HNRNPA3P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.36991294
2rRNA modification (GO:0000154)5.45518680
3rRNA methylation (GO:0031167)5.05283787
4proteasome assembly (GO:0043248)4.47652102
5purine-containing compound salvage (GO:0043101)4.25275336
6IMP biosynthetic process (GO:0006188)4.07040381
7exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.93815531
8positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.85543144
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.84838926
10L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.82192580
11nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.80411016
12ATP synthesis coupled proton transport (GO:0015986)3.80339942
13energy coupled proton transport, down electrochemical gradient (GO:0015985)3.80339942
14GTP biosynthetic process (GO:0006183)3.70169592
15ribosomal large subunit biogenesis (GO:0042273)3.67607030
16protein complex biogenesis (GO:0070271)3.64890833
17GMP metabolic process (GO:0046037)3.59266276
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.56421546
19NADH dehydrogenase complex assembly (GO:0010257)3.56421546
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56421546
21purine nucleobase biosynthetic process (GO:0009113)3.51267574
22mitochondrial respiratory chain complex assembly (GO:0033108)3.50714609
23nucleobase biosynthetic process (GO:0046112)3.49529574
24regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.45753652
25pseudouridine synthesis (GO:0001522)3.43387908
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43315533
27guanosine-containing compound biosynthetic process (GO:1901070)3.40120360
28negative regulation of B cell apoptotic process (GO:0002903)3.39512948
29maturation of 5.8S rRNA (GO:0000460)3.37042100
30water-soluble vitamin biosynthetic process (GO:0042364)3.35940728
31regulation of regulatory T cell differentiation (GO:0045589)3.27944617
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.27468337
33respiratory chain complex IV assembly (GO:0008535)3.27250647
34regulation of immunoglobulin secretion (GO:0051023)3.26002059
35UTP biosynthetic process (GO:0006228)3.25014143
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.24595537
37termination of RNA polymerase III transcription (GO:0006386)3.24595537
38IMP metabolic process (GO:0046040)3.23319147
39cytidine deamination (GO:0009972)3.19704142
40cytidine metabolic process (GO:0046087)3.19704142
41cytidine catabolic process (GO:0006216)3.19704142
42regulation of cellular amino acid metabolic process (GO:0006521)3.19158849
43somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19076054
44somatic hypermutation of immunoglobulin genes (GO:0016446)3.19076054
45peptidyl-histidine modification (GO:0018202)3.18994279
46L-methionine salvage (GO:0071267)3.18842961
47L-methionine biosynthetic process (GO:0071265)3.18842961
48amino acid salvage (GO:0043102)3.18842961
49somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.17270480
50somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.17270480
51isotype switching (GO:0045190)3.17270480
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15369172
53ribosome assembly (GO:0042255)3.15323123
54folic acid-containing compound biosynthetic process (GO:0009396)3.13201146
55piRNA metabolic process (GO:0034587)3.12789113
56DNA damage response, detection of DNA damage (GO:0042769)3.12144998
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10118099
58DNA catabolic process, exonucleolytic (GO:0000738)3.09799491
59signal peptide processing (GO:0006465)3.08273272
60rRNA processing (GO:0006364)3.06735161
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06111903
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06111903
63signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06111903
64cytochrome complex assembly (GO:0017004)3.04633021
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01788194
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01788194
67regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00171523
68regulation of mitotic spindle checkpoint (GO:1903504)3.00171523
69transcription elongation from RNA polymerase I promoter (GO:0006362)2.99892925
70urate metabolic process (GO:0046415)2.97712685
71signal transduction involved in DNA damage checkpoint (GO:0072422)2.96223872
72signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96223872
73termination of RNA polymerase I transcription (GO:0006363)2.93928794
74tRNA processing (GO:0008033)2.93324246
75methionine biosynthetic process (GO:0009086)2.93187811
76rRNA metabolic process (GO:0016072)2.92532497
77signal transduction involved in cell cycle checkpoint (GO:0072395)2.91861045
78preassembly of GPI anchor in ER membrane (GO:0016254)2.91845171
79cullin deneddylation (GO:0010388)2.90399838
80NAD biosynthetic process (GO:0009435)2.88650204
81tRNA modification (GO:0006400)2.87891699
82UTP metabolic process (GO:0046051)2.87635069
83dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.86600721
84protein neddylation (GO:0045116)2.85973541
85behavioral response to nicotine (GO:0035095)2.85929099
86chaperone-mediated protein transport (GO:0072321)2.84639356
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83355515
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83355515
89positive regulation of interleukin-17 production (GO:0032740)2.83262062
90purine nucleotide salvage (GO:0032261)2.79608433
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78877857
92ribosome biogenesis (GO:0042254)2.78611183
93regulation of isotype switching to IgG isotypes (GO:0048302)2.77751046
94positive regulation of isotype switching (GO:0045830)2.77516852
95tRNA metabolic process (GO:0006399)2.75885494
96somatic diversification of immunoglobulins (GO:0016445)2.75884790
97amino acid activation (GO:0043038)2.75248135
98tRNA aminoacylation (GO:0043039)2.75248135
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73395441
100positive regulation of DNA recombination (GO:0045911)2.70745774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.14551520
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.49319791
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.75420425
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.63315185
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.52665655
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.41827840
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05284065
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.96193239
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.88307334
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.87018686
11VDR_23849224_ChIP-Seq_CD4+_Human2.79241563
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46003726
13VDR_22108803_ChIP-Seq_LS180_Human2.43511856
14FOXP3_21729870_ChIP-Seq_TREG_Human2.35594953
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28106109
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.22880278
17ELK1_19687146_ChIP-ChIP_HELA_Human2.22176434
18ZNF274_21170338_ChIP-Seq_K562_Hela2.20419188
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.18037551
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14318592
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13841532
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.01869116
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00287134
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99703836
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98221942
26E2F7_22180533_ChIP-Seq_HELA_Human1.94656927
27DCP1A_22483619_ChIP-Seq_HELA_Human1.93124979
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92862450
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89814055
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.86138616
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82618921
32EWS_26573619_Chip-Seq_HEK293_Human1.80881434
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79547534
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70706936
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68100430
36IGF1R_20145208_ChIP-Seq_DFB_Human1.67067813
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.66880668
38MYC_18940864_ChIP-ChIP_HL60_Human1.64154907
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62964274
40GABP_19822575_ChIP-Seq_HepG2_Human1.60293962
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57583836
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.57392203
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55778926
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45550313
45TP53_22573176_ChIP-Seq_HFKS_Human1.44066031
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43352868
47TAF15_26573619_Chip-Seq_HEK293_Human1.39302747
48TTF2_22483619_ChIP-Seq_HELA_Human1.37255832
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31577101
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.29330428
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29330428
52ER_23166858_ChIP-Seq_MCF-7_Human1.27509774
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26979763
54FUS_26573619_Chip-Seq_HEK293_Human1.26638995
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26338327
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25166262
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23141464
58XRN2_22483619_ChIP-Seq_HELA_Human1.20742166
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19056179
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17113086
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15636108
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13966062
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.11211848
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.09888748
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08377531
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07091940
67PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07038217
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06249709
69SOX2_19829295_ChIP-Seq_ESCs_Human1.03198770
70NANOG_19829295_ChIP-Seq_ESCs_Human1.03198770
71P300_19829295_ChIP-Seq_ESCs_Human1.03149307
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02576405
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02333325
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02058732
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.01708738
76AR_20517297_ChIP-Seq_VCAP_Human0.99737448
77IRF8_21731497_ChIP-ChIP_J774_Mouse0.98135995
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96927194
79ERG_20517297_ChIP-Seq_VCAP_Human0.96195048
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96190680
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96126358
82NCOR_22424771_ChIP-Seq_293T_Human0.95571068
83CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95453725
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95204905
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92776525
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92757969
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92165029
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.91243292
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91061563
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90704490
91HOXB7_26014856_ChIP-Seq_BT474_Human0.90682864
92GATA3_26560356_Chip-Seq_TH2_Human0.90562329
93IRF1_19129219_ChIP-ChIP_H3396_Human0.90306747
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90096734
95NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89232549
96KDM5A_27292631_Chip-Seq_BREAST_Human0.87529604
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87418025
98STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87204391
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.86765901
100CBP_20019798_ChIP-Seq_JUKART_Human0.86577800

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.97080588
2MP0005671_abnormal_response_to3.39500314
3MP0003950_abnormal_plasma_membrane3.17634833
4MP0002102_abnormal_ear_morphology3.08852409
5MP0002254_reproductive_system_inflammat3.02020092
6MP0001835_abnormal_antigen_presentation2.88026189
7MP0010094_abnormal_chromosome_stability2.63903573
8MP0008877_abnormal_DNA_methylation2.63198714
9MP0003693_abnormal_embryo_hatching2.59418224
10MP0003806_abnormal_nucleotide_metabolis2.51387554
11MP0004957_abnormal_blastocyst_morpholog2.25389749
12MP0002234_abnormal_pharynx_morphology2.19328802
13MP0003195_calcinosis2.16994369
14MP0003786_premature_aging2.16265413
15MP0003718_maternal_effect2.07623070
16MP0004147_increased_porphyrin_level2.05389688
17MP0001853_heart_inflammation1.90082582
18MP0005551_abnormal_eye_electrophysiolog1.89895365
19MP0002736_abnormal_nociception_after1.88686278
20MP0008875_abnormal_xenobiotic_pharmacok1.86550398
21MP0009333_abnormal_splenocyte_physiolog1.79637040
22MP0000372_irregular_coat_pigmentation1.79138269
23MP0005645_abnormal_hypothalamus_physiol1.77211940
24MP0008057_abnormal_DNA_replication1.76490043
25MP0005410_abnormal_fertilization1.75195762
26MP0003111_abnormal_nucleus_morphology1.74840898
27MP0009697_abnormal_copulation1.74050493
28MP0005084_abnormal_gallbladder_morpholo1.67562644
29MP0002148_abnormal_hypersensitivity_rea1.65149227
30MP0000685_abnormal_immune_system1.63716531
31MP0001968_abnormal_touch/_nociception1.60076996
32MP0006035_abnormal_mitochondrial_morpho1.59391600
33MP0001790_abnormal_immune_system1.58991319
34MP0005387_immune_system_phenotype1.58991319
35MP0008872_abnormal_physiological_respon1.56122207
36MP0006036_abnormal_mitochondrial_physio1.48473466
37MP0009785_altered_susceptibility_to1.43427308
38MP0002006_tumorigenesis1.38839853
39MP0002138_abnormal_hepatobiliary_system1.34538280
40MP0003077_abnormal_cell_cycle1.32059285
41MP0006292_abnormal_olfactory_placode1.30286320
42MP0003011_delayed_dark_adaptation1.29799122
43MP0008007_abnormal_cellular_replicative1.29254678
44MP0005646_abnormal_pituitary_gland1.25462748
45MP0003763_abnormal_thymus_physiology1.25333761
46MP0001929_abnormal_gametogenesis1.19389122
47MP0010386_abnormal_urinary_bladder1.18480040
48MP0002938_white_spotting1.18103334
49MP0001919_abnormal_reproductive_system1.17659008
50MP0001873_stomach_inflammation1.16993444
51MP0002876_abnormal_thyroid_physiology1.15520927
52MP0004019_abnormal_vitamin_homeostasis1.13662130
53MP0002210_abnormal_sex_determination1.11548808
54MP0001764_abnormal_homeostasis1.10999745
55MP0003283_abnormal_digestive_organ1.09886878
56MP0002277_abnormal_respiratory_mucosa1.08957075
57MP0000613_abnormal_salivary_gland1.08109740
58MP0004145_abnormal_muscle_electrophysio1.07985355
59MP0005000_abnormal_immune_tolerance1.05498239
60MP0000604_amyloidosis1.03786997
61MP0006072_abnormal_retinal_apoptosis1.02688716
62MP0001501_abnormal_sleep_pattern1.00418291
63MP0002837_dystrophic_cardiac_calcinosis1.00081134
64MP0005389_reproductive_system_phenotype0.99402963
65MP0003646_muscle_fatigue0.98796567
66MP0001800_abnormal_humoral_immune0.98732872
67MP0005253_abnormal_eye_physiology0.95403354
68MP0000653_abnormal_sex_gland0.95009216
69MP0002751_abnormal_autonomic_nervous0.93684991
70MP0005636_abnormal_mineral_homeostasis0.93143228
71MP0005332_abnormal_amino_acid0.92631645
72MP0001145_abnormal_male_reproductive0.91975059
73MP0003698_abnormal_male_reproductive0.91794512
74MP0003186_abnormal_redox_activity0.91679473
75MP0001986_abnormal_taste_sensitivity0.90518402
76MP0008932_abnormal_embryonic_tissue0.89864278
77MP0002420_abnormal_adaptive_immunity0.88118021
78MP0001819_abnormal_immune_cell0.88069304
79MP0004782_abnormal_surfactant_physiolog0.87995366
80MP0003866_abnormal_defecation0.86970456
81MP0002160_abnormal_reproductive_system0.86824970
82MP0002090_abnormal_vision0.86704357
83MP0002166_altered_tumor_susceptibility0.83316101
84MP0002723_abnormal_immune_serum0.82714639
85MP0004142_abnormal_muscle_tone0.81842325
86MP0002733_abnormal_thermal_nociception0.81793550
87MP0002396_abnormal_hematopoietic_system0.81289405
88MP0005310_abnormal_salivary_gland0.80685228
89MP0010155_abnormal_intestine_physiology0.79641968
90MP0002272_abnormal_nervous_system0.79318376
91MP0005395_other_phenotype0.78372064
92MP0005377_hearing/vestibular/ear_phenot0.77765161
93MP0003878_abnormal_ear_physiology0.77765161
94MP0009053_abnormal_anal_canal0.77730714
95MP0008995_early_reproductive_senescence0.76972449
96MP0002452_abnormal_antigen_presenting0.76861095
97MP0002405_respiratory_system_inflammati0.76266936
98MP0002282_abnormal_trachea_morphology0.75887182
99MP0000358_abnormal_cell_content/0.75166630
100MP0000689_abnormal_spleen_morphology0.75118147

Predicted human phenotypes

RankGene SetZ-score
1Dyschromatopsia (HP:0007641)4.25923244
2Abnormality of T cell physiology (HP:0011840)4.03918588
3Testicular atrophy (HP:0000029)4.02519993
43-Methylglutaconic aciduria (HP:0003535)3.98990574
5Acute necrotizing encephalopathy (HP:0006965)3.86713884
6Abnormality of the pons (HP:0007361)3.72794174
7Mitochondrial inheritance (HP:0001427)3.70049446
8Stomatitis (HP:0010280)3.69399177
9Hepatocellular necrosis (HP:0001404)3.62125181
10Increased CSF lactate (HP:0002490)3.61995827
11Prostate neoplasm (HP:0100787)3.52233496
12Central scotoma (HP:0000603)3.50430413
13Autoimmune thrombocytopenia (HP:0001973)3.36715586
14Abnormal mitochondria in muscle tissue (HP:0008316)3.27401109
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.25814453
16Acute encephalopathy (HP:0006846)3.25192893
17Autoimmune hemolytic anemia (HP:0001890)3.11550501
18Progressive macrocephaly (HP:0004481)3.11525212
19Hepatic necrosis (HP:0002605)3.03471569
20Congenital stationary night blindness (HP:0007642)3.01530117
21Methylmalonic acidemia (HP:0002912)2.99570709
22Hypoplasia of the pons (HP:0012110)2.93670338
23Opisthotonus (HP:0002179)2.93585266
24Visual hallucinations (HP:0002367)2.93308355
25Increased hepatocellular lipid droplets (HP:0006565)2.91767483
26Lipid accumulation in hepatocytes (HP:0006561)2.87364342
27Abnormality of T cells (HP:0002843)2.87051072
28Abnormality of placental membranes (HP:0011409)2.84256700
29Amniotic constriction ring (HP:0009775)2.84256700
30Increased serum lactate (HP:0002151)2.83038785
31Cerebral edema (HP:0002181)2.66429461
32Duplicated collecting system (HP:0000081)2.56743033
33Methylmalonic aciduria (HP:0012120)2.55773906
34Cerebral hypomyelination (HP:0006808)2.55645755
35Exertional dyspnea (HP:0002875)2.53893307
36Abnormality of the labia minora (HP:0012880)2.53300253
37Pancreatic cysts (HP:0001737)2.52202556
38Abnormality of the prostate (HP:0008775)2.51474287
39Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.46163226
40Increased cerebral lipofuscin (HP:0011813)2.41470542
41Scotoma (HP:0000575)2.40377756
42Abnormality of the renal collecting system (HP:0004742)2.31656487
43Lactic acidosis (HP:0003128)2.31207449
44Microvesicular hepatic steatosis (HP:0001414)2.24170740
45Lethargy (HP:0001254)2.24037270
46Optic disc pallor (HP:0000543)2.23229408
47Abnormality of purine metabolism (HP:0004352)2.22676913
48Abnormal protein glycosylation (HP:0012346)2.22252026
49Abnormal glycosylation (HP:0012345)2.22252026
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22252026
51Abnormal protein N-linked glycosylation (HP:0012347)2.22252026
52IgG deficiency (HP:0004315)2.18633371
53Oral leukoplakia (HP:0002745)2.18176115
54Meckel diverticulum (HP:0002245)2.15380493
55Pancreatic fibrosis (HP:0100732)2.14795878
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12733941
57Renal Fanconi syndrome (HP:0001994)2.12519431
58Attenuation of retinal blood vessels (HP:0007843)2.11681038
59True hermaphroditism (HP:0010459)2.10617750
60Megaloblastic anemia (HP:0001889)2.09376922
61Abnormal rod and cone electroretinograms (HP:0008323)2.08663111
62Type I transferrin isoform profile (HP:0003642)2.07953646
63Type 2 muscle fiber atrophy (HP:0003554)2.06580596
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.06299489
65Abnormality of the vitamin B12 metabolism (HP:0004341)2.05360170
66Abnormality of the ileum (HP:0001549)2.04599026
67Respiratory failure (HP:0002878)2.03295636
68Hypomagnesemia (HP:0002917)2.03026717
69Parakeratosis (HP:0001036)2.01747233
70CNS demyelination (HP:0007305)2.01566258
71Abnormality of vitamin B metabolism (HP:0004340)2.00340275
72Increased IgM level (HP:0003496)1.99884502
73Abnormality of the preputium (HP:0100587)1.98287214
74Tetraparesis (HP:0002273)1.97453092
75Clubbing of toes (HP:0100760)1.95899554
76Spastic diplegia (HP:0001264)1.93567196
77Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92309656
78Abnormality of alanine metabolism (HP:0010916)1.91803958
79Hyperalaninemia (HP:0003348)1.91803958
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91803958
81Abolished electroretinogram (ERG) (HP:0000550)1.91441951
82Hypoproteinemia (HP:0003075)1.89186327
83Gout (HP:0001997)1.88417005
84Aplasia/Hypoplasia involving the musculature (HP:0001460)1.88172973
85Exercise intolerance (HP:0003546)1.87801312
86Nephronophthisis (HP:0000090)1.87066352
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86584139
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85465337
89Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85465337
90Increased serum pyruvate (HP:0003542)1.84019889
91Abnormality of midbrain morphology (HP:0002418)1.80553043
92Molar tooth sign on MRI (HP:0002419)1.80553043
93Abnormal biliary tract physiology (HP:0012439)1.79384883
94Bile duct proliferation (HP:0001408)1.79384883
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78878474
96CNS hypomyelination (HP:0003429)1.76936176
97Renal cortical cysts (HP:0000803)1.76085446
98Pancytopenia (HP:0001876)1.75531036
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.75494684
100Constricted visual fields (HP:0001133)1.74801545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.74230734
2NEK14.37989504
3TAF13.88845428
4NUAK13.71896903
5TSSK63.36899845
6EIF2AK32.86942108
7EIF2AK12.64210317
8TXK2.51041692
9MST42.48840919
10ZAK2.44700837
11VRK12.31004055
12MKNK12.19127293
13NME22.05966147
14MAP4K12.03453544
15MAPKAPK51.99404463
16ADRBK21.97590325
17TAOK31.88195318
18BUB11.87874819
19TRIM281.83293182
20PLK31.77059911
21BCKDK1.72101127
22SMG11.55089701
23GRK11.53349112
24PLK41.29434439
25PNCK1.26778432
26WNK31.23720460
27EIF2AK21.20916391
28DAPK11.20628833
29INSRR1.19099924
30TLK11.16260260
31WNK41.11270639
32FRK1.10570582
33DYRK21.09441368
34IKBKB0.96574748
35NME10.95611108
36TEC0.95284726
37DAPK20.94706552
38TIE10.92860218
39CDC70.91315137
40OXSR10.89304946
41PBK0.88371673
42PASK0.84616055
43FES0.84205885
44STK390.84108098
45GRK50.79380965
46TNK20.77245807
47STK160.70570747
48NEK90.67908580
49ACVR1B0.67749053
50CHEK20.67284588
51ATR0.66942813
52CSNK1A1L0.66393821
53PRKCQ0.65086723
54ALK0.64971151
55WEE10.64853680
56RPS6KA50.64809513
57PLK10.64358012
58CSNK1G30.63834212
59MAP4K20.63585125
60CAMK2D0.62646493
61SRPK10.60047080
62IKBKE0.58868565
63BMPR1B0.58451259
64BMPR20.57096029
65PAK40.57075640
66CSNK2A20.54494788
67CSNK2A10.53065014
68CSNK1G10.51938588
69KDR0.50572915
70PINK10.50515704
71TGFBR10.50440808
72AURKB0.50270319
73TTK0.47446203
74CSNK1A10.45552147
75PHKG10.44303942
76PHKG20.44303942
77STK40.44198312
78MAP3K120.43402731
79TBK10.42083302
80FGFR10.41861024
81CSNK1G20.41748186
82MAP2K60.40884666
83ITK0.40267332
84ATM0.39180965
85ADRBK10.38460831
86CHEK10.37942646
87RPS6KB10.37557031
88SYK0.37358084
89MAP3K130.36496128
90MAP3K140.35916786
91MKNK20.35629438
92BTK0.35005022
93CAMK2A0.33197452
94PLK20.32418337
95LYN0.30904975
96PRKCI0.30815918
97GSK3A0.29014519
98DAPK30.28509972
99PAK30.27597877
100CDK70.25988083

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.31577207
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08428358
3Protein export_Homo sapiens_hsa030602.78714965
4One carbon pool by folate_Homo sapiens_hsa006702.65225985
5RNA polymerase_Homo sapiens_hsa030202.30608403
6Homologous recombination_Homo sapiens_hsa034402.22943531
7Ribosome_Homo sapiens_hsa030102.22526735
8Oxidative phosphorylation_Homo sapiens_hsa001902.18946793
9Basal transcription factors_Homo sapiens_hsa030222.14019753
10Mismatch repair_Homo sapiens_hsa034302.12258007
11RNA degradation_Homo sapiens_hsa030182.09962355
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99413346
13Propanoate metabolism_Homo sapiens_hsa006401.90026382
14RNA transport_Homo sapiens_hsa030131.88903228
15Parkinsons disease_Homo sapiens_hsa050121.88868507
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87132276
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.83246253
18DNA replication_Homo sapiens_hsa030301.82298555
19Vitamin B6 metabolism_Homo sapiens_hsa007501.81214805
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75882517
21Nucleotide excision repair_Homo sapiens_hsa034201.73270608
22Primary immunodeficiency_Homo sapiens_hsa053401.71837439
23Asthma_Homo sapiens_hsa053101.69394596
24Allograft rejection_Homo sapiens_hsa053301.65648291
25Spliceosome_Homo sapiens_hsa030401.64551842
26Phototransduction_Homo sapiens_hsa047441.59562390
27Base excision repair_Homo sapiens_hsa034101.57986478
28Fanconi anemia pathway_Homo sapiens_hsa034601.54881511
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52388487
30Pyrimidine metabolism_Homo sapiens_hsa002401.50202290
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47651838
32Autoimmune thyroid disease_Homo sapiens_hsa053201.41481310
33Type I diabetes mellitus_Homo sapiens_hsa049401.38643777
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.33715217
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31518800
36Purine metabolism_Homo sapiens_hsa002301.30411649
37Huntingtons disease_Homo sapiens_hsa050161.30097876
38Non-homologous end-joining_Homo sapiens_hsa034501.29215269
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25758079
40Linoleic acid metabolism_Homo sapiens_hsa005911.24521718
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.23009406
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21700411
43Graft-versus-host disease_Homo sapiens_hsa053321.13653840
44Alzheimers disease_Homo sapiens_hsa050101.09557344
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08781992
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07860731
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06927064
48Sulfur metabolism_Homo sapiens_hsa009201.02121347
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01664218
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95004357
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87259330
52Tryptophan metabolism_Homo sapiens_hsa003800.85609217
53Ether lipid metabolism_Homo sapiens_hsa005650.83397136
54Steroid biosynthesis_Homo sapiens_hsa001000.83317895
55Antigen processing and presentation_Homo sapiens_hsa046120.79727049
56Selenocompound metabolism_Homo sapiens_hsa004500.78534640
57Butanoate metabolism_Homo sapiens_hsa006500.76623044
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75054382
59Glutathione metabolism_Homo sapiens_hsa004800.71323356
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70615315
61Metabolic pathways_Homo sapiens_hsa011000.70252066
62N-Glycan biosynthesis_Homo sapiens_hsa005100.67849264
63mRNA surveillance pathway_Homo sapiens_hsa030150.67799215
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64432199
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.64411651
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64164241
67Fatty acid metabolism_Homo sapiens_hsa012120.62463601
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62027068
69Nitrogen metabolism_Homo sapiens_hsa009100.60655153
70Pyruvate metabolism_Homo sapiens_hsa006200.59869113
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59683744
72Fatty acid degradation_Homo sapiens_hsa000710.59334654
73Peroxisome_Homo sapiens_hsa041460.59115097
74Retinol metabolism_Homo sapiens_hsa008300.58606873
75Arachidonic acid metabolism_Homo sapiens_hsa005900.57939118
76Carbon metabolism_Homo sapiens_hsa012000.56392794
77Caffeine metabolism_Homo sapiens_hsa002320.55470702
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55206349
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52929969
80Rheumatoid arthritis_Homo sapiens_hsa053230.51274186
81Mineral absorption_Homo sapiens_hsa049780.51198913
82Vitamin digestion and absorption_Homo sapiens_hsa049770.51138964
83Folate biosynthesis_Homo sapiens_hsa007900.50604184
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50459320
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47991755
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47559618
87Biosynthesis of amino acids_Homo sapiens_hsa012300.47272401
88Chemical carcinogenesis_Homo sapiens_hsa052040.46956215
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.46090903
90Fatty acid elongation_Homo sapiens_hsa000620.43759605
91Cardiac muscle contraction_Homo sapiens_hsa042600.42205018
92Measles_Homo sapiens_hsa051620.41473858
93Fatty acid biosynthesis_Homo sapiens_hsa000610.41289883
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40794628
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39110219
96Regulation of autophagy_Homo sapiens_hsa041400.38469052
97Epstein-Barr virus infection_Homo sapiens_hsa051690.35692955
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35325572
99Hematopoietic cell lineage_Homo sapiens_hsa046400.33743905
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.33673339

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