ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	8.41935890
2	cytidine metabolic process (GO:0046087)	7.72561319
3	cytidine catabolic process (GO:0006216)	7.72561319
4	cytidine deamination (GO:0009972)	7.72561319
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	7.60861069
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	6.75516323
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.83284944
8	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.61987837
9	sequestering of actin monomers (GO:0042989)	4.36194759
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.30602738
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.25288334
12	ATP synthesis coupled proton transport (GO:0015986)	4.25288334
13	actin nucleation (GO:0045010)	4.16395818
14	regulation of cellular amino acid metabolic process (GO:0006521)	4.07565899
15	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	4.02131436
16	proteasome assembly (GO:0043248)	3.96526720
17	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.88657597
18	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.88657597
19	respiratory electron transport chain (GO:0022904)	3.87931891
20	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.86721729
21	electron transport chain (GO:0022900)	3.81784245
22	protein neddylation (GO:0045116)	3.78167997
23	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.76094981
24	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.76094981
25	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.76094981
26	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.75532143
27	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.74999990
28	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.74999990
29	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.72920311
30	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.61889286
31	negative regulation of ligase activity (GO:0051352)	3.56949952
32	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.56949952
33	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.54416256
34	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.54416256
35	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.53656399
36	negative regulation of T cell apoptotic process (GO:0070233)	3.51646508
37	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.49031466
38	protein deneddylation (GO:0000338)	3.46560568
39	negative regulation by host of viral transcription (GO:0043922)	3.46138522
40	cullin deneddylation (GO:0010388)	3.34847829
41	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.34684651
42	regulation of regulatory T cell differentiation (GO:0045589)	3.29081518
43	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.28890141
44	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.26125334
45	platelet dense granule organization (GO:0060155)	3.25039200
46	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.24662701
47	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.20295158
48	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.17039695
49	termination of RNA polymerase III transcription (GO:0006386)	3.17039695
50	metallo-sulfur cluster assembly (GO:0031163)	3.16049770
51	iron-sulfur cluster assembly (GO:0016226)	3.16049770
52	pyrimidine nucleoside catabolic process (GO:0046135)	3.12778018
53	positive regulation of ligase activity (GO:0051351)	3.07312575
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.04925538
55	protein complex biogenesis (GO:0070271)	3.04087873
56	mannosylation (GO:0097502)	2.98086097
57	respiratory chain complex IV assembly (GO:0008535)	2.97433495
58	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.94928358
59	positive regulation of B cell differentiation (GO:0045579)	2.90900722
60	cellular response to interleukin-15 (GO:0071350)	2.89727491
61	eosinophil chemotaxis (GO:0048245)	2.88498672
62	rRNA modification (GO:0000154)	2.87953489
63	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.87574232
64	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.87111277
65	regulation of cellular amine metabolic process (GO:0033238)	2.86567212
66	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.84965009
67	positive regulation of cell cycle arrest (GO:0071158)	2.84765246
68	protein-cofactor linkage (GO:0018065)	2.83633305
69	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.77250239
70	cytochrome complex assembly (GO:0017004)	2.76798605
71	negative regulation of viral genome replication (GO:0045071)	2.76165608
72	negative T cell selection (GO:0043383)	2.75723158
73	branched-chain amino acid catabolic process (GO:0009083)	2.74912361
74	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.73139144
75	positive regulation of interleukin-8 secretion (GO:2000484)	2.72649446
76	positive regulation of calcium-mediated signaling (GO:0050850)	2.72252152
77	positive thymic T cell selection (GO:0045059)	2.72079954
78	hydrogen ion transmembrane transport (GO:1902600)	2.68975042
79	mitochondrial respiratory chain complex assembly (GO:0033108)	2.68960190
80	cytolysis (GO:0019835)	2.68627761
81	chaperone-mediated protein transport (GO:0072321)	2.67625862
82	water-soluble vitamin biosynthetic process (GO:0042364)	2.64770735
83	positive T cell selection (GO:0043368)	2.64548617
84	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.64377944
85	ATP biosynthetic process (GO:0006754)	2.62979927
86	regulation of chronic inflammatory response (GO:0002676)	2.62825088
87	oxidative phosphorylation (GO:0006119)	2.62742370
88	eosinophil migration (GO:0072677)	2.62348564
89	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.61438263
90	NADH dehydrogenase complex assembly (GO:0010257)	2.61438263
91	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.61438263
92	regulation of isotype switching to IgG isotypes (GO:0048302)	2.61339098
93	DNA demethylation (GO:0080111)	2.60331887
94	regulation of ligase activity (GO:0051340)	2.59615498
95	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.59565231
96	T cell migration (GO:0072678)	2.58250441
97	GPI anchor biosynthetic process (GO:0006506)	2.56878363
98	proton transport (GO:0015992)	2.56078825
99	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.55504163
100	regulation of natural killer cell mediated immunity (GO:0002715)	2.55504163

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.14192731
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.43207061
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.22818212
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.94458702
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.41850854
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.11534525
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.95164154
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.93378772
9	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.89943951
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.73712611
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.50127166
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.49403109
13	VDR_22108803_ChIP-Seq_LS180_Human	2.47350766
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.40661261
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.39885272
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.34339331
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.29814125
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.23927972
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.17970206
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.05720705
21	ZNF274_21170338_ChIP-Seq_K562_Hela	2.03982855
22	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.00675637
23	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.93930767
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.92515031
25	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.91833548
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.85178230
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77149489
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68455888
29	MYB_26560356_Chip-Seq_TH2_Human	1.62466455
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.61230104
31	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.59286412
32	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.54066382
33	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.52741767
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.51486268
35	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.50765447
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.46138983
37	GATA3_26560356_Chip-Seq_TH2_Human	1.40655411
38	EWS_26573619_Chip-Seq_HEK293_Human	1.39728817
39	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.38156486
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.37518542
41	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.36692697
42	HTT_18923047_ChIP-ChIP_STHdh_Human	1.36302582
43	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.36261853
44	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.34844889
45	GATA3_27048872_Chip-Seq_THYMUS_Human	1.29321533
46	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.29154385
47	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.29113132
48	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.28890448
49	AR_20517297_ChIP-Seq_VCAP_Human	1.28670248
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.28599654
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28346489
52	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.26383638
53	GABP_19822575_ChIP-Seq_HepG2_Human	1.26283612
54	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22981766
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22379051
56	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.21879059
57	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.21764279
58	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.20573828
59	DCP1A_22483619_ChIP-Seq_HELA_Human	1.18273330
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.17166402
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16863605
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16863605
63	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.16614027
64	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.16050273
65	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10275001
66	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.10271352
67	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.08665961
68	ERG_20517297_ChIP-Seq_VCAP_Human	1.06710759
69	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.06707193
70	NCOR_22424771_ChIP-Seq_293T_Human	1.06117991
71	TAF15_26573619_Chip-Seq_HEK293_Human	1.06117326
72	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.05806106
73	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.04818572
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04429443
75	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04429443
76	IRF1_19129219_ChIP-ChIP_H3396_Human	1.04383010
77	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.04002608
78	E2F7_22180533_ChIP-Seq_HELA_Human	1.03640836
79	ER_23166858_ChIP-Seq_MCF-7_Human	1.02536895
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02251210
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02085208
82	CBP_20019798_ChIP-Seq_JUKART_Human	1.02085208
83	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.01348864
84	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.00900540
85	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.00366465
86	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.00101553
87	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.00097003
88	FUS_26573619_Chip-Seq_HEK293_Human	1.00063572
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00029498
90	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99833593
91	GATA3_26560356_Chip-Seq_TH1_Human	0.98981317
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98650593
93	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.97710281
94	CIITA_25753668_ChIP-Seq_RAJI_Human	0.97104243
95	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.96820641
96	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95937923
97	TTF2_22483619_ChIP-Seq_HELA_Human	0.95394206
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94879049
99	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.94396891
100	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.92926025

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.43649418
2	MP0002102_abnormal_ear_morphology	3.04239630
3	MP0006072_abnormal_retinal_apoptosis	2.59898642
4	MP0008877_abnormal_DNA_methylation	2.49188902
5	MP0009785_altered_susceptibility_to	2.41998834
6	MP0004147_increased_porphyrin_level	2.40058721
7	MP0009333_abnormal_splenocyte_physiolog	2.23939908
8	MP0000372_irregular_coat_pigmentation	2.14807415
9	MP0008995_early_reproductive_senescence	2.12648475
10	MP0001835_abnormal_antigen_presentation	2.03147888
11	MP0005645_abnormal_hypothalamus_physiol	2.00329314
12	MP0008058_abnormal_DNA_repair	1.97923212
13	MP0005646_abnormal_pituitary_gland	1.95626466
14	MP0003763_abnormal_thymus_physiology	1.95134118
15	MP0003786_premature_aging	1.87893065
16	MP0009697_abnormal_copulation	1.81140194
17	MP0005000_abnormal_immune_tolerance	1.77081048
18	MP0005253_abnormal_eye_physiology	1.74340210
19	MP0001984_abnormal_olfaction	1.71905995
20	MP0002837_dystrophic_cardiac_calcinosis	1.69784550
21	MP0008789_abnormal_olfactory_epithelium	1.68767930
22	MP0006292_abnormal_olfactory_placode	1.68663052
23	MP0003195_calcinosis	1.65981653
24	MP0001800_abnormal_humoral_immune	1.65090627
25	MP0003880_abnormal_central_pattern	1.63864546
26	MP0002166_altered_tumor_susceptibility	1.59048031
27	MP0002148_abnormal_hypersensitivity_rea	1.58879851
28	MP0006082_CNS_inflammation	1.55303193
29	MP0003787_abnormal_imprinting	1.53939658
30	MP0002420_abnormal_adaptive_immunity	1.51983557
31	MP0008872_abnormal_physiological_respon	1.51394969
32	MP0002723_abnormal_immune_serum	1.51298515
33	MP0001764_abnormal_homeostasis	1.47237005
34	MP0003011_delayed_dark_adaptation	1.47175110
35	MP0005379_endocrine/exocrine_gland_phen	1.45650229
36	MP0001819_abnormal_immune_cell	1.45485423
37	MP0005551_abnormal_eye_electrophysiolog	1.44958821
38	MP0001790_abnormal_immune_system	1.41620957
39	MP0005387_immune_system_phenotype	1.41620957
40	MP0002277_abnormal_respiratory_mucosa	1.40844086
41	MP0001905_abnormal_dopamine_level	1.40516777
42	MP0006035_abnormal_mitochondrial_morpho	1.38114405
43	MP0002163_abnormal_gland_morphology	1.37615685
44	MP0001529_abnormal_vocalization	1.36722863
45	MP0006036_abnormal_mitochondrial_physio	1.34671188
46	MP0005025_abnormal_response_to	1.32464373
47	MP0001873_stomach_inflammation	1.30718788
48	MP0004145_abnormal_muscle_electrophysio	1.30678538
49	MP0005360_urolithiasis	1.28487534
50	MP0002006_tumorigenesis	1.27585006
51	MP0000689_abnormal_spleen_morphology	1.24327630
52	MP0002398_abnormal_bone_marrow	1.23705217
53	MP0006276_abnormal_autonomic_nervous	1.22313934
54	MP0001968_abnormal_touch/_nociception	1.21547078
55	MP0002138_abnormal_hepatobiliary_system	1.21480922
56	MP0001919_abnormal_reproductive_system	1.19593185
57	MP0002452_abnormal_antigen_presenting	1.18069767
58	MP0000716_abnormal_immune_system	1.18021718
59	MP0002736_abnormal_nociception_after	1.17836575
60	MP0005410_abnormal_fertilization	1.17688419
61	MP0003866_abnormal_defecation	1.17507867
62	MP0001661_extended_life_span	1.16860205
63	MP0008875_abnormal_xenobiotic_pharmacok	1.16464261
64	MP0000703_abnormal_thymus_morphology	1.15275364
65	MP0005084_abnormal_gallbladder_morpholo	1.14380404
66	MP0004142_abnormal_muscle_tone	1.13730061
67	MP0002405_respiratory_system_inflammati	1.12012019
68	MP0002722_abnormal_immune_system	1.10447279
69	MP0005389_reproductive_system_phenotype	1.10159004
70	MP0005636_abnormal_mineral_homeostasis	1.04817349
71	MP0005075_abnormal_melanosome_morpholog	0.99907343
72	MP0001845_abnormal_inflammatory_respons	0.99555617
73	MP0000685_abnormal_immune_system	0.99342291
74	MP0005377_hearing/vestibular/ear_phenot	0.97274954
75	MP0003878_abnormal_ear_physiology	0.97274954
76	MP0010094_abnormal_chromosome_stability	0.96019121
77	MP0003137_abnormal_impulse_conducting	0.94487437
78	MP0002095_abnormal_skin_pigmentation	0.93734885
79	MP0005499_abnormal_olfactory_system	0.93593419
80	MP0005394_taste/olfaction_phenotype	0.93593419
81	MP0002429_abnormal_blood_cell	0.92330093
82	MP0005332_abnormal_amino_acid	0.92224411
83	MP0002693_abnormal_pancreas_physiology	0.91151698
84	MP0002876_abnormal_thyroid_physiology	0.90234255
85	MP0010155_abnormal_intestine_physiology	0.89845098
86	MP0003045_fibrosis	0.89640343
87	MP0004957_abnormal_blastocyst_morpholog	0.87208887
88	MP0003186_abnormal_redox_activity	0.87087763
89	MP0002234_abnormal_pharynx_morphology	0.85367522
90	MP0005083_abnormal_biliary_tract	0.85334591
91	MP0002638_abnormal_pupillary_reflex	0.84345338
92	MP0001853_heart_inflammation	0.84262075
93	MP0001485_abnormal_pinna_reflex	0.83308039
94	MP0003806_abnormal_nucleotide_metabolis	0.80678569
95	MP0009745_abnormal_behavioral_response	0.79309175
96	MP0001929_abnormal_gametogenesis	0.77586253
97	MP0008469_abnormal_protein_level	0.76955790
98	MP0009764_decreased_sensitivity_to	0.76034667
99	MP0009046_muscle_twitch	0.75740372
100	MP0001119_abnormal_female_reproductive	0.75717148

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	4.63193746
2	Mitochondrial inheritance (HP:0001427)	4.23294991
3	Acute necrotizing encephalopathy (HP:0006965)	4.23089187
4	Severe combined immunodeficiency (HP:0004430)	3.98919021
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.82034190
6	Hepatocellular necrosis (HP:0001404)	3.81671715
7	3-Methylglutaconic aciduria (HP:0003535)	3.78223800
8	Increased CSF lactate (HP:0002490)	3.73465930
9	Progressive macrocephaly (HP:0004481)	3.67053059
10	IgG deficiency (HP:0004315)	3.62370787
11	Acute encephalopathy (HP:0006846)	3.58562443
12	T lymphocytopenia (HP:0005403)	3.55464204
13	Hepatic necrosis (HP:0002605)	3.44308295
14	Abnormality of T cell number (HP:0011839)	3.36248559
15	Increased hepatocellular lipid droplets (HP:0006565)	3.31917067
16	Cerebral edema (HP:0002181)	3.26354042
17	Combined immunodeficiency (HP:0005387)	3.16334011
18	Thyroiditis (HP:0100646)	3.11249732
19	Pancreatic cysts (HP:0001737)	3.06592887
20	Lipid accumulation in hepatocytes (HP:0006561)	3.00485496
21	Hypoproteinemia (HP:0003075)	2.90343665
22	Autoimmune hemolytic anemia (HP:0001890)	2.78050020
23	True hermaphroditism (HP:0010459)	2.77657071
24	Increased IgM level (HP:0003496)	2.77159678
25	Increased intramyocellular lipid droplets (HP:0012240)	2.76165179
26	Abnormality of T cells (HP:0002843)	2.73342294
27	Type I transferrin isoform profile (HP:0003642)	2.71393811
28	Increased serum lactate (HP:0002151)	2.69424188
29	Abnormality of midbrain morphology (HP:0002418)	2.68710257
30	Molar tooth sign on MRI (HP:0002419)	2.68710257
31	Attenuation of retinal blood vessels (HP:0007843)	2.67773133
32	Lactic acidosis (HP:0003128)	2.65985588
33	Pancreatic fibrosis (HP:0100732)	2.63605279
34	Abnormality of eosinophils (HP:0001879)	2.61919391
35	Elevated erythrocyte sedimentation rate (HP:0003565)	2.53501527
36	Renal Fanconi syndrome (HP:0001994)	2.51917377
37	Chronic diarrhea (HP:0002028)	2.49357494
38	Pancytopenia (HP:0001876)	2.46220388
39	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.43756031
40	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.43756031
41	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.41486662
42	Optic disc pallor (HP:0000543)	2.40303353
43	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.39980789
44	Abolished electroretinogram (ERG) (HP:0000550)	2.38375872
45	Respiratory failure (HP:0002878)	2.34274183
46	Lethargy (HP:0001254)	2.34132790
47	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32405007
48	Abnormality of alanine metabolism (HP:0010916)	2.32405007
49	Hyperalaninemia (HP:0003348)	2.32405007
50	Abnormal glycosylation (HP:0012345)	2.28143319
51	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.28143319
52	Abnormal protein N-linked glycosylation (HP:0012347)	2.28143319
53	Abnormal protein glycosylation (HP:0012346)	2.28143319
54	Methylmalonic acidemia (HP:0002912)	2.26494746
55	Increased muscle lipid content (HP:0009058)	2.26393913
56	Methylmalonic aciduria (HP:0012120)	2.21392717
57	Decreased central vision (HP:0007663)	2.20790654
58	Congenital stationary night blindness (HP:0007642)	2.19662606
59	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.15000082
60	Renal cortical cysts (HP:0000803)	2.13212247
61	Abnormal rod and cone electroretinograms (HP:0008323)	2.11309918
62	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.11168662
63	Constricted visual fields (HP:0001133)	2.10667524
64	B lymphocytopenia (HP:0010976)	2.09985342
65	Exertional dyspnea (HP:0002875)	2.09266487
66	Dicarboxylic aciduria (HP:0003215)	2.09147342
67	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.09147342
68	Exercise intolerance (HP:0003546)	2.07223949
69	Eosinophilia (HP:0001880)	2.07169633
70	Aplasia/hypoplasia of the uterus (HP:0008684)	2.07009158
71	Abnormality of B cell number (HP:0010975)	2.06389319
72	Abnormality of the prostate (HP:0008775)	2.06090021
73	Medial flaring of the eyebrow (HP:0010747)	2.04026656
74	Ketoacidosis (HP:0001993)	2.03957318
75	Nephronophthisis (HP:0000090)	2.02186607
76	Ketosis (HP:0001946)	2.01943048
77	CNS demyelination (HP:0007305)	1.98365619
78	Hypothermia (HP:0002045)	1.95724787
79	Nephrogenic diabetes insipidus (HP:0009806)	1.88262605
80	Hypomagnesemia (HP:0002917)	1.88103046
81	Pendular nystagmus (HP:0012043)	1.86494600
82	Hyperglycinemia (HP:0002154)	1.85979428
83	Generalized aminoaciduria (HP:0002909)	1.84539929
84	Granulocytopenia (HP:0001913)	1.82837483
85	Type 2 muscle fiber atrophy (HP:0003554)	1.82467647
86	Abnormality of the renal cortex (HP:0011035)	1.80417770
87	Hypoalbuminemia (HP:0003073)	1.80314486
88	Abnormal albumin level (HP:0012116)	1.80314486
89	Recurrent cutaneous fungal infections (HP:0011370)	1.78537352
90	Chronic mucocutaneous candidiasis (HP:0002728)	1.78537352
91	Emotional lability (HP:0000712)	1.78530296
92	Type II lissencephaly (HP:0007260)	1.76938569
93	Abnormality of T cell physiology (HP:0011840)	1.75835283
94	Chronic sinusitis (HP:0011109)	1.75337347
95	Encephalitis (HP:0002383)	1.74642382
96	Congenital primary aphakia (HP:0007707)	1.72225235
97	Leukocytosis (HP:0001974)	1.71106818
98	Leukodystrophy (HP:0002415)	1.70454945
99	Abnormality of serum amino acid levels (HP:0003112)	1.70062849
100	Cerebral hypomyelination (HP:0006808)	1.69041788

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.78649812
2	KDR	4.44562650
3	TESK2	3.94462516
4	BCKDK	3.55129030
5	ZAK	3.11333483
6	VRK2	2.68656991
7	MAP4K2	2.58402680
8	BUB1	2.33334563
9	TRIM28	2.30875717
10	MST4	2.23026490
11	VRK1	2.17338126
12	FRK	2.11243020
13	ADRBK2	2.00827400
14	TLK1	1.88391860
15	BCR	1.80332648
16	EIF2AK3	1.73395329
17	ITK	1.69883432
18	NUAK1	1.65052811
19	SRPK1	1.52577327
20	LIMK1	1.49523340
21	TESK1	1.49411836
22	MAP4K1	1.49207509
23	MAP2K7	1.43155310
24	GRK1	1.40961074
25	CSNK1G3	1.23369016
26	RPS6KA4	1.23014099
27	INSRR	1.16786810
28	WNK3	1.10306197
29	CSNK1G1	1.10032911
30	PINK1	1.04804871
31	MAP3K4	1.04384669
32	SCYL2	1.02599477
33	TAOK3	1.01894788
34	SYK	0.97225077
35	PRKCQ	0.95926652
36	GRK6	0.93942723
37	FES	0.93360214
38	TEC	0.91394805
39	CSNK1A1L	0.91084840
40	PLK2	0.90956024
41	PLK3	0.90365915
42	CSNK1G2	0.88306437
43	PLK4	0.85811173
44	TNK2	0.83793645
45	MAPK13	0.82893280
46	WNK4	0.81347084
47	DAPK1	0.79572395
48	MUSK	0.78873583
49	ERBB3	0.78506966
50	LCK	0.77173807
51	RPS6KA5	0.74564710
52	NME1	0.74504786
53	LYN	0.73574978
54	MAP3K12	0.65753911
55	MATK	0.64256402
56	DYRK2	0.63161621
57	IKBKB	0.60107303
58	ATR	0.57676079
59	EIF2AK1	0.55833330
60	TIE1	0.55226362
61	PLK1	0.54018157
62	GRK7	0.53065570
63	MAPKAPK3	0.52565726
64	CCNB1	0.52455018
65	PIK3CG	0.51320107
66	BMPR2	0.51112705
67	BTK	0.49608813
68	CSNK1A1	0.48854560
69	PHKG1	0.48572860
70	PHKG2	0.48572860
71	CSNK2A1	0.46295877
72	CAMKK2	0.45982158
73	PIM1	0.45438848
74	PDK2	0.44366589
75	MAP3K5	0.44153995
76	NLK	0.43358786
77	PRKCE	0.43248700
78	CSK	0.41236163
79	EPHA3	0.40510319
80	CSNK2A2	0.39120662
81	AURKA	0.37379429
82	IKBKE	0.37372322
83	PRKCA	0.36188368
84	PIM2	0.35790986
85	BMPR1B	0.35703299
86	TSSK6	0.35143797
87	PRKACA	0.35038736
88	OBSCN	0.34400875
89	OXSR1	0.34349285
90	CDC7	0.33642243
91	MAPKAPK5	0.33024793
92	EPHA4	0.32366361
93	ZAP70	0.31962754
94	AURKB	0.31559303
95	PAK1	0.30939990
96	JAK3	0.30770584
97	IGF1R	0.30710825
98	DAPK2	0.30595944
99	MYLK	0.29785843
100	ROCK1	0.28487771

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.27085613
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.74015878
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.71472707
4	Parkinsons disease_Homo sapiens_hsa05012	3.17226106
5	Protein export_Homo sapiens_hsa03060	2.84340559
6	RNA polymerase_Homo sapiens_hsa03020	2.83619722
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.23084042
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14519793
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.04900017
10	Antigen processing and presentation_Homo sapiens_hsa04612	1.97009662
11	Alzheimers disease_Homo sapiens_hsa05010	1.96624476
12	Huntingtons disease_Homo sapiens_hsa05016	1.95508946
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.95282381
14	Allograft rejection_Homo sapiens_hsa05330	1.94467434
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.94039366
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.87696455
17	Homologous recombination_Homo sapiens_hsa03440	1.79248351
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.77305054
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.67099984
20	Butanoate metabolism_Homo sapiens_hsa00650	1.63582772
21	Mismatch repair_Homo sapiens_hsa03430	1.58193655
22	Propanoate metabolism_Homo sapiens_hsa00640	1.57481874
23	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.39233363
24	Spliceosome_Homo sapiens_hsa03040	1.35670095
25	Ribosome_Homo sapiens_hsa03010	1.34255874
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.33616598
27	DNA replication_Homo sapiens_hsa03030	1.33260467
28	RNA degradation_Homo sapiens_hsa03018	1.32669079
29	Fatty acid elongation_Homo sapiens_hsa00062	1.30415347
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.27368186
31	Phototransduction_Homo sapiens_hsa04744	1.21375430
32	One carbon pool by folate_Homo sapiens_hsa00670	1.15925593
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.14170475
34	Peroxisome_Homo sapiens_hsa04146	1.12884309
35	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.10467352
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.09128437
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08932773
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.08867820
39	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.08422180
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.07671473
41	Nucleotide excision repair_Homo sapiens_hsa03420	1.02967179
42	RNA transport_Homo sapiens_hsa03013	1.00962412
43	Purine metabolism_Homo sapiens_hsa00230	0.99895217
44	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.99098978
45	Non-homologous end-joining_Homo sapiens_hsa03450	0.97587200
46	Asthma_Homo sapiens_hsa05310	0.97368089
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.94893144
48	Caffeine metabolism_Homo sapiens_hsa00232	0.94520118
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87987689
50	Basal transcription factors_Homo sapiens_hsa03022	0.85694132
51	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.85068365
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.84656630
53	Sulfur metabolism_Homo sapiens_hsa00920	0.84339694
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78135284
55	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.77960069
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.77506513
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76482694
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.74128495
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.72038625
60	Base excision repair_Homo sapiens_hsa03410	0.71589952
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.71128910
62	Olfactory transduction_Homo sapiens_hsa04740	0.66742335
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.65661209
64	Regulation of autophagy_Homo sapiens_hsa04140	0.64120294
65	Folate biosynthesis_Homo sapiens_hsa00790	0.63378209
66	Metabolic pathways_Homo sapiens_hsa01100	0.62413061
67	Retinol metabolism_Homo sapiens_hsa00830	0.60365207
68	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.55498854
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.53985864
70	Measles_Homo sapiens_hsa05162	0.53674380
71	Taste transduction_Homo sapiens_hsa04742	0.53012544
72	Linoleic acid metabolism_Homo sapiens_hsa00591	0.52009310
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51647087
74	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.50874920
75	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.50379444
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.49457831
77	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.49059618
78	Viral myocarditis_Homo sapiens_hsa05416	0.48781251
79	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.46811537
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.46610459
81	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46062448
82	Shigellosis_Homo sapiens_hsa05131	0.45456304
83	Salmonella infection_Homo sapiens_hsa05132	0.42475363
84	Nicotine addiction_Homo sapiens_hsa05033	0.42175546
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.41460649
86	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39618490
87	Pyruvate metabolism_Homo sapiens_hsa00620	0.38843406
88	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.38369599
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.36688904
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35105340
91	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.32829675
92	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.30736314
93	mRNA surveillance pathway_Homo sapiens_hsa03015	0.29021290
94	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.26729683
95	Fatty acid degradation_Homo sapiens_hsa00071	0.26142587
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.24047773
97	Selenocompound metabolism_Homo sapiens_hsa00450	0.23980889
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.23659140
99	Carbon metabolism_Homo sapiens_hsa01200	0.23065041
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.22838925

HNRNPCP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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