ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of acrosome reaction (GO:0060046)	4.58223493
2	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.52132127
3	positive regulation of prostaglandin secretion (GO:0032308)	4.49763917
4	rRNA modification (GO:0000154)	4.48875292
5	DNA deamination (GO:0045006)	4.36731566
6	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.35816483
7	multicellular organism reproduction (GO:0032504)	4.28172961
8	male meiosis I (GO:0007141)	4.20187023
9	rRNA methylation (GO:0031167)	4.17348129
10	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	32.9330205
11	meiosis I (GO:0007127)	3.78964629
12	regulation of prostaglandin secretion (GO:0032306)	3.70470211
13	regulation of female gonad development (GO:2000194)	3.69272292
14	protein kinase C signaling (GO:0070528)	3.46586365
15	chaperone-mediated protein transport (GO:0072321)	3.45681787
16	aggressive behavior (GO:0002118)	3.45533515
17	positive regulation of humoral immune response (GO:0002922)	3.42910088
18	transcription from mitochondrial promoter (GO:0006390)	3.42431371
19	regulation of uterine smooth muscle contraction (GO:0070472)	3.35625529
20	sleep (GO:0030431)	3.28163561
21	maturation of SSU-rRNA (GO:0030490)	3.24487877
22	proteasome assembly (GO:0043248)	3.17743319
23	termination of RNA polymerase III transcription (GO:0006386)	3.16666275
24	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.16666275
25	regulation of penile erection (GO:0060405)	3.16535533
26	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.12767852
27	regulation of female receptivity (GO:0045924)	3.08145625
28	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.07207733
29	regulation of retinoic acid receptor signaling pathway (GO:0048385)	27.8225448
30	hyperosmotic salinity response (GO:0042538)	2.98470328
31	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.97096539
32	glycine transport (GO:0015816)	2.94792212
33	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.94287981
34	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.93408823
35	positive regulation of fatty acid transport (GO:2000193)	2.93252235
36	drinking behavior (GO:0042756)	2.88868363
37	positive regulation of icosanoid secretion (GO:0032305)	2.84928864
38	cytidine metabolic process (GO:0046087)	2.84707603
39	cytidine catabolic process (GO:0006216)	2.84707603
40	cytidine deamination (GO:0009972)	2.84707603
41	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.83528009
42	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.81595002
43	reproduction (GO:0000003)	2.81470684
44	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.80517539
45	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.77264561
46	mitochondrial RNA metabolic process (GO:0000959)	2.75981853
47	ribosome assembly (GO:0042255)	2.75640035
48	protein K6-linked ubiquitination (GO:0085020)	2.74392306
49	male meiosis (GO:0007140)	2.69633937
50	female mating behavior (GO:0060180)	2.66241255
51	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.65957088
52	negative regulation of ligase activity (GO:0051352)	2.63799053
53	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.63799053
54	negative regulation of reproductive process (GO:2000242)	2.63570417
55	regulation of DNA methylation (GO:0044030)	2.63375300
56	regulation of cellular amino acid metabolic process (GO:0006521)	2.59985360
57	positive regulation of ligase activity (GO:0051351)	2.55996525
58	rRNA processing (GO:0006364)	2.54305549
59	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.53078751
60	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.53078751
61	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.51099640
62	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.50089923
63	positive regulation of protein homooligomerization (GO:0032464)	2.49181759
64	binding of sperm to zona pellucida (GO:0007339)	2.49099221
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.48856708
66	oocyte development (GO:0048599)	2.47421393
67	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.46475922
68	rRNA metabolic process (GO:0016072)	2.44251219
69	histone mRNA metabolic process (GO:0008334)	2.42656802
70	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.40592461
71	telomere maintenance via telomere lengthening (GO:0010833)	2.40579857
72	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.39683178
73	positive regulation of digestive system process (GO:0060456)	2.37723873
74	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.37663764
75	negative regulation of digestive system process (GO:0060457)	2.36636622
76	sperm-egg recognition (GO:0035036)	2.36070971
77	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.34853661
78	positive regulation of interleukin-17 production (GO:0032740)	2.32304020
79	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.31920582
80	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.31920582
81	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.31920582
82	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.31324071
83	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.31324071
84	transcription from RNA polymerase III promoter (GO:0006383)	2.29248071
85	positive regulation of catecholamine secretion (GO:0033605)	2.28780947
86	base-excision repair, AP site formation (GO:0006285)	2.28105762
87	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.26464995
88	regulation of RIG-I signaling pathway (GO:0039535)	2.25673651
89	piRNA metabolic process (GO:0034587)	2.25465010
90	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.25004613
91	ATP synthesis coupled proton transport (GO:0015986)	2.25004613
92	ribosomal small subunit assembly (GO:0000028)	2.20196389
93	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.19464883
94	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.18761897
95	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.18761897
96	mitotic metaphase plate congression (GO:0007080)	2.16690677
97	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.14867395
98	DNA replication checkpoint (GO:0000076)	2.14714055
99	meiotic cell cycle (GO:0051321)	2.13347977
100	regulation of ligase activity (GO:0051340)	2.13166283

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.88679687
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.37726610
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.09696370
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.78390118
5	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.75836672
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.27361530
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.25759166
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.20030684
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.15828746
10	E2F7_22180533_ChIP-Seq_HELA_Human	3.12804593
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.07160811
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.06899995
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.94250962
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89062396
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.67574926
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.63486508
17	MYC_18940864_ChIP-ChIP_HL60_Human	2.29480449
18	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.19797436
19	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.18389791
20	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.18389791
21	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.18389791
22	FOXP3_21729870_ChIP-Seq_TREG_Human	2.09349639
23	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.08874208
24	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.07520429
25	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.97668085
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.93651606
27	ETV1_20927104_ChIP-Seq_GIST48_Human	1.91093013
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.90531681
29	* RBPJ_21746931_ChIP-Seq_IB4_Human	1.87961879
30	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.86277964
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.78453905
32	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.78351484
33	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.77513045
34	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.76643538
35	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.76202200
36	EZH2_22144423_ChIP-Seq_EOC_Human	1.75995617
37	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.75330175
38	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.75123752
39	VDR_22108803_ChIP-Seq_LS180_Human	1.67838453
40	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.64544223
41	* PHF8_20622853_ChIP-Seq_HELA_Human	1.62926000
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.60981840
43	* NFYB_21822215_ChIP-Seq_K562_Human	1.58853478
44	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.58086269
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.57749649
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54947076
47	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51276128
48	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.49778997
49	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.49057192
50	TTF2_22483619_ChIP-Seq_HELA_Human	1.46165989
51	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.42899566
52	TBL1_22424771_ChIP-Seq_293T_Human	1.40805145
53	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.39166664
54	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.37957152
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.37047993
56	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.36156204
57	GABP_19822575_ChIP-Seq_HepG2_Human	1.35652043
58	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.31522965
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.30814344
60	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.30600291
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.29606956
62	GATA3_26560356_Chip-Seq_TH2_Human	1.29471679
63	XRN2_22483619_ChIP-Seq_HELA_Human	1.27440442
64	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.25473324
65	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.17686613
66	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.17334067
67	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.14263920
68	NFYA_21822215_ChIP-Seq_K562_Human	1.13908689
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12557936
70	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.12553006
71	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.12314938
72	NCOR_22424771_ChIP-Seq_293T_Human	1.11754850
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09782328
74	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.09038717
75	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.08583068
76	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.07035823
77	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05057107
78	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.04725162
79	CIITA_25753668_ChIP-Seq_RAJI_Human	1.04667634
80	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.03861105
81	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.00309735
82	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.99881737
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98905644
84	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.98872158
85	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.97431828
86	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.97331690
87	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.97074538
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.96989310
89	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.96183187
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96179954
91	* PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.96151814
92	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.95650873
93	STAT1_20625510_ChIP-Seq_HELA_Human	0.95426574
94	DCP1A_22483619_ChIP-Seq_HELA_Human	0.94060402
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.93840829
96	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.90076609
97	MYC_19829295_ChIP-Seq_ESCs_Human	0.89497282
98	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.89234826
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89118267
100	SOX2_21211035_ChIP-Seq_LN229_Human	0.89068386

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	4.08747390
2	MP0003718_maternal_effect	4.02739586
3	MP0006292_abnormal_olfactory_placode	3.52760417
4	MP0005423_abnormal_somatic_nervous	2.88981187
5	MP0009379_abnormal_foot_pigmentation	2.77805433
6	MP0003693_abnormal_embryo_hatching	2.64188575
7	MP0002138_abnormal_hepatobiliary_system	2.61891294
8	MP0000372_irregular_coat_pigmentation	2.58143140
9	MP0005410_abnormal_fertilization	2.48151879
10	MP0008877_abnormal_DNA_methylation	2.41689524
11	MP0009333_abnormal_splenocyte_physiolog	2.36714411
12	MP0003195_calcinosis	2.34870312
13	MP0003646_muscle_fatigue	2.11197655
14	MP0010094_abnormal_chromosome_stability	2.09828632
15	MP0008058_abnormal_DNA_repair	2.08449948
16	MP0005671_abnormal_response_to	2.06077893
17	MP0006276_abnormal_autonomic_nervous	2.05926942
18	MP0003136_yellow_coat_color	2.03735336
19	MP0004957_abnormal_blastocyst_morpholog	2.01713901
20	MP0003283_abnormal_digestive_organ	2.01600177
21	MP0002277_abnormal_respiratory_mucosa	1.95869057
22	MP0004142_abnormal_muscle_tone	1.92453303
23	MP0001929_abnormal_gametogenesis	1.88977646
24	MP0001881_abnormal_mammary_gland	1.88190467
25	MP0003786_premature_aging	1.84566155
26	MP0005360_urolithiasis	1.81851323
27	MP0005499_abnormal_olfactory_system	1.79436028
28	MP0005394_taste/olfaction_phenotype	1.79436028
29	MP0002210_abnormal_sex_determination	1.76826105
30	MP0005389_reproductive_system_phenotype	1.76387654
31	MP0005395_other_phenotype	1.75388405
32	MP0002160_abnormal_reproductive_system	1.70741164
33	MP0003866_abnormal_defecation	1.70136173
34	MP0001835_abnormal_antigen_presentation	1.57236358
35	MP0002102_abnormal_ear_morphology	1.55670248
36	MP0008789_abnormal_olfactory_epithelium	1.55291910
37	MP0005646_abnormal_pituitary_gland	1.53456494
38	MP0003077_abnormal_cell_cycle	1.49885690
39	MP0005647_abnormal_sex_gland	1.45831430
40	MP0002139_abnormal_hepatobiliary_system	1.44128177
41	MP0005645_abnormal_hypothalamus_physiol	1.44058855
42	MP0001502_abnormal_circadian_rhythm	1.43106177
43	MP0006036_abnormal_mitochondrial_physio	1.42996116
44	MP0008932_abnormal_embryonic_tissue	1.41399374
45	MP0003111_abnormal_nucleus_morphology	1.41348307
46	MP0005075_abnormal_melanosome_morpholog	1.32468519
47	MP0010368_abnormal_lymphatic_system	1.32061133
48	MP0001984_abnormal_olfaction	1.30795575
49	MP0000653_abnormal_sex_gland	1.27154559
50	MP0001919_abnormal_reproductive_system	1.26684535
51	MP0005387_immune_system_phenotype	1.24869496
52	MP0001790_abnormal_immune_system	1.24869496
53	MP0001119_abnormal_female_reproductive	1.15995785
54	MP0002127_abnormal_cardiovascular_syste	1.12352465
55	MP0009785_altered_susceptibility_to	1.11151214
56	MP0003699_abnormal_female_reproductive	1.07885602
57	MP0002148_abnormal_hypersensitivity_rea	1.07356588
58	MP0008995_early_reproductive_senescence	1.03450166
59	MP0001529_abnormal_vocalization	1.02305721
60	MP0003698_abnormal_male_reproductive	1.01485354
61	MP0001145_abnormal_male_reproductive	1.00482547
62	MP0001800_abnormal_humoral_immune	1.00385770
63	MP0010307_abnormal_tumor_latency	0.97859358
64	MP0004215_abnormal_myocardial_fiber	0.97321168
65	MP0001968_abnormal_touch/_nociception	0.97297416
66	MP0002006_tumorigenesis	0.97174300
67	MP0005551_abnormal_eye_electrophysiolog	0.95706547
68	MP0003567_abnormal_fetal_cardiomyocyte	0.94603016
69	MP0002161_abnormal_fertility/fecundity	0.93879974
70	MP0001501_abnormal_sleep_pattern	0.93759420
71	MP0005000_abnormal_immune_tolerance	0.92069346
72	MP0003186_abnormal_redox_activity	0.90035721
73	MP0002736_abnormal_nociception_after	0.84797273
74	MP0001853_heart_inflammation	0.83434872
75	MP0003252_abnormal_bile_duct	0.82997392
76	MP0008872_abnormal_physiological_respon	0.81732817
77	MP0006072_abnormal_retinal_apoptosis	0.79391430
78	MP0002420_abnormal_adaptive_immunity	0.78897469
79	MP0002166_altered_tumor_susceptibility	0.78797026
80	MP0002938_white_spotting	0.78564989
81	MP0004145_abnormal_muscle_electrophysio	0.77936426
82	MP0002272_abnormal_nervous_system	0.77843111
83	MP0009697_abnormal_copulation	0.77240591
84	MP0002723_abnormal_immune_serum	0.76167927
85	MP0009840_abnormal_foam_cell	0.74601692
86	MP0001819_abnormal_immune_cell	0.74280049
87	MP0008057_abnormal_DNA_replication	0.72551225
88	MP0005084_abnormal_gallbladder_morpholo	0.71742174
89	MP0001666_abnormal_nutrient_absorption	0.71294022
90	MP0001293_anophthalmia	0.69314516
91	MP0003878_abnormal_ear_physiology	0.68311184
92	MP0005377_hearing/vestibular/ear_phenot	0.68311184
93	MP0002452_abnormal_antigen_presenting	0.67890429
94	MP0000631_abnormal_neuroendocrine_gland	0.67681090
95	MP0000627_abnormal_mammary_gland	0.67581467
96	MP0001485_abnormal_pinna_reflex	0.67357739
97	MP0001440_abnormal_grooming_behavior	0.67159774
98	MP0004742_abnormal_vestibular_system	0.65707527
99	MP0000689_abnormal_spleen_morphology	0.65571054
100	MP0002398_abnormal_bone_marrow	0.63794481

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.77000702
2	3-Methylglutaconic aciduria (HP:0003535)	3.50875162
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.50624006
4	Male infertility (HP:0003251)	3.45114577
5	Mitochondrial inheritance (HP:0001427)	3.37167353
6	Aplasia/hypoplasia of the uterus (HP:0008684)	3.32658905
7	Acute encephalopathy (HP:0006846)	3.22097360
8	Increased hepatocellular lipid droplets (HP:0006565)	3.20469025
9	Increased CSF lactate (HP:0002490)	3.18300405
10	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.18155985
11	Premature ovarian failure (HP:0008209)	3.17214783
12	Stomatitis (HP:0010280)	3.11192091
13	Rhinitis (HP:0012384)	3.01425033
14	Progressive macrocephaly (HP:0004481)	3.00822067
15	Increased serum lactate (HP:0002151)	2.95521502
16	Hypoplasia of the fovea (HP:0007750)	2.86946638
17	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.86946638
18	IgG deficiency (HP:0004315)	2.84973798
19	Lipid accumulation in hepatocytes (HP:0006561)	2.82774222
20	Type 2 muscle fiber atrophy (HP:0003554)	2.79694722
21	Carpal bone hypoplasia (HP:0001498)	2.77373244
22	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.72307950
23	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.71282701
24	Abnormality of alanine metabolism (HP:0010916)	2.71282701
25	Hyperalaninemia (HP:0003348)	2.71282701
26	Constricted visual fields (HP:0001133)	2.70048272
27	Sensory axonal neuropathy (HP:0003390)	2.66564626
28	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.66489078
29	Cerebral edema (HP:0002181)	2.65952645
30	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.65845208
31	Abnormal number of erythroid precursors (HP:0012131)	2.62209151
32	Severe combined immunodeficiency (HP:0004430)	2.61864830
33	Pendular nystagmus (HP:0012043)	2.57890176
34	Aplastic anemia (HP:0001915)	2.55008167
35	Increased intramyocellular lipid droplets (HP:0012240)	2.52981175
36	Malnutrition (HP:0004395)	2.50530930
37	Hypoplasia of the uterus (HP:0000013)	2.48007418
38	Pancreatic cysts (HP:0001737)	2.41333443
39	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.40440694
40	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.39141261
41	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.39141261
42	Abnormality of the fovea (HP:0000493)	2.38594031
43	Renal Fanconi syndrome (HP:0001994)	2.38458970
44	Abolished electroretinogram (ERG) (HP:0000550)	2.37706034
45	Abnormality of cells of the erythroid lineage (HP:0012130)	2.36886939
46	Attenuation of retinal blood vessels (HP:0007843)	2.32929213
47	Delayed CNS myelination (HP:0002188)	2.32671418
48	Molar tooth sign on MRI (HP:0002419)	2.32608025
49	Abnormality of midbrain morphology (HP:0002418)	2.32608025
50	Microvesicular hepatic steatosis (HP:0001414)	2.32569079
51	Optic disc pallor (HP:0000543)	2.30717570
52	Hepatocellular necrosis (HP:0001404)	2.30659213
53	Reticulocytopenia (HP:0001896)	2.29867281
54	Abnormality of the ileum (HP:0001549)	2.26116159
55	Lactic acidosis (HP:0003128)	2.25779525
56	Abnormal biliary tract physiology (HP:0012439)	2.25317614
57	Bile duct proliferation (HP:0001408)	2.25317614
58	Hepatic necrosis (HP:0002605)	2.24830997
59	Muscle fiber atrophy (HP:0100295)	2.24696604
60	Abnormal respiratory epithelium morphology (HP:0012253)	2.24534879
61	Abnormal respiratory motile cilium morphology (HP:0005938)	2.24534879
62	Meckel diverticulum (HP:0002245)	2.22896714
63	Chronic diarrhea (HP:0002028)	2.22450119
64	Congenital ichthyosiform erythroderma (HP:0007431)	2.22034972
65	Abnormal rod and cone electroretinograms (HP:0008323)	2.19619520
66	Concave nail (HP:0001598)	2.18175732
67	Exercise intolerance (HP:0003546)	2.16570800
68	Exertional dyspnea (HP:0002875)	2.13048593
69	Abnormality of the septum pellucidum (HP:0007375)	2.05740739
70	Abnormality of urine glucose concentration (HP:0011016)	2.05131002
71	Glycosuria (HP:0003076)	2.05131002
72	Combined immunodeficiency (HP:0005387)	2.00831066
73	Infertility (HP:0000789)	1.98151631
74	Testicular atrophy (HP:0000029)	1.96757518
75	Pancytopenia (HP:0001876)	1.96687660
76	Increased muscle lipid content (HP:0009058)	1.95356080
77	Increased IgM level (HP:0003496)	1.94734416
78	Absent thumb (HP:0009777)	1.93934641
79	Cleft eyelid (HP:0000625)	1.93288863
80	Progressive muscle weakness (HP:0003323)	1.91158278
81	Horseshoe kidney (HP:0000085)	1.87846367
82	T lymphocytopenia (HP:0005403)	1.86622766
83	Anhidrosis (HP:0000970)	1.84330302
84	Absent septum pellucidum (HP:0001331)	1.84168679
85	Abnormality of T cell number (HP:0011839)	1.83000795
86	Nausea (HP:0002018)	1.82545118
87	Hyperphosphaturia (HP:0003109)	1.82307017
88	Respiratory failure (HP:0002878)	1.80865606
89	Sparse eyelashes (HP:0000653)	1.80226688
90	Lethargy (HP:0001254)	1.79671844
91	Abnormality of the renal collecting system (HP:0004742)	1.79626358
92	Congenital stationary night blindness (HP:0007642)	1.77476829
93	Myokymia (HP:0002411)	1.74875506
94	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.74397677
95	Duplicated collecting system (HP:0000081)	1.74293071
96	Abnormal respiratory motile cilium physiology (HP:0012261)	1.73768696
97	Male pseudohermaphroditism (HP:0000037)	1.73654276
98	Abnormality of the preputium (HP:0100587)	1.73398342
99	Parakeratosis (HP:0001036)	1.72660267
100	Abnormal ciliary motility (HP:0012262)	1.72407322

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	5.72632070
2	BUB1	4.41606436
3	EIF2AK3	3.14983138
4	TRIM28	3.02709272
5	VRK2	3.02283227
6	KDR	2.75828708
7	STK16	2.72461741
8	TXK	2.52723381
9	SRPK1	2.50322590
10	BCKDK	2.29988271
11	MUSK	2.16100322
12	TIE1	2.03286247
13	WNK4	1.96329413
14	TAOK3	1.92799248
15	ZAK	1.82865902
16	CDK19	1.82850395
17	VRK1	1.78060442
18	TLK1	1.72477521
19	NME1	1.56126140
20	PLK3	1.54930856
21	BRSK2	1.52349234
22	PDK2	1.46560032
23	NEK6	1.44832874
24	ADRBK2	1.42506464
25	PLK4	1.34409287
26	STK39	1.33451148
27	MAPKAPK3	1.26936896
28	PLK1	1.18291443
29	NUAK1	1.13766660
30	GRK1	1.07785415
31	LIMK1	1.07172912
32	TESK1	1.05659435
33	AURKB	1.05469942
34	PBK	1.02317705
35	BRSK1	1.00696464
36	MARK3	0.98313027
37	CDC7	0.97081982
38	MAPKAPK5	0.96936404
39	MST4	0.96282952
40	AURKA	0.95023954
41	TEC	0.92289275
42	ATR	0.86460663
43	WNK3	0.83976760
44	ACVR1B	0.83909977
45	EIF2AK1	0.83771865
46	MAP3K12	0.83618634
47	ITK	0.82611800
48	FES	0.81861335
49	TTK	0.81336576
50	LATS2	0.78024227
51	NEK2	0.75473953
52	CSNK2A1	0.75405172
53	CSNK2A2	0.73104603
54	DAPK1	0.71434268
55	TSSK6	0.70031129
56	BMPR1B	0.65769373
57	WNK1	0.64781015
58	PRKCG	0.64251275
59	EIF2AK2	0.62812562
60	GRK6	0.62338925
61	MAP4K1	0.61497347
62	CDK7	0.61317380
63	WEE1	0.60073449
64	PIK3CG	0.58905538
65	PRKCI	0.58764480
66	MATK	0.57401974
67	MAP3K5	0.52291766
68	STK3	0.51617459
69	CSNK1G1	0.50758657
70	CHEK2	0.50361918
71	PRKCE	0.49896446
72	NEK1	0.49114207
73	OXSR1	0.48096185
74	RPS6KA5	0.46330037
75	MYLK	0.45549336
76	CSNK1E	0.45505016
77	PKN1	0.44186088
78	CHEK1	0.43854096
79	PAK1	0.42962185
80	CDK8	0.42280472
81	CSNK1G3	0.40237404
82	INSRR	0.35781910
83	MAP3K9	0.35610325
84	LYN	0.34159905
85	CSNK1A1L	0.34116642
86	CSNK1A1	0.33673482
87	GSK3A	0.33252464
88	SIK3	0.33005620
89	MAPK11	0.32765052
90	KIT	0.31508710
91	STK4	0.30922513
92	SYK	0.30873069
93	MAPKAPK2	0.29485462
94	CLK1	0.29469261
95	PRKCQ	0.28721274
96	ATM	0.27067247
97	PRKCA	0.25819038
98	TGFBR1	0.25030560
99	IGF1R	0.24269779
100	IKBKB	0.24123888

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.39576181
2	Basal transcription factors_Homo sapiens_hsa03022	3.85415846
3	Ribosome_Homo sapiens_hsa03010	3.59659643
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.45170928
5	RNA polymerase_Homo sapiens_hsa03020	3.36308272
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.79550255
7	Parkinsons disease_Homo sapiens_hsa05012	2.73538186
8	Spliceosome_Homo sapiens_hsa03040	2.55075066
9	Protein export_Homo sapiens_hsa03060	2.47929477
10	Regulation of autophagy_Homo sapiens_hsa04140	2.17730101
11	RNA transport_Homo sapiens_hsa03013	2.02931881
12	Huntingtons disease_Homo sapiens_hsa05016	1.93068965
13	Folate biosynthesis_Homo sapiens_hsa00790	1.90279776
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.87389920
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.83013489
16	DNA replication_Homo sapiens_hsa03030	1.78547612
17	Mismatch repair_Homo sapiens_hsa03430	1.77439651
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.70303861
19	Base excision repair_Homo sapiens_hsa03410	1.69724196
20	mRNA surveillance pathway_Homo sapiens_hsa03015	1.63902650
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.59731529
22	Homologous recombination_Homo sapiens_hsa03440	1.57544541
23	Allograft rejection_Homo sapiens_hsa05330	1.56072508
24	RNA degradation_Homo sapiens_hsa03018	1.55444902
25	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.53450826
26	Sulfur metabolism_Homo sapiens_hsa00920	1.49653407
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.48110371
28	Antigen processing and presentation_Homo sapiens_hsa04612	1.46604696
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.45572944
30	Cell cycle_Homo sapiens_hsa04110	1.45470387
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.45415877
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.42611880
33	Alzheimers disease_Homo sapiens_hsa05010	1.40434606
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.23912695
35	Nucleotide excision repair_Homo sapiens_hsa03420	1.23456251
36	Taste transduction_Homo sapiens_hsa04742	1.19861739
37	Asthma_Homo sapiens_hsa05310	1.17776687
38	Type I diabetes mellitus_Homo sapiens_hsa04940	1.08383058
39	Oocyte meiosis_Homo sapiens_hsa04114	1.07474232
40	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.05532118
41	Purine metabolism_Homo sapiens_hsa00230	1.01796845
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.00101167
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.98606974
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.96790308
45	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.92390662
46	Propanoate metabolism_Homo sapiens_hsa00640	0.91941762
47	Caffeine metabolism_Homo sapiens_hsa00232	0.91537216
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90747960
49	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.90651858
50	p53 signaling pathway_Homo sapiens_hsa04115	0.89725580
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.88596885
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.87409377
53	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.82624053
54	Fatty acid elongation_Homo sapiens_hsa00062	0.82021424
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.80934825
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80894545
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.79756366
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.71991300
59	Olfactory transduction_Homo sapiens_hsa04740	0.70743575
60	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.70740225
61	Phototransduction_Homo sapiens_hsa04744	0.64704227
62	Linoleic acid metabolism_Homo sapiens_hsa00591	0.61890554
63	Rheumatoid arthritis_Homo sapiens_hsa05323	0.59635371
64	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.57964592
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57051427
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.56303108
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55445738
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52921151
69	Herpes simplex infection_Homo sapiens_hsa05168	0.50311946
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.48507714
71	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.46394848
72	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.45698475
73	Metabolic pathways_Homo sapiens_hsa01100	0.45311910
74	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.43153545
75	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.42894518
76	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.42285202
77	Retinol metabolism_Homo sapiens_hsa00830	0.41433313
78	Nitrogen metabolism_Homo sapiens_hsa00910	0.40934078
79	Measles_Homo sapiens_hsa05162	0.39852737
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.39309249
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.37193479
82	Viral carcinogenesis_Homo sapiens_hsa05203	0.36013183
83	Peroxisome_Homo sapiens_hsa04146	0.35456669
84	One carbon pool by folate_Homo sapiens_hsa00670	0.35327967
85	Legionellosis_Homo sapiens_hsa05134	0.33967878
86	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.32162333
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30287941
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.30173429
89	Serotonergic synapse_Homo sapiens_hsa04726	0.27618293
90	Mineral absorption_Homo sapiens_hsa04978	0.27212464
91	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.26610255
92	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.25448581
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.23604592
94	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.23544897
95	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.23502271
96	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.23472413
97	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.19000058
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.18966301
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.16216122
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.14900815

HNRNPCL1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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