HNRNPAB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.83881791
2mitotic chromosome condensation (GO:0007076)5.51570107
3transcription from mitochondrial promoter (GO:0006390)5.50402017
4embryonic process involved in female pregnancy (GO:0060136)5.47050368
5replication fork processing (GO:0031297)5.42967854
6DNA deamination (GO:0045006)4.94364871
7ribosomal small subunit biogenesis (GO:0042274)4.91178648
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.91133679
9proline metabolic process (GO:0006560)4.82672917
10establishment of apical/basal cell polarity (GO:0035089)4.80037386
11establishment of integrated proviral latency (GO:0075713)4.77968029
12negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.71261297
13nuclear pore complex assembly (GO:0051292)4.69998122
14formation of translation preinitiation complex (GO:0001731)4.60779940
15somatic diversification of immune receptors via somatic mutation (GO:0002566)4.54356544
16somatic hypermutation of immunoglobulin genes (GO:0016446)4.54356544
17regulation of translational fidelity (GO:0006450)4.50434953
18mitotic G1 DNA damage checkpoint (GO:0031571)4.39624978
19telomere maintenance via semi-conservative replication (GO:0032201)4.33187817
20dosage compensation (GO:0007549)4.22589147
21regulation of integrin activation (GO:0033623)4.22148864
22positive regulation of protein homooligomerization (GO:0032464)4.17782342
23negative regulation of mRNA processing (GO:0050686)4.17205707
24DNA strand elongation involved in DNA replication (GO:0006271)4.16376530
25mitochondrial DNA metabolic process (GO:0032042)4.15519278
26maturation of SSU-rRNA (GO:0030490)4.10915431
27establishment of monopolar cell polarity (GO:0061162)4.07772846
28establishment or maintenance of monopolar cell polarity (GO:0061339)4.07772846
29regulation of RNA export from nucleus (GO:0046831)4.07181384
30DNA strand renaturation (GO:0000733)4.06510967
31protein localization to chromosome, centromeric region (GO:0071459)4.06293056
32negative regulation of RNA splicing (GO:0033119)4.04246896
33viral mRNA export from host cell nucleus (GO:0046784)4.02623633
34spliceosomal tri-snRNP complex assembly (GO:0000244)4.01914449
35protein complex localization (GO:0031503)4.01907061
36regulation of sister chromatid cohesion (GO:0007063)4.01725917
37mitotic metaphase plate congression (GO:0007080)4.00558734
38G1 DNA damage checkpoint (GO:0044783)3.94480807
39DNA topological change (GO:0006265)3.91506752
40DNA strand elongation (GO:0022616)3.91474866
41base-excision repair (GO:0006284)3.85451278
42mitotic G1/S transition checkpoint (GO:0044819)3.83852690
43DNA unwinding involved in DNA replication (GO:0006268)3.82988436
44nucleotide-excision repair, DNA gap filling (GO:0006297)3.81608880
45positive regulation of mitotic sister chromatid separation (GO:1901970)3.81340956
46positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.81340956
47positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.81340956
48oxidative demethylation (GO:0070989)3.76546744
49mRNA cleavage (GO:0006379)3.73445398
50establishment of viral latency (GO:0019043)3.68365534
51regulation of translational termination (GO:0006449)3.67350066
52termination of RNA polymerase II transcription (GO:0006369)3.64959249
53telomere maintenance via recombination (GO:0000722)3.63800706
54meiotic chromosome segregation (GO:0045132)3.60015334
55ribonucleoprotein complex biogenesis (GO:0022613)3.58646113
56positive regulation of chromosome segregation (GO:0051984)3.56085416
57negative regulation of mRNA metabolic process (GO:1903312)3.55489402
58viral transcription (GO:0019083)3.52888691
59chromosome condensation (GO:0030261)3.52283802
60regulation of protein homooligomerization (GO:0032462)3.51694821
61mitotic sister chromatid cohesion (GO:0007064)3.49812686
62mitotic sister chromatid segregation (GO:0000070)3.49127248
63cellular protein complex localization (GO:0034629)3.45687689
64regulation of posttranscriptional gene silencing (GO:0060147)3.43559339
65regulation of gene silencing by miRNA (GO:0060964)3.43559339
66regulation of gene silencing by RNA (GO:0060966)3.43559339
67mitotic recombination (GO:0006312)3.41544687
68translational termination (GO:0006415)3.41445167
69poly(A)+ mRNA export from nucleus (GO:0016973)3.41404841
70negative regulation of cell cycle arrest (GO:0071157)3.41114391
71pore complex assembly (GO:0046931)3.41084355
72pre-miRNA processing (GO:0031054)3.39839687
73ribosome biogenesis (GO:0042254)3.38404826
74mitotic nuclear envelope disassembly (GO:0007077)3.37286432
75kinetochore organization (GO:0051383)3.34191988
76kinetochore assembly (GO:0051382)3.33329268
77RNA stabilization (GO:0043489)3.33092294
78mRNA stabilization (GO:0048255)3.33092294
79DNA replication checkpoint (GO:0000076)3.30975818
80sister chromatid segregation (GO:0000819)3.30612726
81peptidyl-arginine omega-N-methylation (GO:0035247)3.30264289
82regulation of DNA damage checkpoint (GO:2000001)3.30184736
83nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30058662
84protein-DNA complex disassembly (GO:0032986)3.29418904
85nucleosome disassembly (GO:0006337)3.29418904
86ribosome assembly (GO:0042255)3.29349496
87nucleobase-containing small molecule interconversion (GO:0015949)3.29109571
88regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.27389077
89trophectodermal cell differentiation (GO:0001829)3.26061544
90non-recombinational repair (GO:0000726)3.23990357
91double-strand break repair via nonhomologous end joining (GO:0006303)3.23990357
92regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.23880454
93regulation of double-strand break repair via homologous recombination (GO:0010569)3.23052821
94negative regulation of JAK-STAT cascade (GO:0046426)3.22365697
95establishment of protein localization to mitochondrial membrane (GO:0090151)3.21024927
96regulation of mammary gland epithelial cell proliferation (GO:0033599)3.20935551
97protein localization to kinetochore (GO:0034501)3.20217716
98regulation of double-strand break repair (GO:2000779)3.19643647
99embryonic placenta development (GO:0001892)3.18645487
100telomere maintenance via telomere lengthening (GO:0010833)3.18154281
101ribosomal large subunit biogenesis (GO:0042273)3.17029120
102DNA double-strand break processing (GO:0000729)3.16390891
103chromatin assembly (GO:0031497)3.16033879
104histone arginine methylation (GO:0034969)3.14352675
105nuclear envelope disassembly (GO:0051081)3.13699459
106membrane disassembly (GO:0030397)3.13699459
107ribosomal small subunit assembly (GO:0000028)3.12081237
108metaphase plate congression (GO:0051310)3.11784255
109DNA conformation change (GO:0071103)3.09447197
110histone H4-K12 acetylation (GO:0043983)3.07878302
111heterochromatin organization (GO:0070828)3.07702026
112DNA duplex unwinding (GO:0032508)3.07453001
113positive regulation by host of viral transcription (GO:0043923)3.06798926
114DNA replication initiation (GO:0006270)3.05676135
115DNA geometric change (GO:0032392)3.05486238
116regulation of nucleobase-containing compound transport (GO:0032239)3.04703724
117apoptotic process involved in morphogenesis (GO:0060561)3.03332957
118L-serine metabolic process (GO:0006563)3.03241900
119mRNA export from nucleus (GO:0006406)3.02215315
120translational initiation (GO:0006413)3.00098326
121translational elongation (GO:0006414)2.99901213
122DNA packaging (GO:0006323)2.98339696
123chromatin assembly or disassembly (GO:0006333)2.98215250
124mitochondrial RNA metabolic process (GO:0000959)2.96652163
125mRNA transport (GO:0051028)2.96247153
126IMP biosynthetic process (GO:0006188)2.95034633
127DNA ligation (GO:0006266)2.94364499
128DNA integration (GO:0015074)2.94262601
129RNA export from nucleus (GO:0006405)2.93037158
130nuclear pore organization (GO:0006999)2.89383502
131resolution of meiotic recombination intermediates (GO:0000712)2.89133855
132establishment of chromosome localization (GO:0051303)2.86879657
133rRNA transcription (GO:0009303)2.86871178
134maturation of 5.8S rRNA (GO:0000460)2.86601168
135embryonic camera-type eye development (GO:0031076)2.85112735
136folic acid-containing compound biosynthetic process (GO:0009396)2.84942852
137SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.84423691
138ATP-dependent chromatin remodeling (GO:0043044)2.82444360
139nuclear envelope organization (GO:0006998)2.81415734
140viral life cycle (GO:0019058)2.81068705
1413-UTR-mediated mRNA stabilization (GO:0070935)2.79685695
142mRNA splicing, via spliceosome (GO:0000398)2.78407469
143RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.78407469
144protein targeting to ER (GO:0045047)2.78131918
145pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.77665246
146nucleobase biosynthetic process (GO:0046112)2.77586343
147cotranslational protein targeting to membrane (GO:0006613)2.77241754
148nodal signaling pathway (GO:0038092)2.76933683
149RNA splicing, via transesterification reactions (GO:0000375)2.76558930
150DNA replication-dependent nucleosome organization (GO:0034723)2.76234277
151DNA replication-dependent nucleosome assembly (GO:0006335)2.76234277
152protein complex disassembly (GO:0043241)2.75264558
153IMP metabolic process (GO:0046040)2.74773265
154cellular protein complex disassembly (GO:0043624)2.72964665
155rRNA processing (GO:0006364)2.72320087
156peptidyl-arginine methylation (GO:0018216)2.71920742
157peptidyl-arginine N-methylation (GO:0035246)2.71920742
158regulation of mitotic spindle organization (GO:0060236)2.71788832
159regulation of transcription from RNA polymerase I promoter (GO:0006356)2.70418902
160regulation of mRNA stability (GO:0043488)2.67610252
161establishment of protein localization to endoplasmic reticulum (GO:0072599)2.67418118
162planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66668750
163chromatin remodeling at centromere (GO:0031055)2.66299473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.67592722
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.87274793
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.74111690
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.19046508
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84135250
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69559118
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.64755752
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61967455
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.45784408
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35405419
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34126531
12* MYC_22102868_ChIP-Seq_BL_Human2.31095656
13* VDR_21846776_ChIP-Seq_THP-1_Human2.17543269
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.12888884
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.12888884
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.12888884
17* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97097133
18EGR1_19374776_ChIP-ChIP_THP-1_Human1.87673692
19NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83389047
20KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77889900
21E2F1_21310950_ChIP-Seq_MCF-7_Human1.75379359
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74058757
23STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72349444
24* XRN2_22483619_ChIP-Seq_HELA_Human1.69938499
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.69798562
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69737382
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69188937
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.68085700
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67378170
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63102903
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61346034
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60205913
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.59503708
34KLF4_18555785_ChIP-Seq_MESCs_Mouse1.57542703
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57023529
36NANOG_21062744_ChIP-ChIP_HESCs_Human1.56853642
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56607952
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54959722
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.53807969
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53508984
41TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52949089
42SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52515393
43* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52199201
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50922925
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50738594
46TCF3_18692474_ChIP-Seq_MESCs_Mouse1.50265930
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49817073
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47947150
49ZNF263_19887448_ChIP-Seq_K562_Human1.47429279
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46551692
51POU5F1_16518401_ChIP-PET_MESCs_Mouse1.45853490
52KDM5A_27292631_Chip-Seq_BREAST_Human1.45434516
53AR_21909140_ChIP-Seq_LNCAP_Human1.45154942
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44111358
55GABP_19822575_ChIP-Seq_HepG2_Human1.43815723
56DCP1A_22483619_ChIP-Seq_HELA_Human1.43409786
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39906523
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39861222
59* TTF2_22483619_ChIP-Seq_HELA_Human1.38092409
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35137232
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33717814
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33025369
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32773800
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27333332
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26360731
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25747566
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24745416
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.24170558
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24086280
70* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23590105
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23054926
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22683704
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.22417458
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.21815230
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20488480
76KDM2B_26808549_Chip-Seq_DND41_Human1.19345610
77VDR_23849224_ChIP-Seq_CD4+_Human1.17288223
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16044869
79NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15469204
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15306406
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14869554
82* LXR_22292898_ChIP-Seq_THP-1_Human1.14647850
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.13938384
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.13611295
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13047809
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12466186
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11933034
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11875217
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08954525
90TFEB_21752829_ChIP-Seq_HELA_Human1.08927537
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08875015
92RACK7_27058665_Chip-Seq_MCF-7_Human1.08406847
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08290559
94ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08070484
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07795043
96POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06916679
97CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05551491
98* TCF7_22412390_ChIP-Seq_EML_Mouse1.04512649
99FOXP3_21729870_ChIP-Seq_TREG_Human1.04224641
100CLOCK_20551151_ChIP-Seq_293T_Human1.04155916
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04151970
102GABP_17652178_ChIP-ChIP_JURKAT_Human1.04091357
103SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03424681
104* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03222641
105OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03157319
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02297182
107CHD1_26751641_Chip-Seq_LNCaP_Human1.02055246
108CIITA_25753668_ChIP-Seq_RAJI_Human1.01602655
109SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01585827
110* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99906095
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99334803
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98924377
113EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98715913
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98654680
115TET1_21451524_ChIP-Seq_MESCs_Mouse0.98608359
116ATF3_27146783_Chip-Seq_COLON_Human0.98271631
117* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97934487
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97753281
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97635601
120SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93989546
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90999976
122HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89436261
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89267073
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88559094
125NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.88320642
126NCOR1_26117541_ChIP-Seq_K562_Human0.88052364
127TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87807272

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.20225107
2MP0010094_abnormal_chromosome_stability3.40788174
3MP0010030_abnormal_orbit_morphology3.37632760
4MP0009278_abnormal_bone_marrow3.34120092
5MP0004957_abnormal_blastocyst_morpholog3.12824900
6MP0003111_abnormal_nucleus_morphology2.92964776
7MP0003693_abnormal_embryo_hatching2.86728890
8MP0010352_gastrointestinal_tract_polyps2.64425487
9MP0003077_abnormal_cell_cycle2.49029260
10MP0005076_abnormal_cell_differentiation2.41203633
11MP0002877_abnormal_melanocyte_morpholog2.31847959
12MP0004233_abnormal_muscle_weight2.31373875
13MP0005171_absent_coat_pigmentation2.30778049
14MP0003890_abnormal_embryonic-extraembry2.27722186
15MP0008058_abnormal_DNA_repair2.08498266
16MP0008932_abnormal_embryonic_tissue2.05470019
17MP0009672_abnormal_birth_weight2.02419829
18MP0002084_abnormal_developmental_patter1.97963686
19MP0001730_embryonic_growth_arrest1.95369891
20MP0004197_abnormal_fetal_growth/weight/1.92176654
21MP0001545_abnormal_hematopoietic_system1.91010779
22MP0005397_hematopoietic_system_phenotyp1.91010779
23MP0001697_abnormal_embryo_size1.90877100
24MP0002086_abnormal_extraembryonic_tissu1.88831802
25MP0009379_abnormal_foot_pigmentation1.88504606
26MP0000350_abnormal_cell_proliferation1.88049483
27MP0002009_preneoplasia1.87275513
28MP0003119_abnormal_digestive_system1.86043324
29MP0010234_abnormal_vibrissa_follicle1.85641194
30MP0002085_abnormal_embryonic_tissue1.83226907
31MP0003567_abnormal_fetal_cardiomyocyte1.82054085
32MP0001293_anophthalmia1.77060433
33MP0001672_abnormal_embryogenesis/_devel1.77035777
34MP0005380_embryogenesis_phenotype1.77035777
35MP0003786_premature_aging1.76312019
36MP0000490_abnormal_crypts_of1.75771020
37MP0003283_abnormal_digestive_organ1.72843949
38MP0003705_abnormal_hypodermis_morpholog1.62880505
39MP0008877_abnormal_DNA_methylation1.61251329
40MP0002653_abnormal_ependyma_morphology1.60106169
41MP0010307_abnormal_tumor_latency1.59841792
42MP0008995_early_reproductive_senescence1.57191720
43MP0009053_abnormal_anal_canal1.57138425
44MP0003984_embryonic_growth_retardation1.53261794
45MP0001346_abnormal_lacrimal_gland1.53201518
46MP0002282_abnormal_trachea_morphology1.52550590
47MP0002088_abnormal_embryonic_growth/wei1.49545577
48MP0002080_prenatal_lethality1.46008296
49MP0005451_abnormal_body_composition1.45247160
50MP0004133_heterotaxia1.45245314
51MP0008007_abnormal_cellular_replicative1.37823977
52MP0002249_abnormal_larynx_morphology1.37712538
53MP0003453_abnormal_keratinocyte_physiol1.35341352
54MP0003315_abnormal_perineum_morphology1.33118879
55MP0002396_abnormal_hematopoietic_system1.31778358
56MP0005174_abnormal_tail_pigmentation1.30869490
57MP0000678_abnormal_parathyroid_gland1.24397470
58MP0000566_synostosis1.22425936
59MP0002019_abnormal_tumor_incidence1.22411093
60MP0002111_abnormal_tail_morphology1.21823529
61MP0005623_abnormal_meninges_morphology1.19115209
62MP0000537_abnormal_urethra_morphology1.18718090
63MP0005257_abnormal_intraocular_pressure1.13082865
64MP0000313_abnormal_cell_death1.07999145
65MP0003123_paternal_imprinting1.05019244
66MP0004858_abnormal_nervous_system1.04449788
67MP0002932_abnormal_joint_morphology1.03888839
68MP0003935_abnormal_craniofacial_develop1.02833426
69MP0000371_diluted_coat_color1.02708691
70MP0006072_abnormal_retinal_apoptosis1.02075314
71MP0002089_abnormal_postnatal_growth/wei1.01449056
72MP0001881_abnormal_mammary_gland1.00123905
73MP0003937_abnormal_limbs/digits/tail_de0.99371209
74MP0003566_abnormal_cell_adhesion0.98013038
75MP0003718_maternal_effect0.96967467
76MP0001727_abnormal_embryo_implantation0.96486765
77MP0004264_abnormal_extraembryonic_tissu0.94864519
78MP0003755_abnormal_palate_morphology0.93579116
79MP0005621_abnormal_cell_physiology0.91573766
80MP0000432_abnormal_head_morphology0.90391025
81MP0002697_abnormal_eye_size0.90173430
82MP0002092_abnormal_eye_morphology0.87873161
83MP0003942_abnormal_urinary_system0.87103062
84MP0002098_abnormal_vibrissa_morphology0.86951440
85MP0001216_abnormal_epidermal_layer0.86942671
86MP0002254_reproductive_system_inflammat0.86293670
87MP0009333_abnormal_splenocyte_physiolog0.86180206
88MP0000470_abnormal_stomach_morphology0.86107348
89MP0000462_abnormal_digestive_system0.85820613
90MP0000579_abnormal_nail_morphology0.85482276
91MP0005501_abnormal_skin_physiology0.85245201
92MP0000627_abnormal_mammary_gland0.84951936
93MP0006292_abnormal_olfactory_placode0.84888934
94MP0005666_abnormal_adipose_tissue0.84774004
95MP0001286_abnormal_eye_development0.84549097
96MP0001340_abnormal_eyelid_morphology0.84291882
97MP0002114_abnormal_axial_skeleton0.83265308
98MP0005023_abnormal_wound_healing0.80850129
99MP0001348_abnormal_lacrimal_gland0.80689686
100MP0001849_ear_inflammation0.80335491
101MP0000477_abnormal_intestine_morphology0.80241438
102MP0003806_abnormal_nucleotide_metabolis0.80069923
103MP0005384_cellular_phenotype0.79847697
104MP0002796_impaired_skin_barrier0.79639030
105MP0002116_abnormal_craniofacial_bone0.79076797
106MP0002075_abnormal_coat/hair_pigmentati0.78007609
107MP0003828_pulmonary_edema0.77950341
108MP0003385_abnormal_body_wall0.76882458
109MP0001145_abnormal_male_reproductive0.76752481
110MP0004808_abnormal_hematopoietic_stem0.76004648
111MP0001915_intracranial_hemorrhage0.75946851
112MP0000762_abnormal_tongue_morphology0.75373258
113MP0009703_decreased_birth_body0.74032597
114MP0000358_abnormal_cell_content/0.73807139
115MP0002925_abnormal_cardiovascular_devel0.73658617
116MP0000703_abnormal_thymus_morphology0.72912072
117MP0002269_muscular_atrophy0.72750900
118MP0009697_abnormal_copulation0.72673105
119MP0003115_abnormal_respiratory_system0.72614060
120MP0000377_abnormal_hair_follicle0.72315456
121MP0000516_abnormal_urinary_system0.71499945
122MP0005367_renal/urinary_system_phenotyp0.71499945
123MP0004782_abnormal_surfactant_physiolog0.71391111
124MP0010630_abnormal_cardiac_muscle0.69441003
125MP0003941_abnormal_skin_development0.69354294
126MP0000467_abnormal_esophagus_morphology0.69291370
127MP0000733_abnormal_muscle_development0.69246208
128MP0000049_abnormal_middle_ear0.67936837
129MP0002060_abnormal_skin_morphology0.67388923
130MP0000428_abnormal_craniofacial_morphol0.66254780
131MP0001784_abnormal_fluid_regulation0.66023249
132MP0002210_abnormal_sex_determination0.65809409
133MP0003861_abnormal_nervous_system0.65778684
134MP0004185_abnormal_adipocyte_glucose0.64952791

Predicted human phenotypes

RankGene SetZ-score
1Facial hemangioma (HP:0000329)4.74836395
2Rib fusion (HP:0000902)4.67362757
3Poikiloderma (HP:0001029)3.89281401
4Annular pancreas (HP:0001734)3.85713156
5Concave nail (HP:0001598)3.85041804
6Ulnar bowing (HP:0003031)3.77129066
7Rectovaginal fistula (HP:0000143)3.66841910
8Rectal fistula (HP:0100590)3.66841910
9Pustule (HP:0200039)3.64346483
10Hyperacusis (HP:0010780)3.53282519
11Selective tooth agenesis (HP:0001592)3.48456999
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.44735640
13Chromsome breakage (HP:0040012)3.39879671
14Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.36104486
15Short humerus (HP:0005792)3.34181953
16Intestinal fistula (HP:0100819)3.32683469
17Aplasia/hypoplasia of the humerus (HP:0006507)3.32398284
18Progressive muscle weakness (HP:0003323)3.30186305
19Basal cell carcinoma (HP:0002671)3.26001386
20Volvulus (HP:0002580)3.23055400
21Absent radius (HP:0003974)3.22673695
22Vaginal fistula (HP:0004320)3.20514264
23Turricephaly (HP:0000262)3.14898853
24Patellar aplasia (HP:0006443)3.14573282
25Multiple enchondromatosis (HP:0005701)3.07838641
26Alopecia of scalp (HP:0002293)3.06560125
27Squamous cell carcinoma (HP:0002860)3.04253922
28Aplasia/Hypoplasia of the sacrum (HP:0008517)3.02395987
29Aplasia involving forearm bones (HP:0009822)3.02310406
30Absent forearm bone (HP:0003953)3.02310406
31Coronal craniosynostosis (HP:0004440)2.98407526
32Absent thumb (HP:0009777)2.97168655
33Tongue fasciculations (HP:0001308)2.96337483
34Aplasia/Hypoplasia of the patella (HP:0006498)2.93123661
35Orthostatic hypotension (HP:0001278)2.92121242
36Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.89847218
37Vertebral hypoplasia (HP:0008417)2.89847218
38Hypochromic microcytic anemia (HP:0004840)2.87369815
39Abnormal number of erythroid precursors (HP:0012131)2.85892064
40Increased nuchal translucency (HP:0010880)2.83172557
41Abnormal hemoglobin (HP:0011902)2.80497497
42Broad alveolar ridges (HP:0000187)2.78075427
43Insomnia (HP:0100785)2.77313208
44Intestinal atresia (HP:0011100)2.75690900
45Muscle fibrillation (HP:0010546)2.75632242
46Astrocytoma (HP:0009592)2.74374586
47Abnormality of the astrocytes (HP:0100707)2.74374586
48Ependymoma (HP:0002888)2.65821297
49Increased IgM level (HP:0003496)2.64607677
50Abnormal number of incisors (HP:0011064)2.63950573
51Microvesicular hepatic steatosis (HP:0001414)2.63864934
52Birth length less than 3rd percentile (HP:0003561)2.63775846
53Male infertility (HP:0003251)2.59909342
54Abnormality of the labia minora (HP:0012880)2.58117212
55Trismus (HP:0000211)2.56758875
56Overriding aorta (HP:0002623)2.54153529
57Congenital hip dislocation (HP:0001374)2.52170999
58Abnormality of the aortic arch (HP:0012303)2.48375984
59Progressive external ophthalmoplegia (HP:0000590)2.44852986
60Short chin (HP:0000331)2.44793529
61Premature graying of hair (HP:0002216)2.41825845
62Anteriorly placed anus (HP:0001545)2.39495794
63Cerebral aneurysm (HP:0004944)2.39241252
64High anterior hairline (HP:0009890)2.34817806
65Neoplasm of the oral cavity (HP:0100649)2.32963767
66Achilles tendon contracture (HP:0001771)2.30741195
67Vertebral fusion (HP:0002948)2.28128737
68Spastic diplegia (HP:0001264)2.26150411
69Broad distal phalanx of finger (HP:0009836)2.24007050
70Septate vagina (HP:0001153)2.23100869
71Elfin facies (HP:0004428)2.21158003
72Macrocytic anemia (HP:0001972)2.20942887
73Abnormality of male internal genitalia (HP:0000022)2.20463262
74Acute lymphatic leukemia (HP:0006721)2.18949161
75Pseudobulbar signs (HP:0002200)2.18745844
76Atresia of the external auditory canal (HP:0000413)2.17305166
77Short 5th finger (HP:0009237)2.16350274
78Bowed forearm bones (HP:0003956)2.16306539
79Bowing of the arm (HP:0006488)2.16306539
80Abnormality of the umbilical cord (HP:0010881)2.13804001
81Increased number of teeth (HP:0011069)2.13671545
82Rhabdomyosarcoma (HP:0002859)2.13538035
83Cortical dysplasia (HP:0002539)2.12788628
84Hypotelorism (HP:0000601)2.12106569
85Glioma (HP:0009733)2.11602101
86Long palpebral fissure (HP:0000637)2.10831108
87Renal duplication (HP:0000075)2.10091361
88Capillary hemangiomas (HP:0005306)2.10073299
89Duplication of thumb phalanx (HP:0009942)2.09824324
90Ragged-red muscle fibers (HP:0003200)2.08813396
91Hamartoma (HP:0010566)2.08666905
92Hypochromic anemia (HP:0001931)2.07798142
93Asymmetry of the thorax (HP:0001555)2.05774224
94Choanal stenosis (HP:0000452)2.05651134
95Medulloblastoma (HP:0002885)2.05163034
96Abnormality of the distal phalanx of the thumb (HP:0009617)2.04754320
97Premature skin wrinkling (HP:0100678)2.04736851
98Abnormality of reticulocytes (HP:0004312)2.04407880
99Colon cancer (HP:0003003)2.03795177
100Alacrima (HP:0000522)2.03738424
101Abnormality of the phalanges of the hallux (HP:0010057)2.03613393
102Gastrointestinal atresia (HP:0002589)2.01341902
103Short thumb (HP:0009778)1.99323662
104Breast hypoplasia (HP:0003187)1.97762693
105Abnormality of the ileum (HP:0001549)1.97051289
106Broad thumb (HP:0011304)1.96608612
107Overlapping toe (HP:0001845)1.96300389
108Pallor (HP:0000980)1.95500343
109Spinal muscular atrophy (HP:0007269)1.93878450
110Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.93572346
111Hypoplasia of the radius (HP:0002984)1.93566743
112Albinism (HP:0001022)1.93337934
113Nephroblastoma (Wilms tumor) (HP:0002667)1.93141772
114IgA deficiency (HP:0002720)1.93038908
115Abnormality of the fetal cardiovascular system (HP:0010948)1.92649963
116Abnormal umbilical cord blood vessels (HP:0011403)1.92649963
117Single umbilical artery (HP:0001195)1.92649963
118Abnormality of the Achilles tendon (HP:0005109)1.92450454
119Partial duplication of thumb phalanx (HP:0009944)1.91020346
120Dysautonomia (HP:0002459)1.90714718
121Proximal placement of thumb (HP:0009623)1.90421314
122Missing ribs (HP:0000921)1.89387430
123Patellar dislocation (HP:0002999)1.88247240
124Hemivertebrae (HP:0002937)1.87845405
125Split hand (HP:0001171)1.87794938
126Bifid uvula (HP:0000193)1.86746230
127Urethral obstruction (HP:0000796)1.86301390
128Hypotrichosis (HP:0001006)1.85356118
129Deviation of the thumb (HP:0009603)1.84004493
130Abnormality of the preputium (HP:0100587)1.83576964
131Neoplasm of striated muscle (HP:0009728)1.82291481
132Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82285810
133Short 4th metacarpal (HP:0010044)1.82285810
134Glossoptosis (HP:0000162)1.82211594
135Abnormality of the calcaneus (HP:0008364)1.81951234
136Pancreatic islet-cell hyperplasia (HP:0004510)1.80692929
137Rough bone trabeculation (HP:0100670)1.80616349
138Partial duplication of the phalanx of hand (HP:0009999)1.80405612
139Deep palmar crease (HP:0006191)1.76429143
140Abnormality of cells of the erythroid lineage (HP:0012130)1.75966236
141Abnormality of the salivary glands (HP:0010286)1.75150233
142Termporal pattern (HP:0011008)1.75046799
143Insidious onset (HP:0003587)1.75046799
144Disproportionate tall stature (HP:0001519)1.74651437
145Abnormality of the anterior horn cell (HP:0006802)1.74240830
146Degeneration of anterior horn cells (HP:0002398)1.74240830
147Horseshoe kidney (HP:0000085)1.73987099
148Embryonal renal neoplasm (HP:0011794)1.73299437
149Diaphragmatic weakness (HP:0009113)1.71475471
150Deep philtrum (HP:0002002)1.71215316
151Abnormality of the alveolar ridges (HP:0006477)1.71008103
152Reticulocytopenia (HP:0001896)1.70053046
153Heterotopia (HP:0002282)1.69650085
154Joint stiffness (HP:0001387)1.69596436
155Abdominal situs inversus (HP:0003363)1.69486862
156Abnormality of abdominal situs (HP:0011620)1.69486862
157Abnormality of cochlea (HP:0000375)1.66877325
158Arnold-Chiari malformation (HP:0002308)1.65488098
159Meckel diverticulum (HP:0002245)1.65125692
16011 pairs of ribs (HP:0000878)1.65077843
161Centrally nucleated skeletal muscle fibers (HP:0003687)1.64417363
162Back pain (HP:0003418)1.63544205
163Distal lower limb amyotrophy (HP:0008944)1.62348541
164Preauricular skin tag (HP:0000384)1.61916535
165Renovascular hypertension (HP:0100817)1.61842891
166Unilateral renal agenesis (HP:0000122)1.61526945
167Facial cleft (HP:0002006)1.59156462
168Premature rupture of membranes (HP:0001788)1.57571520
169Abnormality of the carotid arteries (HP:0005344)1.55961909
170Ankyloglossia (HP:0010296)1.55922742
171Progressive hearing impairment (HP:0001730)1.55874711
172Dysphonia (HP:0001618)1.55069342
173High pitched voice (HP:0001620)1.54534993
174Flared metaphyses (HP:0003015)1.54313536
175Skull defect (HP:0001362)1.53340808
176Short middle phalanx of the 5th finger (HP:0004220)1.53056940
177Spinal cord lesions (HP:0100561)1.52897641
178Syringomyelia (HP:0003396)1.52897641
179Pointed chin (HP:0000307)1.52552304
180Neoplasm of the pancreas (HP:0002894)1.50963335
181Shallow orbits (HP:0000586)1.50302220
182Myelodysplasia (HP:0002863)1.49971301
183Reticulocytosis (HP:0001923)1.49461979
184Abnormalities of placenta or umbilical cord (HP:0001194)1.48590972
185Cafe-au-lait spot (HP:0000957)1.47456927
186Hypercalcemia (HP:0003072)1.46609654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.07907833
2SMG13.94628337
3DDR23.94340507
4MAP3K63.46397679
5MAPK153.03238872
6VRK22.77943302
7MAP3K112.76385797
8CDC72.52331492
9TYRO32.49485866
10CDK72.18451190
11MATK2.14397894
12MAP3K102.12755563
13IRAK32.09744045
14FGR2.08141547
15BMX2.05137503
16PDGFRA2.04025290
17CDK122.03129067
18WEE11.89317375
19NEK21.89261933
20CDK61.81671952
21PIM21.78321679
22UHMK11.77320253
23PBK1.76326585
24DYRK1B1.71609882
25DAPK11.69176962
26PRPF4B1.62892452
27TAF11.58422779
28DYRK31.56945238
29CSK1.56704651
30TRIB31.54032045
31EIF2AK11.51602380
32YES11.51308851
33PINK11.50419169
34PRKD21.46290377
35PIM11.45819382
36RPS6KB21.44670008
37PLK11.38624224
38EEF2K1.37834318
39LATS21.37540825
40CHEK21.36934370
41BUB11.31762769
42ATR1.17774388
43SIK11.14086901
44TRPM71.10612606
45MTOR1.06800092
46NEK11.05821516
47CDK41.05059529
48PKN21.04820974
49RPS6KC11.04054562
50RPS6KL11.04054562
51TTK0.98958235
52LATS10.98048782
53MAPK110.97194268
54AURKB0.96403159
55ARAF0.94717953
56BRAF0.92830234
57PLK40.92376374
58RPS6KA60.89966741
59GSK3A0.89301237
60EPHA20.89094688
61ALK0.88541075
62CHEK10.88408456
63PLK30.87613397
64STK30.87249107
65STK100.85749123
66SCYL20.83896517
67CDK20.83791282
68MAP3K90.81274242
69MST1R0.80609284
70FGFR40.80161703
71PAK40.79717352
72MKNK10.79537524
73TTN0.78032018
74MAP3K80.77111010
75DMPK0.75499876
76ACVR1B0.73689849
77KDR0.73515772
78RPS6KA10.73163139
79CDC42BPA0.72368318
80AURKA0.71969635
81TESK20.71710518
82BRSK20.70110502
83ERN10.69273149
84ATM0.68369498
85CLK10.66876138
86MKNK20.65119165
87SRPK10.64905741
88VRK10.63951091
89TAOK20.63903895
90ILK0.62903043
91MAP2K20.61882642
92PTK20.61527539
93PAK20.61241251
94TESK10.61236866
95CDK90.60549554
96MAP3K130.58304171
97STK160.57624044
98RPS6KA40.56153805
99PTK60.55147574
100NME10.54946946
101AKT30.54338207
102RIPK10.53773190
103HIPK20.52635030
104CSNK2A10.52098726
105CDK10.51950907
106FGFR10.51540066
107CSNK2A20.50702296
108CDK11A0.48763016
109NME20.47953123
110PDGFRB0.47656837
111ERBB30.47654058
112EIF2AK20.47625704
113PASK0.46397965
114FLT30.46268764
115CAMK1D0.44517511
116CDK150.44196897
117ERBB40.43967511
118PNCK0.43839317
119TLK10.43793108
120CSNK1E0.43087456
121EGFR0.42311821
122STK40.41354589
123LRRK20.41267371
124RAF10.41252216
125BRD40.40478212
126MAPK10.40288592
127MELK0.39894683
128MAPK140.39885316
129PRKCI0.39689690
130CDK180.39604859
131TGFBR10.38385605
132MAP4K10.38123353
133PRKAA10.37189668
134RPS6KB10.36774815
135CAMK1G0.36486818
136PAK10.36376464
137AKT20.36123433
138BRSK10.34949571
139CSNK1G10.34210105
140TSSK60.33484961
141CDK80.33013393

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.77402487
2DNA replication_Homo sapiens_hsa030304.66117322
3Base excision repair_Homo sapiens_hsa034104.03845532
4Spliceosome_Homo sapiens_hsa030403.08508981
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92261436
6RNA transport_Homo sapiens_hsa030132.87621278
7Fatty acid biosynthesis_Homo sapiens_hsa000612.82617529
8Nucleotide excision repair_Homo sapiens_hsa034202.64269840
9Cell cycle_Homo sapiens_hsa041102.46329107
10mRNA surveillance pathway_Homo sapiens_hsa030152.36196341
11Homologous recombination_Homo sapiens_hsa034402.26420124
12Ribosome_Homo sapiens_hsa030101.93904301
13Fanconi anemia pathway_Homo sapiens_hsa034601.89746201
14One carbon pool by folate_Homo sapiens_hsa006701.84790287
15p53 signaling pathway_Homo sapiens_hsa041151.83414853
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73963595
17Hippo signaling pathway_Homo sapiens_hsa043901.71640391
18Notch signaling pathway_Homo sapiens_hsa043301.67185594
19Pentose phosphate pathway_Homo sapiens_hsa000301.58011587
20mTOR signaling pathway_Homo sapiens_hsa041501.56423346
21Hedgehog signaling pathway_Homo sapiens_hsa043401.51667524
22Adherens junction_Homo sapiens_hsa045201.48038090
23Basal cell carcinoma_Homo sapiens_hsa052171.37500348
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32548114
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30913639
26TGF-beta signaling pathway_Homo sapiens_hsa043501.29313587
27Vitamin B6 metabolism_Homo sapiens_hsa007501.26378608
28Bladder cancer_Homo sapiens_hsa052191.25978226
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25792862
30Carbon metabolism_Homo sapiens_hsa012001.24445839
31MicroRNAs in cancer_Homo sapiens_hsa052061.22999570
32Biosynthesis of amino acids_Homo sapiens_hsa012301.20585967
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14516419
34RNA polymerase_Homo sapiens_hsa030201.14103985
35Colorectal cancer_Homo sapiens_hsa052101.12888365
36Chronic myeloid leukemia_Homo sapiens_hsa052201.10049438
37Small cell lung cancer_Homo sapiens_hsa052221.09429031
38RNA degradation_Homo sapiens_hsa030181.09348858
39Sulfur relay system_Homo sapiens_hsa041221.08830377
40Viral carcinogenesis_Homo sapiens_hsa052031.08346885
41Oocyte meiosis_Homo sapiens_hsa041141.07684353
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06104121
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03158813
44Shigellosis_Homo sapiens_hsa051311.00665540
45Lysine degradation_Homo sapiens_hsa003100.99800280
46Pyrimidine metabolism_Homo sapiens_hsa002400.98231679
47Thyroid cancer_Homo sapiens_hsa052160.97962095
48Wnt signaling pathway_Homo sapiens_hsa043100.96634658
49Arginine and proline metabolism_Homo sapiens_hsa003300.87577066
50Proteasome_Homo sapiens_hsa030500.87569936
51Non-homologous end-joining_Homo sapiens_hsa034500.86281579
52Viral myocarditis_Homo sapiens_hsa054160.85923192
53Basal transcription factors_Homo sapiens_hsa030220.85768626
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85756683
55HTLV-I infection_Homo sapiens_hsa051660.84954151
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83606870
57Epstein-Barr virus infection_Homo sapiens_hsa051690.82543582
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82069249
59Herpes simplex infection_Homo sapiens_hsa051680.80970480
60Galactose metabolism_Homo sapiens_hsa000520.80379072
61Pyruvate metabolism_Homo sapiens_hsa006200.79571203
62Circadian rhythm_Homo sapiens_hsa047100.79360817
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78224870
64VEGF signaling pathway_Homo sapiens_hsa043700.77454265
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74675322
66Purine metabolism_Homo sapiens_hsa002300.73580446
67Acute myeloid leukemia_Homo sapiens_hsa052210.72789243
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72078365
69Systemic lupus erythematosus_Homo sapiens_hsa053220.70343711
70Folate biosynthesis_Homo sapiens_hsa007900.70020010
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67739641
72Tight junction_Homo sapiens_hsa045300.67006809
73Primary immunodeficiency_Homo sapiens_hsa053400.66628968
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66313573
75Proteoglycans in cancer_Homo sapiens_hsa052050.65453798
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.65056411
77Legionellosis_Homo sapiens_hsa051340.64482411
78Endometrial cancer_Homo sapiens_hsa052130.60735153
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60244575
80Hepatitis B_Homo sapiens_hsa051610.55698342
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55411931
82Renal cell carcinoma_Homo sapiens_hsa052110.55137820
83Prion diseases_Homo sapiens_hsa050200.55073058
84Prostate cancer_Homo sapiens_hsa052150.53112624
85Selenocompound metabolism_Homo sapiens_hsa004500.52451334
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50818079
87Pathways in cancer_Homo sapiens_hsa052000.50529625
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49728985
89Pancreatic cancer_Homo sapiens_hsa052120.48233068
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47416376
91AMPK signaling pathway_Homo sapiens_hsa041520.47387436
92Glioma_Homo sapiens_hsa052140.46397899
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46026067
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43814048
95Antigen processing and presentation_Homo sapiens_hsa046120.43584283
96Focal adhesion_Homo sapiens_hsa045100.41879300
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41772096
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39669073
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.39076911
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38269335
101Non-small cell lung cancer_Homo sapiens_hsa052230.38159179
102Huntingtons disease_Homo sapiens_hsa050160.37351486
103Apoptosis_Homo sapiens_hsa042100.36867061
104HIF-1 signaling pathway_Homo sapiens_hsa040660.34835710
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34386607
106Insulin signaling pathway_Homo sapiens_hsa049100.34011892
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.33740024
108Dorso-ventral axis formation_Homo sapiens_hsa043200.32447406
109Fructose and mannose metabolism_Homo sapiens_hsa000510.32204458
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31753378
111ErbB signaling pathway_Homo sapiens_hsa040120.31352102
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29060061
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28257738
114N-Glycan biosynthesis_Homo sapiens_hsa005100.27797788
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26525518
116Glutathione metabolism_Homo sapiens_hsa004800.26255762
117Measles_Homo sapiens_hsa051620.25648957
118B cell receptor signaling pathway_Homo sapiens_hsa046620.25034590
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23216334
120Melanoma_Homo sapiens_hsa052180.22636947
121Choline metabolism in cancer_Homo sapiens_hsa052310.22461111

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