ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.86239218
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.85931414
3	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.85931414
4	proteasome assembly (GO:0043248)	4.56586430
5	respiratory chain complex IV assembly (GO:0008535)	4.00579817
6	water-soluble vitamin biosynthetic process (GO:0042364)	3.93532575
7	rRNA modification (GO:0000154)	3.89953609
8	cullin deneddylation (GO:0010388)	3.85494248
9	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.84501234
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.82018746
11	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.82018746
12	NADH dehydrogenase complex assembly (GO:0010257)	3.82018746
13	mitochondrial RNA metabolic process (GO:0000959)	3.79968694
14	platelet dense granule organization (GO:0060155)	3.68849204
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.63359360
16	ATP synthesis coupled proton transport (GO:0015986)	3.63359360
17	protein deneddylation (GO:0000338)	3.58569940
18	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.58326002
19	protein complex biogenesis (GO:0070271)	3.53790787
20	mitochondrial respiratory chain complex assembly (GO:0033108)	3.51397634
21	folic acid-containing compound biosynthetic process (GO:0009396)	3.48689780
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.47951763
23	behavioral response to nicotine (GO:0035095)	3.44838344
24	adenosine metabolic process (GO:0046085)	3.43496443
25	preassembly of GPI anchor in ER membrane (GO:0016254)	3.43276109
26	protein-cofactor linkage (GO:0018065)	3.36652311
27	rRNA methylation (GO:0031167)	3.34903070
28	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.33884037
29	regulation of cellular amino acid metabolic process (GO:0006521)	3.32624386
30	tRNA processing (GO:0008033)	3.28253280
31	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.26342649
32	amino acid salvage (GO:0043102)	3.24530296
33	L-methionine salvage (GO:0071267)	3.24530296
34	L-methionine biosynthetic process (GO:0071265)	3.24530296
35	DNA catabolic process, exonucleolytic (GO:0000738)	3.19418806
36	protein neddylation (GO:0045116)	3.18893588
37	tRNA modification (GO:0006400)	3.18331593
38	pseudouridine synthesis (GO:0001522)	3.16884969
39	fucose catabolic process (GO:0019317)	3.09010524
40	L-fucose metabolic process (GO:0042354)	3.09010524
41	L-fucose catabolic process (GO:0042355)	3.09010524
42	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.08033409
43	IMP biosynthetic process (GO:0006188)	3.04351217
44	chaperone-mediated protein transport (GO:0072321)	3.02268434
45	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.00584690
46	cytochrome complex assembly (GO:0017004)	2.99850562
47	cytidine deamination (GO:0009972)	2.97122443
48	cytidine metabolic process (GO:0046087)	2.97122443
49	cytidine catabolic process (GO:0006216)	2.97122443
50	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.96546479
51	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.96546479
52	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.96546479
53	regulation of isotype switching to IgG isotypes (GO:0048302)	2.95816910
54	cellular ketone body metabolic process (GO:0046950)	2.94777862
55	tRNA metabolic process (GO:0006399)	2.94032139
56	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.92357701
57	regulation of mitotic spindle checkpoint (GO:1903504)	2.90972911
58	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.90972911
59	mannosylation (GO:0097502)	2.90696389
60	piRNA metabolic process (GO:0034587)	2.89924337
61	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.89682618
62	termination of RNA polymerase III transcription (GO:0006386)	2.89578625
63	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.89578625
64	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.89401399
65	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.89401399
66	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.89104919
67	kynurenine metabolic process (GO:0070189)	2.82343048
68	GPI anchor metabolic process (GO:0006505)	2.79008760
69	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.78526023
70	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.78526023
71	branched-chain amino acid catabolic process (GO:0009083)	2.77751315
72	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.77305112
73	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.75221657
74	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.74879931
75	negative regulation of ligase activity (GO:0051352)	2.74879931
76	DNA double-strand break processing (GO:0000729)	2.74531886
77	purine nucleotide salvage (GO:0032261)	2.74098319
78	GPI anchor biosynthetic process (GO:0006506)	2.73913658
79	protein targeting to mitochondrion (GO:0006626)	2.70967876
80	positive regulation of defense response to virus by host (GO:0002230)	2.67796724
81	DNA damage response, detection of DNA damage (GO:0042769)	2.67327302
82	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.66432276
83	electron transport chain (GO:0022900)	2.65963774
84	organelle disassembly (GO:1903008)	2.63878139
85	establishment of protein localization to mitochondrion (GO:0072655)	2.63448085
86	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.63330460
87	respiratory electron transport chain (GO:0022904)	2.63028371
88	prenylation (GO:0097354)	2.62348261
89	protein prenylation (GO:0018342)	2.62348261
90	protein localization to mitochondrion (GO:0070585)	2.61667069
91	positive regulation of interleukin-17 production (GO:0032740)	2.58754346
92	S-adenosylmethionine metabolic process (GO:0046500)	2.58664668
93	ketone body metabolic process (GO:1902224)	2.58604876
94	GTP biosynthetic process (GO:0006183)	2.58579413
95	IMP metabolic process (GO:0046040)	2.57158773
96	regulation of immunoglobulin secretion (GO:0051023)	2.56912121
97	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.53155144
98	methionine biosynthetic process (GO:0009086)	2.53134418
99	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.52278827
100	regulation of cilium movement (GO:0003352)	2.49822888

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.46139424
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.75805638
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.26978908
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.55856134
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.28377672
6	VDR_22108803_ChIP-Seq_LS180_Human	3.21028162
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.18219669
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.15885498
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.05601446
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.83619834
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.79427312
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.73170690
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.65373469
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.52116236
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.29835736
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.27242642
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.24860129
18	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.20611919
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.19349080
20	IGF1R_20145208_ChIP-Seq_DFB_Human	2.07270188
21	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.00477617
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.95342598
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86516935
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.82360576
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.81730477
26	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.67239820
27	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.59669078
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.57465115
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.56572085
30	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.55887380
31	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.55650183
32	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.53806325
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.53497110
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.53291575
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.50916806
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.50351465
37	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.49275445
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.48355869
39	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.48203782
40	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.44299538
41	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.44142746
42	GATA3_26560356_Chip-Seq_TH2_Human	1.42649205
43	EWS_26573619_Chip-Seq_HEK293_Human	1.39641068
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.37572729
45	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.35964979
46	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32738961
47	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.32185484
48	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.30611774
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28539194
50	AR_20517297_ChIP-Seq_VCAP_Human	1.27975725
51	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.27037243
52	DCP1A_22483619_ChIP-Seq_HELA_Human	1.26684768
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23889039
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22637929
55	E2F7_22180533_ChIP-Seq_HELA_Human	1.22422985
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21605517
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21605517
58	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.18770167
59	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.18079360
60	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.17804654
61	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.15134311
62	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.13343880
63	FUS_26573619_Chip-Seq_HEK293_Human	1.11399887
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10082930
65	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.06770753
66	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06564198
67	TTF2_22483619_ChIP-Seq_HELA_Human	1.06165174
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05376250
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05376250
70	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.04764816
71	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.04641626
72	CBP_20019798_ChIP-Seq_JUKART_Human	1.03385746
73	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.03385746
74	ER_23166858_ChIP-Seq_MCF-7_Human	1.02914725
75	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.02363228
76	NCOR_22424771_ChIP-Seq_293T_Human	1.02111117
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01603373
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.97996066
79	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.97397350
80	MYB_26560356_Chip-Seq_TH2_Human	0.97105602
81	XRN2_22483619_ChIP-Seq_HELA_Human	0.96881978
82	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.96165462
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95902338
84	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.95581377
85	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.94160034
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94126988
87	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.94051155
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.93936324
89	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.93767274
90	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92766617
91	GATA3_26560356_Chip-Seq_TH1_Human	0.92281535
92	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92209001
93	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.90158498
94	GBX2_23144817_ChIP-Seq_PC3_Human	0.89819012
95	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.89270296
96	P300_19829295_ChIP-Seq_ESCs_Human	0.89054233
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.88027842
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.87458768
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87243669
100	KDM5A_27292631_Chip-Seq_BREAST_Human	0.86283618

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	4.20697762
2	MP0005645_abnormal_hypothalamus_physiol	3.95944223
3	MP0004147_increased_porphyrin_level	3.88991800
4	MP0008877_abnormal_DNA_methylation	3.05572166
5	MP0002102_abnormal_ear_morphology	2.90070476
6	MP0006072_abnormal_retinal_apoptosis	2.61897544
7	MP0003786_premature_aging	2.54025377
8	MP0008875_abnormal_xenobiotic_pharmacok	2.41185091
9	MP0003724_increased_susceptibility_to	2.23840420
10	MP0008995_early_reproductive_senescence	2.17252669
11	MP0002736_abnormal_nociception_after	2.16271806
12	MP0008872_abnormal_physiological_respon	2.14827937
13	MP0005084_abnormal_gallbladder_morpholo	2.05749925
14	MP0002138_abnormal_hepatobiliary_system	2.02800268
15	MP0001968_abnormal_touch/_nociception	1.89614863
16	MP0004885_abnormal_endolymph	1.87554266
17	MP0003646_muscle_fatigue	1.80575943
18	MP0008058_abnormal_DNA_repair	1.78741613
19	MP0005671_abnormal_response_to	1.77928543
20	MP0003718_maternal_effect	1.77777287
21	MP0005551_abnormal_eye_electrophysiolog	1.75617450
22	MP0002148_abnormal_hypersensitivity_rea	1.75576737
23	MP0010094_abnormal_chromosome_stability	1.67215802
24	MP0001835_abnormal_antigen_presentation	1.67110111
25	MP0002006_tumorigenesis	1.66560470
26	MP0005253_abnormal_eye_physiology	1.63169281
27	MP0006035_abnormal_mitochondrial_morpho	1.57543539
28	MP0001984_abnormal_olfaction	1.55552593
29	MP0001986_abnormal_taste_sensitivity	1.51946909
30	MP0002837_dystrophic_cardiac_calcinosis	1.48797586
31	MP0009764_decreased_sensitivity_to	1.43965984
32	MP0005167_abnormal_blood-brain_barrier	1.36306059
33	MP0002277_abnormal_respiratory_mucosa	1.34037060
34	MP0003195_calcinosis	1.33791789
35	MP0000013_abnormal_adipose_tissue	1.33481951
36	MP0003693_abnormal_embryo_hatching	1.31192956
37	MP0006036_abnormal_mitochondrial_physio	1.29709208
38	MP0002876_abnormal_thyroid_physiology	1.26723376
39	MP0001661_extended_life_span	1.25064177
40	MP0001800_abnormal_humoral_immune	1.25049444
41	MP0005389_reproductive_system_phenotype	1.22759665
42	MP0001501_abnormal_sleep_pattern	1.22686084
43	MP0004145_abnormal_muscle_electrophysio	1.22037057
44	MP0002166_altered_tumor_susceptibility	1.21135272
45	MP0006292_abnormal_olfactory_placode	1.21037519
46	MP0001529_abnormal_vocalization	1.20904114
47	MP0001764_abnormal_homeostasis	1.20165888
48	MP0002160_abnormal_reproductive_system	1.19614645
49	MP0003866_abnormal_defecation	1.18263534
50	MP0001905_abnormal_dopamine_level	1.16943395
51	MP0002272_abnormal_nervous_system	1.13729098
52	MP0003186_abnormal_redox_activity	1.13179821
53	MP0005000_abnormal_immune_tolerance	1.12619963
54	MP0009333_abnormal_splenocyte_physiolog	1.10666560
55	MP0002735_abnormal_chemical_nociception	1.07828198
56	MP0000372_irregular_coat_pigmentation	1.07283697
57	MP0003806_abnormal_nucleotide_metabolis	1.06953549
58	MP0009745_abnormal_behavioral_response	1.01818253
59	MP0006276_abnormal_autonomic_nervous	1.01567247
60	MP0004043_abnormal_pH_regulation	1.00676322
61	MP0009785_altered_susceptibility_to	1.00619927
62	MP0008775_abnormal_heart_ventricle	0.96928118
63	MP0003011_delayed_dark_adaptation	0.96296480
64	MP0005332_abnormal_amino_acid	0.94628740
65	MP0001919_abnormal_reproductive_system	0.92404448
66	MP0004957_abnormal_blastocyst_morpholog	0.92357836
67	MP0003878_abnormal_ear_physiology	0.91490724
68	MP0005377_hearing/vestibular/ear_phenot	0.91490724
69	MP0004133_heterotaxia	0.91041037
70	MP0002723_abnormal_immune_serum	0.90836482
71	MP0001853_heart_inflammation	0.90611270
72	MP0005360_urolithiasis	0.88165487
73	MP0002452_abnormal_antigen_presenting	0.86519100
74	MP0005647_abnormal_sex_gland	0.86176427
75	MP0000631_abnormal_neuroendocrine_gland	0.86174594
76	MP0001486_abnormal_startle_reflex	0.85428244
77	MP0002733_abnormal_thermal_nociception	0.83316819
78	MP0003763_abnormal_thymus_physiology	0.83243513
79	MP0000465_gastrointestinal_hemorrhage	0.82905146
80	MP0000647_abnormal_sebaceous_gland	0.79913452
81	MP0003252_abnormal_bile_duct	0.79496316
82	MP0004142_abnormal_muscle_tone	0.78017549
83	MP0001790_abnormal_immune_system	0.77423323
84	MP0005387_immune_system_phenotype	0.77423323
85	MP0005636_abnormal_mineral_homeostasis	0.74975797
86	MP0000685_abnormal_immune_system	0.74938303
87	MP0008057_abnormal_DNA_replication	0.74523800
88	MP0004215_abnormal_myocardial_fiber	0.73917847
89	MP0009046_muscle_twitch	0.73890628
90	MP0000689_abnormal_spleen_morphology	0.73252874
91	MP0001819_abnormal_immune_cell	0.72646493
92	MP0001243_abnormal_dermal_layer	0.71699001
93	MP0003787_abnormal_imprinting	0.71549267
94	MP0005670_abnormal_white_adipose	0.70817887
95	MP0002420_abnormal_adaptive_immunity	0.70496599
96	MP0001119_abnormal_female_reproductive	0.70258064
97	MP0005410_abnormal_fertilization	0.69792988
98	MP0001845_abnormal_inflammatory_respons	0.69006739
99	MP0002163_abnormal_gland_morphology	0.68514627
100	MP0001929_abnormal_gametogenesis	0.68462592

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	4.22107198
2	Hyperalaninemia (HP:0003348)	4.22107198
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.22107198
4	Acute necrotizing encephalopathy (HP:0006965)	3.72160607
5	Mitochondrial inheritance (HP:0001427)	3.59302975
6	Increased CSF lactate (HP:0002490)	3.54820691
7	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.46293942
8	Methylmalonic acidemia (HP:0002912)	3.44392018
9	Acute encephalopathy (HP:0006846)	3.35409777
10	Increased hepatocellular lipid droplets (HP:0006565)	3.33232456
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.30764484
12	Lipid accumulation in hepatocytes (HP:0006561)	3.29058425
13	3-Methylglutaconic aciduria (HP:0003535)	3.26689244
14	Hepatocellular necrosis (HP:0001404)	3.15173325
15	Elevated erythrocyte sedimentation rate (HP:0003565)	3.14544603
16	Progressive macrocephaly (HP:0004481)	3.03448023
17	IgG deficiency (HP:0004315)	2.99352248
18	Increased serum lactate (HP:0002151)	2.99304902
19	Renal cortical cysts (HP:0000803)	2.98467163
20	Hepatic necrosis (HP:0002605)	2.96867504
21	Methylmalonic aciduria (HP:0012120)	2.83302250
22	Pancreatic cysts (HP:0001737)	2.79300473
23	Pendular nystagmus (HP:0012043)	2.77586440
24	Lactic acidosis (HP:0003128)	2.75527901
25	Abnormality of serum amino acid levels (HP:0003112)	2.67510890
26	Tubulointerstitial nephritis (HP:0001970)	2.63888185
27	Constricted visual fields (HP:0001133)	2.60442579
28	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.60124987
29	Type 2 muscle fiber atrophy (HP:0003554)	2.58136953
30	Cerebral edema (HP:0002181)	2.57093488
31	True hermaphroditism (HP:0010459)	2.56398855
32	Pancreatic fibrosis (HP:0100732)	2.55719731
33	Opisthotonus (HP:0002179)	2.54282924
34	Nephronophthisis (HP:0000090)	2.49665602
35	Abnormality of the renal cortex (HP:0011035)	2.44821110
36	Progressive microcephaly (HP:0000253)	2.44781255
37	Abnormality of midbrain morphology (HP:0002418)	2.41095906
38	Molar tooth sign on MRI (HP:0002419)	2.41095906
39	Attenuation of retinal blood vessels (HP:0007843)	2.36697099
40	Type II lissencephaly (HP:0007260)	2.33059787
41	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.27113330
42	Type I transferrin isoform profile (HP:0003642)	2.26648131
43	Medial flaring of the eyebrow (HP:0010747)	2.25669561
44	Dicarboxylic aciduria (HP:0003215)	2.23642068
45	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.23642068
46	Abolished electroretinogram (ERG) (HP:0000550)	2.23342428
47	Chronic hepatic failure (HP:0100626)	2.21469950
48	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.20738146
49	Abnormality of the pons (HP:0007361)	2.18868205
50	Renal Fanconi syndrome (HP:0001994)	2.17884095
51	Abnormality of the renal medulla (HP:0100957)	2.17189772
52	Congenital stationary night blindness (HP:0007642)	2.17189632
53	Respiratory failure (HP:0002878)	2.17104911
54	Decreased central vision (HP:0007663)	2.14020361
55	Hyperglycinemia (HP:0002154)	2.13462152
56	Increased intramyocellular lipid droplets (HP:0012240)	2.12547574
57	Lethargy (HP:0001254)	2.12404563
58	Nausea (HP:0002018)	2.10918552
59	Keratoconus (HP:0000563)	2.10529255
60	Increased corneal curvature (HP:0100692)	2.10529255
61	Stomatitis (HP:0010280)	2.08161640
62	Inability to walk (HP:0002540)	2.07081785
63	Abnormal biliary tract physiology (HP:0012439)	2.05996202
64	Bile duct proliferation (HP:0001408)	2.05996202
65	Metabolic acidosis (HP:0001942)	2.05561855
66	Muscle fiber atrophy (HP:0100295)	2.04676586
67	Delayed CNS myelination (HP:0002188)	2.03971968
68	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.03524236
69	Optic disc pallor (HP:0000543)	2.03429633
70	Exercise intolerance (HP:0003546)	2.01089010
71	Duplicated collecting system (HP:0000081)	1.97633898
72	Homocystinuria (HP:0002156)	1.97029418
73	Abnormality of homocysteine metabolism (HP:0010919)	1.97029418
74	Exertional dyspnea (HP:0002875)	1.96134831
75	Cerebral palsy (HP:0100021)	1.95848498
76	Congenital, generalized hypertrichosis (HP:0004540)	1.94834167
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.94587008
78	Abnormal protein N-linked glycosylation (HP:0012347)	1.94587008
79	Abnormal protein glycosylation (HP:0012346)	1.94587008
80	Abnormal glycosylation (HP:0012345)	1.94587008
81	Hypoplasia of the pons (HP:0012110)	1.91852534
82	Abnormality of the renal collecting system (HP:0004742)	1.90618676
83	Abnormality of vitamin B metabolism (HP:0004340)	1.89947767
84	Microvesicular hepatic steatosis (HP:0001414)	1.89655400
85	Abnormality of urine glucose concentration (HP:0011016)	1.88670404
86	Glycosuria (HP:0003076)	1.88670404
87	Increased serum pyruvate (HP:0003542)	1.87649892
88	Stomach cancer (HP:0012126)	1.87019526
89	Degeneration of anterior horn cells (HP:0002398)	1.86006649
90	Abnormality of the anterior horn cell (HP:0006802)	1.86006649
91	Carpal bone hypoplasia (HP:0001498)	1.85369926
92	Panhypogammaglobulinemia (HP:0003139)	1.83588033
93	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.83189740
94	Increased muscle lipid content (HP:0009058)	1.82443384
95	Anorexia (HP:0002039)	1.78585705
96	Reduced antithrombin III activity (HP:0001976)	1.77713016
97	Abnormality of glycine metabolism (HP:0010895)	1.77399135
98	Abnormality of serine family amino acid metabolism (HP:0010894)	1.77399135
99	Testicular atrophy (HP:0000029)	1.76716489
100	Colon cancer (HP:0003003)	1.75330307

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.65380430
2	TLK1	3.33317190
3	ADRBK2	2.84184359
4	EIF2AK3	2.78654541
5	TXK	2.72590276
6	NUAK1	2.46165831
7	TAOK3	2.43665067
8	BUB1	2.34421944
9	VRK2	2.26912908
10	TIE1	2.22603135
11	MAP4K2	2.18512132
12	TSSK6	2.12782602
13	NEK1	1.69895378
14	GRK1	1.69883488
15	SRPK1	1.69757195
16	MST4	1.67550075
17	WNK4	1.56743909
18	VRK1	1.56473131
19	KDR	1.48299715
20	BCKDK	1.44185726
21	TEC	1.43140194
22	MKNK1	1.42532103
23	CSNK1G3	1.42219867
24	MAP3K14	1.36638628
25	STK16	1.28015075
26	CSNK1A1L	1.26177082
27	MAPKAPK5	1.23927959
28	IKBKB	1.23501060
29	BCR	1.22328306
30	NME1	1.22312241
31	CCNB1	1.22168330
32	CSNK1G1	1.21007258
33	CSNK1G2	1.20864579
34	PLK3	1.16322930
35	DAPK1	1.12558084
36	EIF2AK2	1.10476768
37	FRK	1.10273711
38	RPS6KA5	1.08919041
39	WNK3	1.07892725
40	MAP2K7	1.07252498
41	ITK	1.06717030
42	TESK2	1.05443861
43	PHKG2	1.03205526
44	PHKG1	1.03205526
45	FES	1.00876010
46	GRK6	0.99408138
47	ERBB3	0.98671929
48	TRIM28	0.98158081
49	EIF2AK1	0.97287140
50	PLK4	0.96179760
51	MAP4K1	0.94143991
52	MAPKAPK3	0.91134209
53	MAP3K4	0.90088972
54	ADRBK1	0.88873193
55	PINK1	0.87690585
56	BMPR2	0.86714383
57	CAMKK2	0.86533090
58	CLK1	0.84023278
59	ATR	0.84016094
60	BMPR1B	0.82773546
61	SYK	0.82163776
62	OXSR1	0.81702058
63	PBK	0.76440606
64	PLK2	0.76097304
65	PASK	0.73875391
66	TTK	0.68034760
67	TBK1	0.68031687
68	MAP2K2	0.64170112
69	PRKCQ	0.64089184
70	DYRK2	0.62133306
71	STK39	0.61534158
72	OBSCN	0.59330022
73	INSRR	0.56975512
74	PDK2	0.56192853
75	ALK	0.56016441
76	KIT	0.55248908
77	IKBKE	0.54056858
78	ACVR1B	0.53831566
79	TAF1	0.53052305
80	MAPK13	0.53036543
81	PIK3CA	0.53013674
82	JAK3	0.51646389
83	CSNK1A1	0.50274904
84	AURKB	0.50079788
85	PLK1	0.49672959
86	BTK	0.49568623
87	IRAK4	0.48678801
88	PIK3CG	0.47654317
89	LCK	0.45810442
90	CAMK2A	0.45665671
91	CSNK2A1	0.44908209
92	LYN	0.43306310
93	PRKCE	0.42898934
94	IGF1R	0.40937370
95	PRKCG	0.40369335
96	TNK2	0.39402087
97	CSNK2A2	0.38614221
98	MKNK2	0.37656741
99	CDK8	0.37519742
100	PRKCA	0.37314233

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.05897022
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.77536903
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.43642655
4	One carbon pool by folate_Homo sapiens_hsa00670	2.43537537
5	RNA polymerase_Homo sapiens_hsa03020	2.34871367
6	Parkinsons disease_Homo sapiens_hsa05012	2.33079302
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.30891758
8	Homologous recombination_Homo sapiens_hsa03440	2.11844288
9	Mismatch repair_Homo sapiens_hsa03430	2.00534720
10	Asthma_Homo sapiens_hsa05310	1.90330129
11	Protein export_Homo sapiens_hsa03060	1.90276225
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.87991907
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.72423784
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.69277126
15	DNA replication_Homo sapiens_hsa03030	1.68535765
16	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.67956492
17	RNA degradation_Homo sapiens_hsa03018	1.64110761
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.62056348
19	Spliceosome_Homo sapiens_hsa03040	1.61207121
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.54579820
21	Regulation of autophagy_Homo sapiens_hsa04140	1.53465778
22	Phototransduction_Homo sapiens_hsa04744	1.48151936
23	Basal transcription factors_Homo sapiens_hsa03022	1.47714701
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.47399321
25	Propanoate metabolism_Homo sapiens_hsa00640	1.45869401
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.44990228
27	Allograft rejection_Homo sapiens_hsa05330	1.42462416
28	RNA transport_Homo sapiens_hsa03013	1.42366939
29	Base excision repair_Homo sapiens_hsa03410	1.40725336
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39254526
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.38535712
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.37841998
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.34803983
34	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.34538316
35	Peroxisome_Homo sapiens_hsa04146	1.30927052
36	Alzheimers disease_Homo sapiens_hsa05010	1.30670090
37	Huntingtons disease_Homo sapiens_hsa05016	1.27081978
38	Collecting duct acid secretion_Homo sapiens_hsa04966	1.25989624
39	Butanoate metabolism_Homo sapiens_hsa00650	1.21637195
40	Type I diabetes mellitus_Homo sapiens_hsa04940	1.21302019
41	Fatty acid elongation_Homo sapiens_hsa00062	1.21028401
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.18606715
43	Graft-versus-host disease_Homo sapiens_hsa05332	1.18064805
44	Purine metabolism_Homo sapiens_hsa00230	1.14060434
45	Linoleic acid metabolism_Homo sapiens_hsa00591	1.13909376
46	Sulfur metabolism_Homo sapiens_hsa00920	1.13675562
47	Ribosome_Homo sapiens_hsa03010	1.13638286
48	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12076300
49	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.11596719
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.08185415
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.06943661
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06901749
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.05520368
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.04579998
55	Selenocompound metabolism_Homo sapiens_hsa00450	1.03696556
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.99085862
57	Caffeine metabolism_Homo sapiens_hsa00232	0.99080643
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.93820603
59	Antigen processing and presentation_Homo sapiens_hsa04612	0.92484478
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.92325164
61	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.92132474
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90461376
63	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.87563843
64	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.86611435
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.85329633
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.84399357
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.81767338
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79937446
69	Rheumatoid arthritis_Homo sapiens_hsa05323	0.79865527
70	Metabolic pathways_Homo sapiens_hsa01100	0.73483875
71	Glutathione metabolism_Homo sapiens_hsa00480	0.73365797
72	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.71655389
73	Ether lipid metabolism_Homo sapiens_hsa00565	0.68499834
74	Nicotine addiction_Homo sapiens_hsa05033	0.67389875
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65965348
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64464402
77	Olfactory transduction_Homo sapiens_hsa04740	0.62706722
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.60714312
79	Taste transduction_Homo sapiens_hsa04742	0.59227707
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.58613887
81	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.56971384
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56430631
83	Morphine addiction_Homo sapiens_hsa05032	0.52965295
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51756743
85	Retinol metabolism_Homo sapiens_hsa00830	0.47718166
86	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.46082245
87	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.44871023
88	Carbon metabolism_Homo sapiens_hsa01200	0.44400336
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.44354344
90	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43031743
91	Fatty acid degradation_Homo sapiens_hsa00071	0.42846891
92	Steroid biosynthesis_Homo sapiens_hsa00100	0.42279230
93	GABAergic synapse_Homo sapiens_hsa04727	0.42081482
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.41833215
95	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.41631525
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.41494778
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39334422
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.36469489
99	Sulfur relay system_Homo sapiens_hsa04122	0.36351431
100	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.34004252

HNRNPCP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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