein prenylation (GO:0018342)	3.45181844
25	prenylation (GO:0097354)	3.45181844
26	ribonucleoprotein complex disassembly (GO:0032988)	3.45007907
27	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.39520909
28	preassembly of GPI anchor in ER membrane (GO:0016254)	3.35579474
29	nonmotile primary cilium assembly (GO:0035058)	3.31966971
30	DNA double-strand break processing (GO:0000729)	3.30208951
31	aldehyde catabolic process (GO:0046185)	3.28429695
32	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.27434676
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.23896803
34	negative regulation of heart rate (GO:0010459)	3.23189845
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.17059944
36	GTP biosynthetic process (GO:0006183)	3.14583201
37	respiratory chain complex IV assembly (GO:0008535)	3.13127733
38	axoneme assembly (GO:0035082)	3.13042943
39	respiratory electron transport chain (GO:0022904)	3.08237863
40	electron transport chain (GO:0022900)	3.06932638
41	base-excision repair, AP site formation (GO:0006285)	3.06162770
42	cornea development in camera-type eye (GO:0061303)	3.02555756
43	CENP-A containing nucleosome assembly (GO:0034080)	3.01884681
44	chromatin remodeling at centromere (GO:0031055)	3.01630481
45	protein deneddylation (GO:0000338)	3.01612454
46	glycolipid biosynthetic process (GO:0009247)	3.00256725
47	C-terminal protein lipidation (GO:0006501)	2.98621215
48	water-soluble vitamin biosynthetic process (GO:0042364)	2.97750341
49	mannosylation (GO:0097502)	2.96798885
50	DNA damage response, detection of DNA damage (GO:0042769)	2.96390710
51	regulation of cellular amino acid metabolic process (GO:0006521)	2.96355239
52	peptidyl-histidine modification (GO:0018202)	2.96163241
53	cellular ketone body metabolic process (GO:0046950)	2.95773097
54	histone H2A acetylation (GO:0043968)	2.95612900
55	regulation of cilium movement (GO:0003352)	2.92285729
56	regulation of development, heterochronic (GO:0040034)	2.91829936
57	positive regulation of mitochondrial fission (GO:0090141)	2.90375218
58	epithelial cilium movement (GO:0003351)	2.90319292
59	DNA catabolic process, exonucleolytic (GO:0000738)	2.87753098
60	intraciliary transport (GO:0042073)	2.85817711
61	histone mRNA metabolic process (GO:0008334)	2.82654803
62	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.81393612
63	cytochrome complex assembly (GO:0017004)	2.77703926
64	C-terminal protein amino acid modification (GO:0018410)	2.76958027
65	L-fucose metabolic process (GO:0042354)	2.76529987
66	L-fucose catabolic process (GO:0042355)	2.76529987
67	fucose catabolic process (GO:0019317)	2.76529987
68	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.75836765
69	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.74631943
70	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.73047832
71	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.73047832
72	serotonin receptor signaling pathway (GO:0007210)	2.72818945
73	ubiquinone metabolic process (GO:0006743)	2.72021608
74	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.71427313
75	protein polyglutamylation (GO:0018095)	2.68369786
76	left/right axis specification (GO:0070986)	2.68258537
77	cilium morphogenesis (GO:0060271)	2.67461725
78	embryonic epithelial tube formation (GO:0001838)	2.65043277
79	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.64727307
80	protein localization to cilium (GO:0061512)	2.64417900
81	resolution of meiotic recombination intermediates (GO:0000712)	2.64240262
82	spliceosomal complex assembly (GO:0000245)	2.63953845
83	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.63855644
84	isotype switching (GO:0045190)	2.63855644
85	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.63855644
86	ketone body metabolic process (GO:1902224)	2.62577939
87	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.61029847
88	spliceosomal snRNP assembly (GO:0000387)	2.59573835
89	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.59390148
90	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.59021653
91	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.59021653
92	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.59021653
93	synapsis (GO:0007129)	2.58472172
94	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.57183255
95	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.55755621
96	rRNA modification (GO:0000154)	2.53942332
97	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.52652207
98	ubiquinone biosynthetic process (GO:0006744)	2.52586173
99	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.51655003
100	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.51655003

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.82442549
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.59088390
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.20737338
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.02944810
5	VDR_22108803_ChIP-Seq_LS180_Human	3.01621836
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.96486842
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.95978049
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.88265865
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.67800970
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.51440135
11	EWS_26573619_Chip-Seq_HEK293_Human	2.50944484
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.50463394
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.28934406
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21301404
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.13404693
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.13208770
17	FUS_26573619_Chip-Seq_HEK293_Human	2.11863186
18	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.07340989
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.96193879
20	P300_19829295_ChIP-Seq_ESCs_Human	1.95594976
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.94883277
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.89628864
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.84558690
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.82384336
25	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.80373694
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72617047
27	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.70742695
28	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.68908852
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.68480741
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.66313553
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.61770003
32	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.61263391
33	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.60480544
34	GBX2_23144817_ChIP-Seq_PC3_Human	1.59215626
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56203323
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.56001438
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.54708901
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53049789
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50521366
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.50521366
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.46904606
42	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.45106685
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.41379392
44	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.38949861
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.35865318
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31933444
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31377893
48	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.31206980
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30694825
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30694825
51	GABP_19822575_ChIP-Seq_HepG2_Human	1.29209854
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28779704
53	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.28581925
54	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.28377395
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28192702
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28192702
57	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.28087816
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27901692
59	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26361026
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23304178
61	DCP1A_22483619_ChIP-Seq_HELA_Human	1.21963984
62	AR_20517297_ChIP-Seq_VCAP_Human	1.21332468
63	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.19636797
64	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.19411237
65	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19281076
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17865650
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16881995
68	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.14482811
69	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13130723
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09682197
71	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09142779
72	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.08484487
73	HTT_18923047_ChIP-ChIP_STHdh_Human	1.08421824
74	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.08088872
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06623219
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05721917
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05126617
78	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.04432520
79	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.03030384
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02454062
81	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.02417217
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.01326770
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01007025
84	NCOR_22424771_ChIP-Seq_293T_Human	1.00670223
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00178018
86	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99690569
87	TTF2_22483619_ChIP-Seq_HELA_Human	0.99244199
88	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.99095774
89	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98397463
90	EZH2_22144423_ChIP-Seq_EOC_Human	0.98145693
91	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.98143647
92	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.97980357
93	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96668831
94	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.96385104
95	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.96048827
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95472082
97	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.95169566
98	AR_25329375_ChIP-Seq_VCAP_Human	0.94423050
99	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94203767
100	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.93902666

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006072_abnormal_retinal_apoptosis	3.37631573
2	MP0002102_abnormal_ear_morphology	3.16295596
3	MP0000372_irregular_coat_pigmentation	3.14964057
4	MP0003880_abnormal_central_pattern	3.09182606
5	MP0004147_increased_porphyrin_level	2.85912295
6	MP0008877_abnormal_DNA_methylation	2.61520772
7	MP0001984_abnormal_olfaction	2.55131332
8	MP0005253_abnormal_eye_physiology	2.45039722
9	MP0006292_abnormal_olfactory_placode	2.30368554
10	MP0008995_early_reproductive_senescence	2.29666264
11	MP0003787_abnormal_imprinting	2.28523556
12	MP0008789_abnormal_olfactory_epithelium	2.24383169
13	MP0003011_delayed_dark_adaptation	2.05684841
14	MP0003806_abnormal_nucleotide_metabolis	2.00629621
15	MP0005499_abnormal_olfactory_system	1.96900497
16	MP0005394_taste/olfaction_phenotype	1.96900497
17	MP0006276_abnormal_autonomic_nervous	1.81791108
18	MP0002234_abnormal_pharynx_morphology	1.81135666
19	MP0001529_abnormal_vocalization	1.81038387
20	MP0008058_abnormal_DNA_repair	1.80981393
21	MP0008875_abnormal_xenobiotic_pharmacok	1.79778539
22	MP0005551_abnormal_eye_electrophysiolog	1.79588623
23	MP0003122_maternal_imprinting	1.72192743
24	MP0002653_abnormal_ependyma_morphology	1.71677798
25	MP0004142_abnormal_muscle_tone	1.67335820
26	MP0005645_abnormal_hypothalamus_physiol	1.65954903
27	MP0003136_yellow_coat_color	1.65305613
28	MP0001986_abnormal_taste_sensitivity	1.62102909
29	MP0003195_calcinosis	1.60940580
30	MP0004133_heterotaxia	1.58360802
31	MP0004145_abnormal_muscle_electrophysio	1.57245805
32	MP0002751_abnormal_autonomic_nervous	1.56966006
33	MP0005084_abnormal_gallbladder_morpholo	1.54418038
34	MP0002938_white_spotting	1.54413298
35	MP0005646_abnormal_pituitary_gland	1.52742762
36	MP0003718_maternal_effect	1.51737934
37	MP0009697_abnormal_copulation	1.49141799
38	MP0001764_abnormal_homeostasis	1.48551506
39	MP0005075_abnormal_melanosome_morpholog	1.47509903
40	MP0001835_abnormal_antigen_presentation	1.42428230
41	MP0008872_abnormal_physiological_respon	1.41343680
42	MP0000516_abnormal_urinary_system	1.39982674
43	MP0005367_renal/urinary_system_phenotyp	1.39982674
44	MP0010386_abnormal_urinary_bladder	1.39538541
45	MP0008961_abnormal_basal_metabolism	1.38745923
46	MP0002736_abnormal_nociception_after	1.32572816
47	MP0006054_spinal_hemorrhage	1.32424713
48	MP0002837_dystrophic_cardiac_calcinosis	1.30614340
49	MP0000049_abnormal_middle_ear	1.30555558
50	MP0004885_abnormal_endolymph	1.27059181
51	MP0003121_genomic_imprinting	1.25529606
52	MP0004782_abnormal_surfactant_physiolog	1.22941178
53	MP0001905_abnormal_dopamine_level	1.20587553
54	MP0000631_abnormal_neuroendocrine_gland	1.14900336
55	MP0003567_abnormal_fetal_cardiomyocyte	1.11467724
56	MP0003786_premature_aging	1.10874209
57	MP0001293_anophthalmia	1.07901454
58	MP0004215_abnormal_myocardial_fiber	1.06188112
59	MP0005391_vision/eye_phenotype	1.06088291
60	MP0009745_abnormal_behavioral_response	1.05775417
61	MP0002272_abnormal_nervous_system	1.04409589
62	MP0001968_abnormal_touch/_nociception	1.01798278
63	MP0002638_abnormal_pupillary_reflex	0.96573839
64	MP0005195_abnormal_posterior_eye	0.96302705
65	MP0003137_abnormal_impulse_conducting	0.94655084
66	MP0003937_abnormal_limbs/digits/tail_de	0.94366646
67	MP0002090_abnormal_vision	0.94216886
68	MP0001485_abnormal_pinna_reflex	0.91341312
69	MP0009764_decreased_sensitivity_to	0.91187095
70	MP0000427_abnormal_hair_cycle	0.90370780
71	MP0005085_abnormal_gallbladder_physiolo	0.90253264
72	MP0001486_abnormal_startle_reflex	0.89797854
73	MP0005167_abnormal_blood-brain_barrier	0.88928419
74	MP0003186_abnormal_redox_activity	0.87382664
75	MP0003119_abnormal_digestive_system	0.84053822
76	MP0006036_abnormal_mitochondrial_physio	0.80116781
77	MP0002752_abnormal_somatic_nervous	0.79150611
78	MP0004484_altered_response_of	0.78686629
79	MP0000647_abnormal_sebaceous_gland	0.78323478
80	MP0002557_abnormal_social/conspecific_i	0.78292942
81	MP0002572_abnormal_emotion/affect_behav	0.77758833
82	MP0002282_abnormal_trachea_morphology	0.77469745
83	MP0005332_abnormal_amino_acid	0.76607764
84	MP0010094_abnormal_chromosome_stability	0.76504518
85	MP0000026_abnormal_inner_ear	0.74729358
86	MP0006035_abnormal_mitochondrial_morpho	0.74312771
87	MP0001970_abnormal_pain_threshold	0.73935372
88	MP0003221_abnormal_cardiomyocyte_apopto	0.73922204
89	MP0000653_abnormal_sex_gland	0.73298479
90	MP0001929_abnormal_gametogenesis	0.70760602
91	MP0002233_abnormal_nose_morphology	0.69822695
92	MP0005410_abnormal_fertilization	0.68937639
93	MP0002095_abnormal_skin_pigmentation	0.68837499
94	MP0008932_abnormal_embryonic_tissue	0.68829592
95	MP0005389_reproductive_system_phenotype	0.68816394
96	MP0001963_abnormal_hearing_physiology	0.68811703
97	MP0001119_abnormal_female_reproductive	0.68776574
98	MP0003646_muscle_fatigue	0.68361082
99	MP0000778_abnormal_nervous_system	0.67245702
100	MP0004085_abnormal_heartbeat	0.66167149

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.37707807
2	Pancreatic cysts (HP:0001737)	4.21981191
3	Pancreatic fibrosis (HP:0100732)	4.13081948
4	Mitochondrial inheritance (HP:0001427)	3.62920173
5	Lipid accumulation in hepatocytes (HP:0006561)	3.61283997
6	Increased hepatocellular lipid droplets (HP:0006565)	3.58233424
7	3-Methylglutaconic aciduria (HP:0003535)	3.57355096
8	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.55427590
9	Acute necrotizing encephalopathy (HP:0006965)	3.53028449
10	Increased serum pyruvate (HP:0003542)	3.45617631
11	Increased CSF lactate (HP:0002490)	3.33424683
12	Nephronophthisis (HP:0000090)	3.18706428
13	Hepatocellular necrosis (HP:0001404)	3.18480457
14	Abnormality of midbrain morphology (HP:0002418)	3.14821607
15	Molar tooth sign on MRI (HP:0002419)	3.14821607
16	Acute encephalopathy (HP:0006846)	3.11382437
17	Hepatic necrosis (HP:0002605)	3.10365672
18	Progressive macrocephaly (HP:0004481)	3.10310296
19	Abnormality of alanine metabolism (HP:0010916)	3.04895253
20	Hyperalaninemia (HP:0003348)	3.04895253
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.04895253
22	Abolished electroretinogram (ERG) (HP:0000550)	2.98281348
23	Attenuation of retinal blood vessels (HP:0007843)	2.97835498
24	Abnormal mitochondria in muscle tissue (HP:0008316)	2.93053198
25	Thyroid-stimulating hormone excess (HP:0002925)	2.89633333
26	Medial flaring of the eyebrow (HP:0010747)	2.86283512
27	Abnormality of glycolysis (HP:0004366)	2.85060142
28	Colon cancer (HP:0003003)	2.73800326
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.69718386
30	Renal Fanconi syndrome (HP:0001994)	2.68166233
31	Hypothermia (HP:0002045)	2.66674784
32	Decreased central vision (HP:0007663)	2.65433394
33	Exertional dyspnea (HP:0002875)	2.61923112
34	Anencephaly (HP:0002323)	2.53581784
35	Occipital encephalocele (HP:0002085)	2.53089678
36	Cystic liver disease (HP:0006706)	2.51705521
37	Congenital primary aphakia (HP:0007707)	2.49020496
38	Sclerocornea (HP:0000647)	2.47318724
39	Methylmalonic acidemia (HP:0002912)	2.45801745
40	Type I transferrin isoform profile (HP:0003642)	2.43010408
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.42879016
42	Abnormal protein glycosylation (HP:0012346)	2.39699820
43	Abnormal glycosylation (HP:0012345)	2.39699820
44	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.39699820
45	Abnormal protein N-linked glycosylation (HP:0012347)	2.39699820
46	Hyperglycinemia (HP:0002154)	2.39647970
47	Microvesicular hepatic steatosis (HP:0001414)	2.38733433
48	Gait imbalance (HP:0002141)	2.38190956
49	Short tibia (HP:0005736)	2.38017233
50	Abnormality of the renal medulla (HP:0100957)	2.36777373
51	Hypoproteinemia (HP:0003075)	2.36176362
52	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.32123017
53	Optic disc pallor (HP:0000543)	2.32048350
54	Nephrogenic diabetes insipidus (HP:0009806)	2.27504531
55	Male pseudohermaphroditism (HP:0000037)	2.26142469
56	Cerebral edema (HP:0002181)	2.25509774
57	Increased serum lactate (HP:0002151)	2.24261063
58	Congenital hepatic fibrosis (HP:0002612)	2.24151007
59	Glycosuria (HP:0003076)	2.22633983
60	Abnormality of urine glucose concentration (HP:0011016)	2.22633983
61	Intestinal atresia (HP:0011100)	2.20344068
62	Congenital stationary night blindness (HP:0007642)	2.19475983
63	Lactic acidosis (HP:0003128)	2.18736476
64	Postaxial foot polydactyly (HP:0001830)	2.18528838
65	Supernumerary spleens (HP:0009799)	2.13780644
66	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.13512914
67	Abnormality of serum amino acid levels (HP:0003112)	2.08049001
68	Thyroiditis (HP:0100646)	2.01569909
69	Genital tract atresia (HP:0001827)	1.98917122
70	Vaginal atresia (HP:0000148)	1.98089284
71	Stenosis of the external auditory canal (HP:0000402)	1.98041388
72	Methylmalonic aciduria (HP:0012120)	1.96604200
73	Constricted visual fields (HP:0001133)	1.94601137
74	Postaxial hand polydactyly (HP:0001162)	1.93431005
75	Increased intramyocellular lipid droplets (HP:0012240)	1.92943478
76	Respiratory failure (HP:0002878)	1.92869360
77	Preaxial hand polydactyly (HP:0001177)	1.89944132
78	Generalized aminoaciduria (HP:0002909)	1.87813408
79	Abnormality of the labia minora (HP:0012880)	1.87292109
80	Abnormal respiratory epithelium morphology (HP:0012253)	1.86665051
81	Abnormal respiratory motile cilium morphology (HP:0005938)	1.86665051
82	CNS demyelination (HP:0007305)	1.85569276
83	Reduced antithrombin III activity (HP:0001976)	1.82455410
84	Renal cortical cysts (HP:0000803)	1.81526081
85	Long nose (HP:0003189)	1.79939008
86	Dandy-Walker malformation (HP:0001305)	1.79566250
87	Median cleft lip (HP:0000161)	1.79476076
88	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.79034213
89	Increased corneal curvature (HP:0100692)	1.78453191
90	Keratoconus (HP:0000563)	1.78453191
91	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.77676474
92	Pendular nystagmus (HP:0012043)	1.77614284
93	Abnormal ciliary motility (HP:0012262)	1.77605254
94	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.75930928
95	Dicarboxylic aciduria (HP:0003215)	1.75930928
96	Progressive inability to walk (HP:0002505)	1.75150700
97	Abnormality of the anterior horn cell (HP:0006802)	1.74146627
98	Degeneration of anterior horn cells (HP:0002398)	1.74146627
99	Type II lissencephaly (HP:0007260)	1.72005800
100	Decreased testicular size (HP:0008734)	1.69881801

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.40703970
2	ERBB3	2.83117543
3	TRIM28	2.74944328
4	ZAK	2.66866842
5	CDK19	2.58733100
6	BCR	2.54346811
7	MAP2K7	2.47302066
8	FRK	2.45355583
9	MAP3K4	2.44903076
10	MKNK1	2.35566629
11	BMPR2	2.25537357
12	BUB1	2.13416640
13	WNK3	2.01713643
14	BMPR1B	1.98860802
15	NUAK1	1.94400172
16	EIF2AK3	1.94145051
17	SRPK1	1.89227165
18	TLK1	1.77367111
19	VRK2	1.72137014
20	EPHA4	1.64042032
21	ADRBK2	1.61229079
22	VRK1	1.61161995
23	GRK1	1.50981448
24	UHMK1	1.39667310
25	MAPK13	1.36456003
26	RPS6KA4	1.35472250
27	CSNK1G3	1.33674006
28	PLK3	1.28952687
29	MST4	1.26400783
30	BCKDK	1.20894364
31	CSNK1G2	1.20470225
32	TIE1	1.20445071
33	FLT3	1.20352675
34	SIK3	1.19110372
35	DYRK2	1.18996611
36	TEC	1.16641475
37	INSRR	1.15857653
38	EPHA3	1.15627435
39	TNIK	1.11968166
40	CSNK1A1L	1.11469217
41	TXK	1.07476545
42	DYRK3	1.05205455
43	CSNK1G1	1.04414687
44	RPS6KA5	1.00333974
45	TSSK6	0.99628679
46	CCNB1	0.91684475
47	MKNK2	0.90106596
48	STK16	0.89381425
49	TAOK3	0.88006185
50	PLK2	0.87702479
51	KIT	0.86488474
52	MAP3K12	0.81889303
53	PINK1	0.80364506
54	CAMKK2	0.78430254
55	PLK4	0.71990239
56	MINK1	0.70259859
57	OXSR1	0.68609045
58	PAK3	0.68259985
59	AURKB	0.66392898
60	PRKCE	0.62187998
61	EIF2AK2	0.62107030
62	ITK	0.58785806
63	NEK2	0.58719023
64	ATR	0.57018153
65	PLK1	0.56684857
66	NEK1	0.56097546
67	EIF2AK1	0.54555484
68	MATK	0.54436854
69	IRAK2	0.53862382
70	TNK2	0.53375366
71	WNK4	0.51729798
72	PBK	0.50769122
73	PTK2B	0.47156957
74	CSNK2A1	0.47120522
75	STK4	0.47107359
76	PKN1	0.46758199
77	BTK	0.44557468
78	TAF1	0.43406442
79	OBSCN	0.42043861
80	FER	0.41640532
81	MYLK	0.40907527
82	CSNK1A1	0.39182953
83	WEE1	0.35527553
84	PRKG1	0.35175678
85	MAP2K4	0.34551398
86	IGF1R	0.34534011
87	EPHB2	0.34211623
88	ACVR1B	0.33637263
89	PRKACA	0.33001189
90	FGFR2	0.32075298
91	ATM	0.30889867
92	PASK	0.30781512
93	ABL1	0.30720588
94	CAMK2A	0.30568537
95	KDR	0.30270170
96	MARK1	0.30267180
97	CAMK4	0.30099145
98	TGFBR1	0.29262066
99	CSNK2A2	0.29117106
100	DAPK2	0.28215860

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.51883540
2	Proteasome_Homo sapiens_hsa03050	3.50681725
3	Protein export_Homo sapiens_hsa03060	3.37195187
4	Asthma_Homo sapiens_hsa05310	3.32689992
5	Oxidative phosphorylation_Homo sapiens_hsa00190	3.16317651
6	Parkinsons disease_Homo sapiens_hsa05012	2.67886051
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.39164968
8	Propanoate metabolism_Homo sapiens_hsa00640	2.14094221
9	Butanoate metabolism_Homo sapiens_hsa00650	2.12947162
10	Allograft rejection_Homo sapiens_hsa05330	2.10796587
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.93861755
12	Type I diabetes mellitus_Homo sapiens_hsa04940	1.93594235
13	RNA polymerase_Homo sapiens_hsa03020	1.93260433
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.91710669
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.87879142
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.78919086
17	Basal transcription factors_Homo sapiens_hsa03022	1.76223805
18	Huntingtons disease_Homo sapiens_hsa05016	1.71001191
19	Homologous recombination_Homo sapiens_hsa03440	1.57027529
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.56868363
21	RNA degradation_Homo sapiens_hsa03018	1.53228441
22	Alzheimers disease_Homo sapiens_hsa05010	1.50456542
23	Ribosome_Homo sapiens_hsa03010	1.50262701
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.43049580
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.42131900
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.40878877
27	Spliceosome_Homo sapiens_hsa03040	1.40035270
28	Phototransduction_Homo sapiens_hsa04744	1.38519859
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.34839811
30	Base excision repair_Homo sapiens_hsa03410	1.31839536
31	Steroid biosynthesis_Homo sapiens_hsa00100	1.26490815
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.22981888
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.22734559
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.13799575
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.13373751
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.11619550
37	Caffeine metabolism_Homo sapiens_hsa00232	1.09382000
38	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.09093175
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.08355970
40	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.07243262
41	One carbon pool by folate_Homo sapiens_hsa00670	1.06348621
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.05184715
43	RNA transport_Homo sapiens_hsa03013	1.04684882
44	Peroxisome_Homo sapiens_hsa04146	1.02383302
45	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01911911
46	Pyrimidine metabolism_Homo sapiens_hsa00240	0.96843568
47	Sulfur metabolism_Homo sapiens_hsa00920	0.93889121
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.93748683
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.91809359
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.90208280
51	Antigen processing and presentation_Homo sapiens_hsa04612	0.86703575
52	Purine metabolism_Homo sapiens_hsa00230	0.85082515
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.84849316
54	Regulation of autophagy_Homo sapiens_hsa04140	0.84023456
55	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.82753559
56	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.81101609
57	Pyruvate metabolism_Homo sapiens_hsa00620	0.79939729
58	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.77415512
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75765236
60	Retinol metabolism_Homo sapiens_hsa00830	0.75764698
61	Mismatch repair_Homo sapiens_hsa03430	0.75087986
62	Fatty acid elongation_Homo sapiens_hsa00062	0.72755458
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72520941
64	Glutathione metabolism_Homo sapiens_hsa00480	0.72097153
65	Metabolic pathways_Homo sapiens_hsa01100	0.72082543
66	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.71225636
67	GABAergic synapse_Homo sapiens_hsa04727	0.70312521
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.69167466
69	Nicotine addiction_Homo sapiens_hsa05033	0.66091825
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.63034555
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62872054
72	Olfactory transduction_Homo sapiens_hsa04740	0.61233247
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60736288
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.59304128
75	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.59069203
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56543024
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.55643184
78	Fatty acid degradation_Homo sapiens_hsa00071	0.53800319
79	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53438669
80	Serotonergic synapse_Homo sapiens_hsa04726	0.52148310
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48933200
82	Taste transduction_Homo sapiens_hsa04742	0.48468700
83	Viral myocarditis_Homo sapiens_hsa05416	0.46916767
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.46853155
85	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.46585934
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44097283
87	Sulfur relay system_Homo sapiens_hsa04122	0.44090433
88	Morphine addiction_Homo sapiens_hsa05032	0.42332841
89	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.39450553
90	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38710376
91	Folate biosynthesis_Homo sapiens_hsa00790	0.38688392
92	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.38361628
93	Circadian entrainment_Homo sapiens_hsa04713	0.37343737
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35739920
95	Alcoholism_Homo sapiens_hsa05034	0.35738880
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.34431084
97	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.34198740
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.33125826
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.32512573
100	Herpes simplex infection_Homo sapiens_hsa05168	0.32294412

HNRNPA3P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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