ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of oligodendrocyte differentiation (GO:0048714)	7.07364670
2	response to lipoprotein particle (GO:0055094)	6.25696243
3	regulation of gene silencing by RNA (GO:0060966)	6.24060813
4	regulation of posttranscriptional gene silencing (GO:0060147)	6.24060813
5	regulation of gene silencing by miRNA (GO:0060964)	6.24060813
6	leukotriene biosynthetic process (GO:0019370)	6.17615594
7	dopaminergic neuron differentiation (GO:0071542)	6.09842008
8	peristalsis (GO:0030432)	5.94328740
9	ovulation cycle (GO:0042698)	5.76110575
10	positive regulation of RNA splicing (GO:0033120)	5.10128995
11	mating behavior (GO:0007617)	5.02079609
12	sulfation (GO:0051923)	4.79815975
13	embryonic body morphogenesis (GO:0010172)	4.69683397
14	somite development (GO:0061053)	4.51784063
15	behavioral response to nicotine (GO:0035095)	4.47923185
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.38959015
17	branching involved in labyrinthine layer morphogenesis (GO:0060670)	4.35484391
18	regulation of interferon-beta biosynthetic process (GO:0045357)	4.20195022
19	response to insecticide (GO:0017085)	4.10250871
20	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	4.07482870
21	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	4.06624361
22	urinary tract smooth muscle contraction (GO:0014848)	4.05835401
23	cellular response to lithium ion (GO:0071285)	4.03136224
24	positive regulation of fatty acid oxidation (GO:0046321)	3.87392259
25	dopamine biosynthetic process (GO:0042416)	3.82365503
26	peripheral nervous system axon ensheathment (GO:0032292)	3.81813409
27	myelination in peripheral nervous system (GO:0022011)	3.81813409
28	positive regulation by symbiont of host defense response (GO:0052509)	3.80508677
29	modulation by symbiont of host defense response (GO:0052031)	3.80508677
30	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	3.80508677
31	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	3.80508677
32	positive regulation by organism of defense response of other organism involved in symbiotic interact	3.80508677
33	modulation by symbiont of host immune response (GO:0052553)	3.80508677
34	alanine transport (GO:0032328)	3.77947272
35	dorsal/ventral axis specification (GO:0009950)	3.73815127
36	leukotriene metabolic process (GO:0006691)	3.73803697
37	body morphogenesis (GO:0010171)	3.72979940
38	spinal cord motor neuron differentiation (GO:0021522)	3.72030509
39	white fat cell differentiation (GO:0050872)	3.65246068
40	neurotransmitter catabolic process (GO:0042135)	3.62408136
41	regulation of oligodendrocyte differentiation (GO:0048713)	3.59114703
42	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.58567936
43	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.58567936
44	regulation of receptor binding (GO:1900120)	3.57470599
45	positive regulation of gastrulation (GO:2000543)	3.55440892
46	negative regulation of telomerase activity (GO:0051974)	3.54406277
47	regulation of somitogenesis (GO:0014807)	3.52316369
48	platelet dense granule organization (GO:0060155)	3.48503091
49	serine family amino acid catabolic process (GO:0009071)	3.47041250
50	regulation of hydrogen peroxide metabolic process (GO:0010310)	3.41627162
51	regulation of sequestering of triglyceride (GO:0010889)	3.39360709
52	DNA deamination (GO:0045006)	3.35741607
53	sequestering of extracellular ligand from receptor (GO:0035581)	3.30989169
54	fatty acid derivative biosynthetic process (GO:1901570)	3.29822156
55	icosanoid biosynthetic process (GO:0046456)	3.29822156
56	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.26875150
57	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.25707411
58	regulation of cholesterol storage (GO:0010885)	3.23484218
59	glycerol ether metabolic process (GO:0006662)	3.19144061
60	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.18781008
61	snRNA transcription (GO:0009301)	3.16574386
62	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.13839414
63	ether lipid metabolic process (GO:0046485)	3.12910757
64	phasic smooth muscle contraction (GO:0014821)	3.11284384
65	negative regulation of mast cell activation (GO:0033004)	3.09307554
66	inner ear receptor cell development (GO:0060119)	3.08996779
67	neuromuscular synaptic transmission (GO:0007274)	3.07328318
68	regulation of receptor biosynthetic process (GO:0010869)	3.06215221
69	tryptophan catabolic process (GO:0006569)	3.05610870
70	indole-containing compound catabolic process (GO:0042436)	3.05610870
71	indolalkylamine catabolic process (GO:0046218)	3.05610870
72	microglial cell activation (GO:0001774)	3.03979013
73	peptidyl-threonine dephosphorylation (GO:0035970)	3.00583369
74	flavonoid metabolic process (GO:0009812)	2.97987656
75	RNA localization (GO:0006403)	2.96866441
76	kynurenine metabolic process (GO:0070189)	2.94426532
77	ether metabolic process (GO:0018904)	2.92827494
78	pseudouridine synthesis (GO:0001522)	2.92179268
79	inner cell mass cell proliferation (GO:0001833)	2.91796619
80	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	2.90222677
81	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.90089016
82	detection of light stimulus involved in visual perception (GO:0050908)	2.89481781
83	detection of light stimulus involved in sensory perception (GO:0050962)	2.89481781
84	intracellular protein transmembrane import (GO:0044743)	2.87005970
85	negative regulation of axon guidance (GO:1902668)	2.86999414
86	positive regulation of glial cell differentiation (GO:0045687)	2.84073439
87	regulation of collateral sprouting (GO:0048670)	2.83994175
88	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.80881438
89	ubiquinone biosynthetic process (GO:0006744)	2.80409410
90	notochord development (GO:0030903)	2.79355210
91	proline transport (GO:0015824)	2.79208532
92	epithelial cilium movement (GO:0003351)	2.79011156
93	regulation of gene silencing (GO:0060968)	2.78716831
94	neuronal action potential (GO:0019228)	2.76461987
95	photoreceptor cell development (GO:0042461)	2.76141946
96	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.74519549
97	regulation of catecholamine metabolic process (GO:0042069)	2.73774776
98	regulation of dopamine metabolic process (GO:0042053)	2.73774776
99	response to misfolded protein (GO:0051788)	2.72567486
100	regulation of interferon-gamma biosynthetic process (GO:0045072)	2.72483627

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.81807244
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	5.66158102
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.32805577
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.50193865
5	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.38580133
6	FUS_26573619_Chip-Seq_HEK293_Human	2.29552493
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.19915760
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.18517274
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.14176016
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.12643677
11	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.10590695
12	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.01731102
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99070908
14	TAF15_26573619_Chip-Seq_HEK293_Human	1.92812106
15	IRF1_19129219_ChIP-ChIP_H3396_Human	1.86359557
16	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.84723193
17	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.80658213
18	EWS_26573619_Chip-Seq_HEK293_Human	1.76302670
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.73486196
20	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.70665052
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.66302678
22	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.63523036
23	VDR_22108803_ChIP-Seq_LS180_Human	1.62803725
24	DROSHA_22980978_ChIP-Seq_HELA_Human	1.61621254
25	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.60993126
26	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.60940807
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.55117606
28	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.55099711
29	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.52633343
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.50238679
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.49859179
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.47681713
33	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.47598933
34	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.47537836
35	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.43792102
36	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.41705852
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40917567
38	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.38897915
39	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.36391046
40	STAT1_20625510_ChIP-Seq_HELA_Human	1.35685036
41	AHR_22903824_ChIP-Seq_MCF-7_Human	1.35179635
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29629974
43	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.26458482
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.24798766
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.24737669
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23979617
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.23979617
48	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.23266737
49	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.19539692
50	P300_19829295_ChIP-Seq_ESCs_Human	1.19397493
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19146886
52	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.17681084
53	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.17681084
54	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.16358246
55	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.14878486
56	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.13938282
57	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.12875471
58	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.08933525
59	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.08162130
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.07635766
61	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.06477966
62	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.05871021
63	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.04959284
64	OCT4_20526341_ChIP-Seq_ESCs_Human	1.03609563
65	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03576688
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03576688
67	ERA_21632823_ChIP-Seq_H3396_Human	1.02775822
68	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.01901604
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01839563
70	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01004903
71	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.00268977
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00056599
73	BCAT_22108803_ChIP-Seq_LS180_Human	0.99873694
74	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.99660300
75	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.99610376
76	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.97909698
77	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.97582737
78	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.95626532
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.94398230
80	SOX2_21211035_ChIP-Seq_LN229_Human	0.94383234
81	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93577888
82	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.92939211
83	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92813796
84	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.92087340
85	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.90939544
86	TCF4_23295773_ChIP-Seq_U87_Human	0.90300480
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.89234504
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.88503279
89	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.88184191
90	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.87750353
91	CIITA_25753668_ChIP-Seq_RAJI_Human	0.87374543
92	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.87343415
93	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.87314737
94	TAF2_19829295_ChIP-Seq_ESCs_Human	0.87152558
95	NCOR_22424771_ChIP-Seq_293T_Human	0.87046858
96	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.86766716
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.86602101
98	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.85569146
99	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.85285143
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.85276701

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003315_abnormal_perineum_morphology	6.36733303
2	MP0008995_early_reproductive_senescence	4.94142576
3	MP0005187_abnormal_penis_morphology	3.99269939
4	MP0003183_abnormal_peptide_metabolism	3.85035181
5	MP0002102_abnormal_ear_morphology	2.88204966
6	MP0002163_abnormal_gland_morphology	2.88076585
7	MP0005670_abnormal_white_adipose	2.83344916
8	MP0000569_abnormal_digit_pigmentation	2.73551067
9	MP0005379_endocrine/exocrine_gland_phen	2.43229644
10	MP0003724_increased_susceptibility_to	2.31986884
11	MP0005646_abnormal_pituitary_gland	2.20224771
12	MP0000647_abnormal_sebaceous_gland	2.11256467
13	MP0000049_abnormal_middle_ear	2.08966597
14	MP0005551_abnormal_eye_electrophysiolog	1.98458385
15	MP0001968_abnormal_touch/_nociception	1.94778689
16	MP0001485_abnormal_pinna_reflex	1.83124440
17	MP0002653_abnormal_ependyma_morphology	1.81459234
18	MP0001324_abnormal_eye_pigmentation	1.79691586
19	MP0002733_abnormal_thermal_nociception	1.73773502
20	MP0000537_abnormal_urethra_morphology	1.72127445
21	MP0002160_abnormal_reproductive_system	1.70188985
22	MP0005174_abnormal_tail_pigmentation	1.65630522
23	MP0000013_abnormal_adipose_tissue	1.63951032
24	MP0002734_abnormal_mechanical_nocicepti	1.57990671
25	MP0004130_abnormal_muscle_cell	1.48675583
26	MP0003011_delayed_dark_adaptation	1.47099663
27	MP0000778_abnormal_nervous_system	1.41981416
28	MP0005195_abnormal_posterior_eye	1.38869733
29	MP0009745_abnormal_behavioral_response	1.37309752
30	MP0000015_abnormal_ear_pigmentation	1.33845879
31	MP0003638_abnormal_response/metabolism_	1.32608449
32	MP0003567_abnormal_fetal_cardiomyocyte	1.32532542
33	MP0006276_abnormal_autonomic_nervous	1.30484580
34	MP0002138_abnormal_hepatobiliary_system	1.29614182
35	MP0002090_abnormal_vision	1.29212384
36	MP0004270_analgesia	1.28143318
37	MP0001905_abnormal_dopamine_level	1.24871568
38	MP0005253_abnormal_eye_physiology	1.24708085
39	MP0006292_abnormal_olfactory_placode	1.20383772
40	MP0000613_abnormal_salivary_gland	1.19687467
41	MP0002638_abnormal_pupillary_reflex	1.19491882
42	MP0004185_abnormal_adipocyte_glucose	1.19115122
43	MP0008872_abnormal_physiological_respon	1.18136506
44	MP0005423_abnormal_somatic_nervous	1.18109648
45	MP0003186_abnormal_redox_activity	1.16147911
46	MP0000516_abnormal_urinary_system	1.13299140
47	MP0005367_renal/urinary_system_phenotyp	1.13299140
48	MP0009115_abnormal_fat_cell	1.13116849
49	MP0003879_abnormal_hair_cell	1.09417163
50	MP0001661_extended_life_span	1.08543699
51	MP0001986_abnormal_taste_sensitivity	1.08374350
52	MP0009046_muscle_twitch	1.05526867
53	MP0001970_abnormal_pain_threshold	1.05453619
54	MP0003786_premature_aging	1.05234101
55	MP0000631_abnormal_neuroendocrine_gland	0.99904551
56	MP0002751_abnormal_autonomic_nervous	0.99362715
57	MP0005389_reproductive_system_phenotype	0.99327686
58	MP0005220_abnormal_exocrine_pancreas	0.96933219
59	MP0009379_abnormal_foot_pigmentation	0.96608725
60	MP0009053_abnormal_anal_canal	0.95850661
61	MP0003937_abnormal_limbs/digits/tail_de	0.93084365
62	MP0002752_abnormal_somatic_nervous	0.92604242
63	MP0008961_abnormal_basal_metabolism	0.91956778
64	MP0002063_abnormal_learning/memory/cond	0.90389588
65	MP0003880_abnormal_central_pattern	0.86964016
66	MP0002272_abnormal_nervous_system	0.86790638
67	MP0001529_abnormal_vocalization	0.85715853
68	MP0001963_abnormal_hearing_physiology	0.84533392
69	MP0002557_abnormal_social/conspecific_i	0.84021576
70	MP0003938_abnormal_ear_development	0.83594599
71	MP0004142_abnormal_muscle_tone	0.82819863
72	MP0002735_abnormal_chemical_nociception	0.81812251
73	MP0004145_abnormal_muscle_electrophysio	0.81712242
74	MP0009764_decreased_sensitivity_to	0.81508115
75	MP0002095_abnormal_skin_pigmentation	0.81203945
76	MP0009765_abnormal_xenobiotic_induced	0.80752844
77	MP0002089_abnormal_postnatal_growth/wei	0.79937174
78	MP0002277_abnormal_respiratory_mucosa	0.79350230
79	MP0002736_abnormal_nociception_after	0.79060258
80	MP0005310_abnormal_salivary_gland	0.77248623
81	MP0006035_abnormal_mitochondrial_morpho	0.75837066
82	MP0002067_abnormal_sensory_capabilities	0.74717560
83	MP0002909_abnormal_adrenal_gland	0.72693094
84	MP0008789_abnormal_olfactory_epithelium	0.72014907
85	MP0003959_abnormal_lean_body	0.70936498
86	MP0001919_abnormal_reproductive_system	0.70587819
87	MP0002152_abnormal_brain_morphology	0.69289300
88	MP0005075_abnormal_melanosome_morpholog	0.69056381
89	MP0002882_abnormal_neuron_morphology	0.68996362
90	MP0002938_white_spotting	0.67906331
91	MP0002971_abnormal_brown_adipose	0.67205336
92	MP0002177_abnormal_outer_ear	0.65134360
93	MP0002572_abnormal_emotion/affect_behav	0.64734223
94	MP0003787_abnormal_imprinting	0.64609811
95	MP0004924_abnormal_behavior	0.63871372
96	MP0005386_behavior/neurological_phenoty	0.63871372
97	MP0005084_abnormal_gallbladder_morpholo	0.63726559
98	MP0003172_abnormal_lysosome_physiology	0.63520366
99	MP0002184_abnormal_innervation	0.62821538
100	MP0003119_abnormal_digestive_system	0.62814932

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Carpal bone hypoplasia (HP:0001498)	6.31787962
2	Short 1st metacarpal (HP:0010034)	4.92412526
3	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	4.92412526
4	Pancreatic fibrosis (HP:0100732)	4.62370386
5	Abnormality of the 1st metacarpal (HP:0010009)	4.37291504
6	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	4.10612538
7	True hermaphroditism (HP:0010459)	4.00435815
8	Pancreatic cysts (HP:0001737)	3.84801332
9	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.40121647
10	Abnormal respiratory epithelium morphology (HP:0012253)	3.37730462
11	Abnormal respiratory motile cilium morphology (HP:0005938)	3.37730462
12	J-shaped sella turcica (HP:0002680)	3.34676729
13	Gonadotropin excess (HP:0000837)	3.34456414
14	Abolished electroretinogram (ERG) (HP:0000550)	3.30742732
15	Vacuolated lymphocytes (HP:0001922)	3.18740350
16	Abnormality of the odontoid process (HP:0003310)	3.18464427
17	Short phalanx of the thumb (HP:0009660)	3.14828389
18	Progressive cerebellar ataxia (HP:0002073)	3.10521538
19	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.95142231
20	Stenosis of the external auditory canal (HP:0000402)	2.88858821
21	Hypoplasia of the odontoid process (HP:0003311)	2.88269428
22	Fused cervical vertebrae (HP:0002949)	2.83595705
23	Pendular nystagmus (HP:0012043)	2.82090534
24	Increased cerebral lipofuscin (HP:0011813)	2.81845933
25	Morphological abnormality of the middle ear (HP:0008609)	2.79802786
26	Abnormal ciliary motility (HP:0012262)	2.71586947
27	Cystic liver disease (HP:0006706)	2.63574189
28	Tinnitus (HP:0000360)	2.63003372
29	Concave nail (HP:0001598)	2.61462119
30	Hypoalphalipoproteinemia (HP:0003233)	2.56796162
31	Elevated erythrocyte sedimentation rate (HP:0003565)	2.56581151
32	Cone-rod dystrophy (HP:0000548)	2.53764880
33	Abnormality of alanine metabolism (HP:0010916)	2.50933666
34	Hyperalaninemia (HP:0003348)	2.50933666
35	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.50933666
36	Abnormality of liposaccharide metabolism (HP:0010968)	2.48391030
37	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.48391030
38	Abnormality of glycolipid metabolism (HP:0010969)	2.48391030
39	Bony spicule pigmentary retinopathy (HP:0007737)	2.45953862
40	Morphological abnormality of the inner ear (HP:0011390)	2.38025924
41	Shawl scrotum (HP:0000049)	2.34606268
42	Anencephaly (HP:0002323)	2.33694923
43	Long nose (HP:0003189)	2.32648292
44	Optic disc pallor (HP:0000543)	2.31617888
45	Genetic anticipation (HP:0003743)	2.31519180
46	Anomalous pulmonary venous return (HP:0010772)	2.30721071
47	Decreased subcutaneous fat (HP:0001002)	2.30593144
48	Constricted visual fields (HP:0001133)	2.30398736
49	Deformed sella turcica (HP:0002681)	2.28753947
50	Increased purine levels (HP:0004368)	2.26498377
51	Hyperuricemia (HP:0002149)	2.26498377
52	Optic nerve coloboma (HP:0000588)	2.25569490
53	Tented upper lip vermilion (HP:0010804)	2.24940747
54	Furrowed tongue (HP:0000221)	2.24719259
55	Acute necrotizing encephalopathy (HP:0006965)	2.19841873
56	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.18585361
57	Mesangial abnormality (HP:0001966)	2.17898929
58	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.15224417
59	Increased corneal curvature (HP:0100692)	2.14569424
60	Keratoconus (HP:0000563)	2.14569424
61	Beaking of vertebral bodies (HP:0004568)	2.10739288
62	Chronic hepatic failure (HP:0100626)	2.10144020
63	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.09807785
64	Oral leukoplakia (HP:0002745)	2.09768833
65	Abnormal respiratory motile cilium physiology (HP:0012261)	2.09251090
66	Clumsiness (HP:0002312)	2.07820749
67	Methylmalonic acidemia (HP:0002912)	2.07018107
68	Abnormality of cochlea (HP:0000375)	2.05947143
69	Abnormality of the renal collecting system (HP:0004742)	2.05946207
70	Maternal diabetes (HP:0009800)	2.00601379
71	Dysostosis multiplex (HP:0000943)	1.99439255
72	Vertebral arch anomaly (HP:0008438)	1.98729687
73	Short hallux (HP:0010109)	1.98491810
74	Hyperglycinuria (HP:0003108)	1.97461652
75	Insulin-resistant diabetes mellitus (HP:0000831)	1.97146484
76	Oligomenorrhea (HP:0000876)	1.96667755
77	Absent thumb (HP:0009777)	1.96051458
78	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.95701447
79	Absent/shortened dynein arms (HP:0200106)	1.95701447
80	Wide intermamillary distance (HP:0006610)	1.95251684
81	Abnormality of the lumbar spine (HP:0100712)	1.93827001
82	Abnormality of the pulmonary veins (HP:0011718)	1.92915881
83	Aplasia/hypoplasia of the humerus (HP:0006507)	1.90582313
84	Decreased central vision (HP:0007663)	1.90357109
85	Abnormality of the sella turcica (HP:0002679)	1.89212105
86	Chronic sinusitis (HP:0011109)	1.89054524
87	3-Methylglutaconic aciduria (HP:0003535)	1.88505160
88	Diastasis recti (HP:0001540)	1.86472657
89	Abnormality of midbrain morphology (HP:0002418)	1.85869451
90	Molar tooth sign on MRI (HP:0002419)	1.85869451
91	Abnormality of the upper arm (HP:0001454)	1.83436128
92	Megalocornea (HP:0000485)	1.80611848
93	Male pseudohermaphroditism (HP:0000037)	1.80149262
94	Progressive macrocephaly (HP:0004481)	1.78265357
95	Thoracolumbar scoliosis (HP:0002944)	1.77284471
96	Macroorchidism (HP:0000053)	1.77225180
97	Preaxial hand polydactyly (HP:0001177)	1.77001747
98	Acute encephalopathy (HP:0006846)	1.76891708
99	Spontaneous abortion (HP:0005268)	1.76829905
100	Abnormal mitochondria in muscle tissue (HP:0008316)	1.76715353

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	5.00420058
2	ADRBK2	4.51419972
3	MARK1	3.74561867
4	DYRK3	3.64319183
5	WNK4	3.27586715
6	MAP2K7	2.83435523
7	MAP3K6	2.31876525
8	INSRR	2.22562939
9	VRK2	2.19210931
10	BLK	2.12559689
11	GRK1	2.05434804
12	MAP2K4	2.04515636
13	WEE1	2.02815597
14	MAP3K4	1.92256639
15	FRK	1.87838228
16	PIM2	1.82309270
17	SRPK1	1.67692219
18	NUAK1	1.64508992
19	CDK19	1.61751445
20	DYRK2	1.54622506
21	NME1	1.46697401
22	CDC7	1.46135489
23	CDK9	1.44597634
24	DYRK1B	1.38740156
25	STK39	1.34333028
26	PLK2	1.32975259
27	CLK1	1.29827528
28	ALK	1.23277807
29	VRK1	1.21395806
30	TLK1	1.21107880
31	MAP3K5	1.19553064
32	MKNK1	1.18890431
33	ACVR1B	1.18800232
34	SGK2	1.17243806
35	NEK2	1.14548107
36	MAPK13	1.14145868
37	RPS6KA4	1.13038325
38	ADRBK1	1.04329174
39	BMPR1B	1.03786243
40	DYRK1A	0.96016276
41	GRK6	0.95478380
42	PIM1	0.91729419
43	SGK223	0.91166565
44	SGK494	0.91166565
45	MELK	0.87800147
46	RPS6KA5	0.87563257
47	MKNK2	0.84848344
48	MAP4K1	0.77937941
49	SYK	0.77054695
50	SGK3	0.74935328
51	MAP2K1	0.74873038
52	ERBB2	0.71332574
53	PRKCG	0.70971467
54	IKBKB	0.67037030
55	WNK3	0.66818107
56	AURKB	0.66326795
57	ARAF	0.63834448
58	CDK4	0.61918760
59	TRIB3	0.59892129
60	HIPK2	0.53113918
61	CAMKK1	0.52522279
62	RPS6KA1	0.51353040
63	YES1	0.51168897
64	BTK	0.50679422
65	MAP3K11	0.49673038
66	IKBKE	0.49211198
67	CDK5	0.45637589
68	MAPKAPK5	0.45463917
69	PRKAA2	0.42133260
70	MAP4K2	0.40993785
71	CAMK2B	0.40985593
72	PRKCE	0.40909779
73	WNK1	0.40681314
74	GRK5	0.40292315
75	GRK7	0.39552374
76	MAPK4	0.38897584
77	STK38L	0.37139624
78	STK4	0.36413060
79	AKT2	0.35983876
80	RPS6KA6	0.35449978
81	CHUK	0.35425572
82	IRAK1	0.35168434
83	STK24	0.34583147
84	STK3	0.34416918
85	PIK3CG	0.33792712
86	PRKACB	0.32500767
87	AURKA	0.31660523
88	MAP3K2	0.31636972
89	CDK14	0.29670682
90	OXSR1	0.29558162
91	NEK1	0.28980129
92	MAP2K3	0.28804776
93	LYN	0.26963164
94	ITK	0.26658997
95	PTK2B	0.26564173
96	DAPK3	0.26010238
97	TEC	0.24360863
98	PRKG1	0.23867274
99	RPS6KA3	0.23586799
100	PRKCQ	0.23534788

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	4.27975740
2	Nicotine addiction_Homo sapiens_hsa05033	3.56438763
3	Basal transcription factors_Homo sapiens_hsa03022	3.13752048
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.82824091
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.56785729
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.50517829
7	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.37293136
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.30551166
9	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.29750165
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.28094435
11	Ether lipid metabolism_Homo sapiens_hsa00565	2.16162100
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.13917634
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.13758373
14	Nitrogen metabolism_Homo sapiens_hsa00910	2.05772226
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.96789146
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.89275714
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.87195027
18	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.85470812
19	Morphine addiction_Homo sapiens_hsa05032	1.73554541
20	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.71998720
21	Alcoholism_Homo sapiens_hsa05034	1.61502741
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.58247650
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.55053137
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.52361571
25	Olfactory transduction_Homo sapiens_hsa04740	1.52339419
26	Taste transduction_Homo sapiens_hsa04742	1.51717413
27	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.44605609
28	Ribosome_Homo sapiens_hsa03010	1.39844883
29	Phototransduction_Homo sapiens_hsa04744	1.35368381
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.33012963
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.32042562
32	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.25428161
33	GABAergic synapse_Homo sapiens_hsa04727	1.20287650
34	Glutamatergic synapse_Homo sapiens_hsa04724	1.19640680
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.16171432
36	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.16162444
37	Non-homologous end-joining_Homo sapiens_hsa03450	1.15484025
38	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.00885055
39	Melanoma_Homo sapiens_hsa05218	1.00225534
40	Salivary secretion_Homo sapiens_hsa04970	0.99530562
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.97862914
42	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.91350638
43	Butanoate metabolism_Homo sapiens_hsa00650	0.90144677
44	Fat digestion and absorption_Homo sapiens_hsa04975	0.82077152
45	Calcium signaling pathway_Homo sapiens_hsa04020	0.81984718
46	Homologous recombination_Homo sapiens_hsa03440	0.81877044
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78796349
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.78294310
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.75835937
50	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.70616574
51	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.69199518
52	Sulfur metabolism_Homo sapiens_hsa00920	0.65758454
53	Retinol metabolism_Homo sapiens_hsa00830	0.65646119
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65082347
55	Type II diabetes mellitus_Homo sapiens_hsa04930	0.64077477
56	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.63453120
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60167070
58	Peroxisome_Homo sapiens_hsa04146	0.59864000
59	RNA degradation_Homo sapiens_hsa03018	0.59609734
60	Serotonergic synapse_Homo sapiens_hsa04726	0.56216436
61	One carbon pool by folate_Homo sapiens_hsa00670	0.55313309
62	FoxO signaling pathway_Homo sapiens_hsa04068	0.54442892
63	Long-term depression_Homo sapiens_hsa04730	0.51545080
64	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.51476340
65	Antigen processing and presentation_Homo sapiens_hsa04612	0.50453399
66	MAPK signaling pathway_Homo sapiens_hsa04010	0.50185200
67	Asthma_Homo sapiens_hsa05310	0.48842403
68	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.47115733
69	Estrogen signaling pathway_Homo sapiens_hsa04915	0.45724819
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45100839
71	Circadian entrainment_Homo sapiens_hsa04713	0.44109400
72	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.43773655
73	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.43230313
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41664691
75	Primary immunodeficiency_Homo sapiens_hsa05340	0.40564354
76	Axon guidance_Homo sapiens_hsa04360	0.39046589
77	cAMP signaling pathway_Homo sapiens_hsa04024	0.38342263
78	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.37676448
79	Cholinergic synapse_Homo sapiens_hsa04725	0.36802218
80	Insulin secretion_Homo sapiens_hsa04911	0.36557471
81	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36080403
82	GnRH signaling pathway_Homo sapiens_hsa04912	0.35563870
83	Histidine metabolism_Homo sapiens_hsa00340	0.35028164
84	Renin secretion_Homo sapiens_hsa04924	0.34718658
85	Spliceosome_Homo sapiens_hsa03040	0.34236571
86	Lysosome_Homo sapiens_hsa04142	0.33104153
87	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.32760143
88	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.32320114
89	Ras signaling pathway_Homo sapiens_hsa04014	0.32069319
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31081712
91	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.30985208
92	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.30755197
93	Huntingtons disease_Homo sapiens_hsa05016	0.30296326
94	Type I diabetes mellitus_Homo sapiens_hsa04940	0.28935435
95	Gap junction_Homo sapiens_hsa04540	0.28667328
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.26914967
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.26284295
98	Cocaine addiction_Homo sapiens_hsa05030	0.25945426
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.25067816
100	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.24480103

HNRNPABP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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