ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of acrosome reaction (GO:0060046)	6.48593480
2	multicellular organism reproduction (GO:0032504)	6.06766789
3	regulation of cytokine production involved in inflammatory response (GO:1900015)	5.45986641
4	positive regulation of uterine smooth muscle contraction (GO:0070474)	5.28735388
5	positive regulation of prostaglandin secretion (GO:0032308)	5.21490114
6	regulation of female gonad development (GO:2000194)	4.70785590
7	sleep (GO:0030431)	4.64919603
8	regulation of prostaglandin secretion (GO:0032306)	4.34821832
9	positive regulation of humoral immune response (GO:0002922)	4.31545808
10	protein kinase C signaling (GO:0070528)	4.20603549
11	aggressive behavior (GO:0002118)	4.17859742
12	rRNA methylation (GO:0031167)	4.13498302
13	regulation of female receptivity (GO:0045924)	4.11444097
14	reproduction (GO:0000003)	4.09515798
15	rRNA modification (GO:0000154)	4.07084586
16	regulation of uterine smooth muscle contraction (GO:0070472)	4.00537345
17	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	38.0610996
18	regulation of retinoic acid receptor signaling pathway (GO:0048385)	31.8739082
19	maturation of SSU-rRNA (GO:0030490)	3.90368837
20	regulation of penile erection (GO:0060405)	3.72442557
21	hyperosmotic salinity response (GO:0042538)	3.69836232
22	chaperone-mediated protein transport (GO:0072321)	3.65007694
23	female mating behavior (GO:0060180)	3.49928791
24	drinking behavior (GO:0042756)	3.47901858
25	positive regulation of catecholamine secretion (GO:0033605)	3.34527189
26	glycine transport (GO:0015816)	3.33134244
27	binding of sperm to zona pellucida (GO:0007339)	3.32775671
28	positive regulation of icosanoid secretion (GO:0032305)	3.31851495
29	oocyte development (GO:0048599)	3.27023160
30	DNA deamination (GO:0045006)	3.26509178
31	positive regulation of fatty acid transport (GO:2000193)	3.22751464
32	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.22486605
33	positive regulation of digestive system process (GO:0060456)	3.18389645
34	termination of RNA polymerase III transcription (GO:0006386)	3.11267249
35	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.11267249
36	negative regulation of reproductive process (GO:2000242)	3.10465834
37	negative regulation of digestive system process (GO:0060457)	3.06603195
38	response to acidic pH (GO:0010447)	3.06006163
39	sperm-egg recognition (GO:0035036)	3.04931771
40	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.04398523
41	male meiosis I (GO:0007141)	3.02848064
42	proteasome assembly (GO:0043248)	2.80776608
43	single fertilization (GO:0007338)	2.76905395
44	protein K6-linked ubiquitination (GO:0085020)	2.75431330
45	maternal behavior (GO:0042711)	2.70224403
46	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.64839543
47	parental behavior (GO:0060746)	2.63516525
48	regulation of hypersensitivity (GO:0002883)	2.63323731
49	regulation of norepinephrine secretion (GO:0014061)	2.56796312
50	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.56492774
51	cellular response to pH (GO:0071467)	2.55547551
52	protein deneddylation (GO:0000338)	2.54212404
53	meiosis I (GO:0007127)	2.48975896
54	cell-cell recognition (GO:0009988)	2.48233102
55	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.47155464
56	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.45779785
57	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.45779785
58	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.45135207
59	positive regulation of reproductive process (GO:2000243)	2.44144290
60	translational termination (GO:0006415)	2.43816320
61	transcription from mitochondrial promoter (GO:0006390)	2.40711376
62	viral transcription (GO:0019083)	2.38594528
63	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.38423272
64	regulation of icosanoid secretion (GO:0032303)	2.33313635
65	ribosomal small subunit biogenesis (GO:0042274)	2.28193879
66	pseudouridine synthesis (GO:0001522)	2.21264019
67	telomere maintenance via telomere lengthening (GO:0010833)	2.20846989
68	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.20405800
69	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.20405800
70	NADH dehydrogenase complex assembly (GO:0010257)	2.20405800
71	translational elongation (GO:0006414)	2.19808760
72	regulation of DNA methylation (GO:0044030)	2.19480354
73	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.17157486
74	termination of RNA polymerase I transcription (GO:0006363)	2.15577093
75	rRNA processing (GO:0006364)	2.12939642
76	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.12747900
77	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.12432025
78	fertilization (GO:0009566)	2.12070508
79	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.12054065
80	7-methylguanosine mRNA capping (GO:0006370)	2.10863696
81	cotranslational protein targeting to membrane (GO:0006613)	2.10576741
82	translational initiation (GO:0006413)	2.07598910
83	response to food (GO:0032094)	2.07537740
84	transcription elongation from RNA polymerase II promoter (GO:0006368)	2.07507925
85	respiratory chain complex IV assembly (GO:0008535)	2.06805066
86	ribosomal small subunit assembly (GO:0000028)	2.06686150
87	mitochondrial RNA metabolic process (GO:0000959)	2.05903676
88	rRNA metabolic process (GO:0016072)	2.05865655
89	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.05206901
90	protein targeting to ER (GO:0045047)	2.05074524
91	RNA capping (GO:0036260)	2.05056645
92	7-methylguanosine RNA capping (GO:0009452)	2.05056645
93	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.04500924
94	DNA-templated transcription, termination (GO:0006353)	2.03138595
95	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.02260275
96	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.00889689
97	positive regulation of organic acid transport (GO:0032892)	2.00234883
98	positive regulation of protein homooligomerization (GO:0032464)	1.99633615
99	DNA-templated transcription, elongation (GO:0006354)	1.99402556
100	ribosomal large subunit biogenesis (GO:0042273)	1.98247626

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.82596866
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.65043938
3	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.47480178
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.88129277
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.78636493
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.78102102
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.35157953
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.99058093
9	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.90366065
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82406381
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.80266662
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.68573167
13	MYC_18940864_ChIP-ChIP_HL60_Human	2.53658595
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.50233825
15	RBPJ_21746931_ChIP-Seq_IB4_Human	2.36326344
16	ETV1_20927104_ChIP-Seq_GIST48_Human	2.36164932
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.36025835
18	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.30216338
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.25934915
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.24914617
21	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.19512898
22	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.19512898
23	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.19512898
24	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.11106755
25	NFYB_21822215_ChIP-Seq_K562_Human	2.10322740
26	PHF8_20622853_ChIP-Seq_HELA_Human	2.05953076
27	VDR_22108803_ChIP-Seq_LS180_Human	2.05596084
28	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	2.02773529
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.02600502
30	FOXP3_21729870_ChIP-Seq_TREG_Human	2.02070926
31	TBL1_22424771_ChIP-Seq_293T_Human	1.97557292
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.95678084
33	EZH2_22144423_ChIP-Seq_EOC_Human	1.92609203
34	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.89636420
35	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.82497611
36	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.81715488
37	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.75650526
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69690759
39	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.61788974
40	GABP_19822575_ChIP-Seq_HepG2_Human	1.59582370
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.57381700
42	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.52657014
43	NANOG_20526341_ChIP-Seq_ESCs_Human	1.50552733
44	TTF2_22483619_ChIP-Seq_HELA_Human	1.49425120
45	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48430596
46	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.46966134
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.46040320
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45066437
49	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.44297568
50	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.43177631
51	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.42099485
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.40173227
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.40147098
54	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.39177209
55	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.37958885
56	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.35977647
57	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.30996958
58	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.30844093
59	NFYA_21822215_ChIP-Seq_K562_Human	1.28644557
60	IGF1R_20145208_ChIP-Seq_DFB_Human	1.25001430
61	STAT1_20625510_ChIP-Seq_HELA_Human	1.23564629
62	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22283181
63	XRN2_22483619_ChIP-Seq_HELA_Human	1.20847530
64	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.19371161
65	SOX2_21211035_ChIP-Seq_LN229_Human	1.18847923
66	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.18144271
67	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.17926818
68	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.17779194
69	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.17626637
70	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.17455507
71	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.17010089
72	NCOR_22424771_ChIP-Seq_293T_Human	1.16383682
73	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.14297714
74	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.10674663
75	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10006033
76	GATA3_26560356_Chip-Seq_TH2_Human	1.09548247
77	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.08043195
78	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.08005625
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.07985372
80	E2F1_20622854_ChIP-Seq_HELA_Human	1.07047026
81	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.05842405
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02971409
83	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99603670
84	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99457303
85	BCAT_22108803_ChIP-Seq_LS180_Human	0.99313919
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98778583
87	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.97570902
88	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96292711
89	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.96092660
90	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.95024973
91	OCT4_20526341_ChIP-Seq_ESCs_Human	0.93773298
92	RAC3_21632823_ChIP-Seq_H3396_Human	0.92535734
93	CTCF_20526341_ChIP-Seq_ESCs_Human	0.91353893
94	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.88850311
95	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.87889845
96	TAF2_19829295_ChIP-Seq_ESCs_Human	0.86988689
97	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.86470680
98	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.86075040
99	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.85925343
100	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.85486804

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.40650928
2	MP0003718_maternal_effect	3.82571199
3	MP0008877_abnormal_DNA_methylation	3.61083596
4	MP0001986_abnormal_taste_sensitivity	3.35331800
5	MP0002254_reproductive_system_inflammat	3.24841456
6	MP0009379_abnormal_foot_pigmentation	3.19820956
7	MP0003195_calcinosis	3.11224202
8	MP0005410_abnormal_fertilization	2.95424930
9	MP0006276_abnormal_autonomic_nervous	2.75580443
10	MP0005360_urolithiasis	2.42073590
11	MP0008058_abnormal_DNA_repair	2.29957057
12	MP0004142_abnormal_muscle_tone	2.26429817
13	MP0003693_abnormal_embryo_hatching	2.26241112
14	MP0000372_irregular_coat_pigmentation	2.13655710
15	MP0002277_abnormal_respiratory_mucosa	2.12163148
16	MP0001929_abnormal_gametogenesis	2.10091502
17	MP0002163_abnormal_gland_morphology	2.07946533
18	MP0005423_abnormal_somatic_nervous	2.06635469
19	MP0005389_reproductive_system_phenotype	1.95596735
20	MP0002210_abnormal_sex_determination	1.91753566
21	MP0005379_endocrine/exocrine_gland_phen	1.91729104
22	MP0002160_abnormal_reproductive_system	1.90506911
23	MP0001529_abnormal_vocalization	1.89484714
24	MP0002102_abnormal_ear_morphology	1.84128511
25	MP0002138_abnormal_hepatobiliary_system	1.78075030
26	MP0005646_abnormal_pituitary_gland	1.75429533
27	MP0005395_other_phenotype	1.74735850
28	MP0009333_abnormal_splenocyte_physiolog	1.71210925
29	MP0005647_abnormal_sex_gland	1.62907755
30	MP0002736_abnormal_nociception_after	1.59772419
31	MP0001119_abnormal_female_reproductive	1.58429967
32	MP0000653_abnormal_sex_gland	1.56400059
33	MP0005499_abnormal_olfactory_system	1.55346629
34	MP0005394_taste/olfaction_phenotype	1.55346629
35	MP0003646_muscle_fatigue	1.53629259
36	MP0001881_abnormal_mammary_gland	1.52918998
37	MP0005671_abnormal_response_to	1.50649829
38	MP0001919_abnormal_reproductive_system	1.48554831
39	MP0004957_abnormal_blastocyst_morpholog	1.48180379
40	MP0001346_abnormal_lacrimal_gland	1.39687718
41	MP0005551_abnormal_eye_electrophysiolog	1.39572459
42	MP0009840_abnormal_foam_cell	1.38926181
43	MP0003866_abnormal_defecation	1.34982419
44	MP0006072_abnormal_retinal_apoptosis	1.34183342
45	MP0001502_abnormal_circadian_rhythm	1.31070857
46	MP0003699_abnormal_female_reproductive	1.30904072
47	MP0008932_abnormal_embryonic_tissue	1.29612440
48	MP0005075_abnormal_melanosome_morpholog	1.27346262
49	MP0003186_abnormal_redox_activity	1.26411414
50	MP0003786_premature_aging	1.25879074
51	MP0001968_abnormal_touch/_nociception	1.24799524
52	MP0004019_abnormal_vitamin_homeostasis	1.23269035
53	MP0003136_yellow_coat_color	1.20602137
54	MP0008789_abnormal_olfactory_epithelium	1.19782350
55	MP0010094_abnormal_chromosome_stability	1.19693319
56	MP0003787_abnormal_imprinting	1.19484748
57	MP0003111_abnormal_nucleus_morphology	1.17552691
58	MP0001145_abnormal_male_reproductive	1.17497978
59	MP0003283_abnormal_digestive_organ	1.15983729
60	MP0003077_abnormal_cell_cycle	1.08060721
61	MP0003698_abnormal_male_reproductive	1.07731452
62	MP0002127_abnormal_cardiovascular_syste	1.07100476
63	MP0001984_abnormal_olfaction	1.04534826
64	MP0002161_abnormal_fertility/fecundity	1.02168210
65	MP0001293_anophthalmia	0.99746858
66	MP0001440_abnormal_grooming_behavior	0.99102861
67	MP0006036_abnormal_mitochondrial_physio	0.97020389
68	MP0003880_abnormal_central_pattern	0.96416711
69	MP0003252_abnormal_bile_duct	0.93439912
70	MP0001486_abnormal_startle_reflex	0.89026667
71	MP0002272_abnormal_nervous_system	0.87913840
72	MP0005645_abnormal_hypothalamus_physiol	0.83942726
73	MP0010368_abnormal_lymphatic_system	0.83931420
74	MP0004145_abnormal_muscle_electrophysio	0.83175700
75	MP0001764_abnormal_homeostasis	0.82641901
76	MP0004215_abnormal_myocardial_fiber	0.82381063
77	MP0002876_abnormal_thyroid_physiology	0.81349255
78	MP0003950_abnormal_plasma_membrane	0.80974405
79	MP0002938_white_spotting	0.79105296
80	MP0005253_abnormal_eye_physiology	0.75532242
81	MP0001905_abnormal_dopamine_level	0.74482722
82	MP0000685_abnormal_immune_system	0.74229705
83	MP0000631_abnormal_neuroendocrine_gland	0.72412582
84	MP0008875_abnormal_xenobiotic_pharmacok	0.71682791
85	MP0010307_abnormal_tumor_latency	0.69563066
86	MP0002148_abnormal_hypersensitivity_rea	0.64531533
87	MP0009384_cardiac_valve_regurgitation	0.63080418
88	MP0001873_stomach_inflammation	0.62785298
89	MP0005085_abnormal_gallbladder_physiolo	0.62701476
90	MP0004885_abnormal_endolymph	0.61852223
91	MP0002229_neurodegeneration	0.61079861
92	MP0004742_abnormal_vestibular_system	0.61025026
93	MP0005084_abnormal_gallbladder_morpholo	0.60675519
94	MP0004147_increased_porphyrin_level	0.57391620
95	MP0008872_abnormal_physiological_respon	0.56048945
96	MP0005310_abnormal_salivary_gland	0.55585734
97	MP0001501_abnormal_sleep_pattern	0.54364122
98	MP0008995_early_reproductive_senescence	0.53980850
99	MP0003936_abnormal_reproductive_system	0.51717328
100	MP0001672_abnormal_embryogenesis/_devel	0.50175726

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Male infertility (HP:0003251)	4.71920033
2	Premature ovarian failure (HP:0008209)	4.32603863
3	Aplasia/hypoplasia of the uterus (HP:0008684)	4.31964018
4	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.93795710
5	Hypoplasia of the fovea (HP:0007750)	3.93795710
6	Rhinitis (HP:0012384)	3.83486182
7	Malnutrition (HP:0004395)	3.79728973
8	Hypoplasia of the uterus (HP:0000013)	3.71557740
9	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.35813174
10	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.15267116
11	Abnormality of the fovea (HP:0000493)	3.05417967
12	Constricted visual fields (HP:0001133)	3.00526560
13	Attenuation of retinal blood vessels (HP:0007843)	2.98135297
14	3-Methylglutaconic aciduria (HP:0003535)	2.97076835
15	Carpal bone hypoplasia (HP:0001498)	2.93559920
16	Reticulocytopenia (HP:0001896)	2.91225562
17	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.86031046
18	Pendular nystagmus (HP:0012043)	2.81639331
19	Acute necrotizing encephalopathy (HP:0006965)	2.78091702
20	Sensory axonal neuropathy (HP:0003390)	2.75847595
21	Anterior segment dysgenesis (HP:0007700)	2.63691389
22	Abnormal mitochondria in muscle tissue (HP:0008316)	2.61024557
23	Acute encephalopathy (HP:0006846)	2.58968691
24	Infertility (HP:0000789)	2.58843008
25	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.58727614
26	Abnormality of alanine metabolism (HP:0010916)	2.58727614
27	Hyperalaninemia (HP:0003348)	2.58727614
28	Steatorrhea (HP:0002570)	2.58330742
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.57553886
30	Increased CSF lactate (HP:0002490)	2.53908973
31	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.51867323
32	Abnormal protein N-linked glycosylation (HP:0012347)	2.51867323
33	Abnormal protein glycosylation (HP:0012346)	2.51867323
34	Abnormal glycosylation (HP:0012345)	2.51867323
35	Fused cervical vertebrae (HP:0002949)	2.50317186
36	Hypophosphatemic rickets (HP:0004912)	2.47602621
37	Pancreatic cysts (HP:0001737)	2.41060754
38	Increased serum lactate (HP:0002151)	2.41051590
39	Congenital ichthyosiform erythroderma (HP:0007431)	2.40243018
40	IgG deficiency (HP:0004315)	2.39839763
41	Abolished electroretinogram (ERG) (HP:0000550)	2.38394199
42	Aplasia/Hypoplasia of the macula (HP:0008059)	2.37160158
43	Dyschromatopsia (HP:0007641)	2.34837460
44	Hypergonadotropic hypogonadism (HP:0000815)	2.32776767
45	Brittle hair (HP:0002299)	2.31898119
46	Methylmalonic acidemia (HP:0002912)	2.29773379
47	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.26721713
48	Progressive macrocephaly (HP:0004481)	2.21585631
49	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.20444704
50	Cleft eyelid (HP:0000625)	2.20334342
51	Central scotoma (HP:0000603)	2.17022200
52	Poor suck (HP:0002033)	2.16998769
53	Molar tooth sign on MRI (HP:0002419)	2.16336752
54	Abnormality of midbrain morphology (HP:0002418)	2.16336752
55	Optic disc pallor (HP:0000543)	2.16063915
56	Mitochondrial inheritance (HP:0001427)	2.15356105
57	Progressive inability to walk (HP:0002505)	2.07799998
58	Type 2 muscle fiber atrophy (HP:0003554)	2.07341368
59	Short tibia (HP:0005736)	2.04709721
60	Poor head control (HP:0002421)	2.04647564
61	Delayed CNS myelination (HP:0002188)	2.03631855
62	Absent thumb (HP:0009777)	2.02829695
63	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.02389787
64	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.02389787
65	Abnormality of the septum pellucidum (HP:0007375)	2.01709323
66	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.00591763
67	Progressive microcephaly (HP:0000253)	1.98870482
68	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.98563384
69	Abnormality of the ileum (HP:0001549)	1.95772964
70	Fat malabsorption (HP:0002630)	1.95545589
71	Nephronophthisis (HP:0000090)	1.94875866
72	Limb dystonia (HP:0002451)	1.89883941
73	Bony spicule pigmentary retinopathy (HP:0007737)	1.89102737
74	Macular degeneration (HP:0000608)	1.88814582
75	Abnormal number of erythroid precursors (HP:0012131)	1.88062325
76	Meckel diverticulum (HP:0002245)	1.87603455
77	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.85763767
78	Multiple enchondromatosis (HP:0005701)	1.84961987
79	Methylmalonic aciduria (HP:0012120)	1.84775446
80	Muscle stiffness (HP:0003552)	1.83764538
81	Reduced antithrombin III activity (HP:0001976)	1.83729011
82	Abnormality of cells of the erythroid lineage (HP:0012130)	1.81405050
83	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.80749566
84	Congenital stationary night blindness (HP:0007642)	1.80449951
85	Esotropia (HP:0000565)	1.80359366
86	Myokymia (HP:0002411)	1.80016016
87	Type I transferrin isoform profile (HP:0003642)	1.77441847
88	Macrocytic anemia (HP:0001972)	1.77341572
89	Retinal atrophy (HP:0001105)	1.77032192
90	Absent septum pellucidum (HP:0001331)	1.76193795
91	Sparse eyelashes (HP:0000653)	1.75763264
92	Lethargy (HP:0001254)	1.75133944
93	Lactic acidosis (HP:0003128)	1.75124416
94	Renal cortical cysts (HP:0000803)	1.74855590
95	Parakeratosis (HP:0001036)	1.74687979
96	Hepatic necrosis (HP:0002605)	1.73415246
97	Stomatitis (HP:0010280)	1.73291194
98	Progressive muscle weakness (HP:0003323)	1.72836689
99	Male pseudohermaphroditism (HP:0000037)	1.72498233
100	Abnormality of eosinophils (HP:0001879)	1.72300567

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	4.11459592
2	TESK2	4.11424583
3	BUB1	3.57996058
4	CDK19	3.50899482
5	SRPK1	3.43346775
6	EIF2AK3	3.11334504
7	VRK2	2.98023755
8	STK16	2.97868713
9	PDK2	2.82481850
10	BRSK2	2.59345270
11	ZAK	2.49134181
12	NEK6	2.42328049
13	TLK1	2.39619247
14	TXK	2.17774024
15	MUSK	2.06430483
16	FRK	1.96500029
17	MAP3K9	1.76348346
18	NUAK1	1.63179162
19	TAOK3	1.46795235
20	PLK3	1.41614627
21	BRSK1	1.36694860
22	VRK1	1.30939912
23	NME1	1.28591967
24	BCR	1.25899056
25	ADRBK2	1.23043984
26	BCKDK	1.22384159
27	WNK3	1.22147376
28	BMPR1B	1.22084805
29	PINK1	1.20906083
30	PLK1	1.18432001
31	MARK3	1.16396974
32	PRKCI	1.15572657
33	KDR	1.12772520
34	GRK1	1.11736871
35	TSSK6	1.09196226
36	PLK4	1.03191999
37	AURKB	0.96981206
38	LATS2	0.93175996
39	MAP4K2	0.91945490
40	EIF2AK1	0.89792736
41	LRRK2	0.89737939
42	LIMK1	0.82138892
43	STK3	0.81272760
44	AURKA	0.80713924
45	IKBKB	0.80080632
46	EIF2AK2	0.79696630
47	PKN1	0.79072507
48	ACVR1B	0.75860478
49	ATR	0.74469646
50	NEK2	0.71164233
51	OXSR1	0.64703859
52	CSNK1G1	0.64388772
53	FES	0.63989447
54	CSNK2A1	0.61850707
55	CCNB1	0.61717820
56	MAP3K13	0.61357673
57	CSNK2A2	0.59587794
58	WNK4	0.59420032
59	MAP3K12	0.55541270
60	CHEK1	0.53891154
61	MST4	0.52162252
62	WNK1	0.51426848
63	CSNK1E	0.50888702
64	PLK2	0.49491935
65	STK38L	0.49319417
66	GRK6	0.48948776
67	GRK5	0.48437936
68	BMPR2	0.47917216
69	CDK7	0.47133091
70	ADRBK1	0.46617275
71	CLK1	0.46085398
72	CDC7	0.44384426
73	PIK3CG	0.39489169
74	CHEK2	0.39455032
75	INSRR	0.38343644
76	RPS6KA5	0.36723551
77	AKT2	0.36450862
78	STK10	0.36253828
79	PAK1	0.35106223
80	ARAF	0.34966528
81	CSNK1G3	0.32638429
82	TIE1	0.32557822
83	TAOK1	0.32458218
84	GSK3A	0.28663536
85	PRKCG	0.28220344
86	TTK	0.27731026
87	CSNK1A1	0.27542786
88	LYN	0.26683715
89	PRKCE	0.26327444
90	KIT	0.25833202
91	MAP3K5	0.25195354
92	WEE1	0.25194490
93	STK4	0.24443478
94	MAPKAPK2	0.24165182
95	CSNK1A1L	0.23006760
96	FER	0.22342020
97	IGF1R	0.21347347
98	ERBB3	0.21236097
99	DYRK2	0.20984894
100	IKBKE	0.20837951

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	4.60930536
2	Ribosome_Homo sapiens_hsa03010	3.98703452
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.94161750
4	RNA polymerase_Homo sapiens_hsa03020	3.91832642
5	Proteasome_Homo sapiens_hsa03050	2.67551610
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.28067352
7	Spliceosome_Homo sapiens_hsa03040	2.24378823
8	Folate biosynthesis_Homo sapiens_hsa00790	2.21820267
9	RNA transport_Homo sapiens_hsa03013	2.19073148
10	mRNA surveillance pathway_Homo sapiens_hsa03015	2.01115710
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.89350081
12	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.89337072
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.87603970
14	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.87542693
15	Protein export_Homo sapiens_hsa03060	1.84237097
16	Taste transduction_Homo sapiens_hsa04742	1.83302387
17	Parkinsons disease_Homo sapiens_hsa05012	1.75105372
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.74339150
19	Regulation of autophagy_Homo sapiens_hsa04140	1.62059820
20	RNA degradation_Homo sapiens_hsa03018	1.56575046
21	Propanoate metabolism_Homo sapiens_hsa00640	1.53989194
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.53419033
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.45349652
24	Homologous recombination_Homo sapiens_hsa03440	1.39537329
25	Cell cycle_Homo sapiens_hsa04110	1.39418417
26	Huntingtons disease_Homo sapiens_hsa05016	1.34627981
27	Non-homologous end-joining_Homo sapiens_hsa03450	1.33378817
28	Base excision repair_Homo sapiens_hsa03410	1.30162864
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.25611068
30	Asthma_Homo sapiens_hsa05310	1.24120483
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24048902
32	Phototransduction_Homo sapiens_hsa04744	1.19853321
33	Purine metabolism_Homo sapiens_hsa00230	1.15143575
34	Oocyte meiosis_Homo sapiens_hsa04114	1.15023056
35	p53 signaling pathway_Homo sapiens_hsa04115	1.14907661
36	Fatty acid elongation_Homo sapiens_hsa00062	1.13997521
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.11676905
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11110003
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.10822769
40	Olfactory transduction_Homo sapiens_hsa04740	1.02220417
41	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.00826436
42	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.00139344
43	Selenocompound metabolism_Homo sapiens_hsa00450	0.98905081
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.98185219
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.94986099
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.94579198
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.94041517
48	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.90700198
49	Mismatch repair_Homo sapiens_hsa03430	0.89571267
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.87696989
51	Sulfur metabolism_Homo sapiens_hsa00920	0.86734965
52	Pyruvate metabolism_Homo sapiens_hsa00620	0.82573892
53	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.81816191
54	Graft-versus-host disease_Homo sapiens_hsa05332	0.79943297
55	Allograft rejection_Homo sapiens_hsa05330	0.77235730
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76693627
57	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.76356760
58	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.75741036
59	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.73746524
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.73473851
61	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.73303688
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.72090830
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.72022549
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.70536152
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.69169985
66	Steroid biosynthesis_Homo sapiens_hsa00100	0.67791042
67	Herpes simplex infection_Homo sapiens_hsa05168	0.66381133
68	DNA replication_Homo sapiens_hsa03030	0.66184921
69	Alzheimers disease_Homo sapiens_hsa05010	0.64933589
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.64806486
71	Rheumatoid arthritis_Homo sapiens_hsa05323	0.62910035
72	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60846051
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59425710
74	Retinol metabolism_Homo sapiens_hsa00830	0.55364813
75	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.53623808
76	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.53513509
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.52227005
78	Metabolic pathways_Homo sapiens_hsa01100	0.51385338
79	Serotonergic synapse_Homo sapiens_hsa04726	0.48621110
80	Butanoate metabolism_Homo sapiens_hsa00650	0.46847229
81	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.46529667
82	Mineral absorption_Homo sapiens_hsa04978	0.41856225
83	ABC transporters_Homo sapiens_hsa02010	0.41686354
84	Caffeine metabolism_Homo sapiens_hsa00232	0.41523198
85	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.39445009
86	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.36271498
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33639841
88	Peroxisome_Homo sapiens_hsa04146	0.31420890
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30720364
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.28617895
91	Legionellosis_Homo sapiens_hsa05134	0.27259211
92	Glutathione metabolism_Homo sapiens_hsa00480	0.25597632
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.25005883
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.24912144
95	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.23648835
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.23449927
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.23137757
98	Primary immunodeficiency_Homo sapiens_hsa05340	0.23120076
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.23049453
100	Viral carcinogenesis_Homo sapiens_hsa05203	0.22957916

HNRNPCL4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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