ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	8.75395458
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	8.43313109
3	cytidine deamination (GO:0009972)	8.27437905
4	cytidine metabolic process (GO:0046087)	8.27437905
5	cytidine catabolic process (GO:0006216)	8.27437905
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	7.03100603
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.39941342
8	ATP synthesis coupled proton transport (GO:0015986)	4.83903225
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.83903225
10	regulation of regulatory T cell differentiation (GO:0045589)	4.60625078
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.14153695
12	proteasome assembly (GO:0043248)	4.06819004
13	protein neddylation (GO:0045116)	4.04646146
14	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.03073348
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.86803492
16	respiratory electron transport chain (GO:0022904)	3.82230336
17	electron transport chain (GO:0022900)	3.80830146
18	sequestering of actin monomers (GO:0042989)	3.71344729
19	actin nucleation (GO:0045010)	3.70909267
20	regulation of cellular amino acid metabolic process (GO:0006521)	3.69204042
21	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.55677949
22	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.53742228
23	positive regulation of interleukin-17 production (GO:0032740)	3.47067976
24	chaperone-mediated protein transport (GO:0072321)	3.43418129
25	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.42136351
26	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.42136351
27	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.40194824
28	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.40194824
29	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.40194824
30	metallo-sulfur cluster assembly (GO:0031163)	3.38549074
31	iron-sulfur cluster assembly (GO:0016226)	3.38549074
32	negative regulation of T cell apoptotic process (GO:0070233)	3.33067274
33	pyrimidine nucleoside catabolic process (GO:0046135)	3.32751879
34	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.30623691
35	termination of RNA polymerase III transcription (GO:0006386)	3.30623691
36	negative regulation of ligase activity (GO:0051352)	3.25876214
37	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.25876214
38	regulation of chronic inflammatory response (GO:0002676)	3.23442996
39	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.22114558
40	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.21449300
41	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.19937262
42	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.19597800
43	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.19597800
44	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.14470619
45	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.12919554
46	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.08480610
47	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.06773829
48	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.06773829
49	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.02913594
50	piRNA metabolic process (GO:0034587)	3.01418639
51	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.95661319
52	platelet dense granule organization (GO:0060155)	2.93317316
53	positive regulation of defense response to virus by host (GO:0002230)	2.92870927
54	positive regulation of tolerance induction (GO:0002645)	2.92406162
55	negative regulation of viral genome replication (GO:0045071)	2.88034753
56	respiratory chain complex IV assembly (GO:0008535)	2.87369726
57	protein complex biogenesis (GO:0070271)	2.86345283
58	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.85944888
59	DNA double-strand break processing (GO:0000729)	2.84662894
60	regulation of isotype switching to IgG isotypes (GO:0048302)	2.83926344
61	positive regulation of natural killer cell differentiation (GO:0032825)	2.83022845
62	organelle disassembly (GO:1903008)	2.82761165
63	ATP biosynthetic process (GO:0006754)	2.81002468
64	rRNA modification (GO:0000154)	2.78372078
65	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.77589866
66	S-adenosylmethionine metabolic process (GO:0046500)	2.77581091
67	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.77260537
68	water-soluble vitamin biosynthetic process (GO:0042364)	2.76203349
69	hydrogen ion transmembrane transport (GO:1902600)	2.75886270
70	centriole replication (GO:0007099)	2.75878652
71	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.73775643
72	negative regulation by host of viral transcription (GO:0043922)	2.73500803
73	regulation of cellular amine metabolic process (GO:0033238)	2.73210396
74	regulation of activation of Janus kinase activity (GO:0010533)	2.71639455
75	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.69924514
76	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.68261384
77	positive regulation of B cell differentiation (GO:0045579)	2.67440607
78	axoneme assembly (GO:0035082)	2.67138533
79	regulation of cilium movement (GO:0003352)	2.66079166
80	proton transport (GO:0015992)	2.65709146
81	regulation of T cell tolerance induction (GO:0002664)	2.64594742
82	cytochrome complex assembly (GO:0017004)	2.63614829
83	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.63168138
84	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.61957851
85	positive regulation of cell cycle arrest (GO:0071158)	2.61885434
86	hydrogen transport (GO:0006818)	2.60825462
87	mitochondrial respiratory chain complex assembly (GO:0033108)	2.60368367
88	pyrimidine-containing compound catabolic process (GO:0072529)	2.57309088
89	protein deneddylation (GO:0000338)	2.56775485
90	positive regulation of ligase activity (GO:0051351)	2.56325976
91	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.53405443
92	histone mRNA metabolic process (GO:0008334)	2.52689292
93	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.51411295
94	mannosylation (GO:0097502)	2.50313065
95	protein-cofactor linkage (GO:0018065)	2.50148658
96	positive regulation of calcium-mediated signaling (GO:0050850)	2.48946010
97	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.48911516
98	regulation of viral genome replication (GO:0045069)	2.46795123
99	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.44401551
100	DNA demethylation (GO:0080111)	2.44325415

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.81053627
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.79591352
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.63839910
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.33455697
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.21822783
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.11688162
7	VDR_22108803_ChIP-Seq_LS180_Human	2.99941542
8	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.97910842
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.70749717
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.62951818
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.52779577
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.50757234
13	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.37363877
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.24077459
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.22094751
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.19519372
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.17227330
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.15655682
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.15432519
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.14832230
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12991875
22	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.05241524
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.91497414
24	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.87923829
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.86188339
26	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.82109863
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.80591573
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.79767526
29	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.77269141
30	EWS_26573619_Chip-Seq_HEK293_Human	1.76334908
31	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.69793770
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.63759581
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.60752316
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.58640132
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.58014425
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.50209173
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48030100
38	MYB_26560356_Chip-Seq_TH2_Human	1.44489517
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.44120920
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43536327
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43536327
42	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.40882653
43	AR_20517297_ChIP-Seq_VCAP_Human	1.39871171
44	GATA3_26560356_Chip-Seq_TH2_Human	1.38990026
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35792519
46	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.31489798
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.31193320
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.27568431
49	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27283983
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.26189735
51	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.24091014
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23598795
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.22458768
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.22458768
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21867779
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21867779
57	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.20710364
58	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.19927686
59	NCOR_22424771_ChIP-Seq_293T_Human	1.18417005
60	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.15066516
61	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.13857538
62	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13687618
63	P300_19829295_ChIP-Seq_ESCs_Human	1.13094987
64	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12469432
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09503182
66	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.09443365
67	GATA3_27048872_Chip-Seq_THYMUS_Human	1.08123130
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08114215
69	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.07137782
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06465709
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06453203
72	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.05355544
73	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05171676
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04471353
75	MYC_19829295_ChIP-Seq_ESCs_Human	1.04094341
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04055828
77	ERG_20517297_ChIP-Seq_VCAP_Human	1.03080893
78	RUNX_20019798_ChIP-Seq_JUKART_Human	1.03057712
79	FUS_26573619_Chip-Seq_HEK293_Human	1.02778281
80	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.02528137
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02473646
82	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.02454409
83	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.01547388
84	RBPJ_21746931_ChIP-Seq_IB4_Human	1.00593307
85	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00447545
86	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00372543
87	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.00298690
88	GATA3_26560356_Chip-Seq_TH1_Human	0.99263787
89	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.98466505
90	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98031715
91	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97644446
92	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97002305
93	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.97000045
94	BCAT_22108803_ChIP-Seq_LS180_Human	0.96239821
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95225891
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93806935
97	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.93167266
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93132204
99	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.92723093
100	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92112914

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.84546929
2	MP0002102_abnormal_ear_morphology	3.16561647
3	MP0009379_abnormal_foot_pigmentation	3.11058962
4	MP0008877_abnormal_DNA_methylation	2.64841263
5	MP0001188_hyperpigmentation	2.62201827
6	MP0001873_stomach_inflammation	2.32568125
7	MP0009785_altered_susceptibility_to	2.31944356
8	MP0006072_abnormal_retinal_apoptosis	2.31441011
9	MP0009333_abnormal_splenocyte_physiolog	2.24081548
10	MP0001835_abnormal_antigen_presentation	2.13537139
11	MP0000372_irregular_coat_pigmentation	1.97319380
12	MP0003786_premature_aging	1.86968180
13	MP0005645_abnormal_hypothalamus_physiol	1.83934111
14	MP0005000_abnormal_immune_tolerance	1.76896987
15	MP0003195_calcinosis	1.76590951
16	MP0008789_abnormal_olfactory_epithelium	1.74939831
17	MP0004147_increased_porphyrin_level	1.74502795
18	MP0008058_abnormal_DNA_repair	1.72738032
19	MP0008995_early_reproductive_senescence	1.70182683
20	MP0002138_abnormal_hepatobiliary_system	1.66886165
21	MP0002166_altered_tumor_susceptibility	1.65117722
22	MP0009697_abnormal_copulation	1.64327440
23	MP0003763_abnormal_thymus_physiology	1.63349526
24	MP0001905_abnormal_dopamine_level	1.63071992
25	MP0006292_abnormal_olfactory_placode	1.61350083
26	MP0006082_CNS_inflammation	1.56924211
27	MP0002148_abnormal_hypersensitivity_rea	1.53862831
28	MP0001968_abnormal_touch/_nociception	1.48794489
29	MP0002006_tumorigenesis	1.43581563
30	MP0002876_abnormal_thyroid_physiology	1.43521058
31	MP0005253_abnormal_eye_physiology	1.42651950
32	MP0003724_increased_susceptibility_to	1.42440511
33	MP0005389_reproductive_system_phenotype	1.41984563
34	MP0001800_abnormal_humoral_immune	1.39915019
35	MP0002723_abnormal_immune_serum	1.39201981
36	MP0002420_abnormal_adaptive_immunity	1.37788762
37	MP0002277_abnormal_respiratory_mucosa	1.36941294
38	MP0006036_abnormal_mitochondrial_physio	1.36419520
39	MP0001485_abnormal_pinna_reflex	1.36407129
40	MP0003880_abnormal_central_pattern	1.36398502
41	MP0003718_maternal_effect	1.34576458
42	MP0005551_abnormal_eye_electrophysiolog	1.33502307
43	MP0001819_abnormal_immune_cell	1.31099686
44	MP0002837_dystrophic_cardiac_calcinosis	1.28798119
45	MP0005084_abnormal_gallbladder_morpholo	1.27945256
46	MP0002736_abnormal_nociception_after	1.26330182
47	MP0005085_abnormal_gallbladder_physiolo	1.26025111
48	MP0002160_abnormal_reproductive_system	1.23030842
49	MP0001529_abnormal_vocalization	1.22821245
50	MP0008872_abnormal_physiological_respon	1.22445996
51	MP0002405_respiratory_system_inflammati	1.21475707
52	MP0001984_abnormal_olfaction	1.20779351
53	MP0001986_abnormal_taste_sensitivity	1.20171921
54	MP0002234_abnormal_pharynx_morphology	1.19953841
55	MP0001919_abnormal_reproductive_system	1.19432040
56	MP0005025_abnormal_response_to	1.15716832
57	MP0005410_abnormal_fertilization	1.12337582
58	MP0003011_delayed_dark_adaptation	1.11774287
59	MP0008875_abnormal_xenobiotic_pharmacok	1.07700084
60	MP0009046_muscle_twitch	1.04703529
61	MP0003806_abnormal_nucleotide_metabolis	1.04513139
62	MP0000716_abnormal_immune_system	1.02830817
63	MP0006035_abnormal_mitochondrial_morpho	1.02760468
64	MP0003646_muscle_fatigue	1.02253737
65	MP0003137_abnormal_impulse_conducting	1.01842371
66	MP0002452_abnormal_antigen_presenting	1.00591305
67	MP0001845_abnormal_inflammatory_respons	1.00305014
68	MP0005499_abnormal_olfactory_system	0.99625261
69	MP0005394_taste/olfaction_phenotype	0.99625261
70	MP0005379_endocrine/exocrine_gland_phen	0.99553703
71	MP0002398_abnormal_bone_marrow	0.99138102
72	MP0005360_urolithiasis	0.98509805
73	MP0001853_heart_inflammation	0.98030418
74	MP0009745_abnormal_behavioral_response	0.96205279
75	MP0001929_abnormal_gametogenesis	0.96158634
76	MP0002272_abnormal_nervous_system	0.95327413
77	MP0005174_abnormal_tail_pigmentation	0.94657342
78	MP0009764_decreased_sensitivity_to	0.93157880
79	MP0000703_abnormal_thymus_morphology	0.92585003
80	MP0005646_abnormal_pituitary_gland	0.89481406
81	MP0005387_immune_system_phenotype	0.88085357
82	MP0001790_abnormal_immune_system	0.88085357
83	MP0000689_abnormal_spleen_morphology	0.87364280
84	MP0005075_abnormal_melanosome_morpholog	0.87145357
85	MP0002653_abnormal_ependyma_morphology	0.86917121
86	MP0001661_extended_life_span	0.86584220
87	MP0010155_abnormal_intestine_physiology	0.86292747
88	MP0002210_abnormal_sex_determination	0.86248479
89	MP0004145_abnormal_muscle_electrophysio	0.85736495
90	MP0003866_abnormal_defecation	0.84794309
91	MP0003567_abnormal_fetal_cardiomyocyte	0.84000990
92	MP0002722_abnormal_immune_system	0.83263809
93	MP0003252_abnormal_bile_duct	0.82831446
94	MP0006276_abnormal_autonomic_nervous	0.82555150
95	MP0001501_abnormal_sleep_pattern	0.81761024
96	MP0002638_abnormal_pupillary_reflex	0.81382079
97	MP0001119_abnormal_female_reproductive	0.79273400
98	MP0000465_gastrointestinal_hemorrhage	0.79008779
99	MP0002429_abnormal_blood_cell	0.77589689
100	MP0008057_abnormal_DNA_replication	0.76976143

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	4.71323959
2	Acute necrotizing encephalopathy (HP:0006965)	4.61698331
3	Mitochondrial inheritance (HP:0001427)	4.42979604
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.16353222
5	Acute encephalopathy (HP:0006846)	3.94741603
6	Increased CSF lactate (HP:0002490)	3.89215706
7	Progressive macrocephaly (HP:0004481)	3.88211479
8	3-Methylglutaconic aciduria (HP:0003535)	3.80104685
9	Hepatocellular necrosis (HP:0001404)	3.76920436
10	Increased hepatocellular lipid droplets (HP:0006565)	3.61561220
11	Elevated erythrocyte sedimentation rate (HP:0003565)	3.51218079
12	Lipid accumulation in hepatocytes (HP:0006561)	3.42334089
13	T lymphocytopenia (HP:0005403)	3.38228349
14	Cerebral edema (HP:0002181)	3.35624222
15	Hepatic necrosis (HP:0002605)	3.30820371
16	Severe combined immunodeficiency (HP:0004430)	3.27961747
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.25811250
18	IgG deficiency (HP:0004315)	3.25767385
19	Pancreatic cysts (HP:0001737)	3.17631864
20	Abnormality of midbrain morphology (HP:0002418)	3.14081487
21	Molar tooth sign on MRI (HP:0002419)	3.14081487
22	Abnormality of T cell number (HP:0011839)	3.12878577
23	Renal Fanconi syndrome (HP:0001994)	3.00059758
24	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.88176008
25	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.88176008
26	Decreased central vision (HP:0007663)	2.79622306
27	Hypoproteinemia (HP:0003075)	2.76554912
28	Increased intramyocellular lipid droplets (HP:0012240)	2.75879152
29	Optic disc pallor (HP:0000543)	2.75118935
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.66491954
31	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.62365761
32	Type I transferrin isoform profile (HP:0003642)	2.60253708
33	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.54904631
34	Combined immunodeficiency (HP:0005387)	2.54671186
35	Congenital, generalized hypertrichosis (HP:0004540)	2.54341005
36	Increased serum lactate (HP:0002151)	2.51848328
37	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.51515707
38	Exertional dyspnea (HP:0002875)	2.51282129
39	Attenuation of retinal blood vessels (HP:0007843)	2.46220970
40	Respiratory failure (HP:0002878)	2.44378359
41	Lactic acidosis (HP:0003128)	2.41729312
42	Pancreatic fibrosis (HP:0100732)	2.39912788
43	Congenital stationary night blindness (HP:0007642)	2.39829645
44	Abolished electroretinogram (ERG) (HP:0000550)	2.37769571
45	True hermaphroditism (HP:0010459)	2.37698792
46	Thyroiditis (HP:0100646)	2.35852678
47	Type II lissencephaly (HP:0007260)	2.35722981
48	Abnormality of the prostate (HP:0008775)	2.35457579
49	Increased muscle lipid content (HP:0009058)	2.33069243
50	Abnormality of B cell number (HP:0010975)	2.20959143
51	Medial flaring of the eyebrow (HP:0010747)	2.20805011
52	B lymphocytopenia (HP:0010976)	2.18777521
53	Lethargy (HP:0001254)	2.14753839
54	Aplasia/hypoplasia of the uterus (HP:0008684)	2.14385120
55	Abnormality of T cells (HP:0002843)	2.12949359
56	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.09631840
57	Exercise intolerance (HP:0003546)	2.08957944
58	Pendular nystagmus (HP:0012043)	2.07255321
59	Abnormality of urine glucose concentration (HP:0011016)	2.07207520
60	Glycosuria (HP:0003076)	2.07207520
61	Nephronophthisis (HP:0000090)	2.01798362
62	Chronic diarrhea (HP:0002028)	2.00268518
63	Increased IgM level (HP:0003496)	1.97146857
64	Posterior subcapsular cataract (HP:0007787)	1.96252579
65	Hypothermia (HP:0002045)	1.94556392
66	Leukodystrophy (HP:0002415)	1.94172758
67	Abnormality of renal resorption (HP:0011038)	1.94135066
68	Short tibia (HP:0005736)	1.93725250
69	Stomatitis (HP:0010280)	1.93104535
70	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.92385563
71	Abnormal protein N-linked glycosylation (HP:0012347)	1.92385563
72	Abnormal protein glycosylation (HP:0012346)	1.92385563
73	Abnormal glycosylation (HP:0012345)	1.92385563
74	Abnormality of eosinophils (HP:0001879)	1.91507695
75	Pancytopenia (HP:0001876)	1.90129140
76	Median cleft lip (HP:0000161)	1.89454755
77	Methylmalonic acidemia (HP:0002912)	1.85601472
78	Renal cortical cysts (HP:0000803)	1.84701702
79	X-linked dominant inheritance (HP:0001423)	1.79236146
80	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.78618304
81	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.75718377
82	Gangrene (HP:0100758)	1.74388809
83	Parakeratosis (HP:0001036)	1.73789961
84	Alveolar cell carcinoma (HP:0006519)	1.72659227
85	Autoimmune hemolytic anemia (HP:0001890)	1.71837501
86	Respiratory difficulties (HP:0002880)	1.71215433
87	Methylmalonic aciduria (HP:0012120)	1.70895680
88	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.69174215
89	Optic neuritis (HP:0100653)	1.68931223
90	Retrobulbar optic neuritis (HP:0100654)	1.68931223
91	Spastic paraparesis (HP:0002313)	1.68393586
92	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.68198597
93	Hypoplasia of the fovea (HP:0007750)	1.68198597
94	Abnormality of the fovea (HP:0000493)	1.67924837
95	Reduced antithrombin III activity (HP:0001976)	1.66823630
96	Hyperphosphaturia (HP:0003109)	1.66808445
97	Abnormal albumin level (HP:0012116)	1.66195873
98	Hypoalbuminemia (HP:0003073)	1.66195873
99	Neoplasm of the tracheobronchial system (HP:0100552)	1.65067733
100	Hypoplasia of the uterus (HP:0000013)	1.64378794

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.76637525
2	KDR	3.65882946
3	TESK2	3.16892931
4	NUAK1	3.12222358
5	VRK2	3.05984122
6	MAP4K2	3.04823826
7	BCKDK	2.97539921
8	EIF2AK3	2.41637661
9	TIE1	2.30940387
10	BUB1	2.23202031
11	VRK1	2.21444284
12	ZAK	2.15221399
13	PINK1	2.13774355
14	ADRBK2	2.13179544
15	TAOK3	1.90473280
16	GRK1	1.89806899
17	MST4	1.87727150
18	FES	1.71780827
19	TLK1	1.67439757
20	CDK19	1.65062898
21	MAP3K12	1.43340628
22	TEC	1.40266650
23	SRPK1	1.37047335
24	PLK4	1.36158042
25	ITK	1.26734542
26	OXSR1	1.26276371
27	FRK	1.25654196
28	TESK1	1.23540083
29	CSNK1G1	1.18306600
30	CSNK1G3	1.14594486
31	TRIM28	1.12666214
32	SCYL2	1.11052864
33	CDC7	1.08929001
34	BMPR2	1.03007686
35	WNK4	0.99204857
36	PRKCQ	0.98600979
37	GRK6	0.94426811
38	CSNK1A1L	0.93261360
39	INSRR	0.93126520
40	RPS6KA4	0.91162776
41	STK39	0.90950714
42	IKBKB	0.87706164
43	WNK3	0.86436603
44	PLK3	0.82241913
45	LIMK1	0.81067097
46	CSK	0.80663411
47	CSNK1G2	0.80479348
48	DAPK1	0.79461056
49	LCK	0.76235157
50	MAP4K1	0.76227676
51	MATK	0.74978841
52	RPS6KA5	0.73216340
53	PLK2	0.69562119
54	ERBB3	0.68744102
55	MAPKAPK3	0.67090637
56	BCR	0.66079916
57	EIF2AK2	0.65055301
58	LYN	0.62981771
59	SYK	0.62960470
60	NEK1	0.61999812
61	MYLK	0.61638272
62	BMPR1B	0.61630857
63	PIM2	0.53688234
64	GRK7	0.51752661
65	MAPK13	0.49689779
66	MAP2K6	0.49631378
67	KIT	0.47859601
68	CSNK1A1	0.47025292
69	BTK	0.46717782
70	ATR	0.44220371
71	CAMKK2	0.43329344
72	DYRK3	0.43321827
73	ARAF	0.43160384
74	PLK1	0.42811954
75	STK16	0.42628211
76	PRKACA	0.41717021
77	CSNK2A1	0.41695792
78	CAMK2A	0.40928360
79	PRKCE	0.40427452
80	CSNK2A2	0.40146748
81	NME1	0.40109708
82	DYRK2	0.39896892
83	PIM1	0.39689515
84	OBSCN	0.37766119
85	CLK1	0.37644310
86	AURKB	0.37266969
87	MUSK	0.36130847
88	RAF1	0.35985204
89	MKNK1	0.35853763
90	MINK1	0.35214848
91	PRKCA	0.34097783
92	INSR	0.32372074
93	ROCK1	0.31749817
94	IGF1R	0.31718694
95	AURKA	0.30857895
96	MAPKAPK5	0.28856013
97	PRKCG	0.28764037
98	ADRBK1	0.26605186
99	PAK1	0.26108989
100	PIK3CG	0.25685306

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.97553364
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.69662019
3	Parkinsons disease_Homo sapiens_hsa05012	3.24607872
4	Primary immunodeficiency_Homo sapiens_hsa05340	3.17728396
5	Protein export_Homo sapiens_hsa03060	3.10287429
6	RNA polymerase_Homo sapiens_hsa03020	2.91138534
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.29700921
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.24116830
9	Allograft rejection_Homo sapiens_hsa05330	2.06466707
10	Huntingtons disease_Homo sapiens_hsa05016	2.04940548
11	Alzheimers disease_Homo sapiens_hsa05010	2.02099709
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.95814960
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.85832868
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.80471783
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.73309890
16	Asthma_Homo sapiens_hsa05310	1.68762091
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.67533102
18	Ribosome_Homo sapiens_hsa03010	1.67256213
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.56786530
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.48871524
21	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.48676357
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.43367613
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.41197462
24	Fatty acid elongation_Homo sapiens_hsa00062	1.38700373
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.36918447
26	Spliceosome_Homo sapiens_hsa03040	1.34853700
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34662402
28	RNA degradation_Homo sapiens_hsa03018	1.29763751
29	Homologous recombination_Homo sapiens_hsa03440	1.27998562
30	Butanoate metabolism_Homo sapiens_hsa00650	1.27777894
31	Phototransduction_Homo sapiens_hsa04744	1.25572438
32	Rheumatoid arthritis_Homo sapiens_hsa05323	1.24286046
33	Propanoate metabolism_Homo sapiens_hsa00640	1.21342359
34	Peroxisome_Homo sapiens_hsa04146	1.19789789
35	Basal transcription factors_Homo sapiens_hsa03022	1.17368802
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.17122377
37	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.14591314
38	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.06630717
39	Mismatch repair_Homo sapiens_hsa03430	1.06299326
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.05450774
41	Sulfur metabolism_Homo sapiens_hsa00920	1.01261854
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00345198
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.99380935
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98490924
45	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.98434563
46	Regulation of autophagy_Homo sapiens_hsa04140	0.95681699
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.94834052
48	RNA transport_Homo sapiens_hsa03013	0.92722514
49	One carbon pool by folate_Homo sapiens_hsa00670	0.89851324
50	Purine metabolism_Homo sapiens_hsa00230	0.89669658
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.87319320
52	Olfactory transduction_Homo sapiens_hsa04740	0.77151689
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.75490170
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75187527
55	Fanconi anemia pathway_Homo sapiens_hsa03460	0.74380939
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72836655
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.72795772
58	DNA replication_Homo sapiens_hsa03030	0.72294049
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70191363
60	Fatty acid degradation_Homo sapiens_hsa00071	0.68104214
61	Nucleotide excision repair_Homo sapiens_hsa03420	0.67866777
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66572912
63	Linoleic acid metabolism_Homo sapiens_hsa00591	0.64882550
64	Retinol metabolism_Homo sapiens_hsa00830	0.64508976
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.62276609
66	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.62263179
67	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.61723805
68	Caffeine metabolism_Homo sapiens_hsa00232	0.61506356
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60917159
70	Viral myocarditis_Homo sapiens_hsa05416	0.60693196
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59642090
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58420955
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56314475
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55174658
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55165988
76	Metabolic pathways_Homo sapiens_hsa01100	0.54677874
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53552211
78	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53515413
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52364527
80	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47496882
81	Non-homologous end-joining_Homo sapiens_hsa03450	0.46068168
82	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.44059653
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43605600
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43146323
85	Folate biosynthesis_Homo sapiens_hsa00790	0.43018476
86	Nicotine addiction_Homo sapiens_hsa05033	0.42312991
87	Base excision repair_Homo sapiens_hsa03410	0.41491651
88	Steroid biosynthesis_Homo sapiens_hsa00100	0.40982400
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40975731
90	Selenocompound metabolism_Homo sapiens_hsa00450	0.40926461
91	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.39040863
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.38570524
93	Malaria_Homo sapiens_hsa05144	0.37218677
94	Measles_Homo sapiens_hsa05162	0.37040341
95	Pyruvate metabolism_Homo sapiens_hsa00620	0.36053850
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.34169744
97	Taste transduction_Homo sapiens_hsa04742	0.31538828
98	ABC transporters_Homo sapiens_hsa02010	0.28632606
99	mRNA surveillance pathway_Homo sapiens_hsa03015	0.26452421
100	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.25325921

HNRNPCP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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