HNRNPC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.74261062
2establishment of viral latency (GO:0019043)4.71320193
3DNA strand elongation involved in DNA replication (GO:0006271)4.58712498
4DNA strand elongation (GO:0022616)4.38751043
5DNA unwinding involved in DNA replication (GO:0006268)4.38329505
6DNA ligation (GO:0006266)4.31992133
7DNA replication initiation (GO:0006270)4.29493737
8pore complex assembly (GO:0046931)4.28744582
9telomere maintenance via semi-conservative replication (GO:0032201)4.25484024
10maturation of SSU-rRNA (GO:0030490)4.24275949
11mitotic metaphase plate congression (GO:0007080)4.23572740
12nucleobase biosynthetic process (GO:0046112)4.21245707
13DNA replication checkpoint (GO:0000076)4.17204013
14purine nucleobase biosynthetic process (GO:0009113)4.13590314
15ribosomal small subunit assembly (GO:0000028)4.07540066
16formation of translation preinitiation complex (GO:0001731)4.03311179
17protein localization to kinetochore (GO:0034501)4.02215928
18non-recombinational repair (GO:0000726)4.01832554
19double-strand break repair via nonhomologous end joining (GO:0006303)4.01832554
20sister chromatid segregation (GO:0000819)3.99352222
21CENP-A containing nucleosome assembly (GO:0034080)3.92762510
22DNA topological change (GO:0006265)3.89796118
23telomere maintenance via recombination (GO:0000722)3.88065389
24chromatin remodeling at centromere (GO:0031055)3.85077047
25mitotic chromosome condensation (GO:0007076)3.84181720
26ribosome biogenesis (GO:0042254)3.78979113
27mitotic recombination (GO:0006312)3.76485274
28metaphase plate congression (GO:0051310)3.70859334
29DNA replication-independent nucleosome organization (GO:0034724)3.64852436
30DNA replication-independent nucleosome assembly (GO:0006336)3.64852436
31spliceosomal snRNP assembly (GO:0000387)3.58975381
32ribonucleoprotein complex biogenesis (GO:0022613)3.57740279
33ribosome assembly (GO:0042255)3.57097619
34IMP biosynthetic process (GO:0006188)3.55761969
35DNA replication-dependent nucleosome assembly (GO:0006335)3.55675623
36DNA replication-dependent nucleosome organization (GO:0034723)3.55675623
37telomere maintenance via telomere lengthening (GO:0010833)3.54979330
38mitotic nuclear envelope disassembly (GO:0007077)3.54008703
39negative regulation of mRNA processing (GO:0050686)3.51670772
40L-serine metabolic process (GO:0006563)3.51332398
41kinetochore organization (GO:0051383)3.50067820
42protein localization to chromosome, centromeric region (GO:0071459)3.48992593
43peptidyl-arginine omega-N-methylation (GO:0035247)3.48235306
44mitotic sister chromatid cohesion (GO:0007064)3.48107768
45ribosomal large subunit biogenesis (GO:0042273)3.48084155
46DNA duplex unwinding (GO:0032508)3.45413023
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.44603683
48regulation of translational fidelity (GO:0006450)3.42758541
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39222636
50regulation of helicase activity (GO:0051095)3.38574943
51protein complex localization (GO:0031503)3.38216700
52DNA geometric change (GO:0032392)3.37992921
53proteasome assembly (GO:0043248)3.35990120
54tRNA aminoacylation for protein translation (GO:0006418)3.35016290
55histone exchange (GO:0043486)3.34904499
56establishment of chromosome localization (GO:0051303)3.34704854
57regulation of chromosome segregation (GO:0051983)3.34583140
58attachment of spindle microtubules to kinetochore (GO:0008608)3.32342488
59transcription-coupled nucleotide-excision repair (GO:0006283)3.31483297
60anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.31255282
61viral mRNA export from host cell nucleus (GO:0046784)3.29968383
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29585920
63tRNA aminoacylation (GO:0043039)3.28596675
64amino acid activation (GO:0043038)3.28596675
65nuclear pore organization (GO:0006999)3.27373298
66ribosomal small subunit biogenesis (GO:0042274)3.26895387
67rRNA processing (GO:0006364)3.26775927
68viral transcription (GO:0019083)3.26435515
69nuclear envelope disassembly (GO:0051081)3.26188543
70membrane disassembly (GO:0030397)3.26188543
71histone arginine methylation (GO:0034969)3.24724145
72translational termination (GO:0006415)3.24439921
73kinetochore assembly (GO:0051382)3.24166720
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22771382
75spliceosomal complex assembly (GO:0000245)3.22533318
76regulation of spindle organization (GO:0090224)3.21687100
77regulation of centriole replication (GO:0046599)3.21633244
78regulation of mitotic metaphase/anaphase transition (GO:0030071)3.21418554
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.21418554
80establishment of integrated proviral latency (GO:0075713)3.20932837
81negative regulation of mRNA metabolic process (GO:1903312)3.20868413
82positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20026700
83translational initiation (GO:0006413)3.18786210
84* RNA splicing, via transesterification reactions (GO:0000375)3.17166525
85rRNA metabolic process (GO:0016072)3.16387173
86regulation of mitotic sister chromatid separation (GO:0010965)3.16119744
87regulation of mitotic sister chromatid segregation (GO:0033047)3.16119744
88regulation of sister chromatid segregation (GO:0033045)3.16119744
89* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.15633882
90* mRNA splicing, via spliceosome (GO:0000398)3.15633882
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14753807
92regulation of sister chromatid cohesion (GO:0007063)3.14551630
93mitotic sister chromatid segregation (GO:0000070)3.14387778
94regulation of double-strand break repair via homologous recombination (GO:0010569)3.13921597
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.13609110
967-methylguanosine mRNA capping (GO:0006370)3.11047501
97positive regulation of chromosome segregation (GO:0051984)3.10942942
98spindle checkpoint (GO:0031577)3.07582619
99RNA capping (GO:0036260)3.06928936
1007-methylguanosine RNA capping (GO:0009452)3.06928936
101rRNA modification (GO:0000154)3.06354500
102IMP metabolic process (GO:0046040)3.05693984
103folic acid-containing compound biosynthetic process (GO:0009396)3.05290915
104histone H2A acetylation (GO:0043968)3.04586569
105regulation of nuclear cell cycle DNA replication (GO:0033262)3.04378450
106cullin deneddylation (GO:0010388)3.03697884
107negative regulation of ligase activity (GO:0051352)3.02083257
108negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02083257
109peptidyl-arginine methylation (GO:0018216)3.01304666
110peptidyl-arginine N-methylation (GO:0035246)3.01304666
111transcription elongation from RNA polymerase III promoter (GO:0006385)3.01190357
112termination of RNA polymerase III transcription (GO:0006386)3.01190357
113maturation of 5.8S rRNA (GO:0000460)3.00888093
114cell cycle G1/S phase transition (GO:0044843)3.00741694
115G1/S transition of mitotic cell cycle (GO:0000082)3.00741694
116DNA damage response, detection of DNA damage (GO:0042769)3.00682123
117translational elongation (GO:0006414)3.00271977
118negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00085868
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00085868
120negative regulation of sister chromatid segregation (GO:0033046)3.00085868
121negative regulation of mitotic sister chromatid separation (GO:2000816)3.00085868
122negative regulation of chromosome segregation (GO:0051985)2.99871958
123spliceosomal tri-snRNP complex assembly (GO:0000244)2.99795312
124base-excision repair (GO:0006284)2.97782773
125DNA conformation change (GO:0071103)2.97240891
126mitotic spindle checkpoint (GO:0071174)2.96920111
127spindle assembly checkpoint (GO:0071173)2.96555635
128somatic hypermutation of immunoglobulin genes (GO:0016446)2.96511430
129somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96511430
130negative regulation of RNA splicing (GO:0033119)2.95865556
131termination of RNA polymerase II transcription (GO:0006369)2.95429574
132mitotic spindle assembly checkpoint (GO:0007094)2.95360217
133nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.92485234
134transcription elongation from RNA polymerase I promoter (GO:0006362)2.92397516
135negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91002236
136* ATP-dependent chromatin remodeling (GO:0043044)2.90861022
137DNA deamination (GO:0045006)2.90535324
138termination of RNA polymerase I transcription (GO:0006363)2.90323617

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.77607211
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.45620247
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82832927
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.78809688
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42822956
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.41408399
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.28367757
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24978147
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.16807646
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.09508567
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97440319
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.94046263
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89264139
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88849747
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84287987
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71514238
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.51279822
18* XRN2_22483619_ChIP-Seq_HELA_Human2.50491410
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.47524184
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35965739
21* VDR_23849224_ChIP-Seq_CD4+_Human2.32856151
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.29350855
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20704495
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16541626
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10897371
26AR_21909140_ChIP-Seq_LNCAP_Human2.09116434
27FOXP3_21729870_ChIP-Seq_TREG_Human2.07379292
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05496781
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03735400
30TTF2_22483619_ChIP-Seq_HELA_Human2.01817474
31DCP1A_22483619_ChIP-Seq_HELA_Human1.99512326
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98510199
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.94619067
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94045555
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93419089
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.92733767
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92606147
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88115085
39* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87950853
40* GABP_19822575_ChIP-Seq_HepG2_Human1.87852494
41ELK1_19687146_ChIP-ChIP_HELA_Human1.85825847
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82969963
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.80731139
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75449170
45CIITA_25753668_ChIP-Seq_RAJI_Human1.73212499
46* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67418423
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63598341
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.63320930
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56431555
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54118445
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52933086
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51937715
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47700652
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47181258
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46734369
56KDM5A_27292631_Chip-Seq_BREAST_Human1.46172939
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45223269
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42545678
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41865213
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41771303
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.38672245
62MYC_22102868_ChIP-Seq_BL_Human1.36179269
63* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31803073
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29431981
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28347732
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23976075
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22225688
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18406283
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16654480
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14834801
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14556198
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14263314
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.11751311
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11286905
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10095754
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09475405
77TFEB_21752829_ChIP-Seq_HELA_Human1.06965812
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06747621
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.06612819
80MYC_18940864_ChIP-ChIP_HL60_Human1.05933887
81SOX17_20123909_ChIP-Seq_XEN_Mouse1.05644061
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04880808
83* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03392760
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02660481
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.01636453
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01048376
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98946207
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98946207
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98946207
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.98943001
91* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98351903
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.97593750
93TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97398276
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94755005
95NANOG_21062744_ChIP-ChIP_HESCs_Human0.94386470
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92805910
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92074629
98* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90877683
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90830052
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90811064
101NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90613381
102NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88393947
103NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88142142
104CHD1_26751641_Chip-Seq_LNCaP_Human0.88078195
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86192724
106TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85910895
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85348207
108POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83184594
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82609006
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82548318
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77434499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.02787815
2MP0010094_abnormal_chromosome_stability4.50797685
3MP0004957_abnormal_blastocyst_morpholog4.27464285
4MP0003111_abnormal_nucleus_morphology4.18411814
5MP0003077_abnormal_cell_cycle3.90772017
6MP0008057_abnormal_DNA_replication3.74534442
7MP0008058_abnormal_DNA_repair3.43088543
8MP0008007_abnormal_cellular_replicative3.18231240
9MP0003123_paternal_imprinting2.90768432
10MP0008932_abnormal_embryonic_tissue2.86063480
11MP0008877_abnormal_DNA_methylation2.32326769
12MP0000350_abnormal_cell_proliferation2.28613820
13* MP0001730_embryonic_growth_arrest2.18449151
14MP0009697_abnormal_copulation2.13750613
15MP0006292_abnormal_olfactory_placode2.00914336
16MP0003786_premature_aging1.99780205
17MP0010030_abnormal_orbit_morphology1.98563562
18MP0003121_genomic_imprinting1.96375397
19MP0002396_abnormal_hematopoietic_system1.95229618
20MP0001697_abnormal_embryo_size1.71118278
21MP0001672_abnormal_embryogenesis/_devel1.70913826
22MP0005380_embryogenesis_phenotype1.70913826
23MP0003315_abnormal_perineum_morphology1.70898281
24MP0003718_maternal_effect1.64682728
25MP0002653_abnormal_ependyma_morphology1.63301549
26MP0002085_abnormal_embryonic_tissue1.62303410
27MP0003984_embryonic_growth_retardation1.52212159
28* MP0002080_prenatal_lethality1.52177306
29MP0000537_abnormal_urethra_morphology1.51361623
30MP0006035_abnormal_mitochondrial_morpho1.50904489
31MP0002697_abnormal_eye_size1.49284541
32MP0002088_abnormal_embryonic_growth/wei1.49076617
33MP0003890_abnormal_embryonic-extraembry1.45690846
34MP0000490_abnormal_crypts_of1.43743404
35* MP0002084_abnormal_developmental_patter1.42212907
36MP0003567_abnormal_fetal_cardiomyocyte1.41821099
37MP0001293_anophthalmia1.40604982
38MP0010352_gastrointestinal_tract_polyps1.39300568
39MP0000313_abnormal_cell_death1.38934529
40MP0004197_abnormal_fetal_growth/weight/1.37536031
41MP0008789_abnormal_olfactory_epithelium1.36284953
42MP0002009_preneoplasia1.33172259
43MP0003119_abnormal_digestive_system1.29235741
44MP0002210_abnormal_sex_determination1.22771344
45MP0002938_white_spotting1.22564539
46MP0002086_abnormal_extraembryonic_tissu1.22527999
47MP0009053_abnormal_anal_canal1.20963998
48MP0009333_abnormal_splenocyte_physiolog1.17906521
49MP0002019_abnormal_tumor_incidence1.16881255
50MP0004808_abnormal_hematopoietic_stem1.16066346
51MP0003941_abnormal_skin_development1.13998651
52MP0010307_abnormal_tumor_latency1.13656153
53MP0004133_heterotaxia1.10699252
54MP0003937_abnormal_limbs/digits/tail_de1.09369606
55MP0001346_abnormal_lacrimal_gland1.08524949
56MP0008995_early_reproductive_senescence1.06564223
57MP0001286_abnormal_eye_development1.02934724
58MP0002160_abnormal_reproductive_system1.02055875
59MP0001529_abnormal_vocalization1.01825332
60MP0000566_synostosis1.01570898
61MP0001145_abnormal_male_reproductive1.01325305
62MP0006054_spinal_hemorrhage1.01060244
63MP0002233_abnormal_nose_morphology1.00567109
64MP0003763_abnormal_thymus_physiology0.99921365
65MP0000703_abnormal_thymus_morphology0.97534231
66MP0002111_abnormal_tail_morphology0.95951145
67MP0006072_abnormal_retinal_apoptosis0.95169763
68MP0000049_abnormal_middle_ear0.94947156
69MP0005394_taste/olfaction_phenotype0.94048126
70MP0005499_abnormal_olfactory_system0.94048126
71MP0009672_abnormal_birth_weight0.92867054
72MP0002751_abnormal_autonomic_nervous0.91699736
73MP0000647_abnormal_sebaceous_gland0.90710599
74MP0001727_abnormal_embryo_implantation0.89269835
75MP0002877_abnormal_melanocyte_morpholog0.88786920
76MP0000653_abnormal_sex_gland0.88409287
77MP0003787_abnormal_imprinting0.87362267
78MP0003938_abnormal_ear_development0.87091871
79MP0001119_abnormal_female_reproductive0.85794229
80MP0005501_abnormal_skin_physiology0.84435046
81MP0003122_maternal_imprinting0.83882068
82MP0001929_abnormal_gametogenesis0.83580652
83MP0002398_abnormal_bone_marrow0.82600529
84MP0000516_abnormal_urinary_system0.82398482
85MP0005367_renal/urinary_system_phenotyp0.82398482
86MP0002163_abnormal_gland_morphology0.81505650
87MP0002102_abnormal_ear_morphology0.81127140
88MP0005076_abnormal_cell_differentiation0.79061195
89MP0000428_abnormal_craniofacial_morphol0.78689812
90MP0003861_abnormal_nervous_system0.78653423
91MP0004233_abnormal_muscle_weight0.78458650
92MP0005389_reproductive_system_phenotype0.76920854
93MP0002722_abnormal_immune_system0.75515299
94MP0009379_abnormal_foot_pigmentation0.74448905
95MP0003385_abnormal_body_wall0.73103425
96MP0005391_vision/eye_phenotype0.72066750
97MP0000858_altered_metastatic_potential0.71785025
98MP0005384_cellular_phenotype0.71271987
99MP0009703_decreased_birth_body0.71017842
100MP0001188_hyperpigmentation0.70783312
101MP0003755_abnormal_palate_morphology0.70758393
102MP0002254_reproductive_system_inflammat0.70625885
103MP0000689_abnormal_spleen_morphology0.69060647
104MP0002132_abnormal_respiratory_system0.68869874
105MP0002092_abnormal_eye_morphology0.67901800
106MP0003186_abnormal_redox_activity0.67083101
107MP0001915_intracranial_hemorrhage0.66821024
108MP0010234_abnormal_vibrissa_follicle0.66638288
109MP0003221_abnormal_cardiomyocyte_apopto0.64299446
110MP0002095_abnormal_skin_pigmentation0.64293982
111MP0005187_abnormal_penis_morphology0.63926914
112MP0003136_yellow_coat_color0.63455430
113MP0002114_abnormal_axial_skeleton0.62102045
114MP0002429_abnormal_blood_cell0.62084841
115MP0004264_abnormal_extraembryonic_tissu0.61554474
116MP0001545_abnormal_hematopoietic_system0.61524531
117MP0005397_hematopoietic_system_phenotyp0.61524531
118MP0005621_abnormal_cell_physiology0.61498459
119MP0000432_abnormal_head_morphology0.60700672
120MP0003942_abnormal_urinary_system0.60377833
121MP0002090_abnormal_vision0.60198261
122MP0003115_abnormal_respiratory_system0.59649878
123MP0003943_abnormal_hepatobiliary_system0.59386959
124MP0000358_abnormal_cell_content/0.59354354
125MP0004147_increased_porphyrin_level0.59279091
126MP0003935_abnormal_craniofacial_develop0.58596226
127MP0002081_perinatal_lethality0.57938511
128MP0006036_abnormal_mitochondrial_physio0.57858607

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.92971860
2Cortical dysplasia (HP:0002539)4.06325454
3Abnormality of the anterior horn cell (HP:0006802)3.95786469
4Degeneration of anterior horn cells (HP:0002398)3.95786469
5Breast hypoplasia (HP:0003187)3.81892570
6Reticulocytopenia (HP:0001896)3.64050207
7Patellar aplasia (HP:0006443)3.62646722
8Colon cancer (HP:0003003)3.56204640
9Aplasia/Hypoplasia of the patella (HP:0006498)3.53046306
10Microvesicular hepatic steatosis (HP:0001414)3.39848015
11Spastic diplegia (HP:0001264)3.34044608
12Chromsome breakage (HP:0040012)3.25603125
13Medulloblastoma (HP:0002885)3.23294977
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19676527
15Cerebral hypomyelination (HP:0006808)3.11582632
16Oral leukoplakia (HP:0002745)3.11155039
17Carpal bone hypoplasia (HP:0001498)3.08362395
18Multiple enchondromatosis (HP:0005701)3.04965532
19Abnormality of the labia minora (HP:0012880)3.02559726
20Meckel diverticulum (HP:0002245)2.98620073
21Aplastic anemia (HP:0001915)2.91964334
22Selective tooth agenesis (HP:0001592)2.88227583
23Abnormality of the ileum (HP:0001549)2.84819039
24Abnormality of cells of the erythroid lineage (HP:0012130)2.83016317
25Absent radius (HP:0003974)2.82309621
26Rough bone trabeculation (HP:0100670)2.77976318
27Abnormality of the preputium (HP:0100587)2.77512346
28Abnormal number of erythroid precursors (HP:0012131)2.69035147
29Aplasia involving forearm bones (HP:0009822)2.67135617
30Absent forearm bone (HP:0003953)2.67135617
31Abnormal lung lobation (HP:0002101)2.66649809
32Abnormal number of incisors (HP:0011064)2.66055077
33Abnormality of chromosome stability (HP:0003220)2.63593988
34Ependymoma (HP:0002888)2.58954528
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.56376313
36Absent thumb (HP:0009777)2.55322727
37Agnosia (HP:0010524)2.51800884
38Impulsivity (HP:0100710)2.51726129
39Horseshoe kidney (HP:0000085)2.51542164
40Supernumerary spleens (HP:0009799)2.49787200
41Duodenal stenosis (HP:0100867)2.43478596
42Small intestinal stenosis (HP:0012848)2.43478596
43Ectopic kidney (HP:0000086)2.42988639
44Atrophy/Degeneration involving motor neurons (HP:0007373)2.38790396
45Optic nerve coloboma (HP:0000588)2.37881654
46Myelodysplasia (HP:0002863)2.37340768
47Premature graying of hair (HP:0002216)2.36448527
48Progressive external ophthalmoplegia (HP:0000590)2.36288202
49Neoplasm of the pancreas (HP:0002894)2.30211082
50Volvulus (HP:0002580)2.25002334
51Triphalangeal thumb (HP:0001199)2.24104417
5211 pairs of ribs (HP:0000878)2.22223942
53Macrocytic anemia (HP:0001972)2.21977627
54Atresia of the external auditory canal (HP:0000413)2.21611052
55Rhabdomyosarcoma (HP:0002859)2.20628282
56Bone marrow hypocellularity (HP:0005528)2.20541170
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19238411
58Microretrognathia (HP:0000308)2.14624384
59Tracheoesophageal fistula (HP:0002575)2.13692068
60Sloping forehead (HP:0000340)2.11083151
61Cleft eyelid (HP:0000625)2.10137089
62Stenosis of the external auditory canal (HP:0000402)2.10054354
63Abnormality of the duodenum (HP:0002246)2.08160690
64Abnormal trabecular bone morphology (HP:0100671)2.07384164
65Trismus (HP:0000211)2.05736930
66Pallor (HP:0000980)2.01561416
67Cellular immunodeficiency (HP:0005374)1.99831132
68Aplasia/Hypoplasia of the sternum (HP:0006714)1.98882875
69Nephroblastoma (Wilms tumor) (HP:0002667)1.98810261
70Pelvic girdle muscle weakness (HP:0003749)1.98307422
71Proximal placement of thumb (HP:0009623)1.97080753
72Abnormality of methionine metabolism (HP:0010901)1.94285612
73Progressive muscle weakness (HP:0003323)1.93756345
74Neuroblastoma (HP:0003006)1.93010398
75Primitive neuroectodermal tumor (HP:0030065)1.93010398
76Neuroblastic tumors (HP:0004376)1.93010398
77Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.93010398
78Short thumb (HP:0009778)1.92567973
79Basal cell carcinoma (HP:0002671)1.91017323
80Deviation of the thumb (HP:0009603)1.90148970
81Embryonal neoplasm (HP:0002898)1.90102846
82Amaurosis fugax (HP:0100576)1.90041470
83Embryonal renal neoplasm (HP:0011794)1.89940513
84Increased nuchal translucency (HP:0010880)1.88478981
85Choanal atresia (HP:0000453)1.87547147
86Increased serum pyruvate (HP:0003542)1.86028836
87Abnormality of glycolysis (HP:0004366)1.86028836
88Cholecystitis (HP:0001082)1.86011489
89Abnormal gallbladder physiology (HP:0012438)1.86011489
90Cafe-au-lait spot (HP:0000957)1.83808581
91Hypoplasia of the radius (HP:0002984)1.83333870
92Abnormality of the carotid arteries (HP:0005344)1.82086403
93Secondary amenorrhea (HP:0000869)1.82008797
94Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80314692
95Lymphoma (HP:0002665)1.78654121
96Abnormality of the musculature of the pelvis (HP:0001469)1.77851250
97Abnormality of the hip-girdle musculature (HP:0001445)1.77851250
98Glossoptosis (HP:0000162)1.77721862
99Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77196599
100CNS hypomyelination (HP:0003429)1.76804729
101Squamous cell carcinoma (HP:0002860)1.75195183
102Glioma (HP:0009733)1.74962155
103Duplicated collecting system (HP:0000081)1.71986694
104Neoplasm of the colon (HP:0100273)1.71126399
105Facial cleft (HP:0002006)1.70948308
106Neoplasm of the adrenal gland (HP:0100631)1.70872574
107Nervous tissue neoplasm (HP:0030060)1.68808622
108Neuroectodermal neoplasm (HP:0030061)1.68808622
109Neuroepithelial neoplasm (HP:0030063)1.68808622
110Ovarian neoplasm (HP:0100615)1.68423618
111Deep philtrum (HP:0002002)1.67289456
112Hepatoblastoma (HP:0002884)1.67152366
113Breast aplasia (HP:0100783)1.66746529
114Missing ribs (HP:0000921)1.66538901
115Type I transferrin isoform profile (HP:0003642)1.66257221
116IgM deficiency (HP:0002850)1.65844874
117Hypoplastic pelvis (HP:0008839)1.65086981
118Slender long bone (HP:0003100)1.64873916
119High anterior hairline (HP:0009890)1.64725805
120Postnatal microcephaly (HP:0005484)1.63060360
121Short 4th metacarpal (HP:0010044)1.62873978
122Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.62873978
123Abnormality of cochlea (HP:0000375)1.61345378
124Shoulder girdle muscle weakness (HP:0003547)1.61214975
125Aplasia/Hypoplasia of the breasts (HP:0010311)1.61125963
126Premature ovarian failure (HP:0008209)1.60770838
127Irregular epiphyses (HP:0010582)1.60548425
128Overlapping toe (HP:0001845)1.59828234
129Increased hepatocellular lipid droplets (HP:0006565)1.59428134
130Hyperglycinemia (HP:0002154)1.59286393
131Astrocytoma (HP:0009592)1.59128225
132Abnormality of the astrocytes (HP:0100707)1.59128225
133Malignant gastrointestinal tract tumors (HP:0006749)1.58010981
134Gastrointestinal carcinoma (HP:0002672)1.58010981
135Insidious onset (HP:0003587)1.57886665
136Termporal pattern (HP:0011008)1.57886665
137Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.57794509
138Abnormal protein N-linked glycosylation (HP:0012347)1.57794509
139Abnormal protein glycosylation (HP:0012346)1.57794509
140Abnormal glycosylation (HP:0012345)1.57794509
141Neoplasm of striated muscle (HP:0009728)1.57215547
142Homocystinuria (HP:0002156)1.56487931
143Abnormality of homocysteine metabolism (HP:0010919)1.56487931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.71569631
2EIF2AK14.34742855
3WEE14.17144218
4CDC73.90867090
5SRPK13.49429916
6TSSK63.08394850
7MKNK12.97804021
8VRK22.71809317
9MKNK22.23299725
10PLK42.22544868
11PASK2.20921021
12BRSK22.20829406
13EIF2AK32.12030986
14NEK22.10823688
15PLK32.10663129
16STK162.00446991
17PLK11.97736082
18ACVR1B1.96959516
19TTK1.90890789
20VRK11.90067268
21TRIM281.87599195
22TESK21.84114860
23NEK11.73127421
24CDK71.59080990
25ATR1.58714213
26DYRK31.57720553
27AURKB1.52125492
28BRSK11.51506473
29TAF11.45177145
30SMG11.41987468
31RPS6KA41.41827816
32CCNB11.40287620
33TGFBR11.39114327
34RPS6KB21.35698870
35NME21.29541462
36CHEK21.29061886
37CHEK11.24865736
38AURKA1.23516546
39PNCK1.18972905
40TLK11.06603205
41CDK81.06471199
42EIF2AK21.05840240
43NUAK11.03774299
44LIMK11.03613076
45CDK121.02377382
46PAK41.01259311
47EPHA20.99968805
48CSNK1A1L0.98552803
49CDK40.97460988
50MAP3K80.89952912
51CSNK1G10.88841333
52DYRK20.87121347
53BRD40.86088688
54CDK20.85586108
55ATM0.83980058
56STK40.83284877
57ALK0.83024182
58TESK10.77173606
59CLK10.76727430
60ERBB40.75311063
61* CSNK2A10.74427930
62ERBB30.72630128
63* CSNK2A20.71652644
64SCYL20.68835731
65ZAK0.68654717
66CDK10.68432985
67MAP3K40.68414698
68PIM20.67580504
69LATS10.66780416
70STK100.65694652
71PBK0.65674481
72BCR0.63928271
73MAP2K70.63702584
74MELK0.63501544
75YES10.63242384
76PIM10.63240010
77CSNK1G20.61775211
78AKT30.60339292
79PAK10.59379761
80CDK90.57434196
81BCKDK0.56659491
82FGFR10.56003703
83RPS6KA50.50629006
84STK38L0.50576591
85NEK90.48092029
86CDK60.47222540
87DAPK10.46774535
88PRKCI0.45440253
89WNK30.45148939
90BRAF0.42754165
91MST40.42485946
92IRAK40.41688039
93CDK150.41030549
94STK30.39961284
95CSNK1E0.39486093
96EEF2K0.39276861
97PDK20.38322500
98STK240.37936840
99SIK30.35428095
100NME10.35278501
101LATS20.34598459
102KSR10.34489982
103PRKDC0.34476204
104CSNK1G30.33843996
105PLK20.32703034
106TNIK0.32153049
107MAP3K100.31193214
108RAF10.30484991
109CDK30.29211958
110ICK0.27607944
111KDR0.27394005
112MAPK140.26930681
113BLK0.23702849
114CHUK0.23185279
115LRRK20.23115050
116BTK0.22562108
117ILK0.22418668
118MAPKAPK20.21738296
119CDK140.21268083
120AKT10.20381506
121TXK0.20144033
122CDK11A0.19384556
123CDK180.19312447
124AKT20.17973696
125CDK190.17858838

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.66505136
2Mismatch repair_Homo sapiens_hsa034304.13920684
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.66299189
4* Spliceosome_Homo sapiens_hsa030403.64460181
5Proteasome_Homo sapiens_hsa030503.63602527
6RNA polymerase_Homo sapiens_hsa030203.52189374
7Ribosome_Homo sapiens_hsa030103.24793709
8RNA transport_Homo sapiens_hsa030133.17289519
9Homologous recombination_Homo sapiens_hsa034403.06803923
10Base excision repair_Homo sapiens_hsa034103.03282644
11Nucleotide excision repair_Homo sapiens_hsa034202.92646074
12Cell cycle_Homo sapiens_hsa041102.75589742
13One carbon pool by folate_Homo sapiens_hsa006702.41145411
14Pyrimidine metabolism_Homo sapiens_hsa002402.40028752
15Basal transcription factors_Homo sapiens_hsa030222.36264214
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33520163
17Fanconi anemia pathway_Homo sapiens_hsa034602.18993605
18Non-homologous end-joining_Homo sapiens_hsa034502.11153054
19RNA degradation_Homo sapiens_hsa030182.04220876
20mRNA surveillance pathway_Homo sapiens_hsa030152.02587994
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81050643
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65883724
23p53 signaling pathway_Homo sapiens_hsa041151.54380471
24Epstein-Barr virus infection_Homo sapiens_hsa051691.38982443
25Purine metabolism_Homo sapiens_hsa002301.33072123
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32764287
27Steroid biosynthesis_Homo sapiens_hsa001001.25457761
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17529015
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17515329
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15526760
31Pyruvate metabolism_Homo sapiens_hsa006201.12433408
32Fatty acid elongation_Homo sapiens_hsa000621.09644423
33Oocyte meiosis_Homo sapiens_hsa041141.07289021
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05038804
35Herpes simplex infection_Homo sapiens_hsa051681.04141490
36Protein export_Homo sapiens_hsa030601.00122438
37Propanoate metabolism_Homo sapiens_hsa006400.98793077
38Antigen processing and presentation_Homo sapiens_hsa046120.96941192
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94047155
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91085148
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86770586
42Viral carcinogenesis_Homo sapiens_hsa052030.82721583
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78770239
44HTLV-I infection_Homo sapiens_hsa051660.76405348
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70985598
46Thyroid cancer_Homo sapiens_hsa052160.68435879
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68067665
48Vitamin B6 metabolism_Homo sapiens_hsa007500.67835899
49Legionellosis_Homo sapiens_hsa051340.64397125
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62819286
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62275009
52Systemic lupus erythematosus_Homo sapiens_hsa053220.62045222
53MicroRNAs in cancer_Homo sapiens_hsa052060.61958285
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.61758102
55Hippo signaling pathway_Homo sapiens_hsa043900.61682474
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61279983
57Huntingtons disease_Homo sapiens_hsa050160.59710691
58Basal cell carcinoma_Homo sapiens_hsa052170.58146035
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.56274887
60Lysine degradation_Homo sapiens_hsa003100.55624405
61Primary immunodeficiency_Homo sapiens_hsa053400.53730194
62Colorectal cancer_Homo sapiens_hsa052100.53191034
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52325653
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51353599
65Fatty acid metabolism_Homo sapiens_hsa012120.50355836
66TGF-beta signaling pathway_Homo sapiens_hsa043500.49554232
67Pentose phosphate pathway_Homo sapiens_hsa000300.48452726
68Measles_Homo sapiens_hsa051620.45352389
69Shigellosis_Homo sapiens_hsa051310.45253768
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44643688
71Fructose and mannose metabolism_Homo sapiens_hsa000510.44420887
72Notch signaling pathway_Homo sapiens_hsa043300.43718183
73Small cell lung cancer_Homo sapiens_hsa052220.43361836
74Biosynthesis of amino acids_Homo sapiens_hsa012300.42980941
75Parkinsons disease_Homo sapiens_hsa050120.41832953
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.41518247
77Hedgehog signaling pathway_Homo sapiens_hsa043400.40399574
78Apoptosis_Homo sapiens_hsa042100.39212345
79Allograft rejection_Homo sapiens_hsa053300.39029395
80N-Glycan biosynthesis_Homo sapiens_hsa005100.37846476
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.37502599
82Folate biosynthesis_Homo sapiens_hsa007900.36088205
83Selenocompound metabolism_Homo sapiens_hsa004500.35825572
84Metabolic pathways_Homo sapiens_hsa011000.35477038
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34812793
86Hepatitis B_Homo sapiens_hsa051610.34499740
87Viral myocarditis_Homo sapiens_hsa054160.34039894
88Arginine and proline metabolism_Homo sapiens_hsa003300.33220449
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.31209701
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30908813
91Influenza A_Homo sapiens_hsa051640.30261278
92Graft-versus-host disease_Homo sapiens_hsa053320.29930341
93Type I diabetes mellitus_Homo sapiens_hsa049400.29908764
94Pathways in cancer_Homo sapiens_hsa052000.29764782
95Glutathione metabolism_Homo sapiens_hsa004800.29340148
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29041848
97Wnt signaling pathway_Homo sapiens_hsa043100.27791437
98Sulfur relay system_Homo sapiens_hsa041220.25816088
99Alcoholism_Homo sapiens_hsa050340.25159459
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.25098528
101Autoimmune thyroid disease_Homo sapiens_hsa053200.24628795
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23576299
103Prostate cancer_Homo sapiens_hsa052150.22822439
104Chronic myeloid leukemia_Homo sapiens_hsa052200.22539335
105Galactose metabolism_Homo sapiens_hsa000520.21451781
106Regulation of autophagy_Homo sapiens_hsa041400.20080501
107Bladder cancer_Homo sapiens_hsa052190.19245270
108Adherens junction_Homo sapiens_hsa045200.18939137
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17670135
110HIF-1 signaling pathway_Homo sapiens_hsa040660.17161090
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17146951
112Tight junction_Homo sapiens_hsa045300.15362667
113Hematopoietic cell lineage_Homo sapiens_hsa046400.15355353
114Oxidative phosphorylation_Homo sapiens_hsa001900.15008195
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14228894
116Vibrio cholerae infection_Homo sapiens_hsa051100.13122500
117Acute myeloid leukemia_Homo sapiens_hsa052210.12335217
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11284301
119Endometrial cancer_Homo sapiens_hsa052130.11250691
120Melanoma_Homo sapiens_hsa052180.10740801
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10519749
122Pancreatic cancer_Homo sapiens_hsa052120.09921852
123Asthma_Homo sapiens_hsa053100.09915325
124Arachidonic acid metabolism_Homo sapiens_hsa005900.09310249
125Carbon metabolism_Homo sapiens_hsa012000.08943502
126Alzheimers disease_Homo sapiens_hsa050100.08087026

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