ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.65486302
2	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.65486302
3	sulfur amino acid catabolic process (GO:0000098)	5.50481933
4	folic acid-containing compound biosynthetic process (GO:0009396)	5.50161872
5	mitochondrial RNA metabolic process (GO:0000959)	5.37370989
6	rRNA methylation (GO:0031167)	5.35413838
7	homocysteine metabolic process (GO:0050667)	4.88474214
8	rRNA modification (GO:0000154)	4.74894612
9	adenosine metabolic process (GO:0046085)	4.58367006
10	regulation of plasminogen activation (GO:0010755)	4.52316017
11	behavioral response to nicotine (GO:0035095)	4.33157500
12	protein-cofactor linkage (GO:0018065)	4.31146918
13	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.19015096
14	tRNA modification (GO:0006400)	4.05506647
15	DNA strand renaturation (GO:0000733)	4.03977267
16	microtubule nucleation (GO:0007020)	4.01976231
17	transcription from mitochondrial promoter (GO:0006390)	3.93371180
18	acrosome assembly (GO:0001675)	3.86343678
19	meiotic chromosome segregation (GO:0045132)	3.84529220
20	platelet dense granule organization (GO:0060155)	3.81945896
21	preassembly of GPI anchor in ER membrane (GO:0016254)	3.74272085
22	amino acid salvage (GO:0043102)	3.72321136
23	L-methionine salvage (GO:0071267)	3.72321136
24	L-methionine biosynthetic process (GO:0071265)	3.72321136
25	piRNA metabolic process (GO:0034587)	3.69377053
26	cysteine metabolic process (GO:0006534)	3.64833913
27	pteridine-containing compound biosynthetic process (GO:0042559)	3.62593838
28	DNA ligation (GO:0006266)	3.61903985
29	organic cation transport (GO:0015695)	3.60409978
30	folic acid-containing compound metabolic process (GO:0006760)	3.52772223
31	cellular response to ATP (GO:0071318)	3.51217915
32	pseudouridine synthesis (GO:0001522)	3.50825893
33	tetrahydrofolate metabolic process (GO:0046653)	3.47000779
34	purine nucleotide salvage (GO:0032261)	3.38959691
35	sulfur amino acid biosynthetic process (GO:0000097)	3.37012387
36	respiratory chain complex IV assembly (GO:0008535)	3.36213781
37	ribosome biogenesis (GO:0042254)	3.34217062
38	kinetochore organization (GO:0051383)	3.32177659
39	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.31211743
40	L-serine metabolic process (GO:0006563)	3.30782410
41	cellular ketone body metabolic process (GO:0046950)	3.28947609
42	kinetochore assembly (GO:0051382)	3.28569211
43	CENP-A containing nucleosome assembly (GO:0034080)	3.25081598
44	nucleoside transmembrane transport (GO:1901642)	3.23560916
45	branched-chain amino acid catabolic process (GO:0009083)	3.18935740
46	tRNA processing (GO:0008033)	3.16469123
47	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.14414413
48	NADH dehydrogenase complex assembly (GO:0010257)	3.14414413
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.14414413
50	tryptophan metabolic process (GO:0006568)	3.11218299
51	aspartate family amino acid catabolic process (GO:0009068)	3.08108948
52	DNA catabolic process, exonucleolytic (GO:0000738)	3.07758621
53	chromatin remodeling at centromere (GO:0031055)	3.02447744
54	regulation of skeletal muscle contraction (GO:0014819)	3.01895206
55	regulation of synapse structural plasticity (GO:0051823)	3.01610588
56	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.01513781
57	primary amino compound metabolic process (GO:1901160)	2.96113941
58	DNA methylation involved in gamete generation (GO:0043046)	2.95754434
59	galactose metabolic process (GO:0006012)	2.95567098
60	methionine metabolic process (GO:0006555)	2.93754409
61	replication fork processing (GO:0031297)	2.93649352
62	RNA modification (GO:0009451)	2.92309738
63	sulfur amino acid metabolic process (GO:0000096)	2.92072678
64	GPI anchor biosynthetic process (GO:0006506)	2.91527787
65	tryptophan catabolic process (GO:0006569)	2.91015178
66	indole-containing compound catabolic process (GO:0042436)	2.91015178
67	indolalkylamine catabolic process (GO:0046218)	2.91015178
68	phosphatidylglycerol biosynthetic process (GO:0006655)	2.89156066
69	postsynaptic membrane organization (GO:0001941)	2.87971793
70	pteridine-containing compound metabolic process (GO:0042558)	2.84470848
71	protein import into peroxisome matrix (GO:0016558)	2.84168063
72	tRNA metabolic process (GO:0006399)	2.81559596
73	methionine biosynthetic process (GO:0009086)	2.80824034
74	cilium or flagellum-dependent cell motility (GO:0001539)	2.79891279
75	estrogen biosynthetic process (GO:0006703)	2.79238375
76	natural killer cell differentiation (GO:0001779)	2.77827996
77	valine metabolic process (GO:0006573)	2.77470584
78	ketone body metabolic process (GO:1902224)	2.77408632
79	protein complex biogenesis (GO:0070271)	2.76449957
80	inner ear receptor cell development (GO:0060119)	2.73943891
81	regulation of sequestering of triglyceride (GO:0010889)	2.72599432
82	folic acid metabolic process (GO:0046655)	2.71768954
83	DNA double-strand break processing (GO:0000729)	2.71473518
84	GPI anchor metabolic process (GO:0006505)	2.70733970
85	nucleotide transmembrane transport (GO:1901679)	2.69263992
86	aspartate family amino acid metabolic process (GO:0009066)	2.68606484
87	peptidyl-histidine modification (GO:0018202)	2.65695815
88	polyamine metabolic process (GO:0006595)	2.65574527
89	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.64988424
90	white fat cell differentiation (GO:0050872)	2.64975017
91	positive regulation of heat generation (GO:0031652)	2.64765884
92	serine family amino acid catabolic process (GO:0009071)	2.63871892
93	negative regulation of cell aging (GO:0090344)	2.62870653
94	water-soluble vitamin biosynthetic process (GO:0042364)	2.61809315
95	histone exchange (GO:0043486)	2.61198801
96	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.59960118
97	branched-chain amino acid metabolic process (GO:0009081)	2.56351466
98	positive regulation of mitochondrial fission (GO:0090141)	2.55213475
99	mitochondrial respiratory chain complex assembly (GO:0033108)	2.55184244
100	aspartate family amino acid biosynthetic process (GO:0009067)	2.54591234

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	7.94835073
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.08510823
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.66958903
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.66647276
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.65601103
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.64720977
7	E2F7_22180533_ChIP-Seq_HELA_Human	3.25787410
8	VDR_22108803_ChIP-Seq_LS180_Human	3.10432819
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.81946863
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.74465378
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.68456349
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.46392164
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.40447582
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.38440254
15	XRN2_22483619_ChIP-Seq_HELA_Human	2.27163474
16	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.25186933
17	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.24309614
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.18852213
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.15821398
20	GABP_19822575_ChIP-Seq_HepG2_Human	2.05105102
21	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.04240946
22	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.95665869
23	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.92801556
24	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.91977007
25	ZNF274_21170338_ChIP-Seq_K562_Hela	1.72438779
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.70294959
27	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.67978663
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63714472
29	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.62961359
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.55837066
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.49920864
32	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.49347133
33	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.47668958
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.47260627
35	CIITA_25753668_ChIP-Seq_RAJI_Human	1.42710926
36	KDM5A_27292631_Chip-Seq_BREAST_Human	1.42639142
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.42459792
38	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.39885361
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.39411246
40	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.36561122
41	P68_20966046_ChIP-Seq_HELA_Human	1.35711573
42	NCOR_22424771_ChIP-Seq_293T_Human	1.30545713
43	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.28701204
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26103843
45	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.26072504
46	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.25965954
47	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.25204311
48	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.22772933
49	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.22424354
50	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.20095520
51	E2F1_20622854_ChIP-Seq_HELA_Human	1.18971655
52	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.17959860
53	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.17339557
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15909320
55	ERA_21632823_ChIP-Seq_H3396_Human	1.14958483
56	TTF2_22483619_ChIP-Seq_HELA_Human	1.14472331
57	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14293859
58	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.13592149
59	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.13576369
60	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.12653790
61	MYC_19829295_ChIP-Seq_ESCs_Human	1.12624479
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.11844984
63	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11129922
64	EWS_26573619_Chip-Seq_HEK293_Human	1.10483163
65	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.10061525
66	PHF8_20622854_ChIP-Seq_HELA_Human	1.08135436
67	BCL6_27268052_Chip-Seq_Bcells_Human	1.07999575
68	FUS_26573619_Chip-Seq_HEK293_Human	1.06750813
69	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06279361
70	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.05105010
71	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.04791194
72	MYC_18940864_ChIP-ChIP_HL60_Human	1.04556270
73	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03842110
74	OCT4_20526341_ChIP-Seq_ESCs_Human	1.02931001
75	BCOR_27268052_Chip-Seq_Bcells_Human	1.02475960
76	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.97976923
77	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.97848863
78	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.94148778
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92991937
80	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.92732769
81	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.91568827
82	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.90892339
83	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.90361863
84	P53_21459846_ChIP-Seq_SAOS-2_Human	0.89453595
85	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.89306864
86	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.87419509
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.86805181
88	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.86766248
89	MAF_26560356_Chip-Seq_TH2_Human	0.86004856
90	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.85467489
91	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.85223594
92	P300_27268052_Chip-Seq_Bcells_Human	0.84621012
93	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.83934479
94	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.83311755
95	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.83024611
96	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.82222203
97	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.82085270
98	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.81063710
99	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.79750613
100	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.79178984

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	4.16497368
2	MP0000013_abnormal_adipose_tissue	3.94165645
3	MP0002736_abnormal_nociception_after	3.48902003
4	MP0005423_abnormal_somatic_nervous	3.32839207
5	MP0005171_absent_coat_pigmentation	3.31841657
6	MP0001661_extended_life_span	3.31269575
7	MP0005646_abnormal_pituitary_gland	3.03146561
8	MP0001968_abnormal_touch/_nociception	2.90170462
9	MP0005670_abnormal_white_adipose	2.71894109
10	MP0003011_delayed_dark_adaptation	2.60248801
11	MP0004147_increased_porphyrin_level	2.42383116
12	MP0005174_abnormal_tail_pigmentation	2.34798533
13	MP0004043_abnormal_pH_regulation	2.30666875
14	MP0002837_dystrophic_cardiac_calcinosis	2.28148397
15	MP0003646_muscle_fatigue	2.22299709
16	MP0002638_abnormal_pupillary_reflex	2.22018014
17	MP0005360_urolithiasis	2.21788999
18	MP0008058_abnormal_DNA_repair	2.16456259
19	MP0003786_premature_aging	2.16366305
20	MP0005253_abnormal_eye_physiology	2.07145749
21	MP0003183_abnormal_peptide_metabolism	2.03985902
22	MP0005551_abnormal_eye_electrophysiolog	1.97896623
23	MP0010094_abnormal_chromosome_stability	1.92310641
24	MP0008995_early_reproductive_senescence	1.92220997
25	MP0002735_abnormal_chemical_nociception	1.90106580
26	MP0009697_abnormal_copulation	1.89921213
27	MP0002822_catalepsy	1.87566490
28	MP0001756_abnormal_urination	1.78122167
29	MP0008057_abnormal_DNA_replication	1.72707701
30	MP0004130_abnormal_muscle_cell	1.69711111
31	MP0006072_abnormal_retinal_apoptosis	1.60525302
32	MP0005332_abnormal_amino_acid	1.54714719
33	MP0008775_abnormal_heart_ventricle	1.54401436
34	MP0003111_abnormal_nucleus_morphology	1.51807648
35	MP0003880_abnormal_central_pattern	1.49489776
36	MP0008875_abnormal_xenobiotic_pharmacok	1.44067241
37	MP0003693_abnormal_embryo_hatching	1.42915601
38	MP0004145_abnormal_muscle_electrophysio	1.39572287
39	MP0001502_abnormal_circadian_rhythm	1.37025418
40	MP0001853_heart_inflammation	1.34411184
41	MP0000751_myopathy	1.32682085
42	MP0003136_yellow_coat_color	1.32038662
43	MP0004215_abnormal_myocardial_fiber	1.31031161
44	MP0003077_abnormal_cell_cycle	1.30153830
45	MP0001764_abnormal_homeostasis	1.28267084
46	MP0008872_abnormal_physiological_respon	1.28191202
47	MP0002160_abnormal_reproductive_system	1.20288743
48	MP0003186_abnormal_redox_activity	1.14414649
49	MP0005330_cardiomyopathy	1.13936432
50	MP0005367_renal/urinary_system_phenotyp	1.06562365
51	MP0000516_abnormal_urinary_system	1.06562365
52	MP0000538_abnormal_urinary_bladder	1.05679409
53	MP0003195_calcinosis	1.04974944
54	MP0001270_distended_abdomen	1.01756557
55	MP0005365_abnormal_bile_salt	1.01355939
56	MP0006036_abnormal_mitochondrial_physio	1.01016992
57	MP0005085_abnormal_gallbladder_physiolo	1.00706936
58	MP0002095_abnormal_skin_pigmentation	1.00222272
59	MP0003252_abnormal_bile_duct	0.99924013
60	MP0002210_abnormal_sex_determination	0.97481208
61	MP0000747_muscle_weakness	0.94752568
62	MP0002938_white_spotting	0.94351339
63	MP0006276_abnormal_autonomic_nervous	0.92695363
64	MP0001984_abnormal_olfaction	0.91901569
65	MP0000003_abnormal_adipose_tissue	0.91679046
66	MP0010386_abnormal_urinary_bladder	0.91233135
67	MP0003806_abnormal_nucleotide_metabolis	0.87778548
68	MP0001929_abnormal_gametogenesis	0.86466033
69	MP0003698_abnormal_male_reproductive	0.85606348
70	MP0004885_abnormal_endolymph	0.85418982
71	MP0004019_abnormal_vitamin_homeostasis	0.84691225
72	MP0001145_abnormal_male_reproductive	0.84476554
73	MP0001486_abnormal_startle_reflex	0.84376196
74	MP0005075_abnormal_melanosome_morpholog	0.83502889
75	MP0005410_abnormal_fertilization	0.82251799
76	MP0002138_abnormal_hepatobiliary_system	0.78828889
77	MP0008007_abnormal_cellular_replicative	0.78772417
78	MP0004142_abnormal_muscle_tone	0.77145821
79	MP0002396_abnormal_hematopoietic_system	0.76915601
80	MP0005584_abnormal_enzyme/coenzyme_acti	0.74193580
81	MP0000653_abnormal_sex_gland	0.74131547
82	MP0004084_abnormal_cardiac_muscle	0.72699839
83	MP0001919_abnormal_reproductive_system	0.70074314
84	MP0005389_reproductive_system_phenotype	0.67600043
85	MP0000427_abnormal_hair_cycle	0.66752594
86	MP0002876_abnormal_thyroid_physiology	0.66624272
87	MP0004133_heterotaxia	0.66383078
88	MP0006035_abnormal_mitochondrial_morpho	0.65958444
89	MP0002751_abnormal_autonomic_nervous	0.65297648
90	MP0002269_muscular_atrophy	0.64433214
91	MP0009643_abnormal_urine_homeostasis	0.63926195
92	MP0005084_abnormal_gallbladder_morpholo	0.63891051
93	MP0006292_abnormal_olfactory_placode	0.60487843
94	MP0005167_abnormal_blood-brain_barrier	0.59955915
95	MP0005645_abnormal_hypothalamus_physiol	0.56093960
96	MP0005220_abnormal_exocrine_pancreas	0.55405522
97	MP0000631_abnormal_neuroendocrine_gland	0.55321035
98	MP0005083_abnormal_biliary_tract	0.55237676
99	MP0001324_abnormal_eye_pigmentation	0.54878641
100	MP0002928_abnormal_bile_duct	0.53630021

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	5.60867011
2	Abnormality of alanine metabolism (HP:0010916)	5.60867011
3	Hyperalaninemia (HP:0003348)	5.60867011
4	Attenuation of retinal blood vessels (HP:0007843)	4.82848004
5	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.21621316
6	Constricted visual fields (HP:0001133)	3.62460945
7	Abnormality of homocysteine metabolism (HP:0010919)	3.48890792
8	Homocystinuria (HP:0002156)	3.48890792
9	Congenital stationary night blindness (HP:0007642)	3.47110260
10	Testicular atrophy (HP:0000029)	3.43420663
11	Chorioretinal atrophy (HP:0000533)	3.14763784
12	Facial diplegia (HP:0001349)	3.14752803
13	Dyschromatopsia (HP:0007641)	3.11413220
14	Chronic hepatic failure (HP:0100626)	3.10507633
15	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.06420505
16	Congenital sensorineural hearing impairment (HP:0008527)	2.96654342
17	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.95698220
18	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.83914741
19	Duplicated collecting system (HP:0000081)	2.80691248
20	Poor speech (HP:0002465)	2.79512884
21	Abnormality of serum amino acid levels (HP:0003112)	2.77486988
22	Pendular nystagmus (HP:0012043)	2.76707448
23	Birth length less than 3rd percentile (HP:0003561)	2.63294005
24	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.56225413
25	Chromsome breakage (HP:0040012)	2.56209637
26	Abnormality of the renal collecting system (HP:0004742)	2.52941356
27	Brushfield spots (HP:0001088)	2.52858752
28	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.52183538
29	Poikiloderma (HP:0001029)	2.51776345
30	Epiphyseal stippling (HP:0010655)	2.51201549
31	Methylmalonic acidemia (HP:0002912)	2.45069170
32	Squamous cell carcinoma (HP:0002860)	2.43829618
33	Prolonged partial thromboplastin time (HP:0003645)	2.41539287
34	Methylmalonic aciduria (HP:0012120)	2.39669641
35	Abolished electroretinogram (ERG) (HP:0000550)	2.39627719
36	Facial hemangioma (HP:0000329)	2.38946925
37	Type 2 muscle fiber atrophy (HP:0003554)	2.38224129
38	Hypoalphalipoproteinemia (HP:0003233)	2.37214954
39	Pigmentary retinal degeneration (HP:0001146)	2.34207093
40	Anorexia (HP:0002039)	2.33139807
41	Choroideremia (HP:0001139)	2.32047888
42	Panhypogammaglobulinemia (HP:0003139)	2.31325055
43	Increased serum lactate (HP:0002151)	2.30559100
44	Elevated erythrocyte sedimentation rate (HP:0003565)	2.29471263
45	Myopathic facies (HP:0002058)	2.28322412
46	Abnormal epiphyseal ossification (HP:0010656)	2.27436042
47	Amniotic constriction ring (HP:0009775)	2.22710495
48	Abnormality of placental membranes (HP:0011409)	2.22710495
49	Rib fusion (HP:0000902)	2.16039181
50	Increased hepatocellular lipid droplets (HP:0006565)	2.13777533
51	Abnormality of midbrain morphology (HP:0002418)	2.08487977
52	Molar tooth sign on MRI (HP:0002419)	2.08487977
53	Lactic acidosis (HP:0003128)	2.08050921
54	Dicarboxylic aciduria (HP:0003215)	2.05351591
55	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.05351591
56	Ketoacidosis (HP:0001993)	2.04952870
57	Ketosis (HP:0001946)	2.04863324
58	Absent thumb (HP:0009777)	2.04178789
59	Decreased subcutaneous fat (HP:0001002)	2.03034017
60	Tubulointerstitial nephritis (HP:0001970)	2.01370464
61	White forelock (HP:0002211)	2.00954867
62	Patchy hypopigmentation of hair (HP:0011365)	2.00769353
63	Patellar aplasia (HP:0006443)	1.98584246
64	Increased intramyocellular lipid droplets (HP:0012240)	1.98289538
65	Abnormality of the intrinsic pathway (HP:0010989)	1.98192179
66	Cutaneous melanoma (HP:0012056)	1.95754902
67	Hyperglycinemia (HP:0002154)	1.94237719
68	Absent radius (HP:0003974)	1.94206274
69	Action tremor (HP:0002345)	1.92225576
70	Generalized aminoaciduria (HP:0002909)	1.91748208
71	Muscle fiber atrophy (HP:0100295)	1.91503352
72	Rectovaginal fistula (HP:0000143)	1.91166145
73	Rectal fistula (HP:0100590)	1.91166145
74	Brittle hair (HP:0002299)	1.90604656
75	Aplasia/Hypoplasia of the patella (HP:0006498)	1.89217936
76	Type II diabetes mellitus (HP:0005978)	1.86587893
77	3-Methylglutaconic aciduria (HP:0003535)	1.86081266
78	Aplasia of the musculature (HP:0100854)	1.84875260
79	Optic disc pallor (HP:0000543)	1.84848436
80	Long clavicles (HP:0000890)	1.84247575
81	Aplasia involving forearm bones (HP:0009822)	1.84016204
82	Absent forearm bone (HP:0003953)	1.84016204
83	Exercise intolerance (HP:0003546)	1.83059796
84	Conjugated hyperbilirubinemia (HP:0002908)	1.82229884
85	Progressive microcephaly (HP:0000253)	1.80895674
86	Increased CSF lactate (HP:0002490)	1.80390021
87	Mitochondrial inheritance (HP:0001427)	1.78958268
88	Malignant hyperthermia (HP:0002047)	1.78358846
89	Bile duct proliferation (HP:0001408)	1.77909220
90	Abnormal biliary tract physiology (HP:0012439)	1.77909220
91	Abnormality of the carotid arteries (HP:0005344)	1.77806738
92	Lipid accumulation in hepatocytes (HP:0006561)	1.77143395
93	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.77107770
94	Fetal akinesia sequence (HP:0001989)	1.76514570
95	Joint hemorrhage (HP:0005261)	1.76250964
96	Neonatal respiratory distress (HP:0002643)	1.75165033
97	Severe combined immunodeficiency (HP:0004430)	1.74270939
98	Myotonia (HP:0002486)	1.72478330
99	Hepatocellular necrosis (HP:0001404)	1.71626440
100	Abnormality of DNA repair (HP:0003254)	1.68412827

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CCNB1	3.94186015
2	ZAK	3.41072958
3	PINK1	3.03963098
4	TESK2	2.71613818
5	FRK	2.48272338
6	WNK4	2.38638333
7	TLK1	2.31004461
8	MAPK15	2.21760973
9	TRIM28	2.15290410
10	MAP4K2	2.13029965
11	ADRBK2	2.06499812
12	NEK2	2.02658446
13	ACVR1B	1.88305724
14	TTK	1.83708756
15	PHKG2	1.79350452
16	PHKG1	1.79350452
17	TXK	1.78014277
18	BUB1	1.74653502
19	EIF2AK3	1.69310793
20	OBSCN	1.69231041
21	SRPK1	1.69070893
22	SIK2	1.63751019
23	TSSK6	1.53848497
24	VRK2	1.51251081
25	NEK1	1.47235049
26	PDK2	1.42278411
27	PBK	1.38107529
28	INSRR	1.32655923
29	VRK1	1.29928361
30	BMPR1B	1.28454343
31	MAP3K4	1.22965449
32	ATR	1.22950189
33	ADRBK1	1.22348214
34	TNIK	1.21174602
35	FGR	1.20979940
36	MUSK	1.20073135
37	PLK3	1.18770905
38	CDC7	1.17487082
39	NUAK1	1.15831204
40	DYRK2	1.15115456
41	MAP3K3	1.09553847
42	MKNK2	1.09091044
43	MST4	1.01024009
44	STK16	1.00556889
45	AURKA	1.00154751
46	LIMK1	0.97182949
47	MAP2K7	0.96563955
48	MAP2K3	0.96411986
49	TAOK3	0.94067965
50	PLK1	0.93992856
51	RPS6KB2	0.92096038
52	GRK1	0.89389383
53	PLK4	0.85283624
54	TEC	0.84746443
55	NTRK2	0.83659039
56	PAK3	0.83490293
57	MAPKAPK3	0.80489160
58	TIE1	0.77120300
59	EIF2AK2	0.76969788
60	RPS6KB1	0.72121492
61	CDK9	0.71018465
62	BCKDK	0.69784873
63	SGK494	0.69420497
64	SGK223	0.69420497
65	CDK7	0.67953655
66	CHEK2	0.67380969
67	TGFBR1	0.67288441
68	JAK3	0.66055371
69	MAPK11	0.61993181
70	STK3	0.60674794
71	PASK	0.59937024
72	RPS6KA5	0.58426925
73	LMTK2	0.57405766
74	AURKB	0.55877311
75	MKNK1	0.55636469
76	CSNK1A1	0.55149154
77	WNK1	0.54824028
78	WNK3	0.54711787
79	PRKD3	0.50822118
80	DAPK1	0.50775632
81	CAMKK2	0.45679677
82	CSNK2A1	0.44992135
83	MAP4K1	0.44371743
84	BRSK1	0.42932038
85	PRKAA1	0.42659561
86	PRKCG	0.42620375
87	ATM	0.42335868
88	AKT2	0.41408239
89	PIK3CA	0.41213409
90	NEK6	0.39109053
91	RPS6KA1	0.36761348
92	CHEK1	0.36435386
93	MAPK13	0.36171489
94	STK10	0.35777176
95	PRKCQ	0.34616777
96	CAMK1	0.33725803
97	IKBKB	0.33334740
98	CDK1	0.33074415
99	PRKCA	0.32626746
100	PRKACA	0.32596965

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	3.11316491
2	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	3.10417174
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.88155045
4	Sulfur relay system_Homo sapiens_hsa04122	2.68928645
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.55046541
6	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.48078542
7	Sulfur metabolism_Homo sapiens_hsa00920	2.43558507
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.31016455
9	Basal transcription factors_Homo sapiens_hsa03022	2.21873906
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.15843696
11	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.13013878
12	Proteasome_Homo sapiens_hsa03050	2.11061409
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.04497778
14	Base excision repair_Homo sapiens_hsa03410	2.01026497
15	Non-homologous end-joining_Homo sapiens_hsa03450	1.99633303
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.94203274
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.92424217
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.87370791
19	Peroxisome_Homo sapiens_hsa04146	1.84587967
20	Fatty acid elongation_Homo sapiens_hsa00062	1.70564415
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.63379603
22	Homologous recombination_Homo sapiens_hsa03440	1.60941521
23	Butanoate metabolism_Homo sapiens_hsa00650	1.58813683
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.57171478
25	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.56381235
26	Arginine biosynthesis_Homo sapiens_hsa00220	1.52949396
27	Propanoate metabolism_Homo sapiens_hsa00640	1.43855301
28	DNA replication_Homo sapiens_hsa03030	1.38332609
29	Fatty acid metabolism_Homo sapiens_hsa01212	1.36635679
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.35190741
31	RNA polymerase_Homo sapiens_hsa03020	1.34996963
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.21738782
33	Protein export_Homo sapiens_hsa03060	1.20793624
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.18481410
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.17910714
36	Nucleotide excision repair_Homo sapiens_hsa03420	1.17187645
37	RNA degradation_Homo sapiens_hsa03018	1.14901694
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.14856925
39	Nicotine addiction_Homo sapiens_hsa05033	1.11628859
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.09328884
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.08051513
42	RNA transport_Homo sapiens_hsa03013	1.03087495
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.01858190
44	Mismatch repair_Homo sapiens_hsa03430	1.01542141
45	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.01420442
46	Fatty acid degradation_Homo sapiens_hsa00071	1.01256565
47	Arginine and proline metabolism_Homo sapiens_hsa00330	1.00984789
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.99123892
49	Taste transduction_Homo sapiens_hsa04742	0.97406877
50	Retinol metabolism_Homo sapiens_hsa00830	0.96032295
51	Regulation of autophagy_Homo sapiens_hsa04140	0.93336953
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92703172
53	Morphine addiction_Homo sapiens_hsa05032	0.91942115
54	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.91508902
55	Purine metabolism_Homo sapiens_hsa00230	0.89077109
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.87974487
57	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.86016390
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84044075
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81909450
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81385695
61	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.80604165
62	Circadian rhythm_Homo sapiens_hsa04710	0.80213465
63	ABC transporters_Homo sapiens_hsa02010	0.79687030
64	Carbon metabolism_Homo sapiens_hsa01200	0.79144201
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.77581841
66	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.76269915
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76247933
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76234984
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.75868916
70	Glutathione metabolism_Homo sapiens_hsa00480	0.75529561
71	Metabolic pathways_Homo sapiens_hsa01100	0.73084047
72	Steroid biosynthesis_Homo sapiens_hsa00100	0.72630319
73	GABAergic synapse_Homo sapiens_hsa04727	0.71130048
74	Oxidative phosphorylation_Homo sapiens_hsa00190	0.68488137
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67785829
76	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.66363175
77	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.64891485
78	Spliceosome_Homo sapiens_hsa03040	0.62972845
79	Primary immunodeficiency_Homo sapiens_hsa05340	0.62379681
80	Phototransduction_Homo sapiens_hsa04744	0.60008547
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59563489
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.53557188
83	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.53271873
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50128398
85	mRNA surveillance pathway_Homo sapiens_hsa03015	0.45971110
86	Lysine degradation_Homo sapiens_hsa00310	0.45576785
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44622424
88	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.44402936
89	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.43686838
90	Linoleic acid metabolism_Homo sapiens_hsa00591	0.42691950
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42160971
92	Parkinsons disease_Homo sapiens_hsa05012	0.40512921
93	Caffeine metabolism_Homo sapiens_hsa00232	0.38138044
94	Alcoholism_Homo sapiens_hsa05034	0.37045978
95	PPAR signaling pathway_Homo sapiens_hsa03320	0.36114425
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.34464957
97	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.33500534
98	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.33440023
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.33139459
100	Cell cycle_Homo sapiens_hsa04110	0.32090086

HNRNPCP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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