HNRNPCP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of protein kinase A signaling (GO:0010738)9.56617586
2detection of light stimulus involved in sensory perception (GO:0050962)8.96579754
3detection of light stimulus involved in visual perception (GO:0050908)8.96579754
4cyclic nucleotide catabolic process (GO:0009214)8.05102954
5cAMP catabolic process (GO:0006198)7.89627066
6meiotic chromosome segregation (GO:0045132)5.69254827
7establishment of protein localization to Golgi (GO:0072600)5.68059726
8mRNA cleavage (GO:0006379)5.46870190
9protein targeting to Golgi (GO:0000042)5.43957940
10regulation of cAMP-mediated signaling (GO:0043949)5.37116745
11regulation of mRNA 3-end processing (GO:0031440)5.22119904
12cGMP metabolic process (GO:0046068)5.20872618
13retrograde transport, vesicle recycling within Golgi (GO:0000301)4.85814474
14positive regulation of mRNA 3-end processing (GO:0031442)4.66115369
15protein localization to Golgi apparatus (GO:0034067)4.34617636
16acrosome assembly (GO:0001675)4.32606202
17calcium ion import (GO:0070509)4.30907671
18sphingosine metabolic process (GO:0006670)4.28574180
19fucose catabolic process (GO:0019317)4.14494730
20L-fucose metabolic process (GO:0042354)4.14494730
21L-fucose catabolic process (GO:0042355)4.14494730
22kinetochore organization (GO:0051383)3.94539776
23negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.73517552
24diol metabolic process (GO:0034311)3.66474859
25regulation of type B pancreatic cell apoptotic process (GO:2000674)3.61937872
26C4-dicarboxylate transport (GO:0015740)3.57641629
27histone mRNA metabolic process (GO:0008334)3.57310821
28protein-chromophore linkage (GO:0018298)3.54788207
29glycine transport (GO:0015816)3.41942399
30spliceosomal snRNP assembly (GO:0000387)3.40969469
31base-excision repair, AP site formation (GO:0006285)3.37953530
32DNA deamination (GO:0045006)3.36395711
33negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.35317939
34protein localization to chromosome, centromeric region (GO:0071459)3.35084212
35alanine transport (GO:0032328)3.34150760
36protein polyglutamylation (GO:0018095)3.33021413
37RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.31440753
38positive regulation of mRNA processing (GO:0050685)3.28660253
39cellular response to ethanol (GO:0071361)3.25462288
40sphingoid metabolic process (GO:0046519)3.22238734
41replication fork processing (GO:0031297)3.17834406
42somite rostral/caudal axis specification (GO:0032525)3.15321479
43regulation of cilium movement (GO:0003352)3.13371269
44cysteine metabolic process (GO:0006534)3.13346122
45histone H3-K4 trimethylation (GO:0080182)3.13025512
46negative regulation of mRNA processing (GO:0050686)3.09562481
47cytidine metabolic process (GO:0046087)3.09372119
48cytidine catabolic process (GO:0006216)3.09372119
49cytidine deamination (GO:0009972)3.09372119
50magnesium ion transport (GO:0015693)3.05611503
51regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.04996263
52membrane depolarization during action potential (GO:0086010)3.02636742
53negative regulation of nitric-oxide synthase activity (GO:0051001)3.01829132
54protein localization to kinetochore (GO:0034501)2.96872105
55positive regulation of mRNA metabolic process (GO:1903313)2.94453842
56regulation of glucokinase activity (GO:0033131)2.89902053
57regulation of hexokinase activity (GO:1903299)2.89902053
58localization within membrane (GO:0051668)2.89141607
59adenosine metabolic process (GO:0046085)2.85524752
60gene silencing by RNA (GO:0031047)2.84793131
61cAMP metabolic process (GO:0046058)2.83788297
62membrane budding (GO:0006900)2.83221419
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.82024380
64positive regulation of protein homodimerization activity (GO:0090073)2.81896870
65proline transport (GO:0015824)2.81409659
66cellular response to sterol (GO:0036315)2.81233858
67cellular response to cholesterol (GO:0071397)2.80888747
68pyrimidine ribonucleoside catabolic process (GO:0046133)2.80809929
69negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78701864
70negative regulation of translation, ncRNA-mediated (GO:0040033)2.78701864
71regulation of translation, ncRNA-mediated (GO:0045974)2.78701864
72negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.78374732
73negative regulation of macrophage differentiation (GO:0045650)2.76438136
74positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.70770191
757-methylguanosine mRNA capping (GO:0006370)2.69825287
76cellular response to ATP (GO:0071318)2.67795265
77regulation of spindle organization (GO:0090224)2.65670369
78mitotic chromosome condensation (GO:0007076)2.64493018
79preassembly of GPI anchor in ER membrane (GO:0016254)2.64207430
80intra-Golgi vesicle-mediated transport (GO:0006891)2.63588788
817-methylguanosine RNA capping (GO:0009452)2.62841863
82RNA capping (GO:0036260)2.62841863
83negative regulation of mRNA metabolic process (GO:1903312)2.59933401
84proteasome assembly (GO:0043248)2.59280219
85microtubule severing (GO:0051013)2.58919726
86leukocyte tethering or rolling (GO:0050901)2.58683870
87postreplication repair (GO:0006301)2.58659325
88myelin assembly (GO:0032288)2.58142541
89folic acid-containing compound biosynthetic process (GO:0009396)2.57846030
90retina development in camera-type eye (GO:0060041)2.57009668
91rRNA catabolic process (GO:0016075)2.55413859
92protein K63-linked deubiquitination (GO:0070536)2.53716547
93cell wall macromolecule catabolic process (GO:0016998)2.52569986
94negative regulation of RNA splicing (GO:0033119)2.50326860
95succinate metabolic process (GO:0006105)2.49559289
96cellular response to lithium ion (GO:0071285)2.48819063
97attachment of spindle microtubules to kinetochore (GO:0008608)2.47873775
98mitotic metaphase plate congression (GO:0007080)2.47120410
99positive regulation of filopodium assembly (GO:0051491)2.46784326
100maturation of 5.8S rRNA (GO:0000460)2.44194836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse5.20179554
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.83394762
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.08363049
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.82356049
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.64092009
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.18277553
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.93261631
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.86892403
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.74817567
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.72684852
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.70821220
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57045735
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52554125
14IRF1_19129219_ChIP-ChIP_H3396_Human2.47808001
15ZNF274_21170338_ChIP-Seq_K562_Hela2.33605505
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28561902
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18087433
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.17160016
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16829374
20E2F7_22180533_ChIP-Seq_HELA_Human2.14079685
21VDR_22108803_ChIP-Seq_LS180_Human2.06540269
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98142259
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97157642
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90432440
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90249497
26VDR_23849224_ChIP-Seq_CD4+_Human1.89045657
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81880806
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80824062
29ELK1_19687146_ChIP-ChIP_HELA_Human1.78640701
30PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.78488798
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.70774307
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68250174
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68084705
34FOXP3_21729870_ChIP-Seq_TREG_Human1.57621241
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57552888
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55410054
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54917149
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53521681
39CIITA_25753668_ChIP-Seq_RAJI_Human1.53266706
40FUS_26573619_Chip-Seq_HEK293_Human1.52436913
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48349079
42GBX2_23144817_ChIP-Seq_PC3_Human1.42250211
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40750882
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.40429897
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39439642
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39325103
47AR_21572438_ChIP-Seq_LNCaP_Human1.35447503
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35383466
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32791937
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30847815
51LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27461128
52ER_23166858_ChIP-Seq_MCF-7_Human1.22003492
53GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18456398
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18355960
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14432756
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14181741
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13447407
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12962169
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.12594641
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10790511
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09902166
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09801242
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09131481
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08803103
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.06718877
66TP53_22573176_ChIP-Seq_HFKS_Human1.06267549
67GABP_19822575_ChIP-Seq_HepG2_Human1.05922136
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.03764756
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03079848
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03032611
71IGF1R_20145208_ChIP-Seq_DFB_Human1.02390917
72MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00692680
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00630967
74DCP1A_22483619_ChIP-Seq_HELA_Human0.99584099
75KDM5A_27292631_Chip-Seq_BREAST_Human0.99566205
76ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98548893
77PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97738653
78P300_19829295_ChIP-Seq_ESCs_Human0.97679257
79FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95493027
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.92231180
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89493101
82E2F1_18555785_Chip-Seq_ESCs_Mouse0.88674430
83SRF_21415370_ChIP-Seq_HL-1_Mouse0.88157459
84TFEB_21752829_ChIP-Seq_HELA_Human0.87859533
85TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.87799034
86GATA3_26560356_Chip-Seq_TH2_Human0.86532412
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85723855
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85154530
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84638525
90NMYC_18555785_Chip-Seq_ESCs_Mouse0.84024958
91HOXB7_26014856_ChIP-Seq_BT474_Human0.82566991
92EWS_26573619_Chip-Seq_HEK293_Human0.81484254
93GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81316215
94P53_22387025_ChIP-Seq_ESCs_Mouse0.78565634
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78417861
96GATA3_26560356_Chip-Seq_TH1_Human0.77656785
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77351753
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.76870359
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.76814266
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75577060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.72153326
2MP0003950_abnormal_plasma_membrane3.64325768
3MP0010094_abnormal_chromosome_stability3.34453254
4MP0006292_abnormal_olfactory_placode3.33589020
5MP0003693_abnormal_embryo_hatching3.23388512
6MP0008058_abnormal_DNA_repair3.19225197
7MP0002396_abnormal_hematopoietic_system3.01557376
8MP0002138_abnormal_hepatobiliary_system2.97803065
9MP0000569_abnormal_digit_pigmentation2.94692900
10MP0003111_abnormal_nucleus_morphology2.86359587
11MP0002638_abnormal_pupillary_reflex2.47165053
12MP0008775_abnormal_heart_ventricle2.43869269
13MP0003786_premature_aging2.36860524
14MP0008877_abnormal_DNA_methylation2.20315323
15MP0003077_abnormal_cell_cycle2.07275026
16MP0006036_abnormal_mitochondrial_physio1.98202157
17MP0003718_maternal_effect1.95736715
18MP0005551_abnormal_eye_electrophysiolog1.92832715
19MP0002102_abnormal_ear_morphology1.87644518
20MP0003195_calcinosis1.79128785
21MP0001853_heart_inflammation1.77295968
22MP0006035_abnormal_mitochondrial_morpho1.69142996
23MP0000685_abnormal_immune_system1.66848697
24MP0008007_abnormal_cellular_replicative1.46946510
25MP0004957_abnormal_blastocyst_morpholog1.44103762
26MP0004484_altered_response_of1.41115017
27MP0003186_abnormal_redox_activity1.39168829
28MP0002234_abnormal_pharynx_morphology1.38322682
29MP0002837_dystrophic_cardiac_calcinosis1.33239930
30MP0005171_absent_coat_pigmentation1.29267274
31MP0001800_abnormal_humoral_immune1.23541366
32MP0002184_abnormal_innervation1.22074101
33MP0004215_abnormal_myocardial_fiber1.21681629
34MP0002938_white_spotting1.19247553
35MP0004145_abnormal_muscle_electrophysio1.13433609
36MP0001835_abnormal_antigen_presentation1.13297521
37MP0001697_abnormal_embryo_size1.09404113
38MP0005332_abnormal_amino_acid1.07574464
39MP0008770_decreased_survivor_rate1.05407758
40MP0005584_abnormal_enzyme/coenzyme_acti1.05341921
41MP0003943_abnormal_hepatobiliary_system1.05300222
42MP0000313_abnormal_cell_death1.04423343
43MP0000703_abnormal_thymus_morphology1.00567240
44MP0000689_abnormal_spleen_morphology1.00481687
45MP0001661_extended_life_span0.97903073
46MP0002148_abnormal_hypersensitivity_rea0.97655535
47MP0002398_abnormal_bone_marrow0.97333799
48MP0002452_abnormal_antigen_presenting0.95782495
49MP0002722_abnormal_immune_system0.93159673
50MP0000383_abnormal_hair_follicle0.92809908
51MP0005379_endocrine/exocrine_gland_phen0.91623806
52MP0002876_abnormal_thyroid_physiology0.89720447
53MP0002420_abnormal_adaptive_immunity0.89116155
54MP0002723_abnormal_immune_serum0.88463262
55MP0008260_abnormal_autophagy0.87402109
56MP0002006_tumorigenesis0.87328664
57MP0009785_altered_susceptibility_to0.85236469
58MP0001819_abnormal_immune_cell0.85175649
59MP0001293_anophthalmia0.85094171
60MP0009333_abnormal_splenocyte_physiolog0.84132397
61MP0002693_abnormal_pancreas_physiology0.83390591
62MP0002751_abnormal_autonomic_nervous0.83316177
63MP0003984_embryonic_growth_retardation0.83154341
64MP0008873_increased_physiological_sensi0.82801650
65MP0002557_abnormal_social/conspecific_i0.82301449
66MP0000350_abnormal_cell_proliferation0.81637966
67MP0002088_abnormal_embryonic_growth/wei0.78823986
68MP0005408_hypopigmentation0.77512214
69MP0008932_abnormal_embryonic_tissue0.76947646
70MP0009764_decreased_sensitivity_to0.76903446
71MP0005387_immune_system_phenotype0.76161260
72MP0001790_abnormal_immune_system0.76161260
73MP0004381_abnormal_hair_follicle0.76114291
74MP0005084_abnormal_gallbladder_morpholo0.75023551
75MP0005380_embryogenesis_phenotype0.74908856
76MP0001672_abnormal_embryogenesis/_devel0.74908856
77MP0005395_other_phenotype0.73817460
78MP0004019_abnormal_vitamin_homeostasis0.72869938
79MP0003868_abnormal_feces_composition0.72855407
80MP0000372_irregular_coat_pigmentation0.71656768
81MP0000358_abnormal_cell_content/0.71054765
82MP0000716_abnormal_immune_system0.70855691
83MP0005253_abnormal_eye_physiology0.70289670
84MP0008789_abnormal_olfactory_epithelium0.69493977
85MP0002429_abnormal_blood_cell0.69055274
86MP0001286_abnormal_eye_development0.68415774
87MP0005319_abnormal_enzyme/_coenzyme0.68411950
88MP0005083_abnormal_biliary_tract0.66816010
89MP0001501_abnormal_sleep_pattern0.66721011
90MP0005671_abnormal_response_to0.65899836
91MP0001944_abnormal_pancreas_morphology0.65365198
92MP0002092_abnormal_eye_morphology0.65246164
93MP0001145_abnormal_male_reproductive0.65216703
94MP0005000_abnormal_immune_tolerance0.64806489
95MP0004808_abnormal_hematopoietic_stem0.64667711
96MP0010678_abnormal_skin_adnexa0.64485051
97MP0006072_abnormal_retinal_apoptosis0.63995675
98MP0001784_abnormal_fluid_regulation0.63879828
99MP0002019_abnormal_tumor_incidence0.63465859
100MP0004142_abnormal_muscle_tone0.62929033

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)9.67885929
2Central scotoma (HP:0000603)9.18851965
3Abnormal rod and cone electroretinograms (HP:0008323)8.17201083
4Abnormality of the fovea (HP:0000493)8.12965560
5Albinism (HP:0001022)7.83984791
6Abnormality of macular pigmentation (HP:0008002)7.75880396
7Aplasia/Hypoplasia of the macula (HP:0008059)6.59811278
8Aplasia/Hypoplasia affecting the retina (HP:0008061)6.08574935
9Renal cortical cysts (HP:0000803)5.90085207
10Scotoma (HP:0000575)5.32062586
11Generalized aminoaciduria (HP:0002909)4.54105047
12Abnormality of the renal cortex (HP:0011035)3.81577189
13Acute lymphatic leukemia (HP:0006721)3.58264642
14Proximal tubulopathy (HP:0000114)3.44212358
15Generalized hypopigmentation (HP:0007513)3.36271390
16Hypoglycemic coma (HP:0001325)3.20343574
17Nausea (HP:0002018)2.70461105
18Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.65369724
19Tubulointerstitial nephritis (HP:0001970)2.64708218
20Progressive hearing impairment (HP:0001730)2.60956699
21Anomalous pulmonary venous return (HP:0010772)2.54884485
22Degeneration of anterior horn cells (HP:0002398)2.49956663
23Abnormality of the anterior horn cell (HP:0006802)2.49956663
24Molar tooth sign on MRI (HP:0002419)2.46030556
25Abnormality of midbrain morphology (HP:0002418)2.46030556
26Abnormality of the pulmonary veins (HP:0011718)2.27551277
27Aplasia/Hypoplasia of the tibia (HP:0005772)2.27526832
28Rib fusion (HP:0000902)2.26322982
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23172468
30Hepatic necrosis (HP:0002605)2.20906808
31Median cleft lip (HP:0000161)2.18776170
32Neonatal death (HP:0003811)2.11359267
33Progressive inability to walk (HP:0002505)2.10009368
34Congenital stationary night blindness (HP:0007642)10.5540580
35Aplasia/Hypoplasia of the fovea (HP:0008060)10.1444982
36Hypoplasia of the fovea (HP:0007750)10.1444982
37Glycosuria (HP:0003076)1.98435767
38Abnormality of urine glucose concentration (HP:0011016)1.98435767
39Tubular atrophy (HP:0000092)1.98241122
40Short tibia (HP:0005736)1.96885170
41Hypochromic microcytic anemia (HP:0004840)1.96094055
42Constricted visual fields (HP:0001133)1.94711868
43Colon cancer (HP:0003003)1.89870519
44Overlapping toe (HP:0001845)1.84049664
45Abnormality of lateral ventricle (HP:0030047)1.79347770
46Chronic mucocutaneous candidiasis (HP:0002728)1.78021509
47Recurrent cutaneous fungal infections (HP:0011370)1.78021509
48Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73653452
49White forelock (HP:0002211)1.73345411
50Astigmatism (HP:0000483)1.69365772
51Intellectual disability, progressive (HP:0006887)1.69220567
52Abnormality of fatty-acid metabolism (HP:0004359)1.68248172
53Stomach cancer (HP:0012126)1.66799125
54Clubbing of toes (HP:0100760)1.63703738
55Thin upper lip vermilion (HP:0000219)1.62194130
56Severe muscular hypotonia (HP:0006829)1.60915181
57Neoplasm of the oral cavity (HP:0100649)1.58652575
58Inability to walk (HP:0002540)1.57934887
59Attenuation of retinal blood vessels (HP:0007843)1.57519341
60Type II lissencephaly (HP:0007260)1.55508985
61Large eyes (HP:0001090)1.55039781
62Decreased central vision (HP:0007663)1.52081698
63Nephronophthisis (HP:0000090)1.51813608
64Stomatitis (HP:0010280)1.50523243
65Autoimmune hemolytic anemia (HP:0001890)1.50407365
66Abnormality of oral frenula (HP:0000190)1.48849124
67Spinal muscular atrophy (HP:0007269)1.47319321
68Acute necrotizing encephalopathy (HP:0006965)1.46823082
69Patchy hypopigmentation of hair (HP:0011365)1.46615257
70Tubulointerstitial abnormality (HP:0001969)1.46578074
71Increased serum pyruvate (HP:0003542)1.44805736
72Chromsome breakage (HP:0040012)1.44603245
73Small hand (HP:0200055)1.44583044
74Tetraplegia (HP:0002445)1.40977565
75Small intestinal stenosis (HP:0012848)1.40929042
76Duodenal stenosis (HP:0100867)1.40929042
77Acute myeloid leukemia (HP:0004808)1.37977049
78Pachygyria (HP:0001302)1.35632460
79Aplasia/Hypoplasia of the uvula (HP:0010293)1.33984497
80Abnormality of the renal medulla (HP:0100957)1.33730687
81Azoospermia (HP:0000027)1.33557154
82Ulnar claw (HP:0001178)1.31364281
83Oculomotor apraxia (HP:0000657)1.26507639
84IgM deficiency (HP:0002850)1.25695311
85Abnormal lung lobation (HP:0002101)1.25055347
86Hydroxyprolinuria (HP:0003080)1.24701300
87Abnormality of proline metabolism (HP:0010907)1.24701300
88Abnormality of the duodenum (HP:0002246)1.24258796
89Chronic diarrhea (HP:0002028)1.23977118
90Limb dystonia (HP:0002451)1.23701409
91Acute encephalopathy (HP:0006846)1.23046913
92Decreased electroretinogram (ERG) amplitude (HP:0000654)1.22193421
93IgA deficiency (HP:0002720)1.21713794
94Abnormal mitochondria in muscle tissue (HP:0008316)1.21243327
95Lissencephaly (HP:0001339)1.20824465
96Congenital, generalized hypertrichosis (HP:0004540)1.20292921
97Hypercholesterolemia (HP:0003124)1.19973621
98Entropion (HP:0000621)1.19747715
99Polydipsia (HP:0001959)1.19720419
100Abnormal drinking behavior (HP:0030082)1.19720419

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD45.98172174
2FRK3.67888584
3BLK3.27969036
4BRSK23.09894097
5CCNB12.89710672
6MAPKAPK32.70108382
7BUB12.66804341
8EIF2AK32.56907601
9GRK12.16055625
10CSNK1G32.12288830
11CSNK1G12.01691926
12CDK121.99192203
13TRPM71.94925526
14CSNK1A1L1.94803966
15TTK1.89190677
16ADRBK21.88103850
17PTK2B1.83896180
18CAMKK21.66277801
19PLK41.61196219
20ZAK1.59889238
21MET1.56290661
22DAPK11.51277832
23CSNK1G21.49879105
24ATR1.47308710
25BRSK11.44930607
26EIF2AK11.44496428
27TAOK31.32282723
28MAPK71.25762383
29CSF1R1.24921657
30PLK31.21630691
31NUAK11.21401810
32STK31.18788164
33MAPKAPK51.18344928
34STK101.12349072
35CDC42BPA1.10546194
36PAK31.09945930
37FGR1.09275868
38NEK11.09199394
39CDC71.06905388
40ACVR1B1.05980357
41MST41.03424564
42TXK1.02562256
43CLK10.97838783
44RPS6KB10.97405013
45FES0.96638398
46STK40.93255725
47WNK30.93148839
48PBK0.92681484
49PLK10.90815832
50MARK30.90514775
51VRK20.87552034
52TSSK60.87125270
53ZAP700.86919016
54VRK10.86030215
55STK160.82247781
56CHEK20.82200423
57DAPK20.80276134
58PRKD20.74235711
59EIF2AK20.72779971
60NEK20.71816186
61MAP3K50.71194655
62TEC0.61026448
63TAF10.59716155
64AURKB0.59232859
65NME10.59184476
66BMX0.59091349
67SYK0.56612299
68CSNK1A10.55678136
69IKBKB0.55395155
70WNK40.53563217
71WEE10.51440854
72ATM0.49399237
73PRKG10.48116104
74NEK90.47345448
75CDK40.45801562
76CSNK1D0.45361372
77PRKCQ0.43735817
78MKNK20.43701743
79CSNK1E0.42912933
80CHUK0.42504097
81MAP3K140.41043441
82BRAF0.40518573
83IRAK30.39858097
84OXSR10.39504108
85TNIK0.38347543
86MAP3K80.38336993
87SRPK10.37858978
88ADRBK10.37033113
89ROCK20.36803493
90PRKACA0.35506123
91TIE10.35018712
92ROCK10.34286001
93PRKCB0.33802856
94CHEK10.33743224
95CAMK2D0.33680314
96STK38L0.33637050
97TRIM280.32334712
98RAF10.32241005
99IRAK40.32225702
100BTK0.32054413

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.09044542
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.38547918
3Proteasome_Homo sapiens_hsa030503.26672009
4Homologous recombination_Homo sapiens_hsa034402.84706935
5Spliceosome_Homo sapiens_hsa030402.81460296
6Selenocompound metabolism_Homo sapiens_hsa004502.31140400
7Basal transcription factors_Homo sapiens_hsa030222.06732917
8One carbon pool by folate_Homo sapiens_hsa006702.03117845
9Renin secretion_Homo sapiens_hsa049241.97866432
10Non-homologous end-joining_Homo sapiens_hsa034501.95646678
11beta-Alanine metabolism_Homo sapiens_hsa004101.93973696
12RNA transport_Homo sapiens_hsa030131.93223089
13Folate biosynthesis_Homo sapiens_hsa007901.86243319
14Base excision repair_Homo sapiens_hsa034101.77317887
15Fanconi anemia pathway_Homo sapiens_hsa034601.76935195
16Protein export_Homo sapiens_hsa030601.72439246
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69771409
18Purine metabolism_Homo sapiens_hsa002301.59708598
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59235914
20mRNA surveillance pathway_Homo sapiens_hsa030151.52648873
21Primary immunodeficiency_Homo sapiens_hsa053401.50171464
22GABAergic synapse_Homo sapiens_hsa047271.46581633
23Nucleotide excision repair_Homo sapiens_hsa034201.46542690
24RNA degradation_Homo sapiens_hsa030181.44920695
25Morphine addiction_Homo sapiens_hsa050321.43342209
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.42608555
27Lysine degradation_Homo sapiens_hsa003101.39710875
28Type I diabetes mellitus_Homo sapiens_hsa049401.39280440
29Mismatch repair_Homo sapiens_hsa034301.38951687
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37898166
31Cardiac muscle contraction_Homo sapiens_hsa042601.35815729
32Regulation of autophagy_Homo sapiens_hsa041401.34327913
33Serotonergic synapse_Homo sapiens_hsa047261.34028159
34Cell cycle_Homo sapiens_hsa041101.25306831
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21766872
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.20935637
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17754310
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.17630774
39Insulin secretion_Homo sapiens_hsa049111.16176643
40Butanoate metabolism_Homo sapiens_hsa006501.15818725
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11241251
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07643218
43DNA replication_Homo sapiens_hsa030301.04919292
44Sulfur metabolism_Homo sapiens_hsa009201.04886586
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02806235
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01337298
47Fatty acid elongation_Homo sapiens_hsa000621.01134540
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98235065
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98033643
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96574520
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93848289
52p53 signaling pathway_Homo sapiens_hsa041150.92049174
53Calcium signaling pathway_Homo sapiens_hsa040200.91834465
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91723721
55Pyrimidine metabolism_Homo sapiens_hsa002400.91297537
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89197509
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89101495
58Oxytocin signaling pathway_Homo sapiens_hsa049210.87484808
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87012502
60Tryptophan metabolism_Homo sapiens_hsa003800.86524520
61Sphingolipid metabolism_Homo sapiens_hsa006000.85876827
62Ether lipid metabolism_Homo sapiens_hsa005650.84346195
63Fatty acid biosynthesis_Homo sapiens_hsa000610.82044933
64Cholinergic synapse_Homo sapiens_hsa047250.80286147
65Nitrogen metabolism_Homo sapiens_hsa009100.74900993
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72420119
67Alzheimers disease_Homo sapiens_hsa050100.71399447
68Phototransduction_Homo sapiens_hsa047440.67378220
69RNA polymerase_Homo sapiens_hsa030200.67161058
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63235295
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.63060690
72Dilated cardiomyopathy_Homo sapiens_hsa054140.62906060
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.61223756
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59539487
75Propanoate metabolism_Homo sapiens_hsa006400.58289959
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57226564
77T cell receptor signaling pathway_Homo sapiens_hsa046600.55711540
78Autoimmune thyroid disease_Homo sapiens_hsa053200.52550404
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.51075529
80Herpes simplex infection_Homo sapiens_hsa051680.49553115
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48614628
82Antigen processing and presentation_Homo sapiens_hsa046120.47028112
83GnRH signaling pathway_Homo sapiens_hsa049120.46034241
84Graft-versus-host disease_Homo sapiens_hsa053320.45750578
85Hematopoietic cell lineage_Homo sapiens_hsa046400.45693947
86Fatty acid metabolism_Homo sapiens_hsa012120.45088135
87N-Glycan biosynthesis_Homo sapiens_hsa005100.44415466
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44229033
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43425566
90Allograft rejection_Homo sapiens_hsa053300.42882026
91Histidine metabolism_Homo sapiens_hsa003400.40933793
92Asthma_Homo sapiens_hsa053100.40445059
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39595105
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39156880
95Linoleic acid metabolism_Homo sapiens_hsa005910.36337319
96Oocyte meiosis_Homo sapiens_hsa041140.35278893
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34824318
98Shigellosis_Homo sapiens_hsa051310.33217105
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.32482860
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.32007579

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