ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis I (GO:0007141)	7.78239335
2	meiosis I (GO:0007127)	6.64530751
3	regulation of DNA methylation (GO:0044030)	5.03105992
4	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	41.8555627
5	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	4.72896620
6	male meiosis (GO:0007140)	4.22397830
7	regulation of histone H3-K9 methylation (GO:0051570)	4.20534329
8	mitotic chromosome condensation (GO:0007076)	4.06106749
9	regulation of retinoic acid receptor signaling pathway (GO:0048385)	35.0403275
10	mitotic metaphase plate congression (GO:0007080)	3.51388577
11	transcription from mitochondrial promoter (GO:0006390)	3.46266589
12	positive regulation of histone H3-K4 methylation (GO:0051571)	3.42798441
13	attachment of spindle microtubules to kinetochore (GO:0008608)	3.37190351
14	ribosome assembly (GO:0042255)	3.30931641
15	protein localization to chromosome, centromeric region (GO:0071459)	3.30349132
16	regulation of spindle organization (GO:0090224)	3.27496448
17	negative regulation of histone methylation (GO:0031061)	3.24544684
18	regulation of mitotic spindle organization (GO:0060236)	3.22198411
19	snRNA transcription (GO:0009301)	3.10031149
20	meiotic nuclear division (GO:0007126)	3.04029826
21	positive regulation of protein homooligomerization (GO:0032464)	3.03582398
22	aggressive behavior (GO:0002118)	2.99912995
23	regulation of acrosome reaction (GO:0060046)	2.99797901
24	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.99396366
25	oocyte maturation (GO:0001556)	2.93222482
26	meiotic cell cycle (GO:0051321)	2.89334477
27	retinal cone cell development (GO:0046549)	2.88932283
28	regulation of female receptivity (GO:0045924)	2.88566069
29	polyamine biosynthetic process (GO:0006596)	2.85309109
30	kinetochore assembly (GO:0051382)	2.79376469
31	metaphase plate congression (GO:0051310)	2.77796359
32	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.76765010
33	nuclear pore complex assembly (GO:0051292)	2.76586631
34	autophagic vacuole assembly (GO:0000045)	2.76322269
35	regulation of female gonad development (GO:2000194)	2.75798223
36	primitive streak formation (GO:0090009)	2.75291734
37	nuclear pore organization (GO:0006999)	2.73451048
38	regulation of RNA export from nucleus (GO:0046831)	2.69802556
39	regulation of G0 to G1 transition (GO:0070316)	2.68454560
40	drinking behavior (GO:0042756)	2.67889991
41	regulation of meiosis I (GO:0060631)	2.67218186
42	meiotic cell cycle process (GO:1903046)	2.64149802
43	ventricular cardiac muscle cell development (GO:0055015)	2.63992639
44	regulation of exit from mitosis (GO:0007096)	2.63339104
45	positive regulation of cytokinesis (GO:0032467)	2.63295905
46	regulation of helicase activity (GO:0051095)	2.57594397
47	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	2.54838878
48	regulation of penile erection (GO:0060405)	2.50438947
49	positive regulation of gastrulation (GO:2000543)	2.48581631
50	chromosome condensation (GO:0030261)	2.47709775
51	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.46158513
52	negative regulation of meiosis (GO:0045835)	2.45887885
53	female mating behavior (GO:0060180)	2.45827981
54	kinetochore organization (GO:0051383)	2.45570155
55	regulation of histone methylation (GO:0031060)	2.45028963
56	hyperosmotic salinity response (GO:0042538)	2.41733189
57	telomere maintenance via telomere lengthening (GO:0010833)	2.40909710
58	regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)	2.40004207
59	response to acidic pH (GO:0010447)	2.36578415
60	positive regulation of chromosome segregation (GO:0051984)	2.33392490
61	multicellular organism reproduction (GO:0032504)	2.32856926
62	oocyte development (GO:0048599)	2.31251509
63	chaperone-mediated protein transport (GO:0072321)	2.29842740
64	regulation of histone H3-K4 methylation (GO:0051569)	2.28911616
65	rRNA modification (GO:0000154)	2.28449245
66	regulation of cell cycle G2/M phase transition (GO:1902749)	2.28042139
67	positive regulation of prostaglandin secretion (GO:0032308)	2.27609419
68	muscle organ morphogenesis (GO:0048644)	2.26465182
69	DNA replication initiation (GO:0006270)	2.25553580
70	cellular response to pH (GO:0071467)	2.25316806
71	negative regulation of reproductive process (GO:2000242)	2.24155237
72	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.23967951
73	piRNA metabolic process (GO:0034587)	2.23690839
74	maturation of SSU-rRNA (GO:0030490)	2.22660948
75	positive regulation of histone methylation (GO:0031062)	2.20046674
76	positive regulation of catecholamine secretion (GO:0033605)	2.17931222
77	negative regulation of digestive system process (GO:0060457)	2.16772173
78	regulation of nucleobase-containing compound transport (GO:0032239)	2.16684449
79	establishment of chromosome localization (GO:0051303)	2.16626421
80	sleep (GO:0030431)	2.16600735
81	positive regulation of digestive system process (GO:0060456)	2.15694175
82	skeletal muscle tissue regeneration (GO:0043403)	2.14859993
83	neuron fate determination (GO:0048664)	2.12539327
84	regulation of cytokinesis (GO:0032465)	2.10671294
85	androgen receptor signaling pathway (GO:0030521)	2.10622207
86	negative regulation of protein acetylation (GO:1901984)	2.09663459
87	cellular biogenic amine biosynthetic process (GO:0042401)	2.08913341
88	protein localization to chromosome (GO:0034502)	2.08897109
89	CENP-A containing nucleosome assembly (GO:0034080)	2.08402415
90	protein destabilization (GO:0031648)	2.08230704
91	regulation of uterine smooth muscle contraction (GO:0070472)	2.07746264
92	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.03889667
93	DNA packaging (GO:0006323)	2.03751211
94	response to UV-C (GO:0010225)	2.01161750
95	pore complex assembly (GO:0046931)	1.99977148
96	amine biosynthetic process (GO:0009309)	1.95911821
97	N-terminal protein amino acid acetylation (GO:0006474)	1.95364035
98	histone mRNA metabolic process (GO:0008334)	1.95225328
99	positive regulation of cAMP-mediated signaling (GO:0043950)	1.95116349
100	microtubule polymerization or depolymerization (GO:0031109)	1.95107730

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	7.36317505
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.32371719
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	5.74044190
4	EZH2_22144423_ChIP-Seq_EOC_Human	5.39618197
5	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	5.29422022
6	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	5.29422022
7	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	5.29422022
8	E2F7_22180533_ChIP-Seq_HELA_Human	4.92691688
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.41499528
10	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.39107239
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.38631514
12	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.67945362
13	TP63_19390658_ChIP-ChIP_HaCaT_Human	3.45899913
14	ETV1_20927104_ChIP-Seq_GIST48_Human	2.51838323
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.44302936
16	RBPJ_21746931_ChIP-Seq_IB4_Human	2.28348871
17	AR_21909140_ChIP-Seq_LNCAP_Human	2.14918844
18	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.10288541
19	TBL1_22424771_ChIP-Seq_293T_Human	2.08991844
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.08470358
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.00307882
22	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.99845656
23	PHF8_20622853_ChIP-Seq_HELA_Human	1.93408810
24	NFYB_21822215_ChIP-Seq_K562_Human	1.93063275
25	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.81748338
26	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.81028680
27	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.75663752
28	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.72254412
29	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.68767156
30	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.67086531
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.59132160
32	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.56822857
33	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.41701898
34	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.40332919
35	NFYA_21822215_ChIP-Seq_K562_Human	1.34068002
36	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.30141718
37	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.29619596
38	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.25557037
39	ZNF263_19887448_ChIP-Seq_K562_Human	1.19538907
40	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.18836753
41	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.17753423
42	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.13296707
43	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.12685627
44	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.11961252
45	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.08950460
46	VDR_23849224_ChIP-Seq_CD4+_Human	1.07686040
47	TTF2_22483619_ChIP-Seq_HELA_Human	1.07341944
48	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.06806952
49	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.01806381
50	RAC3_21632823_ChIP-Seq_H3396_Human	1.01711499
51	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98867035
52	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.90763681
53	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.87972464
54	NANOG_20526341_ChIP-Seq_ESCs_Human	0.87918652
55	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.86930362
56	XRN2_22483619_ChIP-Seq_HELA_Human	0.85169124
57	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.81528037
58	STAT1_20625510_ChIP-Seq_HELA_Human	0.79166773
59	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.76969665
60	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.76921975
61	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.76751544
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.76336684
63	TP53_22573176_ChIP-Seq_HFKS_Human	0.75762568
64	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.75599290
65	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.75451934
66	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.75162595
67	RNF2_27304074_Chip-Seq_NSC_Mouse	0.74990795
68	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.73270887
69	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.73051321
70	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.72471579
71	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.71879115
72	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.71835740
73	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.70267919
74	IRF1_19129219_ChIP-ChIP_H3396_Human	0.70050623
75	KDM5A_27292631_Chip-Seq_BREAST_Human	0.69014251
76	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.67306975
77	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.67242040
78	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.65983538
79	ELK1_19687146_ChIP-ChIP_HELA_Human	0.64836235
80	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.63344672
81	CIITA_25753668_ChIP-Seq_RAJI_Human	0.63048305
82	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.61646658
83	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.61531731
84	TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.60726275
85	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.59620320
86	GF1_26923725_Chip-Seq_HPCs_Mouse	0.59421535
87	FOXP3_21729870_ChIP-Seq_TREG_Human	0.58673134
88	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.58604402
89	SOX2_21211035_ChIP-Seq_LN229_Human	0.57815480
90	GABP_19822575_ChIP-Seq_HepG2_Human	0.57460676
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.57312338
92	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.57196435
93	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.56523495
94	HOXB7_26014856_ChIP-Seq_BT474_Human	0.56484791
95	TAF15_26573619_Chip-Seq_HEK293_Human	0.55486141
96	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.55439864
97	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.53559344
98	CTCF_20526341_ChIP-Seq_ESCs_Human	0.52381619
99	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.52238522
100	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.51890618

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	6.66120922
2	MP0001986_abnormal_taste_sensitivity	5.19549154
3	MP0005423_abnormal_somatic_nervous	4.76897494
4	MP0003718_maternal_effect	4.76016248
5	MP0005499_abnormal_olfactory_system	3.73601440
6	MP0005394_taste/olfaction_phenotype	3.73601440
7	MP0010307_abnormal_tumor_latency	3.52091733
8	MP0010030_abnormal_orbit_morphology	3.28281409
9	MP0008057_abnormal_DNA_replication	3.20260710
10	MP0002277_abnormal_respiratory_mucosa	2.88789496
11	MP0002127_abnormal_cardiovascular_syste	2.84724205
12	MP0003693_abnormal_embryo_hatching	2.65353827
13	MP0004957_abnormal_blastocyst_morpholog	2.48726914
14	MP0003111_abnormal_nucleus_morphology	2.46876278
15	MP0002160_abnormal_reproductive_system	2.43663022
16	MP0008789_abnormal_olfactory_epithelium	2.29589543
17	MP0003077_abnormal_cell_cycle	2.28569337
18	MP0009379_abnormal_foot_pigmentation	2.23534889
19	MP0010094_abnormal_chromosome_stability	2.22600465
20	MP0008877_abnormal_DNA_methylation	2.20792865
21	MP0003121_genomic_imprinting	2.11113847
22	MP0002138_abnormal_hepatobiliary_system	2.10484897
23	MP0001929_abnormal_gametogenesis	2.06718308
24	MP0002210_abnormal_sex_determination	1.97019773
25	MP0008058_abnormal_DNA_repair	1.93722548
26	MP0002234_abnormal_pharynx_morphology	1.92397210
27	MP0005395_other_phenotype	1.87621558
28	MP0009333_abnormal_splenocyte_physiolog	1.85214324
29	MP0002254_reproductive_system_inflammat	1.83751009
30	MP0005410_abnormal_fertilization	1.73922460
31	MP0001881_abnormal_mammary_gland	1.65905576
32	MP0003136_yellow_coat_color	1.63658894
33	MP0001293_anophthalmia	1.62360119
34	MP0008260_abnormal_autophagy	1.53851876
35	MP0005389_reproductive_system_phenotype	1.49351078
36	MP0003699_abnormal_female_reproductive	1.44530023
37	MP0002161_abnormal_fertility/fecundity	1.40714501
38	MP0003698_abnormal_male_reproductive	1.33125551
39	MP0005380_embryogenesis_phenotype	1.32359090
40	MP0001672_abnormal_embryogenesis/_devel	1.32359090
41	MP0000653_abnormal_sex_gland	1.26132221
42	MP0002233_abnormal_nose_morphology	1.22619351
43	MP0006276_abnormal_autonomic_nervous	1.22148581
44	MP0008932_abnormal_embryonic_tissue	1.20977895
45	MP0000049_abnormal_middle_ear	1.20883794
46	MP0005360_urolithiasis	1.17843869
47	MP0001145_abnormal_male_reproductive	1.17355089
48	MP0000762_abnormal_tongue_morphology	1.16490950
49	MP0003828_pulmonary_edema	1.13315485
50	MP0001730_embryonic_growth_arrest	1.12687169
51	MP0000350_abnormal_cell_proliferation	1.12157912
52	MP0003984_embryonic_growth_retardation	1.11318527
53	MP0003890_abnormal_embryonic-extraembry	1.10500693
54	MP0002088_abnormal_embryonic_growth/wei	1.04997092
55	MP0010368_abnormal_lymphatic_system	1.02206666
56	MP0003195_calcinosis	0.99448846
57	MP0005647_abnormal_sex_gland	0.95301270
58	MP0000428_abnormal_craniofacial_morphol	0.94064757
59	MP0000372_irregular_coat_pigmentation	0.93977597
60	MP0001545_abnormal_hematopoietic_system	0.93659257
61	MP0005397_hematopoietic_system_phenotyp	0.93659257
62	MP0005646_abnormal_pituitary_gland	0.92426763
63	MP0006036_abnormal_mitochondrial_physio	0.91914025
64	MP0002396_abnormal_hematopoietic_system	0.91807639
65	MP0003755_abnormal_palate_morphology	0.91251107
66	MP0000627_abnormal_mammary_gland	0.88846818
67	MP0002751_abnormal_autonomic_nervous	0.87708014
68	MP0004381_abnormal_hair_follicle	0.85157551
69	MP0001697_abnormal_embryo_size	0.85121203
70	MP0000358_abnormal_cell_content/	0.84018065
71	MP0008995_early_reproductive_senescence	0.80543452
72	MP0003938_abnormal_ear_development	0.80492612
73	MP0001502_abnormal_circadian_rhythm	0.77179258
74	MP0003936_abnormal_reproductive_system	0.75482108
75	MP0005197_abnormal_uvea_morphology	0.73069751
76	MP0001286_abnormal_eye_development	0.71762296
77	MP0003646_muscle_fatigue	0.71363448
78	MP0002080_prenatal_lethality	0.66049729
79	MP0000631_abnormal_neuroendocrine_gland	0.64866798
80	MP0002085_abnormal_embryonic_tissue	0.64109674
81	MP0002084_abnormal_developmental_patter	0.63723190
82	MP0001119_abnormal_female_reproductive	0.60376165
83	MP0002092_abnormal_eye_morphology	0.57409087
84	MP0003935_abnormal_craniofacial_develop	0.57250884
85	MP0002873_normal_phenotype	0.56667171
86	MP0002169_no_abnormal_phenotype	0.56591418
87	MP0003119_abnormal_digestive_system	0.55914415
88	MP0002139_abnormal_hepatobiliary_system	0.54876500
89	MP0002089_abnormal_postnatal_growth/wei	0.54295377
90	MP0002086_abnormal_extraembryonic_tissu	0.53537475
91	MP0009840_abnormal_foam_cell	0.53482134
92	MP0003879_abnormal_hair_cell	0.52954945
93	MP0003123_paternal_imprinting	0.51695162
94	MP0006035_abnormal_mitochondrial_morpho	0.50755764
95	MP0002697_abnormal_eye_size	0.47731724
96	MP0001666_abnormal_nutrient_absorption	0.46598935
97	MP0004215_abnormal_myocardial_fiber	0.45748720
98	MP0000313_abnormal_cell_death	0.44713743
99	MP0003787_abnormal_imprinting	0.42566413
100	MP0000750_abnormal_muscle_regeneration	0.39014202

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Male infertility (HP:0003251)	7.09343401
2	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	6.59951613
3	Malnutrition (HP:0004395)	5.02013752
4	Impulsivity (HP:0100710)	5.01201025
5	Septo-optic dysplasia (HP:0100842)	4.32532173
6	Abnormality of the septum pellucidum (HP:0007375)	4.10791515
7	Periauricular skin pits (HP:0100277)	4.10388490
8	Preauricular pit (HP:0004467)	4.10388490
9	Carpal bone hypoplasia (HP:0001498)	4.01821323
10	Abnormality of abdominal situs (HP:0011620)	4.00607215
11	Abdominal situs inversus (HP:0003363)	4.00607215
12	Hypercortisolism (HP:0001578)	3.94033439
13	Patent foramen ovale (HP:0001655)	3.85766388
14	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.69995742
15	Hypophosphatemic rickets (HP:0004912)	3.68546154
16	Chromsome breakage (HP:0040012)	3.67361287
17	Premature ovarian failure (HP:0008209)	3.60218722
18	Birth length less than 3rd percentile (HP:0003561)	3.58208766
19	Absent septum pellucidum (HP:0001331)	3.52729093
20	Double outlet right ventricle (HP:0001719)	3.46594302
21	Congenital malformation of the right heart (HP:0011723)	3.46594302
22	Aplasia/hypoplasia of the humerus (HP:0006507)	3.35228352
23	Aplasia/hypoplasia of the uterus (HP:0008684)	3.33275806
24	Midline defect of the nose (HP:0004122)	3.31795749
25	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.22012738
26	Abnormal pancreas size (HP:0012094)	3.17701014
27	Apathy (HP:0000741)	3.08925395
28	Abnormal umbilical cord blood vessels (HP:0011403)	3.06192161
29	Single umbilical artery (HP:0001195)	3.06192161
30	Abnormality of the fetal cardiovascular system (HP:0010948)	3.06192161
31	Ureteral duplication (HP:0000073)	3.05829564
32	Meckel diverticulum (HP:0002245)	2.99049204
33	Abnormality of the preputium (HP:0100587)	2.98344610
34	Muscle stiffness (HP:0003552)	2.93337192
35	Skin pits (HP:0100276)	2.84541105
36	Tetraparesis (HP:0002273)	2.83658632
37	Abnormality of the ileum (HP:0001549)	2.82668450
38	Mitral stenosis (HP:0001718)	2.79322124
39	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.77546782
40	Short tibia (HP:0005736)	2.75183186
41	Diminished motivation (HP:0000745)	2.72779418
42	Rhinitis (HP:0012384)	2.65008811
43	Hypoglycemic seizures (HP:0002173)	2.63787279
44	Infertility (HP:0000789)	2.60316225
45	Myokymia (HP:0002411)	2.55646559
46	Maternal diabetes (HP:0009800)	2.55181762
47	Sparse lateral eyebrow (HP:0005338)	2.45033092
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.42850656
49	Spinal cord lesions (HP:0100561)	2.42560989
50	Syringomyelia (HP:0003396)	2.42560989
51	Abnormality of the aortic arch (HP:0012303)	2.41861664
52	Absent radius (HP:0003974)	2.41758898
53	Hypoplastic scapulae (HP:0000882)	2.41382405
54	Aplasia/Hypoplasia of the scapulae (HP:0006713)	2.41382405
55	Osteomalacia (HP:0002749)	2.41196849
56	Hypoplasia of the uterus (HP:0000013)	2.40114203
57	Progressive sensorineural hearing impairment (HP:0000408)	2.38501957
58	Short humerus (HP:0005792)	2.34552790
59	Stenosis of the external auditory canal (HP:0000402)	2.32668064
60	Adrenal overactivity (HP:0002717)	2.31301611
61	Absent forearm bone (HP:0003953)	2.28067931
62	Aplasia involving forearm bones (HP:0009822)	2.28067931
63	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.27145171
64	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.26492111
65	Absent/shortened dynein arms (HP:0200106)	2.26492111
66	Abnormal number of incisors (HP:0011064)	2.26184781
67	Horseshoe kidney (HP:0000085)	2.25170811
68	Steatorrhea (HP:0002570)	2.24357739
69	Azoospermia (HP:0000027)	2.23726543
70	Concave nail (HP:0001598)	2.16960488
71	Urethral obstruction (HP:0000796)	2.15907607
72	Fused cervical vertebrae (HP:0002949)	2.14587545
73	Testicular atrophy (HP:0000029)	2.10435641
74	Fat malabsorption (HP:0002630)	2.10265104
75	Abnormality of the pubic bones (HP:0003172)	2.09574405
76	Reticulocytopenia (HP:0001896)	2.08798462
77	Cleft eyelid (HP:0000625)	2.07251525
78	Abnormality of chromosome stability (HP:0003220)	2.06951892
79	Oligodontia (HP:0000677)	2.06481437
80	Cortical visual impairment (HP:0100704)	2.06303019
81	Facial cleft (HP:0002006)	2.04255331
82	Constricted visual fields (HP:0001133)	2.04074653
83	Atresia of the external auditory canal (HP:0000413)	2.03624428
84	Abnormal biliary tract morphology (HP:0012440)	1.96644051
85	Increased circulating renin level (HP:0000848)	1.95993647
86	Abnormality of lateral ventricle (HP:0030047)	1.95261553
87	Microretrognathia (HP:0000308)	1.95099815
88	Sensory axonal neuropathy (HP:0003390)	1.94228801
89	Progressive hearing impairment (HP:0001730)	1.94200943
90	Gonadotropin excess (HP:0000837)	1.94189006
91	Hypergonadotropic hypogonadism (HP:0000815)	1.92698683
92	Abnormal ciliary motility (HP:0012262)	1.91814238
93	Absent thumb (HP:0009777)	1.90274866
94	Dysautonomia (HP:0002459)	1.90140649
95	Attenuation of retinal blood vessels (HP:0007843)	1.89603907
96	Hyperglycemia (HP:0003074)	1.89207301
97	Short thumb (HP:0009778)	1.88725607
98	Chronic sinusitis (HP:0011109)	1.88521821
99	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88027602
100	Glossoptosis (HP:0000162)	1.85221989

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS2	5.46012269
2	SRPK1	4.12840941
3	TESK2	4.09930209
4	CDK9	3.71953993
5	BUB1	3.49574388
6	DYRK3	3.45499459
7	TRIM28	3.05516365
8	NEK6	2.91001605
9	CDC7	2.70587932
10	CDK12	2.56637981
11	PLK1	2.53050388
12	PIM2	2.41968840
13	TAOK3	2.40969063
14	AURKB	1.95313205
15	PLK3	1.93874590
16	BRSK1	1.90961504
17	PBK	1.81883574
18	GSK3A	1.66775262
19	RAF1	1.65119173
20	AURKA	1.62917371
21	WNK3	1.60079707
22	STK16	1.56834719
23	MARK3	1.54921050
24	PIM1	1.52428982
25	PRKCI	1.52281276
26	CDK7	1.49756151
27	MAP3K9	1.46929531
28	CHEK1	1.44215198
29	PDK2	1.39434815
30	TTK	1.31972760
31	CSNK1E	1.31527767
32	MELK	1.25851974
33	BRD4	1.19039631
34	TNIK	1.14941164
35	PAK2	1.13350165
36	BRSK2	1.09457917
37	NEK2	1.05562585
38	CDK19	0.99831163
39	CDK2	0.98308283
40	PLK4	0.96469424
41	MTOR	0.95259846
42	CDK1	0.90472062
43	WNK1	0.87485104
44	CHEK2	0.86562784
45	MAP3K5	0.86367160
46	CSNK2A2	0.81208047
47	CSNK2A1	0.75664201
48	ATR	0.74018537
49	STK4	0.72827825
50	PKN1	0.71562387
51	ATM	0.69897140
52	LRRK2	0.69077642
53	PAK1	0.67813027
54	TBK1	0.65905605
55	STK3	0.64136981
56	PRKG1	0.62147741
57	PRKACB	0.59532498
58	NTRK3	0.59339553
59	WEE1	0.58167911
60	GSK3B	0.57620902
61	MAP3K4	0.57403639
62	CSNK1D	0.52767330
63	ZAK	0.51111482
64	MAPK1	0.50161420
65	TAOK2	0.48175916
66	MAPK11	0.47338185
67	MAPK14	0.47335982
68	TIE1	0.47018826
69	DYRK1A	0.46428334
70	TESK1	0.45731846
71	TSSK6	0.44608238
72	STK24	0.43357282
73	TLK1	0.41098706
74	MAPK10	0.39864115
75	RPS6KA1	0.39173648
76	CDK3	0.37262234
77	VRK1	0.36610819
78	CDK5	0.36300195
79	PRKAA1	0.34843213
80	PRKD1	0.33306619
81	KSR1	0.33173283
82	CLK1	0.31651290
83	DMPK	0.29929374
84	MAP3K10	0.29582198
85	KDR	0.29495919
86	PRPF4B	0.28163050
87	PRKACA	0.27332192
88	MAP3K8	0.26884208
89	TAF1	0.25748575
90	AKT1	0.23624585
91	MAP3K6	0.23398394
92	STK10	0.22458925
93	TEC	0.21094897
94	CAMK1	0.21015022
95	AKT2	0.20814856
96	ABL2	0.20724527
97	CSNK1A1	0.20296316
98	PLK2	0.20146959
99	MAPK4	0.19074676
100	MAPK8	0.18620956

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	6.21483937
2	Regulation of autophagy_Homo sapiens_hsa04140	4.17175645
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.94699950
4	mRNA surveillance pathway_Homo sapiens_hsa03015	3.87649295
5	Cell cycle_Homo sapiens_hsa04110	3.50962919
6	p53 signaling pathway_Homo sapiens_hsa04115	3.33236912
7	RNA transport_Homo sapiens_hsa03013	3.11634519
8	RNA polymerase_Homo sapiens_hsa03020	3.03232775
9	Oocyte meiosis_Homo sapiens_hsa04114	2.63578007
10	Spliceosome_Homo sapiens_hsa03040	2.52872101
11	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.16795249
12	Ribosome_Homo sapiens_hsa03010	2.15663143
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.95123345
14	Mismatch repair_Homo sapiens_hsa03430	1.92814245
15	Homologous recombination_Homo sapiens_hsa03440	1.91824672
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.84870774
17	Caffeine metabolism_Homo sapiens_hsa00232	1.82765306
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.76938113
19	Taste transduction_Homo sapiens_hsa04742	1.65680433
20	Folate biosynthesis_Homo sapiens_hsa00790	1.63981939
21	MicroRNAs in cancer_Homo sapiens_hsa05206	1.59203488
22	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.43618965
23	Sulfur metabolism_Homo sapiens_hsa00920	1.39500076
24	Fatty acid elongation_Homo sapiens_hsa00062	1.32730578
25	RNA degradation_Homo sapiens_hsa03018	1.26922364
26	Viral carcinogenesis_Homo sapiens_hsa05203	1.16177972
27	Base excision repair_Homo sapiens_hsa03410	1.13394326
28	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.08288622
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.04151188
30	DNA replication_Homo sapiens_hsa03030	1.02821417
31	Small cell lung cancer_Homo sapiens_hsa05222	1.00694967
32	Herpes simplex infection_Homo sapiens_hsa05168	1.00244999
33	Hepatitis B_Homo sapiens_hsa05161	0.98767117
34	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97811202
35	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.96292045
36	Purine metabolism_Homo sapiens_hsa00230	0.95404258
37	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.94259050
38	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.93468160
39	Huntingtons disease_Homo sapiens_hsa05016	0.92245813
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90417707
41	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90353218
42	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.89531169
43	Wnt signaling pathway_Homo sapiens_hsa04310	0.89152519
44	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.86846923
45	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.86540520
46	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.86268787
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.83328750
48	Nucleotide excision repair_Homo sapiens_hsa03420	0.78097262
49	Arginine and proline metabolism_Homo sapiens_hsa00330	0.76125146
50	Acute myeloid leukemia_Homo sapiens_hsa05221	0.74975501
51	Nicotine addiction_Homo sapiens_hsa05033	0.69633400
52	FoxO signaling pathway_Homo sapiens_hsa04068	0.69618093
53	AMPK signaling pathway_Homo sapiens_hsa04152	0.68766939
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59423198
55	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57463542
56	Renal cell carcinoma_Homo sapiens_hsa05211	0.55755277
57	Prostate cancer_Homo sapiens_hsa05215	0.55566830
58	Bile secretion_Homo sapiens_hsa04976	0.54806687
59	Insulin secretion_Homo sapiens_hsa04911	0.54527131
60	Olfactory transduction_Homo sapiens_hsa04740	0.53924807
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.50902134
62	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.49534784
63	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.48935563
64	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42600611
65	ABC transporters_Homo sapiens_hsa02010	0.41022433
66	Hippo signaling pathway_Homo sapiens_hsa04390	0.39220483
67	Protein digestion and absorption_Homo sapiens_hsa04974	0.38484681
68	Alcoholism_Homo sapiens_hsa05034	0.38296313
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.38168854
70	Mineral absorption_Homo sapiens_hsa04978	0.34694928
71	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.33993768
72	Circadian rhythm_Homo sapiens_hsa04710	0.32020084
73	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.30400711
74	Influenza A_Homo sapiens_hsa05164	0.29875436
75	GABAergic synapse_Homo sapiens_hsa04727	0.28331254
76	Pathways in cancer_Homo sapiens_hsa05200	0.28031337
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.27240586
78	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.26527471
79	Colorectal cancer_Homo sapiens_hsa05210	0.25043904
80	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.23360530
81	Legionellosis_Homo sapiens_hsa05134	0.23301416
82	Adherens junction_Homo sapiens_hsa04520	0.20865667
83	Amphetamine addiction_Homo sapiens_hsa05031	0.20450491
84	mTOR signaling pathway_Homo sapiens_hsa04150	0.20028218
85	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.19437538
86	Glutathione metabolism_Homo sapiens_hsa00480	0.19125781
87	Endometrial cancer_Homo sapiens_hsa05213	0.18747089
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.14677467
89	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.14619396
90	Morphine addiction_Homo sapiens_hsa05032	0.13193670
91	Tight junction_Homo sapiens_hsa04530	0.10950444
92	Measles_Homo sapiens_hsa05162	0.10287799
93	Parkinsons disease_Homo sapiens_hsa05012	0.09180004
94	HTLV-I infection_Homo sapiens_hsa05166	0.08704336
95	MAPK signaling pathway_Homo sapiens_hsa04010	0.07836916
96	Sphingolipid metabolism_Homo sapiens_hsa00600	0.06820033
97	Pancreatic secretion_Homo sapiens_hsa04972	0.04387413
98	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.02742553
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.02568454
100	Insulin signaling pathway_Homo sapiens_hsa04910	0.02259279

HNRNPCL3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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