ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis I (GO:0007141)	5.51790230
2	regulation of acrosome reaction (GO:0060046)	5.09368879
3	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	42.7445843
4	meiosis I (GO:0007127)	4.74660117
5	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.33160123
6	multicellular organism reproduction (GO:0032504)	4.17847776
7	regulation of female gonad development (GO:2000194)	4.07650789
8	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	4.07291432
9	regulation of retinoic acid receptor signaling pathway (GO:0048385)	35.7995542
10	regulation of DNA methylation (GO:0044030)	3.96696222
11	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.69650323
12	aggressive behavior (GO:0002118)	3.65349316
13	regulation of female receptivity (GO:0045924)	3.61147965
14	hyperosmotic salinity response (GO:0042538)	3.35947663
15	positive regulation of prostaglandin secretion (GO:0032308)	3.35617330
16	rRNA modification (GO:0000154)	3.35573386
17	drinking behavior (GO:0042756)	3.35500818
18	transcription from mitochondrial promoter (GO:0006390)	3.32082395
19	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.31251681
20	regulation of uterine smooth muscle contraction (GO:0070472)	3.28579877
21	mitotic chromosome condensation (GO:0007076)	3.28137345
22	positive regulation of humoral immune response (GO:0002922)	3.23207138
23	protein kinase C signaling (GO:0070528)	3.22531448
24	male meiosis (GO:0007140)	3.20570532
25	regulation of penile erection (GO:0060405)	3.19763326
26	rRNA methylation (GO:0031167)	3.15287221
27	sleep (GO:0030431)	3.09777806
28	female mating behavior (GO:0060180)	3.08562269
29	maturation of SSU-rRNA (GO:0030490)	2.96884176
30	mitotic metaphase plate congression (GO:0007080)	2.96838614
31	oocyte development (GO:0048599)	2.94449229
32	positive regulation of digestive system process (GO:0060456)	2.91546889
33	ribosome assembly (GO:0042255)	2.87893767
34	positive regulation of catecholamine secretion (GO:0033605)	2.86857460
35	negative regulation of reproductive process (GO:2000242)	2.85420869
36	response to acidic pH (GO:0010447)	2.83722604
37	regulation of prostaglandin secretion (GO:0032306)	2.83564233
38	reproduction (GO:0000003)	2.75784332
39	telomere maintenance via telomere lengthening (GO:0010833)	2.74963949
40	negative regulation of digestive system process (GO:0060457)	2.70459950
41	cellular response to pH (GO:0071467)	2.58908691
42	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.58505523
43	chaperone-mediated protein transport (GO:0072321)	2.58457036
44	glycine transport (GO:0015816)	2.53909735
45	binding of sperm to zona pellucida (GO:0007339)	2.51468403
46	regulation of spindle organization (GO:0090224)	2.49431849
47	meiotic cell cycle (GO:0051321)	2.48217964
48	regulation of mitotic spindle organization (GO:0060236)	2.43753905
49	positive regulation of protein homooligomerization (GO:0032464)	2.41643862
50	metaphase plate congression (GO:0051310)	2.40638438
51	N-terminal protein amino acid acetylation (GO:0006474)	2.35266518
52	ventricular cardiac muscle cell development (GO:0055015)	2.34113448
53	termination of RNA polymerase III transcription (GO:0006386)	2.32469127
54	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.32469127
55	meiotic nuclear division (GO:0007126)	2.32245831
56	autophagic vacuole assembly (GO:0000045)	2.32046522
57	maternal behavior (GO:0042711)	2.27667131
58	chromosome condensation (GO:0030261)	2.26753440
59	regulation of histone H3-K9 methylation (GO:0051570)	2.24822695
60	protein K6-linked ubiquitination (GO:0085020)	2.23742513
61	positive regulation of reproductive process (GO:2000243)	2.18111872
62	regulation of norepinephrine secretion (GO:0014061)	2.18032687
63	protein localization to chromosome, centromeric region (GO:0071459)	2.17308132
64	ribosome biogenesis (GO:0042254)	2.11214542
65	DNA replication checkpoint (GO:0000076)	2.10599746
66	regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)	2.09706849
67	piRNA metabolic process (GO:0034587)	2.08087066
68	positive regulation of icosanoid secretion (GO:0032305)	2.07541602
69	rRNA processing (GO:0006364)	2.06671901
70	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.06206435
71	attachment of spindle microtubules to kinetochore (GO:0008608)	2.05416932
72	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.04334327
73	DNA replication initiation (GO:0006270)	2.04212184
74	positive regulation of fatty acid transport (GO:2000193)	2.01508651
75	polyamine biosynthetic process (GO:0006596)	2.01459289
76	parental behavior (GO:0060746)	2.01240175
77	regulation of exit from mitosis (GO:0007096)	2.00847814
78	meiotic cell cycle process (GO:1903046)	2.00819562
79	sperm-egg recognition (GO:0035036)	2.00484854
80	CENP-A containing nucleosome assembly (GO:0034080)	1.98549973
81	histone H3-K9 demethylation (GO:0033169)	1.97915732
82	snRNA transcription (GO:0009301)	1.96753882
83	rRNA metabolic process (GO:0016072)	1.96539901
84	positive regulation of histone H3-K4 methylation (GO:0051571)	1.95586277
85	mitochondrial RNA metabolic process (GO:0000959)	1.93945836
86	positive regulation of chromosome segregation (GO:0051984)	1.93369837
87	response to food (GO:0032094)	1.92668792
88	single fertilization (GO:0007338)	1.91919474
89	histone mRNA metabolic process (GO:0008334)	1.91524758
90	regulation of helicase activity (GO:0051095)	1.91060444
91	regulation of cell cycle G2/M phase transition (GO:1902749)	1.90206064
92	muscle organ morphogenesis (GO:0048644)	1.88654925
93	oocyte maturation (GO:0001556)	1.86761450
94	transcription elongation from RNA polymerase II promoter (GO:0006368)	1.86028452
95	L-amino acid import (GO:0043092)	1.85906342
96	DNA packaging (GO:0006323)	1.84019656
97	ribonucleoprotein complex biogenesis (GO:0022613)	1.82488532
98	androgen receptor signaling pathway (GO:0030521)	1.80709504
99	regulation of RNA export from nucleus (GO:0046831)	1.80312268
100	positive regulation of renal sodium excretion (GO:0035815)	1.79645752

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.79972073
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.72830098
3	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	4.72611147
4	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	4.72611147
5	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	4.72611147
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.43493652
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.29245939
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.11070086
9	E2F7_22180533_ChIP-Seq_HELA_Human	3.75759143
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.58662951
11	ZNF274_21170338_ChIP-Seq_K562_Hela	3.25067032
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.23194541
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.13220572
14	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.04037016
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.80472715
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.70445746
17	ETV1_20927104_ChIP-Seq_GIST48_Human	2.69595842
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.68807084
19	RBPJ_21746931_ChIP-Seq_IB4_Human	2.57767787
20	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.54571874
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.52460783
22	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.50655189
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.47526614
24	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.35210962
25	NFYB_21822215_ChIP-Seq_K562_Human	2.33645467
26	TBL1_22424771_ChIP-Seq_293T_Human	2.30429862
27	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.24437239
28	PHF8_20622853_ChIP-Seq_HELA_Human	2.24075298
29	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	2.15601870
30	MYC_18940864_ChIP-ChIP_HL60_Human	2.11099772
31	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.07532491
32	GATA6_21074721_ChIP-Seq_CACO-2_Human	2.05897007
33	AR_21909140_ChIP-Seq_LNCAP_Human	1.98568711
34	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.97653351
35	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.96147669
36	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.92715462
37	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.85393585
38	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.84802769
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.82692757
40	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.74349748
41	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.74218090
42	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.69145434
43	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.64488031
44	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.54567384
45	TTF2_22483619_ChIP-Seq_HELA_Human	1.50758070
46	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.48705321
47	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.46740333
48	NFYA_21822215_ChIP-Seq_K562_Human	1.44549767
49	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.42572677
50	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.41724500
51	FOXP3_21729870_ChIP-Seq_TREG_Human	1.39656340
52	XRN2_22483619_ChIP-Seq_HELA_Human	1.35200187
53	NANOG_20526341_ChIP-Seq_ESCs_Human	1.32392830
54	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.28168480
55	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.28159655
56	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26945808
57	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.26934628
58	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.25130407
59	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.23537693
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.20108058
61	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.20055288
62	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.16367316
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15192077
64	STAT1_20625510_ChIP-Seq_HELA_Human	1.11379852
65	RAC3_21632823_ChIP-Seq_H3396_Human	1.08373715
66	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06444790
67	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.06303553
68	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.03723150
69	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98923372
70	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.96582219
71	SOX2_21211035_ChIP-Seq_LN229_Human	0.95641849
72	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.94374990
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.92024287
74	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91747362
75	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.90873312
76	E2F1_20622854_ChIP-Seq_HELA_Human	0.90316697
77	TP53_22573176_ChIP-Seq_HFKS_Human	0.90085368
78	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.88161518
79	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.87081802
80	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.85024754
81	CIITA_25753668_ChIP-Seq_RAJI_Human	0.83665677
82	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.83625586
83	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.83208739
84	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.82980423
85	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.82863178
86	CTCF_20526341_ChIP-Seq_ESCs_Human	0.82090629
87	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.80928199
88	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.79789994
89	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.77314190
90	NCOR_22424771_ChIP-Seq_293T_Human	0.77019211
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.74526938
92	IRF1_19129219_ChIP-ChIP_H3396_Human	0.73809787
93	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.72169535
94	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.71238862
95	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.70857588
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.70506709
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.70404435
98	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.70006366
99	KDM5A_27292631_Chip-Seq_BREAST_Human	0.69170602
100	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.69045202

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.77759060
2	MP0003718_maternal_effect	5.27920046
3	MP0001986_abnormal_taste_sensitivity	4.91261651
4	MP0005423_abnormal_somatic_nervous	4.26656277
5	MP0009379_abnormal_foot_pigmentation	3.32010599
6	MP0005499_abnormal_olfactory_system	3.24992461
7	MP0005394_taste/olfaction_phenotype	3.24992461
8	MP0003693_abnormal_embryo_hatching	3.03281297
9	MP0010307_abnormal_tumor_latency	2.93623066
10	MP0004957_abnormal_blastocyst_morpholog	2.62608305
11	MP0008877_abnormal_DNA_methylation	2.47860367
12	MP0005410_abnormal_fertilization	2.45764496
13	MP0003111_abnormal_nucleus_morphology	2.41727485
14	MP0002160_abnormal_reproductive_system	2.41700188
15	MP0010094_abnormal_chromosome_stability	2.39789218
16	MP0002127_abnormal_cardiovascular_syste	2.35766303
17	MP0001929_abnormal_gametogenesis	2.34956097
18	MP0003077_abnormal_cell_cycle	2.34274053
19	MP0002277_abnormal_respiratory_mucosa	2.32661712
20	MP0002210_abnormal_sex_determination	2.30049202
21	MP0008057_abnormal_DNA_replication	2.22034523
22	MP0008058_abnormal_DNA_repair	2.15173969
23	MP0005395_other_phenotype	2.14331910
24	MP0006276_abnormal_autonomic_nervous	2.06788494
25	MP0008789_abnormal_olfactory_epithelium	2.04462628
26	MP0001881_abnormal_mammary_gland	2.02860344
27	MP0002138_abnormal_hepatobiliary_system	2.02024580
28	MP0009333_abnormal_splenocyte_physiolog	1.89983382
29	MP0005389_reproductive_system_phenotype	1.86561334
30	MP0003195_calcinosis	1.85570491
31	MP0010030_abnormal_orbit_morphology	1.83373230
32	MP0009840_abnormal_foam_cell	1.69514769
33	MP0003699_abnormal_female_reproductive	1.68218320
34	MP0005647_abnormal_sex_gland	1.65629915
35	MP0005360_urolithiasis	1.61715529
36	MP0000653_abnormal_sex_gland	1.60140491
37	MP0000372_irregular_coat_pigmentation	1.57827803
38	MP0002254_reproductive_system_inflammat	1.52153047
39	MP0003646_muscle_fatigue	1.50104009
40	MP0002161_abnormal_fertility/fecundity	1.45494380
41	MP0008932_abnormal_embryonic_tissue	1.41383527
42	MP0005646_abnormal_pituitary_gland	1.39743897
43	MP0003121_genomic_imprinting	1.37396266
44	MP0001145_abnormal_male_reproductive	1.33778809
45	MP0003698_abnormal_male_reproductive	1.33080811
46	MP0001293_anophthalmia	1.30856029
47	MP0008260_abnormal_autophagy	1.28921529
48	MP0001502_abnormal_circadian_rhythm	1.24778639
49	MP0005380_embryogenesis_phenotype	1.21516859
50	MP0001672_abnormal_embryogenesis/_devel	1.21516859
51	MP0002234_abnormal_pharynx_morphology	1.19713268
52	MP0003136_yellow_coat_color	1.17247191
53	MP0000350_abnormal_cell_proliferation	1.10343339
54	MP0001119_abnormal_female_reproductive	1.10203157
55	MP0001730_embryonic_growth_arrest	1.09658982
56	MP0004142_abnormal_muscle_tone	1.07576231
57	MP0002233_abnormal_nose_morphology	0.97330241
58	MP0006036_abnormal_mitochondrial_physio	0.94999320
59	MP0010368_abnormal_lymphatic_system	0.91474872
60	MP0003984_embryonic_growth_retardation	0.91384643
61	MP0003938_abnormal_ear_development	0.91144773
62	MP0001919_abnormal_reproductive_system	0.90192774
63	MP0002139_abnormal_hepatobiliary_system	0.88793111
64	MP0000049_abnormal_middle_ear	0.87446586
65	MP0000627_abnormal_mammary_gland	0.87209028
66	MP0001545_abnormal_hematopoietic_system	0.87051058
67	MP0005397_hematopoietic_system_phenotyp	0.87051058
68	MP0002088_abnormal_embryonic_growth/wei	0.85332242
69	MP0004215_abnormal_myocardial_fiber	0.83887465
70	MP0001697_abnormal_embryo_size	0.83859579
71	MP0003950_abnormal_plasma_membrane	0.77532265
72	MP0003786_premature_aging	0.75774654
73	MP0003936_abnormal_reproductive_system	0.74421404
74	MP0008995_early_reproductive_senescence	0.74416742
75	MP0003879_abnormal_hair_cell	0.73242586
76	MP0001853_heart_inflammation	0.72136511
77	MP0002163_abnormal_gland_morphology	0.69281336
78	MP0003123_paternal_imprinting	0.69202525
79	MP0000358_abnormal_cell_content/	0.68745260
80	MP0001968_abnormal_touch/_nociception	0.67592538
81	MP0000631_abnormal_neuroendocrine_gland	0.65468877
82	MP0000762_abnormal_tongue_morphology	0.65238382
83	MP0004019_abnormal_vitamin_homeostasis	0.64291244
84	MP0001529_abnormal_vocalization	0.62875310
85	MP0003119_abnormal_digestive_system	0.62807781
86	MP0002080_prenatal_lethality	0.62184414
87	MP0002751_abnormal_autonomic_nervous	0.57681319
88	MP0005379_endocrine/exocrine_gland_phen	0.57589575
89	MP0002873_normal_phenotype	0.56528616
90	MP0002169_no_abnormal_phenotype	0.56367963
91	MP0003890_abnormal_embryonic-extraembry	0.55462135
92	MP0001666_abnormal_nutrient_absorption	0.55300219
93	MP0001286_abnormal_eye_development	0.55033097
94	MP0001440_abnormal_grooming_behavior	0.54297297
95	MP0006035_abnormal_mitochondrial_morpho	0.53054895
96	MP0002085_abnormal_embryonic_tissue	0.52773214
97	MP0003186_abnormal_redox_activity	0.52726253
98	MP0002084_abnormal_developmental_patter	0.52481766
99	MP0003866_abnormal_defecation	0.52470808
100	MP0002736_abnormal_nociception_after	0.52444937

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Male infertility (HP:0003251)	7.49975449
2	Malnutrition (HP:0004395)	6.10251757
3	Premature ovarian failure (HP:0008209)	5.11977776
4	Aplasia/hypoplasia of the uterus (HP:0008684)	4.66044911
5	Rhinitis (HP:0012384)	4.26766964
6	Carpal bone hypoplasia (HP:0001498)	4.21239671
7	Hypoplasia of the uterus (HP:0000013)	3.64594717
8	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	3.64040897
9	Hypercortisolism (HP:0001578)	3.63801024
10	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.61101598
11	Sensory axonal neuropathy (HP:0003390)	3.37541468
12	Abnormality of the septum pellucidum (HP:0007375)	3.31346139
13	Infertility (HP:0000789)	3.30918411
14	Hypoplasia of the fovea (HP:0007750)	3.29232039
15	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.29232039
16	Hypophosphatemic rickets (HP:0004912)	3.25970989
17	Patent foramen ovale (HP:0001655)	3.19954809
18	Impulsivity (HP:0100710)	3.15397561
19	Birth length less than 3rd percentile (HP:0003561)	3.15109339
20	Preauricular pit (HP:0004467)	3.08244366
21	Periauricular skin pits (HP:0100277)	3.08244366
22	Steatorrhea (HP:0002570)	3.05281101
23	Muscle stiffness (HP:0003552)	3.04984541
24	Reticulocytopenia (HP:0001896)	2.94855620
25	Aplasia/hypoplasia of the humerus (HP:0006507)	2.91271931
26	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.91241256
27	Myokymia (HP:0002411)	2.90892109
28	Constricted visual fields (HP:0001133)	2.81843812
29	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.80875652
30	Meckel diverticulum (HP:0002245)	2.77165520
31	Short tibia (HP:0005736)	2.76917101
32	Abnormality of the ileum (HP:0001549)	2.71452821
33	Hypergonadotropic hypogonadism (HP:0000815)	2.66689171
34	Abnormality of the preputium (HP:0100587)	2.57458757
35	Fused cervical vertebrae (HP:0002949)	2.56089521
36	Absent septum pellucidum (HP:0001331)	2.56010392
37	Fat malabsorption (HP:0002630)	2.55155802
38	Congenital ichthyosiform erythroderma (HP:0007431)	2.53749488
39	Dysphonia (HP:0001618)	2.52213403
40	Abnormality of the fovea (HP:0000493)	2.51423032
41	Abnormality of abdominal situs (HP:0011620)	2.51018004
42	Abdominal situs inversus (HP:0003363)	2.51018004
43	Attenuation of retinal blood vessels (HP:0007843)	2.49689563
44	Septo-optic dysplasia (HP:0100842)	2.49320659
45	Cleft eyelid (HP:0000625)	2.46683860
46	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.46222929
47	Progressive sensorineural hearing impairment (HP:0000408)	2.45779326
48	Multiple enchondromatosis (HP:0005701)	2.44671592
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.41620502
50	Abnormal ciliary motility (HP:0012262)	2.37116425
51	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.35498296
52	Absent/shortened dynein arms (HP:0200106)	2.35498296
53	Absent thumb (HP:0009777)	2.34700384
54	Anterior segment dysgenesis (HP:0007700)	2.31558451
55	Hypoglycemic seizures (HP:0002173)	2.31038556
56	Limb dystonia (HP:0002451)	2.30873507
57	Delayed CNS myelination (HP:0002188)	2.30554739
58	Facial cleft (HP:0002006)	2.30090778
59	Abnormal pancreas size (HP:0012094)	2.29038652
60	Testicular atrophy (HP:0000029)	2.28538361
61	Fibular aplasia (HP:0002990)	2.27094553
62	Horseshoe kidney (HP:0000085)	2.25116866
63	Pendular nystagmus (HP:0012043)	2.24430974
64	Progressive hearing impairment (HP:0001730)	2.23409420
65	Chromsome breakage (HP:0040012)	2.22299404
66	Ureteral duplication (HP:0000073)	2.19678462
67	Microretrognathia (HP:0000308)	2.17936785
68	Azoospermia (HP:0000027)	2.17574302
69	Adrenal overactivity (HP:0002717)	2.16266004
70	Glossoptosis (HP:0000162)	2.15037417
71	Congenital malformation of the right heart (HP:0011723)	2.14562600
72	Double outlet right ventricle (HP:0001719)	2.14562600
73	Absent radius (HP:0003974)	2.14197936
74	Increased circulating renin level (HP:0000848)	2.14071715
75	Abnormal respiratory epithelium morphology (HP:0012253)	2.13861439
76	Abnormal respiratory motile cilium morphology (HP:0005938)	2.13861439
77	Midline defect of the nose (HP:0004122)	2.11809621
78	Aplasia/Hypoplasia of the scapulae (HP:0006713)	2.07994980
79	Hypoplastic scapulae (HP:0000882)	2.07994980
80	Chronic sinusitis (HP:0011109)	2.06691290
81	Secondary amenorrhea (HP:0000869)	2.03372258
82	Absent forearm bone (HP:0003953)	2.01438796
83	Aplasia involving forearm bones (HP:0009822)	2.01438796
84	Progressive muscle weakness (HP:0003323)	2.01377578
85	Osteomalacia (HP:0002749)	2.00902111
86	Nausea (HP:0002018)	1.99390051
87	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.98353688
88	3-Methylglutaconic aciduria (HP:0003535)	1.96462285
89	Abnormality of cells of the erythroid lineage (HP:0012130)	1.94840642
90	Anhidrosis (HP:0000970)	1.94388142
91	Poor suck (HP:0002033)	1.94166689
92	Cortical visual impairment (HP:0100704)	1.93279265
93	Sparse lateral eyebrow (HP:0005338)	1.89535146
94	Skin pits (HP:0100276)	1.88424490
95	Microvesicular hepatic steatosis (HP:0001414)	1.88025909
96	Abnormal umbilical cord blood vessels (HP:0011403)	1.87865312
97	Single umbilical artery (HP:0001195)	1.87865312
98	Abnormality of the fetal cardiovascular system (HP:0010948)	1.87865312
99	Aplasia/Hypoplasia of the macula (HP:0008059)	1.87469678
100	Abnormal number of erythroid precursors (HP:0012131)	1.84986667

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	5.38249676
2	BUB1	4.81051455
3	SRPK1	4.68339076
4	LATS2	4.21393835
5	TRIM28	3.30220416
6	STK16	3.11243657
7	CDK19	2.80816687
8	NEK6	2.69365857
9	PLK1	2.34409923
10	BRSK2	2.33391870
11	EIF2AK3	2.17815476
12	BRSK1	2.17083024
13	PLK3	2.09109628
14	CDC7	2.07215590
15	ZAK	2.05581181
16	CDK9	1.80038650
17	AURKB	1.73737855
18	DYRK3	1.73046116
19	NEK2	1.64337250
20	PIM2	1.46804671
21	MARK3	1.46447944
22	CDK7	1.45634096
23	TLK1	1.42734602
24	PDK2	1.42041664
25	TTK	1.40557634
26	PBK	1.39507247
27	PRKCI	1.39040986
28	AURKA	1.36917704
29	TAOK3	1.34183892
30	NME1	1.31788968
31	WNK3	1.30307884
32	PLK4	1.27728309
33	CHEK1	1.22245967
34	EIF2AK1	1.21472157
35	GSK3A	1.19381759
36	CSNK1E	1.13949986
37	CDK12	1.08949200
38	ATR	1.05197877
39	MAP3K9	1.03877650
40	VRK2	0.98956570
41	MAP3K5	0.94467029
42	CSNK2A2	0.91901675
43	MELK	0.90534878
44	WNK1	0.87575976
45	CHEK2	0.87392975
46	STK4	0.85954347
47	CSNK2A1	0.84433115
48	PIM1	0.80083778
49	PKN1	0.79417737
50	NTRK3	0.78409668
51	STK3	0.78367192
52	VRK1	0.78244336
53	CDK2	0.72951072
54	RAF1	0.70970490
55	LRRK2	0.69994326
56	WEE1	0.68101926
57	EIF2AK2	0.67503044
58	ACVR1B	0.62805831
59	PAK1	0.62388737
60	PAK2	0.62006406
61	CDK1	0.60980019
62	NUAK1	0.58053708
63	ATM	0.57517126
64	STK24	0.55627154
65	TSSK6	0.48449199
66	TNIK	0.47625940
67	TAF1	0.42410156
68	TEC	0.41388113
69	PLK2	0.39752751
70	CLK1	0.39727371
71	AKT2	0.38662321
72	KDR	0.38417842
73	MTOR	0.35140386
74	PRKG1	0.34392813
75	GSK3B	0.34099083
76	CSNK1D	0.29380186
77	MAPK11	0.28209087
78	MAPK14	0.27911749
79	RPS6KA1	0.27677506
80	ABL2	0.25890583
81	MAPK1	0.25502652
82	PRKACB	0.25031049
83	CSNK1G1	0.24501116
84	GRK1	0.24458965
85	TBK1	0.23678636
86	PRKCG	0.21510574
87	BRD4	0.21228745
88	MAP3K8	0.20988449
89	OXSR1	0.20379329
90	CSNK1A1	0.19835534
91	MAPK4	0.19747748
92	MAP3K4	0.19453536
93	PRKD1	0.19112265
94	GRK5	0.18748615
95	NME2	0.16801015
96	TESK1	0.16441385
97	BMPR1B	0.15701109
98	STK10	0.15693058
99	TIE1	0.15492512
100	CDK11A	0.15347268

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	6.21288217
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.80969158
3	RNA polymerase_Homo sapiens_hsa03020	3.75206508
4	Ribosome_Homo sapiens_hsa03010	3.62041999
5	Regulation of autophagy_Homo sapiens_hsa04140	3.46941001
6	mRNA surveillance pathway_Homo sapiens_hsa03015	3.40371531
7	Cell cycle_Homo sapiens_hsa04110	3.06698665
8	RNA transport_Homo sapiens_hsa03013	3.05655480
9	Spliceosome_Homo sapiens_hsa03040	2.82193622
10	p53 signaling pathway_Homo sapiens_hsa04115	2.45046501
11	Folate biosynthesis_Homo sapiens_hsa00790	2.34754925
12	Mismatch repair_Homo sapiens_hsa03430	2.34111619
13	Oocyte meiosis_Homo sapiens_hsa04114	2.29631005
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.24096848
15	Taste transduction_Homo sapiens_hsa04742	1.98576391
16	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.89607965
17	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.83844803
18	Homologous recombination_Homo sapiens_hsa03440	1.82743628
19	DNA replication_Homo sapiens_hsa03030	1.82621270
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.65935014
21	Base excision repair_Homo sapiens_hsa03410	1.57837672
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.55931093
23	Proteasome_Homo sapiens_hsa03050	1.54144293
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.53582022
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.50786360
26	RNA degradation_Homo sapiens_hsa03018	1.45012635
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.31444604
28	Fatty acid elongation_Homo sapiens_hsa00062	1.27971738
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.25772759
30	Sulfur metabolism_Homo sapiens_hsa00920	1.21830641
31	Huntingtons disease_Homo sapiens_hsa05016	1.21151787
32	Protein export_Homo sapiens_hsa03060	1.18249641
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03384668
34	Purine metabolism_Homo sapiens_hsa00230	1.00843975
35	Parkinsons disease_Homo sapiens_hsa05012	0.99319532
36	Viral carcinogenesis_Homo sapiens_hsa05203	0.99308591
37	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.98550834
38	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.86682995
39	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.85667515
40	Caffeine metabolism_Homo sapiens_hsa00232	0.82799890
41	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.80591807
42	Steroid biosynthesis_Homo sapiens_hsa00100	0.75528694
43	Olfactory transduction_Homo sapiens_hsa04740	0.73624329
44	Herpes simplex infection_Homo sapiens_hsa05168	0.71804764
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66889013
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.59314838
47	MicroRNAs in cancer_Homo sapiens_hsa05206	0.57385315
48	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.53682994
49	Oxidative phosphorylation_Homo sapiens_hsa00190	0.53160256
50	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48412685
51	Wnt signaling pathway_Homo sapiens_hsa04310	0.48275570
52	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.44464096
53	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41365706
54	Mineral absorption_Homo sapiens_hsa04978	0.39250828
55	Serotonergic synapse_Homo sapiens_hsa04726	0.39232466
56	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.38305365
57	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.38181680
58	Hepatitis B_Homo sapiens_hsa05161	0.38139043
59	Arginine and proline metabolism_Homo sapiens_hsa00330	0.37962374
60	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.37325968
61	Nicotine addiction_Homo sapiens_hsa05033	0.34246390
62	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.31602666
63	Insulin secretion_Homo sapiens_hsa04911	0.31002209
64	Glutathione metabolism_Homo sapiens_hsa00480	0.30767250
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.27119734
66	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.26616838
67	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.26124035
68	Legionellosis_Homo sapiens_hsa05134	0.25806780
69	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.22850150
70	Protein digestion and absorption_Homo sapiens_hsa04974	0.21698533
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.21527677
72	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.20723895
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.20694578
74	Metabolic pathways_Homo sapiens_hsa01100	0.20341746
75	Asthma_Homo sapiens_hsa05310	0.20030701
76	ABC transporters_Homo sapiens_hsa02010	0.20018968
77	Small cell lung cancer_Homo sapiens_hsa05222	0.19362414
78	Non-homologous end-joining_Homo sapiens_hsa03450	0.18398715
79	Alcoholism_Homo sapiens_hsa05034	0.17901146
80	AMPK signaling pathway_Homo sapiens_hsa04152	0.17796567
81	Propanoate metabolism_Homo sapiens_hsa00640	0.15910084
82	Pyruvate metabolism_Homo sapiens_hsa00620	0.15754896
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.15641192
84	Bile secretion_Homo sapiens_hsa04976	0.14997079
85	GABAergic synapse_Homo sapiens_hsa04727	0.13585310
86	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.13510037
87	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.11987017
88	HTLV-I infection_Homo sapiens_hsa05166	0.11959823
89	Measles_Homo sapiens_hsa05162	0.09654621
90	Amphetamine addiction_Homo sapiens_hsa05031	0.08443648
91	Morphine addiction_Homo sapiens_hsa05032	0.08100005
92	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.07085088
93	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.06854030
94	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.06129721
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.05791343
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.05648702
97	Influenza A_Homo sapiens_hsa05164	0.05075281
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.04165709
99	Acute myeloid leukemia_Homo sapiens_hsa05221	0.02702033
100	Alzheimers disease_Homo sapiens_hsa05010	0.00754790

HNRNPCL2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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