ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	rRNA modification (GO:0000154)	5.67582099
2	rRNA methylation (GO:0031167)	5.49121142
3	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.27972850
4	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.27972850
5	DNA deamination (GO:0045006)	4.82582864
6	proteasome assembly (GO:0043248)	4.70282962
7	folic acid-containing compound biosynthetic process (GO:0009396)	4.49436800
8	purine nucleotide salvage (GO:0032261)	4.18681883
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.78182480
10	ribosome assembly (GO:0042255)	3.77556620
11	IMP biosynthetic process (GO:0006188)	3.76361476
12	adenosine metabolic process (GO:0046085)	3.74669274
13	DNA double-strand break processing (GO:0000729)	3.73159350
14	pseudouridine synthesis (GO:0001522)	3.58706493
15	protein-cofactor linkage (GO:0018065)	3.56059393
16	CENP-A containing nucleosome assembly (GO:0034080)	3.55241208
17	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.49757525
18	pteridine-containing compound biosynthetic process (GO:0042559)	3.48955472
19	regulation of cellular amino acid metabolic process (GO:0006521)	3.46530228
20	protein complex biogenesis (GO:0070271)	3.42058922
21	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.40666658
22	mitochondrial RNA metabolic process (GO:0000959)	3.39541290
23	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.38934103
24	histone exchange (GO:0043486)	3.38657431
25	ribosome biogenesis (GO:0042254)	3.37353205
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.35063042
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.35063042
28	NADH dehydrogenase complex assembly (GO:0010257)	3.35063042
29	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.34311360
30	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.33214743
31	GTP biosynthetic process (GO:0006183)	3.32831059
32	chromatin remodeling at centromere (GO:0031055)	3.32454587
33	tRNA modification (GO:0006400)	3.31953536
34	tRNA processing (GO:0008033)	3.27110508
35	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.25648378
36	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.24929455
37	DNA ligation (GO:0006266)	3.19362605
38	IMP metabolic process (GO:0046040)	3.19009376
39	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.18639514
40	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.18639514
41	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.18639514
42	platelet dense granule organization (GO:0060155)	3.18101146
43	mitochondrial respiratory chain complex assembly (GO:0033108)	3.17130795
44	purine nucleobase biosynthetic process (GO:0009113)	3.16250189
45	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.15698370
46	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.15698370
47	L-serine metabolic process (GO:0006563)	3.15320067
48	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.13809679
49	positive regulation of prostaglandin secretion (GO:0032308)	3.13107010
50	positive regulation of mitochondrial fission (GO:0090141)	3.10966682
51	protein polyglutamylation (GO:0018095)	3.09787973
52	positive regulation of endothelial cell differentiation (GO:0045603)	3.09631417
53	purine-containing compound salvage (GO:0043101)	3.07809582
54	amino acid salvage (GO:0043102)	3.07663396
55	L-methionine salvage (GO:0071267)	3.07663396
56	L-methionine biosynthetic process (GO:0071265)	3.07663396
57	homocysteine metabolic process (GO:0050667)	3.05883250
58	guanosine-containing compound biosynthetic process (GO:1901070)	3.05835976
59	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.05071009
60	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.05071009
61	DNA catabolic process, exonucleolytic (GO:0000738)	3.03403786
62	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.02583678
63	negative regulation of ligase activity (GO:0051352)	3.02583678
64	respiratory chain complex IV assembly (GO:0008535)	3.02500536
65	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.01728813
66	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.99238894
67	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.99089010
68	replication fork processing (GO:0031297)	2.93325773
69	cytidine deamination (GO:0009972)	2.92378189
70	cytidine metabolic process (GO:0046087)	2.92378189
71	cytidine catabolic process (GO:0006216)	2.92378189
72	response to pheromone (GO:0019236)	2.91934660
73	chaperone-mediated protein transport (GO:0072321)	2.90977332
74	establishment of integrated proviral latency (GO:0075713)	2.90733121
75	sperm motility (GO:0030317)	2.88702302
76	fusion of sperm to egg plasma membrane (GO:0007342)	2.87569108
77	nucleobase biosynthetic process (GO:0046112)	2.86328376
78	sperm-egg recognition (GO:0035036)	2.86047737
79	UTP metabolic process (GO:0046051)	2.84210693
80	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.83924988
81	negative regulation of B cell apoptotic process (GO:0002903)	2.83530681
82	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.82752777
83	cell wall macromolecule catabolic process (GO:0016998)	2.82028206
84	rRNA processing (GO:0006364)	2.77177680
85	positive regulation of ligase activity (GO:0051351)	2.76295665
86	sulfur amino acid catabolic process (GO:0000098)	2.75867433
87	serine family amino acid catabolic process (GO:0009071)	2.75475881
88	serine family amino acid biosynthetic process (GO:0009070)	2.73215162
89	DNA damage response, detection of DNA damage (GO:0042769)	2.72998281
90	tRNA metabolic process (GO:0006399)	2.72604588
91	CTP metabolic process (GO:0046036)	2.71837471
92	CTP biosynthetic process (GO:0006241)	2.71837471
93	cysteine metabolic process (GO:0006534)	2.71379770
94	UTP biosynthetic process (GO:0006228)	2.70631655
95	GMP metabolic process (GO:0046037)	2.68922144
96	sulfur amino acid biosynthetic process (GO:0000097)	2.68846346
97	rRNA metabolic process (GO:0016072)	2.68749074
98	termination of RNA polymerase III transcription (GO:0006386)	2.67700600
99	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.67700600
100	mannosylation (GO:0097502)	2.66356315

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	7.98934171
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.77166936
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.13399795
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.58649373
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.50221362
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.44210203
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.09606771
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.89442471
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.85901248
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.69888342
11	VDR_22108803_ChIP-Seq_LS180_Human	2.68685803
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.64563332
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.61091187
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.47790820
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.29007492
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.26450362
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.21817063
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.13647710
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.09019439
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.90602919
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.85753429
22	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.85582561
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.79740800
24	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.76447155
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.72047559
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69379146
27	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.69364401
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.68251060
29	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.67006854
30	GABP_19822575_ChIP-Seq_HepG2_Human	1.66785889
31	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.64340660
32	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.62205523
33	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.58762976
34	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.55510082
35	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.54599902
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.46002541
37	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.45436736
38	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.42569939
39	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.42531024
40	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.35516543
41	EWS_26573619_Chip-Seq_HEK293_Human	1.33057123
42	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32215040
43	FUS_26573619_Chip-Seq_HEK293_Human	1.32177627
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.31310923
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28534806
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.28212989
47	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.25985086
48	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.25325940
49	DCP1A_22483619_ChIP-Seq_HELA_Human	1.22927774
50	XRN2_22483619_ChIP-Seq_HELA_Human	1.22104951
51	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.20362607
52	TTF2_22483619_ChIP-Seq_HELA_Human	1.20170446
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.19008037
54	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.18814742
55	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.18361885
56	TAF15_26573619_Chip-Seq_HEK293_Human	1.17472367
57	P300_19829295_ChIP-Seq_ESCs_Human	1.15394046
58	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.15130059
59	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.08577863
60	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.07733348
61	NCOR_22424771_ChIP-Seq_293T_Human	1.07045322
62	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.06126540
63	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.05543666
64	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.04963182
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04364278
66	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04364278
67	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03831718
68	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.01725204
69	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.99792398
70	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.99582252
71	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98721689
72	IRF1_19129219_ChIP-ChIP_H3396_Human	0.97949316
73	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.97692412
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97636894
75	AR_20517297_ChIP-Seq_VCAP_Human	0.97489269
76	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94825041
77	CBP_20019798_ChIP-Seq_JUKART_Human	0.94825041
78	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.93601692
79	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.93488265
80	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.93170391
81	ERG_20517297_ChIP-Seq_VCAP_Human	0.91211630
82	HOXB7_26014856_ChIP-Seq_BT474_Human	0.91071535
83	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90895741
84	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90895741
85	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90079586
86	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.89847195
87	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.89832191
88	CIITA_25753668_ChIP-Seq_RAJI_Human	0.89251219
89	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.88325035
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.88219048
91	GATA3_26560356_Chip-Seq_TH2_Human	0.87982306
92	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.87830353
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.87551642
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87460848
95	ERA_21632823_ChIP-Seq_H3396_Human	0.87160335
96	ER_23166858_ChIP-Seq_MCF-7_Human	0.86731287
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.85266950
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.83887307
99	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.83464385
100	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.82300958

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008995_early_reproductive_senescence	3.25732156
2	MP0002138_abnormal_hepatobiliary_system	3.15989611
3	MP0005410_abnormal_fertilization	2.93850399
4	MP0008058_abnormal_DNA_repair	2.87688021
5	MP0006292_abnormal_olfactory_placode	2.71834894
6	MP0003693_abnormal_embryo_hatching	2.71493566
7	MP0003718_maternal_effect	2.60880437
8	MP0002736_abnormal_nociception_after	2.55609463
9	MP0009697_abnormal_copulation	2.54064417
10	MP0003806_abnormal_nucleotide_metabolis	2.51970329
11	MP0005084_abnormal_gallbladder_morpholo	2.48187429
12	MP0003786_premature_aging	2.45197817
13	MP0002102_abnormal_ear_morphology	2.43577638
14	MP0004147_increased_porphyrin_level	2.38536523
15	MP0010094_abnormal_chromosome_stability	2.34435171
16	MP0000516_abnormal_urinary_system	2.30485777
17	MP0005367_renal/urinary_system_phenotyp	2.30485777
18	MP0005360_urolithiasis	2.26583496
19	MP0004957_abnormal_blastocyst_morpholog	2.21183689
20	MP0008877_abnormal_DNA_methylation	2.08756846
21	MP0005646_abnormal_pituitary_gland	2.02297910
22	MP0001661_extended_life_span	1.97682731
23	MP0003183_abnormal_peptide_metabolism	1.87753459
24	MP0001764_abnormal_homeostasis	1.87681265
25	MP0002139_abnormal_hepatobiliary_system	1.78564852
26	MP0002876_abnormal_thyroid_physiology	1.77955611
27	MP0006072_abnormal_retinal_apoptosis	1.72598040
28	MP0001929_abnormal_gametogenesis	1.69304367
29	MP0002837_dystrophic_cardiac_calcinosis	1.68935361
30	MP0008872_abnormal_physiological_respon	1.68325333
31	MP0003186_abnormal_redox_activity	1.66897955
32	MP0004885_abnormal_endolymph	1.62752992
33	MP0001968_abnormal_touch/_nociception	1.57617810
34	MP0005085_abnormal_gallbladder_physiolo	1.55187663
35	MP0005379_endocrine/exocrine_gland_phen	1.47971820
36	MP0002938_white_spotting	1.47062818
37	MP0003111_abnormal_nucleus_morphology	1.45539242
38	MP0002163_abnormal_gland_morphology	1.45218035
39	MP0003698_abnormal_male_reproductive	1.44510029
40	MP0005670_abnormal_white_adipose	1.39324363
41	MP0005551_abnormal_eye_electrophysiolog	1.37777469
42	MP0000372_irregular_coat_pigmentation	1.36272468
43	MP0005253_abnormal_eye_physiology	1.34170258
44	MP0005645_abnormal_hypothalamus_physiol	1.28059959
45	MP0003077_abnormal_cell_cycle	1.28034113
46	MP0003646_muscle_fatigue	1.23481058
47	MP0002210_abnormal_sex_determination	1.20099989
48	MP0008007_abnormal_cellular_replicative	1.19377606
49	MP0001293_anophthalmia	1.17979935
50	MP0005671_abnormal_response_to	1.17670531
51	MP0002148_abnormal_hypersensitivity_rea	1.16084659
52	MP0001145_abnormal_male_reproductive	1.09451609
53	MP0006276_abnormal_autonomic_nervous	1.08989816
54	MP0004782_abnormal_surfactant_physiolog	1.07931893
55	MP0003195_calcinosis	1.07858912
56	MP0002277_abnormal_respiratory_mucosa	1.05987703
57	MP0003315_abnormal_perineum_morphology	1.05720036
58	MP0000653_abnormal_sex_gland	1.05539284
59	MP0006035_abnormal_mitochondrial_morpho	1.04348506
60	MP0003011_delayed_dark_adaptation	1.03594580
61	MP0000613_abnormal_salivary_gland	1.01591959
62	MP0002234_abnormal_pharynx_morphology	0.97730465
63	MP0006036_abnormal_mitochondrial_physio	0.96830087
64	MP0008875_abnormal_xenobiotic_pharmacok	0.96679817
65	MP0005167_abnormal_blood-brain_barrier	0.94520395
66	MP0000647_abnormal_sebaceous_gland	0.93679274
67	MP0003724_increased_susceptibility_to	0.92747313
68	MP0005365_abnormal_bile_salt	0.90746093
69	MP0005332_abnormal_amino_acid	0.90603932
70	MP0001963_abnormal_hearing_physiology	0.90184015
71	MP0002095_abnormal_skin_pigmentation	0.90067660
72	MP0008932_abnormal_embryonic_tissue	0.88806755
73	MP0002735_abnormal_chemical_nociception	0.88464801
74	MP0003252_abnormal_bile_duct	0.87421962
75	MP0000465_gastrointestinal_hemorrhage	0.87141686
76	MP0005636_abnormal_mineral_homeostasis	0.87101265
77	MP0001919_abnormal_reproductive_system	0.85969990
78	MP0008789_abnormal_olfactory_epithelium	0.85815757
79	MP0005647_abnormal_sex_gland	0.85183514
80	MP0000049_abnormal_middle_ear	0.83348745
81	MP0005075_abnormal_melanosome_morpholog	0.82571332
82	MP0009764_decreased_sensitivity_to	0.80490792
83	MP0005187_abnormal_penis_morphology	0.79154783
84	MP0000631_abnormal_neuroendocrine_gland	0.77884538
85	MP0001984_abnormal_olfaction	0.77357460
86	MP0002161_abnormal_fertility/fecundity	0.73848467
87	MP0003878_abnormal_ear_physiology	0.73497260
88	MP0005377_hearing/vestibular/ear_phenot	0.73497260
89	MP0002282_abnormal_trachea_morphology	0.73320811
90	MP0001346_abnormal_lacrimal_gland	0.71794866
91	MP0005389_reproductive_system_phenotype	0.71321675
92	MP0001119_abnormal_female_reproductive	0.70347116
93	MP0002160_abnormal_reproductive_system	0.70309013
94	MP0000013_abnormal_adipose_tissue	0.68763839
95	MP0001502_abnormal_circadian_rhythm	0.66709308
96	MP0008775_abnormal_heart_ventricle	0.65643860
97	MP0002396_abnormal_hematopoietic_system	0.65545747
98	MP0005083_abnormal_biliary_tract	0.63875784
99	MP0000026_abnormal_inner_ear	0.63864470
100	MP0005319_abnormal_enzyme/_coenzyme	0.63795214

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	4.67587890
2	Hyperalaninemia (HP:0003348)	4.67587890
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.67587890
4	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.01890858
5	Constricted visual fields (HP:0001133)	3.94605232
6	Attenuation of retinal blood vessels (HP:0007843)	3.57792947
7	Abnormality of serum amino acid levels (HP:0003112)	3.43777654
8	Acute encephalopathy (HP:0006846)	3.08891432
9	Abolished electroretinogram (ERG) (HP:0000550)	3.08002044
10	Increased CSF lactate (HP:0002490)	3.03347535
11	Mitochondrial inheritance (HP:0001427)	3.00969348
12	Hepatocellular necrosis (HP:0001404)	2.99217086
13	Acute necrotizing encephalopathy (HP:0006965)	2.99061787
14	Hyperglycinemia (HP:0002154)	2.96211849
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.95194848
16	Chronic hepatic failure (HP:0100626)	2.89567962
17	Increased serum lactate (HP:0002151)	2.87776664
18	Abnormal respiratory epithelium morphology (HP:0012253)	2.72504552
19	Abnormal respiratory motile cilium morphology (HP:0005938)	2.72504552
20	3-Methylglutaconic aciduria (HP:0003535)	2.71106264
21	Generalized aminoaciduria (HP:0002909)	2.70636795
22	Methylmalonic acidemia (HP:0002912)	2.70297108
23	Retinal dysplasia (HP:0007973)	2.69796998
24	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.69463437
25	Hepatic necrosis (HP:0002605)	2.61912005
26	Lipid accumulation in hepatocytes (HP:0006561)	2.56088667
27	Increased hepatocellular lipid droplets (HP:0006565)	2.50442198
28	Lactic acidosis (HP:0003128)	2.49367711
29	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.47652368
30	Absent/shortened dynein arms (HP:0200106)	2.47652368
31	Decreased central vision (HP:0007663)	2.41513183
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.40976752
33	Reduced antithrombin III activity (HP:0001976)	2.40274557
34	Degeneration of anterior horn cells (HP:0002398)	2.39359313
35	Abnormality of the anterior horn cell (HP:0006802)	2.39359313
36	Cone-rod dystrophy (HP:0000548)	2.36403748
37	Pendular nystagmus (HP:0012043)	2.35309348
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.33717167
39	Methylmalonic aciduria (HP:0012120)	2.32384057
40	Cerebral edema (HP:0002181)	2.31905000
41	Aplastic anemia (HP:0001915)	2.31402391
42	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.29221818
43	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.26366844
44	Increased intramyocellular lipid droplets (HP:0012240)	2.24279711
45	Abnormality of the labia minora (HP:0012880)	2.22144490
46	Congenital sensorineural hearing impairment (HP:0008527)	2.22052912
47	Type I transferrin isoform profile (HP:0003642)	2.21803345
48	Abnormality of midbrain morphology (HP:0002418)	2.19897516
49	Molar tooth sign on MRI (HP:0002419)	2.19897516
50	Progressive macrocephaly (HP:0004481)	2.19659298
51	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.17977318
52	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.17977318
53	Pancreatic cysts (HP:0001737)	2.17661934
54	Renal Fanconi syndrome (HP:0001994)	2.17233073
55	Type II lissencephaly (HP:0007260)	2.17123572
56	Type 2 muscle fiber atrophy (HP:0003554)	2.16036379
57	Glycosuria (HP:0003076)	2.13166380
58	Abnormality of urine glucose concentration (HP:0011016)	2.13166380
59	Optic disc pallor (HP:0000543)	2.09953107
60	Keratoconus (HP:0000563)	2.09049623
61	Increased corneal curvature (HP:0100692)	2.09049623
62	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.05432125
63	Abnormality of homocysteine metabolism (HP:0010919)	2.01281205
64	Homocystinuria (HP:0002156)	2.01281205
65	Abnormality of glycine metabolism (HP:0010895)	2.00978044
66	Abnormality of serine family amino acid metabolism (HP:0010894)	2.00978044
67	Conjunctival telangiectasia (HP:0000524)	1.99684693
68	Tubulointerstitial nephritis (HP:0001970)	1.99406294
69	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.99348171
70	True hermaphroditism (HP:0010459)	1.96337685
71	Increased serum pyruvate (HP:0003542)	1.95294920
72	Abnormality of methionine metabolism (HP:0010901)	1.95262423
73	Abnormal ciliary motility (HP:0012262)	1.93793027
74	Lethargy (HP:0001254)	1.92910893
75	Hyperphosphaturia (HP:0003109)	1.92866488
76	Increased muscle lipid content (HP:0009058)	1.91961844
77	Intestinal atresia (HP:0011100)	1.89539677
78	Chorioretinal atrophy (HP:0000533)	1.88915638
79	White forelock (HP:0002211)	1.88555803
80	IgG deficiency (HP:0004315)	1.88101785
81	Nephronophthisis (HP:0000090)	1.87945752
82	Muscle fiber atrophy (HP:0100295)	1.87374903
83	Cerebral hypomyelination (HP:0006808)	1.84653048
84	Pancytopenia (HP:0001876)	1.83073540
85	Patchy hypopigmentation of hair (HP:0011365)	1.82554480
86	Volvulus (HP:0002580)	1.81575887
87	Delayed CNS myelination (HP:0002188)	1.79774969
88	Chromsome breakage (HP:0040012)	1.79547312
89	Pancreatic fibrosis (HP:0100732)	1.78181655
90	Abnormality of the ileum (HP:0001549)	1.75692732
91	Hyperglycinuria (HP:0003108)	1.74672242
92	Medial flaring of the eyebrow (HP:0010747)	1.74415960
93	Abnormal protein glycosylation (HP:0012346)	1.73983263
94	Abnormal glycosylation (HP:0012345)	1.73983263
95	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.73983263
96	Abnormal protein N-linked glycosylation (HP:0012347)	1.73983263
97	Poor speech (HP:0002465)	1.73699606
98	Colon cancer (HP:0003003)	1.72810569
99	Meckel diverticulum (HP:0002245)	1.72250824
100	Metabolic acidosis (HP:0001942)	1.72139571

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.37457293
2	ZAK	3.07401922
3	TLK1	2.67516041
4	BCKDK	2.66222025
5	MAP4K2	2.59225802
6	TESK2	2.50570018
7	BUB1	2.45386891
8	NUAK1	2.41914360
9	MST4	2.40224155
10	EIF2AK3	2.28901810
11	VRK1	2.27436774
12	TIE1	2.27257028
13	SRPK1	2.21279351
14	CCNB1	2.09942174
15	WNK3	2.06377585
16	PLK4	1.99218245
17	ACVR1B	1.87098080
18	KDR	1.77012859
19	TSSK6	1.74098961
20	PINK1	1.67314877
21	GRK1	1.62334640
22	BMPR1B	1.46273903
23	TRIM28	1.45287288
24	CDC7	1.44343858
25	ADRBK2	1.40625942
26	PLK3	1.40193366
27	BCR	1.34264447
28	INSRR	1.33470651
29	DAPK1	1.30416161
30	TAF1	1.29767027
31	CSNK1G3	1.28257729
32	WNK4	1.26101717
33	STK38L	1.12573165
34	PLK2	1.08048075
35	PBK	1.07987521
36	CSNK1G1	1.04563972
37	RPS6KA4	1.04414466
38	CSNK1A1L	1.00555672
39	TESK1	1.00227186
40	NEK9	0.98830055
41	CSNK1G2	0.98492315
42	DYRK2	0.98084662
43	TNIK	0.97574231
44	STK16	0.96039857
45	ATR	0.94115254
46	CDK8	0.92527165
47	STK39	0.92441751
48	CDK9	0.91268614
49	OXSR1	0.91053782
50	PLK1	0.90116230
51	WEE1	0.88894076
52	NME1	0.86365585
53	EIF2AK1	0.85925608
54	TXK	0.82128445
55	MKNK1	0.81148237
56	FGR	0.80413626
57	RPS6KA5	0.79438983
58	PDK2	0.78534400
59	TEC	0.77221472
60	NEK1	0.75316256
61	MAPK13	0.73355339
62	CDK7	0.71055281
63	FRK	0.71037869
64	CSNK1A1	0.69341682
65	AURKA	0.66505487
66	IKBKB	0.63886396
67	FES	0.60852299
68	EIF2AK2	0.60410879
69	PRKCQ	0.59158231
70	ERBB3	0.58746558
71	CSNK2A1	0.55989391
72	MKNK2	0.54497471
73	NME2	0.54161783
74	MAPKAPK3	0.54142144
75	AURKB	0.53967177
76	CSNK2A2	0.51922031
77	GRK7	0.49535577
78	RPS6KB2	0.48850286
79	TAOK3	0.48568189
80	OBSCN	0.47481290
81	CHEK2	0.46950787
82	PNCK	0.43632645
83	ATM	0.43368409
84	PIK3CG	0.42063627
85	JAK3	0.41951427
86	ADRBK1	0.41566278
87	PRKD3	0.41515293
88	PHKG2	0.41140776
89	PHKG1	0.41140776
90	MAPKAPK5	0.40401563
91	SCYL2	0.40100254
92	NEK2	0.37934620
93	MAP3K12	0.34850344
94	CASK	0.34071398
95	NEK6	0.33561579
96	MAP2K7	0.32853862
97	PRKCA	0.29868899
98	CDK4	0.28437111
99	PRKCE	0.28041216
100	CHEK1	0.27952356

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.47096489
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.84078385
3	One carbon pool by folate_Homo sapiens_hsa00670	2.77296672
4	RNA polymerase_Homo sapiens_hsa03020	2.39714658
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.38017125
6	Mismatch repair_Homo sapiens_hsa03430	2.31006068
7	Homologous recombination_Homo sapiens_hsa03440	2.26094421
8	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.20932371
9	DNA replication_Homo sapiens_hsa03030	2.15509690
10	Protein export_Homo sapiens_hsa03060	2.03870240
11	Basal transcription factors_Homo sapiens_hsa03022	1.95815115
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.94278394
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.92913653
14	Parkinsons disease_Homo sapiens_hsa05012	1.92404044
15	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.91973160
16	Spliceosome_Homo sapiens_hsa03040	1.86112809
17	Base excision repair_Homo sapiens_hsa03410	1.85973858
18	RNA transport_Homo sapiens_hsa03013	1.79460343
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.75910155
20	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.64764286
21	RNA degradation_Homo sapiens_hsa03018	1.63153773
22	Non-homologous end-joining_Homo sapiens_hsa03450	1.62427243
23	Sulfur metabolism_Homo sapiens_hsa00920	1.61068404
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.57822276
25	Propanoate metabolism_Homo sapiens_hsa00640	1.56768359
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.53120690
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.48135139
28	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.38046135
29	Peroxisome_Homo sapiens_hsa04146	1.35092438
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.33979757
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.33552260
32	Primary immunodeficiency_Homo sapiens_hsa05340	1.30497537
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.28308587
34	Purine metabolism_Homo sapiens_hsa00230	1.27033431
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.25348009
36	Huntingtons disease_Homo sapiens_hsa05016	1.24370878
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.14856714
38	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.13996465
39	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.13955886
40	Arginine biosynthesis_Homo sapiens_hsa00220	1.13209705
41	Ribosome_Homo sapiens_hsa03010	1.11421955
42	Type I diabetes mellitus_Homo sapiens_hsa04940	1.10641604
43	Phototransduction_Homo sapiens_hsa04744	1.09787788
44	Butanoate metabolism_Homo sapiens_hsa00650	1.06118474
45	Allograft rejection_Homo sapiens_hsa05330	1.03020119
46	mRNA surveillance pathway_Homo sapiens_hsa03015	1.02709906
47	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.02392741
48	Tryptophan metabolism_Homo sapiens_hsa00380	1.01477273
49	Graft-versus-host disease_Homo sapiens_hsa05332	1.01058160
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00117825
51	Alzheimers disease_Homo sapiens_hsa05010	0.96431171
52	Carbon metabolism_Homo sapiens_hsa01200	0.96048897
53	Antigen processing and presentation_Homo sapiens_hsa04612	0.92833001
54	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.89945181
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.88519127
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87056029
57	Retinol metabolism_Homo sapiens_hsa00830	0.84370712
58	Olfactory transduction_Homo sapiens_hsa04740	0.84284890
59	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83267587
60	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.82462738
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.80359269
62	Sulfur relay system_Homo sapiens_hsa04122	0.79328990
63	Caffeine metabolism_Homo sapiens_hsa00232	0.78712732
64	Asthma_Homo sapiens_hsa05310	0.77772133
65	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.77057472
66	Metabolic pathways_Homo sapiens_hsa01100	0.75555329
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.75460981
68	Folate biosynthesis_Homo sapiens_hsa00790	0.74328823
69	Glutathione metabolism_Homo sapiens_hsa00480	0.73579999
70	Arginine and proline metabolism_Homo sapiens_hsa00330	0.72891449
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.71054467
72	Rheumatoid arthritis_Homo sapiens_hsa05323	0.69418008
73	Linoleic acid metabolism_Homo sapiens_hsa00591	0.68310485
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66057688
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.63205841
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62289825
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.61151459
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.59714456
79	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57401161
80	Regulation of autophagy_Homo sapiens_hsa04140	0.56187401
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.54181837
82	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.50805147
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50399915
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49710195
85	Phenylalanine metabolism_Homo sapiens_hsa00360	0.49396091
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49002457
87	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48274819
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.47174174
89	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.46261809
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.45232158
91	Cardiac muscle contraction_Homo sapiens_hsa04260	0.43598101
92	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.43468875
93	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42271422
94	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.41312158
95	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39539941
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38423496
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.38138478
98	Fatty acid degradation_Homo sapiens_hsa00071	0.37778258
99	Fatty acid elongation_Homo sapiens_hsa00062	0.37754311
100	Taste transduction_Homo sapiens_hsa04742	0.36346118

HNRNPCP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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