ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of memory T cell differentiation (GO:0043380)	6.48414084
2	ADP metabolic process (GO:0046031)	6.09123751
3	AMP metabolic process (GO:0046033)	5.88587772
4	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	5.57081194
5	DNA deamination (GO:0045006)	5.53429121
6	positive regulation of defense response to virus by host (GO:0002230)	4.95790631
7	positive regulation of cell fate commitment (GO:0010455)	4.81918505
8	rRNA modification (GO:0000154)	4.46940625
9	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.46845059
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.42775512
11	regulation of activation of Janus kinase activity (GO:0010533)	4.20721010
12	rRNA methylation (GO:0031167)	4.17320956
13	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	4.11702822
14	regulation of interleukin-12 biosynthetic process (GO:0045075)	3.94894594
15	hair cycle (GO:0042633)	3.93663447
16	molting cycle (GO:0042303)	3.93663447
17	piRNA metabolic process (GO:0034587)	3.92148521
18	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.71666552
19	isotype switching (GO:0045190)	3.71666552
20	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.71666552
21	negative regulation of neurological system process (GO:0031645)	3.69946037
22	cellular response to nicotine (GO:0071316)	3.69778007
23	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.62004290
24	positive regulation of T-helper 1 type immune response (GO:0002827)	3.56994158
25	purine ribonucleoside diphosphate metabolic process (GO:0009179)	3.53861889
26	purine nucleoside diphosphate metabolic process (GO:0009135)	3.53861889
27	negative regulation of mast cell activation (GO:0033004)	3.48915936
28	positive regulation of osteoclast differentiation (GO:0045672)	3.38654225
29	metallo-sulfur cluster assembly (GO:0031163)	3.37458870
30	iron-sulfur cluster assembly (GO:0016226)	3.37458870
31	DNA methylation involved in gamete generation (GO:0043046)	3.36948589
32	water-soluble vitamin biosynthetic process (GO:0042364)	3.35976863
33	protein K6-linked ubiquitination (GO:0085020)	3.35825612
34	protein complex biogenesis (GO:0070271)	3.34372619
35	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.34309534
36	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.34105864
37	purine deoxyribonucleotide metabolic process (GO:0009151)	3.31929546
38	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.26618683
39	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	3.23766803
40	cytidine deamination (GO:0009972)	3.22799701
41	cytidine metabolic process (GO:0046087)	3.22799701
42	cytidine catabolic process (GO:0006216)	3.22799701
43	cullin deneddylation (GO:0010388)	3.22277922
44	synapsis (GO:0007129)	3.20001100
45	positive regulation of interleukin-17 production (GO:0032740)	3.18395989
46	nucleoside diphosphate phosphorylation (GO:0006165)	3.17657781
47	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.16287759
48	protein deneddylation (GO:0000338)	3.14394358
49	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.11818678
50	positive regulation of prostaglandin secretion (GO:0032308)	3.06840358
51	mitochondrial respiratory chain complex assembly (GO:0033108)	3.05419637
52	UTP metabolic process (GO:0046051)	3.04673046
53	regulation of B cell receptor signaling pathway (GO:0050855)	3.01995502
54	negative regulation of interleukin-10 production (GO:0032693)	2.98607471
55	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.94012064
56	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.94012064
57	mitochondrial RNA metabolic process (GO:0000959)	2.93769091
58	base-excision repair, AP site formation (GO:0006285)	2.92979358
59	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.92396794
60	ATP synthesis coupled proton transport (GO:0015986)	2.92396794
61	tRNA processing (GO:0008033)	2.92175442
62	pseudouridine synthesis (GO:0001522)	2.91040682
63	regulation of defense response to virus by host (GO:0050691)	2.90651129
64	transcription from mitochondrial promoter (GO:0006390)	2.89775550
65	GTP biosynthetic process (GO:0006183)	2.88688033
66	respiratory chain complex IV assembly (GO:0008535)	2.88230079
67	behavioral response to nicotine (GO:0035095)	2.87710911
68	somatic diversification of immunoglobulins (GO:0016445)	2.87171266
69	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.85753358
70	mannosylation (GO:0097502)	2.84435916
71	regulation of T cell mediated cytotoxicity (GO:0001914)	2.82367784
72	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.80091351
73	proteasome assembly (GO:0043248)	2.79956745
74	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.77926293
75	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.77926293
76	cytochrome complex assembly (GO:0017004)	2.76420255
77	rRNA catabolic process (GO:0016075)	2.75375398
78	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.74689964
79	pantothenate metabolic process (GO:0015939)	2.72830899
80	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.69626681
81	NADH dehydrogenase complex assembly (GO:0010257)	2.69626681
82	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.69626681
83	preassembly of GPI anchor in ER membrane (GO:0016254)	2.68802371
84	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.67101069
85	tRNA metabolic process (GO:0006399)	2.66009681
86	maturation of 5.8S rRNA (GO:0000460)	2.64564674
87	estrogen biosynthetic process (GO:0006703)	2.64354520
88	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.64234857
89	peptidyl-histidine modification (GO:0018202)	2.63818381
90	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.62676680
91	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.61644861
92	branched-chain amino acid catabolic process (GO:0009083)	2.59543776
93	tRNA modification (GO:0006400)	2.59123083
94	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.57813543
95	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.56720885
96	protein polyglutamylation (GO:0018095)	2.56549661
97	protein-cofactor linkage (GO:0018065)	2.56514969
98	ribonucleoside diphosphate metabolic process (GO:0009185)	2.55978043
99	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.54527558
100	vitamin transmembrane transport (GO:0035461)	2.52439195

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.62108113
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.01184188
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.87800912
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.68172584
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.14137678
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.10222961
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.96318233
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.93391980
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.82802281
10	VDR_22108803_ChIP-Seq_LS180_Human	2.80986243
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.57754121
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.55854535
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.53306061
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.32748836
15	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.29916222
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.24536019
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.24072121
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.02399392
19	EZH2_22144423_ChIP-Seq_EOC_Human	1.86339220
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.86105930
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81372710
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.80089517
23	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.77157983
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73498241
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.70653869
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.69610437
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.68804329
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.66524883
29	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.65038471
30	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.54165522
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.53779793
32	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.52612641
33	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.50384971
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.49716546
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.48338860
36	EWS_26573619_Chip-Seq_HEK293_Human	1.47625376
37	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.47116908
38	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.47068961
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43568448
40	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43175101
41	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.40797125
42	GATA3_26560356_Chip-Seq_TH2_Human	1.40774543
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34690467
44	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.29525602
45	P300_19829295_ChIP-Seq_ESCs_Human	1.28468259
46	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.27659087
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26837788
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26837788
49	FUS_26573619_Chip-Seq_HEK293_Human	1.25229044
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.24303907
51	NCOR_22424771_ChIP-Seq_293T_Human	1.23808603
52	HOXB7_26014856_ChIP-Seq_BT474_Human	1.23389355
53	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.22710012
54	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.22597284
55	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.20729668
56	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20550564
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.15224798
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15204899
59	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.15111880
60	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.14645891
61	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.14607475
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12430113
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12430113
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12191212
65	OCT4_20526341_ChIP-Seq_ESCs_Human	1.11438023
66	ER_23166858_ChIP-Seq_MCF-7_Human	1.08268239
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07491945
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07128121
69	E2F7_22180533_ChIP-Seq_HELA_Human	1.06858336
70	TTF2_22483619_ChIP-Seq_HELA_Human	1.05002259
71	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.04809030
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04418225
73	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02671212
74	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.01219860
75	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00561095
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99718255
77	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.99446585
78	AR_20517297_ChIP-Seq_VCAP_Human	0.96756370
79	KDM5A_27292631_Chip-Seq_BREAST_Human	0.95724502
80	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.94404496
81	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.94280414
82	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.94225203
83	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.94199225
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93246075
85	MYC_19829295_ChIP-Seq_ESCs_Human	0.93156873
86	DCP1A_22483619_ChIP-Seq_HELA_Human	0.92996468
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92976207
88	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.92833360
89	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.92353565
90	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.91816749
91	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.90765611
92	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.90610359
93	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.90293790
94	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.89821406
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.89338735
96	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.88964437
97	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.88822075
98	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.88744164
99	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.87938236
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.87938236

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.19666355
2	MP0003195_calcinosis	3.99868173
3	MP0008877_abnormal_DNA_methylation	3.08097699
4	MP0002876_abnormal_thyroid_physiology	2.56478537
5	MP0005075_abnormal_melanosome_morpholog	2.56094287
6	MP0001501_abnormal_sleep_pattern	2.55914312
7	MP0005671_abnormal_response_to	2.24019438
8	MP0002102_abnormal_ear_morphology	2.16798086
9	MP0006292_abnormal_olfactory_placode	2.10515300
10	MP0002837_dystrophic_cardiac_calcinosis	2.05781069
11	MP0003646_muscle_fatigue	2.04512959
12	MP0008058_abnormal_DNA_repair	2.04000641
13	MP0003718_maternal_effect	2.02918349
14	MP0003693_abnormal_embryo_hatching	2.00364533
15	MP0000685_abnormal_immune_system	1.96328581
16	MP0003011_delayed_dark_adaptation	1.95697018
17	MP0005167_abnormal_blood-brain_barrier	1.94798456
18	MP0005646_abnormal_pituitary_gland	1.87107015
19	MP0008875_abnormal_xenobiotic_pharmacok	1.80113818
20	MP0001984_abnormal_olfaction	1.79029946
21	MP0001188_hyperpigmentation	1.75729424
22	MP0004885_abnormal_endolymph	1.74833215
23	MP0005084_abnormal_gallbladder_morpholo	1.69481641
24	MP0000372_irregular_coat_pigmentation	1.69076889
25	MP0003806_abnormal_nucleotide_metabolis	1.64268015
26	MP0001764_abnormal_homeostasis	1.62452491
27	MP0008775_abnormal_heart_ventricle	1.58753552
28	MP0002653_abnormal_ependyma_morphology	1.57337692
29	MP0008872_abnormal_physiological_respon	1.56786160
30	MP0009785_altered_susceptibility_to	1.52221498
31	MP0005410_abnormal_fertilization	1.51102100
32	MP0001986_abnormal_taste_sensitivity	1.48959169
33	MP0002163_abnormal_gland_morphology	1.47254640
34	MP0004145_abnormal_muscle_electrophysio	1.47208322
35	MP0005551_abnormal_eye_electrophysiolog	1.46430489
36	MP0005377_hearing/vestibular/ear_phenot	1.46184955
37	MP0003878_abnormal_ear_physiology	1.46184955
38	MP0002160_abnormal_reproductive_system	1.40614024
39	MP0005379_endocrine/exocrine_gland_phen	1.38553915
40	MP0004142_abnormal_muscle_tone	1.35406218
41	MP0002138_abnormal_hepatobiliary_system	1.35039157
42	MP0001800_abnormal_humoral_immune	1.32742299
43	MP0004782_abnormal_surfactant_physiolog	1.31406157
44	MP0005389_reproductive_system_phenotype	1.31285356
45	MP0001968_abnormal_touch/_nociception	1.27315145
46	MP0004043_abnormal_pH_regulation	1.24522273
47	MP0001790_abnormal_immune_system	1.23391019
48	MP0005387_immune_system_phenotype	1.23391019
49	MP0010094_abnormal_chromosome_stability	1.22538798
50	MP0002272_abnormal_nervous_system	1.21317973
51	MP0002735_abnormal_chemical_nociception	1.19035238
52	MP0003950_abnormal_plasma_membrane	1.18517525
53	MP0002148_abnormal_hypersensitivity_rea	1.18104139
54	MP0002736_abnormal_nociception_after	1.17755263
55	MP0009745_abnormal_behavioral_response	1.17143494
56	MP0003786_premature_aging	1.16718090
57	MP0005645_abnormal_hypothalamus_physiol	1.15208926
58	MP0003638_abnormal_response/metabolism_	1.13714107
59	MP0006072_abnormal_retinal_apoptosis	1.12380147
60	MP0003866_abnormal_defecation	1.11188193
61	MP0009764_decreased_sensitivity_to	1.07797135
62	MP0003122_maternal_imprinting	1.06144707
63	MP0001905_abnormal_dopamine_level	1.05953933
64	MP0003121_genomic_imprinting	1.05935207
65	MP0001765_abnormal_ion_homeostasis	1.05731890
66	MP0005000_abnormal_immune_tolerance	1.05185838
67	MP0002733_abnormal_thermal_nociception	1.03041015
68	MP0002723_abnormal_immune_serum	1.01719769
69	MP0005365_abnormal_bile_salt	1.01389820
70	MP0003787_abnormal_imprinting	0.94724838
71	MP0006276_abnormal_autonomic_nervous	0.92745032
72	MP0003724_increased_susceptibility_to	0.92457084
73	MP0003303_peritoneal_inflammation	0.91085088
74	MP0006036_abnormal_mitochondrial_physio	0.88948483
75	MP0005253_abnormal_eye_physiology	0.88614574
76	MP0002452_abnormal_antigen_presenting	0.86665402
77	MP0008995_early_reproductive_senescence	0.85544291
78	MP0003436_decreased_susceptibility_to	0.85317515
79	MP0002572_abnormal_emotion/affect_behav	0.81847443
80	MP0001919_abnormal_reproductive_system	0.80465495
81	MP0003698_abnormal_male_reproductive	0.80274473
82	MP0001663_abnormal_digestive_system	0.75544589
83	MP0005395_other_phenotype	0.75087942
84	MP0002938_white_spotting	0.74929422
85	MP0004215_abnormal_myocardial_fiber	0.74464065
86	MP0001929_abnormal_gametogenesis	0.73929483
87	MP0009697_abnormal_copulation	0.73687878
88	MP0005360_urolithiasis	0.73312435
89	MP0001835_abnormal_antigen_presentation	0.72479563
90	MP0002405_respiratory_system_inflammati	0.71916612
91	MP0009046_muscle_twitch	0.71581791
92	MP0001819_abnormal_immune_cell	0.70580762
93	MP0000689_abnormal_spleen_morphology	0.68791759
94	MP0000703_abnormal_thymus_morphology	0.68282723
95	MP0002557_abnormal_social/conspecific_i	0.67323042
96	MP0005332_abnormal_amino_acid	0.67270198
97	MP0000230_abnormal_systemic_arterial	0.66244755
98	MP0002420_abnormal_adaptive_immunity	0.66214531
99	MP0001873_stomach_inflammation	0.66173125
100	MP0005636_abnormal_mineral_homeostasis	0.64118703

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Optic neuritis (HP:0100653)	4.54415168
2	Retrobulbar optic neuritis (HP:0100654)	4.54415168
3	Orchitis (HP:0100796)	3.64466821
4	Renal cortical cysts (HP:0000803)	3.32992485
5	IgG deficiency (HP:0004315)	3.23780111
6	Type II lissencephaly (HP:0007260)	3.20571818
7	Lipid accumulation in hepatocytes (HP:0006561)	3.12391454
8	Methylmalonic acidemia (HP:0002912)	3.11631240
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.05514302
10	Acute necrotizing encephalopathy (HP:0006965)	3.05311325
11	Keratoconjunctivitis (HP:0001096)	3.02750939
12	Prostate neoplasm (HP:0100787)	2.98003348
13	Mitochondrial inheritance (HP:0001427)	2.97608265
14	Progressive inability to walk (HP:0002505)	2.97041528
15	Myositis (HP:0100614)	2.95863811
16	Hepatic necrosis (HP:0002605)	2.91742094
17	Keratoconjunctivitis sicca (HP:0001097)	2.89435984
18	Medial flaring of the eyebrow (HP:0010747)	2.86826911
19	Increased CSF lactate (HP:0002490)	2.82465410
20	Acute encephalopathy (HP:0006846)	2.74340520
21	Colon cancer (HP:0003003)	2.72783225
22	Methylmalonic aciduria (HP:0012120)	2.70323707
23	Pancreatic cysts (HP:0001737)	2.68823507
24	Abnormality of methionine metabolism (HP:0010901)	2.68584840
25	Abolished electroretinogram (ERG) (HP:0000550)	2.68467783
26	Hepatocellular necrosis (HP:0001404)	2.66149234
27	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.64465887
28	Inability to walk (HP:0002540)	2.63197186
29	Abnormality of the renal cortex (HP:0011035)	2.59519488
30	Generalized aminoaciduria (HP:0002909)	2.58247257
31	Bile duct proliferation (HP:0001408)	2.55623259
32	Abnormal biliary tract physiology (HP:0012439)	2.55623259
33	Nephronophthisis (HP:0000090)	2.55120240
34	Recurrent cutaneous fungal infections (HP:0011370)	2.54748633
35	Chronic mucocutaneous candidiasis (HP:0002728)	2.54748633
36	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.53169638
37	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.53169638
38	Adactyly (HP:0009776)	2.51513067
39	Chronic hepatic failure (HP:0100626)	2.43875553
40	Gait imbalance (HP:0002141)	2.38570507
41	Progressive macrocephaly (HP:0004481)	2.38540192
42	Congenital primary aphakia (HP:0007707)	2.37797659
43	Retinal dysplasia (HP:0007973)	2.34449790
44	Increased serum lactate (HP:0002151)	2.32308340
45	Hypophosphatemic rickets (HP:0004912)	2.31012856
46	Cerebral edema (HP:0002181)	2.30738164
47	Abnormality of the pons (HP:0007361)	2.29195020
48	Increased hepatocellular lipid droplets (HP:0006565)	2.25311580
49	Abnormality of midbrain morphology (HP:0002418)	2.24652989
50	Molar tooth sign on MRI (HP:0002419)	2.24652989
51	Dicarboxylic aciduria (HP:0003215)	2.22860041
52	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.22860041
53	Stomach cancer (HP:0012126)	2.22105141
54	Gaze-evoked nystagmus (HP:0000640)	2.19564557
55	Abnormality of the labia minora (HP:0012880)	2.18729298
56	Encephalitis (HP:0002383)	2.17722746
57	Increased muscle lipid content (HP:0009058)	2.17175279
58	Cheilitis (HP:0100825)	2.16468816
59	Stomatitis (HP:0010280)	2.15020324
60	True hermaphroditism (HP:0010459)	2.14771107
61	Nephrogenic diabetes insipidus (HP:0009806)	2.14656040
62	Congenital stationary night blindness (HP:0007642)	2.14365580
63	Pancreatic fibrosis (HP:0100732)	2.13639136
64	Abnormality of the prostate (HP:0008775)	2.13508392
65	Brittle hair (HP:0002299)	2.10072474
66	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.09607524
67	Facial diplegia (HP:0001349)	2.09522486
68	Lactic acidosis (HP:0003128)	2.09505831
69	Renal Fanconi syndrome (HP:0001994)	2.07353309
70	Hypoplasia of the pons (HP:0012110)	2.00385299
71	Optic disc pallor (HP:0000543)	1.99807396
72	Type 2 muscle fiber atrophy (HP:0003554)	1.98248607
73	Abnormality of vitamin B metabolism (HP:0004340)	1.96733436
74	Increased intramyocellular lipid droplets (HP:0012240)	1.96027139
75	Parakeratosis (HP:0001036)	1.95627020
76	Keratitis (HP:0000491)	1.91806154
77	Hyperglycinuria (HP:0003108)	1.88669288
78	Opisthotonus (HP:0002179)	1.88233817
79	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.86966183
80	Lethargy (HP:0001254)	1.86876518
81	Increased density of long bones (HP:0006392)	1.86633671
82	Hemoptysis (HP:0002105)	1.84407022
83	Type I transferrin isoform profile (HP:0003642)	1.84317104
84	Abnormality of urine glucose concentration (HP:0011016)	1.82919796
85	Glycosuria (HP:0003076)	1.82919796
86	Poor coordination (HP:0002370)	1.77442451
87	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.76728442
88	Hyperglycinemia (HP:0002154)	1.74665510
89	Abnormality of glycine metabolism (HP:0010895)	1.73950284
90	Abnormality of serine family amino acid metabolism (HP:0010894)	1.73950284
91	Pendular nystagmus (HP:0012043)	1.73556309
92	Abnormal protein glycosylation (HP:0012346)	1.72539603
93	Abnormal glycosylation (HP:0012345)	1.72539603
94	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.72539603
95	Abnormal protein N-linked glycosylation (HP:0012347)	1.72539603
96	Abnormal spermatogenesis (HP:0008669)	1.71407007
97	Abnormality of the renal medulla (HP:0100957)	1.70944703
98	Nausea (HP:0002018)	1.70939963
99	Rib fusion (HP:0000902)	1.70128488
100	Premature loss of primary teeth (HP:0006323)	1.69479694

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.57689529
2	ZAK	3.37491059
3	NUAK1	2.81038906
4	EIF2AK3	2.74501262
5	MST4	2.51564825
6	FRK	2.46167287
7	TAF1	2.29943862
8	TXK	2.29896082
9	TSSK6	2.26977367
10	MAPKAPK5	2.25951173
11	BUB1	2.13636646
12	MAP4K2	2.05867934
13	ADRBK2	2.03049703
14	MKNK1	2.03027734
15	NME1	2.01722808
16	VRK1	1.90358692
17	CDC7	1.88193996
18	NEK1	1.83789968
19	GRK1	1.79448815
20	TESK2	1.79423589
21	TAOK3	1.76541605
22	WNK4	1.75531429
23	TNK2	1.72058883
24	BCKDK	1.59231678
25	PLK3	1.58449966
26	LIMK1	1.57250262
27	TRIM28	1.49237963
28	IKBKB	1.46204141
29	PHKG1	1.44378752
30	PHKG2	1.44378752
31	SIK3	1.42235747
32	MUSK	1.39515282
33	DAPK2	1.32986154
34	TIE1	1.31255187
35	WNK3	1.26632415
36	PLK4	1.26604534
37	EPHA3	1.26204134
38	BMPR1B	1.25511055
39	ATR	1.18687188
40	TEC	1.13315382
41	KIT	1.03714266
42	SMG1	1.02073889
43	CHUK	0.93061449
44	TLK1	0.92504820
45	MAPK13	0.91809240
46	MATK	0.89112264
47	STK39	0.87138760
48	RPS6KA5	0.85864987
49	OXSR1	0.84573894
50	WNK1	0.81336283
51	DYRK2	0.80631864
52	SRPK1	0.79445327
53	MKNK2	0.78911370
54	PDK2	0.77662959
55	CSNK1A1L	0.77041973
56	ITK	0.74796996
57	PLK2	0.73341427
58	EIF2AK2	0.70231035
59	PRKCQ	0.70062876
60	CSNK1G3	0.68683576
61	INSRR	0.66806193
62	ERBB3	0.66738270
63	BCR	0.63014574
64	TTK	0.61920015
65	PLK1	0.60620267
66	IKBKE	0.59730253
67	PRKCE	0.59462107
68	FER	0.57561721
69	SYK	0.57233294
70	CSNK1A1	0.55993621
71	PRKCH	0.51164685
72	CSNK1G1	0.51091967
73	FES	0.51030276
74	PRKCI	0.50639503
75	PIK3CA	0.48866808
76	TNIK	0.47702718
77	CAMK2A	0.47548171
78	DAPK1	0.46272626
79	ATM	0.45867390
80	PRKCG	0.45725162
81	MAP2K2	0.44737950
82	AURKB	0.44504745
83	PINK1	0.43949921
84	CSNK2A1	0.43937742
85	PAK6	0.43005945
86	IGF1R	0.41633254
87	PIM2	0.40164147
88	EIF2AK1	0.38145051
89	LYN	0.37917822
90	CHEK2	0.37072549
91	ALK	0.36664352
92	GRK5	0.36619473
93	TRPM7	0.35761703
94	CSNK1G2	0.35360796
95	PTK2B	0.35264117
96	STK38L	0.34970897
97	PRKACA	0.34378493
98	CHEK1	0.32953002
99	LMTK2	0.32781770
100	CSNK2A2	0.32491190

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.53879076
2	Protein export_Homo sapiens_hsa03060	2.86256117
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.76428898
4	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.56639564
5	Propanoate metabolism_Homo sapiens_hsa00640	2.38614293
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.31164626
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.18695380
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.12005989
9	Mismatch repair_Homo sapiens_hsa03430	2.11489123
10	Homologous recombination_Homo sapiens_hsa03440	2.10158398
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.05263375
12	Parkinsons disease_Homo sapiens_hsa05012	2.01101251
13	DNA replication_Homo sapiens_hsa03030	2.00215372
14	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.99793087
15	One carbon pool by folate_Homo sapiens_hsa00670	1.97948307
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.93633543
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.89781733
18	RNA degradation_Homo sapiens_hsa03018	1.85841581
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.84877522
20	Phototransduction_Homo sapiens_hsa04744	1.79707878
21	Sulfur metabolism_Homo sapiens_hsa00920	1.70883367
22	RNA polymerase_Homo sapiens_hsa03020	1.68786597
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.67050503
24	Purine metabolism_Homo sapiens_hsa00230	1.62190624
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.59640694
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.56289807
27	Basal transcription factors_Homo sapiens_hsa03022	1.55081917
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.41615932
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.40743020
30	Base excision repair_Homo sapiens_hsa03410	1.36187408
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.33656311
32	RNA transport_Homo sapiens_hsa03013	1.32972334
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.30473199
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.26610418
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.23704937
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.17349745
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10930736
38	Spliceosome_Homo sapiens_hsa03040	1.08927163
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.07156754
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.02771010
41	Alzheimers disease_Homo sapiens_hsa05010	1.02435249
42	Huntingtons disease_Homo sapiens_hsa05016	1.02294976
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00169567
44	Caffeine metabolism_Homo sapiens_hsa00232	0.98832751
45	Butanoate metabolism_Homo sapiens_hsa00650	0.96737055
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.95712946
47	Peroxisome_Homo sapiens_hsa04146	0.93709670
48	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.93079897
49	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.91765176
50	Nicotine addiction_Homo sapiens_hsa05033	0.91559236
51	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.91540371
52	Retinol metabolism_Homo sapiens_hsa00830	0.90970329
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.87399957
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.86579877
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86316312
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.85391334
57	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.84082973
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.83962150
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81737075
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.81327329
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78363576
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.77773620
63	Metabolic pathways_Homo sapiens_hsa01100	0.75661119
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.74881967
65	Olfactory transduction_Homo sapiens_hsa04740	0.72401512
66	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.70767066
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.70381749
68	Type I diabetes mellitus_Homo sapiens_hsa04940	0.67987402
69	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.67206452
70	Cardiac muscle contraction_Homo sapiens_hsa04260	0.66946648
71	mRNA surveillance pathway_Homo sapiens_hsa03015	0.65424345
72	Taste transduction_Homo sapiens_hsa04742	0.60133006
73	Asthma_Homo sapiens_hsa05310	0.57409338
74	Folate biosynthesis_Homo sapiens_hsa00790	0.55567886
75	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.54282192
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52549688
77	Fatty acid elongation_Homo sapiens_hsa00062	0.50996225
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.50934587
79	Graft-versus-host disease_Homo sapiens_hsa05332	0.50667867
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.47087976
81	Antigen processing and presentation_Homo sapiens_hsa04612	0.46378439
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45544594
83	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.45543845
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.45185803
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.44485134
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43306412
87	Arginine biosynthesis_Homo sapiens_hsa00220	0.41821953
88	Fatty acid degradation_Homo sapiens_hsa00071	0.39932764
89	Measles_Homo sapiens_hsa05162	0.37448629
90	Serotonergic synapse_Homo sapiens_hsa04726	0.36902837
91	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.36411161
92	Glutathione metabolism_Homo sapiens_hsa00480	0.36315177
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.34683003
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34611323
95	Allograft rejection_Homo sapiens_hsa05330	0.33853061
96	Sulfur relay system_Homo sapiens_hsa04122	0.32788485
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32303716
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.31621718
99	p53 signaling pathway_Homo sapiens_hsa04115	0.31531375
100	ABC transporters_Homo sapiens_hsa02010	0.29473384

HNRNPCP8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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